Stem Cells International
Volume 2019 (2019), Article ID 7274057, 97 pages
https://doi.org/10.1155/2019/7274057

Research Article

A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Primary Cultured Cells and Subcultured Cells Using Mouse Adipose-Derived Mesenchymal Stem Cells

Yoshiki Nakashima,¹ Saifun Nahar,² Chika Miyagi-Shiohira,¹ Takao Kinjo,³ Naoya Kobayashi,⁴ Issei Saitoh,⁵ Masami Watanabe,⁶ Jiro Fujita,² and Hirofumi Noguchi¹

¹Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
²Department of Infectious, Respiratory, and Digestive Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
³Department of Basic Laboratory Sciences, School of Health Sciences in Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan
⁴Okayama Saidaiji Hospital, Okayama 704-8192, Japan
⁵Division of Pediatric Dentistry, Graduate School of Medical and Dental Science, Niigata University, Niigata 951-8514, Japan
⁶Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan

Correspondence should be addressed to Hirofumi Noguchi; noguchih@med.u-ryukyu.ac.jp

Received 23 April 2018; Revised 27 September 2018; Accepted 17 October 2018; Published 10 January 2019

Academic Editor: Katia Mareschi

Copyright © 2019 Yoshiki Nakashima et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Adipose-derived mesenchymal stem cells (MSC-ATs) are representative cell sources for cell therapy. However, how cell stress resulting from passage influences the MSC-AT protein expression has been unclear. In this study, a protein expression analysis was performed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) using mouse primary cultured cells (P0) and cells passaged three times (P3) as samples. A total of 256 proteins were classified as cellular process-related proteins, while 179 were classified as metabolic process-related proteins in P0. These were considered to be adaptive responses of the cells to an in vitro environment. However, seven proteins of growth were identified (Csf1, App, Adam15, Alcam, Tbl1xr1, Ninj1, and Sbds) in P0. In addition, four proteins of antioxidant activity were also identified (Srxn1, Txndc17, Fam213b, and Apoe) in P0. We identified 1139 proteins expressed in both P0 and P3 cells that had their expression decreased to 69.4% in P3 cells compared with P0 cells, but 1139 proteins are very likely proteins that are derived from MSC-AT. The function of MSC-ATs was maintained after three passages. However, the LC-MS/MS analysis data showed that the protein expression was degraded after three passages. MSC-ATs retained about 70% of their protein expression ability in P3 cells.

1. Introduction

Mesenchymal stromal stem cells (MSCs) are considered to have the ability to differentiate into mesenchymal cells, such as osteoblasts, adipocytes, muscle cells, and chondrocytes [1, 2]. These cells are also expected to have an immunosuppressive effect and are regarded as promising cellular therapeutic agents for immunological diseases resistant to treatment. MSCs have been established from various tissues (umbilical cord blood, placenta, adipose tissue, etc.), among which adipose tissue contains a particularly large amount of cells.

Clinical research and treatment using adipose-derived mesenchymal stem cells (MSC-ATs) [3] is already underway in many medical institutions around the world [4]. The clinical practical application of islet cell transplantation therapy was reported in 2000 in the Edmonton protocol [5] and many subsequent papers [6-10]. The technology of islet transplantation is thought to be useful for the processing of therapeutic cells using MSC-ATs. We recently reported that the University of Wisconsin (UW) [11] organ preservation solution has a better cell survival/proliferation ability than Hank’s balanced salt solution (HBSS) [12]. There is a possibility that the adipose tissue collected through the patient’s skin may be infected with skin bacteria. One method of sterilizing tissues collected from a living body involves immersing and storing such tissue for 16 h using HBSS [13], which also contains antibiotics. After such storage, MSC-ATs can be isolated from adipose tissue. In addition, adipose tissue collected from a patient can be transported to a remote location.

It was recently reported that the stress of long-term culture of cells in vitro also occurs in stem cells, such as induced pluripotent stem (iPS) cells, causing DNA damage and cellular carcinogenesis [14]. Some researchers recommend reducing the number of passages of MSC-ATs to maintain the quality of primary cultured cells. However, MSC-ATs of primary cultured cells are reportedly contaminated with various types of cells, such as blood cells, through the process of cell isolation. This is because the stromal vascular fraction (SVF) [15] obtained when collecting MSC-ATs using centrifugation contains many kinds of cells (e.g., adipocytes, fibroblasts, smooth muscle cells, endothelial cells, blood cells, endothelial progenitor cells, preadipocytes, vascular progenitors, hematopoietic progenitors, and hematopoietic stem cells) [16, 17]. For MSC-ATs isolated from adipocytes collected from patients, the number of cells can be increased by increasing the number of passages. Because this processing can be done outside the body, the patient can thus obtain many of her/his own cells after undergoing only one procedure of fat collection surgery. However, it is also important to maintain the quality of the cells. Therefore, researchers and clinicians have fervently discussed how many passaging operations of clinical MSC-ATs should be performed.

With liquid chromatography (or high-performance liquid chromatography (HPLC)) with tandem mass spectrometry (LC-MS/MS), the components to be analyzed are separated by a liquid chromatograph (LC) and ionized via a dedicated interface (ion source) and the generated ions are then separated by MS. LC-MS/MS is an analytical technique that dissociates and fragments mass ions and detects them with MS [18]. Recently, an online LC-MS/MS system for quantitative proteomics based on data-dependent protein IDs and shotgun-based quantitative proteomics methods was developed [19-23] by connecting the measuring equipment for a protein analysis to a computer and linking to an online protein database. In this way, a comprehensive protein expression analysis can be performed by checking the peptide sequence data of the protein contained in the sample.

A comprehensive expression analysis of the protein expressed by the cell is important for accurately understanding the mechanism underlying the effect of cell therapy accompanying the administration of the culture supernatant of cells and the cells themselves. The present study was performed to identify the functional protein components in mouse MSC-ATs of primary cultured cells (P0) and mMSC-ATs passaged three times (P3) using LC-MS/MS. The proteins specifically contained in primary cultured cells were identified as those expressed only in the SVF derived from AT. By examining the proteins expressed in both P0 and P3 cells, we can identify the proteins expressed by MSC-ATs. Determining the protein component of MSC-ATs that exerts a therapeutic effect is expected to be useful for cell therapy in the future.

2. Materials and Methods

2.1. Reagents

Fetal bovine serum (FBS) was obtained from Biowest (Nuaille, France). DMEM (high glucose) with L-glutamine, phenol red, and sodium pyruvate was obtained from FUJIFILM Wako Pure Chemical Corporation (Osaka, Japan). Plastic dishes were obtained from TPP (Trasadingen, Switzerland). All other materials used were of the highest commercial grade.

2.2. Animal Care

All experimental protocols were in accordance with the guidelines for the care and use of laboratory animals set by Research Laboratory Center, Faculty of Medicine, and the Institute for Animal Experiments, Faculty of Medicine, University of the Ryukyus (Okinawa, Japan). The experimental protocol was approved by the Committee on Animal Experiments of University of the Ryukyus (permit number: A2017101). C57BL/6 male mice (8 weeks of age; Japan SLC, Shizuoka, Japan) were maintained under controlled temperature (23 ± 2°C) and light conditions (lights on from 08:30 to 20:30). Animals were fed standard rodent chow pellets with ad libitum access to water. All efforts were made to minimize the suffering of the animals.

2.3. Isolation of MSC-ATs from Mouse via the Inguinal Pad Fat

AT was obtained from the inguinal pad fat of three 8-week-old mice. The method of isolating MSC-ATs from AT was in accordance with the AT-derived stem cell product standard document (RMRC-A 01: 2015) of Ryukyus Regenerative Medicine Research Center. In brief, these ATs were stored in cold HBSS and washed vigorously using HBSS three times before starting digestion. Next, the tissues were cut into small fragments with a scalpel for enzymatic digestion (2 mg collagenase type IV/ml; HBSS) in 50 ml tubes (rotation speed: 20 × 37°C × 60 min) using the shaker (BioShaker BR-42FM; TAITEC, Saitama, Japan). These tubes were then centrifuged (800) for 5 minutes. The SVF [24] containing various kinds of cells, including MSC-ATs, was confirmed at the bottom of the tube after centrifugation. The MSC-ATS were collected as a cell pellet and then washed with fresh DMEM containing 10% FBS to remove the enzyme after the digestion. The digested tissue was then incubated in a T25 flask.

All of the mouse studies were approved by the Institutional Animal Care and Use Committee of University of the Ryukyus.

2.4. Preparation of mMSC-ATs

Mouse MSC-ATs were cultured (37°C, 5% CO₂) in an uncoated T25 flask (TPP 90026). The passage of cells was performed every 3 to 4 days after reaching 80% confluence following sowing. The cells were then washed with PBS (calcium, magnesium-free), and mouse MSC-ATs were dissociated using a dissociation solution (Trypsin/EDTA (Lonza CC-3232)). Subculturing was carried out by plating on an uncoated T25 flask. DMEM containing 10% FBS was used for the culture medium.

2.5. Flow Cytometry

Cell flow cytometry was performed as described previously [25], using specific antibodies for CD34, CD 44, CD45, and CD90.2.

2.6. Cell Differentiation

Adipogenic and osteogenic differentiations were performed as described previously [25].

2.7. Protein Identification by a Nano-LC-MS/MS Analysis

We used an EzRIPA Lysis kit (ATTO Corporation, Tokyo, Japan) for cell lysis according to the manufacturer’s instructions. A protein solution of 4493 μg/ml (P0) and 3105 μg/ml (P3) was obtained from mADSCs, and 6.0 μg protein was used for sample preparation. Finally, 0.4 μg of protein was used for nano-LC-MS/MS. The comprehensive expression analysis of proteins using LC-MS/MS and data analyses were performed according to the method reported previously [25].

3. Results and Discussion

The application of cell therapy in regenerative medicine is expected to be useful for the treatment of many kinds of diseases. For example, MSC-ATs, which can be collected from AT, have been applied to the treatment of a wide range of diseases in light of the low invasiveness compared with surgery. It is generally recognized that MSC-ATs are stable in quality from P0 cells to P5 cells [26]. As such, many manuals of commercially available MSC-ATs state that the quality is guaranteed for five passages. It was reported that multiple passaging processes reduce both the cell proliferative activity and the cell surface marker expression [27] and induce chromosome abnormalities [15]. In addition, increasing the number of passages also increases the risk of microbial infection of cells. Therefore, the general perception among clinical researchers dealing with therapeutic cells is that MSC-ATs are only useful as therapeutic cells within the first five passages [28].

However, it is easy to imagine that preparing cells collected from a living organism without subculturing may enable the production of therapeutic cells with new and special functions. Therefore, clinicians may try using MSC-ATs isolated from AT without any culturing or P0 MSC-ATs. Close attention must be paid in such cases, as immune rejection can be caused when using therapeutic cells not only for autologous transplantation but also other transplantations as well.

3.1. The Characteristics and Cell Quality of mMSC-ATs (P0)

mMSC-ATs were cultured to 80% confluence using DMEM containing 10% FBS after isolation from AT. The whole medium was exchanged every two days. Microscopy was performed to confirm the absence of abnormalities with regard to the mMSC-AT (P0) size and shape and the culture state (Figure 1(a), left panel). Flow cytometry was performed using markers of mMSC-ATs (CD44, CD90.2), hematopoietic stem cells (CD34), and leukocytes (CD45). CD44 and CD90.2 were expressed in mMSC-ATs, while CD34 and CD45 were not detected (Figure 1(a), right panels). We induced differentiation into adipocytes (Figure 1(b), left panel) and osteoblasts (Figure 1(b), right panel) using mMSC-ATs. Mature adipocytes were stained with Oil Red O, and mature osteoblasts were stained with Alizarin Red S.

(a)

(b)

(c)

(d)

Figure 1: The phenotype and differentiation potential of mMSC-ATs in culture. The morphological appearance of mMSC-ATs (P0) ((a) left panel; scale bar = 800 μm). The results of flow cytometry of the cell surface markers of mMSC-ATs (P0) ((a) right panels). Representative images of adipocyte ((b) left panel; scale bar = 100 μm) and osteocyte differentiation ((b) right panel; scale bar = 200 μm) of mouse MSC-ATs (P0) cultured in differentiation medium. The morphological appearance of mMSC-ATs (P3) ((c) left panel; scale bar = 800 μm). The results of flow cytometry of the cell surface markers of mMSC-ATs (P3) ((c) right panels). Representative images of adipocyte ((d) left panel; scale bar = 100 μm) and osteocyte differentiation ((d) right panel; scale bar = 200 μm) of mouse MSC-ATs (P3) cultured in differentiation medium.

3.2. The Characteristics and Cell Quality of mMSC-ATs (P3)

mMSC-ATs were cultured to 80% confluence using DMEM containing 10% FBS after isolation from adipose tissue. The whole medium was exchanged every two days. The passage of cells was performed every 3 to 4 days after reaching 80% confluence. Microscopy was performed to confirm the absence of abnormalities with regard to the mMSC-AT (P3) size and shape and the culture state (Figure 1(c), left panel). Flow cytometry was performed using markers of mMSC-ATs (CD44, CD90.2), hematopoietic stem cells (CD34) and leukocytes (CD45). CD44 and CD90.2 were expressed in mMSC-ATs while CD34 and CD45 were not detected (Figure 1(c), right panels). We induced differentiation into adipocytes (Figure 1(d), left panel) and osteoblasts (Figure 1(d), right panel) using mMSC-ATs. Mature adipocytes were stained with Oil Red O, and mature osteoblasts were stained with Alizarin Red S.

A proteome analysis using LC-MS/MS provided evidence supporting the safe application of cell therapy with MSCs and supplied information on the potential application of MSCs in various treatments. A protein analysis indicates the protein components present in the cell component. In this study, mMSC-ATs were used, but when human MSC-ATs are used, this analysis will show the protein components that should be administered to patients.

3.3. A Comprehensive Protein Expression Analysis of mMSC-ATs (P0 and P3)

We performed mMSC-AT isolation according to a protocol similar to that used in clinical studies at the University of the Ryukyus, and isolated mMSC-ATs were subjected to LC-MS/MS after 0 or 3 passages. The presence of a large amount of albumin in the medium reduces the accuracy in protein analyses. Therefore, the protein extracts obtained from the cells after washing with phosphate-buffered saline (PBS) were used in this study.

There were 1785 types of proteins identified from the mMSC-AT (P0) samples (Table 1) and 1825 types of proteins identified from the mMSC-AT (P3) samples (Table 2). Among the 1785 types of proteins in mouse P0 cells, there were 336 types of proteins unique to the primary cultured cells (group P0). A total of 1449 types of proteins in mouse P0 cells were also identified in mouse P3 cells (group P0&P3). Among the 1825 types of proteins in mouse P3 cells, there were 376 types of proteins unique to the cells passaged 3 times (group P3) (Figure 2). Therefore, the 336 types of proteins whose expression was eliminated by passage were deemed likely to have been derived from the different types of cells contained in the SVF.

Table 1: Identification of endogenous proteins contained in mMSC-AT_P0 (primary cultured cells).

