Journal of Aging Research
Volume 2018 (2018), Article ID 2126368, 10 pages
https://doi.org/10.1155/2018/2126368

Research Article

Positive Mental Attitude Associated with Lower 35-Year Mortality: The Leisure World Cohort Study

Annlia Paganini-Hill,¹ Claudia H. Kawas,1,2,3 and María M. Corrada1,3,4

¹Department of Neurology, School of Medicine, University of California, Irvine, California, USA
²Department of Neurobiology & Behavior, School of Biological Sciences, University of California, Irvine, California, USA
³Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
⁴Department of Epidemiology, School of Medicine, University of California, Irvine, California, USA

Correspondence should be addressed to Annlia Paganini-Hill; annliahi@usc.edu

Received 3 July 2018; Revised 22 October 2018; Accepted 25 October 2018; Published 25 November 2018

Academic Editor: Carmela R. Balistreri

Copyright © 2018 Annlia Paganini-Hill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Background. Although emerging research has suggested that “positive psychological well-being” is associated with better health outcomes, studies of long-term health and mortality in the elderly are limited. This study assessed the relationship of mental attitude and mortality in older adults followed up for 35 years. Methods. In the 1980s, the Leisure World Cohort Study recruited residents of a California retirement community to a prospective cohort study of health promotion and disease prevention. Participants completed a postal survey including seven positively worded items from the Zung self-rating depression scale. Age-adjusted and multivariable-adjusted (for lifestyle behaviors and disease conditions) hazard ratios (HRs) for death were calculated using Cox regression for 8682 women and 4992 men (median age at entry, 74 years). During follow-up (1981–2016), 13,405 participants died (median age at death, 88 years). Results. In both women and men, HRs for death were significantly related to mental attitude with increasing risk with decreasing positive responses for total attitude and the seven individual items. The multivariable-adjusted HR (95% CI) for death for individuals in the lowest vs. highest quarter of total attitude was 1.24 (1.16, 1.32) for women and 1.30 (1.19, 1.41) for men. Some attenuation in the observed associations occurred after adjustment for potential confounders and after elimination of the first five years of follow-up. Conclusions. Our study suggests that persons with negative attitude have an increased risk of death even after many years of follow-up. Research into strategies to improve mental outlook may help improve the quantity as well as the quality of life.

1. Introduction

The number of elderly adults continues to increase as does the need for them to lead lives in good mental and physical condition. Although “positive mental attitude,” “psychological well-being,” “life satisfaction,” and “happiness” are vague concepts, emerging research suggests that they are associated with better health outcomes [1–5] while their opposites “negative mental attitude,” “life dissatisfaction,” “pessimism,” and “depression and depressive symptoms” are associated with poorer outcomes [6–9].

Studies of mental attitude and long-term health (including mortality) in the elderly are limited by sample size and length of follow-up. Four prospective cohort studies of all-cause mortality in the elderly have included more than 10,000 participants [10–13], and only one of these included both sexes [10]. Follow-up has been greater than 10 years in only three studies [10, 14, 15]. Thus, little is known about whether positive mental attitude has any predictive value in old age over a long-time span.

In 1981, we undertook a prospective cohort study of nearly 14,000 elderly women and men in a California retirement community with the aim of studying factors associated with longevity and successful aging. We report here the results of positive mental attitude (seven items from the Zung self-rating depression scale [16]) on all-cause mortality with 35 years of follow-up. To determine whether mental attitude is associated with mortality independently of known predictors of mortality, we adjusted for medical history (hypertension, angina, heart attack, stroke, cancer, diabetes, and arthritis), body mass index, and lifestyle practices (smoking, alcohol consumption, caffeine intake, and exercise). In addition, the large size of our cohort allowed us to analyze the two sexes separately. As those with health problems may have a poorer mental attitude in the time immediately preceding death, the elimination of early deaths permitted us to determine the long-term effect of mental attitude. Thus, our study adds to the existing knowledge on well-being and mortality in the aged.

2. Methods

2.1. Participants and Vital Status

The Leisure World Cohort Study was established in the early 1980s when 13,978 residents (8,877 women and 5,101 men) of a California retirement community (Leisure World Laguna Hills) completed a postal health survey. Recruitment procedures have been previously described [17, 18]. Briefly, residents were recruited in 4 waves: those who owned homes in Leisure World on June 1, 1981, and new residents who had moved into the community and were living there on June 1, 1982, June 1, 1983, and October 1, 1985. Recruitment included mailing the survey with simultaneous advertisements describing the study in the local community newspaper, second and third mailings to nonrespondents, and then telephoning nonrespondents (if a local phone number was listed). The baseline survey asked for information on demographic characteristics (sex, marital status, height, and weight), basic medical history (high blood pressure, heart attack, angina, stroke, diabetes, rheumatoid arthritis, glaucoma, fractures, and cancer), and several personal habits (smoking, alcohol consumption, caffeine intake, vitamin supplement use, and physical activity). The Leisure World population and the cohort are predominantly Caucasian, well-educated, and upper-middle class. Vital status of cohort members was determined by periodic resurvey, annual mailings, search of death indexes, and ascertainment of death certificates. Participants were followed to death or December, 31, 2016, whichever came first. To date, 25 cohort members have been lost to follow-up, including 5 who moved out of the country.

