%PDF-1.4
%
2 0 obj
<>stream
q
/GS1 gs
BT
/F1 1 Tf
7.9701 0 0 7.9701 50.58 736.248 Tm
0 0 0 1 k
-0.0134 Tc
0 Tw
[(Hi)-13(n)-8.4(d)-17.3(a)4.4(w)-17.2(i)-240(P)-13.9(u)-8.6(b)-6.8(l)-13.3(i)-9.6(s)-8.9(h)-13.5(i)-13(n)-5(g)-242.1(C)-28.2(or)-24.1(p)-22.4(o)-1.4(r)-13.9(a)5.5(t)-17.8(i)-13(on)]TJ
0 -1.1879 TD
0.0001 Tc
[(IS)12.2(RN)-226.9(N)24.9(e)0.5(ur)13.1(o)6.5(l)0.2(og)-23.1(y)]TJ
0 -1.1868 TD
-0.0011 Tc
[(V)95.5(o)5.3(l)11.4(u)-0.8(me)-228.8()-5.9()2.9(,)-229.3(A)2.2(r)-11.8(t)-5.5(icle)-227.7(ID)-228.2()10.1()8.7()-13.2( )-1(,)]TJ
0 g
13.0876 0 TD
0.0145 Tc
( )Tj
0 0 0 1 k
1.2139 0 TD
0.0045 Tc
[(pa)8.8(g)12.9(e)4.9(s)]TJ
0 g
-14.3016 -1.1879 TD
-0.0012 Tc
[(h)17.9(t)9.1(t)9.1(p)-1.2(://)38.5(d)-1.7(x.do)10.8(i.o)10.8(r)6.2(g/./)-6(/)10()-5.7()8.6()-13.3( )]TJ
/F2 1 Tf
17.9328 0 0 17.9328 50.58 641.784 Tm
0 0 0 1 k
-0.0028 Tc
[(Re)-6.8(v)-16(i)1.2(e)-6.8(w)-231.2(A)27.3(r)-21.7(t)6.1(i)1.2(c)9.3(l)1.3(e)]TJ
/F3 1 Tf
0 -1.3335 TD
0.0001 Tc
[(Neurochemical)-248.9(a)0.3(nd)-249.9(Behavioral)-249.9(F)0.1(eatures)-249.8(i)0(n)-250(G)0(enetic)-249.4(Absence)]TJ
0 -1.1112 TD
[(Epilepsy)-249.1(a)0.3(nd)-250.4(in)-249.5(Acutely)-249.6(I)0.2(nduced)-249.4(A)0.2(bsence)-249.5(S)0.2(eizures)]TJ
11.9551 0 0 11.9551 86.697 549.525 Tm
[(A.)-208.1(S.)-208.1(Bazyan)]TJ
7.9701 0 0 7.9701 148.347 554.781 Tm
0 Tc
(1)Tj
11.9551 0 0 11.9551 155.313 549.525 Tm
0.0002 Tc
[(and)-208.1(G)-0.2(.)-208(van)-207(Luijtelaar)]TJ
7.9701 0 0 7.9701 261.342 554.781 Tm
0 Tc
(2)Tj
/F2 1 Tf
5.9776 0 0 5.9776 86.688 533.415 Tm
()Tj
8.9664 0 0 8.9664 90.927 529.473 Tm
-0.0003 Tc
[(I)38.6(n)-0.3(s)9.5(t)8.6(i)13.7(t)8.6(u)13.8(t)9.6(e)-228.6(o)11(f)-230.2(H)39.1(i)9.7(g)0.1(h)6.8(e)-0.8(r)-229.5(N)29.2(er)-20.7(vo)10(us)-229.4(A)29.3(c)-4.7(t)8.6(i)14.7(v)-13(i)13.7(ty)-228.8(a)15.9(n)6.7(d)-229(N)29.2(eu)12.8(r)18.4(o)9(p)9.9(h)24.9(ys)9.5(io)10(log)-20.9(y)62.3(,)-232(R)13.5(us)9.5(s)9.5(i)3.7(a)15.9(n)-228.1(A)29.3(c)6.3(a)6.9(d)3.8(em)24.9(y)-228.8(o)11(f)-229.2(S)-6.1(cien)6.7(c)6.3(e)-0.8(,)-228(R)13.5(us)9.5(s)9.5(i)3.7(a)15.9(n)-229.1(F)31.9(e)5.2(der)18.4(a)22(t)8.6(i)3.7(o)10(n)-0.3(,)]TJ
0 -1.1674 TD
0 Tc
[(A)-229.3(B)15.9(u)14.1(t)8.9(l)4.1(er)18.7(o)13.3(v)-228.5(S)11.3(t)8.9(r)18.7(e)5.5(e)6.5(t)3.9(,)-227.7(M)29.9(o)6.3(s)-3.3(c)6.6(o)13.3(w)-228.3()43.4()-14.9()9.3(,)-229.7(R)13.8(u)-4(s)9.8(s)9.8(i)4(a)]TJ
5.9776 0 0 5.9776 86.688 511.743 Tm
()Tj
8.9664 0 0 8.9664 90.927 507.801 Tm
-0.0097 Tc
[(B)6.2(i)-5.7(ol)-5.6(o)-9.4(g)-15.3(i)-5.7(c)-3.1(al)-239.5(P)9.3(s)-1.9(y)-5.3(c)1.9(hol)-5.6(o)-9.4(g)-30.3(y)52.9(,)-240.4(D)-16.4(ond)-5.6(e)-10.2(r)-6(s)-238.8(C)-13.1(e)-10.2(n)12.4(t)-0.8(r)9(e)-237(for)-238.9(C)-13.1(o)-9.4(g)-15.3(n)7.4(i)4.3(ti)-5.7(on)-9.7(,)-239.4(D)-16.4(ond)-5.6(e)-10.2(r)-6(s)-238.8(I)29.2(n)-9.7(stitute)-238(f)0.3(or)-238.9(B)6.2(r)9(a)6.5(i)3.3(n)-9.7(,)-238.4(C)-13.1(o)-9.4(g)-15.3(n)7.4(iti)-5.7(o)0.6(n)-239.5(a)6.5(nd)-238.4(B)-12.9(e)5.9(ha)13.6(v)-22.4(i)-5.7(or)60.2(,)]TJ
