ISRN Organic Chemistry

Volume 2013 (2013), Article ID 185120, 5 pages

http://dx.doi.org/10.1155/2013/185120

Research Article

Solvent-Free Green and Efficient One-Pot Synthesis of Dihydropyrano[3,2-c]chromene Derivatives

Shubha Jain, Deepika Rajguru, Balwant S. Keshwal, and Aman D. Acharya

School of Studies in Chemistry, Vikram University, Ujjain, Madhya Pradesh 456010, India

Received 17 June 2013; Accepted 19 August 2013

Academic Editors: M. D'Auria, R. Pohl, D. Sémeril, and S. B. Wan

Copyright © 2013 Shubha Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

A rapid, clean, and highly efficient method for synthesis of dihydropyrano[3,2-c]chromene derivatives by one-pot, three-component condensation of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin using DABCO as catalyst in solvent-free neat conditions is described. The present method has the advantages of mild reaction conditions, short reaction times, easy isolation of products, and excellent yields.

1. Introduction

Multicomponent reactions (MCRs) are very important in organic synthesis due to the formation of carbon-carbon and carbon-hetero atom bonds in one pot [1–3]. Simple procedures, high bond forming efficiency, time and energy saving, and low expenditures are among the advantages of these reactions [4]. Over the past several years, chemists have been aware of the environmental implications of their chemistry. Nowadays, they are trying to develop new synthetic methods, reaction conditions, and uses of chemicals that reduce the risks to humans and the environment. Organic solvents are high on the list of hazardous chemicals because they are used in large amounts and are usually volatile liquids. Therefore, in recent years, solventless organic reactions have attracted great interest. They have many advantages such as high efficiency and selectivity, operational simplicity, low costs, mild reaction conditions, and reduced pollution [5–7]. Pyrano[3,2-c]chromenes are a class of important heterocycles with a wide range of biological properties [8] such as spasmolytic, diuretic, anticoagulant, anticancer, and antianaphylactic activity [9]. Moreover, they have been used as cognitive enhancers, for the treatment of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, AIDS associated dementia, and Down’s syndrome as well as for the treatment of schizophrenia and myoclonus [10]. In addition, aminochromene derivatives exhibit a wide spectrum of biological activities including antihypertensive and anti-ischemic behavior [11–13].

Several methods have been reported for the synthesis of pyrano[3,2-c]chromene derivatives. 2-Amino-4-aryl-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitriles have previously been prepared from aromatic aldehydes, malononitrile, and 4-hydroxycoumarin in the presence of organic bases like piperidine or pyridine in an organic solvent, that is, ethanol and pyridine [14]. They have also been prepared in the presence of diammonium hydrogen phosphate (DAHP), (S)-proline [15], K₂CO₃ under microwave irradiation [16], TBAB [17], MgO [18], H₆P₂W₁₈O₆₂18H₂O [19], Hexamethylene tetramine [20], TMGT [21], N,N,N′,N′-tetrabromo benzene-1,3-disulfonamide (TBBDA) and poly(N,N′-dibromo-N-ethyl-benzene-1,3-disulfonamide) (PBBS) [22], 3-hydroxypropanaminium acetate (HPAA) [23], 2-hydroxyethylammonium formate [24], [bmim]Br [25], potassium phthalimide-N-oxyl [26], and CuO nanoparticles [27]. However, some of these methods suffer from the serious limitations such as long reaction times, multistep reactions, complex synthetic pathways, and lower product yields. Therefore, the development of milder, faster, and more ecofriendly methods, accompanied with higher yields is needed.

In recent years, 1,4-diazabicyclo[2.2.2]octane (DABCO) has received considerable attention as an inexpensive, ecofriendly, high reactive, easy to handle, and nontoxic base catalyst for various organic transformations, affording the corresponding products in excellent yields with high selectivity [28, 29]. The reactions are environmentally friendly and the catalyst can be recycled in some cases. In continuation of our interest to further enlarge the application of DABCO as a catalyst [30], here we wish to report one-pot synthesis of pyrano[3,2-c]chromene derivatives by the reaction of aromatic aldehydes, malononitrile, and 4-hydroxycoumarin catalyzed by DABCO in solventless conditions.

2. Results and Discussion

When aromatic aldehyde 1, malononitrile 2, and 4-hydroxy coumarin 3 were condensed in the presence of DABCO in solvent-free neat conditions at 100°C; 2-Amino-4-aryl-3-cyano-5-oxo-4H,5H-pyrano[3,2-c]chromene derivatives 4 were obtained in good to high yields (Scheme 1).

