First Case of Esophagitis Dissecans Superficialis in an HIV Patient: A Case Report and Literature Review

Esophagitis dissecans superficialis (EDS), a rare desquamative esophageal disease of uncertain etiology, is characterized by sloughing of fragments of esophageal mucosa. To the best of our knowledge, there has been no reported case of EDS in an HIV-infected patient. We report the first case of EDS in an adult HIV-infected male, who was hospitalized due to dysphagia. Esophagogastroscopy was performed, and the endoscopic findings together with the histopathologic findings of esophageal tissues were consistent with EDS. However, his symptom of dysphagia was not explained by EDS, but was the early symptoms of muscle-specific kinase (MuSK) myasthenia gravis (MG) that we finally diagnosed later by progression of the symptoms and electrophysiologic study. His symptoms had gradually improved after a course of intravenous immunoglobulin treatment. This is the first case of EDS and MuSK myasthenia gravis in an HIV-infected patient. A high index of suspicion of EDS should be made when taking care of the patients with desquamative or sloughing esophagitis especially with unknown etiology.


Introduction
Esophagitis dissecans superficialis (EDS), a very rare benign desquamative esophageal disease of uncertain etiology, is characterized by sloughing of large fragments of the esophageal squamous mucosa, followed by vomiting or regurgitation of the esophageal cast [1,2]. To date, there have been a few reported cases of EDS in the published literature; hence, accurate characterization of clinical features, etiology, pathologic findings, and outcomes are lacking [2]. We report herein the first human immunodeficiency virus-(HIV-) infected case with EDS and review all EDS case reports in the English literature.

Case Report
A 50-year-old male was hospitalized at Queen Savang Vadhana Memorial Hospital, Chonburi, ailand, due to a 3-week course of oropharyngeal dysphagia. He had been diagnosed with HIV infection with a CD4 cell count of 64 cells/mL (8%) 7 years prior, when he presented with a 2month history of chronic productive cough and significant weight loss. He received a combination treatment of tenofovir, emtricitabine, and efavirenz. Four months prior to the admission, he has achieved viral suppression with a CD4 count of 248 cells/mL (21%). Physical examination revealed neither oral candidiasis nor other intraoral lesions. Esophagogastroscopy was performed and revealed diffuse pseudomembranes in the lower one-third of the esophagus (Figure 1). e histopathologic findings of the biopsied esophageal mucosa exhibited mild acute and chronic esophagitis with focal squamous hyperplasia without demonstrated organisms. A presumptive diagnosis of candidal esophagitis was made, and fluconazole of 200 mg/day was prescribed to the patient. No clinical improvement was observed at 3 weeks after the start of antifungal treatment. Fluconazole dose was increased to 400 mg/day. ree weeks after high-dose fluconazole treatment, he was rehospitalized     due to worsening condition and development of hypovolemic hyponatremia. Esophagogastroscopy was done once again, which revealed circumferential white exudates with focal areas of erosions at the lower one-third of the esophagus without luminal stenosis or obstruction. e pathologic findings exhibited foci of splitting of the squamous epithelium with few intraepithelial cystic degenerations, no parakeratosis, no basal cell hyperplasia, mild acute and chronic inflammatory infiltrates with focal squamous cell hyperplasia, and normal underlying mucosa, which were similar to the previous findings ( Figure 2). A diagnosis of EDS was made, and omeprazole of 80 mg/day was given to the patient. e patient's symptoms gradually improved after 2 weeks of treatment. During hospitalization, he developed binocular diplopia, proximal muscle weakness, and ventilatory failure requiring ventilator support. Myasthenia gravis was suspected. e diagnosis was confirmed by an electrophysiologic study and positive result of musclespecific tyrosine kinase (muscle-specific kinase, MuSK). e patient gradually improved after a course of intravenous immunoglobulin treatment.

Discussion
To the best of our knowledge, this is the first case of EDS in an HIV-infected patient. EDS is a rare self-limited desquamative esophagitis of unknown etiology, usually affects adults after the age of 50 [1]. It is likely underestimated and frequently misdiagnosed as in our case. e diagnostic criteria of EDS have not been established yet; however, the endoscopic and pathologic criteria were recently proposed by Hart et al. including the presence of all of the following features: (1) the strip(s) of sloughed esophageal mucosa of >2 cm in length, (2) the normal underlying mucosa, and (3) the lack of ulcerations or friability of immediately adjacent mucosa [2]. e etiology of EDS is unknown. ere have been many reports demonstrating the association of EDS with (1) drugs including nonsteroidal anti-inflammatory drugs [1,3,4], bisphosphonates [5], potassium chloride [6], and clindamycin [7]; (2) celiac disease; and (3) autoimmune bullous dermatoses [6]. To date, there has been no report about the association of EDS and HIV infection, as in our case. Interestingly, due to lack of similar cases, the association between antiretroviral drugs and EDS required further studies. Similarly, the association between EDS and other immunodeficiency conditions has not been described. As a result, it is uncertain whether the HIV virus itself plays a role in the development of EDS. Furthermore, the association between EDS and MG also has never been reported. e presenting symptoms vary in different reports including dysphagia, heartburn, regurgitation, dyspepsia, upper gastrointestinal bleeding, anemia, and weight loss [2]. EDS is a benign condition that can resolve spontaneously or with the treatment with a proton-pump inhibitor (PPI) [1,4]. Our patient had protracted course of dysphagia for 6 weeks before clinical improvement with PPI treatment.

Conclusion
To the best of our knowledge, this is the first case of EDS in an HIV-infected patient. Due to lack of similar cases, the association between immunodeficiency conditions including antiretroviral drugs and EDS required further studies. EDS is a rare self-limited desquamative esophagitis of unknown etiology, which is diagnosed by excluding all other possible causes of oropharyngeal dysphagia. A high index of suspicion of EDS should be made when taking care of patients with desquamative or sloughing esophagitis especially with unknown etiology and/or no response to antifungal treatment.

Conflicts of Interest
e authors declare that they have no conflicts of interest.