Case Reports in Surgery
Volume 2018 (2018), Article ID 6292789, 4 pages
https://doi.org/10.1155/2018/6292789

Case Report

Duodenal Gangliocytic Paraganglioma Requiring a Pancreaticoduodenectomy: A Case Report and Review of the Literature

Laurie Adams,¹ Theodore M. Friedman,² Timothy R. Shaver,³ and George Younan³

¹Department of Surgery, Inova Fairfax Hospital, Fairfax, VA, USA
²Department of Pathology, Inova Fair Oaks Hospital, Fairfax, VA, USA
³Division of Hepato-Pancreato-Biliary Surgery, Virginia Surgery Associates, Fairfax, VA, USA

Correspondence should be addressed to George Younan; grg.younan@gmail.com

Received 15 May 2018; Accepted 2 August 2018; Published 26 September 2018

Academic Editor: Beth A. Schrope

Copyright © 2018 Laurie Adams et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Introduction. Duodenal gangliocytic paragangliomas (GPs) are a subclass of duodenal neuroendocrine neoplasms and are exceedingly rare. They have been associated with an indolent behavior; however, they can rarely metastasize. Radical resection like a pancreaticoduodenectomy is sometimes indicated. We hereby present a case requiring major surgery and perform a literature search about this disease. Presentation of Case. A 49-year-old Caucasian female, who presented with an upper gastrointestinal bleed, was found to have a hypodense mass in the second/third portion of the duodenum. A biopsy of the mass during upper endoscopy was inconclusive. A pancreaticoduodenectomy was recommended based on the high suspicion for a duodenal adenocarcinoma and was performed successfully. Her final pathology revealed a duodenal gangliocytic paraganglioma. Discussion. The majority of duodenal GPs present as gastrointestinal bleeds while others less commonly present with anemia, abdominal pain, duodenal obstructive symptoms, pancreatitis, or abnormal incidental findings on axial abdominal imaging. Duodenal GPs were initially viewed as benign tumors of the duodenum; however, there have been increasing incidence reports of hematogenous and lymphatic metastasis. Appropriate treatment of duodenal GPs is still controversial and ranges from local endoscopic submucosal resection to major radical surgery. Conclusion. Duodenal GPs are very rare tumors of the second portion of the duodenum presenting with upper gastrointestinal bleeding and local symptoms of surrounding organs. Local or radical resection is usually recommended to prevent bleeding and the minor risk of metastatic spread.

1. Introduction

Duodenal neuroendocrine tumors (NETs) are infrequent, comprising about 1–3% of gastrointestinal endocrine tumors [1, 2]. Duodenal gangliocytic paragangliomas are a subclass of duodenal neuroendocrine neoplasms, ranking third in frequency behind gastrinomas and somatostatinomas of the duodenum, comprising about 10% of those, and most commonly arising from the second portion of the duodenum [3]. GPs were first described more than seventy years ago, and since then, they have been reported as small series or case reports in about two hundred publications [4]. Although thought to be benign entities, reports have demonstrated their malignant potential, either by spread to regional lymph nodes or metastasis to distant organs [5–7]. The World Health Organization (WHO) published a new classification of gastrointestinal neuroendocrine tumors in 2010 based on their mitotic activity and their Ki-67 proliferation index, regardless of their site of origin, so as to classify them into low-grade, intermediate-grade, and high-grade tumors [8–10]. Duodenal GPs should be differentiated from low-grade NET as they have a more indolent clinical behavior and improved prognosis [11–13]. We hereby present a case of upper gastrointestinal bleeding from an ulcerated duodenal mass, requiring a pancreaticoduodenectomy, and found to be a duodenal GP on final pathology examination.

2. Case Presentation

A 49-year-old Caucasian woman presented to the emergency room with three-day history of palpitations, shortness of breath, pallor, and black tarry stools. She was found to be anemic with hemoglobin of 4.4 g/dL. She was transfused, and a gastrointestinal bleeding workup was initiated. The rest of the physical examination and additional blood tests were within normal limits. A computed tomography (CT) scan of the abdomen showed a possible hypodense mass in the second/third portion of the duodenum that is intraluminal with an extraluminal component abutting the uncinate process of the pancreas. There was no sign of any other disease in the abdomen and lower chest (Figure 1). Colonoscopy was negative, and upper endoscopy showed an ulcerated mass in the second/third portion of the duodenum worrisome for duodenal adenocarcinoma (Figure 2). The mass was not bleeding at the time of the endoscopy. A biopsy of the mass done during endoscopy was inconclusive and showed cellular debris. The patient stabilized and stopped bleeding and was discharged home. She was electively seen at the hepatobiliary surgery clinic where additional staging workup was negative, including tumor markers. The patient’s personal and family history were noncontributory. A pancreaticoduodenectomy was recommended based on the suspicion for a duodenal adenocarcinoma and was successfully performed. She had an uneventful hospital stay and was discharged home on postoperative day five. Her final pathology revealed a duodenal gangliocytic paraganglioma eroding into the pancreas, and all lymph nodes were negative for tumor. She was seen eight months postoperatively and was still free of disease.

