Journal of Immunology Research
Volume 2019 (2019), Article ID 2489429, 3 pages
https://doi.org/10.1155/2019/2489429

Erratum

Erratum to “An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity”

Chun-Bing Chen,1,2,3,4,5,6 Riichiro Abe,⁷ Ren-You Pan,1,2 Chuang-Wei Wang,1,2 Shuen-Iu Hung,⁸ Yi-Giien Tsai,9,10,11 and Wen-Hung Chung1,2,3,4,6,12

¹Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou, Keelung, Taiwan
²Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan
³Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan
⁴College of Medicine, Chang Gung University, Taoyuan, Taiwan
⁵Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan
⁶Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan
⁷Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⁸Department and Institute of Pharmacology, School of Medicine, Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan
⁹Division of Pediatric Allergy and Immunology, Changhua Christian Hospital, Changhua City, Taiwan
¹⁰School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
¹¹School of Medicine, Chung Shan Medical University, Taichung, Taiwan
¹²Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China

Correspondence should be addressed to Wen-Hung Chung; wenhungchung@yahoo.com

Received 19 September 2018; Accepted 23 September 2018; Published 31 January 2019

Copyright © 2019 Chun-Bing Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In the article titled “An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity” [1], the format of Table 1 was unclear. Additionally, “B38:01 SJS/TEN Spanish [231]” should belong to Phenytoin not Carbamazepine. The updated table is shown below.

Table 1: HLA association with various phenotypes of drug hypersensitivity in different populations.

Associated drug
HLA allele
Hypersensitivity reactions
Ethnicity
Reference

Aromatic anticonvulsants

Carbamazepine
B15:02
SJS/TEN
Han Chinese, Thai, Indian, Malaysian, Vietnam, Singapore, Hong Kong
[45, 82, 83, 226–230]

A31:01
DRESS
Han Chinese, European, Spanish
[86, 87, 231]

A31:01
DRESS/SJS/TEN
Northern European, Japanese, Korean
[88–90]

B15:11
SJS/TEN
Han Chinese, Japanese, Korean,
[89, 232, 233]

B59:01
SJS/TEN
Japanese
[234]

Oxcarbazepine
B15:02
SJS/TEN
Han Chinese, Thai
[81, 84]

Phenytoin
B15:02
SJS/TEN
Han Chinese, Thai
[81, 83]

B15:02, B13:01, B51:01
SJS/TEN
Han Chinese, Japanese, Malaysian
[91]

A33:03, B38:02, B51:01, B56:02, B58:01, C14:02
SJS/TEN
Thai
[235]

B51:01
DRESS
Thai
[235]

B15:13
DRESS/SJS/TEN
Malaysian
[236]

CYP2C93
DRESS/SJS/TEN
Han Chinese, Japanese, Malaysian
[91]

CYP2C93
SJS/TEN
Thai
[235]

Lamotrigine
B15:02
SJS/TEN
Han Chinese
[81, 85, 237]

B38, B58:01, A68:01, Cw07:18
SJS/TEN
European
[93, 238]

B38:01
SJS/TEN
Spanish
[231]

A31:01
SJS/TEN
Korean
[239]

A24:02
DRESS
Spanish
[231]

Allopurinol
B58:01
DRESS
Han Chinese, Thai, Japanese, Korean, European
[92–96]

Antiretroviral drugs

Abacavir
B57:01
HSS
European, African
[98, 99]

Nevirapine
DRB101:01
DRESS
Australian
[240]

B35:05
DRESS
Thai
[101]

B14:02, Cw08:01, Cw08:02
HSS
Sardinian, Japanese
[102, 241]

C04:01
DRESS/SJS/TEN
Malawian
[242]

Antibiotics

Beta-Lactam
DR9, DR14.1, DR17, DR4
Immediate type drug hypersensitivity
Chinese
[243]

DRA rs7192, DRA rs8084
Immediate type drug hypersensitivity
Spanish, Italian
[66]

Cotrimoxazole
B15:02, C06:02, C08:01
SJS/TEN
Thai
[244]

Dapsone
B13:01
HSS
Han Chinese
[105]

Sulfamethoxazole
B38:02
SJS/TEN
European
[93]

Sulfonamide
A29, B12, DR7
TEN
European
[245]

NSAIDs

Aspirin
DRB113:02, DRB106:09
Urticaria/angioedema
Korean
[74]

Aspirin and other NSAIDs
DRB111
Urticaria/angioedema and hypotension/laryngeal edema
Spanish
[246]

Aspirin and other NSAIDs
B44, Cw5
Chronic idiopathic urticaria
Italian
[75]

Oxicam NSAIDs
B73:01
SJS/TEN
European
[93]

Other drugs

Methazolamide
B59:01, CW01:02
SJS/TEN
Korean, Japanese
[108]

DRESS: drug reaction with eosinophilia and systemic symptoms; HSS: hypersensitivity syndrome; MPE: maculopapular exanthema; NSAIDs: nonsteroidal anti-inflammatory drugs; SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis.

References

C.-B. Chen, R. Abe, R.-Y. Pan et al., “An updated review of the molecular mechanisms in drug hypersensitivity,” Journal of Immunology Research, vol. 2018, Article ID 6431694, 22 pages, 2018.