0 -1.1664 TD
-0.0006 Tc
[(Ra)6.6(d)13.6(b)3.6(o)9.7(u)3.4(d)-230.3(U)37.9(n)16.5(i)14.4(vers)9.2(i)13.4(t)-0.7(y)-229.1(N)33.9(i)12.4(j)14.5(m)6.5(e)7.9(gen,)-230.3(P)134.8(.)-0.5(O)26.9(.)-229.3(Bo)17.7(x)-230.2()-0.4( )-10.5(,)-229.3(\012)7.6()-11.4( )-9.4( )-230.3(HE)-229.5(N)33.9(i)12.4(j)14.5(m)6.5(e)7.9(g)-0.2(en,)-230.3()6.6(e)-228.9(N)28.9(e)5.9(t)8.3(h)6.5(e)-1.1(r)7.1(l)3.5(a)15.6(n)6.4(ds)]TJ
/F1 1 Tf
-0.4718 -2.1259 TD
-0.0008 Tc
[(C)-16.3(o)11.3(r)-7.2(r)11.9(esp)-9.8(o)11.3(ndence)-227.2(sho)10.3(u)-5.8(ld)-227.6(b)-9.7(e)-228.2(addr)11.9(ess)-9.2(e)-5.4(d)-227.6(t)5.1(o)-227.5(G)-0.5(.)-228.5(v)-0.5(a)8.6(n)-228.7(L)20.3(u)-0.8(i)11.2(j)9.3(t)5.1(e)3.6(laa)8.6(r)-25.3(;)-228.5(g)-3.6(.va)8.6(n)-5.9(l)11.3(u)-0.8(i)11.2(j)9.3(t)5.1(e)3.6(laa)8.6(r)-1.2(@do)11.3(n)3.2(der)4.8(s)-1.2(.r)-11.2(u)5.2(.)-0.6(n)-5.9(l)]TJ
0 -2.2233 TD
0.001 Tc
[(Recei)8(v)9.3(e)-3.6(d)-227.8()-1.7()-226.1(J)28.9(a)10.4(n)20(ua)10.4(r)-28.5(y)-225.6()-3.7()5.2(;)-226.7(A)27.5(ccep)12.1(t)6.9(e)-3.6(d)-227.8(\012)-226.7(F)20.1(e)4.4(b)13.2(r)-9.4(ua)10.4(r)-28.5(y)-225.6()-3.7()5.2()]TJ
0 -2.1571 TD
-0.0009 Tc
[(A)25.6(c)-3.5(ademic)-229.3(E)-6(d)-0.9(i)11.1(t)5(o)11.2(r)4.7(s:)-227.6(R)-15.3(.)-226.6(L.)-228.6(M)15.8(acdo)11.2(n)2.1(a)-5.6(l)-0.8(d)5.2(,)-228.6(Y)115.2(.)-227.6(W)98.9(a)8.5(n)7.1(g)-32.8(,)-229.6(a)8.5(nd)-228.7(E.)-227.6(M.)-227.6(W)98.9(a)2.5(ss)-9.3(er)-7.3(ma)8.5(nn)]TJ
T*
-0.0012 Tc
[(C)-16.7(o)9.9(p)14.9(y)-3.9(r)-7.6(i)-1.2(g)-8(h)17.9(t)-251.3()-250.7()-5.9()3()-251.8(A.)-227.9(S.)-228.9(B)-10.4(azya)8.2(n)-229.1(a)8.2(n)2.8(d)-229(G)-0.9(.)-227.9(v)-0.9(a)8.2(n)-229.1(L)19.9(u)-1.2(i)10.8(j)8.9(t)4.7(e)3.2(laa)8.2(r)61.7(.)-434.7()-1.2(is)-433.2(is)-433.2(a)8.2(n)-433.9(o)9.9(p)-10.2(en)-433.9(access)-434.2(a)8.2(r)-11.6(t)-6.4(ic)5.3(le)-433.4(dist)-6.4(r)-7.6(i)2.8(b)10(u)10.9(t)4.7(e)-5.8(d)-432.8(u)-1.2(nder)-434.2(t)-7.4(h)2.8(e)-432.4(C)-1.7(r)11.5(e)-6.8(a)18.2(t)-6.4(i)5.8(v)7.1(e)-433.4(C)-16.7(o)10.9(m)-1.2(mo)10.9(n)6.8(s)]TJ
0 -1.1664 TD
-0.001 Tc
[(A)40.6(t)8.9(t)-6.2(r)-7.4(ib)10.2(u)11.1(t)-6.2(io)11.1(n)-227.9(L)-7(icen)7(s)-9.4(e)-0.6(,)-227.7(w)-7.6(hic)5.5(h)-228.8(p)-10(er)-7.4(mi)11(ts)-227.2(unr)11.7(est)-6.2(r)-7.4(ic)-7.6(t)4.9(e)-5.6(d)-227.8(u)2(s)-9.4(e)5.4(,)-227.7(d)-1(ist)-6.2(r)-7.4(ib)10.2(u)11.1(t)-6.2(io)]TJ
25.262 0 TD
-0.0001 Tc
[(n,)-226.8(a)9.3(n)3.9(d)-226.9(r)12.6(ep)12(r)12.6(o)-9(d)12(u)-0.1(c)-6.7(t)-5.3(io)12(n)-227(i)-0.1(n)-227(a)9.3(n)23(y)-226.7(medi)12(um,)-225.8(p)12(r)12.6(o)16.1(vided)-227.9(t)-6.3(he)-226.5(o)12(r)-6.5(iginal)-226.9(w)8.4(o)12(rk)-226.8(is)]TJ
-25.262 -1.1664 TD
-0.0005 Tc
[(p)11.6(r)12.2(o)10.6(p)-9.5(erl)6.6(y)-227.1(ci)11.5(t)5.4(e)-5.1(d.)]TJ
0 -2.3006 TD
-0.0007 Tc
