Case Reports in Infectious Diseases
Volume 2020 (2020), Article ID 8828950, 4 pages
https://doi.org/10.1155/2020/8828950

Case Report

Oral Trypanosoma cruzi Transmission Resulting in Advanced Chagasic Cardiomyopathy in an 11-Month-Old Male

Melissa S. Nolan,¹ Joseane Elza Tonussi Mendes,2,3 Andres Ricardo Perez Riera,² and Gabriel Zorello Laporta²

¹Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
²Setor de Pós-graduação, Pesquisa e Inovação, Centro Universitário Saúde ABC, Fundação ABC, Santo André, São Paulo, Brazil
³Clínica do Coração, Cruzeiro do Sul, Acre, Brazil

Correspondence should be addressed to Melissa S. Nolan; msnolan@mailbox.sc.edu

Received 9 July 2020; Revised 9 September 2020; Accepted 3 October 2020; Published 17 October 2020

Academic Editor: Gernot Walder

Copyright © 2020 Melissa S. Nolan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Our case report describes the youngest clinical acute Chagas disease case and their unusual disease presentation of cardiac failure. In parts of the Brazilian Amazon, cultural practices include weaning infants from breastmilk to solid foods with açaí consumption serving as an intermediary. This practice could place infants at an increased risk of oral Trypanosoma cruzi infection and severe Chagasic cardiac disease.

1. Case Presentation

On January 6, 2018, a 5-month-old male presented with a 4-day history of fever to the emergency room at the Juruá Regional Hospital and was diagnosed with Plasmodium falciparum by microscopy. The patient was treated following the Brazilian Ministry of Health national treatment guidelines [1]: 3 days of twice daily Coartem (fixed combination of artemether (20 mg) and lumefantrine (120 mg)).

On June 25, 2018, the now 11-month-old male presented again to Juruá Regional Hospital with fever, upper abdominal pain, and shortness of breath. Anemia (hemoglobin = 10.9 g/dL) (anemia classification was unknown as mean corpuscular volume was not measured) and liver impairment (AST = 44 U/L; ALP = 134 U/L) were noted on blood exams. Thick blood smear microscopy showed Trypanosoma cruzi (T. cruzi) positive, and the patient was hospitalized. Furthermore, Chagas serology confirmed infection with an immunofluorescent test result of 1/160 IgG titration. After admission, a chest X-ray, electrocardiogram, and upper abdomen ultrasound were ordered. Chest X-ray confirmed cardiomegaly from an enlarged cardiac silhouette (cardiothoracic ratio = 62%) noted on a posteroanterior chest radiograph (Figure 1).

Figure 1: Posteroanterior chest radiograph depicting cardiothoracic ratio >50% by cardiac silhouette.

Electrocardiogram identified regular sinus rhythm (heart rate = 100 bpm), p-wave abnormalities suggestive of right atrial overload, and evidence of right ventricular overload (Figure 2). Hepatosplenomegaly was identified by ultrasound. The patient was diagnosed with “acute form of Chagas disease with cardiac involvement,” and a 60-day dosage of benznidazole in suspension was initiated. During the patient’s hospitalization, he took a twice daily 0.8 mL suspension of 25 mg tablets, tolerated the medication well, and exhibited normal liver enzymes on blood examination. After nine days, the patient made marked clinical improvement and was discharged home with a benznidazole prescription.

Figure 2: Electrocardiogram depicting electrocardiographic abnormalities.

On July 20, 2018, a 2D doppler echocardiogram with color flow was completed by the sole cardiologist in the region. Echocardiogram demonstrated significant right and left chamber enlargement, mild pericardial effusion, and a mild impairment (LVEF < 50%). The patient was given a once intravenous dosage of dobutamine and started on a daily cardiac failure treatment regimen: captopril, carvedilol, and furosemide. A follow-up appointment with his pediatrician on August 21 indicated the resolution of symptoms and lack of pathological findings on physical examination.

2. Discussion

This case report describes the youngest T. cruzi clinical case from suspected oral transmission and an unusual presentation of cardiac failure in an infant. This case originated from a rural Amazonian village in the region of Cruzeiro do Sul, Acre state, Brazil, a region with documented oral transmission outbreaks [2]. Local cultural practices include açaí juice consumption which began around 6 months of age to transition infants away from exclusive breastfeeding. Given the lack of palpebral edema or chagoma noted in the patient’s history and presenting illness, known as Chagas disease acute cases in the region, and consumption of a commonly contaminated source, oral acute T. cruzi transmission was suspected. Congenital transmission cannot be ruled out, as the mother was not tested at the time of the child’s diagnosis; however, the attending physician noted that the mother appeared healthy and was no longer breastfeeding. Fortunately, prompt antiparasitic treatment was administered likely preventing mortality, although sadly cardiac failure was not prevented in this 11-month-old male.

