Ectopic intratracheal thyroid tissue (EITT) is a rare abnormality with only limited cases reported so far. The presenting symptoms can be very similar to those of bronchial asthma. We discuss the case of a 29-year-old man with subglottic ectopic thyroid, with a history of thyroid surgery for goiter, which has been managed with laser-assisted endoscopic approach. We have also included presenting symptoms, pathophysiology, diagnosis, and management of EITT. We aim to include EITT in the differentials of airway obstruction, particularly in those patients who have goiter or previous thyroid surgeries.
Ectopic thyroid tissue (ETT) is a rare entity, which can be seen anywhere in the midline from the base of the tongue to mediastinum. Among them, the laryngotracheal region has the rarest occurrence that can cause upper airway obstruction. Since ectopic intratracheal thyroid tissue (EITT) is a rare condition, its symptoms can easily be mistaken for those of asthma. An associated hypothyroid level can lead to enlargement of EITT and worsening of symptoms. We are discussing EITT-causing stridor in a young man with a history of thyroid surgery who missed thyroxine therapy.
A 29-year-old male, nonsmoker, presented to the emergency department with breathing difficulty. He had increasing dyspnea since few months, for which his general practitioner had treated him for asthma. Five years earlier, the patient had undergone thyroid surgery for goiter with subsequent thyroxine replacement therapy. But the patient missed the course and follow-up.
During the current presentation, fiber optic endoscopy showed bilateral mobile vocal cords and narrow infraglottic trachea with a right-sided subglottic mass.
CT showed subglottic soft tissue mass of about 4 × 4.7 × 2.4 cm in the craniocaudal, anteroposterior, and transverse dimensions, respectively, extending at the level of C4, C5, C6, and C7 vertebrae, and it causes marked narrowing of the airways (Figures
Contrast-enhanced CT showing subglottic soft tissue mass extending at the level of C4, C5, C6, C7 vertebrae, causing marked narrowing of the airways. (a) is axial view and (b) is coronal view.
On admission, TSH was 7.82 mIU/L (normal range 0.5–5.0 mIU/L) and free T4 was 13.31 mcg/dl (normal range 7.0–14.0 mcg/dl).
The patient underwent emergency tracheobronchoscopy which showed subglottic mass (Figure
Tracheo-laryngoscopic examination showing subglottic mass obstructing the airway.
We have done microlaryngoscopic excision of the subglottic mass utilizing CO2 laser. The histopathology confirmed ectopic thyroid tissue (Figures
Histopathology showing thyroid follicles filled with colloid.
Positive cytoplasmic staining with thyroglobulin immunostain confirming the thyroid origin.
Positive nuclear staining with TTF-1 immunostain confirming the thyroid origin.
Being a rare phenomenon, the number of cases reported with ETT so far is less than 500 [
The percentage of ETT in trachea contributes 6–7% of all primary endotracheal tumors [
The origin of EITT is explained by two theories. “The malformation theory” by Ziemssen in 1875 postulates that tracheal cartilage which develops later splits the thyroid gland, creating a small ectopic nest in the tracheal cavity [
Usually, patients are symptomless until a change in their hormonal status happen. Stimulatory factors including TSH, epidermal growth factor, and human chorionic gonadotropin could stimulate thyroid growth [
The findings suggestive of malignancy of EITT include multiple nodules, ulceration, and bleeding. 11% of EITT has been reported to undergo malignant transformation [
In a symptomatic patient, complete ENT examination should be carried out. Laboratory studies including thyroid assessment should also be conducted. Indirect laryngoscopy, flexible laryngoscopy, and CT and MR studies must be included. Radionuclide studies are highly sensitive and specific in detecting functional EITT [
If associated with multinodular goiter, FNAC can be done. Direct laryngobronchoscopy will help in proper visualization of mass and performing biopsy. Since there is a chance of severe hemorrhage, a biopsy should be carried carefully [
The factors determining management of EITT include the size of lesion, the patient’s age, the presence of local symptoms, the status of thyroid function, and histological findings. Surgical excision, radioiodine ablation, and thyroid suppression therapy are the main treatment options adapted. The complete surgical excision is indicated in symptomatic cases and in cases of histological malignancy. The two common surgical methods are removal via an endoscopic laser-assisted approach as in the present case and removal of the tumor via an open cricoid procedure [
Even though EITT is a rare abnormality with few case reported in the literature, it must be included in the differentials in patients presenting with airway obstruction, particularly in those who have goiters or previous thyroid surgeries.
The authors declare that there are no conflicts of interest.