UniProt/Swiss-Prot ID
Description
Protein scorea
Protein mass (kDa)
pIb
Num. of matchesc
Num. of significant matchesd
Num. of sequencese
Num. of significant sequencesf
Num. of unique sequencesg
Sequence coverageh
emPAIi

FLNA_MOUSE
Filamin-A
2702
281046
5.68
220
138
87
56
81
0.54
1.34

FLNB_MOUSE
Filamin-B
1877
277651
5.46
164
94
81
51
73
0.52
1.23

FLNC_MOUSE
Filamin-C
1471
290937
5.63
115
68
57
33
11
0.39
0.68

MYH9_MOUSE
Myosin-9
2689
226232
5.54
232
114
116
57
100
0.64
2.27

TLN1_MOUSE
Talin-1
2390
269653
5.84
147
98
72
53
52
0.49
1.39

IQGA1_MOUSE
Ras GTPase-activating-like protein IQGAP1
1740
188624
6.07
97
56
53
33
53
0.47
1.13

CLH1_MOUSE
Clathrin heavy chain 1
1668
191435
5.48
114
80
64
49
64
0.6
2.26

CH60_MOUSE
60 kDa heat shock protein, mitochondrial
1558
60917
5.91
75
58
29
22
29
0.66
5.35

DYHC1_MOUSE
Cytoplasmic dynein 1 heavy chain 1
1460
531710
6.03
121
67
85
48
85
0.3
0.47

ACTN1_MOUSE
Alpha-actinin-1
1455
103004
5.23
99
55
44
29
26
0.63
2.67

ACTN4_MOUSE
Alpha-actinin-4
914
104911
5.25
76
36
39
23
21
0.56
1.5

HSP7C_MOUSE
Heat shock cognate 71 kDa protein
1427
70827
5.37
147
72
34
26
27
0.72
4.53

GRP78_MOUSE
78 kDa glucose-regulated protein
1101
72377
5.07
114
54
35
23
32
0.64
2.77

GRP75_MOUSE
Stress-70 protein, mitochondrial
851
73416
5.81
65
36
22
17
21
0.46
1.79

HS71A_MOUSE
Heat shock 70 kDa protein 1A
246
70036
5.53
34
13
12
7
8
0.34
0.52

NSF_MOUSE
Vesicle-fusing ATPase
98
82561
6.52
8
4
7
4
7
0.15
0.22

TBB6_MOUSE
Tubulin beta-6 chain
517
50058
4.8
59
35
24
17
10
0.79
3.86

VIME_MOUSE
Vimentin
1321
53655
5.06
170
69
45
30
45
0.76
9.3

ENPL_MOUSE
Endoplasmin
1314
92418
4.74
108
60
44
32
20
0.58
4.09

HS90A_MOUSE
Heat shock protein HSP 90-alpha
1047
84735
4.93
93
47
38
22
25
0.56
2.27

ENOA_MOUSE
Alpha-enolase
1304
47111
6.37
95
58
23
17
23
0.74
6

FAS_MOUSE
Fatty acid synthase
1264
272257
6.13
89
59
61
44
61
0.45
1.03

G3P_MOUSE
Glyceraldehyde-3-phosphate dehydrogenase
1238
35787
8.44
94
50
19
13
15
0.76
9.22

KPYM_MOUSE
Pyruvate kinase PKM
1232
57808
7.18
98
58
37
30
12
0.74
13.41

ACTBL_MOUSE
Beta-actin-like protein 2
361
41977
5.3
52
22
13
5
4
0.51
1.44

TSP1_MOUSE
Thrombospondin-1
1160
129564
4.72
117
62
35
17
34
0.36
0.91

ATPA_MOUSE
ATP synthase subunit alpha, mitochondrial
1118
59716
9.22
64
44
24
18
16
0.58
3.34

SPB6_MOUSE
Serpin B6
1096
42571
5.53
49
36
21
14
21
0.71
4.79

ILEUA_MOUSE
Leukocyte elastase inhibitor A
99
42548
5.85
4
4
3
3
3
0.11
0.34

GDN_MOUSE
Glia-derived nexin
84
44179
9.85
6
4
5
4
5
0.16
0.46

FINC_MOUSE
Fibronectin
1089
272368
5.39
97
52
57
34
57
0.4
0.69

EF2_MOUSE
Elongation factor 2
1085
95253
6.41
91
53
47
28
46
0.66
2.42

UBA1_MOUSE
Ubiquitin-like modifier-activating enzyme 1
1077
117734
5.43
55
39
26
19
26
0.45
1.11

RINI_MOUSE
Ribonuclease inhibitor
991
49784
4.69
48
34
23
17
19
0.81
3.14

PDIA1_MOUSE
Protein disulfide-isomerase
965
57023
4.77
91
48
34
21
34
0.62
3.99

ATPB_MOUSE
ATP synthase subunit beta, mitochondrial
853
56265
5.19
65
39
28
22
26
0.81
4.5

TCPA_MOUSE
T-complex protein 1 subunit alpha
833
60411
5.82
44
25
23
12
23
0.64
2.02

1433Z_MOUSE
14-3-3 protein zeta/delta
831
27754
4.73
46
29
15
11
12
0.6
4.16

1433B_MOUSE
14-3-3 protein beta/alpha
539
28069
4.77
28
19
13
10
3
0.63
3.37

CO1A1_MOUSE
Collagen alpha-1(I) chain
825
137948
5.65
141
65
42
24
25
0.53
1.27

HSP74_MOUSE
Heat shock 70 kDa protein 4
817
94073
5.15
56
29
26
18
25
0.46
1.22

HS105_MOUSE
Heat shock protein 105 kDa
118
96346
5.39
14
6
12
5
11
0.25
0.24

LRP1_MOUSE
Prolow-density lipoprotein receptor-related protein 1
815
504411
5.14
75
39
54
26
54
0.22
0.24

WDR1_MOUSE
WD repeat-containing protein 1
796
66365
6.11
35
23
18
12
18
0.57
1.13

LDHA_MOUSE
L-Lactate dehydrogenase A chain
752
36475
7.62
81
28
19
11
19
0.79
3.92

ANXA1_MOUSE
Annexin A1
750
38710
6.97
50
27
21
11
21
0.61
2.26

MOES_MOUSE
Moesin
737
67725
6.22
73
32
34
15
23
0.61
2.03

TKT_MOUSE
Transketolase
732
67588
7.23
53
32
26
16
26
0.69
2.04

SERPH_MOUSE
Serpin H1
731
46504
8.88
56
35
23
16
23
0.68
4.01

SC31A_MOUSE
Protein transport protein Sec31A
707
133486
6.3
30
23
15
13
15
0.27
0.55

ALDOA_MOUSE
Fructose-bisphosphate aldolase A
674
39331
8.31
56
33
23
15
23
0.83
5.04

VDAC1_MOUSE
Voltage-dependent anion-selective channel protein 1
667
32331
8.55
31
23
11
9
11
0.67
2.61

VDAC2_MOUSE
Voltage-dependent anion-selective channel protein 2
454
31713
7.44
25
19
10
8
10
0.54
1.84

RPN2_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 2
666
69020
5.54
34
24
19
16
19
0.52
1.63

ASSY_MOUSE
Argininosuccinate synthase
660
46555
8.36
54
25
24
12
22
0.75
2.5

SYAC_MOUSE
Alanine–tRNA ligase, cytoplasmic
658
106841
5.45
46
25
29
18
29
0.55
1.02

UGGG1_MOUSE
UDP-glucose:glycoprotein glucosyltransferase 1
656
176323
5.4
34
20
24
15
24
0.3
0.43

ANXA5_MOUSE
Annexin A5
647
35730
4.83
65
34
19
12
18
0.71
4.71

ANXA3_MOUSE
Annexin A3
313
36362
5.5
29
16
17
12
16
0.64
2.93

ANXA6_MOUSE
Annexin A6
196
75837
5.34
17
11
12
8
12
0.27
0.55

ANX11_MOUSE
Annexin A11
53
54045
7.53
4
3
3
2
3
0.11
0.17

CO1A2_MOUSE
Collagen alpha-2(I) chain
645
129478
9.27
61
38
29
17
29
0.44
0.85

6PGD_MOUSE
6-Phosphogluconate dehydrogenase, decarboxylating
642
53213
6.81
38
21
19
14
19
0.63
2

SPTN1_MOUSE
Spectrin alpha chain, nonerythrocytic 1
639
284422
5.2
61
37
45
25
45
0.32
0.45

AT1A1_MOUSE
Sodium/potassium-transporting ATPase subunit alpha-1
619
112910
5.3
47
26
25
15
25
0.34
0.74

GDIB_MOUSE
Rab GDP dissociation inhibitor beta
615
50505
5.93
40
22
18
10
13
0.58
1.48

GDIA_MOUSE
Rab GDP dissociation inhibitor alpha
274
50489
4.96
25
13
13
9
8
0.49
1.28

EF1G_MOUSE
Elongation factor 1-gamma
613
50029
6.31
43
29
21
14
21
0.67
2.48

TCPQ_MOUSE
T-complex protein 1 subunit theta
611
59518
5.44
35
19
20
12
20
0.53
1.32

MDHM_MOUSE
Malate dehydrogenase, mitochondrial
603
35589
8.93
39
27
16
11
16
0.58
3.55

PDIA4_MOUSE
Protein disulfide-isomerase A4
602
71938
5.16
50
29
21
13
21
0.45
1.39

CAP1_MOUSE
Adenylyl cyclase-associated protein 1
594
51532
7.16
58
28
24
14
24
0.73
2.1

IMB1_MOUSE
Importin subunit beta-1
584
97122
4.68
33
24
24
17
24
0.41
1.08

CAPG_MOUSE
Macrophage-capping protein
263
39216
6.73
16
8
6
5
1
0.3
0.7

ESTD_MOUSE
S-Formylglutathione hydrolase
576
31299
6.7
50
28
17
12
17
0.87
5.39

CAN2_MOUSE
Calpain-2 catalytic subunit
566
79822
4.86
37
28
23
20
20
0.58
2

VATB2_MOUSE
V-type proton ATPase subunit B, brain isoform
562
56515
5.57
40
27
20
14
20
0.69
2.03

VPS35_MOUSE
Vacuolar protein sorting-associated protein 35
561
91655
5.28
32
21
16
10
16
0.3
0.58

LYAG_MOUSE
Lysosomal alpha-glucosidase
561
106180
5.53
34
26
20
16
20
0.37
0.88

ACLY_MOUSE
ATP-citrate synthase
559
119651
7.13
34
23
27
18
27
0.39
0.94

FPPS_MOUSE
Farnesyl pyrophosphate synthase
554
40556
5.49
31
18
17
10
17
0.61
1.79

COPG1_MOUSE
Coatomer subunit gamma-1
553
97450
5.23
35
22
24
18
20
0.46
1.16

IDHC_MOUSE
Isocitrate dehydrogenase [NADP] cytoplasmic
552
46644
6.73
35
25
17
10
16
0.57
1.92

VIGLN_MOUSE
Vigilin
550
141655
6.43
40
24
27
15
27
0.34
0.56

P4HA1_MOUSE
Prolyl 4-hydroxylase subunit alpha-1
546
60872
5.62
33
18
17
12
17
0.5
1.44

CATB_MOUSE
Cathepsin B
542
37256
5.57
39
24
13
11
13
0.6
3.26

VINC_MOUSE
Vinculin
520
116644
5.77
53
24
33
19
33
0.41
0.98

CNDP2_MOUSE
Cytosolic nonspecific dipeptidase
516
52734
5.43
41
23
20
15
20
0.67
2.27

SEPT2_MOUSE
Septin-2
515
41499
6.1
22
16
14
9
14
0.56
1.46

DPYL2_MOUSE
Dihydropyrimidinase-related protein 2
509
62239
5.95
43
25
25
15
22
0.73
1.73

DPYL3_MOUSE
Dihydropyrimidinase-related protein 3
203
61897
6.04
16
9
8
4
5
0.21
0.31

TAGL2_MOUSE
Transgelin-2
509
22381
8.39
42
28
14
11
14
0.8
8.1

TCPH_MOUSE
T-complex protein 1 subunit eta
501
59614
7.95
34
22
18
15
18
0.53
2.06

FRIL1_MOUSE
Ferritin light chain 1
500
20790
5.66
18
15
6
4
6
0.49
1.7

NCPR_MOUSE
NADPH–cytochrome P450 reductase
499
76995
5.34
19
15
12
8
12
0.33
0.54

TCPZ_MOUSE
T-complex protein 1 subunit zeta
491
57968
6.63
30
18
19
12
19
0.55
1.37

VATA_MOUSE
V-type proton ATPase catalytic subunit A
481
68283
5.42
43
23
27
14
27
0.6
1.35

XDH_MOUSE
Xanthine dehydrogenase/oxidase
475
146468
7.62
28
23
16
14
16
0.24
0.54

PDC6I_MOUSE
Programmed cell death 6-interacting protein
475
95964
6.15
25
17
17
12
17
0.35
0.76

CAND1_MOUSE
Cullin-associated NEDD8-dissociated protein 1
473
136245
5.52
26
19
20
14
20
0.33
0.64

COF1_MOUSE
Cofilin-1
473
18548
8.22
30
18
11
9
9
0.61
6.37

COF2_MOUSE
Cofilin-2
182
18698
7.66
20
10
6
4
4
0.49
1.42

LG3BP_MOUSE
Galectin-3-binding protein
471
64450
5
17
12
10
6
9
0.3
0.47

VAT1_MOUSE
Synaptic vesicle membrane protein VAT-1 homolog
471
43069
5.95
44
25
21
14
21
0.65
3.69

TCPD_MOUSE
T-complex protein 1 subunit delta
467
58030
8.24
35
17
20
9
20
0.59
0.91

AMPN_MOUSE
Aminopeptidase N
465
109582
5.62
26
21
17
16
17
0.3
0.84

PPIA_MOUSE
Peptidyl-prolyl cis-trans isomerase A
465
17960
7.74
33
21
11
8
11
0.7
11.36

MDHC_MOUSE
Malate dehydrogenase, cytoplasmic
464
36488
6.16
21
14
10
6
10
0.52
1.22

G6PI_MOUSE
Glucose-6-phosphate isomerase
462
62727
8.14
29
18
15
10
8
0.4
1.08

PDIA3_MOUSE
Protein disulfide-isomerase A3
449
56643
5.88
115
29
32
16
32
0.64
2.77

THIO_MOUSE
Thioredoxin
445
11668
4.8
24
16
7
6
7
0.78
7.1

RLA0_MOUSE
60S acidic ribosomal protein P0
441
34195
5.91
30
21
14
10
14
0.56
2.8

ESYT1_MOUSE
Extended synaptotagmin-1
437
121478
5.63
20
17
13
11
13
0.22
0.46

2AAA_MOUSE
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
437
65281
5
20
14
17
12
17
0.46
1.15

PTBP1_MOUSE
Polypyrimidine tract-binding protein 1
437
56443
8.47
22
11
8
5
8
0.36
0.68

AT2A2_MOUSE
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
436
114784
5.23
33
20
20
12
20
0.32
0.55

SPTB2_MOUSE
Spectrin beta chain, nonerythrocytic 1
429
274052
5.4
52
21
39
20
39
0.25
0.38

SCOT1_MOUSE
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
428
55953
8.73
29
20
14
12
14
0.5
1.63

CALR_MOUSE
Calreticulin
419
47965
4.33
43
26
19
11
19
0.6
1.84

CKAP4_MOUSE
Cytoskeleton-associated protein 4
418
63654
5.46
48
27
25
13
25
0.54
1.86

MYOF_MOUSE
Myoferlin
417
233177
5.83
44
17
30
12
30
0.24
0.24

GSTP1_MOUSE
Glutathione S-transferase P 1
417
23594
7.68
21
14
9
7
9
0.58
3.82

PLEC_MOUSE
Plectin
416
533861
5.74
66
21
52
16
52
0.18
0.13

TCPB_MOUSE
T-complex protein 1 subunit beta
414
57441
5.97
27
15
20
13
20
0.56
1.57

KAD1_MOUSE
Adenylate kinase isoenzyme 1
410
21526
5.67
15
13
9
8
6
0.64
3.63

PRDX6_MOUSE
Peroxiredoxin-6
405
24855
5.71
36
18
16
11
16
0.75
5.23

RL9_MOUSE
60S ribosomal protein L9
401
21868
9.96
12
10
5
4
5
0.48
1.13

UGDH_MOUSE
UDP-glucose 6-dehydrogenase
398
54797
7.49
33
18
22
14
22
0.66
1.9

CATD_MOUSE
Cathepsin D
389
44925
6.71
35
21
15
9
15
0.55
2.33

NIBL1_MOUSE
Niban-like protein 1
388
84765
5.65
23
15
18
13
18
0.36
0.9

TXND5_MOUSE
Thioredoxin domain-containing protein 5
386
46386
5.51
17
14
8
5
8
0.32
0.57

TSP2_MOUSE
Thrombospondin-2
385
129798
4.61
44
19
22
10
21
0.28
0.38

MAOX_MOUSE
NADP-dependent malic enzyme
384
63913
7.16
15
11
14
10
14
0.49
0.92

ARF4_MOUSE
ADP-ribosylation factor 4
382
20384
6.59
23
15
11
8
5
0.83
6.52

COPB2_MOUSE
Coatomer subunit beta
381
102384
5.17
33
20
24
15
24
0.43
0.85

PRDX1_MOUSE
Peroxiredoxin-1
379
22162
8.26
87
35
20
14
19
0.8
15.25

PRDX2_MOUSE
Peroxiredoxin-2
316
21765
5.2
16
11
8
7
8
0.45
2.77

PRDX4_MOUSE
Peroxiredoxin-4
152
31033
6.67
18
7
11
5
10
0.52
0.95

PLSL_MOUSE
Plastin-2
378
70105
5.2
35
21
22
13
20
0.48
1.17

GPNMB_MOUSE
Transmembrane glycoprotein NMB
378
63635
7.55
27
16
10
5
10
0.22
0.48

GELS_MOUSE
Gelsolin
371
85888
5.83
32
21
17
13
17
0.45
0.98

THIC_MOUSE
Acetyl-CoA acetyltransferase, cytosolic
371
41271
7.16
20
12
12
8
12
0.59
1.24

ECHA_MOUSE
Trifunctional enzyme subunit alpha, mitochondrial
371
82617
9.24
24
16
16
10
16
0.44
0.66

MYO1C_MOUSE
Unconventional myosin-Ic
370
121868
9.41
34
17
29
14
29
0.4
0.62

PDIA6_MOUSE
Protein disulfide-isomerase A6
369
48070
5
29
22
14
12
14
0.48
1.83

EIF3L_MOUSE
Eukaryotic translation initiation factor 3 subunit L
368
66570
6.01
16
11
7
5
7
0.21
0.37

MVP_MOUSE
Major vault protein
365
95865
5.43
30
16
17
10
17
0.35
0.55

HYOU1_MOUSE
Hypoxia-upregulated protein 1
362
111112
5.12
18
10
15
8
15
0.27
0.35

FABP5_MOUSE
Fatty acid-binding protein, epidermal
361
15127
6.14
35
19
8
6
8
0.66
7.75

IPO5_MOUSE
Importin-5
358
123511
4.82
42
28
25
19
25
0.44
1.11

TCPE_MOUSE
T-complex protein 1 subunit epsilon
356
59586
5.72
27
17
17
10
17
0.45
1.16

OST48_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 48 kDa subunit
355
48997
5.52
21
13
11
5
11
0.38
0.81

SYRC_MOUSE
Arginine–tRNA ligase, cytoplasmic
354
75625
7.48
19
11
14
7
14
0.31
0.56

NB5R3_MOUSE
NADH-cytochrome b5 reductase 3
354
34106
8.55
26
18
12
10
12
0.68
2.82