[(e)-277.3(a)7.7(b)-0.6(s)-9.1(e)-0.3(nce)-277.3(e)-0.3(p)11.4(i)-5.7(lepsy)-278.4(t)-3.8(yp)11.4(ica)-5.4(l)-277.7(elec)-7.3(t)-5.9(r)12(o)-9.6(e)-0.3(ncep)6.4(ha)-5.4(log)-5.5(ra)18.7(p)6.4(hic)-280.3(p)-5.7(a)18.7(t)9.2(t)5.2(er)-7.1(n)-277.8(o)11.4(f)-276.8(s)3(ha)8.7(r)-11.1(p)-276.7(sp)11.4(i)-5.7(k)8.5(es)-278.1(a)8.7(n)3.3(d)-276.7(s)2.9(lo)15.5(w)-277.3(w)-0.2(a)17.7(v)7.6(es)-279.1(\(SWD)5.6(s\))-277(is)-277.1(co)11.4(n)7.3(s)-1.1(ider)12(e)-5.3(d)-277.7(t)5.2(o)-277.6(b)-9.6(e)-277.3(d)11.4(ue)-277.3(t)5.2(o)]TJ
0 -1.1664 TD
-0.0001 Tc
[(a)9.3(n)-335.4(in)18.9(t)5.8(e)0.3(rac)-6.7(t)-5.3(io)12(n)-336.4(o)12(f)-335.5(a)9.3(n)-335.4(ini)11.9(t)-5.3(i)-3.1(a)19.3(t)-5.3(io)12(n)-335.4(s)-0.5(i)11.9(t)5.8(e)-334.9(i)-0.1(n)-335.4(t)-6.3(he)-335.9(co)12(r)-10.5(t)5.8(ex)-335.1(a)9.3(n)3.9(d)-336.3(a)-335(r)12.6(e)0.3(s)-8.5(o)12(na)9.3(n)18.9(t)-335.5(cir)12.6(c)-6.7(ui)12(t)-336.5(i)-0.1(n)-335.4(t)-6.3(he)-334.9(t)-6.3(h)2.9(ala)9.3(m)18.9(us.)-336.2()3.9(e)-335.9(h)23(yp)-9.1(er)-10.5(p)-9.1(o)7(la)9.3(r)-6.5(i)-0.1(za)19.3(t)-5.2(i)-0.1(o)12(n)-0.1(-ac)-6.7(t)-5.3(i)6.9(v)0.2(a)19.3(t)5.8(ed)-337.3(c)-15.7(y)8.2(c)6.4(l)0(ic)]TJ
T*
0.0017 Tc
[(n)20.7(u)1.7(c)8.2(l)1.8(eo)12.8(t)-3.5(ide-ga)21.1(t)7.6(ed)-342.5(ca)21.1(t)-3.5(i)1.7(o)13.8(nic)]TJ
/F2 1 Tf
10.5342 0 TD
0 Tc
(I)Tj
/F4 1 Tf
5.9776 0 0 5.9776 184.563 355.053 Tm
(h)Tj
/F1 1 Tf
8.9664 0 0 8.9664 191.376 357.204 Tm
-0.0004 Tc
[(p)-5.4(acema)-5.1(k)8.8(er)-345.1(c)6.1(h)2.6(a)9(n)-0.4(nels)-344(\(H)11.8(CN\))-343(p)6.7(la)18(y)-342.4(a)9(n)-343.7(i)-0.4(m)18.6(p)-9.4(o)11.7(r)-10.8(t)-6.6(a)9(n)18.6(t)-342.8(r)12.3(o)6.7(le)-342.3(in)-342.7(t)-6.6(h)3.6(e)-343.3(e)0(n)-5.5(h)2.6(a)9(n)3.6(ced)-343.7(c)0(o)11.8(r)-10.8(t)-5.6(i)-0.4(ca)-5.1(l)-343.6(e)0(x)7.9(c)0(i)11.7(t)-6.6(a)8(b)11.8(i)-5.4(l)-0.3(i)11.7(t)-3.6(y)73.2(.)-345.5(e)-342.3(r)12.3(o)6.7(le)]TJ
-11.6746 -1.1664 TD
-0.0007 Tc
[(o)11.4(f)-295.9(t)-6.9(h)2.3(a)-5.4(l)-3.7(a)8.7(mic)-295.4(H)11.5(C)-1.2(N)-295.6(i)-0.7(n)-295.8(S)-0.5(WD)-295.5(o)-9.6(c)-0.3(c)-7.3(u)-0.7(r)-7.1(r)12(ence)-297.4(is)-295.2(less)-296.2(c)5.8(l)-0.6(e)-6.3(a)8.7(r)62.2(.)-296.7(A)29.8(b)-0.6(s)-9.1(e)-0.3(nce)-296.4(e)-0.3(p)11.4(i)-5.7(lepsy)-296.5(i)-0.7(n)-295.8(t)-6.9(he)-295.4(W)123.2(A)27.8(G/Ri)11.4(j)-296.8(s)4(t)-5.9(r)-1.1(a)8.7(i)-0.7(n)-294.8(i)2.3(s)-296.2(acco)11.4(m)18.3(p)-5.7(a)8.7(nied)-297.8(b)15.5(y)-295.5(d)-0.7(ecienc)-16.3(y)-297.5(o)11.4(f)-294.9(t)-6.9(h)3.3(e)]TJ
0 -1.1674 TD
0.0002 Tc
[(ac)-6.4(t)-5(i)7.2(vi)12.2(ty)-283.6(o)12.4(f)-283(do)11.3(pa)9.6(miner)7.9(gic)-284.4(s)-0.2(yst)6.1(e)0.6(m,)-282.7(w)-6.4(hic)6.7(h)-283.8(w)8.7(e)-5.4(a)-4.5(k)9.4(e)0.6(n)8.2(s)-285.2(t)-6(h)4.2(e)-283.4(f)9.1(o)12.4(r)-6.2(ma)19.6(t)-5(i)0.2(o)12.3(n)-282.9(o)12.3(f)-283(a)9.6(n)-283.9(emo)11.3(t)-4.9(io)12.3(nal)-283.8(p)-8.8(osi)12.3(t)-5(i)7.2(v)8.5(e)-283.4(s)4.9(t)-6(a)19.6(t)6.1(e)6.6(,)-283.7(c)-2.4(a)19.6(u)3.2(s)-8.2(e)0.6(s)-283.2(d)0.2(ep)12.3(r)12.9(e)0.6(ssio)12.3(n-lik)9.4(e)-283.4(sym)19.2(p)11.3(t)6.1(o)12.3(m)8.2(s)-0.2(,)]TJ
0 -1.1664 TD
-0.0012 Tc
