Case Reports in Dermatological Medicine
Volume 2016 (2016), Article ID 6451327, 3 pages
http://dx.doi.org/10.1155/2016/6451327

Case Report

Idiopathic Sporadic Onychomadesis of Toenails

Poonkiat Suchonwanit and Sunatra Nitayavardhana

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Received 15 February 2016; Revised 2 June 2016; Accepted 8 June 2016

Academic Editor: Ioannis D. Bassukas

Copyright © 2016 Poonkiat Suchonwanit and Sunatra Nitayavardhana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. Onychomadesis can be considered as a severe form of Beau’s line. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis in several toenails in the absence of predisposing factors or associated conditions. To the best of our knowledge, our patient is the first reported case of idiopathic onychomadesis limited to toenails.

1. Introduction

Onychomadesis is a clinical sign of nail plate separation due to transient or permanent arrest of nail matrix activities. In an early stage, the nail plate shows a transverse depression line (Beau’s line). If the nail matrix remains injured for a long period of time, then the line becomes deeper until splitting of the nail plate; as a result, shedding of the nail occurs (onychomadesis). Onychomadesis can be considered as a severe form of Beau’s line [1]. This condition usually occurs after trauma, causal diseases, or medications, yet it rarely occurs as an idiopathic condition. We report a case of a 38-year-old Thai female who developed recurrence onychomadesis in several toenails in the absence of predisposing factors or associated conditions.

2. Case Report

A 38-year-old Thai female presented with a 10-year history of asymptomatic shedding of several toenails. The symptom occurred in all toenails, usually in 1-2 nails at the same time. Nail shedding developed approximately 3-4 times per year from the proximal to the distal end, always returning to normal regrowth. Her fingernails were never affected. She had mild allergic rhinitis for more than 20 years which was well controlled. She reported taking oral antihistamines only for symptomatic treatment. She denied history of other systemic diseases or traumas prior to this condition. There were no family members having a similar problem. She preferred having manicure and pedicure with nail polish periodically.

Physical examination revealed the proximal separation of the right 4th toenail from the nail bed and shallow transverse grooves on the right 3rd and 4th toenails (Figure 1). There was no subungual hyperkeratosis and there were no periungual lesions. The cuticle was intact. Fingernails and other toenails were normal. All nails were partially stained by unremoved nail polish. There was no evidence of other dermatological conditions. Complete blood count, transaminases, blood urea nitrogen, creatinine, thyroid function tests, antinuclear antibody test, and urinalysis revealed no abnormalities. The patient refused performing a nail matrix biopsy due to fear of pain. According to the patient’s presentation, the diagnosis of idiopathic sporadic onychomadesis of toenails was performed. The patient was advised to practice gentle nail care and was asked to observe any events that may suggest the precipitating cause. The affected toenail improved at the 4-month follow-up visit (Figure 2).

Figure 1: Proximal separation of the right 4th toenail.

Figure 2: The affected toenail at the 4-month follow-up visit.

3. Discussion

Onychomadesis is characterized by nail plate separation from the nail bed. The condition begins at the proximal part of the nail, possibly caused by the temporary or permanent arrest of the nail matrix cell activities. This condition is considered a similar pathophysiology to Beau’s line, the transverse ridging of the nail plate, but it occurs in a higher degree of severity. The causes of onychomadesis can be idiopathic or associated with several conditions. The previous articles mostly reported that hand-foot-mouth disease, pemphigus vulgaris, and chemotherapeutic agents are the common associated conditions. Hardin and Haber have classified the associated conditions into autoimmune disease, other major medical illnesses, medication, neonatal illness, infection, and idiopathic cause [2].

Most of the reported cases associated the development of onychomadesis with the activity of systemic disease or using of a new drug. The clinical presentation is described as a temporary course with subsequent nail regrowth which affects several nails with the same degree of severity. On the other hand, onychomadesis occurring limited to single or a few nails suggests that the precipitating causes should directly affect the nail(s) including trauma or primary infection to the nail matrix. In our patient, she had a history of asymptomatic recurrent nail shedding in several toenails approximately 3-4 times per year and reported no association with health status, medications, or environmental factors. Nail changes randomly occurred, limited to 1-2 nails with spontaneous normal regrowth. The patient denied history of severe illness or trauma prior to this condition. Her presentation suggests the diagnosis of idiopathic onychomadesis.