NDKB_MOUSE
Nucleoside diphosphate kinase B
353
17352
6.97
30
14
10
4
6
0.74
3.15

NDKA_MOUSE
Nucleoside diphosphate kinase A
171
17197
6.84
22
11
7
5
3
0.59
4.32

CO5A1_MOUSE
Collagen alpha-1(V) chain
351
183564
4.86
13
11
8
6
8
0.1
0.15

RLA2_MOUSE
60S acidic ribosomal protein P2
348
11644
4.42
13
9
5
5
5
0.7
4.72

AK1A1_MOUSE
Alcohol dehydrogenase [NADP(+)]
344
36564
6.9
23
16
16
11
16
0.64
2.92

ALDR_MOUSE
Aldose reductase
114
35709
6.71
14
6
7
4
7
0.26
0.59

PCBP2_MOUSE
Poly(rC)-binding protein 2
343
38197
6.33
32
17
12
8
2
0.55
1.66

NEDD4_MOUSE
E3 ubiquitin-protein ligase NEDD4
343
102642
5.12
29
17
18
11
18
0.33
0.57

UAP1L_MOUSE
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
342
56578
5.27
28
15
19
11
17
0.55
1.25

UAP1_MOUSE
UDP-N-acetylhexosamine pyrophosphorylase
87
58572
6.04
4
3
2
2
1
0.06
0.15

CLIC1_MOUSE
Chloride intracellular channel protein 1
342
26996
5.09
24
13
14
8
13
0.72
2.41

GSLG1_MOUSE
Golgi apparatus protein 1
342
133646
6.45
20
11
16
7
11
0.2
0.28

DNJC3_MOUSE
DnaJ homolog subfamily C member 3
341
57428
5.61
9
5
6
3
6
0.29
0.24

FSCN1_MOUSE
Fascin
340
54474
6.44
24
10
15
8
15
0.51
0.84

SODM_MOUSE
Superoxide dismutase [Mn], mitochondrial
340
24588
8.8
12
9
5
4
5
0.46
0.96

PROF1_MOUSE
Profilin-1
339
14948
8.46
65
22
11
7
11
0.78
10.68

MBB1A_MOUSE
Myb-binding protein 1A
339
151942
9.08
21
15
15
10
15
0.18
0.32

CISY_MOUSE
Citrate synthase, mitochondrial
338
51703
8.72
23
14
16
11
16
0.56
1.63

SAP_MOUSE
Prosaposin
338
61381
5.07
45
16
19
10
19
0.49
1.11

ADT1_MOUSE
ADP/ATP translocase 1
278
32883
9.73
25
9
16
7
9
0.61
1.42

CPNS1_MOUSE
Calpain small subunit 1
337
28445
5.41
14
9
7
5
7
0.41
1.07

UGPA_MOUSE
UTP–glucose-1-phosphate uridylyltransferase
335
56944
7.18
14
9
9
6
9
0.3
0.55

NACAM_MOUSE
Nascent polypeptide-associated complex subunit alpha, muscle-specific form
330
220364
9.39
20
12
8
3
8
0.06
0.06

DLDH_MOUSE
Dihydrolipoyl dehydrogenase, mitochondrial
329
54238
7.99
16
12
10
7
10
0.39
0.71

HNRPF_MOUSE
Heterogeneous nuclear ribonucleoprotein F
327
45701
5.31
17
10
10
6
8
0.42
0.73

OAT_MOUSE
Ornithine aminotransferase, mitochondrial
326
48324
6.19
25
14
9
6
9
0.4
0.68

DHB12_MOUSE
Very-long-chain 3-oxoacyl-CoA reductase
324
34719
9.55
18
13
12
9
12
0.56
1.93

DHE3_MOUSE
Glutamate dehydrogenase 1, mitochondrial
323
61298
8.05
36
16
16
9
16
0.44
0.85

CATS_MOUSE
Cathepsin S
323
38449
6.51
18
10
12
7
12
0.53
1.13

ITB5_MOUSE
Integrin beta-5
322
87851
5.81
18
14
10
7
10
0.25
0.4

CATL1_MOUSE
Cathepsin L1
321
37523
6.37
13
10
8
6
8
0.5
1.43

PSMD1_MOUSE
26S proteasome non-ATPase regulatory subunit 1
321
105663
5.25
20
12
15
10
15
0.29
0.49

RPN1_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1
320
68486
6.02
32
19
19
11
19
0.45
0.96

LYOX_MOUSE
Protein-lysine 6-oxidase
319
46671
8.73
20
13
8
5
8
0.37
0.56

AOFA_MOUSE
Amine oxidase [flavin-containing] A
319
59564
7.9
19
14
12
7
12
0.39
0.63

PSD12_MOUSE
26S proteasome non-ATPase regulatory subunit 12
315
52861
6.66
22
12
15
7
15
0.43
0.74

COCA1_MOUSE
Collagen alpha-1(XII) chain
315
340004
5.47
39
19
24
14
24
0.15
0.19

ALDH2_MOUSE
Aldehyde dehydrogenase, mitochondrial
315
56502
7.53
39
20
19
14
19
0.62
2.03

PP1A_MOUSE
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
314
37516
5.94
15
12
10
7
10
0.37
1.17

TPIS_MOUSE
Triosephosphate isomerase
312
32171
5.56
36
14
14
9
14
0.64
2.63

GSTM1_MOUSE
Glutathione S-transferase Mu 1
311
25953
7.71
32
13
12
6
9
0.61
2.05

GSTM2_MOUSE
Glutathione S-transferase Mu 2
195
25700
6.9
17
8
11
6
8
0.6
1.62

MPRI_MOUSE
Cation-independent mannose-6-phosphate receptor
309
273639
5.47
30
18
23
16
23
0.18
0.28

CALX_MOUSE
Calnexin
307
67236
4.5
23
15
16
9
16
0.37
0.86

EIF3D_MOUSE
Eukaryotic translation initiation factor 3 subunit D
305
63948
5.79
11
8
7
5
7
0.25
0.39

TPM4_MOUSE
Tropomyosin alpha-4 chain
203
28450
4.65
21
9
11
7
10
0.46
1.77

CATZ_MOUSE
Cathepsin Z
303
33974
6.13
11
9
4
4
4
0.26
0.63

GNAI2_MOUSE
Guanine nucleotide-binding protein G(i) subunit alpha-2
255
40463
5.28
19
9
11
6
5
0.38
0.85

STOM_MOUSE
Erythrocyte band 7 integral membrane protein
300
31355
6.45
18
10
7
5
7
0.38
0.94

ITB1_MOUSE
Integrin beta-1
300
88173
5.68
29
17
18
10
18
0.41
0.61

PSA7_MOUSE
Proteasome subunit alpha type-7
296
27838
8.59
15
6
8
4
8
0.48
0.81

KCRB_MOUSE
Creatine kinase B-type
295
42686
5.4
17
12
10
6
10
0.52
0.79

COPB_MOUSE
Coatomer subunit beta
295
106998
5.69
16
11
14
10
14
0.23
0.48

LEG1_MOUSE
Galectin-1
294
14856
5.32
28
14
9
6
9
0.75
8.03

ANXA2_MOUSE
Annexin A2
293
38652
7.55
24
19
14
11
14
0.49
2.27

XPO2_MOUSE
Exportin-2
289
110384
5.52
10
9
6
5
6
0.12
0.26

EF1D_MOUSE
Elongation factor 1-delta
289
31274
4.91
22
11
11
7
10
0.5
1.53

EF1B_MOUSE
Elongation factor 1-beta
205
24678
4.53
16
9
6
6
5
0.42
1.74

PAI1_MOUSE
Plasminogen activator inhibitor 1
288
45141
6.17
20
10
13
7
13
0.49
0.91

APT_MOUSE
Adenine phosphoribosyltransferase
287
19712
6.31
10
8
6
5
6
0.51
1.84

AKA12_MOUSE
A-kinase anchor protein 12
286
180586
4.39
36
13
22
8
22
0.26
0.2

IMA4_MOUSE
Importin subunit alpha-4
85
57737
4.8
7
4
5
3
2
0.22
0.24

SERA_MOUSE
D-3-Phosphoglycerate dehydrogenase
283
56549
6.12
21
14
14
9
14
0.34
0.94

SND1_MOUSE
Staphylococcal nuclease domain-containing protein 1
282
102025
7.08
25
19
12
10
12
0.26
0.57

ITA5_MOUSE
Integrin alpha-5
280
114971
5.65
23
14
13
9
13
0.2
0.44

RRBP1_MOUSE
Ribosome-binding protein 1
280
172776
9.35
42
16
28
9
28
0.24
0.24

PSB4_MOUSE
Proteasome subunit beta type-4
280
29097
5.47
9
5
7
3
7
0.45
0.53

NUCL_MOUSE
Nucleolin
278
76677
4.69
14
11
10
8
10
0.2
0.55

SFXN3_MOUSE
Sideroflexin-3
277
35384
9.58
12
7
7
3
7
0.4
0.42

ADK_MOUSE
Adenosine kinase
276
40123
5.84
12
11
7
6
7
0.35
0.86

HNRPU_MOUSE
Heterogeneous nuclear ribonucleoprotein U
275
87863
5.92
25
15
17
12
17
0.27
0.77

HXK3_MOUSE
Hexokinase-3
270
100037
5.63
20
12
13
7
13
0.26
0.34

PGM1_MOUSE
Phosphoglucomutase-1
270
61380
6.14
15
11
8
6
8
0.27
0.61

PSB2_MOUSE
Proteasome subunit beta type-2
269
22892
6.52
24
14
10
5
10
0.64
1.95

ICAL_MOUSE
Calpastatin
269
84871
5.37
10
7
5
4
5
0.15
0.22

CD81_MOUSE
CD81 antigen
268
25797
5.54
5
5
2
2
2
0.18
0.62

PPCE_MOUSE
Prolyl endopeptidase
267
80700
5.44
17
8
12
5
12
0.31
0.3

PEBP1_MOUSE
Phosphatidylethanolamine-binding protein 1
267
20817
5.19
16
11
9
7
9
0.78
2.99

MRC2_MOUSE
C-type mannose receptor 2
265
166968
5.65
18
11
14
8
14
0.19
0.22

AP2A2_MOUSE
AP-2 complex subunit alpha-2
264
103951
6.51
24
11
16
7
10
0.28
0.33

AP2A1_MOUSE
AP-2 complex subunit alpha-1
140
107596
6.63
18
7
17
6
11
0.31
0.26

DDB1_MOUSE
DNA damage-binding protein 1
262
126772
5.14
19
11
9
4
9
0.16
0.18

ITAV_MOUSE
Integrin alpha-V
262
115287
5.41
28
10
15
5
15
0.18
0.2

CH10_MOUSE
10 kDa heat shock protein, mitochondrial
260
10956
7.93
18
10
5
2
5
0.52
1.09

COMT_MOUSE
Catechol O-methyltransferase
258
29467
5.52
8
6
4
2
4
0.29
0.33

DDX3X_MOUSE
ATP-dependent RNA helicase DDX3X
257
73056
6.73
21
11
14
8
14
0.36
0.58

PSB7_MOUSE
Proteasome subunit beta type-7
257
29872
8.14
8
6
5
3
5
0.32
0.52

PNPH_MOUSE
Purine nucleoside phosphorylase
257
32256
5.78
17
10
11
9
11
0.67
2.18

PCNA_MOUSE
Proliferating cell nuclear antigen
256
28766
4.66
15
10
9
5
9
0.66
1.06

SYSC_MOUSE
Serine–tRNA ligase, cytoplasmic
255
58352
5.95
17
12
13
8
13
0.41
0.77

AATM_MOUSE
Aspartate aminotransferase, mitochondrial
255
47381
9.13
32
14
18
10
18
0.54
1.41

RL3_MOUSE
60S ribosomal protein L3
254
46081
10.22
30
20
11
8
11
0.36
1.26

FUMH_MOUSE
Fumarate hydratase, mitochondrial
254
54322
9.12
10
8
8
6
8
0.36
0.59

MAP4_MOUSE
Microtubule-associated protein 4
254
117357
4.9
24
13
14
8
14
0.23
0.33

MAP1B_MOUSE
Microtubule-associated protein 1B
254
270089
4.76
14
8
9
3
9
0.06
0.05

SEC13_MOUSE
Protein SEC13 homolog
253
35543
5.15
10
6
4
3
4
0.19
0.42

LAMP1_MOUSE
Lysosome-associated membrane glycoprotein 1
253
43837
8.66
23
14
8
4
8
0.35
0.61

FBLN2_MOUSE
Fibulin-2
253
131746
4.58
27
12
17
9
17
0.23
0.33

GORS2_MOUSE
Golgi reassembly-stacking protein 2
252
47009
4.68
10
8
4
4
4
0.15
0.56

PSB6_MOUSE
Proteasome subunit beta type-6
250
25362
4.97
14
10
9
7
9
0.67
2.14

SERC_MOUSE
Phosphoserine aminotransferase
249
40447
8.15
26
13
13
8
13
0.55
1.28

ERP29_MOUSE
Endoplasmic reticulum resident protein 29
248
28805
5.9
22
13
9
6
9
0.5
1.37

EHD1_MOUSE
EH domain-containing protein 1
247
60565
6.35
22
9
15
9
15
0.47
0.86

RCN3_MOUSE
Reticulocalbin-3
246
37978
4.74
7
6
4
4
4
0.27
0.55

COPE_MOUSE
Coatomer subunit epsilon
245
34545
4.94
10
7
7
6
7
0.38
1.06

PSME1_MOUSE
Proteasome activator complex subunit 1
244
28655
5.73
13
12
5
4
5
0.34
0.78

TADBP_MOUSE
TAR DNA-binding protein 43
244
44519
6.26
9
9
7
7
7
0.34
0.92

C1QBP_MOUSE
Complement component 1 Q subcomponent-binding Protein, mitochondrial
206
30994
4.82
11
7
7
4
1
0.45
0.71

PUR9_MOUSE
Bifunctional purine biosynthesis protein PURH
242
64177
6.3
27
14
18
12
13
0.52
1.18

RCN2_MOUSE
Reticulocalbin-2
242
37248
4.28
10
8
7
5
7
0.39
0.75

PPIB_MOUSE
Peptidyl-prolyl cis-trans isomerase B
241
23699
9.56
20
9
12
4
12
0.54
1.39

PPIC_MOUSE
Peptidyl-prolyl cis-trans isomerase C
140
22780
6.96
5
5
4
4
4
0.26
1.07

RLA1_MOUSE
60S acidic ribosomal protein P1
240
11468
4.28
6
6
3
3
3
0.53
1.9

SNAA_MOUSE
Alpha-soluble NSF attachment protein
239
33168
5.3
15
11
11
8
11
0.56
1.72

KAD2_MOUSE
Adenylate kinase 2, mitochondrial
239
26452
6.96
8
6
5
4
5
0.3
0.87

GDIR1_MOUSE
Rho GDP-dissociation inhibitor 1
238
23393
5.12
16
12
10
8
10
0.51
3.1

CNN2_MOUSE
Calponin-2
237
33134
7.53
20
7
11
5
4
0.65
0.87

SNX9_MOUSE
Sorting nexin-9
236
66504
5.35
17
10
11
6
11
0.36
0.46

CO3A1_MOUSE
Collagen alpha-1(III) chain
236
138858
6.11
28
13
12
6
8
0.15
0.23

IMA5_MOUSE
Importin subunit alpha-5
195
60144
4.93
8
7
4
3
3
0.18
0.32

AMPL_MOUSE
Cytosol aminopeptidase
234
56106
7.62
22
11
13
10
13
0.4
1.1

PABP1_MOUSE
Polyadenylate-binding protein 1
233
70626
9.52
19
10
16
8
16
0.32
0.7

SPA3N_MOUSE
Serine protease inhibitor A3N
233
46688
5.59
4
4
3
3
3
0.13
0.31

GARS_MOUSE
Glycine–tRNA ligase
233
81826
6.24
15
8
12
6
12
0.33
0.36

AP1B1_MOUSE
AP-1 complex subunit beta-1
231
103869
5.04
17
11
13
8
9
0.26
0.44

NP1L1_MOUSE
Nucleosome assembly protein 1-like 1
231
45317
4.36
19
10
12
6
3
0.5
0.9

MTPN_MOUSE
Myotrophin
227
12853
5.27
12
7
6
4
6
0.68
2.55

GRN_MOUSE
Granulins
227
63413
6.42
21
15
5
4
5
0.14
0.3

CTNA1_MOUSE
Catenin alpha-1
226
100044
5.91
14
10
9
7
9
0.19
0.34

ECHM_MOUSE
Enoyl-CoA hydratase, mitochondrial
226
31454
8.76
10
9
6
5
6
0.29
1.21

ITB2_MOUSE
Integrin beta-2
226
84970
7.02
15
8
8
5
8
0.17
0.28

LKHA4_MOUSE
Leukotriene A-4 hydrolase
226
69007
5.98
13
10
7
6
7
0.21
0.44

MYADM_MOUSE
Myeloid-associated differentiation marker
225
35261
8.69
18
10
4
3
4
0.19
0.42

ARC1B_MOUSE
Actin-related protein 2/3 complex subunit 1B
224
41037
8.69
12
9
8
6
8
0.38
0.84