[(a)8.2(n)2.8(d)-277.2(c)-0.8(o)9.9(u)-1.2(n)17.8(t)4.7(erac)-7.8(ts)-278.6(le)-6.8(a)8.2(r)-7.6(nin)6.8(g)-278(a)8.2(nd)-277.2(memo)10.9(r)-30.7(y)-276.9(p)10.9(r)11.5(o)-10.1(cess)-9.6(e)-0.8(s.)-278.1(I)37.7(t)-276.4(a)-5.9(l)1.9(s)-9.6(o)-278.1(en)-6.3(ha)8.2(nces)-278.6(GAB)22.7(A)]TJ
/F4 1 Tf
5.9776 0 0 5.9776 349.992 323.67 Tm
0 Tc
(A)Tj
/F1 1 Tf
8.9664 0 0 8.9664 357.174 325.821 Tm
-0.0009 Tc
[(r)11.8(e)-5.5(cep)10.2(t)5(o)11.2(r)-278.3(a)-0.5(c)-7.5(t)-6(i)6.1(v)-3.6(i)11.1(t)-4(y)-277.6(i)-0.9(n)-277(t)-7.1(he)-276.5(st)-6.1(r)-7.3(i)-3.9(a)18.5(t)9(um,)-276.8(g)-7.7(l)-0.8(o)4.2(b)10.3(us)-277.3(pallid)11.2(us,)-276.8(a)8.5(nd)]TJ
-30.1657 -1.1664 TD
0.0002 Tc
[(r)12.9(e)0.6(t)-5(i)0.2(c)-6.4(u)-4.8(la)9.6(r)-311.3(t)-6(hala)9.6(mic)-311.5(n)19.2(u)0.2(c)6.7(l)0.3(eus,)-310.8(ca)19.6(usin)8.2(g)-311.7(a)-310.6(r)-6.2(i)3.2(s)-8.2(e)-309.5(o)12.3(f)-311.1(SWD)-310.7(a)0.6(c)-6.4(t)-5(i)7.2(v)-2.5(i)12.3(t)-2.9(y)-311.7(i)0.2(n)-311(t)-6(he)-310.5(co)12.3(r)-10.2(t)-4.9(ico-t)-6(h)3.2(ala)9.6(m)4.2(o-co)12.3(r)-10.2(t)-4.9(ical)-311.9(netw)8.7(o)12.3(r)3.8(ks.)-310.8(O)0.4(ne)-311.5(o)12.3(f)-311.1(t)-6(h)4.2(e)-310.5(r)12.9(e)-5.4(a)3.6(s)-8.2(o)12.3(n)8.2(s)-310.3(f)9.1(o)12.3(r)-310.3(t)-6(he)]TJ
0 -1.1674 TD
-0.001 Tc
[(o)-9.9(c)-0.6(c)-7.6(u)-1(r)-7.4(r)11.7(ence)-309.7(o)11.1(f)-308.2(a)7.4(b)-0.9(s)-9.4(e)-0.6(nces)-310.5(is)-308.5(t)-7.2(h)2(a)18.4(t)-308.3(s)-9.4(e)-8.6(v)7.3(e)-0.6(ra)-5.7(l)-309.1(g)7.3(enes)-310.5(co)-9.9(din)7(g)-308.9(o)11.2(f)-308.2(G)-0.7(AB)22.9(A)]TJ
/F4 1 Tf
5.9776 0 0 5.9776 309.843 302.7451 Tm
0 Tc
(A)Tj
/F1 1 Tf
8.9664 0 0 8.9664 317.313 304.8961 Tm
0.3077 Tc
[(r)320.4(e)303.1(c)308.1(e)308.1(p)318.8(t)313.6(o)319.8(r)313.3(s)-0.8(a)317.1(r)320.4(em)326.7(u)319.8(t)301.5(a)327.1(t)313.6(e)303.1(d)313.8(.)311.7(eq)317.8(u)307.7(e)308.1(s)312.4(t)302.6(i)307.7(o)319.8(na)317.1(r)301.3(i)310.7(s)299.3(e)308.1(s)307.3(:)-0.3(w)301.1(h)310.7(a)327.1(t)-0.6(t)301.5(h)311.7(er)320.4(o)314.8(l)307.8(eo)319.8(fD)344.1(A)]TJ
-25.7201 -1.1664 TD
-0.0012 Tc
[(r)11.5(e)-5.8(cep)9.9(t)4.7(o)10.9(r)4.4(s)-260.5(is.)-260(T)71.8(w)7.3(o)-261.1(mec)5.2(h)1.8(a)8.2(n)-1.2(ism)6.8(s)-261.5(t)-7.4(h)1.8(a)18.2(t)-260.3(ca)18.2(us)-9.6(e)-260.8(a)8.2(n)-261.2(inf)-11.3(r)-7.6(i)-1.2(n)6.8(g)7.1(emen)17.8(t)-260.3(o)10.9(f)-261.3(t)-7.4(he)-259.7(f)-7.3(u)-1.2(nc)-7.8(t)-6.3(i)-1.2(o)10.9(n)-260.2(o)10.9(f)-261.3(D)35.2(A)-260.7(r)11.5(e)-5.8(cep)9.9(t)4.7(o)10.9(r)4.4(s)-260.5(in)-260.2(t)-7.4(h)-1.2(is)-260.5(g)7.1(e)-0.8(net)-6.3(i)-1.2(c)-261.7(a)7.2(bs)-9.6(ence)-260.8(ep)10.9(i)-6.2(l)-1.1(epsy)-260.9(mo)-10.1(del)]TJ
T*
-0.0097 Tc
[(are)-236.1(p)2.4(rop)-18.7(o)-9.6(s)-18.1(e)-14.3(d.)]TJ
/F3 1 Tf
11.9551 0 0 11.9551 50.58 244.641 Tm
0 Tc
[(1.)-250.3(Introduction)]TJ
/F1 1 Tf
9.9626 0 0 9.9626 50.58 222.2581 Tm
0.0002 Tc