Scheme 1

In our initial study, the reaction of benzaldehyde, malononitrile, and 4-hydroxycoumarin was used as a model reaction to optimize the reaction conditions. First the reaction was conducted in various solvents using DABCO as a catalyst under refluxing conditions and also under solvent-free conditions. As can be seen from Table 1, the best results were obtained in neat. The effect of temperature in solventless conditions was studied by carrying out the reaction at 60, 80, 100, and 120°C. The results from Table 1 (entry 6) showed that 100°C would be the best temperature for all reactions.

Table 1: DABCO catalyzed synthesis of 4a in different reaction conditions.

Entry
Solvent
/°C
Time/h
Yielda/%

1
EtOH
Reflux
2
85

2
CH₂Cl₂
Reflux
6
54

3
CH₃CN
Reflux
4
73

4
THF
Reflux
4
62

5
H₂O
Reflux
1.5
87

6
—
100
0.5
94

7
—
60
2
65

8
—
80
1
76

9
—
120
0.5
92

10b
—
100
2
65

11c
—
100
0.5
95

Isolated yield.

b1 mol% of catalyst was used.

c10 mol% of catalyst was used.

Under the optimized reaction conditions, a series of dihydropyrano[3,2-c]chromene derivatives 4(a–j) were synthesized. The results are summarized in Table 2. In all cases, aromatic aldehydes substituted with either electron-donating or electron-withdrawing groups underwent the reaction smoothly and gave the expected products in good to high yields under the same reaction conditions. Moreover, heteroaromatic aldehydes could also be successfully converted to the corresponding heteroaryl substituted pyrano[3,2-c]chromenes in excellent yields.

Table 2: Synthesis of 2-Amino-4-aryl-3-cyano-5-oxo-4H,5H-pyrano[3,2-c]chromenes in solvent-free neat conditions using DABCO (5 mol%) as catalyst.

Entry
Ar
Product
Time/min
Yield/%
m.p./°C Found (reported)

1
C₆H₅
4a
30
94
256-257 (256–258) [15]

2
4-O₂N C₆H₄
4b
30
96
259–261 (258–260) [15]

3
3-O₂N C₆H₄
4c
30
93
261–263 (262–264) [15]

4
4-ClC₆H₄
4d
30
92
264–267 (263–265) [15]

5
4-BrC₆H₄
4e
30
91
247–250 (249–251) [15]

6
4-CH₃OC₆H₄
4f
30
89
241–244 (240–242) [15]

7
4-CH₃C₆H₄
4g
30
87
252–254 (250–252) [15]

8
2,4-Cl₂C₆H₃
4h
30
90
256–258 (257–259) [15]

9

4i
30
97
251–254 (252-253) [16]

10

4j
30
96
226–230 (228) [20]

3. Conclusion

In summary, a new clean and efficient protocol for the synthesis of pyrano[3,2-c]chromene derivatives using DABCO under solvent-free conditions was described. The use of DABCO as a green, nontoxic, nonexplosive, inexpensive, nonvolatile, easy to handle, and thermally stable catalyst with simple experimental and isolation procedure makes it an attractive method for the preparation of these compounds.

4. Experimental

4.1. General

All chemicals were purchased from Merck and Sigma-Aldrich as “synthesis grade” and used without further purification. Melting points were determined in open glass capillaries and are uncorrected. ¹H NMR spectra were obtained at 400 MHz with a Bruker (AVANCE) spectrometer using DMSO-d₆ as solvent and TMS as an internal standard. Elemental analysis was performed using Carlo Erba-1108 analyzer.

4.2. General Procedure for the Synthesis of 2-Amino-4-aryl-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitriles

Aromatic aldehyde 1 (1 mmoL), malononitrile 2 (1.2 mmoL), 4-hydroxycoumarin 3 (1 mmoL), and DABCO (5 moL%) were mixed thoroughly and heated in a water bath at 100°C for appropriate time. After completion of the reaction (monitored by TLC), the mixture was cooled to room temperature. The solid product was washed with hot water dried and recrystallized from ethanol to give the pure product.

All the compounds were characterized by spectroscopic and physical data which were found to be identical to those described in the literature.

4.2.1. 2-Amino-5-oxo-4-phenyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4a)

White Solid, Yield: 94%; m.p.256-257°C (256–258°C) [15]; Anal. Calcd. for C₁₉H₁₂N₂O₃: C, 72.15; H, 3.82; N, 8.86%. Found: C, 72.28; H, 3.61; N, 8.65%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.16 (1H, s, CH), 6.34 (2H, s, amino group), 7.35–7.44 (5H, m, ArH), 7.53–7.58 (2 H, m, ArH), 7.65–7.71 (2H, m, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 53.27, 103.62, 113.38, 115.83, 116.01, 121.32, 123.14, 123.53, 124.85, 125.08, 127.12, 128.37, 141.35, 152.78, 154.84, 158.19, 159.65.