COPD_MOUSE
Coatomer subunit delta
222
57193
5.89
28
14
12
6
12
0.33
0.55

DUS3_MOUSE
Dual specificity protein phosphatase 3
222
20459
6.07
6
4
5
4
5
0.46
1.24

SYEP_MOUSE
Bifunctional glutamate/proline–tRNA ligase
222
169972
7.75
29
11
21
8
21
0.24
0.22

SC23A_MOUSE
Protein transport protein Sec23A
221
86106
6.64
28
14
18
8
17
0.46
0.55

NDUS1_MOUSE
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
220
79726
5.51
12
6
9
5
9
0.22
0.37

DDX1_MOUSE
ATP-dependent RNA helicase DDX1
220
82448
6.8
16
10
9
4
9
0.16
0.22

SYVC_MOUSE
Valine–tRNA ligase
220
140127
7.9
26
20
15
13
15
0.24
0.52

RS3A_MOUSE
40S ribosomal protein S3a
219
29866
9.75
31
11
17
9
17
0.55
2.49

PLOD3_MOUSE
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
216
84869
5.81
23
14
14
8
14
0.32
0.48

F10A1_MOUSE
Hsc70-interacting protein
216
41630
5.19
10
7
4
3
4
0.15
0.35

LYZ2_MOUSE
Lysozyme C-2
214
16678
9.11
15
6
8
4
8
0.63
3.39

MIF_MOUSE
Macrophage migration inhibitory factor
214
12496
6.79
12
8
6
4
6
0.6
4.07

DEST_MOUSE
Destrin
214
18509
8.14
13
10
10
7
10
0.62
4.9

HCD2_MOUSE
3-Hydroxyacyl-CoA dehydrogenase type-2
214
27402
8.53
11
7
6
4
6
0.39
0.83

DNJA2_MOUSE
DnaJ homolog subfamily A member 2
213
45717
6.06
7
7
3
3
3
0.18
0.31

MARCS_MOUSE
Myristoylated alanine-rich C-kinase substrate
213
29644
4.34
13
9
3
3
3
0.27
0.52

LICH_MOUSE
Lysosomal acid lipase/cholesteryl ester hydrolase
212
45296
8.16
11
10
6
6
6
0.29
0.9

SAE2_MOUSE
SUMO-activating enzyme subunit 2
211
70525
5.09
9
8
5
4
5
0.2
0.27

RL6_MOUSE
60S ribosomal protein L6
210
33489
10.69
17
8
10
5
10
0.37
0.86

FKB10_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP10
208
64656
5.38
21
8
12
6
12
0.3
0.47

IPO4_MOUSE
Importin-4
208
119198
4.92
15
7
12
6
12
0.19
0.23

RL14_MOUSE
60S ribosomal protein L14
206
23549
11.03
12
6
6
2
6
0.33
0.42

PLD3_MOUSE
Phospholipase D3
205
54354
6.07
15
10
9
7
9
0.37
0.85

LRC59_MOUSE
Leucine-rich repeat-containing protein 59
205
34856
9.57
15
5
9
3
9
0.35
0.43

NIBAN_MOUSE
Protein Niban
204
102585
4.72
15
10
9
6
9
0.17
0.28

CATK_MOUSE
Cathepsin K
203
36865
8.61
5
4
4
3
4
0.25
0.4

HMCS1_MOUSE
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
201
57532
5.65
17
10
12
6
12
0.39
0.66

GANAB_MOUSE
Neutral alpha-glucosidase AB
201
106844
5.67
16
11
12
9
12
0.24
0.42

PSB5_MOUSE
Proteasome subunit beta type-5
200
28514
6.52
10
7
7
4
7
0.36
0.79

LEG3_MOUSE
Galectin-3
200
27498
8.46
27
10
14
6
14
0.42
1.47

SYNC_MOUSE
Asparagine–tRNA ligase, cytoplasmic
197
64238
5.62
19
11
15
9
15
0.41
0.79

DCTN2_MOUSE
Dynactin subunit 2
197
44090
5.14
8
5
8
5
8
0.34
0.6

ZYX_MOUSE
Zyxin
197
60507
5.99
15
7
7
3
7
0.22
0.23

LTOR3_MOUSE
Ragulator complex protein LAMTOR3
195
13544
6.73
7
7
4
4
4
0.63
2.34

S10AB_MOUSE
Protein S100-A11
195
11075
5.28
8
6
4
3
4
0.77
3.32

VATL_MOUSE
V-type proton ATPase 16 kDa proteolipid subunit
195
15798
9.1
4
3
2
1
2
0.32
0.68

VMA5A_MOUSE
von Willebrand factor A domain-containing protein 5A
194
87087
6.15
10
5
9
4
9
0.23
0.21

IBP7_MOUSE
Insulin-like growth factor-binding protein 7
194
28951
8.71
16
7
8
3
8
0.46
0.54

EIF3H_MOUSE
Eukaryotic translation initiation factor 3 subunit H
192
39807
6.2
8
7
6
5
6
0.34
0.68

FHL2_MOUSE
Four and a half LIM domains protein 2
192
32051
7.31
14
6
6
3
6
0.28
0.47

PRS6B_MOUSE
26S proteasome regulatory subunit 6B
192
47379
5.09
9
5
8
4
8
0.4
0.42

ETFA_MOUSE
Electron transfer flavoprotein subunit alpha, mitochondrial
190
34988
8.62
17
8
8
5
7
0.47
0.81

CSF1_MOUSE
Macrophage colony-stimulating factor 1
190
60611
5.1
9
7
4
3
4
0.13
0.32

P4HA2_MOUSE
Prolyl 4-hydroxylase subunit alpha-2
189
60964
5.55
24
10
12
9
12
0.35
0.85

LAMB1_MOUSE
Laminin subunit beta-1
188
196961
4.82
17
5
12
3
12
0.12
0.07

TCPG_MOUSE
T-complex protein 1 subunit gamma
188
60591
6.28
25
8
17
6
17
0.42
0.51

SQSTM_MOUSE
Sequestosome-1
186
48132
5.09
10
7
6
4
6
0.28
0.41

DC1I2_MOUSE
Cytoplasmic dynein 1 intermediate chain 2
185
68352
5.16
5
4
4
3
4
0.19
0.2

CATA_MOUSE
Catalase
184
59758
7.72
15
6
11
4
11
0.35
0.32

VATC1_MOUSE
V-type proton ATPase subunit C 1
183
43860
7.02
8
5
5
3
5
0.25
0.33

ECHB_MOUSE
Trifunctional enzyme subunit beta, mitochondrial
183
51353
9.43
10
6
8
5
8
0.32
0.5

STIP1_MOUSE
Stress-induced phosphoprotein 1
183
62542
6.4
15
6
11
4
11
0.35
0.31

THY1_MOUSE
Thy-1 membrane glycoprotein
182
18069
9.16
14
8
5
2
5
0.49
0.58

PYRG1_MOUSE
CTP synthase 1
182
66640
6.14
17
10
11
7
11
0.33
0.65

GSTO1_MOUSE
Glutathione S-transferase omega-1
181
27480
6.92
36
11
19
7
19
0.83
1.87

HNRPM_MOUSE
Heterogeneous nuclear ribonucleoprotein M
180
77597
8.8
16
8
11
6
11
0.23
0.38

PCOC1_MOUSE
Procollagen C-endopeptidase enhancer 1
180
50136
8.73
14
6
9
4
9
0.38
0.39

ATPO_MOUSE
ATP synthase subunit O, mitochondrial
180
23349
10
10
7
6
5
6
0.38
1.43

IDH3A_MOUSE
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
179
39613
6.27
9
5
4
1
4
0.15
0.23

POSTN_MOUSE
Periostin
179
93085
7.27
15
7
10
4
10
0.25
0.2

HCDH_MOUSE
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
179
34442
8.76
10
6
6
4
6
0.5
0.62

DHB4_MOUSE
Peroxisomal multifunctional enzyme type 2
179
79432
8.76
22
13
13
8
13
0.24
0.52

PTGIS_MOUSE
Prostacyclin synthase
178
57011
6.26
21
9
18
8
18
0.53
0.79

TPP1_MOUSE
Tripeptidyl-peptidase 1
177
61304
6.1
8
7
6
5
6
0.21
0.5

SAE1_MOUSE
SUMO-activating enzyme subunit 1
177
38596
5.24
7
5
5
3
5
0.24
0.38

6PGL_MOUSE
6-Phosphogluconolactonase
177
27237
5.55
9
6
5
2
5
0.35
0.36

SUCB1_MOUSE
Succinate–CoA ligase [ADP-forming] subunit beta, mitochondrial
176
50082
6.57
8
5
6
3
6
0.27
0.28

IDI1_MOUSE
Isopentenyl-diphosphate delta-isomerase 1
175
26272
5.79
14
5
6
4
6
0.49
0.88

PLIN3_MOUSE
Perilipin-3
175
47233
5.45
12
9
10
8
10
0.43
1.02

RL7_MOUSE
60S ribosomal protein L7
174
31400
10.89
19
9
13
5
13
0.46
0.93

RAB1B_MOUSE
Ras-related protein Rab-1B
130
22173
5.55
15
7
10
5
4
0.52
1.53

FERM2_MOUSE
Fermitin family homolog 2
174
77750
6.26
9
4
6
3
6
0.18
0.18

CAZA2_MOUSE
F-actin-capping protein subunit alpha-2
173
32947
5.57
19
10
11
7
4
0.65
1.41

CAZA1_MOUSE
F-actin-capping protein subunit alpha-1
61
32919
5.34
9
3
7
3
5
0.44
0.46

EIF3K_MOUSE
Eukaryotic translation initiation factor 3 subunit K
173
25070
4.81
10
3
8
2
8
0.61
0.39

G6PD1_MOUSE
Glucose-6-phosphate 1-dehydrogenase X
172
59225
6.06
22
11
14
7
14
0.4
0.64

ASAH1_MOUSE
Acid ceramidase
172
44641
8.68
10
7
9
6
9
0.3
0.75

ADHX_MOUSE
Alcohol dehydrogenase class-3
172
39522
6.97
14
7
9
7
9
0.51
1.09

IF4G1_MOUSE
Eukaryotic translation initiation factor 4 gamma 1
172
175967
5.3
16
10
11
7
11
0.11
0.18

IL6RB_MOUSE
Interleukin-6 receptor subunit beta
171
102387
5.35
14
8
4
2
4
0.06
0.09

NMT1_MOUSE
Glycylpeptide N-tetradecanoyltransferase 1
171
56852
8.04
8
5
6
3
6
0.24
0.25

ANXA4_MOUSE
Annexin A4
170
35893
5.43
10
7
8
5
8
0.3
0.78

PCYOX_MOUSE
Prenylcysteine oxidase
169
56459
6.44
8
5
7
4
7
0.24
0.34

BASP1_MOUSE
Brain acid soluble protein 1
168
22074
4.5
21
9
5
3
5
0.42
0.75

PSMD5_MOUSE
26S proteasome non-ATPase regulatory subunit 5
168
55937
5.13
10
5
7
3
7
0.28
0.25

IPYR_MOUSE
Inorganic pyrophosphatase
165
32646
5.37
6
4
4
2
4
0.26
0.29

ISG15_MOUSE
Ubiquitin-like protein ISG15
164
17886
7.74
6
5
3
2
3
0.5
0.58

ACO13_MOUSE
Acyl-coenzyme A thioesterase 13
164
15173
8.95
8
7
5
5
5
0.56
2.84

CP51A_MOUSE
Lanosterol 14-alpha demethylase
164
56739
8.6
12
4
8
3
5
0.3
0.25

IMPA1_MOUSE
Inositol monophosphatase 1
163
30416
5.08
13
4
5
2
5
0.21
0.31

P3H1_MOUSE
Prolyl 3-hydroxylase 1
162
83598
5.03
12
6
8
4
8
0.22
0.22

SDHA_MOUSE
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
161
72539
7.06
12
9
5
4
5
0.15
0.26

VPS25_MOUSE
Vacuolar protein-sorting-associated protein 25
161
20735
5.97
4
4
1
1
1
0.19
0.49

PHB_MOUSE
Prohibitin
159
29802
5.57
17
10
11
7
11
0.65
1.65

PSA6_MOUSE
Proteasome subunit alpha type-6
158
27355
6.34
14
5
8
3
8
0.52
0.58

TOM40_MOUSE
Mitochondrial import receptor subunit TOM40 homolog
156
37871
7.64
10
8
6
4
6
0.32
0.73

UBP5_MOUSE
Ubiquitin carboxyl-terminal hydrolase 5
156
95772
4.89
18
10
10
7
10
0.23
0.36

EFTU_MOUSE
Elongation factor Tu, mitochondrial
156
49477
7.23
16
5
12
3
11
0.44
0.29

DHB7_MOUSE
3-Keto-steroid reductase
154
37293
6.25
9
5
6
4
6
0.26
0.75

CAVN1_MOUSE
Caveolae-associated protein 1
153
43927
5.43
7
6
3
2
3
0.15
0.21

ODPB_MOUSE
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
152
38912
6.41
14
7
6
4
6
0.32
0.53

DNPEP_MOUSE
Aspartyl aminopeptidase
152
52174
6.82
18
12
10
7
10
0.41
0.75

PRDX5_MOUSE
Peroxiredoxin-5, mitochondrial
151
21884
9.1
20
5
10
4
10
0.54
1.13

ARPC2_MOUSE
Actin-related protein 2/3 complex subunit 2
150
34336
6.84
13
4
10
2
10
0.39
0.27

PCKGM_MOUSE
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
150
70482
6.92
4
3
3
2
3
0.08
0.13

GLCM_MOUSE
Glucosylceramidase
150
57585
7.64
14
10
10
8
10
0.37
0.78

NB5R1_MOUSE
NADH-cytochrome b5 reductase 1
150
34113
8.97
4
3
4
3
4
0.26
0.44

PUR6_MOUSE
Multifunctional protein ADE2
149
46976
6.94
11
6
8
5
8
0.37
0.56

LPPRC_MOUSE
Leucine-rich PPR motif-containing protein, mitochondrial
149
156516
6.42
18
4
14
4
14
0.16
0.11

SAC1_MOUSE
Phosphatidylinositide phosphatase SAC1
148
66901
6.85
9
4
4
2
4
0.12
0.13

GFPT2_MOUSE
Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 2
147
76960
6.72
10
4
9
4
9
0.21
0.24

MTAP_MOUSE
S-Methyl-5-thioadenosine phosphorylase
146
31042
6.71
7
4
5
3
5
0.29
0.49

IKIP_MOUSE
Inhibitor of nuclear factor kappa-B kinase-interacting protein
146
42505
5.03
13
10
4
2
4
0.29
0.22

ADPGK_MOUSE
ADP-dependent glucokinase
146
53869
5.37
9
7
4
3
4
0.15
0.26

MA2A1_MOUSE
Alpha-mannosidase 2
145
131548
8.17
12
7
10
6
10
0.15
0.21

SYLC_MOUSE
Leucine–tRNA ligase, cytoplasmic
145
134106
6.64
13
6
10
4
10
0.16
0.13

SYIC_MOUSE
Isoleucine–tRNA ligase, cytoplasmic
145
144179
6.14
18
8
12
5
12
0.19
0.16

PARVA_MOUSE
Alpha-parvin
144
42304
5.69
9
5
5
3
5
0.26
0.34

DYN2_MOUSE
Dynamin-2
144
98084
7.02
12
5
9
3
7
0.19
0.14

IMA1_MOUSE
Importin subunit alpha-1
144
57892
5.49
13
4
8
3
8
0.27
0.24

CYGB_MOUSE
Cytoglobin
144
21452
6.32
8
4
3
2
3
0.33
0.47

ODO1_MOUSE
2-Oxoglutarate dehydrogenase, mitochondrial
143
116375
6.36
34
6
9
4
9
0.14
0.15

MK01_MOUSE
Mitogen-activated protein kinase 1
143
41249
6.5
8
5
7
4
7
0.38
0.5

UD17C_MOUSE
UDP-glucuronosyltransferase 1-7C
143
59719
8.64
14
5
8
3
8
0.27
0.23

HMOX1_MOUSE
Heme oxygenase 1
142
32908
6.08
16
7
10
6
10
0.57
1.13

USO1_MOUSE
General vesicular transport factor p115
142
106917
4.85
11
7
10
6
10
0.17
0.26

RTN4_MOUSE
Reticulon-4
142
126535
4.47
23
9
10
5
10
0.16
0.18

THIKA_MOUSE
3-Ketoacyl-CoA thiolase A, peroxisomal
141
43926
8.74
14
8
10
5
10
0.47
0.61

MGST1_MOUSE
Microsomal glutathione S-transferase 1
141
17540
9.67
6
5
2
2
2
0.22
0.6

HYEP_MOUSE
Epoxide hydrolase 1
141
52543
8.43
18
5
14
4
14
0.41
0.37

GUAD_MOUSE
Guanine deaminase
141
50981
5.36
6
5
4
3
4
0.24
0.28

LASP1_MOUSE
LIM and SH3 domain protein 1
140
29975
6.61
23
7
7
2
7
0.29
0.51

4F2_MOUSE
4F2 cell-surface antigen heavy chain
139
58300
5.62
12
8
7
5
7
0.26
0.43

PPAC_MOUSE
Low molecular weight phosphotyrosine protein phosphatase
139
18180
6.3
6
3
4
3
4
0.45
0.97

CD36_MOUSE
Platelet glycoprotein 4
139
52664
8.6
6
5
6
5
6
0.19
0.49

ATPG_MOUSE
ATP synthase subunit gamma, mitochondrial
139
32865
9.06
9
6
6
3
6
0.3
0.46