[(A)29.9(b)0.5(s)-7.7(e)0.6(nce)-422.2(s)-7.7(eizur)12.6(e)0.6(s,)-422.2(typ)12(i)-0.1(ca)-5.3(l)-422.5(f)8.9(o)11.5(r)-421.1(ma)9.2(n)22.3(y)-420.7(di\015)9.2(e)0.6(r)12.6(e)0.6(n)18.7(t)-422.9(p)-5.2(a)19.1(t)-5.6(i)-0.1(en)18.7(ts)-419.6(wi)11.6(t)-6.5(h)]TJ
0 -1.141 TD
-0.0003 Tc
[(a)7.8(b)0(s)-8.2(e)0.1(nce)-257.4(e)0.1(p)11.5(i)-6(lepsy)73(,)-256.5(p)11.5(r)-6.9(inci)11.1(p)-5.7(a)-5.8(l)-5.7(l)7(y)-254.1(d)0.1(i\015)8.7(er)-257.1(f)-10.6(r)12.1(o)11(m)-254.5(co)11(n)21.8(v)-0.7(u)-5.9(l)2.5(si)6.6(v)7.4(e)-253.7(s)-8.2(e)0.1(izur)12.1(es.)]TJ
T*
[(T)97.1(o)-271.8(i)-6.1(l)-5.8(l)11.4(u)2.1(s)5.2(t)-6.2(ra)18.5(t)5.6(e)6.3(,)-270.2(a)-272.4(n)18.1(u)-0.6(m)9.2(b)-9.1(er)-270.8(o)10.9(f)-271.7(widel)6.9(y)-273.1(us)-8.3(e)-5.4(d)-271(a)8.6(n)2.8(d)-271.9(e)0(cien)18.1(t)-271.8(a)8.6(n)18.1(t)-6.2(i)-0.7(co)10.9(n-)]TJ
T*
-0.0008 Tc
[(vu)-6.4(ls)-6.9(a)8.2(n)17.7(t)-194.5(d)-0.4(r)-11(u)-1(gs)-197.5(en)-6.7(ha)8.2(nce)-195.5(a)7.3(bs)-8.7(ence)-196.4(s)-8.7(e)-0.4(izur)11.6(es)-196.6(in)-196.4(p)-6.2(a)18.1(t)-6.6(i)-1.1(en)17.7(ts)-194.8(a)8.2(n)2.4(d)-195.5(i)-1.1(n)-196.4(t)-7.5(he)]TJ
0 -1.2205 TD
-0.002 Tc
[(genet)-7.8(i)-2.3(c)-371.3(a)6.1(bs)-9.9(ence)-372.9(mo)-11.4(dels)-370.4(a)7(n)1.2(d)-372(e)-1.6(t)-8.7(h)1.7(osuximide)-371.1(i)0.4(s)-372.2(o)9.3(n)-7.9(l)5.3(y)-370.5(e)-1.6(\015)7(e)-7(c)-9(t)-7.8(ive)]TJ
0 -1.2214 TD
-0.0007 Tc
[(in)-392.3(s)4.9(u)10.9(p)10.2(p)11.1(r)11.7(e)-0.3(s)4.9(s)-0.5(in)7(g)-392.7(a)7.4(bs)-8.6(ence)-393.3(s)-8.6(e)-0.3(izur)11.7(es)-392.5(a)8.3(n)2.5(d)-391.4(c)-0.5(o)10.6(m)17.9(p)6.6(l)-0.6(et)5.3(el)6.6(y)-392.7(i)-1(ne\015)8.3(e)-5.7(c)-7.7(t)-6.5(i)6.2(v)7(e)]TJ
0 -1.141 TD
-0.0003 Tc
[(in)-296.2(o)10.1(t)-7(her)-296(t)-3.4(yp)-9.3(es)-297.3(o)11(f)-296(s)-8.2(e)0.1(izur)12.1(es)-296.4([)]TJ
0 g
10.8333 0 TD
0 Tc
()Tj
0 0 0 1 k
0.3379 0 TD
()Tj
0 g
0.5203 0 TD
()Tj
0 0 0 1 k
0.4517 0 TD
-0.0007 Tc
[(].)-297.6(A)29(b)-0.4(s)-8.6(e)-0.3(nce)-297.5(e)-0.3(p)11.1(i)-6.4(lepsy)-297.8(i)1.7(s)-295.9(c)5.8(ha)8.3(rac-)]TJ
-12.1432 -1.141 TD
0.0069 Tc
[(t)12.9(e)7.3(ri)6.6(z)6.8(e)1.9(d)-351.3(b)23.5(y)-352.6(t)0.2(h)10.6(e)-351.3(oc)7.1(cu)6.7(rr)19.3(e)7.3(n)10.1(c)7.1(e)-349.5(o)18.2(f)-352.1(s)12.5(p)-2.1(o)18.2(n)25.4(ta)15.9(n)10.1(e)1.9(o)17.3(u)9.4(s)-348.8(o)-2.5(c)7.1(c)-0.1(u)6.7(rri)6.6(n)14.6(g)-349(s)12.5(p)18.7(ik)16(e)7.3(-)]TJ
T*
-0.0008 Tc
[(wa)17.2(v)6.9(e)-228(dis)-8.7(c)5.7(ha)8.2(r)7(g)7.4(es)-228.2(\(SWD)5.2(s\))-227.5(a)8.2(n)2.4(d)-227.1(p)-9.8(er)-7.4(io)-10.2(ds)-227.3(o)10.5(f)-227(r)11.6(e)-5.8(d)11.4(u)-1(ce)-5.8(d)-227.1(a)-6.3(ler)-11(t)-6.6(nes)4.8(s)-227.3(o)10.5(r)]TJ
T*
-0.0055 Tc
[(r)6.9(e)-5.1(sp)-14.5(o)5.8(n)2.2(s)-5.3(i)1.4(ve)-5.1(ne)-5.1(ss)-5.3(.)-235.5()-2.3(e)-233.6(S)-5.8(W)-5.6(D)0.5(s)-234.7(a)3.5(r)6.9(e)-234.6(i)-5.8(n)-2.3(d)6.7(u)-5.7(c)-5.3(e)-10.5(d)-233.6(b)11.1(y)-235.8(h)17.2(y)-5.4(p)-14.5(e)-5.1(r)-15.7(p)-14.5(o)1.3(l)-8.2(a)3.5(r)-12.1(i)-5.8(z)-5.6(a)13.4(t)-11.3(i)-5.8(o)5.8(n)]TJ
T*
0.2869 Tc
