Chronic kidney disease (CKD) is considered a model of accelerated aging. More specifically, CKD leads to reduced physical functioning and increased frailty, increased vascular dysfunction, vascular calcification and arterial stiffness, high levels of systemic inflammation, and oxidative stress, as well as increased cognitive impairment. Increasing evidence suggests that the cognitive impairment associated with CKD may be related to cerebral small vessel disease and overall impairment in white matter integrity. The triad of poor physical function, vascular dysfunction, and cognitive impairment places patients living with CKD at an increased risk for loss of independence, poor health-related quality of life, morbidity, and mortality. The purpose of this review is to discuss the available evidence of cerebrovascular-renal axis and its interconnection with early and accelerated cognitive impairment in patients with CKD and the plausible role of exercise as a therapeutic modality. Understanding the cerebrovascular-renal axis pathophysiological link and its interconnection with physical function is important for clinicians in order to minimize the risk of loss of independence and improve quality of life in patients with CKD.
1. Introduction
Chronic kidney disease (CKD) affects 45% of adults older than 70 years of age in the US [1]. The incidence of CKD will increase significantly over the next decade due to the increasing incidence of diabetes and hypertension in the rapidly aging US population. The economic cost of CKD is staggering with Medicare spending for patients with CKD aged 65 and older exceeding $50 billion in 2013, representing 20% of all Medicare spending in this age group [2]. Contributing to the high cost of CKD is the remarkably high prevalence of cognitive impairment or overt dementia that ranges 20–50% in older patients with moderate CKD [3–8] and may reach as high as 70% in severe CKD/dialysis [9]. Cognitive impairment impacts patients negatively by contributing to functional dependence and behavioral symptoms that result in poor outcomes and decreased medication and medical care compliance. These negative consequences result in a downward spiral of functional decline and an accelerated loss of independence, which leads to premature institutionalization [10–16]. The negative impact of cognitive impairment on quality of life and emotional wellbeing is significant, and it even affects employment rates negatively [17–20]. Moreover, cognitive function for incident dialysis patients has been found to be correlated with frailty and measures of depression [21]. Additionally, it more than doubles mortality risk and increases days spent in the hospital [15, 22], contributing to the tremendous individual, societal, and economical burden of CKD. We will review the vascular milieu as it is associated with cognitive decline in patients with kidney disease and the potential therapeutic role of exercise.
2. Measurement of Cognitive Impairment
Cognitive impairment is commonly referred to as a reduction in global cognition that is new and affects at least 2 areas of cognitive function that can be measured using a standard cognitive function test (e.g., Mini Mental State Exam (MMSE) or the Montreal Cognitive Assessment (MOCA)) [23, 24]. Impairment can be evident in various cognitive domains: executive function (judgement and planning), language, attention, memory, and visual-spatial learning. Mild cognitive impairment (MCI) is commonly defined as a deficit in global cognition that is not consistent with aging and has not progressed to overt dementia. Although there is a lack of a consensus for a standard definition of MCI, it is known to be present with a performance of 1.5–1.99 standard deviations below the standard norm on a given cognitive test. MCI is mostly manifested in short-term memory loss but can also be manifested as impaired language and executive functions [25, 26]. Importantly, progression from MCI to overt dementia is approximately 15% per year in older patients [26]. Dementia on the other hand is used as the umbrella term for moderate/severe progressive cognitive impairment often defined as scoring 2 standard deviations below population norms in at least 2 cognitive domains [27]. Importantly, overt dementia leads to a loss of independent daily function whereas MCI does not appear to significantly affect independent daily function.
3. Cognitive Impairment and Dementia in CKD
It is well established that patients with kidney disease commonly have some degree of cognitive impairment and that kidney dysfunction is associated with a more rapid decline in mental function than in age matched comparisons [28, 29]. As many as 20–50% of patients with moderate CKD have established cognitive impairment or overt dementia [3–8, 30]. It should be noted that the actual population prevalence and incidence of cognitive impairment are likely underreported because published studies are primarily clinic-based and not true population studies. The United States Renal Data System Annual Data Report found a lower prevalence of cognitive impairment in CKD patients (7.6–16.8%) [22]. However, the true population prevalence is likely substantially higher. This is evidenced by Kurella et al. [6] who reported a 23–28% prevalence of cognitive impairment in stages 3-4 CKD patients (n=80) seen in clinical practice and Murray et al. [9] who reported a prevalence of MCI or dementia in 87% of older dialysis patients. Most published studies have reported a prevalence of cognitive impairment of 20–50% in CKD patients and up to 70% in older patients on dialysis [3–9]. Unfortunately, less than 5% of all renal disease patients with cognitive impairment have been screened or received a medical diagnosis [9, 31]. This suggests that cognitive impairment in this group of patients is severely underdetected and not adequately addressed.
The degree of renal dysfunction appears to be correlated with the degree of cognitive impairment. Cognitive impartment has been shown in multiple studies to be associated with deteriorating renal function well before requiring dialysis, although this association is particularly strong in patients requiring dialysis [31]. Increased serum cystatin C and albuminuria are also associated with accelerated cognitive decline [32–34]. Studies have shown a 15-25% increased risk of cognitive impairment for every 10 ml/min per 1.73 m2 reduction in the estimated glomerular filtration rate (eGFR). Further, there is an increased odds ratio of 2.43 (95% CI 1.38 to 4.29) for cognitive impairment in patients with an eGFR of <45 ml/min/per 1.73 m2 even after adjustment for confounders [7, 35]. Thus, patients with CKD appear to have at least a twofold increased risk of cognitive impairment than those without CKD [7, 8, 30]. This risk increases to fourfold with further reductions in eGFR to <30 ml/min per 1.73 m2 independent of potential confounders [8, 35]. These findings translate to patients with CKD having an increased and accelerated risk of cognitive aging equivalent to 3.6–7 years compared to the general population [32, 36]. However, current physical examination and medical history for patients with CKD or end-stage renal disease (ESRD) do not include cognitive function measures.
In terms of the clinical implications of cognitive impairment in CKD, improving support and access to psychology and social professionals, support groups, and patient education are likely to improve outcomes, although this has yet to be determined. Support of patients with CKD should also include counseling with pharmacists and providers regarding the risk of polypharmacy and potential interactions with patient-initiated supplements. The prevalence of cognitive impairment and dementia in the growing CKD population is likely to cause strain on the healthcare system, individuals, and family members. It is imperative that clinicians recognize the risk of cognitive impairment in the CKD population and include screening for cognitive impairment and initiate prompt treatment and coping strategies.