This study was approved by the Institutional Review Boards of the University of Southern California and the University of California, Irvine.

2.2. Mental Attitude Variables

The survey included only the seven positively worded items from the 20-item Zung self-rating depression scale [16]; the other 13 items were not asked. Participants were asked to read the seven items (Table 1) and to indicate “how much of the time the statement describes how you have been feeling during the past week.” Possible responses were “none or a little of the time, some of the time, a good part of the time, most or all of the time” and were scored 1 through 4, respectively. A total attitude score (7–28) was calculated by summing the seven responses. A score of 7 indicates that the subject selected “none or a little of the time” as a response to all items and represents the poorest possible mental outlook. A score of 28 indicates that all responses were “most or all of the time” and represents the most positive mental outlook. To account for items with missing responses, we calculated the total attitude score in three ways: (1) calculating the total score only for participants without missing responses, (2) assigning a nonresponse item the lowest score of 1 and including it in the total attitude score, and (3) assigning a nonresponse item the highest score of 4 and including it in the total attitude score. For analyses of individual items, those with missing responses were excluded from the analyses.

Table 1: Attitude questions from the Zung self-rated depression scale in the Leisure World Cohort Study, 1980s, .

Attitude statement
No response
None or a little of the time (1)
Some of the time (2)
A good part of the time (3)
Most or all of the time (4)

(%)
(%)
(%)
(%)
(%)

My mind is as clear as it used to be
104 (0.8%)
233 (1.7%)
823 (6.0%)
3139 (23%)
9375 (69%)

I find it easy to do the things I used to do
156 (1.1%)
969 (7.1%)
3080 (23%)
5214 (38%)
4255 (31%)

I feel hopeful about the future
263 (1.9%)
530 (3.9%)
1438 (11%)
3170 (23%)
8273 (61%)

I find it easy to make decisions
124 (0.9%)
444 (3.2%)
1596 (12%)
4198 (31%)
7312 (53%)

I feel that I am useful and needed
178 (1.3%)
594 (4.3%)
1573 (12%)
2895 (21%)
8434 (62%)

My life is pretty full
157 (1.1%)
540 (3.9%)
1321 (9.7%)
3286 (24%)
8370 (61%)

I still enjoy the things I used to
120 (0.9%)
514 (3.8%)
1662 (12%)
3374 (25%)
8004 (59%)

Quarters of total attitude (sum of scores for the above seven items)

Q1 7–20
Q2 21–24
Q3 25–26
Q4 27–28

All persons: those with no response on any of the seven items included in no response category
657 (4.8%)
2646 (19%)
3421 (25%)
2757 (20%)
4193 (31%)

All persons: if no response on any item that response recoded as 1 = “none or a little of the time”

3057 (22%)
3633 (27%)
2791 (20%)
4193 (31%)

All persons: if no response on any item that response recoded as 4 = “most or all of the time”

2789 (20%)
3617 (26%)
2917 (21%)
4357 (32%)

2.3. Potential Confounding Variables

Several factors asked on the same survey with the mental attitude variables were previously found to be related to mortality in this cohort. We included these in analyses as potential confounders. Medical history was elicited in response to a question “Has a doctor ever told you that you have any of these conditions?” Smoking refers to cigarette use [19]. We estimated daily caffeine intake by summing the frequency of consumption of each beverage and chocolate multiplied by its average caffeine content (milligrams/standard unit) as 115, 3, 50, 50, and 6 for regular coffee, decaffeinated coffee, tea, cola soft drinks, and chocolate, respectively [20]. Consumption of alcoholic beverages was asked separately for wine, beer, and hard liquor and combined into number of alcoholic drinks per day [21]. Body mass index (BMI) (weight (kilograms)/height² (meters)) was calculated based on self-reported height and weight at baseline and categorized according to federal guidelines: underweight (<18.5), normal weight (18.5–24.9), overweight (25–29.9), and obese (30+) [22]. Exercise included active outdoor activities (e.g., swimming, biking, jogging, tennis, and vigorous walking) and active indoor activities (e.g., exercising and dancing). The time spent per day in active activities was calculated by summing the reported times spent in active outdoor and active indoor activities [23]. Previous reports present details of data collection [17–24].

