Case Reports in Orthopedics
Volume 2019 (2019), Article ID 4174985, 5 pages
https://doi.org/10.1155/2019/4174985

Case Report

Giant Protruding Nodular Fasciitis of the Anterior Chest Wall Clinically Mimicking a Soft Tissue Sarcoma

Hideyuki Kinoshita,¹ Tsukasa Yonemoto,¹ Hiroto Kamoda,¹ Yoko Hagiwara,¹ Toshinori Tsukanishi,¹ Sumihisa Orita,² Kazuhide Inage,² Naoya Hirosawa,² Seiji Ohtori,² and Takeshi Ishii¹

¹Department of Orthopedic Surgery, Chiba Cancer Center, 666-2 Nitonacho, Chuo-ku, Chiba 260-8717, Japan
²Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

Correspondence should be addressed to Hideyuki Kinoshita; kinoshi1783@yahoo.co.jp

Received 28 March 2019; Accepted 19 June 2019; Published 3 July 2019

Academic Editor: Johannes Mayr

Copyright © 2019 Hideyuki Kinoshita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Nodular fasciitis (NF) is a benign reactive proliferation of myofibroblasts that predominantly occurs subcutaneously. Commonly, it presents as a rapidly growing swelling in 4-8 weeks. NF mostly occurs in adults aged 20-50 years and usually has a . Giant NF with a is rare. Owing to its rapidly growing nature, a precise clinical diagnosis is difficult; it is frequently misdiagnosed as an aggressive or malignant tumor. Herein, we present the case of a 15-year-old male who presented with a large protruding mass on the anterior chest wall. The tumor appeared clinically malignant as it was protruding and had doubled in size within a few weeks, reaching approximately . Furthermore, the tumor separated and fell off spontaneously due to its large size. As the remaining tumor continued to grow rapidly, surgery was performed. Following wide tumor resection, no recurrence, metastases, or other complications were noted 1 year postsurgery. NF was diagnosed after pathological evaluation, including immunohistochemical analysis, molecular genetic testing, and cytogenetic testing via fluorescence in situ hybridization analysis. Knowledge of the atypical clinical course and a combination of histopathological examinations are necessary to accurately diagnose NF.

1. Introduction

Nodular fasciitis (NF) is described as a benign reactive proliferation of myofibroblasts. The exact etiology is still unknown, but a number of hypotheses regard preceding trauma or local irritation as an etiologic factor [1]. NF is fairly common in the soft tissues and most often presents as a small, solitary, and occasionally painful subcutaneous nodule that develops rapidly, often in 4-8 weeks. Contrastingly, NF rarely protrudes from the body surface [2]. Furthermore, NF lesions are usually less than 3-4 cm in diameter. Due to its rapidly growing nature, a precise clinical diagnosis is difficult, and the condition is frequently misdiagnosed as an aggressive or malignant tumor [3]. Recently, USP6 fluorescence in situ hybridization (FISH) analysis has been considered an important diagnostic tool for NF in conjunction with clinical and cytological findings [4].

Herein, we present a case of giant protruding NF of the anterior chest wall, clinically suspected to be a malignant tumor. Diagnosis and treatment were difficult due to the discrepancy between clinical features, such as the size and shape of the tumor, and the initial pathological results.

2. Case Presentation

A 15-year-old male patient presented to our orthopedic outpatient department with a rapidly enlarging protruding tumor on the left chest anterior wall, which had gradually increased in size over the preceding year. He had no history of preceding trauma or local irritation. The tumor was asymptomatic but was a physical obstacle due to its protruding nature. On examination, a protruding lesion was noted on the left chest wall, measuring approximately in size (Figure 1(a)). Magnetic resonance imaging revealed a tumor measuring , protruding subcutaneously superior to the clavicle (Figures 1(b) and 1(c)). Computed tomography revealed that the tumor had not invaded the clavicle. Histopathological examination following hematoxylin and eosin staining of the needle biopsy specimen revealed that the mass comprised fibromyxoid tissue with focal spindle cell proliferation and inflammation in a loosely myxoedematous matrix with extravasated red blood cells (Figure 2(a)). Further diagnostic testing via FISH analysis with a USP6 Dual Color Break Apart Probe was performed. FISH analysis revealed many USP6 rearrangements by splitting of the red and green signals in both nuclei in this field, strongly suggesting a diagnosis of NF (Figure 2(b)). Although the histopathological results did not match the clinical course, such as extremely rapid growth, he was followed up without treatment. The tumor size rapidly increased to , and the tumor protruded further in a few weeks. One month later, the tumor spontaneously separated and fell off (Figure 2(c)). The separated tumor measured approximately and was mostly a necrotic lesion with bleeding. Following this, the remaining tumor on the chest wall continued to grow rapidly (Figure 3(a)).