(a)

(b)

Figure 1: Axial (a) and coronal (b) computed tomography images of the duodenal GP, appearing as a hypodense lesion, shown to arise from the second/third portion of the duodenum and abut the uncinate process of the pancreas. Tumor is marked by an asterisk.

(a)

(b)

Figure 2: Endoscopic images of the large ulcerated mass found in the second/third portion of the duodenum. There was no bleeding stigmata at the time of endoscopy.

3. Discussion

Duodenal GPs were described initially by Dahl et al. in 1957, and they were given their current name in 1971 by Kepes et al. [4, 14]. After the WHO introduced the new classification of gastrointestinal NETs, there has been an argumentative question as to classify GPs as low-grade NETs or allow them their independent entity based on better clinical behavior and better prognosis [9, 11, 12].

The clinical presentation of duodenal GPs varies, with upper gastrointestinal bleeding occurring in almost half of the patients (as in the case of our patient), while 15% present with anemia [15]. Abdominal pain, obstructive duodenal symptoms, pancreatitis, and abnormal incidental findings on axial abdominal imaging account for the rest of the clinical presentations [16, 17]. The local tumor symptoms are likely due to its predilection to the second portion of the duodenum in 90% of the cases [15]. It affects patients of all ages with an average age of diagnosis of 52 years, and there is a little more preponderance towards occurrence in males [15].

GP are composed of three cell types: (1) epithelioid cells resembling well-differentiated neuroendocrine tumors or paraganglioma in both cytologic and architectural features; (2) spindled cells resembling those seen in peripheral nerve sheath tumors; and (3) ganglion-like cells with characteristic abundant cytoplasm and prominent nucleoli (Figure 3). The cell types exhibit differential immunohistochemical staining patterns as well. Epithelioid cells are positive for neuroendocrine markers such as synaptophysin and chromogranin and are frequently positive for keratins (Figure 4(a)). Ganglion-like cells are positive only for synaptophysin. Spindle cells are positive for S100 (Figure 4(b)). The cell components can vary in distribution, delineation, and relative proportions within a tumor. There can be an intimate admixture as shown in Figure 3(a), as well as regions composed predominately of one cell type which can be essentially identical in morphology to a well-differentiated NET (Figure 3(b)). This heterogeneity can potentially lead to misdiagnosis of GP, particularly on biopsy, if the other cellular components of GP are not recognized.

(a)

(b)

Figure 3: Hematoxylin and eosin (H&E) slides of our case report specimen, seen under low- and high-power magnification in (a) and (b), demonstrating the presence of three different cell types: epithelioid cells, spindle cells, and ganglion-like cells.

(a)

(b)

Figure 4: Pathology slides stained with immunohistochemistry. Synaptophysin stain, shown in (a), demonstrates epithelioid-type cells. Spindle cells stain positive for S100 in (b).

Duodenal GPs were initially viewed as benign behaving tumors of the duodenum; however, there has been an increasing incidence of reports about lymph node metastasis and distant organ metastasis [7, 18, 19]. There has even been a report of a mortality directly related to a case of metastatic duodenal GP after resection [6]. Surgical resection and endoscopic resection were the only two curative methods used historically in treating these tumors, and the permanent pathological examination was the gold standard to obtain a correct and precise diagnosis. There was only one report of a case that received adjuvant radiation [20]. Local recurrence after resection has been extremely rare and was reported only once in the literature [21]. Appropriate treatment of duodenal GPs is still controversial. Some authors suggest that local endoscopic or surgical resection is sufficient due to the very low rate of lymph node metastasis and local recurrence. Other authors report the importance of a radical resection with a pancreaticoduodenectomy for a better lymph node basin clearance and prevention of the low number, yet, clinically significant metastatic rate [12, 15, 22].

4. Conclusion

Duodenal GP are rare tumors of the second portion of the duodenum that present with upper gastrointestinal bleeding and local obstructive symptoms of surrounding organs. They are classified as rare neuroendocrine neoplasms of the gastrointestinal tract and are usually considered benign and assigned an excellent prognosis. Appropriate methods of treatment are still controversial but range from endoscopic submucosal resection to pancreaticoduodenectomy.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

References

K. M. Hoffmann, M. Furukawa, and R. T. Jensen, “Duodenal neuroendocrine tumors: classification, functional syndromes, diagnosis and medical treatment,” Best Practice & Research. Clinical Gastroenterology, vol. 19, no. 5, pp. 675–697, 2005.