2.4. Statistical Analysis

Differences between women and men were tested using t-tests for continuous variables and chi-squared tests for categorical variables. Hazard ratios (HRs) for the association between mental attitude and mortality were calculated separately for women and men using Cox regression analysis [25] with age as the time scale. Participants contributed person-years from age at baseline survey (delayed entry) to age at death or December 31, 2016, whichever occurred first. Total attitude (continuous and quartile categories) as well as the seven individual items were analyzed as independent variables. The reference category for the HRs was “good mental attitude,” i.e., response of “most or all of the time” for the seven individual items and a total attitude score of 27-28. To control for potential confounders, we performed analysis adjusting for factors previously found to be related to mortality in this cohort: smoking (never, past, and current), alcohol intake (0, ≤1, 2-3, and 4+ drinks/day), caffeine (<50, 50–99, 100–199, 200–399, and 400+ mg/day), exercise (0, ¼, ½, ¾-1¾, and 2+ hour/day), BMI (underweight, normal, overweight, and obese), and histories (yes/no) of hypertension, angina, heart attack, stroke, diabetes, rheumatoid arthritis, and cancer [19–23]. To account for the possibility that recent disease development may have altered attitude as well as be related to mortality, we repeated the analyses after excluding the first five years of follow-up. We performed sensitivity analyses to explore how results would change if the total attitude score on the Zung scale was computed with missing items assigned to either the lowest value (1 = none or little of the time) or alternatively to the highest value (4 = all or most of the time). Statistical analyses were performed using SAS® version 9.4 (SAS Institute Inc., Cary, NC). All tests were two-sided, and no adjustment in the -values was made for multiple comparisons.

3. Results

After excluding 89 subjects with missing information on all seven attitude items and an additional 215 with missing information on potential confounding variables, data on 8682 women and 4992 men were analyzed. At study entry, the participants ranged in age from 44 to 101 years (median, 74 years). By December 31, 2016, 13,405 (98%) had died at ages 59 to 110 years (median, 88 years).

Table 1 presents the responses to the seven individual attitude questions. While 13,017 (95%) participants answered all seven questions, 443 did not answer one, 123 two, 28 three, 20 four, 9 five, and 34 six. The distributions of responses differed among the seven statements. The statement “I find it easy to do the things I used to do” had the least number of “most or all of the time” responses (31%) and far fewer than the other statements (53–69%).

Table 2 gives selected characteristics of the participants by sex. Men were on average older than women at study entry (74 vs. 73 years), and a smaller proportion were alive at the end of follow-up (0.9% vs. 2.7%). Men also had on average a greater BMI, exercised more, and consumed more alcohol and caffeine than women, but a smaller proportion never smoked. More men had a history of angina, heart attack, stroke, and diabetes, while more women had high blood pressure, cancer, and rheumatoid arthritis. Women were more likely to have a higher attitude score than men (score ≥25: 52% vs. 50%). All differences were statistically significant ().

Table 2: Baseline characteristics in the Leisure World Cohort Study, 1980s.

Characteristic
Total ()
Men ()
Women ()

Mean ± SD

Age at baseline, years
73.6 ± 7.3
74.3 ± 7.2
73.2 ± 7.4

Age at last follow-up, years
87.6 ± 7.4
86.1 ± 7.1
88.5 ± 7.4

Follow-up years
14.0 ± 8.3
11.7 ± 7.7
15.3 ± 8.3

Body mass index, kg/m²
23.5 ± 3.3
24.2 ± 2.9
23.1 ± 3.4

Exercise, hours/day
1.0 ± 1.2
1.1 ± 1.3
0.9 ± 1.1

Alcohol, drinks/day
1.4 ± 1.4
1.6 ± 1.5
1.2 ± 1.2

Caffeine, mg/day
171 ± 168
176 ± 172
168 ± 166

(%)

History of disease

    High blood pressure
5335 (39%)
1803 (36%)
3532 (41%)

    Angina
1547 (11%)
728 (15%)
819 (9.4%)

    Heart attack
1396 (10%)
828 (17%)
568 (6.5%)

    Stroke
670 (4.9%)
351 (7.0%)
319 (3.7%)

    Cancer
1593 (12%)
467 (9.4%)
1126 (13%)

    Diabetes
841 (6.2%)
414 (8.3%)
427 (4.9%)

    Rheumatoid arthritis
807 (5.9%)
220 (4.4%)
587 (6.8%)

Cigarette use

    Never
6436 (47%)
1664 (33%)
4772 (55%)

    Past
5724 (42%)
2900 (58%)
2824 (33%)

    Current
1514 (11%)
428 (8.6%)
1086 (12%)

Total attitude

    Missing response
657 (4.8%)
207 (4.1%)
450 (5.2%)

    7–20
2646 (19%)
995 (20%)
1651 (19%)

    21–24
3421 (25%)
1286 (26%)
2135 (25%)

    25–26
2757 (20%)
1051 (21%)
1706 (20%)

    27–28
4193 (31%)
1453 (29%)
2740 (32%)

Alive at follow-up
269 (2.0%)
44 (0.9%)
225 (2.6%)

Abbreviation: SD, standard deviation. for all differences between men and women except caffeine () and total attitude ().

HRs of mortality for the seven individual attitude items and for the total attitude score are shown in Table 3 for women and in Table 4 for men. Analysis of total attitude score by quartiles showed higher mortality with lower scores (more negative attitude) in both women and men (Figure 1). In the model fully adjusted for age and potential confounders, women with scores of <21 had 24% greater risk of death and men had a 30% greater risk of death compared with persons with scores of 27-28; these risks were 22% and 24% after exclusion of the first five years of follow-up including 854 deaths in women and 1102 deaths in men. As a continuous variable, risk of death significantly increased 2% (women) and 4% (men) for each unit decrease in the total attitude score. In sensitivity analyses that calculated the total score by assigning either the lowest value (1 = none or little of the time) or the highest value (4 = all or most of the time) to the missing items, the results were very similar to those where individuals with missing items were excluded when computing the total score (Tables 3 and 4).