AL9A1_MOUSE
4-Trimethylaminobutyraldehyde dehydrogenase
138
53480
6.63
7
6
4
3
4
0.18
0.26

ASPH_MOUSE
Aspartyl/asparaginyl beta-hydroxylase
138
82991
4.97
6
4
5
3
5
0.1
0.16

ATPD_MOUSE
ATP synthase subunit delta, mitochondrial
138
17589
5.03
14
9
5
2
5
0.63
0.6

IRGM1_MOUSE
Immunity-related GTPase family M protein 1
137
46522
8.56
7
5
4
4
4
0.2
0.43

PON3_MOUSE
Serum paraoxonase/lactonase 3
137
39326
5.44
9
5
5
4
5
0.26
0.53

UMPS_MOUSE
Uridine 5-monophosphate synthase
137
52259
6.17
7
5
6
4
6
0.23
0.38

CMTD1_MOUSE
Catechol O-methyltransferase domain-containing protein 1
137
28943
8.61
7
4
6
3
6
0.51
0.54

SYUG_MOUSE
Gamma-synuclein
137
13152
4.68
6
5
3
3
3
0.4
1.54

CLIC4_MOUSE
Chloride intracellular channel protein 4
137
28711
5.44
10
7
8
5
7
0.41
1.06

CRIP2_MOUSE
Cysteine-rich protein 2
136
22712
8.94
8
5
3
3
3
0.34
1.07

PLOD1_MOUSE
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
136
83542
6.08
12
5
10
4
10
0.2
0.22

CPNE1_MOUSE
Copine-1
136
58849
5.4
7
4
5
3
5
0.18
0.24

RL4_MOUSE
60S ribosomal protein L4
136
47124
11.01
40
10
20
9
20
0.45
1.21

RN213_MOUSE
E3 ubiquitin-protein ligase RNF213
135
584411
6.35
29
8
22
6
22
0.09
0.04

CD109_MOUSE
CD109 antigen
134
161557
5.37
5
5
4
4
4
0.05
0.11

LAMP2_MOUSE
Lysosome-associated membrane glycoprotein 2
134
45652
7.05
11
4
7
3
7
0.16
0.31

ARL8A_MOUSE
ADP-ribosylation factor-like protein 8A
134
21376
7.63
14
8
6
4
6
0.4
1.16

NCEH1_MOUSE
Neutral cholesterol ester hydrolase 1
133
45711
6.56
12
7
7
4
7
0.34
0.44

GNPI1_MOUSE
Glucosamine-6-phosphate isomerase 1
133
32528
6.13
8
5
7
4
7
0.36
0.67

NOMO1_MOUSE
Nodal modulator 1
133
133336
5.75
13
8
10
7
10
0.19
0.25

RRAS_MOUSE
Ras-related protein R-Ras
133
23749
6.32
6
4
4
3
2
0.23
0.68

RCN1_MOUSE
Reticulocalbin-1
133
38090
4.7
12
6
6
4
6
0.25
0.55

PFKAP_MOUSE
ATP-dependent 6-phosphofructokinase, platelet type
132
85400
6.73
12
4
9
2
9
0.24
0.1

BLVRB_MOUSE
Flavin reductase (NADPH)
132
22183
6.49
15
6
9
5
9
0.69
1.53

TMM43_MOUSE
Transmembrane protein 43
132
44755
6.85
6
5
6
5
6
0.31
0.59

P5CS_MOUSE
Delta-1-pyrroline-5-carboxylate synthase
131
87212
7.18
12
5
9
4
9
0.19
0.21

MATR3_MOUSE
Matrin-3
131
94572
5.87
6
4
5
3
5
0.14
0.14

PTGR1_MOUSE
Prostaglandin reductase 1
131
35537
8.09
5
5
5
5
5
0.26
0.79

COTL1_MOUSE
Coactosin-like protein
131
15934
5.28
10
3
6
2
6
0.55
0.67

ACAD9_MOUSE
Acyl-CoA dehydrogenase family member 9, mitochondrial
131
68679
7.16
6
6
3
3
3
0.11
0.2

IFM3_MOUSE
Interferon-induced transmembrane protein 3
130
14945
6.89
14
6
3
3
2
0.32
1.98

IFM2_MOUSE
Interferon-induced transmembrane protein 2
59
15733
6.81
9
3
3
2
2
0.17
0.68

DHX9_MOUSE
ATP-dependent RNA helicase A
130
149381
6.39
17
9
11
5
11
0.13
0.15

SDCB1_MOUSE
Syntenin-1
130
32359
6.66
9
4
4
3
4
0.29
0.47

ORN_MOUSE
Oligoribonuclease, mitochondrial
129
26722
6.67
8
4
6
3
6
0.38
0.59

ITM2B_MOUSE
Integral membrane protein 2B
128
30240
5.14
16
7
7
5
7
0.45
0.99

EIF3I_MOUSE
Eukaryotic translation initiation factor 3 subunit I
128
36438
5.38
15
6
9
5
9
0.47
0.77

FIS1_MOUSE
Mitochondrial fission 1 protein
128
16998
8.56
5
4
4
3
4
0.31
1.07

SAHH_MOUSE
Adenosylhomocysteinase
128
47657
6.08
15
8
11
7
11
0.43
0.84

TFR1_MOUSE
Transferrin receptor protein 1
127
85677
6.13
4
4
3
3
3
0.05
0.16

STML2_MOUSE
Stomatin-like protein 2, mitochondrial
127
38361
8.95
13
8
9
6
9
0.52
0.91

IF6_MOUSE
Eukaryotic translation initiation factor 6
127
26494
4.63
7
6
5
4
5
0.56
1.18

VPP1_MOUSE
V-type proton ATPase 116 kDa subunit a isoform 1
126
96404
6.29
10
4
7
3
7
0.13
0.14

PREP_MOUSE
Presequence protease, mitochondrial
126
117297
6.76
10
6
10
6
10
0.17
0.24

BIN1_MOUSE
Myc box-dependent-interacting protein 1
125
64430
4.95
16
6
10
5
10
0.32
0.38

CSN7A_MOUSE
COP9 signalosome complex subunit 7a
125
30206
7.68
8
6
4
3
4
0.26
0.51

SSRD_MOUSE
Translocon-associated protein subunit delta
125
18924
5.5
7
6
3
2
3
0.25
0.55

COR1B_MOUSE
Coronin-1B
124
53878
5.54
15
7
7
3
7
0.29
0.26

VKOR1_MOUSE
Vitamin K epoxide reductase complex subunit 1
124
17756
9.37
6
4
2
2
2
0.19
0.59

FUBP2_MOUSE
Far upstream element-binding protein 2
124
76728
6.9
11
4
7
3
7
0.12
0.18

MFGM_MOUSE
Lactadherin
122
51208
6.1
22
9
13
7
13
0.45
0.77

PSME2_MOUSE
Proteasome activator complex subunit 2
122
27040
5.54
10
6
7
4
7
0.46
0.84

C1TC_MOUSE
C-1-tetrahydrofolate synthase, cytoplasmic
122
101136
6.7
12
5
8
3
8
0.12
0.13

RISC_MOUSE
Retinoid-inducible serine carboxypeptidase
122
50932
5.48
11
5
8
4
8
0.21
0.39

ETFB_MOUSE
Electron transfer flavoprotein subunit beta
122
27606
8.24
16
4
8
2
8
0.43
0.35

PRRC1_MOUSE
Protein PRRC1
122
46268
5.62
10
5
8
5
8
0.31
0.57

MAOM_MOUSE
NAD-dependent malic enzyme, mitochondrial
121
65757
7.53
6
5
3
3
3
0.15
0.21

SH3L1_MOUSE
SH3 domain-binding glutamic acid-rich-like protein
120
12803
4.87
4
3
3
2
3
0.38
0.89

PSB1_MOUSE
Proteasome subunit beta type-1
120
26355
7.67
9
5
7
4
7
0.55
0.88

LY6E_MOUSE
Lymphocyte antigen 6E
120
13791
6.67
4
3
2
2
2
0.29
1.44

SPRC_MOUSE
SPARC
120
34428
4.77
8
5
6
4
6
0.33
0.62

ECI2_MOUSE
Enoyl-CoA delta isomerase 2, mitochondrial
119
43240
9.08
9
5
4
1
4
0.16
0.1

AIMP2_MOUSE
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
119
35355
7.7
9
6
5
4
5
0.34
0.6

TOM1_MOUSE
Target of Myb protein 1
119
54291
4.83
5
4
5
4
5
0.22
0.36

TALDO_MOUSE
Transaldolase
119
37363
6.57
16
5
10
4
10
0.31
0.56

SAMH1_MOUSE
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
118
72604
8.17
8
4
6
2
6
0.17
0.12

LPP_MOUSE
Lipoma-preferred partner homolog
118
65848
7.19
11
7
6
4
6
0.22
0.29

STX12_MOUSE
Syntaxin-12
118
31176
5.33
9
5
8
4
8
0.45
0.7

CYB5B_MOUSE
Cytochrome b5 type B
118
16308
4.79
5
4
4
3
4
0.51
1.13

PDLI1_MOUSE
PDZ and LIM domain protein 1
117
35752
6.38
9
4
7
4
7
0.38
0.59

FABP4_MOUSE
Fatty acid-binding protein, adipocyte
117
14641
8.53
6
3
5
3
5
0.47
1.31

BACH_MOUSE
Cytosolic acyl coenzyme A thioester hydrolase
117
42510
8.9
6
3
5
3
5
0.24
0.34

NSF1C_MOUSE
NSFL1 cofactor p47
117
40685
5.04
9
7
2
2
2
0.11
0.23

CMC1_MOUSE
Calcium-binding mitochondrial carrier protein Aralar1
117
74523
8.43
8
2
7
2
7
0.18
0.12

S10A1_MOUSE
Protein S100-A1
117
10498
4.37
2
2
1
1
1
0.16
0.47

ACDSB_MOUSE
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
116
47843
8
7
4
4
2
4
0.19
0.19

CO4A1_MOUSE
Collagen alpha-1(IV) chain
116
160579
8.51
16
3
8
2
8
0.13
0.08

SPEE_MOUSE
Spermidine synthase
116
33973
5.31
10
4
10
4
10
0.65
0.63

EDC4_MOUSE
Enhancer of mRNA-decapping protein 4
115
152389
5.51
6
4
3
2
3
0.03
0.06

SGT1_MOUSE
Protein SGT1 homolog
115
38135
5.32
4
3
3
2
3
0.16
0.24

SQOR_MOUSE
Sulfide:quinone oxidoreductase, mitochondrial
115
50250
9.2
6
4
4
2
4
0.12
0.18

SYWC_MOUSE
Tryptophan–tRNA ligase, cytoplasmic
114
54323
6.44
9
5
7
4
7
0.26
0.36

PDXD1_MOUSE
Pyridoxal-dependent decarboxylase domain-containing protein 1
114
87281
5.31
12
6
7
4
7
0.18
0.21

BROX_MOUSE
BRO1 domain-containing protein BROX
114
46172
7.59
6
4
2
2
2
0.11
0.2

SCFD1_MOUSE
Sec1 family domain-containing protein 1
112
72277
5.98
5
2
5
2
5
0.19
0.12

DHPR_MOUSE
Dihydropteridine reductase
113
25554
7.67
4
2
2
1
2
0.11
0.18

NDUS3_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
113
30131
6.67
4
3
2
1
2
0.11
0.15

TAGL_MOUSE
Transgelin
113
22561
8.85
12
6
8
5
8
0.51
2

PALLD_MOUSE
Palladin
113
152037
5.87
11
4
9
3
9
0.11
0.09

RL18_MOUSE
60S ribosomal protein L18
112
21631
11.79
7
6
4
3
4
0.25
0.77

MPCP_MOUSE
Phosphate carrier protein, mitochondrial
112
39606
9.36
39
5
9
3
9
0.28
0.37

CYFP1_MOUSE
Cytoplasmic FMR1-interacting protein 1
112
145148
6.46
6
3
6
3
6
0.07
0.09

G3BP1_MOUSE
Ras GTPase-activating protein-binding protein 1
112
51797
5.41
6
4
6
4
6
0.17
0.38

PYGB_MOUSE
Glycogen phosphorylase, brain form
112
96668
6.28
8
3
7
2
7
0.15
0.09

S10A6_MOUSE
Protein S100-A6
112
10044
5.3
12
5
6
3
6
0.66
4.05

TCTP_MOUSE
Translationally-controlled tumor protein
110
19450
4.76
9
4
5
3
5
0.31
0.89

RL5_MOUSE
60S ribosomal protein L5
110
34379
9.78
12
4
9
3
9
0.43
0.44

SYHC_MOUSE
Histidine–tRNA ligase, cytoplasmic
110
57396
5.79
10
5
6
4
6
0.22
0.34

CLPT1_MOUSE
Cleft lip and palate transmembrane protein 1 homolog
109
75243
5.88
13
9
5
4
5
0.18
0.25

ACSF2_MOUSE
Acyl-CoA synthetase family member 2, mitochondrial
109
67907
8.44
7
4
6
3
6
0.2
0.2

THIL_MOUSE
Acetyl-CoA acetyltransferase, mitochondrial
108
44787
8.71
15
9
6
4
6
0.23
0.45

USMG5_MOUSE
Upregulated during skeletal muscle growth protein 5
108
6377
9.84
2
2
1
1
1
0.26
0.87

ISC2A_MOUSE
Isochorismatase domain-containing protein 2A
108
22403
8.25
2
2
1
1
1
0.09
0.2

HNRPL_MOUSE
Heterogeneous nuclear ribonucleoprotein L
107
63923
8.33
14
6
6
2
6
0.24
0.14

PP1R7_MOUSE
Protein phosphatase 1 regulatory subunit 7
106
41266
4.85
3
3
2
2
2
0.11
0.22

SE1L1_MOUSE
Protein sel-1 homolog 1
106
88285
5.36
4
3
3
2
3
0.1
0.1

CCD47_MOUSE
Coiled-coil domain-containing protein 47
106
55808
4.74
6
5
3
2
1
0.14
0.16

HUWE1_MOUSE
E3 ubiquitin-protein ligase HUWE1
105
482332
5.1
15
2
13
1
13
0.06
0.01

GDIR2_MOUSE
Rho GDP-dissociation inhibitor 2
104
22836
4.97
5
4
4
3
4
0.45
0.72

SGPL1_MOUSE
Sphingosine-1-phosphate lyase 1
104
63636
9.2
12
5
8
4
8
0.29
0.3

PLIN4_MOUSE
Perilipin-4
104
139328
8.81
7
4
6
3
6
0.07
0.09

UBA6_MOUSE
Ubiquitin-like modifier-activating enzyme 6
104
117891
5.75
6
2
5
1
5
0.07
0.04

ARL1_MOUSE
ADP-ribosylation factor-like protein 1
104
20398
5.63
8
5
6
3
6
0.57
0.83

G6PE_MOUSE
GDH/6PGL endoplasmic bifunctional protein
103
88872
6.44
6
4
5
3
5
0.11
0.15

UBP14_MOUSE
Ubiquitin carboxyl-terminal hydrolase 14
103
55966
5.15
8
4
7
3
7
0.25
0.25

FSTL1_MOUSE
Follistatin-related protein 1
103
34532
5.58
6
2
5
1
5
0.21
0.13

PGFRB_MOUSE
Platelet-derived growth factor receptor beta
103
122728
4.99
10
7
7
4
7
0.12
0.15

CD180_MOUSE
CD180 antigen
103
74255
5.55
4
2
3
1
3
0.12
0.06

GLRX1_MOUSE
Glutaredoxin-1
103
11863
8.67
4
3
2
1
2
0.49
0.41

GCN1_MOUSE
eIF-2-alpha kinase activator GCN1
102
292834
7.14
18
5
16
3
16
0.12
0.04

PLPP3_MOUSE
Phospholipid phosphatase 3
102
35193
9.25
6
4
4
2
4
0.23
0.27

NU155_MOUSE
Nuclear pore complex protein Nup155
101
155019
5.77
9
4
7
2
7
0.09
0.06

ACADV_MOUSE
Very-long-chain-specific acyl-CoA dehydrogenase, mitochondrial
95
70831
8.91
3
2
3
2
3
0.08
0.13

PFD5_MOUSE
Prefoldin subunit 5
101
17345
5.93
8
2
5
2
5
0.43
0.61

PSA2_MOUSE
Proteasome subunit alpha type-2
101
25910
6.92
9
5
8
5
8
0.52
1.22

ZWINT_MOUSE
ZW10 interactor
101
28695
8.56
4
2
3
1
3
0.24
0.33

ERG7_MOUSE
Lanosterol synthase
101
83088
5.96
13
4
10
4
10
0.21
0.22

EMC1_MOUSE
ER membrane protein complex subunit 1
100
111535
7
12
6
11
5
11
0.19
0.21

PYC_MOUSE
Pyruvate carboxylase, mitochondrial
100
129602
6.25
4
2
4
2
4
0.07
0.07

SRPRB_MOUSE
Signal recognition particle receptor subunit beta
99
29561
9.34
7
5
4
2
4
0.26
0.32

CD34_MOUSE
Hematopoietic progenitor cell antigen CD34
99
40957
5.2
1
1
1
1
1
0.05
0.11