[(a)295.9(n)290.1(dt)280.2(h)290.6(e)279.2(ya)305.8(p)297.8(p)277.9(e)281(a)295.9(ro)298.2(na)295.9(no)297.3(t)280.2(h)290.6(e)287.3(r)257.7(w)284.4(i)289.3(s)279(e)0.9(n)290.1(o)298.2(r)280.3(m)289.2(a)281.4(l)2.4(E)286.7(E)286.7(G)287.3(.)290.1(es)292.5(p)298.7(i)281.2(k)296(e)0(o)298.2(f)]TJ
T*
-0.0002 Tc
[(t)-6.9(h)3.5(e)-222.9(S)-0.5(WD)-222.8(r)12.2(e)0.2(p)11.6(r)12.2(es)-8.1(en)18.3(ts)-223.1(a)8.8(n)-223.8(ex)8.4(ci)11.2(t)-6.9(a)18.7(t)5.8(o)11.1(r)-29.4(y)-222.3(p)-9.2(o)-0.6(s)5.4(t)-0.5(syna)18.7(p)10.7(t)-6(ic)-222.2(p)-9.2(o)10.2(t)5.8(e)0.2(n)18.3(t)-6(ia)-5.7(l)-221.5(a)8.8(nd)]TJ
T*
-0.0112 Tc
[(bu)-11.4(r)-5.2(s)-5.6(t)-11.5(s)-398.5(of)-397.3(a)-11.2(c)-18.2(t)-17(i)-11.5(on)-396.5(p)-20.2(o)-0.8(t)-5.2(e)-10.8(n)7.3(t)-17(i)-14.2(a)-16.7(l)-8.4(s)-396.7(\()]TJ
0 g
11.5334 0 TD
0 Tc
[(Figur)12.4(e)-225.4(\(b\))]TJ
0 0 0 1 k
4.3434 0 TD
0.3868 Tc
[(\)o)398.1(ft)380.1(h)389.6(a)381.3(l)384.1(a)395.8(m)390(o)377.4(c)387(o)398.1(r)376.6(t)381(i)386.5(c)384.3(a)381.3(l)]TJ
-15.8768 -1.141 TD
-0.0005 Tc
[(a)8.5(n)2.7(d)-272.9(c)-0.3(o)10.8(r)-10.7(t)-6.3(i)-0.8(co)9.9(t)-7.2(h)2.3(a)-6(l)-3.2(a)8.5(m)-0.9(ic)-270.4(cel)-5.9(l)2.3(s,)-274.8(t)-7.2(h)3.2(e)-272.9(w)-0.3(a)17.5(v)7.2(e)-273.8(a)-274.3(slo)15.3(w)-274(wa)17.5(v)7.2(e)-273.8(in)-273.8(t)-7.2(h)3.2(e)-272.9(EEG,)]TJ
T*
0.0067 Tc
[(i)9.1(s)-397.8(th)10.4(e)-398.5(s)12.3(u)10.1(b)7(seq)16.3(u)6.5(e)7.1(n)25.2(t)-398.4(i)6.4(nh)6.8(i)10(b)18.7(i)18.1(t)12.7(o)18(r)-22.5(y)-395.2(p)14(h)9.5(a)9.4(se)-398.5([)]TJ
0 g
15.0719 0 TD
0 Tc
( )Tj
0 0 0 1 k
0.4969 0 TD
(,)Tj
0 g
0.6333 0 TD
()Tj
0 0 0 1 k
0.4544 0 TD
-0.0012 Tc
[(].)-407.4(e)-405.5(genera)-6.7(lize)-6.2(d)]TJ
-16.6564 -1.1419 TD
-0.0004 Tc
[(a)8.6(n)2.8(d)-249.3(w)-2.9(ides)5.2(p)11.4(r)12(e)-6.3(a)-0.4(d)-252(b)11.6(i)-6.1(l)-3.1(a)18.5(t)5.6(era)-5.9(l)-5.8(l)6.9(y)-248.7(sync)6.1(hr)12(o)10.9(n)2.8(o)10(u)2.1(s)-247.7(S)-0.7(WD)5.6(s)-250.4(a)8.6(r)12(e)-249.3(t)-7.1(h)3.3(e)-250.2(r)12(es)5.2(u)-6(l)11.4(t)]TJ
25.8998 19.5219 TD
0 Tc
[(o)11.3(f)-473.7(hig)-7.2(h)-5.3(l)7.3(y)-473.3(sync)6.5(hr)12.4(o)11.3(n)-0.5(ized)-472(os)-7.9(ci)-5.7(l)-5.4(l)-2.7(a)18.9(t)-5.8(io)11.3(n)7.7(s)-470.4(in)-473.8(co)11.3(r)-10.2(t)-5.8(ico)10.4(t)-6.7(ha)-5.5(la)9(mo)-9.5(co)11.3(r)24.1(-)]TJ
0 -1.141 TD
0.0002 Tc
[(t)-5.6(i)-0.1(ca)-5.3(l)-441.5(n)3.4(etw)8.6(o)11.5(rks.)-443(SWD)6.2(s)0.4(,)-442.1(a)2.9(s)-442.2(c)-2.3(a)9.2(n)-442.9(b)-8.5(e)-442.9(f)8.9(o)10.6(und)-440.2(i)-0.1(n)-442(W)122.9(A)28.1(G/Ri)11.6(j)-443(ra)19.1(ts,)]TJ
T*
-0.0004 Tc
[(ha)17.6(v)7.3(e)-462.5(a)-462.1(l)-0.4(o)-9.8(c)-2.9(a)-5.9(l)-462(co)10.9(r)-10.6(t)-6.2(ica)-5.9(l)-461.1(o)10.9(r)-7(ig)-5.8(in)-460.7(in)-461.6(t)-7.1(h)3.3(e)-461.6(p)-9.4(er)-7(io)10.9(ra)-5.9(l)-461.1(r)12(eg)-5.8(io)10.9(n)-460.7(o)10.9(f)-462.3(t)-7.1(he)]TJ
T*
0.0079 Tc
[(so)19.2(m)10.2(a)26.8(t)13.9(o)7.5(se)8.3(n)15.6(s)0(o)19.2(r)-21.3(y)-433.8(c)8.1(o)19.2(r)-2.3(t)13.9(e)8.3(x)-436.1([)]TJ
0 g
