ISRN Gastroenterology

Volume 2012 (2012), Article ID 919371, 6 pages

doi:10.5402/2012/919371

Clinical Study

Short-Term Effects and Early Complications of Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Varices

Manabu Watanabe, Kazue Shiozawa, Takashi Ikehara, Shigeru Nakano, Michio Kougame, Takafumi Otsuka, Yoshinori Kikuchi, Koji Ishii, Yoshinori Igarashi, and Yasukiyo Sumino

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Toho University Medical Center, Omori Hospital, 6-11-1 Omorinishi, Ota-ku, Tokyo 143-8541, Japan

Received 15 October 2012; Accepted 31 October 2012

Academic Editors: H. Asakura and J.-P. Buts

Copyright © 2012 Manabu Watanabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

The short-term effects of balloon-occluded retrograde transvenous obliteration (BRTO) to treat gastric varices were evaluated by using computed tomography (CT) and gastroscopy (GF). The subjects were 77 patients who underwent BRTO to treat gastric varices. The short-term effects of BRTO were investigated with regard to ascites, pleural effusion, venous thrombus, and esophageal varices by comparing the findings of CT and GF performed within one month before and after BRTO. The mean duration of followup was 960.1 days. Ascites and pleural effusion were exacerbated after BRTO in 26 (33.8%) and 31 (40.3%), respectively. A significant difference in ascites exacerbation was noted in patients with hypoalbuminemia and a high Child-Pugh score, and a significant difference in exacerbation of pleural effusion was noted in patients with hypoalbuminemia. Venous thrombus was noted in 7 patients (9.1%). Esophageal varices were exacerbated in 14 (21.2%) of the 66 patients. The 2-year survival rate was 720 days, and significant differences were noted in the Child-Pugh classification and the concomitance of hepatocellular carcinoma (HCC) on multivariate analysis of prognosis-related factors. Conclusion. The frequencies of exacerbation of ascites, pleural effusion, and esophageal varices after BRTO were high but these may not be related to survival.

1. Introduction

Balloon occluded retrograde transvenous obliteration (BRTO) is widely accepted as an effective treatment for gastric varices [1, 2]. Sclerosing agents, that is, ethanolamine oleate (EO) and 50% glucose, are injected directly into varices via the drainage veins, and at the same time, blood flow in the varices is stopped by retrograde balloon occlusion. This method can achieve a high-BRTO success rate, 90%, and a low-recurrence rate, 10% [1–4]. However, BRTO also markedly influences portal hemodynamics because it occludes major portosystemic shunts, it increases the portal hepatic blood flow and portal blood pressure. In many reports, the liver function has been shown to be improved by an increase in portal hepatic blood flow [5, 6], but BRTO may also exacerbate symptoms of portal hypertensive changes, including ascites, splenomegaly, and the development of portosystemic collaterals, and the influence on respiratory function and complication of venous thrombus are of concern [7–12]. While aggravation of esophageal varices in the late period or long term by BRTO has been investigated [13], the short-term effects and complications after BRTO in patients with portal hypertension have not been investigated sufficiently, to date. In this study, we retrospectively evaluated the short-term effects and early complications of BRTO by performing computed tomography (CT) and gastroscopy (GF) before and after BRTO and extracted the predictors of the cumulative survival rate by multivariate analysis.

2. Methods

2.1. Patients

Among the hepatic cirrhosis and portal hypertensive patients with gastrorenal shunt, 79 underwent BRTO to treat gastric varices between October 2006 and July 2011, and 77 of them were involved in this study, after excluding 2 patients who could not be followed after BRTO (Table 1). This study was approved by the IRB of our hospital. There were 51 male and 26 female patients (age: 14–90 years, mean age: years). Emergency BRTO was performed within 48 hours after temporary hemostasis of gastric variceal hemorrhage with GF in 15 patients, prophylactic BRTO for hemorrhage was performed in 62 patients with gastric varices. The background liver disease was viral hepatic cirrhosis in 39 patients, alcoholic hepatic cirrhosis in 26, nonalcoholic steatohepatitis (NASH) in 4, primary biliary cirrhosis (PBC) in 3, autoimmune hepatitis (AIH) in 2, and idiopathic portal hypertension (IPH) in 3. The mean serum albumin (Alb) and total bilirubin (T-bil) levels, prothrombin time (PT), and platelet count immediately before BRTO were (g/dL), (mg/dL), (%), and (10⁴/μL), respectively. The Child-Pugh score was , and the Child-Pugh class was A in 32 patients, B in 37, and C in 8. Thirty patients had hepatocellular carcinoma (HCC). Regarding esophageal varices, GF was not performed within one week before BRTO in 9 patients and within one month after BRTO in 2 patients. Excluding these patients, 66 patients were included in the evaluation.