4.2.2. 2-Amino-4-(4-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4b)

Pale Yellow Solid, Yield: 96%; m.p. 259–261°C (258–260°C) [15]; Anal. Calcd. for C₁₉H₁₁N₃O₅: C, 63.16; H, 3.07; N, 11.63%. Found: C, 63.29; H, 3.19; N, 11.95%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.76 (1H, s, CH), 6.43 (2H, s, amino group), 7.20–7.22 (2H, dd, = 3.9 Hz, = 1.0 Hz, ArH), 7.27 (1H, s, ArH), 7.42 (1H, d, J = 3.6 Hz, ArH), 7.63–7.65 (1H, dd, = 4.2 Hz, = 0.9 Hz, ArH), 7.69 (1H, d, J = 3.7 Hz, ArH), 7.76 (2H, d, J = 1.2 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 57.34, 105.83, 112.56, 115.91, 116.73, 119.26, 122.06, 123.12, 125.49, 126.64, 129.03, 138.23, 148.39, 152.84, 153.17, 158.35, 159.46.

4.2.3. 2-Amino-4-(3-nitrophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4c)

White Solid, Yield: 93%; m.p. 261–263°C (262–264°C) [15]; Anal. Calcd. for C₁₉H₁₁N₃O₅: C, 63.16; H, 3.07; N, 11.63%. Found: C, 63.28; H, 3.17; N, 11.96%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.26 (1H, s, CH), 6.32 (2H, s, amino group), 7.15–7.24 (3H, m, ArH), 7.46 (2H, d, J = 7.6 Hz, ArH), 7.90 (1H, d, J = 2.0 Hz, ArH), 8.33 (1H, d, J = 7.6 Hz, ArH), 8.87 (1H, s, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 55.37, 107.58, 113.35, 115.19, 116.24, 119.73, 122.52, 123.65, 125.54, 128.73, 129.46, 135.48, 148.36, 152.11, 153.72, 158.02, 159.78.

4.2.4. 2-Amino-4-(4-chlorophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4d)

White Solid, Yield: 92%; m.p. 264–267°C (263–265°C) [15]; Anal. Calcd. for C₁₉H₁₁ClN₂O₃: C, 65.06; H, 3.16; N, 7.99%. Found: C, 65.35; H, 3.26; N, 7.73%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.72 (1H, s, CH), 6.74 (2H, s, amino group), 7.22 (1H, t, J = 4.6 Hz, ArH), 7.70–7.73 (3H, m, ArH), 7.84 (2H, d, J = 8.6 Hz, ArH), 8.36 (2H, d, J = 8.6 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 54.72, 106.43, 112.78, 115.62, 116.58, 119.32, 121.09, 123.45, 124.64, 125.92, 128.53, 134.32, 138.10, 152.18, 152.97, 158.49, 159.56.

4.2.5. 2-Amino-4-(4-bromophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4e)

White Solid, Yield: 91%; m.p. 247–250°C (249–251°C) [15]; Anal. Calcd. for C₁₉H₁₁BrN₂O₃: C, 57.74; H, 2.81; N, 7.09%. Found: C, 57.53; H, 2.96; N, 7.17%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.36 (1H, s, CH), 6.60 (2H, s, amino group), 7.44 (2H, d, J = 3.5 Hz, ArH), 7.77 (1H, d, J = 1.7 Hz, ArH), 7.82–7.84 (3H, m, ArH), 8.36–8.38 (2H, dd, = 4.9 Hz, = 1.9 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 55.43, 105.57, 112.58, 115.23, 116.62, 119.82, 121.08, 123.42, 124.78, 126.56, 127.58, 136.45, 139.34, 152.49, 152.84, 157.37, 159.89.

4.2.6. 2-Amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4f)

White Solid, Yield: 89%; m.p. 241–244°C (240–242°C) [15]; Anal. Calcd. for C₂₀H₁₄N₂O₄: C, 69.36; H, 4.07; N, 8.09%. Found: C, 68.92; H, 4.20; N, 8.19%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 3.76 (3H, s, OCH₃), 5.13 (1H, s, CH), 6.36 (2H, s, amino group), 6.65-6.66 (2H, q, J = 1.7 Hz, ArH), 7.41 (2H, d, J = 3.3 Hz, ArH), 7.57 (2H, m, ArH), 7.75 (2H, d, J = 1.5 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 52.95, 57.66, 103.90, 112.96, 116.26, 117.39, 119.28, 122.49, 123.72, 124.32, 125.26, 126.51, 132.42, 138.10, 152.01, 152.95, 158.24, 159.53.

