Two New 1 , 1 , 3 , 3-Tetramethylguanidinium Halochromates ( C 5 H 14 N 3 CrO 3 X ) ( X : Cl , F ) : Efficient Reagents for Oxidation of Organic Substrates under Solvent-Free Conditions and Microwave Irradiation

Two new mild oxidizing agents 1,1,3,3-tetramethylguanidinium fluorochromate (TMGFC) and 1,1,3,3-tetramethylguanidinium chlorochromate (TMGCC) were prepared in high yields by reacting tetramethylguanidine with CrO 3 and related acid. These reagents are suitable to oxidize various primary and secondary alcohols and oximes to the corresponding carbonyl compounds under solvent-free conditions and microwave irradiation.


Introduction
Oxidation of various organic compounds under mild conditions is of great importance in synthetic organic chemistry [1].Chromium(VI) is the most widely employed among oxidizing agents based upon higher-valent transition metal oxo derivatives such as reagents derived from ruthenium, osmium, manganese, and vanadium.Since the appearance of Collins reagent [2], significant improvements are achieved in the development of new Cr(VI) based oxidizing agents for the effective and selective oxidation of organic substrates, in particular alcohols, under mild conditions.Some of the important entries in the list of reagents are pyridinium chlorochromate (PCC) [3], pyridinium dichromate (PDC) [4], pyridinium fluorochromate (PFC) [5,6], quinolinium fluorochromate (QFC) [7], 1,1,3,3-tetramethylguanidinium dichromate (TMGDC) [8], quinolinium chlorochromate (QCC) [9], and 3,5-dimethylpyrazolium fluorochromate (DmpzHFC) [10].However the chromium based reagents that have been developed so far have some limitations that cannot be overlooked.These include the inherent problems of acidity of the reagents, instability, tedious work-up, a long reaction time, overoxidation, use of toxic solvent, or a need for excess amount of reagent [11][12][13][14][15][16][17][18].Consequently, there is still scope for the search of highly efficient and mild oxidizing agents.
Recently considerable attention has been paid to solventfree reactions [19].These reactions not only are of interest from an ecological point of view, but in many cases also offer considerable synthetic advantages in terms of yield, selectivity, and simplicity of the reaction procedure.In recent years organic reactions assisted by microwave irradiation have gained special attention [20].Microwave assisted organic transformations coupled with solvent-free conditions have attracted much attention due to enhanced reaction rates, easier work-up, and facilitated purification [21][22][23][24].

Experimental
All reagents and solvents were obtained from Aldrich and used without further purification.The 1 H NMR spectrum was recorded on a Bruker Avance 300-MHz spectrometer (Germany).Elemental analysis was performed using an Elemental Micro Vario CHNS.Electrothermal melting points were determined by a 9200 digital melting point apparatus (United Kingdom) and are uncorrected.IR spectra were recorded on a Mathson 1000 FT-IR spectrometer.All microwave irradiation reactions were carried out on a Milestone Micro-Synth apparatus.

General Procedure for the Oxidation under Solvent-Free
Conditions.The oxidant (1.5-2 mmol) was added to the substrate (1 mmol) in a mortar.Starting materials were instantly mixed, ground, and kept for the appropriate period at room temperature or in an oven without any further agitation.The progress of the reaction was monitored by using TLC on silica gel (benzene : ethyl acetate = 9 : 1).Upon completion of the reaction, extraction with ether (3 × 25 mL) and evaporation of the solvent gave the corresponding carbonyl compounds.