Table 1: Characteristics before BRTO.

Age (years)
61.6 ± 12.2

Gender

    Male
51

    Female
26

Timing of treatment

    Emergency cases
15

    Prophylactic cases
62

Etiology

    HBV
3

    HCV
36

    Alcohol
26

    NASH
4

    PBC
3

    AIH
2

    IPH
3

Serum albumin (g/dL)
3.2 ± 0.6

Serum total bilirubin (mg/dL)
1.3 ± 0.7

Prothrombin time (%)
72.7 ± 13.2

Plateles (×10⁴ μL)
9.2 ± 3.7

Child-Pugh

    Score
7.2 ± 1.7

    Classification

        A (5-6)
32

        B (7–9)
37

        C (10–15)
8

Esophageal varices

    Present
44

    Absent
24

    Unknown
9

Hepatocellular carcinoma

    Present
30

    Absent
47

Values expressed as mean ± standard deviation.

2.2. BRTO Procedure

Written informed consent for BRTO was obtained from all patients or responsible family members. BRTO was performed as reported previously [14–17]. Employing the Seldinger method, a sheath was inserted via the right femoral or right internal jugular vein, and a 5-6 Fr catheter with a 10–30 mm occlusion balloon was inserted into the draining vessel branching from the left renal vein using a guide wire. After advancing the balloon into the draining vessel, pressure was applied to the balloon, and retrograde venography was performed under balloon occlusion. When thin collateral circulation, that is, via the inferior phrenic and pericardiac veins, was imaged, these underwent embolization with a metal coil using a microcatheter. Under balloon occlusion, 5% EO (1 : 1 mixture of 10% ethanolamine oleate and iopamidol contrast medium) was slowly injected into the varix intermittently under fluoroscopy. At the same time, haptoglobin was injected into the median cubital vein. The catheter was left in the vessel with the balloon inflated until the following day and then removed after confirming complete occlusion of the varix under fluoroscopy. When occlusion was incomplete, the 5% EO injection was repeated until complete occlusion was achieved. The mean volume of injected 5% EO was  mL. The injection volume of EO was determined based on the volume of contrast medium required to image the varix, and the maximum volume per day was set at 0.4 mL/Kg.

2.3. Images and Analysis

CT was performed within 2 weeks after BRTO using one of 2 multirow detector computed tomography (MDCT) scanners (Toshiba Medical Systems and GE healthcare). The images were obtained in the craniocaudal direction from the superior margin of the heart to the lower pole of the right kidney in 5 mm slices with 2.5–5 mm reconstruction. Ninety milliliters of nonionic contrast medium (Ultravist 300, Schering AG, Berlin, Germany) was injected at 3 mL/sec using an automatic injector. Images of the arterial and equilibrium phases were obtained, 35 and 120 seconds after intravenous injection of the contrast medium, respectively. On plain CT and imaging of the equilibrium phase, the region over the pelvis was imaged. Preprocedual CT was performed within one week before BRTO.

The pre- and postprocedual CT scans were retrospectively compared by two gastroenterologists working in consensus with respect to the short-term effects of BRTO on the following changes; ascites, pleural effusion, and venous thrombus. Regarding the ascites and pleural effusion, new appearance and increases upon comparison of the CT images were judged as exacerbation. As for venous thrombus, those that newly appeared in the portal, splenic, and left renal veins, other than the varices, were regarded as positive. As for esophageal varices, new appearance on GF within one month after BRTO, an increase in form ( factor), and appearance of red color sign (RC) were judged as exacerbation. Preoperative GF was performed within one week before BRTO.

Factors influencing ascites, pleural effusion, and venous thrombus after BRTO were investigated. The cumulative survival rate and factors influencing the cumulative survival rate were also investigated. Among the factors influencing the cumulative survival rate, age 70 years, gender, emergency BRTO, viral hepatic cirrhosis, serum albumin level (g/dL), elevated total bilirubin level (mg/dL), PT of 70% or higher, platelet count of 8.0 ( 10⁴/μL) or higher, Child-Pugh classification, concomitance of HCC, exacerbation of ascites and pleural effusion, and the appearance of venous thrombi were investigated. For blood test findings, those obtained on the day before or the day of BRTO were used. The significance of differences in background factors was analyzed using the paired -, Mann-Whitney, and -tests. For analysis of survival, the Kaplan-Meier method and Log rank test were used, and when a significant difference was observed, multivariate analysis using the Cox proportional hazards model was performed, and the hazard ratio was calculated. values of less than 0.05 were considered to indicate statically significance.