4.2.7. 2-Amino-5-oxo-4-p-tolyl-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4g)

White Solid, Yield: 87%; m.p. 252–254°C (250–252°C) [15]; Anal. Calcd. for C₂₀H₁₄N₂O₃: C, 72.72; H, 4.27; N, 8.48%. Found: C, 72.46; H, 4.19; N, 8.58%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 2.10 (3H, s, CH₃), 4.58 (1H, s, CH), 6.73 (2H, s, amino group), 7.22–7.24 (4H, m, ArH), 7.70-7.71 (2H, dd, = 2.7 Hz, = 1.0 Hz, ArH), 7.74–7.76 (2H, dd, = 4.2 Hz, = 1.0 Hz, ArH); ³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 13.95, 30.57, 55.59, 101.64, 111.65, 112.92, 116.24, 118.88, 122.44, 124.20, 132.47, 146.91, 150.86, 151.93, 152.08, 153.90, 158.74, 159.35.

4.2.8. 2-Amino-4-(2,4-dichlorophenyl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4h)

White Solid, Yield: 90%; m.p. 256–258°C (257–259°C) [15]; Anal. Calcd. for C₁₉H₁₀Cl₂N₂O₃: C, 59.24; H, 2.62; N, 7.27%. Found: C, 59.51; H, 2.49; N, 7.48%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.24 (1H, s, CH), 6.31 (2H, s, amino group), 6.66 (1H, d, J = 3.1 Hz, ArH), 6.71 (1H, t, J = 1.4 Hz, ArH), 7.30 (1H, d, J = 3.2 Hz, ArH), 7.59 (2H, m, ArH), 7.85 (1H, s, ArH), 7.95 (1H, d, J = 0.9 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 28.38, 57.99, 104.05, 113.36, 115.97, 116.19, 119.36, 120.50, 122.40, 123.38, 124.23, 125.34, 127.15, 132.26, 135.03, 151.95, 152.77, 158.15, 159.53.

4.2.9. 2-Amino-4-(furan-2-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4i)

Brown Solid, Yield: 97%; m.p. 251–254°C (252-253°C) [16]; Anal. Calcd. for C₁₇H₁₀N₂O₄: C, 66.67; H, 3.29; N, 9.15%. Found: C, 66.95; H, 3.07; N, 9.27%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 3.92 (1H, s, CH), 6.30 (2H, s, amino group), 6.79–6.81 (1H, dd, = 4.9 Hz, = 1.8 Hz, furan ring), 7.08–7.12 (3H, m, furan ring+ArH), 7.38–7.41 (1H, dd, = 3.4 Hz, = 1.6 Hz, ArH), 7.75 (1H, d, J = 2.5 Hz, ArH), 7.86 (1H, d, J = 4.7 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 30.49, 55.87, 101.64, 106.16, 106.98, 111.55, 112.90, 116.17, 118.86, 122.44, 124.11, 150.92, 151.67, 152.05, 153.94, 158.71, 159.50.

4.2.10. 2-Amino-5-oxo-4-(thiophen-2-yl)-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile (4j)

White Solid, Yield: 96%; m.p. 226–230°C (228°C) [20]; Anal. Calcd. for C₁₇H₁₀N₂O₃S: C, 63.34; H, 3.13; N, 8.69; S, 9.95%. Found: C, 63.53; H, 3.24; N, 8.37; S, 9.68%; ¹H-NMR (400 MHz, DMSO-d₆, δ/ppm): 4.94 (1H, s, CH), 6.54 (2H, s, amino group), 6.98 (1H, m, thiophene ring), 7.20–7.22 (2H, dd, = 3.8 Hz, = 1.3 Hz, thiophene ring), 7.65–7.67 (2H, dd, = 4.2 Hz, = 1.0 Hz, ArH), 7.69-7.70 (2H, dd, = 2.6 Hz, = 1.1 Hz, ArH); ¹³C-NMR (400 MHz, DMSO-d₆, δ/ppm): 31.94, 57.84, 103.97, 116.22, 118.94, 122.51, 124.27, 124.58, 124.67, 127.72, 132.52, 138.41, 140.90, 152.95, 153.84, 158.40, 159.49.

Acknowledgment

The authors thank the director of SAIF, Punjab University, Chandigarh, for NMR spectral data.

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