4. Brain Structure in Renal Disease
Magnetic resonance imaging (MRI) techniques have been used to assess brain structure and function in patients with CKD. Older MRI techniques have shown general cerebral atrophy of the hippocampus, cortical atrophy, and prominent lesions of the frontal lobes [37–39]. More recent MRI studies have been able to show deterioration of functional structures including reduced deep white matter volume, white matter hyperintensities representing small vessel disease, white matter lesions, and overt white matter disease [40–44]. Moreover, white matter lesions (degeneration of cells in the white matter) are frequent (up to 70% in dialysis patients) in CKD patients, even before requiring dialysis, suggesting that structural alterations begin early in the CKD disease process [40–44]. White matter lesions likely reflect vascular damage and cerebral ischemic areas. Advanced MRI techniques including diffusion tensor imaging (DTI) have shown subtle alterations in brain structural connectivity of the white matter via mean diffusivity (MD) and fractional anisotropy (FA). The white matter is important for coordinating interactions between different regions of the brain and is essential for normal functioning of the brain [45–49]. Impaired white matter integrity appears to be a primary contributor to cognitive decline in CKD and is strongly affected by the internal vascular milieu [45, 46]. Several studies have reported a correlation between MD and FA values and neuropsychiatric testing for patients with CKD, on hemodialysis, and after transplant [50–52]. The use of advanced MRI measures such as DTI may provide a method to diagnose early risk of cognitive decline before symptom presentation [53]. Moreover, several newer MRI techniques are emerging such as multicomponent relaxometry techniques that may provide a tool to understand the etiology and the impact of risk factor contribution to cognitive decline in patients with renal disease [47, 50–55]. Notably, structural and functional brain changes appear to occur in conjunction with reduced cerebral blood flow, likely related to systemic and cerebral endothelial dysfunction and arterial calcification [45, 56, 57]. Interestingly, Zhang et al. (2016) attempted to evaluate potential changes in white matter integrity in a small nonrandomized single arm study by assessing patients’ brain functional connectivity before and after kidney transplantation [55]. They reported that structural connectivity values were abnormal before transplantation but returned close to normal values one-month after transplantation. Radić et al. (2011) observed improvement in cognitive function following transplantation, which was maintained at 2-year follow-up [58]. The reasons for these findings are not clear and need to be confirmed in appropriately powered randomized, controlled trials. However, these studies are encouraging and suggest that the adverse brain structural changes may be susceptible to reversal although it is clear that much additional research is needed before any conclusions can be made.
5. Etiology of Cognitive Decline in Kidney Disease
The most common type of dementia in the general population is neurodegenerative dementia (as seen in Alzheimer’s disease) often manifested as atrophy of the hippocampus. Patients with renal disease are more likely to have large and small blood vessel disease, which causes white matter disease and reduced white matter integrity related cognitive impairment that often is superimposed on neurodegenerative disease. This vascular disease results in a high rate and susceptibility of cerebrovascular disease including subclinical microvascular cerebral disease and overt stroke [59–62]. Cerebral microbleeds occur in up to 60% of all patients with CKD and appear to be more frequent in patients with black ethnicity [63, 64]. Moreover, CKD patients have a fivefold increased risk of developing clinical and subclinical cerebrovascular disease, and the annual incidence of stroke is approximately 10%, compared to 2.5% in an age and sex matched population without CKD [22, 65]. This rate is even higher in the dialysis population and may reach as high as a tenfold increased incidence of stroke compared to the general population [66, 67]. There is therefore a strong likelihood that patients with CKD are at an increased risk for cognitive impairment due to vascular disease-related causes, manifested as cerebral microinfarcts and white matter disease, and not overt Alzheimer’s disease per se [68]. The cerebral vascular disease appears to act in conjunction with a neurodegenerative disease process mediated in part by uremic toxins, creatinine levels, and even cystatin C levels [62]. It should be noted that the pathophysiology and etiology of cognitive decline in CKD are complex and multifaceted, and far from completely understood.
6. Risk Factors Associated with Cognitive Decline in CKD
Risk factors for cognitive decline in patients with CKD are listed as follows:
Demographic Factors
African American
Hispanic
Female sex
Older age
Low education
Clinical Factors
Hypertension
Diabetes
Dyslipidemias
Polypharmacy
Sleep quality
Depression
Vascular Milieu
Oxidative stress
Inflammation
Hyperhomocysteinemia
Uremia
Albuminuria
Dialysis Procedure Specific Risk Factors for Cognitive Impairment in End-Stage Renal Disease
Volume and electrolyte fluctuation
Cerebral edema
Cerebral hypoperfusion
Hypotension during dialysis
Excessive cytokine release
Microembolism
Delirium
The traditional risk factors for cerebrovascular disease include African American and Hispanic ethnicity, dyslipidemia, hypertension, diabetes mellitus, female sex, education status, and older age [7, 31, 35, 69–75]. Vascular risk factors will be discussed in detail below. Various clinical factors that are unique to the CKD population contribute to cognitive impairment. These include a high rate of undiagnosed depression and polypharmacy-related side effects or interactions [19, 20]. Patients with renal disease often have significant fatigue and daytime sleepiness related to poor sleep quality, which could contribute to further cognitive decline [76]. It should be noted that patients undergoing hemodialysis have many additional risk factors predisposing them to cognitive impairment, including the dialysis procedure itself. The dialysis procedure predisposes patients to potential risk factors for cognitive impairment and cerebrovascular disease including volume and electrolyte fluctuations, cerebral edema and hypoperfusion, and excessive cytokine release [60]. Interestingly, the frequency of hypotensive episodes during dialysis has been associated with cerebral atrophy and lacunae frequency, while microembolisms may contribute to the burden of both large and small vessel cerebrovascular disease although much research is needed in this area [77, 78]. Moreover, secondary and recurrent delirium (often related to hypoperfusion) and encephalopathy (i.e., untreated renal failure related neurotoxicity) appear to be associated with the development of cognitive impairment [79]. Finally, we recognize that anemia and derangements in serum vitamin D levels also contribute to the CKD milieu and potentially cognitive decline. In cross-sectional studies, anemia has been found to be associated with cognition in ESRD; however, in a longitudinal study, anemia was not an independent predictor of cognitive decline in elderly patients with CKD [80]. In terms of vitamin D, a review by Cheng et al. (2016) notes that reduced levels of 25(OH)-vitamin D may be contributing to cognitive impairment in CKD [81]. Clinical trials are needed to investigate the effect of vitamin D supplementation on cognitive outcomes.
7. The Cerebrovascular-Renal Axis (Figure 1)
The accelerated cognitive decline in older CKD patients appears to be due, in part, to the CKD disease process itself, which creates a toxic vascular and metabolic milieu that consists of chronic inflammation, oxidative stress, uremia, and systemic vascular endothelial dysfunction [82–88]. This toxic internal vascular and metabolic milieu is postulated to cause vascular dysfunction related impairment of the white matter that is superimposed on neurodegenerative damage caused by homocysteine, uremic toxins, creatinine, and cystatin C [62, 89]. Homocysteine appears to be an especially strong risk factor for stroke in CKD patients via a direct neurotoxic effect, initiation of systemic inflammation, and endothelial dysfunction [90–94]. The increase in homocysteine is probably due to reduced renal clearance. Unfortunately, interventions with folate to reduce homocysteine levels have thus far been conflicting and disappointing [95–97]. Patients with CKD have increased levels of oxidative stress, caused by uremia, production of reactive oxygen species via physiological pathways (e.g., impaired/damaged/malfunctioning mitochondria), and an inability to produce adequate antioxidative enzymes [98, 99]. These changes all contribute to a vascular milieu that consists of systemic inflammation, high levels of oxidative stress, and endothelial dysfunction that is unique to the CKD patient and creates a vascular pathway to cognitive decline.