3. Results

Table 2 shows the results of CT and GF after BRTO. Ascites and pleural effusion were exacerbated in 26 (33.8%) and 31 (40.3%) of the 77 patients, respectively. Ascites was present in 11 patients before BRTO, and improved in one. Pleural effusion was exacerbated on the left side in 25 (80.7%) of the 31 patients with exacerbation of pleural effusion. No pleural effusion was present before BRTO in any patient. Venous thrombus was noted in 7 patients (9.1%): portal thrombus in 3, splenic venous thrombus in 2, and left renal venous thrombus in 2. Exacerbation of esophageal varices occurred in 14 (21.2%) of the 66 patients. Among the factors exacerbating ascites, significant differences were noted in patients with hypoalbuminemia (), hyperbilirubinemia (), low PT% (), and high Child-Pugh score () (Table 3). A significant difference in exacerbation of pleural effusion was noted only in the patients with hypoalbuminemia () (Table 4). No significant differences were noted due to venous thrombus for any of the factors (Table 5). Simultaneous exacerbation of ascites and pleural effusion was noted in 17 (22.1%) of the 77 patients, and these factors were associated significantly (). In contrast, no association was noted between exacerbation of ascites and venous thrombus or between exacerbation of pleural effusion and venous thrombus. The 1- and 2-year survival rates were 94.3 and 79.2%, respectively (Figure 1). Regarding the relationship between each factor and the survival rate, significant differences were noted in the Child-Pugh classification and the presence or absence of HCC ( and 0.0005, resp.,) (Table 6). On multivariate analysis, the hazard ratio was 6.27 (95% CI: 2.075–19.009) in the Child-Pugh class B/C group and 3.0136 (95% CI: 1.236–7.349) in the group with HCC complications, showing that these were independent factors (Table 7).

Table 2: Short-term effects and early complications after BRTO.

Present
Absent
%

CT

    Ascites
26
51
33.8

    Pleural effusion
31
46
40.3

        Location L/R/B
25/1/5

80.7/3.2/16.1

    Thrombus
7
70
9.1

        Location PV/SPV/Lt.RV
3/2/2

43.0/28.5/28.5

Endoscopy

    Worsening of esophageal varices
14
52
21.2

          (unknown: 11)

PV: portal vein, SPV: splenic vein, Lt.RV: left renal vein.

Table 3: Comparison of demographic variables between the patients with and without ascites after BRTO.

Ascites
Yes ()
No ()
P value

Age (years)
64.2 ± 10.6
60.2 ± 12.8
0.1778

Gender

0.3666

    Male
19
32

    Female
7
19

Timing of treatment

0.2439

    Emergency cases
7
8

    Prophylactic cases
19
43

Etiology

0.9351

    Viral infection
13
26

    No viral infection
13
25

Serum albumin (g/dL)
2.95 ± 0.47
3.36 ± 0.61
0.0067 *

Serum total bilirubin

(mg/dL)
1.53 ± 0.92
1.12 ± 0.55
0.0342 *

Prothrombin time (%)
66.88 ± 12.43
75.71 ± 12.71
0.0076 *

Platelets (×10⁴ μL)
8.13 ± 2.89
9.68 ± 4.03
0.0915

Child-Pugh score
8.08 ± 1.60
6.76 ± 1.57
0.0023 *

Hepatocellular carcinoma

0.9488

    Present
10
20

    Absent
16
31

CT findings

    Pleural effusion
17
14
0.0013 *

    Thrombus
2
5
0.7611

* .

Table 4: Comparison of demographic variables between the patients with and without pleural effusion after BRTO.

Pleural effusion
Yes ()
No ()
P value

Age (years)
63.9 ± 11.2
60.0 ± 12.6
0.1631

Gender

0.7937

    Male
20
31

    Female
11
15

Timing of treatment

0.5737

    Emergency cases
7
8

    Prophylactic cases
24
38

Etiology

0.8896

    Viral infection
16
23

    No viral infection
15
23

Serum albumin (g/dL)
3.05 ± 0.44
3.34 ± 0.66
0.0412 *

Serum total bilirubin

(mg/dL)
1.40 ± 0.99
1.17 ± 0.44
0.1742

Prothrombin time (%)
71.00 ± 13.09
73.89 ± 13.31
0.3459

Platelets (×10⁴ μL)
8.37 ± 2.76
9.69 ± 4.22
0.1367

Child-Pugh score
7.58 ± 1.48
6.96 ± 1.79
0.1144

Hepatocellular carcinoma

0.9704

    Present
12
18

    Absent
19
28

CT findings

    Ascites
17
9
0.0019 *

    Thrombus
4
3
0.3479

* .

