BMRI
BioMed Research International
2314-6141
2314-6133
Hindawi Publishing Corporation
10.1155/2016/8363179
8363179
Editorial
Neurodegeneration: Etiologies and New Therapies 2016
http://orcid.org/0000-0001-9928-4805
Tan
Eng King
1
Srivastava
Amit K.
2
Arnold
W. David
3
Singh
Mahendra P.
4
Zhang
Yiying
5
1
Department of Neurology
Singapore General Hospital
National Neuroscience Institute and Duke NUS Graduate Medical School
Singapore
169857
sgh.com.sg
2
Department of Pediatric Surgery
University of Texas Health Sciences Center at Houston
Houston
TX 77030
USA
uth.edu
3
Department of Neurology
Division of Neuromuscular Disorders and Department of PM&R and Department of Neuroscience
The Ohio State University Wexner Medical Center
Columbus
OH 43210
USA
osu.edu
4
Toxicogenomics and Predictive Toxicology Division
CSIR-Indian Institute of Toxicology Research
Lucknow
Uttar Pradesh 226 001
India
iitrindia.org
5
Department of Anesthesia
Critical Care and Pain Medicine
Massachusetts General Hospital
Harvard Medical School
Charlestown
MA 02129
USA
harvard.edu
2016
3112016
2016
03
10
2016
05
10
2016
3112016
2016
Copyright © 2016 Eng King Tan et al.
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this special issue, we have 9 articles that highlight diverse biochemical, immunological, molecular, and neuroimaging techniques used to decipher the pathophysiological mechanisms underpinning neurodegeneration in various cellular and animal models. The common diseases are covered, including a review on the therapeutic options in Alzheimer’s disease and a discussion on the factors influencing homocysteine levels in Parkinson’s disease. Of particular interest in this issue is an article on the entity of “chemo brain,” a condition that overlaps between oncology and neurology. “Chemo brain” is a common term used to describe thinking and memory problems that can occur after cancer treatment. Here the authors demonstrate PET evidence of the effect of donepezil on cognitive performance in an animal model. We hope this special issue will generate further interest and debate on the pathoetiology of neurodegenerative diseases and provide a platform to generate impetus to further identify and validate new therapeutic options.
Eng King Tan
Amit K. Srivastava
W. David Arnold
Mahendra P. Singh
Yiying Zhang