Systemic and cerebral vasculature and cognition in CKD.
8. Vascular Mechanisms Related to Cognitive Decline in CKD
Patients with CKD are at an increased risk for vascular disease-related cognitive impairment rather than Alzheimer’s disease per se as described above. Vascular calcification in advanced stages of CKD, possibly including intracranial calcification, could be influencing cognition. Interestingly, there appears to be a significant influence of chronic hypertension on the progression of cognitive decline. This may be related to the high volume of blood flow and pressure that the brain and the kidney are exposed to.
The association between systemic arterial stiffness and cognitive performance has been established in cross-sectional studies [100]. More recently, Pase et al. (2016) studied the Framingham Offspring cohort and found that aortic stiffness predicts incident mild cognitive impairment and incident dementia in nondiabetic patients over 10 years [101]. Apart from aortic (central arterial) stiffness, stiffness in arteries in close proximity to the brain may need to be considered. One study reports that, in swines, carotid artery stiffness seems to be associated with impaired memory [102]. Additionally, although intracranial artery stiffness is even more challenging to measure, it may also be associated with cognitive decline [103].
Hypertension is associated with changes in brain tissue and cerebral vasculature. For example, mean arterial pressure was associated with white matter hyperintensity volume in the Framingham Offspring cohort, even in the absence of associations between changes in brain tissue and tonometry measures (such as arterial stiffness or central pulse pressure) [104]. Importantly, increased duration of hypertension is an important contributor to cognitive outcomes. Midlife hypertension has a significant impact on long-term cognitive impairment, as reviewed by Iadecola et al. (2016) [105]. Although some studies have shown a relationship between elevated blood pressure and cognitive impairment in the absence of a stroke, whether intensive hypertension control results in prevention or reversal of cognitive outcomes is unclear [106]. Upcoming results from the SPRINT-MIND trial (Systolic Blood Pressure Intervention Trial, Memory and Cognition in Decreased Hypertension) may address some of these unanswered questions.
The Strain Vessel Hypothesis states that “strain vessels” found in vital organs play a protective role [107]. Strain vessels help maintain a pressure gradient between the larger arteries and capillaries. High-pressure flow from large arteries, in addition to low resistance to flow in small vessels in vital organs, causes subsequent damage to vessels exposed to high pulsatility [108]. In the brain, small perforating arteries are exposed to high pressure; cerebral hemorrhage and infarction occur frequently in these small arteries [107, 109]. As decreasing kidney function is associated with arterial stiffness [110] and high blood pressure, patients with CKD are likely to have their blood vessels exposed to high pulsatility flow. Therefore, CKD patients are at high risk of developing injury to cerebral vasculature. The latter, in turn, would impact cognitive function.
It is challenging for drugs to influence the aorta and large arteries; and thus interventions may target other conduit arteries to reduce wave reflection. Although drugs such as angiotensin-converting enzyme inhibitors and calcium channel blockers seem to be beneficial in hypertensive elderly individuals, blood pressure levels that are optimal for cognitive function are yet to be identified [106]. Apart from medications, regular exercise may be employed to target this phenomenon.
9. Exercise as a Potential Therapeutic Approach
Higher levels of physical activity and cardiorespiratory fitness levels are associated with increased levels of cognitive function in healthy individuals. Exercise appears to prevent cerebral atrophy or even increase hippocampal volume in the general population [111, 112]. It is conjectured that these observations are related to an increase in brain-derived neurotrophic factor and an exercise-induced increase in angiogenesis, neurogenesis, and synaptogenesis. It is conceivable that physical activity and fitness levels are related to cognitive function in patients with kidney disease, but there have been a minimal number of studies in this area and the results are inconsistent. Patients on hemodialysis with the highest self-reported activity levels had the highest cognitive scores in one study [113]. Conversely, one smaller study found no association between maximal oxygen consumption and scores on the MMSE in patients on hemodialysis [114]. Several exercise intervention studies have shown promise in improving cognition in healthy elderly participants with and without MCI [111, 115–126], whereas others have reported no improvement [127–130]. Regular exercise and higher fitness levels in non-CKD patients with and without cognitive impairment have been associated with improved cognitive function, white matter integrity, and hippocampal volume suggesting a possible neuroprotective effect of exercise [111, 113, 115–125]. This is conjectured to be due to an improvement in vascular function-related increases in cerebral blood flow [116]. It is therefore plausible that exercise training may improve the vascular milieu and thereby contribute to improved cognitive function in patients with CKD. However, the impact of exercise on cognitive function in the CKD population is currently unknown. Only one study has reported on cognitive function following exercise training in the dialysis population. Martins et al., 2011, reported an improvement in cognitive function measured via the MMSE following exercise training [131]. Unfortunately, this study was not randomized and the MMSE is not a sensitive measure for change in global cognition, which limits any conclusions. Studies investigating the impact of exercise on cognition in CKD patients are needed. Exercise training appears to improve the vascular milieu in patients with CKD by reducing systemic inflammation and oxidative stress, arterial stiffness, and improving vascular function [132]. However, not all studies have shown improvements in these vascular risk factors, likely due to differences in sample characteristics, exercise program, and outcome measures. Moreover, exercise training may reduce traditional risk factors for cerebrovascular disease such as blood pressure and lipid profile although it should be noted that randomized controlled trials are scarce in patients with CKD and most data are based on secondary analyses from smaller trials. Exercise training is also known to improve glucose control in diabetic patients and may reduce homocysteine levels. Importantly, the pleiotropic effect of exercise provides additional benefits that are important to patients with CKD including improved quality of life, improved physical function, and reduced risk of frailty. Moreover, higher levels of physical activity have been associated with reduced risk of initiation of renal replacement therapy and higher survival rate in patients with CKD stages 3–5 [133]. Finally, emerging studies suggest that there is an independent association between prolonged sedentary time and kidney function decline, whereas higher levels of physical activity are associated with reduced levels of creatinine and lower risk of kidney impairment [134, 135]. Thus, it is plausible that exercise may affect renal function itself and thereby provide a protective effect. Despite lack of data on the impact of exercise on cognitive function, it is prudent for clinicians to recommend that patients with CKD consider initiating an exercise program and increase their daily physical activity levels to gain the mental and physical health benefits of exercise.
10. Summary and Conclusions
Cognitive impairment is common in patients with CKD and negatively affects health-related quality of life and other health-related outcomes. It is imperative that clinicians recognize the value of early screening for cognitive impairment and initiate preventive and treatment measures. Importantly, the decline in cognitive function appears to be multifaceted with a major involvement of vascular dysfunction in a unique CKD metabolic milieu that predisposes patients to an accelerated cognitive decline. Multidisciplinary healthcare teams are needed to provide psychosocial support and patient education on essential topics such as control of blood pressure, risks of polypharmacy, and other individualized self-care practices. Current research investigating exercise-induced improvement in cognition in non-CKD population is promising, but there are conflicting reports in the literature. As exercise training may be a plausible adjunctive therapeutic approach to improve cognitive outcomes and quality of life in patients with CKD, further research should focus on exercise as a promising approach that may retard the progression of cognitive impairment in CKD.
