Mediators of Inflammation
Volume 2016 (2016), Article ID 3151986, 2 pages
http://dx.doi.org/10.1155/2016/3151986

Corrigendum

Corrigendum to “Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice”

Xiao-Wen Chen,¹ Xiao-Yan Du,¹ Yu-Xian Wang,² Jian-Cheng Wang,¹ Wen-Ting Liu,¹ Wen-Jing Chen,¹ Hong-Yu Li,¹ Fen-Fen Peng,¹ Zhao-Zhong Xu,³ Hong-Xin Niu,¹ and Hai-Bo Long¹

¹Department of Nephrology, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China
²Department of Gerontology, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China
³Department of Emergency, ZhuJiang Hospital, Southern Medical University, Guangzhou 510280, China

Received 8 June 2016; Accepted 15 August 2016

Copyright © 2016 Xiao-Wen Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In the article titled “Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice” [1], in Figure 3(c)(A), the value of ordinate should be narrowed down to 0.01 times that of the data presented. And in Figure 6(b), the abscissa p-65/p65 should be changed to p-p65/p65. The two corrected figures are presented here.

(a)

(b)

(c)

Figure 3: Irb alleviated diabetes-induced podocyte injury and the thickening of the GBM. (a) Representative fields of podocyte foot processes under TEM (scale bars: 2 μm; red arrow indicates podocyte foot process effacement). (b) Representative fields of nephrin, as labeled by immunohistochemical staining (scale bars: 50 μm). (c) Quantification of the GBM thickness (A) and immunohistochemical staining (B). The bars in panel (c) show the mean expression in arbitrary units (error bars, SD). compared with db/m; compared with db/db, -test.

(a)

(b)

Figure 6: Irb inhibited NF-κB pathway activation in db/db mice. (a) Representative immunoblot of p-IκBα, IκBα, p-p65, and p65 in the kidney. (b) Quantification of the immunoblot: the ratio between p-IκBα and IκBα and the ratio between p-p65 and p65 are presented. The bars in panel (b) show the mean expression in arbitrary units (error bars, SD). compared with db/m; compared with db/db, -test.

References

X.-W. Chen, X.-Y. Du, Y.-X. Wang et al., “Irbesartan ameliorates diabetic nephropathy by suppressing the RANKL-RANK-NF-κB pathway in type 2 diabetic db/db mice,” Mediators of Inflammation, vol. 2016, Article ID 1405924, 10 pages, 2016.