9.7203 0 TD
0 Tc
(\012)Tj
0 0 0 1 k
0.4951 0 TD
()Tj
0 g
0.5203 0 TD
0.0026 Tc
()Tj
0 0 0 1 k
0.8049 0 TD
0.0009 Tc
[(],)-443.2(w)-6.1(h)1(ic)7.4(h)-443.5(i)3.3(s)-442.4(n)4.1(o)16.7(w)-441.5(co)12.2(nr)-5.7(m)4.1(ed)-441.3(in)]TJ
-11.5406 -1.141 TD
-0.0001 Tc
[(GAERS)-247.9([)]TJ
0 g
3.6614 0 TD
()Tj
0 0 0 1 k
0.7905 0 TD
0 Tc
(,)Tj
0 g
0.4752 0 TD
-0.0164 Tc
( )Tj
0 0 0 1 k
0.8194 0 TD
-0.008 Tc
[(])-8.1(,)-255.2(an)-4.8(ot)-14.7(h)-4.3(e)-7.6(r)-253.1(w)0.4(el)-13.4(l)-255.5(v)-8.4(a)-13.5(l)-7.9(i)-8.3(d)-10.3(a)10.9(t)-2(e)-13(d)-255.1(an)-4.8(d)-254.2(o)3.3(e)-7.6(n)-255.1(u)-5.5(s)-15.9(e)-13(d)-255.1(s)-2.4(t)-13.8(r)-8.3(ai)-8.3(n)]TJ
-5.7464 -1.141 TD
0.0002 Tc
[(o)11.5(f)-274.7(ra)19.1(ts)-274.2(wi)11.6(t)-6.5(h)-274.3(a)8.3(b)0.5(s)-7.7(e)0.6(nce)-274.9(e)0.6(p)12(i)-5.5(lepsy)-275.2([)]TJ
0 g
12.135 0 TD
-0.0001 Tc
()Tj
0 0 0 1 k
0.7914 0 TD
0 Tc
(,)Tj
0 g
0.5032 0 TD
-0.0056 Tc
(\012)Tj
0 0 0 1 k
0.8284 0 TD
0.001 Tc
[(].)-274.2(L)-8.5(o)-8.4(ca)-4.5(l)-272.7(i)0.7(n)19.5(j)-4.1(ec)-6(t)-4.8(i)0.7(o)12.3(n)8.7(s)-271.6(i)0.7(n)-274.1(t)-5.7(he)]TJ
-14.258 -1.141 TD
-0.0115 Tc
[(p)-20.5(e)-11.1(r)-18.1(i)-11.8(or)-11.8(a)-17(l)-399(re)-11.1(g)-16.9(i)-11.8(on)-399.5(of)-399.4(t)-18.2(h)-7.8(e)-399.5(s)-19.4(om)-9.2(a)7.4(t)-5.5(o)-11.9(s)-19.4(e)-11.1(n)-3.8(s)-19.4(o)-0.2(r)-40.7(y)-399(c)-11.3(o)-0.2(r)-21.7(t)-5.5(e)-11.1(x)-400.4(of)-399.4(t)-18.2(h)-7.8(e)-399.5(T)44.5(-)-11.4(t)-14.6(y)-11.4(p)-20.5(e)]TJ
0 -1.2412 TD
0.0089 Tc
(Ca)Tj
/F5 1 Tf
6.9738 0 0 6.9738 319.698 168.456 Tm
-0.0005 Tc
(2+)Tj
/F1 1 Tf
9.9626 0 0 9.9626 331.533 164.0731 Tm
-0.001 Tc
[(c)5.5(h)1.8(a)8(n)-1.5(nel)-369.5(b)6.5(lo)-10.4(c)5.5(k)8.1(er)-371.7(et)-7.7(hos)4.6(u)-1.2(ximide)-370.1(was)-370.3(r)-1.3(a)17.9(t)-7.7(her)-369(e)-0.6(\015)8(e)-6(c)-8(t)-6.8(i)5.9(v)6.7(e)-370.1(i)-1.3(n)]TJ
-2.3009 -1.141 TD
-0.0056 Tc
[(su)6(p)5.3(p)6.2(r)6.8(e)-5.2(ss)-5.4(i)-5.9(n)2.1(g)-434.7(S)-5.9(W)-5.7(D)0.4(s)-433.6([)]TJ
0 g
8.4366 0 TD
-0.0065 Tc
()Tj
0 0 0 1 k
0.7959 0 TD
-0.0009 Tc
[(],)-429.7(b)10.2(u)10.7(t)-429.4(a)-6.4(ls)-8.8(o)-429.5(i)-1.2(n)-428.6(L)-10.3(o)10.4(n)6.8(g-E)18.7(v)-1.3(a)8.1(n)6.8(s)-428(r)-1.2(a)18(t)-1.2(s)-428.9(w)-3.4(i)10.5(t)-7.6(h)]TJ
-9.2325 -1.141 TD
-0.0002 Tc
[(SWD)5.8(s)0(,)-192.3(a)8.8(nd)-191.3(in)-192.2(W)37.6(i)2.2(s)5.4(t)-6.9(a)8.8(r)-191.1(ra)18.7(ts)-191.5(t)-6(r)12.2(e)-6.1(a)18.7(t)5.8(e)-5.2(d)-190.4(w)-2.7(i)11.2(t)-6.9(h)-191.6(a)-191.8(lo)15.6(w)-192.4(d)0.2(os)-8.1(e)-192.2(o)11.1(f)-191.1(P)0(TZ)-192.2([)]TJ
0 g
22.719 0 TD
-0.0056 Tc
()Tj
0 0 0 1 k
0.8085 0 TD
0.0001 Tc
(].)Tj
-23.5275 -1.141 TD
0.0075 Tc
[()10.7(e)-163.7(c)7.7(o)18.8(rt)13.5(e)7.9(x)-164.6(i)9.9(s)-163.9(pa)16.5(rt)-164.5(o)18.8(f)-164.5(a)-164.2(n)10.7(e)7.9(t)4.4(w)15.9(o)18.8(r)10.8(k)-163.2(i)7.2(n)-164.6(wh)7.6(i)7.2(c)14(h)-164.9(t)0.8(h)11.2(e)-163.7(r)19.9(e)7.9(ti)7.2(cul)4.8(a)16.5(r)-163.5(t)0.8(h)10.3(a)2(l)4.8(a)16.5(m)7.1(i)7.2(c)]TJ
