The interstitial part of the fallopian tube is the proximal portion located into the muscular wall of the uterus. Pregnancies implanting in this site are defined as interstitial or cornual [
The interstitial part of the tube has a significantly greater capacity to expand before rupture because of its thickness; rupture can result in catastrophic haemorrhage with massive blood loss from the vascular anastomoses between the uterine and the ovarian arteries (Sampson’s artery) [
Risk factors include assisted reproductive techniques, previous tubal pregnancies, tubal surgeries, a history of pelvic inflammatory disease, and sexually transmitted diseases [
Therefore, early detection is crucial to reduce morbidity and mortality.
Surgical approach consists of both laparotomy and laparoscopy techniques; conservative treatment is the administration of systemic methotrexate, checking the serum ß-hCG level on the 0th, the 4th, and the 7th day after, according to the Stovall protocol [
Three women were diagnosed with ectopic interstitial pregnancy from 2013 to 2016.
A 26-year-old woman (one previous Caesarean section and two previous voluntary terminations), with a history of irregular menstrual cycles, was admitted to the emergency unit with acute abdominal symptoms and vaginal bleeding. She was initially assessed by a general surgeon.
At first assessment, she presented with blood pressure of 70/40 mmHg and severe pallor; abdominal examination revealed guarding and tenderness in both iliac fossae and hypogastrium, while rectal examination revealed pain at the pressure of the pouch of Douglas. At ultrasound scan, corpusculated free fluid was detected. Laboratory test showed haemoglobin level of 10,1 g/dl. At vaginal examination, there was cervical tenderness with fullness in posterior fornix. Transvaginal ultrasound was not performed, since the patient conditions were worsening, and the general surgeon pushed to take the patient to the operating room, even though HCG test and the result of the CT were not ready.
Due to her unstable clinical conditions, the general surgeon decided on emergency laparotomy: subumbilical incision was performed, showing massive hemoperitoneum with blood loss from the uterine angle, due to a ruptured ectopic interstitial pregnancy (Figure
Resection of the cornual area combined with an ipsilateral salpingectomy was performed and a tobacco pouch suture (Figure
In the operating theatre, multiple arterial blood samples were taken, and a decreasing haemoglobin trend was noticed, with the minimum value of 6,3 g/dl. Plasma expanders, crystalloids, and two blood units were administered. Pregnancy test proved to be positive and CT scan showed massive hemoperitoneum, without detecting any masses in the uterus or adnexal regions.
The following days, serum ß-hCG level showed a decreasing trend (1212,3 UI/L-514,6 UI/L-228,3 UI/L). A week after the discharge, serum ß-hCG level was 8,8 UI/L.
The second woman, thirty years old, (one previous voluntary termination) was referred to the emergency obstetrics department with pelvic pain and vaginal bleeding in the past three days.
A blood sample for haemoglobin and ß-hCG levels was taken at admission, while a transvaginal scan revealed the presence of a round mass containing an embryo with positive heart beat located in the isthmic portion of left tube. Furthermore, a small amount of free fluid in the pouch of Douglas was noticed; ß-hCG level at the access was 482,80 UI/L. The patient was haemodynamically stable, without any signs or symptoms of acute abdomen.
After extensive counselling, elective laparoscopic left salpingectomy was performed (Figure
A third woman, thirty eight years old, (tertigravida, nullipara, one previous Caesarean section, and one previous voluntary termination) was admitted to the obstetrics and gynaecologic unit for vaginal blood loss and worsening pelvic pain. Laboratory tests and transvaginal ultrasound scan were immediately performed. The scan revealed the presence of a cornual anechoic mass with a hyperechoic border, compatible with tubal ring in the interstitial portion of the right tube, with maximum diameter of 0,87 cm, (Figure
In view of the stable clinical conditions and the woman’s wish to preserve the tube, intramuscular methotrexate was administered according to Stovall protocol [
Interstitial pregnancy is a rare form of ectopic pregnancy, located in the proximal part of the fallopian tube, which usually leads to uterine rupture with resultant life-threatening hemorrhage [
Major risk factors for interstitial pregnancies include assisted reproductive techniques, previous tubal pregnancy, tubal surgery, history of pelvic inflammatory disease, and sexually transmitted diseases [
Common symptoms of interstitial pregnancy are abdominal pain and vaginal bleeding, while signs of acute abdomen may occur in case of rupture and hemoperitoneum.
Haemorrhagic shock, due to interstitial pregnancy rupture, occurs in almost a quarter of the cases, thus explaining the relatively high mortality rate of interstitial pregnancies [
Early diagnosis is fundamental to manage this condition safely and it is accomplished using antenatal ultrasound and quantitative HCG assay.