Chagas disease typically presents as a chronic organomegaly later in life, after decades of myocardial or smooth muscle tissue alteration and fibrotic damage [3]. Vectoral transmission in childhood traditionally presents as nonspecific flu-like illness with or without chagoma or palpebral swelling. In contrast, orally acquired T. cruzi infections demonstrate higher symptomatic rates, graver infections, and a higher number of cardiac involvement than vectoral acute infections [4–6]. Orally acquired T. cruzi infection from contaminated food products was first described in the 1960s [7], but a large outbreak stemming from a Venezuelan school [4] raised attention to the public health importance of this transmission source. Contaminated bacaba palm fruit juice, açaí pulp, and other food/beverage products have been linked to oral transmission outbreaks [6, 8–10]. In Venezuela and Brazil, oral T. cruzi outbreaks have been increasing over the past decade [5, 6, 11], thought to be linked to increased açaí commercial production in the region [12].

The pathophysiology of Chagas disease clinical progression is complex, largely multifactorial, and likely varies from patient to patient [3]. Higher parasite loads consumed in contaminated food/beverage products likely results in the increased pathogenicity of this transmission source [13]. Infecting parasite discrete typing unit and site of host tissue uptake are also theorized to influence the virulence of oral, acute disease [14, 15]. Another possible factor in our case’s clinical severity progression was his prior malarial infection. Plasmodium falciparum has been demonstrated to alter chemokine expression [16], which could impact subsequent parasitic infections acquired within a narrow timeframe. Additionally, fill and receipt of the remaining benznidazole dosage was not documented. Given the family’s financial strain, it is possible that the patient never completed the 60-day antiparasitic dosage, and the parasitic infection was never fully cleared allowing for continued pathology.

A large ECG study during a recent oral transmission outbreak suggests children are more likely than adults to experience acute electrocardiographic changes as a result of acute oral infection [5]. The permanent nature of the cardiac damage from our patient’s acute myocarditis is unusual; however, animal studies support the development of myocardial collagen and fibrotic tissue from oral infection routes [16], providing biological plausibility to our case’s clinical manifestation. Furthermore, a follow-up study of Venezuelan acute Chagas disease cases found that while benznidazole eliminated parasitemia, antiparasitic treatment had little effect on progressive myocardial processes eight months later [17]. A large multicenter prospective study of children with all cause myocarditis found that 39% received heart failure therapy one year postresolution of their initial myocarditis [18]. Therefore, one would expect to see more children needing heart failure medications after acute T. cruzi infections. The occurrence of these cases in low-resource settings likely influences the lack of prospective cardiac follow-up. Regardless, our case and the literature support the need to follow pediatric acute Chagas disease cases despite benznidazole receipt.

While ECG abnormalities are somewhat frequent in pediatric populations, cardiac failure has rarely been described in literature from vectoral and/or congenital transmission sources. A 7-month-old child with suspected vectoral transmission presented with acute Chagas myocarditis rapidly proceeding to death: this case never received Benznidazole, and diagnosis was not made until postmortem [19]. A 7-year-old child with vectoral transmission developed Chagas cardiomyopathy 3 months after a known triatomine exposure (chagoma presence); however, the exact timing of initial T. cruzi infection was unknown and speculated to have previously occurred due to epidemiologic family data [20]. A surveillance study in Mexico identified 14 cases aged 5–18 years with a history of vectoral transmission that presented with cardiomyopathy [21], providing further evidence that children can develop cardiomegaly within a short duration after infection. Lastly, a Bolivian congenital transmission study identified 11% of T. cruzi-positive newborns had cardiomegaly noted by chest radiography [22]. These collective cases suggest that children can develop cardiomegaly within a short timeframe, and it is imperative that all pediatric cases be followed for advanced clinical disease progression [23].

Overall, our case report demonstrates that infants can develop cardiomyopathy as a result of orally contaminated T. cruzi infection. Our case report makes evident the value of cardiac follow-up of acutely infected children after treatment. Finally, açaí products have been associated with multiple outbreaks in the Amazon region, and public health interventions requiring pasteurization should be implemented to prevent additional Chagas disease cases.

Data Availability

Our clinical case report is subject to privacy protection, and patient data are not available beyond which is listed in the current manuscript.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Authors’ Contributions

Melissa Nolan prepared the original draft and reviewed and edited the manuscript. Joseane Tonussi and Andres Perez conceptualized and investigated the study, provided resources, and reviewed and edited the manuscript. Gabriel Laporta visualized and supervised the study, contributed to data curation, and wrote, reviewed and edited the manuscript.

References

“Guia de tratamento da malaria no Brasil,” in Transmissíveis DdIeD, pp. 39–43, 1st edition, 2019, https://portalarquivos2.saude.gov.br/images/pdf/2020/janeiro/29/af-guia-tratamento-malaria-28jan20-isbn.pdf.

Distribuição dos Casos de Doença de Chagas Aguda, segundo UF de residência, 2008, http://www.saude.gov.br/saude-de-a-z/doenca-de-chagas#situacao.

A. Rassi Jr., A. Rassi, and J. A. Marin-Neto, “Chagas disease,” The Lancet, vol. 375, no. 9723, pp. 1388–1402, 2010.

B. Alarcón de Noya, Z. Díaz‐Bello, C. Colmenares et al., “Large urban outbreak of orally acquired acute Chagas disease at a school in Caracas, Venezuela,” The Journal of Infectious Diseases, vol. 201, no. 9, pp. 1308–1315, 2010.