The cases of idiopathic onychomadesis have been reported and can be classified as familial and sporadic. In 1897, Montgomery first reported a familial case of idiopathic onychomadesis [3]. Since then, there have been 3 reports of cases without underlying conditions presenting with periodic nails shedding and a family history, suggesting an autosomal dominant inheritance pattern [4–6]. Mehra et al. introduced the term idiopathic familial onychomadesis in 2000 for diagnosing this rare entity [6]. To our knowledge, there are 2 reports of nonfamilial idiopathic onychomadesis. The first case of idiopathic onychomadesis without a family history was reported by Venugopal and Murrell in 2009. They reported a 79-year-old Caucasian man who presented with seasonal fingernail shedding, usually in winter, for 10 years [7]. The other case was reported by Hardin and Haber in 2012. They described a 14-year-old Asian girl with a history of periodic shedding of her fingernails for 3 years and suggested the term idiopathic sporadic onychomadesis for the healthy patient with no family history and no seasonal nail shedding [8]. Our patient is the third reported case of idiopathic onychomadesis and fits the term idiopathic sporadic onychomadesis. Interestingly, idiopathic sporadic onychomadesis limited to toenails has never been reported before. Although the term “idiopathic” refers to unknown or uncertain cause, we hypothesize that microtrauma affecting those who have fragile nail matrix might play a role in the pathophysiology of idiopathic onychomadesis. The summary of previously reported cases is shown in Table 1.

Table 1: Clinical characteristics of previously reported cases of idiopathic onychomadesis.

Article
Age (Y)
Sex
Presenting symptom
Onset and duration
History of affected nail
Family history
Physical examination

Montgomery, 1897 [3]
35
Male
Shedding of nail plate
Infancy
Both
Yes
Right thumbnail loosened

Oliver, 1927 [4]
12
Male
Shedding of big toenail
2 years
Toenails
Yes
Right big toenail loosened

Martin and Rudolph, 1980 [5]
25
Male
Shedding of nail plate
Childhood
Both
Yes
All toenails loosened, with 7 affected fingernails

Mehra et al., 2000 [6]
12
Female
Asymptomatic nail shedding
4 months
Both
Yes
Separation of both 3rd fingernails, left 4th toenail, and right big toenail

Venugopal and Murrell, 2009 [7]
79
Male
Nail shedding every winter
10 years
Fingernails
No
Beau’s line of all fingernails with toenail dystrophy

Hardin and Haber, 2012 [8]
14
Female
Periodic shedding of fingernails 2-3 times/year
3 years
Fingernails
No
Separation of left thumbnail with intact nail plate

Present case
38
Female
Periodic shedding of toenails 3-4 times/year
10 years
Toenails
No
Separation of right 4th toenail

The pathophysiology of onychomadesis is still unknown. Inhibition or arrest of the nail matrix cell activities would be one explanation. Another explanation is that the matrix cell activities remain normal, but the nail plate quality changes by becoming thinner and shedding [9]. The history of systemic condition or drug usage is considered. Generally, there is no specific treatment for onychomadesis. However, investigation and correction of the underlying conditions are the most important strategies. Our patient was advised on the general nail care and was asked to observe any events that may discover the precipitating cause in the future. The prognosis in most cases of onychomadesis is excellent. This condition usually temporarily occurs and is followed by complete normal looking nail regrowth.

In conclusion, we herein present an interesting case of idiopathic sporadic onychomadesis. To the best of our knowledge, our patient is the first reported case of idiopathic onychomadesis limited to toenails. However, it is important for clinicians to investigate the underlying conditions in patients with onychomadesis.

Competing Interests

The authors declare that there are no competing interests regarding the publication of this paper.

References

B. M. Piraccini, M. Iorizzo, A. Antonucci, and A. Tosti, “Drug-induced nail abnormalities,” Expert Opinion on Drug Safety, vol. 3, no. 1, pp. 57–65, 2004.

J. Hardin and R. M. Haber, “Onychomadesis: literature review,” British Journal of Dermatology, vol. 172, no. 3, pp. 592–596, 2015.

D. Montgomery, “A case of hereditary and continuous shedding of the finger-nails,” The Journal of Cutaneous Diseases, vol. 12, pp. 252–256, 1897.

W. J. Oliver, “Recurrent onychoptosis occurring as a family disorder,” British Journal of Dermatology, vol. 39, no. 7, pp. 297–299, 1927.

S. Martin and A. H. Rudolph, “Familial dystrophic periodic shedding of the nails,” Cutis, vol. 25, no. 6, pp. 622–625, 1980.

A. Mehra, R. J. Murphy, and B. B. Wilson, “Idiopathic familial onychomadesis,” Journal of the American Academy of Dermatology, vol. 43, no. 2, part 2, pp. 349–350, 2000.

S. S. Venugopal and D. F. Murrell, “Seasonal onychomadesis in an elderly gentleman,” Dermatology Reports, vol. 1, no. 1, article e3, 2009.

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