Wheezing and cough are common case scenarios that pediatricians encountered in their office practices. Although a bronchogenic cyst is an uncommon condition, it is essential to be considered in the differential diagnosis of a chronic cough and wheezing among young children who fail to respond to appropriate medical treatment. A 28-month-old girl was referred to our pediatric pulmonology clinic with persistent symptoms of a cough and wheeze unresponsive to standard asthma therapy. This presentation prompted us to undertake a detailed diagnostic evaluation. The evaluation exposed a cystic mass in the middle mediastinum compressing the trachea and left main bronchus. The cyst was excised and confirmed pathologically to be a benign bronchogenic cyst. Subsequently, the patient recovered well and had been free of respiratory symptoms during follow-up visits. This report highlights one of the rare causes of wheezing and cough in young children and emphasizes the importance of considering it in the differential diagnosis of a child presenting with refractory asthma-like symptoms. This is important for early diagnosis and management and to avoid unpredictable complications of this treatable condition.
The common symptoms of asthma in children include a cough, wheeze, and breathing difficulties. If these symptoms persist over a period of asthma therapy or the symptoms are not typical for asthma, additional evaluation is strongly recommended.
Bronchogenic cysts (BCs) are a rare congenital malformation of the foregut that is typically found in the mediastinum [
We report on a child who presented with persistent wheeze and cough, not responding to medical treatment. Further investigation revealed that the cause of this child’s symptoms and signs was a bronchogenic cyst.
A 28-month-old girl was referred to our clinic because of a persistent cough, wheeze, and increased work of breathing for the preceding three months. Despite oral antibiotics and high doses of inhaled corticosteroids prescribed by her primary physician, cough and wheeze were persistent. Parents denied any history of witnessed foreign body aspiration, and there were no feeding-related symptoms. The patient was born at term with an uneventful postnatal course. Her history was significant for episodes of cough and intermittent wheeze that begun at one year of age; these episodes were usually treated with bronchodilators and inhaled steroids. There was no history of atopy in the family.
Initial physical examination revealed normal growth parameters, a respiratory rate of 40 breaths/minute, and no retractions. Oxygen saturation ranged from 94 to 95% on room air, and she was afebrile. Lung auscultation revealed decreased air exchange in the left lung; the rest of her physical examination was normal.
A chest X-ray was performed for abnormal breath sounds and showed hyperlucency of the left lung (Figure
Chest X-ray showing hyperinflation on the left side.
Blood work, including routine hematology and biochemistry tests, was within normal limits. Results of virology PCR for CMV, EBV, and adenovirus were negative. Acid-fast bacilli smear, culture, and TB PCR were negative.
On flexible bronchoscopy examination of her lower airways, no foreign body was seen, but significant external nonpulsatile compression over the left main bronchus was noticed; the rest of the airway anatomy was normal. This finding prompted us to undertake a detailed evaluation. Thoracic computed tomography (CT) scan and angiogram showed a soft tissue mass in the middle mediastinum, compressing the carina and proximal part of the right and left main bronchi, more pronounced on the left main bronchus (Figure
(a) CT scan of the chest showing a hypodense cystic lesion in the middle mediastinum (arrow), causing compression on the carina and the proximal aspect of the mainstem bronchi, more pronounced on the left main bronchus. (b) 3D reconstruction of the CT scan showing a significant narrowing of the left main bronchus (arrow), caused by external compression of the adjacent cystic lesion.
MRI of the chest showing lobulated mass lesion heterogeneously hypointense on T1-weighted images (arrow) (a), and hyperintense on T2-weighted images (arrow) (b). The mass is in the middle mediastinum, at the level of the carina and adjacent to the trachea extending to the subcarinal region, causing compression on the carina and both main bronchi, more pronounced on the left main bronchus.
These findings were in favor of the diagnosis of a bronchogenic cyst in the middle mediastinum. Therefore, the patient underwent thoracotomy and surgical removal of a cystic mass which was found during surgery to be adjacent to the posterior trachea and left main bronchus. Pathological examination of the mass showed a cystic lesion lined by the ciliated columnar epithelium surrounded by a fibromuscular wall containing the cartilage and nests of bronchial submucosal glands, confirming the probable diagnosis of a bronchogenic cyst. There was no evidence of malignancy.
The postoperative course was uneventful. The patient had been free of any respiratory symptoms and signs, including a cough and wheezing in the subsequent follow-up visits.
This child presented with a persistent cough and wheeze that were not responding to standard asthma treatment. We considered the causes of wheezing and coughing in children. Therefore, she underwent flexible bronchoscopy, CT scan, and magnetic resonance imaging (MRI) of the chest that revealed a bronchogenic cyst in the middle mediastinum. Surgical removal of the mass was successfully performed, and pathologic examination confirmed the diagnosis of the bronchogenic cyst.
Bronchogenic cyst (BC) is a rare congenital pulmonary malformation with a prevalence of 1 : 42,000–1 : 68,000 [
Ribet et al. reported that BCs were symptomatic in 70.8% of affected children [
Diagnostic studies include chest X-ray, barium swallow, bronchoscopy, and CT scan/MRI of the chest. A chest radiograph is diagnosed in only 77% of cases [
In conclusion, although a chronic cough and wheeze are common symptoms of asthma in children when these symptoms do not respond to conventional treatment strategies, this should prompt the clinician to seek further investigations looking for other causes of persistent “asthma-like symptoms.” Bronchogenic cysts are an uncommon developmental anomaly of the tracheobronchial tree, which may cause airway compression and mimic asthma. Pediatricians should consider bronchogenic cyst as an important asthma masquerader, particularly in young children who have persistent symptoms and inadequate response to asthma therapy. Surgical resection remains the treatment of choice in all cases to confirm the diagnosis and to prevent unpredicted complications.
Ethical approval and consent to participate were obtained from the Medical Research Center at Hamad General Hospital with Reference number 16329/16.
Written informed consent to participate was obtained from the parents.
The authors declare that they do not have financial or nonfinancial conflicts of interest to disclose.
Bronchogenic cyst
Gastroesophageal reflux
Polymerase chain reaction
Cytomegalovirus
Epstein-Barr virus
Tuberculosis
Chest computed tomography scan
Magnetic resonance imaging of the chest.