Evidence-Based Complementary and Alternative Medicine

Volume 2013 (2013), Article ID 253479, 2 pages

http://dx.doi.org/10.1155/2013/253479

Erratum

Erratum to “Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension”

Xin-Fang Leong,1,2 Mohd Rais Mustafa,³ and Kamsiah Jaarin¹

¹Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

²Department of Clinical Oral Biology (Pharmacology), Faculty of Dentistry, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

³Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia

Received 21 May 2013; Accepted 22 May 2013

Copyright © 2013 Xin-Fang Leong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The part related to “patients with mild hypertension ” was incorrectly indicated as “100 mg/kg and 200 mg/kg” in Table 1; here it is corrected.

Table 1: Significant cardiovascular effects of NS and its constituents.

Reference
Study model
Constituents
Laboratory findings

Renovascular hypertensive rat
NS oil (i.p.)

0.2 mL/kg
↓ SBP, tissue MDA, luminol, and lucigenin CL

↑ tissue Na⁺ and K⁺-ATPase

↓ plasma CK, LDH, and ADMA

↑ plasma NO

Rat
(a) NS oil (i.v.)

    4–32 μL/kg

(b) TQ (i.v.)

    0.2–1.6 mg/kg
↓ arterial BP and heart rate

(dose dependent)

Guinea pig
NS oil (i.v.)

4–32 μL/kg
↓ arterial BP and heart rate

(dose dependent)

Rat
(a) De-TQ volatile oil (i.v.)

    2–16 μL/kg

(b) α-pinene (i.v.)

    1–4 μL/kg

(c) p-cymene (i.v.)

    2–16 μL/kg
↓ arterial BP and heart rate

(dose dependent)

*De-TQ volatile oil and p-cymene:

4, 8, and 16 μL/kg

*α-pinene:

2 and 4 μL/kg

Rat
Thymol

(in vitro)
↓ aortic contraction

(dose dependent)

Canine and guinea pig
Thymol

(in vitro)
Negative inotropic action

(dose dependent)

Spontaneously hypertensive rat
NS seed extract (p.o.)

0.6 mL/kg
↑ diuresis

↓ arterial BP

Spontaneously hypertensive rat
NS extract (p.o.)

↓ SBP

↑ GFR, urinary, and electrolyte output

L-NAME-induced

hypertensive rat
TQ (p.o.)

0.5 mg/kg and

1 mg/kg
↓ SBP and serum creatinine

↑ kidney GSH

L-NAME-induced hypertensive rat
NS seed extract (p.o.)

400 mg/kg
↓ arterial BP, SBP, DBP, and serum LDH

↑ serum NO

Patients with mild hypertension
NS seed extract (p.o.)

100 mg twice per day,

200 mg twice per day
↓ SBP and DBP

(dose dependent)

↓ total and LDL cholesterol

NS: Nigella sativa; L-NAME: L-NG-nitroarginine methyl ester; i.p.: intraperitoneal; i.v.: intravenous; p.o.: per os; TQ: thymoquinone; De-TQ: de-thymoquinonated; SBP: systolic blood pressure; DBP: diastolic blood pressure; MDA: malondialdehyde; CL: chemiluminescence; CK: creatine kinase; LDH: lactate dehydrogenase; ADMA: asymmetric dimethylarginine; NO: nitric oxide; GFR: glomerular filtration rate; GSH: glutathione; LDL: low-density lipoprotein.