(a)

(b)

(c)

Figure 1: (a) Frontal view of the large protruding tumor, located on the anterior chest wall, measuring at the first visit. (b, c) Axial (b) and sagittal (c) view of the tumor (arrow) on T2-weighted magnetic resonance imaging.

(a)

(b)

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Figure 2: (a) The mass comprising fibromyxoid tissue with focal spindle cell proliferation and inflammation in a loosely myxoedematous matrix with extravasated red blood cells on hematoxylin and eosin (HE) staining. (b) Fluorescence in situ hybridization (FISH) analysis showing USP6 gene break-apart signals. (c) The tumor with necrosis that spontaneously separated and fell off (measuring ).

(a)

(b)

Figure 3: (a) Frontal view of the enlarging tumor with bleeding during the operation. (b) Wide excised specimen of the tumor, measuring approximately .

Although histopathological results confirmed the diagnosis of NF, the clinical findings, which included a protruding lesion that separated and fell off spontaneously, large tumor size, and rapid enlargement, suggested the possibility of malignancy, prompting the need for wide resection. Intraoperatively, we observed that the tumor had not invaded the muscle and bone. The postoperative period was uneventful. The resected tumor measured approximately (Figure 3(b)). Histopathological examination of the resected tumor following hematoxylin and eosin staining and FISH analysis with a USP6 Dual Color Break Apart Probe showed similar results as that of histopathological examination of the preoperative needle biopsy specimen. Furthermore, the fusion gene USP6-MYH9 was confirmed by polymerase chain reaction. These findings were consistent with a diagnosis of NF. After 1 year of follow-up, the patient did not show any recurrence, metastases, or other complications.

3. Discussion

NF is a benign reactive soft tissue lesion, frequently found in the subcutaneous tissues and muscle fascia, which shows proliferation of myofibroblasts and fibroblasts, and was first reported by Konwaller et al. in 1955 [5]. Most lesions are solitary and occur in adults 20–50 years of age and have equal incidence among sexes [6]. Reported lesions are usually less than 3–4 cm in diameter and rarely increase in size to more than 4 cm in diameter as occurred in the present case [7]. Bernstein et al. reported that lesions of NF rarely exceed 4 cm and 71% were smaller than 2 cm in their series comprising 134 cases [8]. Lesions may be found anywhere on the body but most commonly on the forearm (27-29%), back or chest wall (15-18%), and upper arm (12%) [3]. Intravascular fasciitis and cranial fasciitis are known subtypes of NF [9, 10]. While it is believed that local injury may play a role in fibroblastic proliferation, one study showed that only 10% of patients described a history of trauma [11]. Clinically, most patients have a history of a rapidly growing mass or nodule that has been present for only 1-2 weeks [12]. Although Majidi et al. reported a protruding NF of the auricle, NF rarely protrudes from the body surface [13]. In the current case, without a history of trauma, after the tumor gradually grew over one year, it grew rapidly into a huge protruding lesion in one month, suggesting the possibility of a malignancy. On a computed tomography scan, NF is seen as a relatively well-defined, soft tissue mass located superficially. On magnetic resonance imaging, NF has been described as inhomogeneous, hypointense to muscle on T1-weighted images, and hyperintense to fat on T2-weighted images, with variable enhancement.

NF lesions are classified into three subtypes according to the anatomical location: subcutaneous, fascial (intermuscular), and intramuscular. The subcutaneous form is most common, followed by the fascial form, with the intramuscular form being the least common [7]. Histologically, NF is usually a well-circumscribed yet nonencapsulated mass composed of fibroblastic and myofibroblastic proliferation arranged in short fascicles and untidy bundles. Typical histologic findings include a myxoid and, in some cases, highly cellular stroma, exhibiting abundant mitotic activity, with the absence of cellular atypia. Myxoid degeneration may also be observed, while other areas are more fibrotic and hyalinized, displaying evidence of adjacent microhemorrhage with granulation tissue [14]. Differential diagnoses are sarcoma with differentiation to myofibroblasts, such as low-grade myofibroblastic sarcoma, undifferentiated pleomorphic sarcoma, and deep fibrous histiocytoma. When it is difficult to diagnose definitely even with hematoxylin and eosin staining and immunohistochemical analysis, molecular genetic or cytogenetic testing for USP6 genetic rearrangements can be helpful to confirm the diagnosis [15]. In the present case, the lesion was diagnosed as NF with molecular genetic FISH analysis for USP6 genetic rearrangements. Shin et al. reported that USP6 FISH is a useful ancillary test in cases where NF is a potential diagnostic consideration [16].

Treatment options include observation and intralesional injection of steroids as spontaneous regression has been reported [1]. Although local marginal excision is by far the treatment modality most commonly opted for, chemotherapy and radiation therapy are not indicated. As recurrence after excision is very rare, in recurrent cases, other malignancies should be considered.