AIFM1_MOUSE
Apoptosis-inducing factor 1, mitochondrial
98
66724
9.23
5
3
4
3
4
0.14
0.21

3HIDH_MOUSE
3-Hydroxyisobutyrate dehydrogenase, mitochondrial
98
35417
8.37
6
3
5
2
5
0.31
0.26

ATLA3_MOUSE
Atlastin-3
98
60537
5.73
7
5
5
4
5
0.18
0.32

TXTP_MOUSE
Tricarboxylate transport protein, mitochondrial
98
33910
9.91
6
2
4
2
4
0.27
0.28

IF1A_MOUSE
Eukaryotic translation initiation factor 1A
98
16492
5.07
8
4
3
1
3
0.21
0.28

TRI25_MOUSE
E3 ubiquitin/ISG15 ligase TRIM25
98
71680
8.62
9
2
7
2
7
0.21
0.12

QCR1_MOUSE
Cytochrome b-c1 complex subunit 1, mitochondrial
97
52818
5.81
11
3
6
2
6
0.26
0.17

ACACA_MOUSE
Acetyl-CoA carboxylase 1
96
265088
5.97
11
6
10
5
10
0.11
0.08

DYLT1_MOUSE
Dynein light chain Tctex-type 1
95
12475
5
1
1
1
1
1
0.16
0.39

ATOX1_MOUSE
Copper transport protein ATOX1
95
7334
6.04
5
3
3
2
3
0.72
4.12

RENBP_MOUSE
N-Acylglucosamine 2-epimerase
94
49739
5.69
4
3
3
2
3
0.13
0.18

ROAA_MOUSE
Heterogeneous nuclear ribonucleoprotein A/B
94
30812
7.68
15
6
7
5
6
0.29
0.96

GNS_MOUSE
N-Acetylglucosamine-6-sulfatase
94
61136
8.52
13
5
8
3
8
0.22
0.23

TMX1_MOUSE
Thioredoxin-related transmembrane protein 1
93
31376
5.19
3
3
1
1
1
0.04
0.14

OCAD1_MOUSE
OCIA domain-containing protein 1
90
27593
7.66
4
3
3
2
3
0.2
0.35

STS_MOUSE
Steryl-sulfatase
93
66549
8.83
2
2
1
1
1
0.03
0.06

TIF1B_MOUSE
Transcription intermediary factor 1-beta
93
88791
5.52
11
4
7
4
7
0.12
0.21

LMAN2_MOUSE
Vesicular integral-membrane protein VIP36
92
40404
6.46
10
4
8
3
8
0.32
0.36

SH3L3_MOUSE
SH3 domain-binding glutamic acid-rich-like protein 3
92
10470
5.02
10
6
4
2
4
0.68
3.72

PTGR3_MOUSE
Prostaglandin reductase-3
92
40503
7.01
4
3
4
3
4
0.25
0.36

KIME_MOUSE
Mevalonate kinase
91
41851
6.22
5
2
5
2
5
0.3
0.22

PAPS2_MOUSE
Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2
91
70306
7.31
8
3
7
3
7
0.24
0.2

PGRC1_MOUSE
Membrane-associated progesterone receptor component 1
91
21681
4.57
8
5
4
3
4
0.4
0.77

FRIH_MOUSE
Ferritin heavy chain
90
21053
5.53
16
6
9
4
9
0.73
1.19

THIM_MOUSE
3-Ketoacyl-CoA thiolase, mitochondrial
90
41803
8.33
13
8
8
4
8
0.34
0.49

LGMN_MOUSE
Legumain
90
49341
5.92
6
3
5
2
5
0.22
0.18

CD9_MOUSE
CD9 antigen
90
25241
6.88
4
3
1
1
1
0.11
0.39

HEBP1_MOUSE
Heme-binding protein 1
90
21053
5.18
2
1
2
1
2
0.29
0.22

SCPDL_MOUSE
Saccharopine dehydrogenase-like oxidoreductase
90
47099
8.86
4
4
2
2
2
0.13
0.19

TOIP1_MOUSE
Torsin-1A-interacting protein 1
90
66740
6.58
2
1
2
1
2
0.04
0.06

ACADL_MOUSE
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
89
47877
8.53
15
5
8
4
8
0.35
0.42

PTGES_MOUSE
Prostaglandin E synthase
89
17274
9.47
2
2
1
1
1
0.17
0.27

PSA1_MOUSE
Proteasome subunit alpha type-1
89
29528
6
11
5
7
4
7
0.32
0.75

DX39A_MOUSE
ATP-dependent RNA helicase DDX39A
89
49036
5.46
5
2
5
2
5
0.23
0.19

ATP5H_MOUSE
ATP synthase subunit d, mitochondrial
89
18738
5.52
7
4
6
3
6
0.55
0.93

CNPY2_MOUSE
Protein canopy homolog 2
88
20754
4.95
8
5
3
2
3
0.28
0.49

AACS_MOUSE
Acetoacetyl-CoA synthetase
88
75152
6.25
15
5
11
5
11
0.28
0.32

GNAS1_MOUSE
Guanine nucleotide-binding protein G(s) subunit alpha isoforms Xlas
88
121429
4.72
15
5
8
3
7
0.11
0.11

HA11_MOUSE
H-2 class I histocompatibility antigen, D-B alpha chain
88
40810
6.28
13
2
8
2
8
0.29
0.23

GNA11_MOUSE
Guanine nucleotide-binding protein subunit alpha-11
88
41997
5.7
7
4
5
3
2
0.22
0.35

VATG1_MOUSE
V-type proton ATPase subunit G 1
88
13716
7.77
4
3
2
1
2
0.24
0.35

NDUS5_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
87
12639
9.1
1
1
1
1
1
0.11
0.38

SYFB_MOUSE
Phenylalanine–tRNA ligase beta subunit
87
65655
6.69
8
3
8
3
8
0.21
0.21

THOP1_MOUSE
Thimet oligopeptidase
87
77976
5.72
3
3
2
2
2
0.04
0.11

HSPB1_MOUSE
Heat shock protein beta-1
86
23000
6.12
9
2
7
2
7
0.56
0.43

IF2G_MOUSE
Eukaryotic translation initiation factor 2 subunit 3, X-linked
86
51033
8.66
15
5
10
5
10
0.3
0.5

PDIA5_MOUSE
Protein disulfide-isomerase A5
86
59229
7.25
6
2
5
1
5
0.22
0.15

BAG3_MOUSE
BAG family molecular chaperone regulator 3
86
61822
6.78
12
4
7
3
7
0.23
0.22

MRGRF_MOUSE
Mas-related G-protein coupled receptor member F
86
38497
9
2
2
1
1
1
0.06
0.11

SET_MOUSE
Protein SET
85
33358
4.22
10
3
7
3
7
0.37
0.45

GLTP_MOUSE
Glycolipid transfer protein
85
23674
6.9
2
2
2
2
2
0.2
0.42

DPP3_MOUSE
Dipeptidyl peptidase 3
85
82846
5.26
6
3
4
1
4
0.12
0.05

CARM1_MOUSE
Histone-arginine methyltransferase CARM1
85
65811
6.28
5
3
4
3
4
0.12
0.21

SERC1_MOUSE
Serine incorporator 1
85
50475
5.91
3
2
2
1
2
0.06
0.09

DCUP_MOUSE
Uroporphyrinogen decarboxylase
85
40666
6.21
4
3
3
2
3
0.21
0.23

KINH_MOUSE
Kinesin-1 heavy chain
85
109484
6.06
11
5
8
3
8
0.13
0.12

KANK2_MOUSE
KN motif and ankyrin repeat domain-containing protein 2
85
90190
5.38
6
2
3
1
3
0.06
0.05

AGM1_MOUSE
Phosphoacetylglucosamine mutase
84
59415
5.8
3
2
3
2
3
0.14
0.15

USP9X_MOUSE
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
84
290526
5.57
8
1
5
1
5
0.04
0.01

ADDA_MOUSE
Alpha-adducin
84
80596
5.62
6
2
4
1
4
0.11
0.05

FA98B_MOUSE
Protein FAM98B
84
45321
8.77
3
2
3
2
3
0.15
0.2

GALK2_MOUSE
N-Acetylgalactosamine kinase
84
50470
6.47
10
4
6
3
6
0.38
0.39

UB2V1_MOUSE
Ubiquitin-conjugating enzyme E2 variant 1
84
16344
7.74
11
3
6
2
6
0.58
0.65

PPGB_MOUSE
Lysosomal protective protein
83
53809
5.56
9
3
8
3
8
0.27
0.26

EIF2A_MOUSE
Eukaryotic translation initiation factor 2A
83
64363
9.04
11
6
5
4
5
0.14
0.3

CATH_MOUSE
Pro-cathepsin H
83
37146
8.68
4
3
3
3
3
0.21
0.4

CD97_MOUSE
CD97 antigen
83
90354
7.38
2
2
1
1
1
0.03
0.05

RDH11_MOUSE
Retinol dehydrogenase 11
83
35125
9.1
10
6
5
3
5
0.24
0.43

QCR2_MOUSE
Cytochrome b-c1 complex subunit 2, mitochondrial
82
48205
9.26
14
5
7
2
7
0.37
0.19

ITPA_MOUSE
Inosine triphosphate pyrophosphatase
82
21883
5.6
5
2
2
1
2
0.15
0.21

TWF1_MOUSE
Twinfilin-1
82
40054
6.21
7
4
4
3
4
0.19
0.37

SEPT9_MOUSE
Septin-9
82
65534
9.01
16
5
9
3
9
0.23
0.21

PGFS_MOUSE
Prostamide/prostaglandin F synthase
81
21656
6.31
2
2
1
1
1
0.15
0.21

ECI1_MOUSE
Enoyl-CoA delta isomerase 1, mitochondrial
81
32230
9.12
3
3
2
2
2
0.13
0.29

RPE_MOUSE
Ribulose-phosphate 3-epimerase
81
24928
5.2
3
3
2
2
2
0.24
0.39

RL13_MOUSE
60S ribosomal protein L13
80
24290
11.54
18
6
7
4
6
0.32
0.97

RWDD1_MOUSE
RWD domain-containing protein 1
80
27768
4.18
4
2
2
1
2
0.23
0.16

CAN1_MOUSE
Calpain-1 catalytic subunit
80
82054
5.62
3
2
3
2
3
0.09
0.11

ECM29_MOUSE
Proteasome-associated protein ECM29 homolog
80
203573
6.68
10
4
7
4
7
0.08
0.09

ADA_MOUSE
Adenosine deaminase
80
39966
5.48
3
2
3
2
3
0.27
0.23

PSMD7_MOUSE
26S proteasome non-ATPase regulatory subunit 7
80
36517
6.29
5
3
5
3
5
0.34
0.41

RAGP1_MOUSE
Ran GTPase-activating protein 1
80
63491
4.59
8
5
5
4
5
0.15
0.3

ACON_MOUSE
Aconitate hydratase, mitochondrial
79
85410
8.08
10
4
9
4
9
0.2
0.22

NEB2_MOUSE
Neurabin-2
79
89466
4.86
5
2
4
2
4
0.13
0.1

IF2B_MOUSE
Eukaryotic translation initiation factor 2 subunit 2
79
38068
5.61
6
4
4
3
4
0.18
0.39

NXP20_MOUSE
Protein Noxp20
78
60975
4.49
6
3
4
2
4
0.11
0.15

ABCF1_MOUSE
ATP-binding cassette sub-family F member 1
78
94887
6.15
9
3
6
3
6
0.11
0.14

HEM3_MOUSE
Porphobilinogen deaminase
78
39320
6.41
4
2
3
1
3
0.17
0.11

CSN4_MOUSE
COP9 signalosome complex subunit 4
78
46256
5.57
6
4
5
3
5
0.2
0.31

C1TM_MOUSE
Monofunctional C1-tetrahydrofolate synthase, mitochondrial
78
105662
6.58
10
2
8
1
8
0.15
0.04

SPRE_MOUSE
Sepiapterin reductase
78
27865
5.58
2
2
2
2
2
0.12
0.35

PLCD1_MOUSE
1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
77
85819
5.82
3
2
1
1
1
0.02
0.05

IF2B2_MOUSE
Insulin-like growth factor 2 mRNA-binding protein 2
77
65543
7.81
3
2
3
2
3
0.07
0.14

MCAT_MOUSE
Mitochondrial carnitine/acylcarnitine carrier protein
77
33005
9.24
6
3
4
2
4
0.31
0.29

GSH0_MOUSE
Glutamate–cysteine ligase regulatory subunit
76
30516
5.35
6
2
5
2
5
0.32
0.31

HA1B_MOUSE
H-2 class I histocompatibility antigen, K-B alpha chain
76
41276
5.96
6
3
3
3
3
0.14
0.35

AR6P1_MOUSE
ADP-ribosylation factor-like protein 6-interacting protein 1
76
23421
9.38
3
2
2
1
2
0.19
0.19

TM9S2_MOUSE
Transmembrane 9 superfamily member 2
76
75280
7.21
6
3
5
2
5
0.14
0.12

SFXN1_MOUSE
Sideroflexin-1
76
35626
9.35
4
1
4
1
4
0.26
0.12

RS21_MOUSE
40S ribosomal protein S21
76
9136
8.71
7
3
4
1
4
0.54
0.56

IL4RA_MOUSE
Interleukin-4 receptor subunit alpha
76
87571
4.97
3
2
2
1
2
0.04
0.05

EIF1_MOUSE
Eukaryotic translation initiation factor 1
75
12739
6.89
3
2
2
2
2
0.24
0.89

NUCB1_MOUSE
Nucleobindin-1
75
53376
4.99
17
4
11
2
11
0.34
0.17

MMS19_MOUSE
MMS19 nucleotide excision repair protein homolog
75
113017
5.81
4
2
3
2
3
0.07
0.08

GCP60_MOUSE
Golgi resident protein GCP60
75
60144
5.07
12
5
5
2
5
0.2
0.15

FDFT_MOUSE
Squalene synthase
75
48123
5.91
9
3
6
2
6
0.27
0.3

TPD52_MOUSE
Tumor protein D52
75
24298
4.69
4
3
3
2
3
0.25
0.4

RBM3_MOUSE
RNA-binding protein 3
75
16595
6.84
14
7
5
4
5
0.57
1.68

RBMS1_MOUSE
RNA-binding motif, single-stranded-interacting protein 1
75
43963
8.79
3
2
3
2
3
0.21
0.21

NDUAA_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
75
40578
7.63
5
3
5
3
5
0.23
0.36

SRC8_MOUSE
Src substrate cortactin
75
61212
5.24
10
2
8
2
8
0.15
0.15

HNRPC_MOUSE
Heterogeneous nuclear ribonucleoproteins C1/C2
74
34364
4.92
2
1
2
1
2
0.09
0.13

CP20A_MOUSE
Cytochrome P450 20A1
74
52116
6.48
5
3
4
2
4
0.19
0.17

LDLR_MOUSE
Low-density lipoprotein receptor
74
94885
4.82
5
2
5
2
5
0.13
0.09

MARC2_MOUSE
Mitochondrial amidoxime reducing component 2
73
38170
8.95
2
2
2
2
2
0.15
0.24

ERF3A_MOUSE
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
73
68582
5.12
13
6
9
4
9
0.22
0.28

ALD2_MOUSE
Aldose reductase-related protein 2
73
36098
5.97
4
2
4
2
4
0.2
0.26

ADPRH_MOUSE
[Protein ADP-ribosylarginine] hydrolase
73
40042
5.46
3
2
3
2
3
0.22
0.23

ATP5I_MOUSE
ATP synthase subunit e, mitochondrial
72
8230
9.34
9
4
4
2
4
0.62
1.66

GLU2B_MOUSE
Glucosidase 2 subunit beta
72
58756
4.41
12
5
8
4
8
0.24
0.33

ACSL4_MOUSE
Long-chain-fatty-acid–CoA ligase 4
72
79026
8.57
12
5
8
3
6
0.19
0.17

PUF60_MOUSE
Poly(U)-binding-splicing factor PUF60
72
60211
5.2
6
2
5
1
5
0.24
0.07

PTPA_MOUSE
Serine/threonine-protein phosphatase 2A activator
72
36687
5.95
5
2
4
1
4
0.29
0.12

PDXK_MOUSE
Pyridoxal kinase
72
34993
5.88
4
2
4
2
4
0.19
0.27

AP1G1_MOUSE
AP-1 complex subunit gamma-1
71
91292
6.36
6
4
5
3
5
0.16
0.15

ATG3_MOUSE
Ubiquitin-like-conjugating enzyme ATG3
71
35773
4.63
4
2
3
1
3
0.28
0.26

KAP0_MOUSE
cAMP-dependent protein kinase type I-alpha regulatory subunit
71
43158
5.27
9
2
8
2
8
0.28
0.21

IF4B_MOUSE
Eukaryotic translation initiation factor 4B
71
68799
5.47
8
6
2
2
2
0.07
0.13

NPL4_MOUSE
Nuclear protein localization protein 4 homolog
71
67974
6.01
3
1
3
1
3
0.11
0.06

CX6A1_MOUSE
Cytochrome c oxidase subunit 6A1, mitochondrial
71
12344
9.97
3
2
2
1
2
0.45
0.39

CDC37_MOUSE
Hsp90 co-chaperone Cdc37
71
44565
5.24
6
4
5
3
5
0.21
0.32

AN32A_MOUSE
Acidic leucine-rich nuclear phosphoprotein 32 family member A
71
28520
3.99
4
2
4
2
4
0.22
0.34