Conflicts of Interest
The authors declare that they have no conflicts of interest.
CoreshJ.SelvinE.StevensL. A.ManziJ.KusekJ. W.EggersP.Van LenteF.LeveyA. S.Prevalence of chronic kidney disease in the United States2007298172038204710.1001/jama.298.17.20382-s2.0-35848968871U.S. Renal Data SystemUSRDS 2013 annual data report2013Rodriguez-AngaritaC. E.Sanabria-ArenasR. M.Vargas-JaramilloJ. D.Ronderos-BoteroI.Cognitive impairment and depression in a population of patients with chronic kidney disease in colombia: a prevalence study20163, article 2610.1186/s40697-016-0116-7TamuraM. K.YaffeK.HsuC.-Y.YangJ.SozioS.FischerM.ChenJ.OjoA.DelucaJ.XieD.VittinghoffE.GoA. S.AppelL. J.FeldmanH. I.HeJ.KusekJ. W.LashJ. P.RahmanM.TownsendR. R.Cognitive Impairment and Progression of CKD2016681778310.1053/j.ajkd.2016.01.0262-s2.0-84959890797Kurella TamuraM.WadleyV.YaffeK.McClureL. A.HowardG.GoR.AllmanR. M.WarnockD. G.McClellanW.Kidney function and cognitive impairment in US adults: the reasons for geographic and racial differences in stroke (REGARDS) study200852222723410.1053/j.ajkd.2008.05.0042-s2.0-47149085499KurellaM.ChertowG. M.LuanJ.YaffeK.Cognitive impairment in chronic kidney disease200452111863186910.1111/j.1532-5415.2004.52508.x2-s2.0-16544390383KurellaM.ChertowG. M.FriedL. F.CummingsS. R.HarrisT.SimonsickE.SatterfieldS.AyonayonH.YaffeK.Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study20051672127213310.1681/asn.20050100052-s2.0-27744550471YaffeK.AckersonL.TamuraM. K.Le BlancP.KusekJ. W.SehgalA. R.CohenD.AndersonC.AppelL.DesalvoK.OjoA.SeligerS.RobinsonN.MakosG.GoA. S.Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive study201058233834510.1111/j.1532-5415.2009.02670.x2-s2.0-75749138969MurrayA. M.TupperD. E.KnopmanD. S.GilbertsonD. T.PedersonS. L.LiS.SmithG. E.HochhalterA. K.CollinsA. J.KaneR. L.Cognitive impairment in hemodialysis patients is common200667221622310.1212/01.wnl.0000225182.15532.402-s2.0-33747082695PhinneyA.Living with dementia from the patient's perspective19982468152-s2.0-0032083305SteemanE.AbrahamI. L.GodderisJ.Risk profiles for institutionalization in a cohort of elderly people with dementia or depression199711629530310.1016/S0883-9417(97)80002-72-s2.0-0031309504AndrieuS.ReynishE.NourhashemiF.Predictive factors of acute hospitalization in 134 patients with Alzheimer's disease: a one year prospective study2002175422NewcomerR.CovinskyK. E.ClayT.YaffeK.Predicting 12-month mortality for persons with dementia2003583S187S19810.1093/geronb/58.3.s1872-s2.0-0038331973WlodarczykJ. H.BrodatyH.HawthorneG.The relationship between quality of life, mini-mental state examination, and the instrumental activities of daily living in patients with Alzheimer's disease2004391253310.1016/j.archger.2003.12.0042-s2.0-2442718681SehgalA. R.GreyS. F.DeOreoP. B.WhitehouseP. J.Prevalence, recognition, and implications of mental impairment among hemodialysis patients1997301414910.1016/S0272-6386(97)90563-12-s2.0-0030786933WeinerD. E.SeligerS. L.Cognitive and physical function in chronic kidney disease201423329129710.1097/01.mnh.0000444821.87873.7b2-s2.0-84898547296SorensenE. P.SarnakM. J.TighiouartH.ScottT.GiangL. M.KirkpatrickB.LouK.WeinerD. E.The kidney disease quality of life cognitive function subscale and cognitive performance in maintenance hemodialysis patients201260341742610.1053/j.ajkd.2011.12.0292-s2.0-84865694794BremerB. A.WertK. M.DuricaA. L.WeaverA.Neuropsychological, physical, and psychosocial functioning of individuals with end-stage renal disease199719434835210.1007/BF028951532-s2.0-0031404118JungS.LeeY.-K.ChoiS. R.HwangS.-H.NohJ.-W.Relationship between cognitive impairment and depression in dialysis patients20135461447145310.3349/ymj.2013.54.6.14472-s2.0-84886545127FengL.YapK. B.NgT. P.Depressive symptoms in older adults with chronic kidney disease: mortality, quality of life outcomes, and correlates201321657057910.1016/j.jagp.2012.12.0202-s2.0-84880173442McAdams-DemarcoM. A.TanJ.SalterM. L.GrossA.MeoniL. A.JaarB. G.KaoW.-H. L.ParekhR. S.SegevD. L.SozioS. M.Frailty and cognitive function in incident hemodialysis patients201510122181218910.2215/CJN.019602152-s2.0-84957810567U.S. Renal Data System2006FolsteinM. F.FolsteinS. E.McHughP. R.‘Mini-mental state’. A practical method for grading the cognitive state of patients for the clinician197512318919810.1016/0022-3956(75)90026-62-s2.0-0016823810KnopmanD. S.BoeveB. F.PetersenR. C.Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia200378101290130810.4065/78.10.12902-s2.0-0141705380PetersenR. C.DoodyR.KurzA.MohsR. C.MorrisJ. C.RabinsP. V.RitchieK.RossorM.ThalL.WinbladB.Current concepts in mild cognitive impairment200158121985199210.1001/archneur.58.12.19852-s2.0-0035195760PetersenR. C.Mild cognitive impairment as a diagnostic entity2004256318319410.1111/j.1365-2796.2004.01388.x2-s2.0-4544335597American Psychiatric Associtation19944thWashington, DC, USAAmerican Psychiatric AssociationBossolaM.AntociccoM.Di StasioE.CiciarelliC.LucianiG.TazzaL.RosaF.OnderG.Mini Mental State Examination over time in chronic hemodialysis patients2011711505410.1016/j.jpsychores.2011.01.0012-s2.0-79958766804BuchmanA. S.TanneD.BoyleP. A.ShahR. C.LeurgansS. E.BennettD. A.Kidney function is associated with the rate of cognitive decline in the elderly2009731292092710.1212/WNL.0b013e3181b726292-s2.0-70349659527EtgenT.SanderD.ChoncholM.BriesenickC.PoppertH.FörstlH.BickelH.Chronic kidney disease is associated with incident cognitive impairment in the elderly: The INVADE