The diagnosis of NF is very challenging, often misdiagnosed as a sarcoma due to its rapid growth, rich cellularity, high mitotic activity, and poorly circumscribed nature. Plaza et al. reported that two-thirds of their cases had been misdiagnosed as sarcoma [17]. Therefore, the knowledge of the atypical clinical course of NF and a combination of these histopathological examinations including FISH analysis with a USP6 Dual Color Break Apart Probe are necessary for an accurate diagnosis.

In conclusion, the present report describes a case of giant NF protruding from the anterior chest wall, which was clinically suspected of being malignant owing to its atypical clinical course and appearance.

Ethical Approval

This study followed the Declaration of Helsinki.

Consent

Written informed consent was obtained from the patient for publication of this case report and the accompanying images.

Conflicts of Interest

The authors have no conflicts of interest directly relevant to the content of this article.

References

S. P. E. Nishi, N. V. Brey, and R. L. Sanchez, “Dermal nodular fasciitis: three case reports of the head and neck and literature review,” Journal of Cutaneous Pathology, vol. 33, no. 5, pp. 378–382, 2006.

G. J. R. Porter, A. J. Evans, A. H. S. Lee, L. J. Hamilton, and J. J. James, “Unusual benign breast lesions,” Clinical Radiology, vol. 61, no. 7, pp. 562–569, 2006.

V. Khanna, M. Rajan, T. Reddy, N. Alexander, and P. Surendran, “Nodular fasciitis mimicking a soft tissue sarcoma – a case report,” International Journal of Surgery Case Reports, vol. 44, pp. 29–32, 2018.

A. Kang, J. B. Kumar, A. Thomas, and A. G. Bourke, “A spontaneously resolving breast lesion: imaging and cytological findings of nodular fasciitis of the breast with FISH showing USP6 gene rearrangement,” BMJ Case Reports, vol. 2015, article bcr2015213076, 2015.

B. E. Konwaler, L. Keasbey, and L. Kaplan, “Subcutaneous pseudosarcomatous fibromatosis (fasciitis). Report of 8 cases,” American Journal of Clinical Pathology, vol. 25, no. 3, pp. 241–252, 1955.

B. J. Kleinstiver and H. A. Rodriguez, “Nodular fasciitis,” The Journal of Bone & Joint Surgery, vol. 50, no. 6, pp. 1204–1212, 1968.

A. Amaranathan, V. P. Ramakrishnaiah, S. Rajan, and R. N. Ganesh, “Giant intramuscular nodular fasciitis masquerading as soft tissue sarcoma with neural involvement - a case report,” Journal of Clinical and Diagnostic Research, vol. 10, no. 6, pp. 13–15, 2016.

K. E. Bernstein and R. Lattes, “Nodular (pseudosarcomatous) fasciitis, a nonrecurrent lesion: clinicopathologic study of 134 cases,” Cancer, vol. 49, no. 8, pp. 1668–1678, 1982.

A. S. Patchefsky and F. M. Enzinger, “Intravascular fasciitis: a report of 17 cases,” The American Journal of Surgical Pathology, vol. 5, no. 1, pp. 29–36, 1981.

D. H. Lauer and F. M. Enzinger, “Cranial fasciitis of childhood,” Cancer, vol. 45, no. 2, pp. 401–406, 1980.

P. Paliogiannis, A. Cossu, G. Palmieri et al., “Breast nodular fasciitis: a comprehensive review,” Breast Care, vol. 11, no. 4, pp. 270–274, 2016.

H. Erinanc and E. Türk, “The rare benign lesion that mimics a malignant tumor in breast parenchyma: nodular fasciitis of the breast,” Case Reports in Pathology, vol. 2018, Article ID 1612587, 3 pages, 2018.

M. R. Majidi, A. H. Jafarian, and S. Irani, “Nodular fasciitis of the auricle: a case report,” Iran Journal of Otorhinolaryngology, vol. 25, no. 71, pp. 115–118, 2013.

A. A. Souza, E. G. Cariri Neto, V. C. de Araújo, F. Passador-Santos, M. T. S. Alves, and A. B. Soares, “Description of a rare case of nodular fasciitis of the apical aspect of the upper buccal sulcus,” Case Reports in Dentistry, vol. 2016, Article ID 4231683, 4 pages, 2016.

J. A. Knight, K. N. Hunt, and J. Carter, “Nodular fasciitis of the breast in an elderly woman,” Radiology Case Reports, vol. 12, no. 4, pp. 642–644, 2017.

C. Shin, I. Low, D. Ng, P. Oei, C. Miles, and P. Symmans, “USP6 gene rearrangement in nodular fasciitis and histological mimics,” Histopathology, vol. 69, no. 5, pp. 784–791, 2016.

J. A. Plaza, J. Mayerson, and P. E. Wakely Jr., “Nodular fasciitis of the hand: apotential diagnostic pitfall in fine-needle aspiration cytopathology,” American Journal of Clinical Pathology, vol. 123, no. 3, pp. 388–393, 2005.