PA24A_MOUSE
Cytosolic phospholipase A2
71
85168
5.28
6
2
6
2
6
0.18
0.1

CO5A2_MOUSE
Collagen alpha-2(V) chain
70
144929
6.28
17
7
9
5
9
0.14
0.16

ANXA7_MOUSE
Annexin A7
70
49893
5.91
10
3
8
2
8
0.22
0.18

AIF1L_MOUSE
Allograft inflammatory factor 1-like
70
17013
6.63
3
2
2
1
2
0.16
0.27

MECR_MOUSE
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
70
40317
9.17
3
3
1
1
1
0.09
0.11

MPI_MOUSE
Mannose-6-phosphate isomerase
70
46545
5.62
2
1
2
1
2
0.1
0.09

SUCB2_MOUSE
Succinate–CoA ligase [GDP-forming] subunit beta, mitochondrial
70
46811
6.58
4
1
4
1
4
0.14
0.09

MMAB_MOUSE
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
69
26256
9.32
2
1
2
1
2
0.16
0.17

AGAL_MOUSE
Alpha-galactosidase A
69
47611
5.44
4
2
4
2
4
0.14
0.19

SP16H_MOUSE
FACT complex subunit SPT16
69
119749
5.5
4
1
4
1
4
0.07
0.04

NP1L4_MOUSE
Nucleosome assembly protein 1-like 4
69
42653
4.56
9
3
7
3
5
0.32
0.34

UBQL1_MOUSE
Ubiquilin-1
69
61937
4.86
10
4
6
3
6
0.24
0.22

RET1_MOUSE
Retinol-binding protein 1
69
15836
5.1
4
2
4
2
4
0.44
0.68

ABHEB_MOUSE
Protein ABHD14B
69
22437
5.82
2
1
2
1
2
0.1
0.2

HM13_MOUSE
Minor histocompatibility antigen H13
69
41721
5.7
4
2
2
1
2
0.1
0.1

GALM_MOUSE
Aldose 1-epimerase
68
37775
6.26
4
2
3
2
3
0.13
0.25

AP3B1_MOUSE
AP-3 complex subunit beta-1
68
122664
5.49
13
3
9
3
9
0.11
0.11

LEG9_MOUSE
Galectin-9
68
40010
9.41
9
3
6
3
6
0.24
0.37

SPART_MOUSE
Spartin
68
72610
5.64
3
2
3
2
3
0.09
0.12

ERAP1_MOUSE
Endoplasmic reticulum aminopeptidase 1
67
106531
5.82
7
3
5
3
5
0.09
0.12

PIEZ1_MOUSE
Piezo-type mechanosensitive ion channel component 1
67
291813
7.41
2
1
2
1
2
0.01
0.01

AL1L2_MOUSE
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
67
101526
5.93
8
3
7
3
6
0.13
0.13

PDLI7_MOUSE
PDZ and LIM domain protein 7
67
50087
8.82
5
1
5
1
5
0.23
0.09

ADA15_MOUSE
Disintegrin and metalloproteinase domain-containing protein 15
67
92604
6.09
5
2
3
1
3
0.09
0.05

PGPI_MOUSE
Pyroglutamyl-peptidase 1
66
22919
5.21
4
3
4
3
4
0.43
0.72

ANTR1_MOUSE
Anthrax toxin receptor 1
66
62269
7.53
3
1
3
1
3
0.08
0.07

OSTF1_MOUSE
Osteoclast-stimulating factor 1
66
23768
5.46
4
2
4
2
4
0.3
0.42

IL1RA_MOUSE
Interleukin-1 receptor antagonist protein
66
20261
5.82
3
2
3
2
3
0.42
0.5

CC90B_MOUSE
Coiled-coil domain-containing protein 90B, mitochondrial
66
29578
8.54
3
1
3
1
3
0.25
0.15

PON2_MOUSE
Serum paraoxonase/arylesterase 2
66
39592
5.49
5
3
3
1
3
0.18
0.11

PGH1_MOUSE
Prostaglandin G/H synthase 1
66
68998
6.36
7
5
6
5
6
0.12
0.35

NRADD_MOUSE
Death domain-containing membrane protein NRADD
66
24711
4.89
2
2
1
1
1
0.14
0.18

PEA15_MOUSE
Astrocytic phosphoprotein PEA-15
66
15045
4.94
9
3
4
3
4
0.45
1.26

B2MG_MOUSE
Beta-2-microglobulin
66
13770
8.55
3
2
3
2
3
0.35
0.81

ACADM_MOUSE
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
66
46452
8.6
4
2
4
2
4
0.18
0.2

SCRB2_MOUSE
Lysosome membrane protein 2
65
54009
4.99
5
2
5
2
5
0.12
0.17

AATC_MOUSE
Aspartate aminotransferase, cytoplasmic
65
46219
6.68
14
3
10
3
10
0.34
0.31

ERO1A_MOUSE
ERO1-like protein alpha
65
54050
6.12
6
3
4
2
4
0.14
0.17

PUR8_MOUSE
Adenylosuccinate lyase
65
54831
6.9
6
3
5
2
5
0.19
0.16

LSG1_MOUSE
Large subunit GTPase 1 homolog
64
73111
6.08
5
2
4
1
4
0.1
0.06

NAGAB_MOUSE
Alpha-N-acetylgalactosaminidase
64
47204
6.02
4
2
3
1
3
0.14
0.09

IDHG1_MOUSE
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
64
42758
9.17
2
1
2
1
2
0.09
0.1

CTGF_MOUSE
Connective tissue growth factor
64
37798
8.22
14
6
8
3
8
0.33
0.39

EFTS_MOUSE
Elongation factor Ts, mitochondrial
64
35312
6.62
5
3
4
2
4
0.25
0.27

DBNL_MOUSE
Drebrin-like protein
64
48670
4.9
5
1
4
1
4
0.13
0.09

TENA_MOUSE
Tenascin
64
231659
4.77
11
3
8
2
8
0.09
0.04

SYTC_MOUSE
Threonine–tRNA ligase, cytoplasmic
64
83303
7.03
6
4
5
4
5
0.12
0.22

TMM59_MOUSE
Transmembrane protein 59
64
36290
4.8
2
1
2
1
2
0.12
0.12

ARK72_MOUSE
Aflatoxin B1 aldehyde reductase member 2
63
40586
8.36
2
2
1
1
1
0.1
0.11

PR2C3_MOUSE
Prolactin-2C3
63
25322
5.61
9
2
5
1
5
0.55
0.18

AL7A1_MOUSE
Alpha-aminoadipic semialdehyde dehydrogenase
62
58824
7.16
5
4
5
4
5
0.15
0.33

STAT1_MOUSE
Signal transducer and activator of transcription 1
49
87142
5.42
8
4
6
3
3
0.14
0.15

FMR1_MOUSE
Synaptic functional regulator FMR1
62
68947
7.27
7
2
6
2
5
0.17
0.13

EGFR_MOUSE
Epidermal growth factor receptor
59
134766
6.46
7
2
7
2
7
0.09
0.06

DCAKD_MOUSE
Dephospho-CoA kinase domain-containing protein
61
26459
9.61
4
2
3
1
3
0.2
0.17

TIM13_MOUSE
Mitochondrial import inner membrane translocase subunit Tim13
61
10451
8.42
6
2
2
1
2
0.26
0.47

ITAM_MOUSE
Integrin alpha-M
61
127400
6.87
4
2
3
1
3
0.04
0.03

ARP10_MOUSE
Actin-related protein 10
61
46178
7.54
2
2
2
2
2
0.05
0.2

TMED5_MOUSE
Transmembrane emp24 domain-containing protein 5
61
26155
4.81
5
2
4
2
4
0.31
0.37

TRXR1_MOUSE
Thioredoxin reductase 1, cytoplasmic
61
67042
7.42
9
6
7
5
7
0.22
0.37

NAGK_MOUSE
N-acetyl-D-glucosamine kinase
60
37245
5.43
5
3
3
2
3
0.23
0.25

GAPR1_MOUSE
Golgi-associated plant pathogenesis-related protein 1
60
17080
9.54
5
2
3
1
3
0.32
0.27

ODO2_MOUSE
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
60
48963
9.11
8
2
7
2
7
0.2
0.19

STX7_MOUSE
Syntaxin-7
60
29802
5.6
9
4
5
2
5
0.15
0.32

GID8_MOUSE
Glucose-induced degradation protein 8 homolog
60
26762
4.92
4
2
3
1
3
0.3
0.17

PGBM_MOUSE
Basement membrane-specific heparan sulfate proteoglycan core protein
60
398039
5.88
10
4
8
3
8
0.05
0.04

MDR1A_MOUSE
Multidrug resistance protein 1A
60
140558
8.94
4
1
3
1
3
0.04
0.03

CASP1_MOUSE
Caspase-1
59
45611
5.73
4
2
3
1
3
0.15
0.1

SYCC_MOUSE
Cysteine–tRNA ligase, cytoplasmic
59
94800
6.32
13
3
8
3
8
0.15
0.14

PRRX1_MOUSE
Paired mesoderm homeobox protein 1
59
27253
9.48
2
2
1
1
1
0.12
0.16

LY6A_MOUSE
Lymphocyte antigen 6A-2/6E-1
59
14367
4.75
4
3
1
1
1
0.16
0.33

AMPD3_MOUSE
AMP deaminase 3
59
88596
6.87
4
1
4
1
4
0.08
0.05

NDRG2_MOUSE
Protein NDRG2
59
40763
5.23
2
1
2
1
2
0.12
0.11

S39AE_MOUSE
Zinc transporter ZIP14
59
53927
5.11
1
1
1
1
1
0.06
0.08

PLPHP_MOUSE
Pyridoxal phosphate homeostasis protein
59
30030
8.37
4
4
4
4
4
0.33
0.74

PSMD3_MOUSE
26S proteasome non-ATPase regulatory subunit 3
59
60680
8.48
7
2
6
2
6
0.18
0.15

TRADD_MOUSE
Tumor necrosis factor receptor type 1-associated DEATH domain protein
59
34556
5.11
5
1
3
1
3
0.12
0.13

ANM5_MOUSE
Protein arginine N-methyltransferase 5
59
72634
5.99
5
3
3
2
3
0.13
0.12

IPO9_MOUSE
Importin-9
58
115978
4.71
6
2
4
2
4
0.09
0.07

VPS52_MOUSE
Vacuolar protein sorting-associated protein 52 homolog
58
81993
5.65
7
2
3
1
3
0.07
0.05

LRRF1_MOUSE
Leucine-rich repeat flightless-interacting protein 1
58
79201
4.75
2
1
2
1
2
0.08
0.05

E41L3_MOUSE
Band 4.1-like protein 3
58
103274
5.2
5
2
4
2
4
0.05
0.08

EMIL1_MOUSE
EMILIN-1
58
107518
5.21
3
1
3
1
3
0.06
0.04

EEA1_MOUSE
Early endosome antigen 1
58
160817
5.59
6
2
5
2
5
0.06
0.05

MESD_MOUSE
LRP chaperone MESD
58
25191
6.06
2
2
1
1
1
0.06
0.18

IMPCT_MOUSE
Protein IMPACT
57
36253
4.97
3
2
3
2
3
0.15
0.26

GUAA_MOUSE
GMP synthase [glutamine-hydrolyzing]
57
76675
6.29
4
2
3
1
3
0.11
0.06

GCSH_MOUSE
Glycine cleavage system H protein, mitochondrial
57
18625
4.78
3
3
1
1
1
0.22
0.55

VA0D1_MOUSE
V-type proton ATPase subunit d 1
57
40275
4.89
9
4
8
4
8
0.34
0.51

PUR2_MOUSE
Trifunctional purine biosynthetic protein adenosine-3
57
107436
6.25
6
3
5
2
5
0.1
0.08

GLOD4_MOUSE
Glyoxalase domain-containing protein 4
57
33296
5.28
2
2
2
2
2
0.17
0.28

WDR61_MOUSE
WD repeat-containing protein 61
57
33752
5.1
3
2
3
2
3
0.18
0.28

CUL5_MOUSE
Cullin-5
57
90916
7.86
10
2
6
1
6
0.17
0.05

NICA_MOUSE
Nicastrin
57
78443
5.75
5
2
4
2
4
0.06
0.11

FKB14_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP14
57
24236
5.66
4
2
3
2
3
0.24
0.41

PLEK_MOUSE
Pleckstrin
57
39876
8.53
3
2
3
2
3
0.19
0.23

LA_MOUSE
Lupus La protein homolog
57
47727
9.77
5
2
5
2
5
0.13
0.19

TPBG_MOUSE
Trophoblast glycoprotein
56
46422
6.36
5
2
5
2
5
0.18
0.2

ETHE1_MOUSE
Persulfide dioxygenase ETHE1, mitochondrial
56
27721
6.78
2
1
2
1
2
0.23
0.16

UBR4_MOUSE
E3 ubiquitin-protein ligase UBR4
56
571927
5.72
20
2
16
2
16
0.07
0.01

ACSA_MOUSE
Acetyl-coenzyme A synthetase, cytoplasmic
56
78811
6.19
4
2
3
1
3
0.09
0.05

PSA_MOUSE
Puromycin-sensitive aminopeptidase
56
103260
5.61
7
4
6
3
6
0.14
0.13

S10A4_MOUSE
Protein S100-A4
56
11714
5.23
4
2
2
1
2
0.23
0.41

P3H3_MOUSE
Prolyl 3-hydroxylase 3
55
81650
6.21
3
1
3
1
3
0.08
0.05

LMNA_MOUSE
Prelamin-A/C
55
74193
6.54
10
1
5
1
5
0.11
0.06

VAC14_MOUSE
Protein VAC14 homolog
54
87992
5.75
5
1
4
1
4
0.09
0.05

PYR1_MOUSE
CAD protein
54
243084
6
13
5
11
4
11
0.11
0.07

ABRAL_MOUSE
Costars family protein ABRACL
54
9025
5.52
4
1
3
1
3
0.57
0.56

CTND1_MOUSE
Catenin delta-1
54
104860
6.41
8
2
8
2
8
0.12
0.08

FKB15_MOUSE
FK506-binding protein 15
54
132878
4.98
4
2
3
1
3
0.06
0.03

ECE1_MOUSE
Endothelin-converting enzyme 1
54
87017
5.64
5
5
5
5
5
0.17
0.27

AT5F1_MOUSE
ATP synthase F(0) complex subunit B1, mitochondrial
54
28930
9.11
8
2
6
2
6
0.27
0.33

LDAH_MOUSE
Lipid droplet-associated hydrolase
54
37349
8.5
3
1
2
1
2
0.18
0.12

TNIK_MOUSE
Traf2 and NCK-interacting protein kinase
54
150274
6.82
9
2
7
1
7
0.07
0.03

EI2BA_MOUSE
Translation initiation factor eIF-2B subunit alpha
54
33795
8.48
4
3
2
1
2
0.1
0.13

VAPA_MOUSE
Vesicle-associated membrane protein-associated protein A
53
27837
8.59
9
2
6
2
6
0.36
0.35

DYLT3_MOUSE
Dynein light chain Tctex-type 3
53
12949
4.98
1
1
1
1
1
0.29
0.37

ZZEF1_MOUSE
Zinc finger ZZ-type and EF-hand domain-containing protein 1
53
328102
5.74
6
2
4
1
4
0.03
0.01

NDRG1_MOUSE
Protein NDRG1
53
42981
5.69
5
2
4
2
4
0.21
0.21

PDLI5_MOUSE
PDZ and LIM domain protein 5
53
63259
8.61
15
3
7
3
7
0.27
0.22

LIMA1_MOUSE
LIM domain and actin-binding protein 1
53
84008
6.18
10
2
7
2
7
0.12
0.1

NPC2_MOUSE
Epididymal secretory protein E1
53
16432
7.59
13
3
8
2
8
0.7
0.65

AN32B_MOUSE
Acidic leucine-rich nuclear phosphoprotein 32 family member B
53
31060
3.89
2
1
2
1
2
0.11
0.14

ERP44_MOUSE
Endoplasmic reticulum resident protein 44
53
46823
5.09
6
2
6
2
6
0.24
0.19

CBR2_MOUSE
Carbonyl reductase [NADPH] 2
53
25942
9.1
2
2
2
2
2
0.23
0.38

TNR12_MOUSE
Tumor necrosis factor receptor superfamily member 12A
53
13632
8.18
2
1
2
1
2
0.43
0.35

GGT5_MOUSE
Glutathione hydrolase 5 proenzyme
53
61635
8.76
3
1
3
1
3
0.13
0.07

AL3A2_MOUSE
Fatty aldehyde dehydrogenase
52
53936
8.59
2
2
2
2
2
0.09
0.17

MYDGF_MOUSE
Myeloid-derived growth factor
52
17971
6.3
5
2
2
1
2
0.12
0.26

FKBP4_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP4
52
51540
5.54
4
2
3
1
3
0.13
0.08

AL1L1_MOUSE
Cytosolic 10-formyltetrahydrofolate dehydrogenase
52
98647
5.64
9
2
7
2
6
0.17
0.09

TCP4_MOUSE
Activated RNA polymerase II transcriptional coactivator p15
52
14418
9.6
5
2
3
1
3
0.28
0.33

GLO2_MOUSE
Hydroxyacylglutathione hydrolase, mitochondrial
51
34062
7.66
4
2
2
1
2
0.14
0.28