study200924103144315010.1093/ndt/gfp2302-s2.0-70349488281KurellaM.MapesD. L.PortF. K.ChertowG. M.Correlates and outcomes of dementia among dialysis patients: the dialysis outcomes and practice patterns study20062192543254810.1093/ndt/gfl2752-s2.0-33750106233MurrayA. M.BarzilayJ. I.LovatoJ. F.WilliamsonJ. D.MillerM. E.MarcovinaS.LaunerL. J.Biomarkers of renal function and cognitive impairment in patients with diabetes20113481827183210.2337/dc11-01862-s2.0-84862832822YaffeK.LindquistK.ShlipakM. G.SimonsickE.FriedL.RosanoC.SatterfieldS.AtkinsonH.WindhamB. G.Kurella-TamuraM.Cystatin C as a marker of cognitive function in elders: findings from the Health ABC Study200863679880210.1002/ana.213832-s2.0-46749085524GeorgakisM. K.DimitriouN. G.KaralexiM. A.MihasC.NasothimiouE. G.TousoulisD.TsivgoulisG.PetridouE. T.Albuminuria in Association with Cognitive Function and Dementia: A Systematic Review and Meta-Analysis201710.1111/jgs.14750KurellaM.YaffeK.ShlipakM. G.WengerN. K.ChertowG. M.Chronic kidney disease and cognitive impairment in menopausal women2005451667610.1053/j.ajkd.2004.08.0442-s2.0-11144330925SajjadI.GrodsteinF.KangJ. H.CurhanG. C.LinJ.Kidney dysfunction and cognitive decline in women20127343744310.2215/CJN.053306112-s2.0-84863229480PasserJ. A.Cerebral atrophy in end-stage uremia1977791942-s2.0-0017583253KamataT.HishidaA.TakitaT.SawadaK.IkegayaN.MaruyamaY.MiyajimaH.KanekoE.Morphologic abnormalities in the brain of chronically hemodialyzed patients without cerebrovascular disease2000201273110.1159/0000135512-s2.0-0033956067SavazziG. M.CusmanoF.MusiniS.Cerebral imaging changes in patients with chronic renal failure treated conservatively or in hemodialysis2001891313610.1159/0000460402-s2.0-0034859966ChoA.-H.LeeS. B.HanS. J.ShonY.-M.YangD.-W.KimB. S.Impaired kidney function and cerebral microbleeds in patients with acute ischemic stroke200973201645164810.1212/WNL.0b013e3181c1defa2-s2.0-73449087633FazekasG.FazekasF.SchmidtR.KapellerP.OffenbacherH.KrejsG. J.Brain MRI findings and cognitive impairment in patients undergoing chronic hemodialysis treatment19951341-2838810.1016/0022-510X(95)00226-72-s2.0-0028800386ShimaH.IshimuraE.NaganumaT.YamazakiT.KobayashiI.ShidaraK.MoriK.TakemotoY.ShojiT.InabaM.OkamuraM.NakataniT.NishizawaY.Cerebral microbleeds in predialysis patients with chronic kidney disease20102551554155910.1093/ndt/gfp6942-s2.0-77951672609IkramM. A.VernooijM. W.HofmanA.NiessenW. J.Van Der LugtA.BretelerM. M. B.Kidney function is related to cerebral small vessel disease2008391556110.1161/STROKEAHA.107.4934942-s2.0-38149025706WadaM.NagasawaH.IsekiC.TakahashiY.SatoH.ArawakaS.KawanamiT.KuritaK.DaimonM.KatoT.Cerebral small vessel disease and chronic kidney disease (CKD): results of a cross-sectional study in community-based Japanese elderly20082721-2364210.1016/j.jns.2008.04.0292-s2.0-48349085759SedaghatS.CremersL. G. M.De GrootM.HoornE. J.HofmanA.Van Der LugtA.FrancoO. H.VernooijM. W.DehghanA.IkramM. A.Kidney function and microstructural integrity of brain white matter201585215416110.1212/WNL.00000000000017412-s2.0-84941964925TuladharA. M.van NordenA. G.de LaatK. F.ZwiersM. P.van DijkE. J.NorrisD. G.De LeeuwF.-E.White matter integrity in small vessel disease is related to cognition2015751852410.1016/j.nicl.2015.02.0032-s2.0-84923382648ChenH. J.ZhangL. J.LuG. M.Multimodality MRI findings in patients with end-stage renal disease201520151269740210.1155/2015/6974022-s2.0-84929629710OberlinL. E.VerstynenT. D.BurzynskaA. Z.VossM. W.PrakashR. S.Chaddock-HeymanL.WongC.FanningJ.AwickE.GotheN.PhillipsS. M.MaileyE.EhlersD.OlsonE.WojcickiT.McAuleyE.KramerA. F.EricksonK. I.White matter microstructure mediates the relationship between cardiorespiratory fitness and spatial working memory in older adults20161319110110.1016/j.neuroimage.2015.09.0532-s2.0-84951299728VernooijM. W.IkramM. A.VroomanH. A.WielopolskiP. A.KrestinG. P.HofmanA.NiessenW. J.Van Der LugtA.BretelerM. M. B.White Matter microstructural integrity and cognitive function in a general elderly population200966554555310.1001/archgenpsychiatry.2009.52-s2.0-65549146233ChouM.-C.HsiehT.-J.LinY.-L.HsiehY.-T.LiW.-Z.ChangJ.-M.KoC.-H.KaoE.-F.JawT.-S.LiuG.-C.Widespread white matter alterations in patients with end-stage renal disease: a voxelwise diffusion tensor imaging study201334101945195110.3174/ajnr.a35112-s2.0-84885412354KongX.WenJ.-Q.QiR.-F.LuoS.ZhongJ.-H.ChenH.-J.JiG.-J.LuG. M.ZhangL. J.Diffuse interstitial brain edema in patients with end-stage renal disease undergoing hemodialysis: A Tract-Based Spatial Statistics Study20149328, article e31310.1097/md.00000000000003132-s2.0-84920167096ZhangR.LiuK.YangL.ZhouT.QianS.LiB.PengZ.LiM.SangS.JiangQ.SunG.Reduced white matter integrity and cognitive deficits in maintenance hemodialysis ESRD patients: a diffusion-tensor study201425366166810.1007/s00330-014-3466-52-s2.0-84925493030KimH. S.ParkJ. W.BaiD. S.JeongJ. Y.HongJ. H.SonS. M.JangS. H.Diffusion tensor imaging findings in neurologically asymptomatic patients with end stage renal disease201129111111610.3233/NRE-2011-06842-s2.0-80052661011LamarM.ZhouX. J.CharltonR. A.DeanD.LittleD.DeoniS. C.In vivo quantification of white matter microstructure for use in aging: a focus on two emerging techniques201422211112110.1016/j.jagp.2013.08.0012-s2.0-84893137624ZhangL. J.WenJ.LiangX.QiR.SchoepfU. J.WichmannJ. L.MillikenC. M.ChenH. J.KongX.LuG. M.Brain default mode network changes after renal transplantation: a diffusion-tensor imaging and resting-state functional MR imaging study2016278248549510.1148/radiol.20151500042-s2.0-84955596072LaviS.GaitiniD.MilloulV.JacobG.Impaired cerebral CO2 vasoreactivity: association with endothelial dysfunction20062914H1856H186110.1152/ajpheart.00014.20062-s2.0-33749353561SedaghatS.VernooijM. W.LoehrerE.Mattace-RasoF. U. S.HofmanA.Van Der LugtA.FrancoO. H.DehghanA.IkramM. A.Kidney function and cerebral blood flow: The Rotterdam Study201627371572110.1681/asn.20141111182-s2.0-84959926269RadićJ.LjutićD.RadićM.KovačićV.Dodig-ĆurkovićK.