Table 3: Attitude and hazard ratio of death among women: the Leisure World Cohort Study, 1981–2016.

All subjects ()
Excluding first five years of follow-up ()

No. subjects†
No. deaths
Model 1a
Model 2b
No. subjects†
No. deaths
Model 1a
Model 2b

HR
95% CI
HR
95% CI
HR
95% CI
HR
95% CI

My mind is as clear as it used to be

    None or little of the time
124
121
1.43
1.20, 1.72
1.28
1.07, 1.54
78
75
1.14
0.91, 1.43
1.02
0.81, 1.29

    Some of the time
495
491
1.39
1.27 1.52
1.27
1.16, 1.40
406
402
1.43
1.30, 1.59
1.33
1.20, 1.47

    A good part of the time
1937
1901
1.09
1.03, 1.15
1.07
1.01, 1.12
1716
1680
1.09
1.03, 1.15
1.07
1.01, 1.13

    Most or all of the time
6048
5866
1.00

1.00

5558
5366
1.00

1.00

I find it easy to do the things I used to do

    None or little of the time
544
539
1.65
1.51, 1.82
1.39
1.26, 1.53
373
368
1.54
1.38, 1.72
1.30
1.16, 1.46

    Some of the time
1920
1898
1.29
1.22, 1.37
1.18
1.11, 1.26
1635
1613
1.30
1.22, 1.38
1.18
1.11, 1.26

    A good part of the time
3283
3214
1.03
0.98, 1.09
0.99
0.94, 1.04
3072
3003
1.05
0.99, 1.11
1.01
0.95, 1.06

    Most or all of the time
2826
2697
1.00

1.00

2664
2535
1.00

1.00

I feel hopeful about the future

    None or little of the time
331
328
1.53
1.36, 1.71
1.34
1.20, 1.50
242
239
1.46
1.28, 1.66
1.29
1.13, 1.47

    Some of the time
924
911
1.25
1.16, 1.34
1.16
1.08, 1.24
785
772
1.22
1.13, 1.31
1.13
1.05, 1.22

    A good part of the time
1973
1941
1.09
1.04, 1.15
1.07
1.02, 1.13
1767
1735
1.08
1.02, 1.14
1.07
1.01, 1.13

    Most or all of the time
5275
5099
1.00

1.00

4885
4709
1.00

1.00

I find it easy to make decisions

    None or little of the time
289
282
1.18
1.05, 1.33
1.10
0.97, 1.24
213
206
1.09
0.95, 1.26
1.04
0.90, 1.19

    Some of the time
1101
1080
1.10
1.03, 1.17
1.05
0.99, 1.13
967
946
1.11
1.03, 1.18
1.07
0.99, 1.14

    A good part of the time
2698
2642
0.96
0.92, 1.01
0.96
0.91, 1.01
2451
2395
0.97
0.92, 1.02
0.96
0.91, 1.01

    Most or all of the time
4509
4370
1.00

1.00

4125
3986
1.00

1.00

I feel that I am useful and needed

    None or little of the time
412
406
1.28
1.16, 1.42
1.14
1.03, 1.26
305
299
1.21
1.08, 1.36
1.09
0.97, 1.22

    Some of the time
1038
1027
1.24
1.16, 1.33
1.16
1.09, 1.24
876
865
1.21
1.13, 1.31
1.14
1.06, 1.23

    A good part of the time
1750
1705
1.03
0.97, 1.08
1.02
0.96, 1.08
1581
1536
1.02
0.96, 1.08
1.01
0.95, 1.07

    Most or all of the time
5364
5203
1.00

1.00

4976
4815
1.00

1.00

My life is pretty full

    None or little of the time
316
310
1.58
1.41, 1.78
1.33
1.19, 1.50
228
222
1.45
1.26, 1.66
1.22
1.06, 1.40

    Some of the time
856
848
1.38
1.28, 1.48
1.25
1.16, 1.35
701
693
1.33
1.23, 1.44
1.21
1.12, 1.31

    A good part of the time
1996
1955
1.14
1.08, 1.20
1.09
1.03, 1.14
1788
1747
1.14
1.08, 1.20
1.09
1.03, 1.15

    Most or all of the time
5412
5242
1.00

1.00

5034
4864
1.00

1.00

I still enjoy the things I used to

    None or little of the time
289
285
1.62
1.44, 1.82
1.39
1.23, 1.57
200
196
1.44
1.25, 1.67
1.27
1.10, 1.46

    Some of the time
990
973
1.29
1.20, 1.38
1.18
1.10, 1.26
820
803
1.27
1.18, 1.37
1.17
1.08, 1.26