I. M. Modlin, K. D. Lye, and M. Kidd, “A 5-decade analysis of 13, 715 carcinoid tumors,” Cancer, vol. 97, no. 4, pp. 934–959, 2003.

B. Wang, Y. Zou, H. Zhang, L. Xu, X. Jiang, and K. Sun, “Duodenal gangliocytic paraganglioma: report of two cases and review of literature,” International Journal of Clinical and Experimental Pathology, vol. 8, no. 9, pp. 9752–9759, 2015.

E. V. Dahl, J. M. Waugh, and D. C. Dahlin, “Gastrointestinal ganglioneuromas: brief review with report of a duodenal ganglioneuroma,” The American Journal of Pathology, vol. 33, no. 5, pp. 953–965, 1957.

S. J. Cathcart, A. R. Sasson, J. A. Kozel, J. M. Oliveto, and Q. P. Ly, “Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases,” World Journal of Clinical Cases, vol. 5, no. 6, pp. 222–233, 2017.

B. Li, Y. Li, X. Y. Tian, B. N. Luo, and Z. Li, “Malignant gangliocytic paraganglioma of the duodenum with distant metastases and a lethal course,” World Journal of Gastroenterology, vol. 20, no. 41, pp. 15454–15461, 2014.

C. Rowsell, N. Coburn, and R. Chetty, “Gangliocytic paraganglioma: a rare case with metastases of all 3 elements to liver and lymph nodes,” Annals of Diagnostic Pathology, vol. 15, no. 6, pp. 467–471, 2011.

K. Öberg, “Neuroendocrine tumors (NETs): historical overview and epidemiology,” Tumori Journal, vol. 96, no. 5, pp. 797–801, 2010.

K. E. Öberg, “Gastrointestinal neuroendocrine tumors,” Annals of Oncology, vol. 21, Supplement 7, pp. vii72–vii80, 2010.

K. Oberg, “Neuroendocrine tumors: recent progress in diagnosis and treatment,” Endocrine-Related Cancer, vol. 18, Supplement 1, pp. E3–E6, 2011.

Y. Okubo, “Gangliocytic paraganglioma is often misdiagnosed as neuroendocrine tumor G1,” Archives of Pathology & Laboratory Medicine, vol. 141, no. 10, p. 1309, 2017.

Y. Okubo, T. Nemoto, M. Wakayama et al., “Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan,” BMC Cancer, vol. 15, no. 1, p. 269, 2015.

Y. Okubo, “Gangliocytic paraganglioma: a diagnostic pitfall of rare neuroendocrine tumor,” Endocrine Pathology, vol. 28, no. 2, p. 186, 2017.

J. J. Kepes and D. L. Zacharias, “Gangliocytic paragangliomas of the duodenum. A report of two cases with light and electron microscopic examination,” Cancer, vol. 27, no. 1, pp. 61–70, 1971.

Y. Okubo, M. Wakayama, T. Nemoto et al., “Literature survey on epidemiology and pathology of gangliocytic paraganglioma,” BMC Cancer, vol. 11, no. 1, p. 187, 2011.

S. Sharma, B. L. Gaspar, P. Kumar, T. D. Yadav, and R. K. Vasishta, “Gangliocytic paraganglioma with atypical immunohistochemical features presenting as extrahepatic biliary obstruction,” International Journal of Surgical Pathology, vol. 23, no. 7, pp. 561–566, 2015.

N. I. Asimakopoulou, P. E. Papakonstantinou, K. G. Lasithiotakis et al., “Recurrent episodes of acute pancreatitis due to duodenal gangliocytic paraganglioma: report of a case,” Journal of the Pancreas, vol. 15, no. 2, pp. 201–205, 2014.

K. Nonaka, Y. Matsuda, A. Okaniwa, A. Kasajima, H. Sasano, and T. Arai, “Pancreatic gangliocytic paraganglioma harboring lymph node metastasis: a case report and literature review,” Diagnostic Pathology, vol. 12, no. 1, p. 57, 2017.

H. K. Park and H. S. Han, “Duodenal gangliocytic paraganglioma with lymph node metastasis,” Archives of Pathology & Laboratory Medicine, vol. 140, no. 1, pp. 94–98, 2016.

A. Wong, A. R. Miller, J. Metter, and C. R. Thomas, “Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature,” World Journal of Surgical Oncology, vol. 3, no. 1, p. 15, 2005.

D. B. Dookhan, M. Miettinen, G. Finkel, and Z. Gibas, “Recurrent duodenal gangliocytic paraganglioma with lymph node metastases,” Histopathology, vol. 22, no. 4, pp. 399–401, 1993.

B. W. Scheithauer, F. E. Nora, J. Lechago et al., “Duodenal gangliocytic paraganglioma. clinicopathologic and immunocytochemical study of 11 cases,” American Journal of Clinical Pathology, vol. 86, no. 5, pp. 559–565, 1986.