Table 5: Comparison of demographic variables between the patients with and without thrombus development in the major systemic and portal vein after BRTO.

Thrombus
Yes ()
No ()
P value

Age (years)
57.4 ± 12.3
61.9 ± 12.2
0.3480

Gender

0.7937

    Male
5
46

    Female
2
24

Timing of treatment

0.7175

    Emergency cases
1
14

    Prophylactic cases
6
56

Etiology

0.6666

    Viral infection
3
36

    No viral infection
4
34

Serum albumin (g/dL)
2.8 ± 0.49
3.27 ± 0.59
0.0566

Serum total bilirubin

(mg/dL)
1.34 ± 0.59
1.25 ± 0.73
0.7470

Prothrombin time (%)
65.57 ± 13.55
73.44 ± 13.06
0.1370

Platelets (×10⁴ μL)
9.48 ± 2.43
9.12 ± 3.85
0.8062

Child-Pugh score
8.28 ± 1.70
7.10 ± 1.66
0.0873

Hepatocellular carcinoma

0.9704

    Present
3
27

    Absent
4
43

CT findings

    Ascites
2
24
0.7611

    Pleural effusion
4
27
0.3479

Table 6: Univariate analysis of prognostic factors affecting overall survival after BRTO.

Variable
value

Age (≥70 y)
0.2667

Gender (male)
0.2714

Emergency cases
0.1547

Etiology (viral)
0.3892

Alb (≥3.0 g/dL)
0.1371

T-bil (≥1.4 mg/dL)
0.8149

PT (≥70%)
0.9645

Platelets (≥8.0 × 10⁴ μL)
0.6529

Child-Puge classification B/C
0.023

HCC (present)
0.0005

Esophageal varices (present)
0.5296

Ascites (present)
0.095

Pleural effusion (present)
0.064

Thrombus (present)
0.8823

Alb: serum albumin, T-bil: serum total bilirubin, PT: prothrombin time, HCC: hepatocellular carcinoma.

Table 7: Multivariate analysis of prognostic factors affecting overall survival after BRTO.

Variable
RR (95% CI)
value

Child-Puge classification B/C
6.2798 (2.0746–19.0094)
0.028

HCC (present)
3.0136 (1.2358–7.3491)
0.004

HCC: hepatocellular carcinoma.

Figure 1: Cumulative survival rate of all patients after BRTO.

4. Discussion

The incidence of ascites exacerbation after BRTO has been reported to be low (0–10%) [2, 7, 9, 18], but the modality and timing of evaluation among these reports varies: exacerbation of ascites was evaluated between 24 hours and 4 weeks after BRTO, varying between facilities, and evaluation has not been standardized. In our study, ascites were exacerbated and increased in 33.8% (26/77) within a short time (2 weeks) after BRTO. Cho et al. [8] also reported that ascites was noted on CT in 82% within one week after BRTO, suggesting that the frequency of ascites exacerbation is high immediately to 2 weeks after BRTO. In previous reports on portal hemodynamics [5, 6, 19], portal blood pressure rose significantly immediately after BRTO and then decreased slowly to the baseline 4 weeks after BRTO. Hypoalbuminemia and a high Child-Pugh score were extracted as factors involved in the exacerbation of ascites, and were noted in patients with advanced hepatic cirrhosis. Based on these findings, it was assumed that the addition of temporary portal hypertension to poor liver function exacerbated the ascites, but appropriate evaluation may be difficult when the treatment outcome is only evaluated several months after BRTO due to the combined progression of hepatic cirrhosis-associated ascites. On the other hand, ascites improved after BRTO in one patient. An increase in serum albumin is one factor related to improving ascites. It has also been reported that occlusion of shunts by BRTO increased portal blood flow and resulted in mid- to long-term improvement of liver function [5, 20]. However, in general, albumin levels have been reported to decrease one month after BRTO and it is unlikely that improvement of ascites within 2 weeks after BRTO, as was observed in this patient, would have been due to improvement of the serum albumin levels. Indeed, in this patient, the Child-Pugh class was C, showing poor liver function, and the albumin levels at the time-points of BRTO and ascites evaluation by CT were 2.1 (g/dL) and 2.0 (g/dL), respectively. Thus, the mechanism underlying the influence of BRTO on ascites is complex [21], and further elucidation is necessary.