    A good part of the time
2011
1978
1.07
1.02, 1.13
1.02
0.97, 1.08
1812
1779
1.07
1.01, 1.13
1.02
0.97, 1.08

    Most or all of the time
5304
5133
1.00

1.00

4925
4754
1.00

1.00

Attitude score (persons with missing items excluded)

    <21
1651
1632
1.38
1.29, 1.46
1.24
1.16, 1.32
1354
1335
1.35
1.26, 1.44
1.22
1.14, 1.31

    21–24
2135
2092
1.12
1.05, 1.18
1.07
1.01, 1.13
1927
1883
1.11
1.05, 1.18
1.06
1.00, 1.13

    25-26
1706
1662
1.02
0.96, 1.09
0.99
0.94, 1.06
1589
1543
1.03
0.96, 1.10
1.00
0.94, 1.07

    27-28
2740
2625
1.00

1.00

2592
2472
1.00

1.00

Attitude score (missing items given score of 1)

    <21
1925
1904
1.37
1.29, 1.45
1.23
1.16, 1.31
1561
1540
1.34
1.26, 1.43
1.22
1.14, 1.30

    21–24
2289
2244
1.12
1.06, 1.19
1.06
1.00, 1.13
2067
2021
1.12
1.06, 1.19
1.07
1.01, 1.13

    25-26
1728
1684
1.02
0.96, 1.09
1.00
0.94, 1.06
1608
1562
1.03
0.97, 1.10
1.00
0.94, 1.07

    27-28
2740
2625
1.00

1.00

2592
2472
1.00

1.00

Attitude score (missing items given score of 4)

    <21
1741
1721
1.38
1.30, 1.47
1.24
1.17, 1.32
1418
1397
1.34
1.26, 1.44
1.22
1.14, 1.30

    21–24
2272
2227
1.12
1.06, 1.18
1.07
1.01, 1.13
2039
1994
1.11
1.05, 1.18
1.07
1.01, 1.13

    25-26
1823
1779
1.04
0.98, 1.10
1.01
0.95, 1.07
1686
1642
1.04
0.97, 1.10
1.01
0.95, 1.08

    27-28
2846
2730
1.00

1.00

2686
2570
1.00

1.00

Abbreviations: CI, confidence interval; HR, hazard ratio. †Subjects do not always total 8682 or 7828 due to those with missing values. aModel 1: adjusted for age (i.e., age as time scale). bModel 2: adjusted for age, smoking, body mass index, exercise, alcohol intake, caffeine consumption, and histories of hypertension, angina, heart attack, stroke, diabetes, rheumatoid arthritis, and cancer.

Table 4: Attitude and hazard ratio of death among men: the Leisure World Cohort Study, 1981–2016.

All subjects ()
Excluding first five years of follow-up ()

No. subjects†
No. deaths
Model 1a
Model 2b
No. subjects†
No. deaths
Model 1a
Model 2b

HR
95% CI
HR
95% CI
HR
95% CI
HR
95% CI

My mind is as clear as it used to be

    None or little of the time
109
109
1.55
1.27, 1.88
1.41
1.16, 1.71
55
55
1.38
1.06, 1.80
1.34
1.02, 1.75

    Some of the time
328
327
1.47
1.31, 1.65
1.31
1.17, 1.47
203
202
1.44
1.25, 1.66
1.30
1.13, 1.50

    A good part of the time
1202
1194
1.10
1.03, 1.17
1.06
0.99, 1.13
957
949
1.16
1.08, 1.25
1.13
1.05, 1.21

    Most or all of the time
3327
3292
1.00

1.00

2749
2713
1.00

1.00

I find it easy to do the things I used to do

    None or little of the time
425
425
2.02
1.81, 2.25
1.64
1.46, 1.83
205
205
1.76
1.52, 2.05
1.49
1.28, 1.73

    Some of the time
1160
1157
1.32
1.22, 1.42
1.19
1.10, 1.28
848
845
1.32
1.21, 1.44
1.20
1.10, 1.32

    A good part of the time
1931
1914
1.10
1.03, 1.18
1.05
0.98, 1.13
1645
1628
1.13
1.05, 1.22
1.09
1.01, 1.17

    Most or all of the time
1429
1405
1.00

1.00

1250
1225
1.00

1.00

I feel hopeful about the future

    None or little of the time
199
199
1.79
1.55, 2.07
1.51
1.31, 1.75
104
104
1.62
1.33, 1.98
1.46
1.20, 1.79

    Some of the time
514
512
1.31
1.19, 1.44
1.17
1.06, 1.29
353
351
1.23
1.10, 1.38
1.11
0.99, 1.24

    A good part of the time
1197
1188
1.04
0.98, 1.12
0.99
0.92, 1.06
953
944
1.04
0.96, 1.12
0.99
0.92, 1.07

    Most or all of the time
2998
2966
1.00

1.00

2520
2487
1.00

1.00

I find it easy to make decisions

    None or little of the time
155
155
1.90
1.62, 2.24
1.53
1.30, 1.80
71
71
1.83
1.44, 2.31
1.48
1.17, 1.89