General Procedure for the Oxidation under Microwave
Irradiation.The substrate (1 mmol) and 1.5-2 mmol oxidant were mixed.To this mixture 0.5 mL CH 2 Cl 2 was added.The mixture was subjected to microwave irradiation (1000 W).Upon completion of the reaction, extraction with ether (3 × 25 mL) and evaporation of the solvent gave the corresponding carbonyl compounds.The products formed were analyzed by their 2,4-dinitrophenylhydrazone derivatives.The precipitated 2,4-DNP was filtered off, weighed, and recrystallized from ethanol.
TMGFC and TMGCC are orange colored stable amorphous solids at room temperature.They are moisture insensitive and can be stored in polyethylene containers for long periods without decomposition.
The pH values of 0.01 M aqueous solutions of PCC, PFC, TMGFC, and TMGCC were found to be 1.75, 2.45, 3.79, and 3.89.The higher pH values of TMGFC and TMGCC compared to their companion reagents attest to their far less pronounced acidic characters.So, TMGFC and TMGCC may be proper oxidizing agents for the oxidation of acid-sensitive compounds.
TMGFC and TMGCC are highly soluble in DMF and DMSO; slightly soluble in acetonitrile and dichloromethane; and insoluble in benzene, ether, chloroform, and toluene.These results are indicative of the ionic nature of the reagents.
The effect of substrate : oxidant molar ratios has been investigated by applying 1 : 1, 1 : 1.25, 1 : 1.5, and 1 : 2 molar ratios, respectively, for the oxidation of benzyl alcohol as a model substrate under solvent-free conditions at room temperature for 30 min.The yields thus obtained were given in Table 1.To show the influence of nature of solvent on the reactivity of the oxidants, various solvents such as CH 2 Cl 2 , acetone, and DMF have been used for the oxidation of benzyl alcohol as representative substrate (Table 2).
The use of more polar solvents such as DMF and acetone resulted in moderate yields.a Yields refer to the isolated 2,4-DNP derivative [29].
In order to ascertain the efficiency of the reagents as oxidants, different types of primary and secondary alcohols and oximes were treated with the reagents by taking the molar ratio of substrate : oxidant as 1 : 1-2 under solventfree conditions at room temperature and under microwave irradiation to afford the corresponding carbonyl compounds (Scheme 1).
A probable mechanism for the oxidation with TMGCC and TMGFC is given on the basis of previously reported mechanisms [30] (Scheme 2).
a Yield was based on 2,4-dinitrophenylhydrazone derivative identified by melting point [29] (except for the 4-nitrobenzaldehyde and benzil whose melting points were taken directly).
Primary benzylic alcohols and 1-octanol were converted into their corresponding aldehydes with good to high yields (Tables 3 and 4, entries 1 and 6-10).The oxidation of these alcohols is performed devoid of overoxidation.The reactivity of the aliphatic primary and secondary alcohols seemed to be slightly lower than benzylic alcohols (Tables 3 and 4, entries 1-4).It is also noteworthy that cinnamyl alcohol (Tables 3  and 4, entry 5) was converted to cinnamaldehyde without the cleavage of the benzylic double bond and the reaction is essentially chemoselective.
Aliphatic oximes such as cyclohexanone oxime and cyclopentanone oxime were deoximated more efficiently than benzoin oxime (Tables 3 and 4, entries [13][14][15].The oxidation reactions of polycyclic aromatic hydrocarbons such as anthracene and phenanthrene were attempted by taking the molar ratio of substrate : oxidizing agent as 1 : 3 under microwave irradiation but the substrates remained intact.
During the reactions, the color of the oxidants changes from orange to brown, providing visual means for ascertaining the progress of the oxidation.
In order to show the oxidative ability of the reagents (TMGCC and TMGFC), we compared some of our results with those of PCC [20], PFC [31,32], BAAOC [33], and DmpzHFC [34] carried out under solvent-free conditions (Table 5).a Yield was based on 2,4-dinitrophenylhydrazone derivative identified by melting point [29] (except for the 4-nitrobenzaldehyde and benzil whose melting points were taken directly).

Conclusion
In conclusion, we have developed two new reagents TMGFC and TMGCC for the oxidation of alcohols and oximes.We described a solvent-free and a highly efficient microwave induced procedure for the rapid synthesis of aldehydes and ketones.These transformations enjoy the chemical and environmental advantages of solvent-free reactions.The results R 2 : alkyl, aryl, allyl, and H

Table 1 :
Oxidation of benzyl alcohol with different amounts of TMGCC and TMGFC.

Table 2 :
Oxidation of benzyl alcohol in different solvents with TMGCC and TMGFC.

Table 3 :
The oxidation of alcohols and oximes with TMGFC under solvent-free conditions at room temperature and under microwave irradiation.

Table 4 :
The oxidation of alcohols and oximes with TMGCC under solvent-free conditions at room temperature and under microwave irradiation.