Journal of Obesity
Volume 2016 (2016), Article ID 2361290, 2 pages
http://dx.doi.org/10.1155/2016/2361290

Corrigendum

Corrigendum to “Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation”

Ha Thi Ngo, Ragna Bogen Hetland, Unni Cecilie Nygaard, and Inger-Lise Steffensen

Department of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, 0403 Oslo, Norway

Received 2 December 2015; Accepted 12 January 2016

Copyright © 2016 Ha Thi Ngo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In the published paper “Genetic and Diet-Induced Obesity Increased Intestinal Tumorigenesis in the Double Mutant Mouse Model Multiple Intestinal Neoplasia X Obese via Disturbed Glucose Regulation and Inflammation” [1] we mistakenly wrote IL-1β instead of IL-6 in Tables  2 and 3. In addition, IL-6 was not included in the text below the tables stating that it was measured by flow cytometer as was TNFα. The corrected tables are presented here.

Table 2: Associations between various parameters for body weight and glucose, insulin and cytokine levels.

AUC bw
Terminal bw
 Terminal BMI

Terminal bw
0.91
<0.001

Terminal BMI
0.59
<0.001
0.62
<0.001

Glucose
0.46
<0.001
0.47
<0.001
0.57
<0.001

6 weeks

Glucose
0.33
<0.001
0.33
<0.001
0.43
<0.001

11 weeks

Insulin
0.34
<0.001
0.32
<0.001
0.48
<0.001

IL-6
0.00
n.s.
0.00
n.s.
0.01
n.s.

TNFα
0.20
0.021
0.23
0.013
0.07
n.s.

Associations between various parameters for body weight (independent variables) and glucose, insulin, and cytokine levels (dependent variables) were examined with simple linear regression (SigmaPlot 12.3, Systat Software Inc., San Jose, CA, USA). This was performed on pairs of end points from all mice from all experimental groups from which individual data could be paired. Body weight (bw) data were evaluated either as area under the curve from week 3 to week 11 (AUC bw), as terminal bw, or as terminal body mass index (BMI) at 11 weeks of age. Nonfasted blood glucose was measured at 6 and 11 weeks of age. Insulin was measured with ELISA, and IL-6 and TNF were measured with flow cytometer, all in plasma obtained at termination at 11 weeks. = coefficient of determination, n.s. = not statistically significant.

Table 3: Associations between body weight, glucose, insulin and cytokine levels and the number or diameter of small intestinal tumors.

Number of small intestinal tumors

Diameter of small intestinal tumors

Diameter of tumors
0.51
<0.001
No. of tumors
0.51
<0.001

AUC bw
0.11
<0.001
AUC bw
0.14
<0.001

Terminal bw
0.05
<0.001
Terminal bw
0.07
<0.001

Terminal BMI
0.08
<0.001
Terminal BMI
0.10
<0.001

Glucose
 0.12
 <0.001
Glucose
 0.09
 <0.001

6 weeks
6 weeks

Glucose
 0.18
 <0.001
Glucose
 0.08
 <0.001

11 weeks
11 weeks

Insulin
0.03
n.s.
Insulin
0.06
n.s.

IL-6
0.00
n.s.
IL-6
0.01
n.s.

TNFα
0.09
n.s.
TNFα
0.31
0.003

Associations between body weight parameters, glucose, insulin, and cytokine levels (independent variables) and the number or diameter of small intestinal tumors (dependent variables) were examined with simple linear regression (SigmaPlot 12.3, Systat Software Inc., San Jose, CA, USA). This was performed on pairs of end points from all mice from all experimental groups from which individual data could be paired. Number of small intestinal tumors is calculated as number of tumors in each mouse, and tumor diameter is calculated as mean of all tumors in each mouse. Body weight (bw) data were evaluated either as area under the curve from week 3 to week 11 (AUC bw), as terminal bw, or as terminal body mass index (BMI) at 11 weeks of age. Nonfasted blood glucose was measured at 6 and 11 weeks of age. Insulin was measured with ELISA, and IL-6 and TNF were measured with flow cytometer, all in plasma obtained at termination at 11 weeks. = coefficient of determination, n.s. = not statistically significant.

References

H. T. Ngo, R. B. Hetland, U. C. Nygaard, and I. Steffensen, “Genetic and diet-induced obesity increased intestinal tumorigenesis in the double mutant mouse model multiple intestinal neoplasia X obese via disturbed glucose regulation and inflammation,” Journal of Obesity, vol. 2015, Article ID 343479, 21 pages, 2015.