    Some of the time
495
494
1.17
1.07, 1.29
1.10
1.00, 1.21
354
353
1.14
1.02, 1.27
1.07
0.96, 1.20

    A good part of the time
1500
1489
1.07
1.01, 1.14
1.03
0.96, 1.09
1207
1196
1.09
1.01, 1.17
1.04
0.97, 1.12

    Most or all of the time
2803
2771
1.00

1.00

2317
2284
1.00

1.00

I feel that I am useful and needed

    None or little of the time
182
181
1.83
1.57, 2.12
1.64
1.40, 1.90
88
87
1.53
1.23, 1.89
1.44
1.16, 1.78

    Some of the time
535
531
1.29
1.17, 1.41
1.14
1.04, 1.25
374
370
1.20
1.07, 1.33
1.06
0.95, 1.18

    A good part of the time
1145
1136
1.10
1.02, 1.17
1.08
1.01, 1.16
907
898
1.06
0.98, 1.14
1.05
0.97, 1.13

    Most or all of the time
3070
3041
1.00

1.00

2575
2546
1.00

1.00

My life is pretty full

    None or little of the time
224
223
1.89
1.64, 2.16
1.56
1.36, 1.80
111
110
1.59
1.31, 1.92
1.38
1.14, 1.68

    Some of the time
465
462
1.37
1.24, 1.51
1.20
1.09, 1.33
306
303
1.25
1.11, 1.41
1.10
0.97, 1.24

    A good part of the time
1290
1279
1.14
1.07, 1.22
1.06
0.99, 1.14
1022
1011
1.14
1.06, 1.23
1.07
1.00, 1.15

    Most or all of the time
2958
2929
1.00

1.00

2509
2480
1.00

1.00

I still enjoy the things I used to

    None or little of the time
225
225
2.23
1.95, 2.56
1.76
1.53, 2.03
86
86
1.86
1.50, 2.31
1.45
1.16, 1.81

    Some of the time
672
668
1.36
1.25, 1.48
1.20
1.10, 1.31
455
451
1.31
1.18, 1.45
1.18
1.06, 1.31

    A good part of the time
1363
1354
1.11
1.04, 1.19
1.05
0.99, 1.13
1116
1107
1.14
1.06, 1.22
1.08
1.00, 1.16

    Most or all of the time
2700
2669
1.00

1.00

2305
2274
1.00

1.00

Attitude score (persons with missing items excluded)

    <21
995
993
1.54
1.42, 1.67
1.30
1.19, 1.41
631
629
1.43
1.30, 1.58
1.24
1.12, 1.37

    21–24
1286
1273
1.16
1.08, 1.25
1.09
1.01, 1.18
1056
1043
1.19
1.10, 1.29
1.13
1.04, 1.23

    25-26
1051
1041
1.13
1.04, 1.22
1.06
0.98 1.15
893
883
1.17
1.08, 1.28
1.12
1.02, 1.22

    27-28
1453
1435
1.00

1.00

1270
1252
1.00

1.00

Attitude score (missing items given score of 1)

    <21
1132
1130
1.55
1.43, 1.67
1.32
1.21, 1.43
706
704
1.43
1.31, 1.57
1.25
1.14, 1.38

    21–24
1344
1330
1.15
1.07, 1.24
1.08
1.00, 1.16
1103
1089
1.18
1.09, 1.28
1.12
1.03, 1.22

    25-26
1063
1053
1.13
1.04, 1.23
1.06
0.98, 1.15
901
891
1.18
1.08, 1.28
1.12
1.03, 1.22

    27-28
1453
1435
1.00

1.00

1270
1252
1.00

1.00

Attitude score (missing items given score of 4)

    <21
1048
1046
1.55
1.43, 1.67
1.31
1.21, 1.42
655
653
1.43
1.30, 1.57
1.24
1.13, 1.37

    21–24
1345
1332
1.17
1.09, 1.26
1.10
1.02, 1.18
1092
1079
1.20
1.10, 1.30
1.13
1.04, 1.23

    25-26
1094
1084
1.13
1.04, 1.22
1.06
0.98 1.14
924
914
1.17
1.08, 1.28
1.11
1.02, 1.21

    27-28
1505
1486
1.00

1.00

1309
1290
1.00

1.00

Abbreviations: CI, confidence interval; HR, hazard ratio. †Subjects do not always total 4992 or 3980 due to those with missing values. aModel 1: adjusted for age (i.e., age as time scale). bModel 2: adjusted for age, smoking, body mass index, exercise, alcohol intake, caffeine consumption, and histories of hypertension, angina, heart attack, stroke, diabetes, rheumatoid arthritis, and cancer.

Figure 1: Attitude score and hazard ratios of death: the Leisure World Cohort Study, 1981–2016. Note: data shown are from analyses of total attitude score as quartile categories excluding persons with missing items. HRs and 95% confidence intervals derived from Cox regression analysis model 2, which adjusts for age (as the time scale), smoking, body mass index, exercise, alcohol intake, caffeine consumption, and histories of hypertension, angina, heart attack, stroke, diabetes, rheumatoid arthritis, and cancer.

