BioMed Research International
Volume 2017 (2017), Article ID 1408737, 2 pages
https://doi.org/10.1155/2017/1408737

Corrigendum

Corrigendum to “Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction”

Ijaz Ahmad,1,2 Lingli Huang,¹ Haihong Hao,³ Pascal Sanders,⁴ and Zonghui Yuan1,3

¹National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China
²The University of Agriculture Peshawar, Khyber Pakhtunkhwa 25130, Pakistan
³MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China
⁴Laboratory of Fougères, French Agency for Food, Environmental and Occupational Safety, 94701 Maisons-Alfort Cedex, France

Correspondence should be addressed to Ijaz Ahmad; ijaz_pharma@yahoo.com

Received 17 September 2017; Accepted 12 October 2017; Published 6 November 2017

Copyright © 2017 Ijaz Ahmad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In the article titled “Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction” [1], there was an error in Table . Some antibiotic groups were not correctly classified in Table as raised by Benini and Fumagalli in [2]. The correct statement is that ketolides exhibit concentration-dependent killing and have prolonged persistence and the PK/PD indices responsible for efficacy are AUC24/MIC. Clindamycin and vancomycin exhibit time-dependent killing and have moderate to prolonged persistence and PK/PD indices responsible for efficacy are AUC24/MIC. The corrected table is shown as follows (see Table 3).

Table 3: Classification of antibacterial drugs according to pharmacokinetics and pharmacodynamics indices: different groups of antibacterials, their bacterial effect, and PK/PD integration most closely related their clinical effect.

Group
Drugs
PK/PD indices
Activity
Bacterial effect
Duration of PAE
References

1
Aminoglycosides
/MIC or AUC/MIC
Primarily bactericidal
Concentration-dependent
Prolonged
Martinez et al., 2014 []

Fluoroquinolone
AUC/MIC
Bactericidal
Concentration-dependent
Prolonged
Martinez et al., 2014 []

Enrofloxacin e
/MIC/AUC : MIC
Bacteriostatic
bactericidal
Concentration-dependent

Balaje et al., 2013 []

Azithromycin
AUC₂₄/MIC

Tetracycline
AUC₂₄/MIC
Bacteriostatic
Time-dependent
Prolonged
Martinez et al., 2014 []

Colistin
AUC/MIC

Concentration-dependent
Short
Hengzhuang et al., 2012 []

Metronidazole
/MIC/AUC : MIC

Concentration-dependent

Paul et al., 2005 []

2
Ketolides
AUC/MIC
Bacteriostatic or bactericidal
Concentration-dependent
Prolonged
Martinez et al., 2014 []

Penicillins
Carbapenems
Cephalosporins

Bactericidal
Time-dependent
Non or brief against Gram-negative and prolonged against Gram-positive
Martinez et al., 2014 []

Lincosamides (clindamycin)
AUC/MIC
Bacteriostatic
Time-dependent
Brief
Martinez et al., 2014 []

Trimethoprim

Bacteriostatic alone and bactericidal with combination
Time-dependent
Brief
Martinez et al., 2014 []

Glycopeptides (vancomycin)
AUC/MIC
Bactericidal
Time-dependent
Prolonged
Martinez et al., 2014 []

References

I. Ahmad, L. Huang, H. Hao, P. Sanders, and Z. Yuan, “Application of PK/PD modeling in veterinary field: dose optimization and drug resistance prediction,” BioMed Research International, vol. 2016, Article ID 5465678, pp. 1–12, 2016.

A. Benini and G. F. Fumagalli, “Comment on ‘application of PK/PD modeling in veterinary field: Dose optimization and drug resistance prediction’,” BioMed Research International, vol. 2017, pp. 1-2, 2017.