T*
-0.0008 Tc
[(n)17.7(u)-1(c)5.7(l)-0.7(eus)-327.6(\()-0.8(R)31.2(T)-0.8(N\))-326.9(is)-326.7(a)8.2(n)-327.4(es)4.8(s)-8.7(e)-0.4(n)17.7(t)-6.6(ia)-6.3(l)-326.9(p)-6.2(a)8.2(r)-11(t.)-326.6(e)-326.5(R)31.2(T)-0.8(N)-326.5(i)1.6(s)-326.7(r)11.6(es)4.8(p)-9.8(o)10.5(n)6.9(s)-0.6(ib)6.7(le)]TJ
T*
0.0001 Tc
[(f)8.8(o)11.4(r)-310.1(t)-6.6(he)-310.3(ini)11.5(t)-5.7(ia)19(t)-5.7(i)-0.2(o)11.4(n)-307.5(o)11.4(f)-310.1(sleep)-311.5(s)5.7(p)11.9(i)-0.2(ndles)-311.3(n)3.3(o)10.5(t)-309.2(o)11.4(n)-5.8(l)7.4(y)-309.7(in)-311.1(ra)19(ts,)-310.3(b)11.2(u)11.7(t)-311(a)-5.4(l)2.9(s)-7.8(o)]TJ
T*
-0.0005 Tc
[(in)-348.7(o)9.9(t)-7.2(her)-347.7(s)5.1(p)-9.5(e)-5.5(cies)-349([)]TJ
0 g
7.1484 0 TD
-0.0101 Tc
()Tj
0 0 0 1 k
0.8167 0 TD
0 Tc
(,)Tj
0 g
0.5754 0 TD
0.0057 Tc
()Tj
0 0 0 1 k
0.963 0 TD
0.0044 Tc
[(].)-344.9(I)43.7(t)-343.7(n)7.6(eed)7.5(s)-343.2(t)10.4(o)-343.8(b)-4.3(e)-343.9(a)4.4(c)10.9(k)0.8(n)7.6(o)20.2(wl)4.5(ed)4.8(g)12.6(e)-0.6(d)-343.9(t)-2.3(h)7.2(a)23.3(t)]TJ
-9.5035 -1.1419 TD
-0.0009 Tc
[(p)10.9(r)11.5(e)-8.6(v)-4(io)9.5(usl)6.4(y)-413.7(t)-7.6(h)2.8(e)-415.1(R)31.1(TN)-415.1(was)-415.3(c)-0.7(o)10.4(n)6.8(sider)11.5(e)-5.9(d)-415.1(as)-415.3(t)-7.6(h)2.8(e)-414.2(p)-6.3(acema)-6.4(k)8.2(er)-414.9(f)7.8(o)10.4(r)]TJ
0 -1.141 TD
-0.0013 Tc
[(SWD)4.7(s)-270.3(as)-270.3(w)7.1(e)2.7(l)-6.7(l)-271.4([)]TJ
0 g
6.1068 0 TD
0.003 Tc
()Tj
0 0 0 1 k
0.8058 0 TD
0 Tc
(,)Tj
0 g
0.4969 0 TD
0.0057 Tc
()Tj
0 0 0 1 k
0.935 0 TD
0.0003 Tc
[(].)-269.5(N)26(o)16.1(wada)18.3(ys)-270.5(t)-6.4(h)4(e)-268.5(o)11.6(r)-6.3(i)0(g)-5.1(i)0(n)-266.6(o)11.6(f)-268.3(t)-6.4(he)-268.5(ini)11.7(t)-5.5(ia)19.2(t)-5.5(i)0(o)11.6(n)]TJ
-8.3445 -1.141 TD
-0.0106 Tc
[(s)-10.4(i)0.8(t)-4.6(e)-381.5(of)-380.4(S)-10.9(W)-10.7(D)-4.6(s)-379.9(i)-8.2(s)-380.8(t)-17.3(h)-6.9(e)-380.6(s)-5(u)-7.2(b)0.5(j)-15.7(e)-15.6(c)-17.6(t)-381.3(of)-380.4(qu)-10.8(it)-4.6(e)-379.7(s)-18.5(om)-7.4(e)-379.7(r)1.8(e)-10.2(s)-18.5(e)-16.5(a)-1.6(rch)-380.9(e)-10.2(\015or)-20.8(t)-10.9(s)-10.4(,)]TJ
T*
-0.0011 Tc
[(in)-355.7(ra)17.8(ts)-355.9(as)-355(w)7.3(e)2.9(l)-6.5(l)-356.1(as)-355.9(in)-355.7(h)18(u)-1.3(ma)7.9(n)6.6(s)-355(a)7.9(n)2.1(d)-355.7(i)10.3(t)-355.6(i)1.3(s)-355(w)-3.6(idel)6.2(y)-357(a)1.6(s)4.5(s)4.5(u)-1.3(med)-355.7(t)-7.8(ha)17.8(t)]TJ
ET
Q
endstream
endobj
3 0 obj
<>stream
q
1 0 0 -1 0 792 cm -100 Tz
q
q 1 0 0 -1 500.05 100 cm 100 Tz /Fm0 Do Q
Q
Q
endstream
endobj
5 0 obj
<>
endobj
7 0 obj
<>
endobj
9 0 obj
<>stream
HdSTQ3J3QID\+AUqI " 5 D**l[Ֆ+7tsz̝7w@. *]ΐa4$F6`g!nz
Icscٺq=$ȋ#>dFMG~( C֢xh*@aTrTjD0śt[ghuffIIZYrJljR4)l135'I,RӬM4j>p.!<̣UZN7t'Hnub !پC8s74LYl/K7S
F5p|^/7:$7jLcsqQ
N4C|C̙'_1 $x
n0&""(EH!B.(!+B*$9D@靱F
≋eKKK}x<-o/vC Aah(_$#Ft0Q5nF.bӘQcΎ[:u{) 4dǺ6nBD=' )(^iw:.?1\ _+o$r7?o}3лu.B)p(Y`dUYʩ*1tX3QsX-
ɍ.W'%=쫁ՓT5|7휙O6RlRAݽO$SEʵ+wݼy]<ÎG(_UOe
Ryl-.#{fvX|ݳ H^P(i<+ɱlتҙ+:K_:SUQqBTY^Y}Eڽm.M^
\$ F5C^<~4H:;.I:]̷v)ߧrv~FY"bHkbR7oHdV7ϷHDw
>-jkטW[#D_$T&ƺFm`=iI)uVg$JṞ$DGS郵մ8xŃV