The seven attitude items similarly showed a higher risk of death with increasing level of negative attitude. Adjustment for potential confounders resulted in modest attenuation of risks (less than 20%), and the HRs for poor mental attitude (responses of “none or little of the time” and “some of the time”) remained statistically significant for all items except “I find it easy to make decisions” in women. For all seven items, the HRs for the poorest mental attitude (response of “none or little of the time”) were larger in men than women (about 20% or more except for “My mind is clear as it used to be”). With elimination of the first five years of follow-up, the age-adjusted HRs for women changed by less than 10% for all items except “My mind is as clear as it used to be,” where the HR for the poorest mental attitude (response of “none or little of the time”) was reduced from 1.43 to 1.14. The multivariable-adjusted HRs showed smaller reductions, and the HRs for the poorest mental attitude (response of “none or a little of the time”) for three of the seven items (“mind is clear,” “easy to make decisions,” and “feel useful and needed”) were no longer statistically significant. For men with the elimination of the first five years of follow-up, the age-adjusted HRs for the poorest mental attitude (response of “none or a little of the time”) for all seven items were reduced 10–15% but remained statistically significant; the HRs for other response categories changed by less than 10%. The multivariable-adjusted HRs showed smaller reductions, and HRs for the poorest mental attitude remained statistically significant for all seven items.

4. Discussion

We found modest increased risks of death with poor mental attitude that persisted after adjustment for potential confounders including disease history and lifestyle practices. The observed risks, especially for the most negative attitudes, were attenuated after eliminating the first five years of follow-up suggesting that diseases leading to early death might be the cause of some of the negativity. The associations found after adjustment and elimination of the first five years of follow-up may thus be more accurate from a perspective of a causal relationship. Although mental attitude is associated with lifestyle practices and disease states which are also related with mortality, a poor attitude appears to confer additional risk of death.

Those with a positive mental attitude or psychological well-being differ from those with a more negative outlook on a number of health processes—healthier lipid profile, lower levels of inflammatory markers, higher levels of serum antioxidants, better immune responses, and healthier autonomic function [26]—and on a number of healthier behaviors—increased physical activity, nonsmoking, healthier diets, and higher quality of sleep [27]. These may partly serve as mechanisms for the association of mental attitude with mortality.

Previous prospective population-based studies have evaluated mental attitude and all-cause mortality in older population groups [10–15, 28–35]. However, follow-up has generally been less than 10 years, the cohort size less than 10,000, or the study has included only one sex. Table 5 summarizes these studies. Similar to our study, all previous studies except two [12, 28] found that persons with the most positive attitude (measured in different ways) had the lowest risk of death, and that the risk was attenuated after adjustment of health conditions and lifestyle factors. An inverse dose-response relationship (decreased risk of mortality with increasing levels of positive mental attitude) was seen in both women and men and in studies conducted in diverse countries (USA, Canada, England, the Netherlands, Spain, Sweden, Finland, and China).

Table 5: Prospective cohort studies of mental attitude and mortality in the elderly.

First author, date [reference]
Study name
Population
Number
Age (years)
Follow-up (years)
Sex
Mental attitude instrument
HR, 95% CI†Age- and sex-adjusted Most adjusted model

Gitlay, 2004 [30]
Arnhem Elderly Study
The Netherlands
999
65–85
Mean = 9
M,F
Scale of Subjective Well-Being for Older Persons
0.55, 0.42–0.77
0.71, 0.52–0.97

Pitkala, 2004 [32]
Helsinki Aging Study
Finland
491
75, 80, 85
10
M,F
6 questions on positive life orientation
0.67, 0.53–0.87‡
0.89, 0.83–0.93

Tindle, 2009 [13]
Women’s Health Initiative
USA
97,253
50–79
8
F
Life Orientation Test-Revised
—
0.86, 0.79–0.93

Koopmans, 2010 [14]
Arnhem Elderly Study
The Netherlands
861
65–85
15
M,F
2 “happiness” questions
0.78, 0.64–0.95
0.92, 0.75–1.14

Benito-Leon, 2010 [29]
Neurological Disorders in Central Spain
2516
65+
7
M,F
Philadelphia Geriatric Center Morale Scale
1.60, 1.29–2.21‡
1.35, 1.00–1.81

Tilvis, 2012 [35]
National Sample
Finland
2490
>75
5
M,F
6 questions on positive life orientation
0.65, 0.53–0.81
0.85, 0.67–1.08

Niklasson, 2015 [31]
GERDA
Sweden and Finland
646
85+
5
M,F
Philadelphia Geriatric Center Morale Scale
1.73, 1.33–2.26
1.36, 1.03–1.80

St John, 2015 [33]
Manitoba Study of Health and Aging, Canada
1751
65+
5
M,F
Terrible-Delightful Scale
0.75, 0.66–0.86
0.90, 0.78–1.04

Steptoe, 2015 [34]
English Longitudinal Study of Aging
9050
Mean = 65
Mean = 8
M,F
Eudemonic well-being
0.42, 0.36–0.49
0.70, 0.58–0.83

