Castleman’s disease also called angiofollicular lymph node hyperplasia, giant lymph node hyperplasia, or angiomatous lymphoid hamartoma is a nonneoplastic heterogeneous lymphoproliferative disorder. It can be classified into a localized form or as a multicentric disease with systemic symptoms. The association between Hodgkin’s lymphoma and Castleman’s disease is rare and has been well documented. The cases reported in the literature of Hodgkin’s lymphoma frequently were of the interfollicular subtype and coexisted with multicentric plasma cell variant of Castleman’s disease [
A 43-year-old man consulted in July 2009 for a neck pain with a solitary right cervical lymph node without general symptoms. He underwent a right adenectomy. Histological and immunohistochemical examinations concluded for features of plasma cell variant of Castleman’s disease with cells expressing CD3 and CD20 without expression of CD30 and CD15.
In August 2011 the patient presented an increase in the volume of cervical lymph node without fever or night sweats. Clinical examination revealed two cervical lymph nodes measuring 3 cm and 1 cm without organomegaly. Computerized tomography scan of cervical showed right cervical lymphadenopathy (Figure
Computed tomography scan of the cervical showed a right cervical lymphadenopathy measuring
Histological study of biopsy specimen showed that lymph node architecture is partially normal with presence of multiple lymphoid follicles. The Interfollicular tissue appears homogenized with a polymorphous population of cells composed of lymphocytes, histiocytes, and typical Reed-Sternberg cells (Figure
Microscopic findings of lymph node biopsy revealing (a) a preserved lymph node architecture with multiple lymphoid follicles, with or without hyalinized arteriolar (HESx40) and (b) typical Reed-Sternberg cells in the interfollicular.
In the immunohistochemical study, typical Reed-Sternberg cells were positive for CD15 and CD30 (Figure
Immunohistochemical analysis showing positive staining of the Reed-Sternberg cells for (a) CD15 and (b) CD30.
The bone marrow biopsy was normal. The erythrocyte sedimentation rate was 35 mm and the patient was seronegative for human immunodeficiency virus and for human herpesvirus type 8. Routine laboratory tests were normal.
The patient received four courses of chemotherapy based on the combination of anthracyclines, bleomycin, vinblastine and dacarbazine (ABVD) every 2 weeks. Evaluation by Cheson criteria after 4 courses of chemotherapy was in favor of a complete response (Figure
The assessment computed tomography scan of cervical after 4 cycles of chemotherapy showed a complete response.
Castleman’s disease is a nonneoplastic lymphoproliferative disorder that occurs throughout the body. Two classification systems exist for this disease: morphologic and histopathogenic classification. The morphologic classification is based on the extent of local lymph node involvement and distinguishes between unicentric and multicentric Castleman’s disease [
Unicentric Castleman’s disease was first described by Benjamin Castleman in 1956. He described 13 patients with hyaline vascular of Castleman’s disease in the chest. [
Histopathogenetic classification of Castleman’s disease includes the classic hyaline vascular type, plasma cell variant, or mixed type. Recent discoveries have classified plasma cell disease into two entities according to the presence of HHV-8 or not [
These histological subtypes are important and correlated with clinical syndromes: hyaline vascular Castleman’s disease is most often unicentric and usually asymptomatic. If symptoms are present, they are due to a mass effect of bulky lymphadenopathy. Hyaline vascular represents 90% of the cases of Castleman’s disease and is more frequently seen in young adults, with a median age in the third or fourth decade [
Contrary to the hyaline vascular form, plasma cell variant represents less than 10% of Castleman’s disease and can be localized (corresponding to 9% and 24% of the cases of localized Castleman’s disease) or more frequently multicentric [
HHV-8-associated Castleman’s disease is the plasmablastic variant of Castleman’s disease and is found mostly in HIV-positive patients. It is associated with constitutional symptoms, multicentric disease, aggressive course, and likelihood of developing lymphoma when compared to HHV-8-negative cases [
Tumor malignancies such as Kaposi’s sarcoma, non-hodgkin’s lymphoma, and rarely hodgkin’s lymphoma have been reported in the course of Castleman’s disease [
The pathogenesis of Castelman’s disease is not clear. Some authors hypothesized that cytokines especially interleukin-6 may be involved in causing interfollicular plasmocytosis seen in Castelman’s disease due to an increased IL-6 production by the germinal centres [
Because Castelman’s disease is rare and heterogeneous’s makes the standardization of treatment is more difficult. In localized form, the options include excision of the affected lymph nodes and radiation. In multicentric disease, effective therapy requires more extensive treatment based on corticosteroid, radiation therapy, and chemotherapy drugs such as CVP (cyclophosphamide, vincristine, and prednisone), CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), or monotherapy (chlorambucil, cyclophosphamide, 2-chlorodeoxyadenosine, carmustine, vincristine, bleomycin, liposomal doxorubicin, oral etoposide, and vinblastine) with varying degrees of response [
Targeting HHV-8 replication, CD20, and IL-6 was effective in this disease and durable responses were observed with Rituximab. Tocilizumab is an effective anti-IL-6R antibody that was approved in Japan for treatment of this entity [
Siltuximab, an anti-IL-6 antibody, is also effective and is a subject of prospective study in the USA and elsewhere [
Hodgkin lymphoma occurring within the context of Castleman’s disease should be treated with standard lymphoma chemotherapy regimen. Purging of CD20 positive cells with Rituximab might be beneficial by deprived Reed Sternberg cells of a survival factor [
In our case, the patient responded well to four courses of ABVD therapy then radiotherapy with complete remission after treatment.
Castleman’s disease is a rare heterogeneous entity with complex physiopathology. It has been associated with lymphoma especially when it is multicentric and associated with human immunodeficiency virus. Coexistence of Hodgkin lymphoma and Castelman’s disease is rare and not clear with a few cases reported in the literature. The management therapy for this entity is not standardized when it is confined in the literature to case reports and small case series.
The authors declare that they have no conflict of interests.
All the authors have made significant contributions enough diagnosis, treatment, and intellectual input of the cases and in writing the paper.