Main diagnostic criteria using transvaginal ultrasound are as follows [
The paucity of the myometrium around the gestational sac is diagnostic of interstitial pregnancy, while an angular pregnancy has at least 5 mm of myometrium on all its sides [
Sonographic findings in two dimensions can be further confirmed using three-dimensional ultrasound, where available, to avoid misdiagnosis with early intrauterine or angular (implantation in the lateral angles of the uterine cavity) pregnancy [
Early diagnosis with transvaginal ultrasound allows conservative treatment with methotrexate; if it is made later in gestation, surgical treatment can be required [
Traditionally, the treatment of interstitial pregnancy involves hysterectomy or cornual resection, although more conservative approaches have been recently introduced.
Systemic methotrexate is safe and effective, but early recognition is essential. Local injection of methotrexate, either transvaginal or laparoscopic, provides highly effective methods [
Recent studies have reported that a pharmacological approach using methotrexate is usually effective, although there is insufficient evidence to recommend local or systemic approach.
Major institution recommends that methotrexate should be the first-line management for hemodynamically stable women with no pain, those with an unruptured ectopic pregnancy, a mass smaller than 35 mm with no visible heartbeat, and a serum b-hCG between 1500 and 5000 IU/l [
Other authors have reported an alternative approach by performing a transvaginal ultrasound guided aspiration of the extracelomic fluid from the gestational sac, followed by intrasaccular injection of 25 mg of methotrexate with/without 0.2–0.4 mEq of potassium chloride [
The main advantages of local injection of methotrexate include smaller drug dosage, fewer systemic side effects, and higher tissue concentration [
Surgical treatment consists of conservative techniques, such as laparoscopic cornual resection, laparoscopic or laparotomic cornuostomy or hysteroscopic removal of interstitial ectopic tissue, and radical operations such as salpingectomy [
Radical surgery is necessary in cases where haemorrhage is life threatening [
Due to the abundant blood supply in the cornual region from both uterine and ovarian vessels, rupture occurring after 12 weeks of gestation often leads to severe haemorrhage and eventually maternal death [
Laparotomy used to be the preferred surgical approach to the treatment of ruptured cornual pregnancy, especially when it occurs in advanced gestation [
Ipsilateral uterine artery ligation should be performed before attempting to repair a ruptured uterine cornu [
Even in women with ectopic pregnancy with significant hemoperitoneum, laparoscopic surgery has been reported to be safe in experienced hands [
Both Tulandi (1995) [
Most authors agree that the size of cornual gestation determines the best laparoscopic approach; Tulandi [
Various endoscopic approaches have been reported, such as electrocauterization, endoloop application, or the encircling suture before evacuation of the conceptus [
In a retrospective study, Moon et al. [
Other authors described other techniques such as the “purse-string” technique, a haemostatic suture passed at the base of the mass before removing it [
Hysteroscopic management can be particularly suitable for women who are reluctant to undergo medical treatment with methotrexate or in whom this treatment fails or is unavailable. Minelli et al. stated that, in expert hands, resection of the corneal endometrium, including the tubal ostium, can be successfully performed without perforation of the uterus [
Surgical treatment involving resection of the cornual region is associated with decreased fertility and increased uterine rupture rates in future pregnancies [
It is also described for uterine rupture in a pregnant woman with previous surgery of cornuostomy [
One of the concerns of future pregnancy is rupture of the interstitial portion of the tube (uterine rupture). The postulated mechanism is through a defective area of uterine wall [
Some authorities suggest suturing the uterine wall after surgical management to reinforce the defective area in the uterine wall. Term deliveries have, however, been reported following laparoscopic treatment of corneal pregnancy without reinforcing sutures [
Most authors agreed that Caesarean section should be the optimum mode of delivery for all pregnancies following cornual pregnancy [
The second concern after conservative management of cornual pregnancy is recurrence of ectopic pregnancy, particularly cornual pregnancy on the same side [
Thus, conservative treatment should be the first treatment option if the patient is stable and there is the aim to preserve fertility; otherwise interstitial pregnancy should be removed via laparoscopy or laparotomy.
However, more cases and studies should be reported; limitations of our case report study are based on the paucity of the patients.
Cornual pregnancy poses a significant diagnostic and therapeutic challenge; early diagnosis may help to choose the proper management and treatment; according to the clinical presentation and the haemodynamic stability, it should be based on laboratory exams (serum ß-hCG level) and transvaginal ultrasound.
The
Crown-rump length
Three-dimensional scan
Human chorionic gonadotropin.
We got an authorization from the hospital to collect and publish data for research activity; we obtained consent for publication of data from the patients.
The authors declare that they have no competing interests.
Dr. Spina Maria Roberta collected data and wrote the manuscript; Dr. Di Tizio Luciano contributed by collecting data and performing the two surgical interventions; Dr. Gustapane Sarah helped in collecting data; and Prof. D’Antonio Francesco and Prof. Liberati Marco supervised the manuscript.