The reported incidence of pleural effusion after BRTO is in the range of 7%–71% of these patients [7, 11, 13, 18]. In our study, pleural effusion was exacerbated after BRTO in 40.3% (31/77), and it was significant in the patients with hypoalbuminemia. Arai et al. [13] observed a significant difference in the EO dose injected as a sclerosing agent in patients in whom pleural effusion appeared early after BRTO, and concluded that the cause was pulmonary infarction or pulmonary edema induced by EO through vascular shunts. Regarding the pleural effusion that appears following esophageal varix treatment, Kayama et al. [22] suggested that it was related to the EO dose used, and Bacon et al. [23] suggested that the cause was EO-induced inflammation of the mediastinal pleura. Unfortunately, we detected no significant relationship between the EO dose and the development of pleural effusion (data not shown, ), but the incidence of pleural effusion after BRTO was high. In addition, the incidence of left pleural effusion alone was high (80.7%) among the patients in whom pleural effusion was noted, which could be important. As reported previously, while one possible cause of the exacerbation of pleural effusion was pulmonary infarction and pulmonary edema, considering that the exacerbation of the pleural effusion was unilateral, it could also be possible that the main cause of the exacerbation of pleural effusion was inflammation of the pleura induced by EO influx into the left inferior phrenic, pericardiac, and innominate veins and many anastomotic branches continuous to the gastrorenal shunts that are distributed around the diaphragm. In addition, exacerbation of ascites and pleural effusion was noted simultaneously in 17 (22.1%) of the 77 patients, and these were associated significantly. Furthermore, the exacerbation of pleural effusion was significant in patients with hypoalbuminemia, suggesting that it could serve as an exacerbation factor of ascites, as well as pleural effusion. EO immediately binds albumin in the blood, resulting in its inactivation [24]. It is necessary to further investigate the influence of EO as a sclerosing agent on the lung and whole body, when free EO enters the systemic circulation in hypoalbuminemia.

Venous thrombus was noted in 9.1% (7/77) of the patients, suggesting that this is a relatively frequent complication. No causal relationship between venous thrombus formation and liver function, ascites, or pleural effusion was noted. The main cause of this venous thrombosis may be intravascular injury due to poor catheter procedure or impairment of vascular endothelium by leakage of EO from the draining or feeding vessel [25]. Cho et al. [11, 12] also reported that venous thrombus was noted after BRTO on CT in 15% (9/60), showing that this is a frequent complication. There have been no other previous reports that have described venous thrombus after BRTO in detail, and only the present study has evaluated the presence or absence of venous thrombus by CT as an early complication, within 2 weeks after BRTO. Since the thrombus later disappeared in 4 patients who could be followed, it is unlikely that venous thrombus that had appeared early after BRTO was involved in the later severe complication and survival, but it should be recognized as a BRTO-associated complication that occurs at a relatively high incidence.

According to preceding reports [3, 9], exacerbation of collateral veins can occur one or more months after BRTO. Miyamoto et al. [6] reported that elevated portal pressure immediately after BRTO returned to baseline within four weeks along with the development of substitutive collateral circulation. In our study, exacerbation of esophageal varices was noted on GF within one month after BRTO in 25.8% (14/66), but no remarkable exacerbation, that is, from F0 to F2/3 or from F1 to F3, was noted. Of the 14 cases of esophageal variceal exacerbation on GF, only one case could be confirmed by CT. Cho et al. investigated the appearance of collateral veins immediately after BRTO using CT and observed no new collateral vein or development of existing collateral vein. Based on these findings, the influence of portal blood pressure elevation immediately after BRTO on esophageal varices may not be significant enough to be detected as wall thickening on CT.

When factors contributing to worsening the prognosis, including ascites, pleural effusion, and venous thrombus observed, immediately after BRTO, were investigated by multivariate analysis using the Cox proportional hazards model, Child-Pugh classes excluding A and complication of HCC were reported as prognostic factors. This result was consistent with those in preceding reports [2, 3].

In conclusion, ascites, pleural effusion, and esophageal varices may become exacerbated within a short time after BRTO. It was suggested that the ascites was exacerbated by hypofunction of the liver and rapid development of portal hypertension after BRTO, and the direct cause of the exacerbation of pleural effusion was EO, which was used as a sclerosing agent. However, the exacerbations of pleural effusion and ascites were associated, and these may have been due to hypoalbuminemia; further supporting that the details of the mechanism are still unclear. However, it was suggested that ascites, pleural effusion, and venous thrombus, which appear early after BRTO, are not prognosis-exacerbating factors.

Conflict of Interests

No potential conflict of interests relevant to this paper was reported.

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