Anthony, 2016 [28]
Rancho Bernardo Study
USA
876
50+
< = 12 mean = 8
M,F
Life Orientation Test-Revised
0.98, 0.94–1.02
0.99, 0.94–1.03

Gong, 2016 [10]
Chinese Longitudinal Healthy Longevity Survey
18,676
80–122
16
M,F
7 items on psychological well-being
—
0.84, 0.79–0.88

Liu, 2016 [12]
Million Women Study
United Kingdom
719,671
50–69
10
F
“How often do you feel happy?”
1.29, 1.25–1.33
0.98, 0.94–1.01

Kim, 2017 [11]
Nurses’ Health Study
USA
70,021
Mean = 70
6
F
Life Orientation Test-Revised
0.71, 0.66–0.76∗
0.91, 0.85–0.97

Okely, 2018 [15]
Survey of Health Aging and Retirement in Europe
13,596
50+
∼12
M,F
CASP-12
0.41, 0.38–0.43
0.57, 0.53–0.61

†HR for high vs. low category of positive mental attitude, except for Benito-Leon, Niklasson, and Liu studies which compared low vs. high category. ‡Unadjusted HR. ∗Adjusted for additional demographic factors as well.

As in previous studies, risk of death was attenuated after adjustment of health conditions and lifestyle factors associated with both mental attitude and survival. To reduce concerns that recent changes in mental attitude may be due to underlying illness, we analyzed the data excluding participants who died within five years of study baseline. Likewise, early deaths were eliminated in the Nurses’ Health Study (within two years) [11] and the Million Women Study (within five years) [12] to reduce these concerns about reverse causality. However, mental attitude may alter the time course of disease processes and influence health behaviors directly, so the possibility of overadjustment exists and we may be adjusting for the effect of intermediate factors in the causal pathway.

Although some studies have evaluated the association of the Zung self-rating depression scale with mortality [36–38], only those reporting results on the individual items can be directly compared to our study. Takeida and colleagues analyzed the Zung scale as a predictor of death in a Japanese cohort of 2,166 aged 60–74 years and followed five years [39]. Of the seven items included in our study, they found six significantly related to mortality. Those items and their relative risks (RR) were “I find it easy to do the things I used to” (RR = 3.84), “My life is pretty full” (RR = 2.39), “I find it easy to make decisions” (RR = 2.27), “My mind is as clear as it used to be” (RR = 2.05), “I feel hopeful about the future” (RR = 1.67), and “I feel that I am useful and needed” (RR = 1.44). The item “I still enjoy the things I used to do” (RR = 1.35) was not related to mortality. In our older cohort, all seven items were related to mortality. That the individual items we used had a high predictive value of risk of death indicates that refusing to answer any single question does not invalidate the use of the questionnaire nor does the use of the seven rather than the 20 items of the Zung scale.

Several strengths and limitations of this study must be considered. Our data on mental attitude were self-reported using a mailed questionnaire. The seven items included in our survey were extracted from the Zung self-rating depression scale, but we did not ask the other 13 items. Thus, we are not able to compare our results with studies reporting the full Zung scale. Similar to other studies, we previously found our mental attitude score to be related to suicide in the first five years of follow-up [40]. However, conclusions regarding attitude are limited by the crudeness of measurement. Although assessing the true level of attitude is difficult, self-reported rating is suitable for ranking of individuals.

Our large cohort size allowed us to analyze men and women separately. We did this for comparison with other studies reporting sex-specific results [11, 13, 30], because of differences between men and women on baseline characteristics and mortality rates, and due to the possibility of differential response on attitude between men and women. Chang and coworkers showed significant sex differences in reporting of psychological outcomes with more women reporting negative outcomes [41]. This was also seen in several of the prospective studies of attitude and mortality [29, 31], but they did not report sex-specific HRs for death. Differential reporting may help explain the lower HRs for negative attitudes we observed in women compared with men. The cohort reported here is elderly, white, and in the upper middle socioeconomic stratum. Therefore, our results may not be generalizable to other populations.

Our study has the advantages of a prospective design, large size, long and essentially complete follow-up, and the capability to control for numerous potential confounding factors. Still our investigation is an observational study, not a randomized trial. It does, however, suggest that confounders account for only a portion of the associations between mental attitude and risk of death. However, residual confounding due to suboptimal variables or to unmeasured variables remain possibilities.

5. Conclusions

Results in this large elderly cohort with long follow-up are consistent with a modest relationship between mental attitude and long-term mortality. The development of interventions to foster a positive outlook may improve the personal and public health of the elderly and prolong life.

Abbreviations

BMI: | Body mass index
CI: | Confidence interval
HR: | Hazard ratio
PGCMS: | Philadelphia Geriatric Center Morale Scale
LOT-R: | Life Orientation Test-Revised
RR: | Relative risk.

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Acknowledgments

This work was supported by the National Institutes of Health under Grant nos. R01CA32197 and R01AG21055, Wyeth-Ayerst Laboratories, and the Earl Carrol Trust Fund.

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