J. Suarez, I. Mendoza, B. Noya, H. Acquatella, I. Palacios, and M. Marques-Mejias, “ECG manifestations of the biggest outbreak of Chagas disease due to oral infection in Latin-America,” Arquivos brasileiros de cardiologia, vol. 101, no. 3, pp. 249–254, 2013.

B. A. d. Noya, Z. Díaz-Bello, C. Colmenares et al., “Update on oral Chagas disease outbreaks in Venezuela: epidemiological, clinical and diagnostic approaches,” Memórias Do Instituto Oswaldo Cruz, vol. 110, no. 3, pp. 377–386, 2015.

N. N. Noya, D. T. Clausell, H. Nolibos et al., “Epidemic outbreak of Chagas disease probably due to oral contamination,” Revista do Instituto de Medicina Tropical de Sao Paulo, vol. 10, no. 5, pp. 265–276, 1968.

H. R. Esper, V. L. T. d. Freitas, J. G. P. L. Assy et al., “Fatal evolution of acute Chagas disease in a child from Northern Brazil: factors that determine poor prognosis,” Revista do Instituto de Medicina Tropical de São Paulo, vol. 61, p. e27, 2019.

R. A. G. França, M. G. V. B. Guerra, D. R Sousa et al., “Oral transmission of trypanosoma cruzi, Brazilian Amazon,” Emerging Infectious Diseases, vol. 25, no. 1, pp. 132–135, 2019.

A. A. GuerraFerreira, M. H. Garcia, E. Tatto et al., “Oral transmission of Chagas disease by consumption of açaí palm fruit, Brazil,” Emerging Infectious Diseases, vol. 15, no. 4, pp. 653–655, 2009.

V. Araujo, J. Meis, W. Savino et al., “Acute Chagas disease in the state of para, Amazon region: is it increasing?” Memorias do Instituto Oswaldo Cruz, vol. 113, no. 5, Article ID e170298, 2018.

Agricultura, pecuária e outros, Instituto Brasileiro de Geografia e Estatística, Rio de Janeiro, State of Rio de Janeiro, Brazil, 2019.

J. R. Coura, “The main sceneries of Chagas disease transmission. the vectors, blood and oral transmissions-a comprehensive review,” Memorias do Instituto Oswaldo Cruz, vol. 110, no. 3, pp. 277–282, 2015.

F. Y. Maeda, T. M. Clemente, S. Macedo, C. Cortez, and N. Yoshida, “Host cell invasion and oral infection by Trypanosoma cruzi strains of genetic groups TcI and TcIV from chagasic patients,” Parasites and Vectors, vol. 9, p. 189, 2016.

J. Barreto-de-Albuquerque, D. Silva-dos-Santos, A. R. Pérez et al., “Trypanosoma cruzi infection through the oral route promotes a severe infection in mice: new disease form from an old infection?” PLoS Neglected Tropical Diseases, vol. 9, no. 6, Article ID e0003849, 2015.

M. D. Perkins, A. F. Francisco, S. Jayawardhana, H. Langston, M. C. Taylor, and J. M. Kelly, “Imaging the development of chronic Chagas disease after oral transmission,” Scientific Reports, vol. 8, no. 1, p. 11292, 2018.

H. Parada, H. A. Carrasco, N. Añez, C. Fuenmayor, and I. Inglessis, “Cardiac involvement is a constant finding in acute Chagas’ disease: a clinical, parasitological and histopathological study,” International Journal of Cardiology, vol. 60, no. 1, pp. 49–54, 1997.

R. J. Butts, G. J. Boyle, S. R. Deshpande et al., “Characteristics of clinically diagnosed pediatric myocarditis in a contemporary multi-center cohort,” Pediatric Cardiology, vol. 38, no. 6, pp. 1175–1182, 2017.

D. H. Richmond, “Fatal cardiac failure in a 7-month-old child,” Pediatric and Developmental Pathology, vol. 6, no. 6, pp. 582–584, 2003.

N. Méndez-Domínguez, C. Chi-Méndez, J. Canto-Losa, A. Peniche-Echazarreta, J. P. Canto-Losa, and S. Gómez-Carro, “Cardiopatía Chagásica en un escolar: reporte de caso,” Revista chilena de pediatría, vol. 88, no. 5, pp. 647–651, 2017.

P. M. Salazar-Schettino, M. Cabrera-Bravo, C. Vazquez-Antona et al., “Chagas disease in Mexico: report of 14 cases of chagasic cardiomyopathy in children,” The Tohoku Journal of Experimental Medicine, vol. 240, no. 3, pp. 243–249, 2016.

F. Gomez, Y. Carlier, C. Truyens et al., “Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia,” The American Journal of Tropical Medicine and Hygiene, vol. 70, no. 2, pp. 201–209, 2004.

D. O. Ochiel, G. A. Awandare, C. C. Keller et al., “Differential regulation of β-chemokines in children with Plasmodium falciparum malaria,” Infection and Immunity, vol. 73, no. 7, pp. 4190–4197, 2005.