ŠainM.Kidney transplantation improves cognitive and psychomotor functions in adult hemodialysis patients201134539940610.1159/000330849LauW. L.HuisaB. N.FisherM.the cerebrovascular-chronic kidney disease connection: perspectives and mechanisms201781677610.1007/s12975-016-0499-xLuR.KiernanM. C.MurrayA.RosnerM. H.RoncoC.Kidney-brain crosstalk in the acute and chronic setting2015111270771910.1038/nrneph.2015.1312-s2.0-84948119021MaderoM.GulA.SarnakM. J.Cognitive function in chronic kidney disease2008211293710.1111/j.1525-139X.2007.00384.x2-s2.0-38749140614BugnicourtJ.-M.GodefroyO.ChillonJ.-M.ChoukrounG.MassyZ. A.Cognitive disorders and dementia in CKD: the neglected kidney-brain axis201324335336310.1681/asn.20120505362-s2.0-84874591688KobayashiM.HirawaN.YatsuK.KobayashiY.YamamotoY.SakaS.AndohD.ToyaY.YasudaG.UmemuraS.Relationship between silent brain infarction and chronic kidney disease200924120120710.1093/ndt/gfn4192-s2.0-58049221186OvbiageleB.WingJ. J.MenonR. S.BurgessR. E.GibbonsM. C.SobotkaI.GermanL.SharaN. M.FernandezS.Jayam-TrouthA.EdwardsD. F.KidwellC. S.Association of chronic kidney disease with cerebral microbleeds in patients with primary intracerebral hemorrhage20134492409241310.1161/STROKEAHA.113.0019582-s2.0-84884478913MurrayA. M.Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden200815212313210.1053/j.ackd.2008.01.0102-s2.0-40449129236WangH.-H.HungS.-Y.SungJ.-M.HungK.-Y.WangJ.-D.Risk of stroke in long-term dialysis patients compared with the general population201463460461110.1053/j.ajkd.2013.10.0132-s2.0-84896976735FoleyR. N.GilbertsonD. T.MurrayT.CollinsA. J.Long interdialytic interval and mortality among patients receiving hemodialysis2011365121099110710.1056/nejmoa11033132-s2.0-80053069652HelmerC.StengelB.MetzgerM.FroissartM.MassyZ.-A.TzourioC.BerrC.DartiguesJ.-F.Chronic kidney disease, cognitive decline, and incident dementia: the 3C Study201177232043205110.1212/wnl.0b013e31823b47652-s2.0-82955225243GaxatteC.DarouxM.BlochJ.PuisieuxF.DeramecourtV.BoulangerE.Cognitive impairment and chronic kidney disease: which links?201171101710.1016/j.nephro.2010.09.0012-s2.0-79751530931UmemuraT.KawamuraT.UmegakiH.KawanoN.MashitaS.SakakibaraT.HottaN.SobueG.Association of chronic kidney disease and cerebral small vessel disease with cognitive impairment in elderly patients with type 2 diabetes20133121222210.1159/000351424PernaA. F.IngrossoD.ViolettiE.LucianoM. G.SepeI.LanzaD.CapassoR.AscioneE.RaiolaI.LombardiC.StenvinkelP.MassyZ.De SantoN. G.Hyperhomocysteinemia in uremia—a red flag in a disrupted circuit200922435135610.1111/j.1525-139x.2009.00579.x2-s2.0-69249133748SeligerS. L.GillenD. L.TirschwellD.WasseH.KestenbaumB. R.Stehman-BreenC. O.Risk factors for incident stroke among patients with end-stage renal disease200314102623263110.1097/01.ASN.0000088722.56342.A82-s2.0-0141566823WetmoreJ. B.EllerbeckE. F.MahnkenJ. D.PhadnisM.RiglerS. K.MukhopadhyayP.SpertusJ. A.ZhouX.HouQ.ShiremanT. I.Atrial fibrillation and risk of stroke in dialysis patients201323311211810.1016/j.annepidem.2012.12.0112-s2.0-84873419961GorelickP. B.BrodyJ.CohenD.Risk factors for dementia associated with multiple cerebral infarcts. A case-control analysis in predominantly African-American hospital-based patients1993507714720TamuraM. K.XieD.YaffeK.CohenD. L.TealV.KasnerS. E.MesséS. R.SehgalA. R.KusekJ.DeSalvoK. B.Cornish-ZirkerD.CohanJ.SeligerS. L.ChertowG. M.GoA. S.Vascular risk factors and cognitive impairment in chronic kidney disease: the Chronic Renal Insufficiency Cohort (CRIC) study20116224825610.2215/cjn.026603102-s2.0-79951885195IliescuE. A.CooH.McMurrayM. H.MeersC. L.QuinnM. M.SingerM. A.HopmanW. M.Quality of sleep and health-related quality of life in haemodialysis patients200318112613210.1093/ndt/18.1.1262-s2.0-12244259100DrosteD. W.KühneK.SchaeferR. M.RingelsteinE. B.Detection of microemboli in the subclavian vein of patients undergoing haemodialysis and haemodiafiltration using pulsed Doppler ultrasound200217346246610.1093/ndt/17.3.4622-s2.0-0036200670MizumasaT.HirakataH.YoshimitsuT.HirakataE.KuboM.KashiwagiM.TanakaH.KanaiH.FujimiS.IidaM.Dialysis-related hypotension as a cause of progressive frontal lobe atrophy in chronic hemodialysis patients: a 3-year prospective study2004971c23c3010.1159/0000775922-s2.0-2642587273BrounsR.De DeynP. P.Neurological complications in renal failure: a review2004107111610.1016/j.clineuro.2004.07.0122-s2.0-9344263421Kurella TamuraM.VittinghoffE.YangJ.GoA. S.SeligerS. L.KusekJ. W.LashJ.CohenD. L.SimonJ.BatumanV.OrdonezJ.MakosG.YaffeK.AppelL. J.FeldmanH. I.HeJ.LashJ. P.OjoA.RahmanM.TownsendR. R.Anemia and risk for cognitive decline in chronic kidney disease2016171, article 22610.1186/s12882-016-0226-62-s2.0-84957824459ChengZ.LinJ.QianQ.Role of vitamin D in cognitive function in chronic kidney disease201685, article 29110.3390/nu80502912-s2.0-84969130610HimmelfarbJ.Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy200922663664310.1111/j.1525-139X.2009.00659.x2-s2.0-71549120440SeligerS. L.LongstrethW. T.Jr.Lessons about brain vascular disease from another pulsating organ, the kidney20083915610.1161/STROKEAHA.107.4960002-s2.0-38349058059WardlawJ. M.SandercockP. A. G.DennisM. S.StarrJ.Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?200334380681110.1161/01.STR.0000058480.77236.B32-s2.0-0037338557KalimoH.Does chronic brain edema explain the consequences of cerebral small-vessel disease?20033438068122-s2.0-0037362697WeinerD. E.BartolomeiK.ScottT.PriceL. L.GriffithJ. L.RosenbergI.LeveyA. S.FolsteinM. F.SarnakM. J.Albuminuria, cognitive functioning, and white matter hyperintensities in homebound elders200953343844710.1053/j.ajkd.2008.08.0222-s2.0-60149105030BerrC.BalansardB.ArnaudJ.RousselA. M.AlperovitchA.Cognitive decline is associated with systemic oxidative stress: the EVA study. etude du vieillissement arteriel200048101285129110.1111/j.1532-5415.2000.tb02603.xIkizlerT. A.MorrowJ. D.RobertsL. J.EvansonJ. A.BeckerB.HakimR. M.ShyrY.HimmelfarbJ.Plasma F2-isoprostane levels are elevated in chronic hemodialysis patients200258319019710.5414/CNP581902-s2.0-0036707471De DeynP. P.VanholderR.ElootS.GlorieuxG.Guanidino compounds as uremic (neuro)toxins200922434034510.1111/j.1525-139X.2009.00577.x2-s2.0-69249155619AnanF.TakahashiN.ShimomuraT.ImagawaM.YufuK.NawataT.NakagawaM.YonemochiH.EshimaN.SaikawaT.YoshimatsuH.Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis200655565666110.1016/j.metabol.2005.12.0072-s2.0-33646039820FaßbenderK.MielkeO.BertschT.NafeB.FröschenS.HennericiM.Homocysteine in cerebral macroangiography and microangiopathy199935391641586158710.1016/s0140-6736(99)00309-82-s2.0-17444438459LiptonS. A.KimW.-K.ChoiY.-B.KumarS.D'EmiliaD. M.RayuduP. V.ArnellD. R.StamlerJ. S.Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor199794115923592810.1073/pnas.94.11.59232-s2.0-0030915272SeshadriS.WolfP. A.BeiserA. S.SelhubJ.AuR.JacquesP. F.YoshitaM.RosenbergI. H.D'AgostinoR. B.DeCarliC.Association of plasma total homocysteine levels with subclinical brain injury: cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study200865564264910.1001/archneur.65.5.6422-s2.0-43549091613WrightC. B.PaikM. C.BrownT. R.StablerS. P.AllenR. H.SaccoR. L.DeCarliC.Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan study20053661207121110.1161/01.str.0000165923.02318.222-s2.0-20444410004LeeM.HongK.-S.ChangS.-C.SaverJ. L.Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention: a meta-analysis20104161205121210.1161/strokeaha.109.5734102-s2.0-77953133802De JagerC. A.OulhajA.JacobyR.RefsumH.SmithA. D.Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial201227659260010.1002/gps.27582-s2.0-84859889194KwokT.LeeJ.LawC. B.A randomized placebo controlled trial of homocysteine lowering to reduce cognitive decline in older demented people201130329730210.1016/j.clnu.2010.12.004FujisakiK.TsuruyaK.YamatoM.ToyonagaJ.NoguchiH.NakanoT.TaniguchiM.TokumotoM.HirakataH.KitazonoT.Cerebral oxidative stress induces spatial working memory dysfunction in uremic mice: neuroprotective effect of tempol201429352953810.1093/ndt/gft3272-s2.0-84895762758SalisburyD.BronasU.Reactive oxygen and nitrogen species: impact on endothelial dysfunction2015641536610.1097/nnr.00000000000000682-s2.0-84919458832Zeki Al HazzouriA.YaffeK.Arterial stiffness and cognitive function in the elderly201442, supplement 4S503S51410.3233/jad-1415632-s2.0-84908173586PaseM. P.HimaliJ. J.MitchellG. F.BeiserA.MaillardP.TsaoC.LarsonM. G.DecarliC.VasanR. S.SeshadriS.Association of aortic stiffness with cognition and brain aging in young and middle-aged adults: The Framingham Third Generation Cohort Study201667351351910.1161/hypertensionaha.115.066102-s2.0-84958045110OlverT. D.KlakotskaiaD.FergusonB. S.HiemstraJ. A.SchachtmanT. R.LaughlinM. H.EmterC. A.Carotid artery vascular mechanics serve as biomarkers of cognitive dysfunction in aortic‐banded miniature swine that can be treated with an exercise intervention201655e00324810.1161/jaha.116.003248SunX.RundekT.Does increased arterial stiffness herald cognitive impairment?20164792171217210.1161/strokeaha.116.0142052-s2.0-84982795901TsaoC. W.HimaliJ. J.BeiserA. S.LarsonM. G.DecarliC.VasanR. S.MitchellG. F.SeshadriS.Association of arterial stiffness with progression of subclinical brain and cognitive disease201686761962610.1212/WNL.00000000000023682-s2.0-84959505052IadecolaC.YaffeK.BillerJ.BratzkeL. C.FaraciF. M.GorelickP. B.GulatiM.KamelH.KnopmanD. S.LaunerL. J.SaczynskiJ. S.SeshadriS.Zeki Al HazzouriA.Impact of hypertension on cognitive function: a scientific statement from the American Heart Association2016686e67e9410.1161/hyp.0000000000000053TadicM.CuspidiC.HeringD.Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden201616, article 20810.1186/s12872-016-0386-0ItoS.NagasawaT.AbeM.MoriT.Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk200932211512110.1038/hr.2008.272-s2.0-67650372806O'RourkeM. F.SafarM. E.Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy200546120020410.1161/01.hyp.0000168052.00426.652-s2.0-21744459081MitchellG. F.Van BuchemM. A.SigurdssonS.GotalJ. D.JonsdottirM. K.KjartanssonÓ.GarciaM.AspelundT.HarrisT. B.GudnasonV.LaunerL. J.Arterial stiffness, pressure and flow pulsatility and brain structure and function: The Age, Gene/Environment Susceptibility-Reykjavik Study2011134113398340710.1093/brain/awr2532-s2.0-81055144033TownsendR. R.WimmerN. J.ChirinosJ. A.ParsaA.WeirM.PerumalK.LashJ. P.ChenJ.SteigerwaltS. P.FlackJ.GoA. S.RafeyM.RahmanM.SheridanA.GadegbekuC. A.RobinsonN. A.JoffeM.Aortic PWV in chronic kidney disease: a CRIC ancillary study201023328228910.1038/ajh.2009.2402-s2.0-76749127509EricksonK. I.VossM. W.PrakashR. S.BasakC.SzaboA.ChaddockL.KimJ. S.HeoS.AlvesH.WhiteS. M.WojcickiT. R.MaileyE.VieiraV. J.MartinS. A.PenceB. D.WoodsJ. A.McAuleyE.KramerA. F.Exercise training increases size of hippocampus and improves memory201110873017302210.1073/pnas.10159501082-s2.0-79952611543WeuveJ.KangJ. H.MansonJ. E.BretelerM. M. B.WareJ. H.GrodsteinF.Physical activity, including walking, and cognitive function in older women2004292121454146110.1001/jama.292.12.14542-s2.0-4544370551Stringuetta-BelikF.ShiraishiF. G.Oliveira e SilvaV. R.BarrettiP.CaramoriJ. C. T.BôasP. J. F. V.MartinL. C.FrancoR. J. D. S.Greater level of physical activity associated with better cognitive function in hemodialysis in end stage renal disease20123443783862-s2.0-84893512627HsiehR.-L.LeeW.-C.ChangC.-H.Maximal cardiovascular fitness and its correlates in ambulatory hemodialysis patients2006481212710.1053/j.ajkd.2006.03.0812-s2.0-33745191893AhlskogJ. E.GedaY. E.Graff-RadfordN. R.PetersenR. C.Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging201186987688410.4065/mcp.2011.02522-s2.0-80052198680HayesS. M.AloscoM. L.FormanD. E.The effects of aerobic exercise on cognitive and neural decline in aging and cardiovascular disease20143428229010.1007/s13670-014-0101-x2-s2.0-84919932652SmithJ. C.NielsonK. A.WoodardJ. L.SeidenbergM.VerberM. D.DurgerianS.AntuonoP.ButtsA. M.HantkeN. C.LancasterM. A.RaoS. M.Does physical activity influence semantic memory activation in amnestic mild cognitive impairment?20111931606210.1016/j.pscychresns.2011.04.0012-s2.0-79957614591RuscheweyhR.WillemerC.KrügerK.DuningT.WarneckeT.SommerJ.VölkerK.HoH. V.MoorenF.KnechtS.FlöelA.Physical activity and memory functions: an interventional study20113271304131910.1016/j.neurobiolaging.2009.08.0012-s2.0-79955705244BakerL. D.FrankL. L.Foster-SchubertK.GreenP. S.WilkinsonC. W.McTiernanA.PlymateS. R.FishelM. A.WatsonG. S.CholertonB. A.DuncanG. E.MehtaP. D.CraftS.Effects of aerobic exercise on mild cognitive impairment: a controlled trial2010671717910.1001/archneurol.2009.3072-s2.0-74949118967NagamatsuL. S.ChanA.DavisJ. C.BeattieB. L.GrafP.VossM. W.SharmaD.Liu-AmbroseT.Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial201320131086189310.1155/2013/8618932-s2.0-84875461765Kirk-SanchezN. J.McGoughE. L.Physical exercise and cognitive performance in the elderly: current perspectives20139516210.2147/cia.s395062-s2.0-84890525351VossM. W.EricksonK. I.PrakashR. S.ChaddockL.KimJ. S.AlvesH.SzaboA.PhillipsS. M.WójcickiT. R.MaileyE. L.OlsonE. A.GotheN.Vieira-PotterV. J.MartinS. A.PenceB. D.CookM. D.WoodsJ. A.McAuleyE.KramerA. F.Neurobiological markers of exercise-related brain plasticity in older adults201328909910.1016/j.bbi.2012.10.0212-s2.0-84872200937ColcombeS. J.KramerA. F.EricksonK. I.ScalfP.McAuleyE.CohenN. J.WebbA.JeromeG. J.MarquezD. X.ElavskyS.Cardiovascular fitness, cortical plasticity, and aging200410193316332110.1073/pnas.04002661012-s2.0-12144290722BarnesD. E.Santos-ModesittW.PoelkeG.KramerA. F.CastroC.MiddletonL. E.YaffeK.The mental activity and exercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults2013173979780410.1001/jamainternmed.2013.1892-s2.0-84877773817LautenschlagerN. T.CoxK. L.FlickerL.FosterJ. K.Van BockxmeerF. M.XiaoJ.GreenopK. R.AlmeidaO. P.Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial200830091027103710.1001/jama.300.9.10272-s2.0-50949110086SmithP. J.BlumenthalJ. A.HoffmanB. M.CooperH.StraumanT. A.Welsh-BohmerK.BrowndykeJ. N.SherwoodA.Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials201072323925210.1097/psy.0b013e3181d146332-s2.0-77951447854BlumenthalJ. A.MaddenD. J.Effects of aerobic exercise training, age, and physical fitness on memory-search performance19883328028510.1037/0882-7974.3.3.2802-s2.0-0024073901LaurinD.VerreaultR.LindsayJ.MacPhersonK.RockwoodK.Physical activity and risk of cognitive impairment and dementia in elderly persons20015834985042-s2.0-0035107265WilliamsonJ. D.EspelandM.KritchevskyS. B.NewmanA. B.KingA. C.PahorM.GuralnikJ. M.PruittL. A.MillerM. E.Changes in cognitive function in a randomized trial of physical activity: results of the lifestyle interventions and independence for elders pilot study200964668869410.1093/gerona/glp0142-s2.0-66149157231OkumiyaK.MatsubayashiK.WadaT.KimuraS.DoiY.OzawaT.Effects of exercise on neurobehavioral function in community-dwelling older people more than 75 years of age199644556957210.1111/j.1532-5415.1996.tb01444.x2-s2.0-0029921588MartinsC. T.RamosG. S.GuaraldoS. A.UezimaC. B.MartinsJ. P.Ribeiro JuniorE.Comparison of cognitive function between patients on chronic hemodialysis who carry out assisted physical activity and inactive ones201133127302-s2.0-80052829399BronasU. G.Exercise training and reduction of cardiovascular disease risk factors in patients with chronic kidney disease200916644945810.1053/j.ackd.2009.07.0052-s2.0-70349556364ChenI.-R.WangS.-M.LiangC.-C.KuoH.-L.ChangC.-T.LiuJ.-H.LinH.-H.WangI.-K.YangY.-F.ChouC.-Y.HuangC.-C.Association of walking with survival and RRT among patients with CKD stages 3–52014971183118910.2215/cjn.098109132-s2.0-84921529024GuoV. Y.BrageS.EkelundU.GriffinS. J.SimmonsR. K.Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes: a prospective cohort analysis20163391222122910.1111/dme.128862-s2.0-84941133717LeeS.ShimadaH.LeeS.MakizakoH.DoiT.HaradaK.BaeS.HaradaK.HottaR.TsutsumimotoK.YoshidaD.NakakuboS.AnanY.ParkH.SuzukiT.Association between sedentary time and kidney function in community-dwelling elderly Japanese people201610.1111/ggi.12779