PARK7_MOUSE
Protein/nucleic acid deglycase DJ-1
51
20008
6.32
12
5
6
4
6
0.6
1.28

DHSO_MOUSE
Sorbitol dehydrogenase
51
38225
6.56
1
1
1
1
1
0.03
0.11

TENS3_MOUSE
Tensin-3
51
155491
6.19
6
1
4
1
4
0.07
0.03

RSU1_MOUSE
Ras suppressor protein 1
51
31531
8.86
5
1
5
1
5
0.35
0.14

PAK2_MOUSE
Serine/threonine-protein kinase PAK 2
49
57894
5.57
5
3
4
2
4
0.14
0.15

HSBP1_MOUSE
Heat shock factor-binding protein 1
51
8605
4.11
3
2
2
1
2
0.58
0.59

TMX3_MOUSE
Protein disulfide-isomerase TMX3
51
51815
5.02
4
2
4
2
4
0.17
0.17

CREG1_MOUSE
Protein CREG1
51
24436
5.96
4
3
3
3
3
0.23
0.66

MRP1_MOUSE
Multidrug resistance-associated protein 1
50
171075
7.03
2
1
2
1
2
0.04
0.02

NU4M_MOUSE
NADH-ubiquinone oxidoreductase chain 4
50
51847
9.42
4
3
3
2
3
0.11
0.17

TIMP2_MOUSE
Metalloproteinase inhibitor 2
50
24312
7.45
6
2
6
2
6
0.5
0.4

NUP93_MOUSE
Nuclear pore complex protein Nup93
50
93222
5.5
5
2
5
2
5
0.09
0.09

TGBR3_MOUSE
Transforming growth factor beta receptor type 3
50
93769
5.65
7
4
4
2
4
0.1
0.14

RM46_MOUSE
39S ribosomal protein L46, mitochondrial
50
32112
6.93
4
1
3
1
3
0.14
0.14

SRXN1_MOUSE
Sulfiredoxin-1
50
14140
7.82
4
1
2
1
2
0.26
0.34

SYQ_MOUSE
Glutamine–tRNA ligase
50
87621
6.93
9
2
6
1
6
0.16
0.05

SORCN_MOUSE
Sorcin
50
21613
5.32
10
2
4
1
4
0.26
0.21

NDUA2_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
50
10909
10.02
3
2
1
1
1
0.14
0.45

NASP_MOUSE
Nuclear autoantigenic sperm protein
50
83903
4.35
4
2
4
2
4
0.1
0.1

A16A1_MOUSE
Aldehyde dehydrogenase family 16 member A1
49
84703
5.9
1
1
1
1
1
0.04
0.05

NQO1_MOUSE
NAD(P)H dehydrogenase [quinone] 1
49
30940
8.74
12
4
6
2
6
0.36
0.31

NRBP_MOUSE
Nuclear receptor-binding protein
49
59828
5.02
1
1
1
1
1
0.06
0.07

NIF3L_MOUSE
NIF3-like protein 1
49
41719
6.28
5
2
3
1
3
0.12
0.1

NDUS4_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
49
19772
10
3
1
3
1
2
0.26
0.23

CERS2_MOUSE
Ceramide synthase 2
49
44995
8.85
1
1
1
1
1
0.05
0.1

GT251_MOUSE
Procollagen galactosyltransferase 1
49
71015
6.83
11
4
9
4
9
0.28
0.27

S23IP_MOUSE
SEC23-interacting protein
49
110711
5.63
4
1
3
1
3
0.07
0.04

DDRGK_MOUSE
DDRGK domain-containing protein 1
49
35956
5.32
3
1
2
1
2
0.13
0.12

LMAN1_MOUSE
Protein ERGIC-53
49
57753
5.92
11
5
7
4
7
0.25
0.34

AHSA1_MOUSE
Activator of 90 kDa heat shock protein ATPase homolog 1
49
38093
5.41
5
2
5
2
5
0.27
0.24

HMGCL_MOUSE
Hydroxymethylglutaryl-CoA lyase, mitochondrial
48
34217
8.7
3
2
3
2
3
0.2
0.27

PURA2_MOUSE
Adenylosuccinate synthetase isozyme 2
48
49990
5.98
6
2
5
2
5
0.16
0.18

SYK_MOUSE
Lysine–tRNA ligase
48
67796
5.65
6
1
4
1
4
0.11
0.06

CGAT1_MOUSE
Chondroitin sulfate N-acetylgalactosaminyltransferase 1
48
60878
9.03
1
1
1
1
1
0.03
0.07

NSDHL_MOUSE
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
48
40660
7.71
6
4
4
3
4
0.19
0.36

KTN1_MOUSE
Kinectin
48
152498
5.67
11
1
11
1
11
0.12
0.03

BID_MOUSE
BH3-interacting domain death agonist
48
21938
4.71
2
2
2
2
2
0.15
0.46

DEGS1_MOUSE
Sphingolipid delta(4)-desaturase DES1
45
38216
7.33
2
2
2
2
2
0.1
0.24

EP15R_MOUSE
Epidermal growth factor receptor substrate 15-like 1
47
99248
4.86
8
2
6
1
6
0.17
0.04

ARL2_MOUSE
ADP-ribosylation factor-like protein 2
47
20851
5.67
1
1
1
1
1
0.14
0.22

NPC1_MOUSE
Niemann-Pick C1 protein
47
142791
5.44
5
2
4
2
4
0.06
0.06

WASC2_MOUSE
WASH complex subunit 2
47
145224
4.63
4
2
4
2
4
0.05
0.06

NPL_MOUSE
N-Acetylneuraminate lyase
47
35108
7.74
3
2
1
1
1
0.09
0.27

CD63_MOUSE
CD63 antigen
47
25749
6.69
4
2
4
2
4
0.23
0.38

GLRX3_MOUSE
Glutaredoxin-3
47
37754
5.42
12
3
11
3
11
0.6
0.39

DNJB4_MOUSE
DnaJ homolog subfamily B member 4
47
37758
8.7
2
1
2
1
2
0.08
0.12

DC1L2_MOUSE
Cytoplasmic dynein 1 light intermediate chain 2
46
54185
5.89
7
3
7
3
6
0.25
0.26

ULA1_MOUSE
NEDD8-activating enzyme E1 regulatory subunit
46
60236
5.34
6
3
4
2
4
0.16
0.23

SETD3_MOUSE
Histone-lysine N-methyltransferase setd3
44
67134
5.47
2
2
2
2
2
0.08
0.13

LXN_MOUSE
Latexin
46
25476
5.48
2
1
2
1
2
0.14
0.18

MPEG1_MOUSE
Macrophage-expressed gene 1 protein
46
78340
5.64
4
2
3
1
3
0.1
0.05

YKT6_MOUSE
Synaptobrevin homolog YKT6
46
22300
5.97
4
1
4
1
4
0.35
0.2

GSHR_MOUSE
Glutathione reductase, mitochondrial
46
53629
8.19
8
2
6
1
6
0.19
0.08

CP062_MOUSE
UPF0505 protein C16orf62 homolog
46
109007
6.97
3
1
3
1
3
0.06
0.04

SCMC1_MOUSE
Calcium-binding mitochondrial carrier protein SCaMC-1
46
52868
7.02
7
2
6
2
6
0.23
0.17

CO4A2_MOUSE
Collagen alpha-2(IV) chain
46
167220
8.75
4
1
4
1
4
0.04
0.03

RDH13_MOUSE
Retinol dehydrogenase 13
46
36441
9.02
2
1
2
1
2
0.08
0.12

DPP2_MOUSE
Dipeptidyl peptidase 2
46
56218
5.17
1
1
1
1
1
0.03
0.08

ATX10_MOUSE
Ataxin-10
46
53673
5.12
5
2
4
2
4
0.12
0.17

APMAP_MOUSE
Adipocyte plasma membrane-associated protein
45
46405
5.97
2
2
1
1
1
0.07
0.09

EFHD2_MOUSE
EF-hand domain-containing protein D2
45
26775
5.01
8
1
3
1
3
0.12
0.17

PEDF_MOUSE
Pigment epithelium-derived factor
45
46205
6.48
3
1
2
1
2
0.1
0.09

SODC_MOUSE
Superoxide dismutase [Cu-Zn]
45
15933
6.02
9
3
5
2
5
0.39
0.67

S38A2_MOUSE
Sodium-coupled neutral amino acid transporter 2
45
55467
8.05
4
2
4
2
4
0.16
0.16

NUP50_MOUSE
Nuclear pore complex protein Nup50
45
49455
5.94
3
1
3
1
3
0.16
0.09

CD44_MOUSE
CD44 antigen
45
85565
4.82
6
1
5
1
5
0.11
0.05

NDUS8_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
45
24023
5.89
1
1
1
1
1
0.04
0.19

STX2_MOUSE
Syntaxin-2
45
33157
5.98
2
1
1
1
1
0.11
0.13

TMED3_MOUSE
Transmembrane emp24 domain-containing protein 3
45
25449
5.62
3
2
2
2
2
0.16
0.38

VMP1_MOUSE
Vacuole membrane protein 1
45
45931
6.47
1
1
1
1
1
0.07
0.09

PRAF1_MOUSE
Prenylated Rab acceptor protein 1
45
20606
7.74
1
1
1
1
1
0.08
0.22

ARMC6_MOUSE
Armadillo repeat-containing protein 6
44
50651
5.65
2
1
2
1
2
0.12
0.09

GRHPR_MOUSE
Glyoxylate reductase/hydroxypyruvate reductase
44
35306
7.57
3
3
2
2
2
0.16
0.27

CRTAP_MOUSE
Cartilage-associated protein
44
46140
5.46
3
3
3
3
3
0.14
0.31

TM14C_MOUSE
Transmembrane protein 14C
44
11634
9.7
2
2
2
2
2
0.51
1.01

COX5B_MOUSE
Cytochrome c oxidase subunit 5B, mitochondrial
44
13804
8.69
10
4
3
2
3
0.34
0.81

NNRE_MOUSE
NAD(P)H-hydrate epimerase
44
30953
7.59
2
2
2
2
2
0.1
0.31

TPR_MOUSE
Nucleoprotein TPR
44
273824
4.98
10
1
10
1
10
0.06
0.02

SYFA_MOUSE
Phenylalanine–tRNA ligase alpha subunit
44
57563
8.27
3
1
2
1
2
0.05
0.08

E41L2_MOUSE
Band 4.1-like protein 2
43
109873
5.31
7
1
7
1
7
0.09
0.04

CBR3_MOUSE
Carbonyl reductase [NADPH] 3
43
30934
6.15
4
2
3
2
3
0.19
0.31

NDUB7_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
43
16320
8.35
5
2
2
2
2
0.26
0.65

LRN4L_MOUSE
LRRN4 C-terminal-like protein
43
25914
5.15
2
1
2
1
2
0.11
0.17

CSTFT_MOUSE
Cleavage stimulation factor subunit 2 tau variant
43
65820
6.78
4
1
3
1
3
0.13
0.07

RFA2_MOUSE
Replication protein A 32 kDa subunit
43
29700
5.76
1
1
1
1
1
0.09
0.15

NPS3B_MOUSE
Protein NipSnap homolog 3B
43
28290
9.51
2
2
1
1
1
0.1
0.16

HDAC7_MOUSE
Histone deacetylase 7
43
101224
7.11
2
1
2
1
2
0.07
0.04

PEX19_MOUSE
Peroxisomal biogenesis factor 19
43
32713
4.26
4
1
4
1
4
0.34
0.14

GALK1_MOUSE
Galactokinase
43
42268
5.17
7
2
5
2
5
0.21
0.22

DCTN1_MOUSE
Dynactin subunit 1
43
141588
5.66
7
2
6
2
6
0.08
0.06

OAS1A_MOUSE
2-5-Oligoadenylate synthase 1A
43
42402
8.3
2
1
2
1
2
0.08
0.1

FKBP3_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP3
43
25132
9.29
3
2
3
2
3
0.21
0.39

GIPC1_MOUSE
PDZ domain-containing protein GIPC1
43
36107
5.65
3
2
3
2
3
0.17
0.26

EMC3_MOUSE
ER membrane protein complex subunit 3
43
29960
6.33
3
1
3
1
3
0.17
0.15

MMSA_MOUSE
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
43
57878
8.29
2
1
2
1
2
0.06
0.07

PLXB2_MOUSE
Plexin-B2
43
206099
5.58
12
1
9
1
9
0.09
0.02

FADS3_MOUSE
Fatty acid desaturase 3
42
51436
7
1
1
1
1
1
0.07
0.08

FUND2_MOUSE
FUN14 domain-containing protein 2
42
16554
9.71
1
1
1
1
1
0.07
0.28

GPX7_MOUSE
Glutathione peroxidase 7
42
21048
8.42
3
1
3
1
3
0.28
0.22

MTX2_MOUSE
Metaxin-2
42
29739
5.44
2
1
2
1
2
0.16
0.15

HTR5A_MOUSE
HEAT repeat-containing protein 5A
42
219754
6.31
4
1
4
1
4
0.05
0.02

ALG11_MOUSE
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
42
55234
8.58
3
1
2
1
2
0.09
0.08

DHSD_MOUSE
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
42
17003
9.3
4
2
2
1
2
0.23
0.27

UBP19_MOUSE
Ubiquitin carboxyl-terminal hydrolase 19
42
150454
5.99
3
1
3
1
3
0.04
0.03

OSMR_MOUSE
Oncostatin-M-specific receptor subunit beta
42
110160
6.16
3
1
1
1
1
0.04
0.04

PGP_MOUSE
Glycerol-3-phosphate phosphatase
42
34519
5.21
3
1
2
1
2
0.2
0.13

DDR2_MOUSE
Discoidin domain-containing receptor 2
38
96420
5.31
3
2
2
2
2
0.05
0.09

F162A_MOUSE
Protein FAM162A
42
17713
9.9
3
1
3
1
3
0.25
0.26

ACOT9_MOUSE
Acyl-coenzyme A thioesterase 9, mitochondrial
41
50528
8.74
8
3
5
2
5
0.16
0.18

UCHL1_MOUSE
Ubiquitin carboxyl-terminal hydrolase isozyme L1
41
24822
5.14
4
2
3
1
3
0.22
0.18

TPP2_MOUSE
Tripeptidyl-peptidase 2
41
139790
6.13
9
3
7
3
7
0.11
0.09

HEXB_MOUSE
Beta-hexosaminidase subunit beta
41
61077
8.29
5
1
3
1
3
0.14
0.07

CDIPT_MOUSE
CDP-diacylglycerol–inositol 3-phosphatidyltransferase
41
23583
8.56
2
1
2
1
2
0.21
0.19

GAS6_MOUSE
Growth arrest-specific protein 6
41
74561
5.34
5
2
4
1
4
0.09
0.06

PIN1_MOUSE
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
41
18359
8.93
2
1
2
1
2
0.19
0.25

APOE_MOUSE
Apolipoprotein E
41
35844
5.56
1
1
1
1
1
0.06
0.12

SGMR1_MOUSE
Sigma nonopioid intracellular receptor 1
41
25234
5.56
1
1
1
1
1
0.15
0.18

RTRAF_MOUSE
RNA transcription, translation and transport factor protein
41
28135
6.4
4
1
3
1
3
0.21
0.16

TF_MOUSE
Tissue factor
41
32914
9.4
5
2
5
2
5
0.26
0.29

ERGI3_MOUSE
Endoplasmic reticulum-Golgi intermediate compartment protein 3
40
43181
6.02
3
2
2
1
2
0.17
0.21

LONM_MOUSE
Lon protease homolog, mitochondrial
40
105776
6.15
6
1
5
1
5
0.14
0.04

TXD17_MOUSE
Thioredoxin domain-containing protein 17
40
14006
4.72
3
1
2
1
2
0.19
0.34

DJC10_MOUSE
DnaJ homolog subfamily C member 10
40
90525
6.53
7
2
4
2
4
0.09
0.1

PML_MOUSE
Protein PML
40
98180
5.42
4
1
4
1
4
0.09
0.04

NAGA_MOUSE
N-Acetylglucosamine-6-phosphate deacetylase
40
43473
5.78
1
1
1
1
1
0.07
0.1

HGH1_MOUSE
Protein HGH1 homolog
40
42889
4.66
1
1
1
1
1
0.06
0.1

GLRX5_MOUSE
Glutaredoxin-related protein 5, mitochondrial
40
16282
6.1
2
1
2
1
2
0.14
0.29

IPO11_MOUSE
Importin-11
40
112344
5.14
3
1
3
1
3
0.07
0.04

T176A_MOUSE
Transmembrane protein 176A
40
26579
7.62
3
1
2
1
2
0.16
0.17

S10AD_MOUSE
Protein S100-A13
40
11151
5.89
2
1
2
1
2
0.23
0.44

PEX14_MOUSE
Peroxisomal membrane protein PEX14
40
41183
5.03
2
1
2
1
2
0.15
0.11

DHRS1_MOUSE
Dehydrogenase/reductase SDR family member 1
40
33983
8.66
6
2
5
2
5
0.28
0.28

MVD1_MOUSE
Diphosphomevalonate decarboxylase
40
44044
5.89
3
2
3
2
3
0.19
0.21

VCAM1_MOUSE
Vascular cell adhesion protein 1
40
81265
5.21
5
2
3
1
3
0.09
0.05

PRDX3_MOUSE
Thioredoxin-dependent peroxide reductase, mitochondrial
40
28109
7.15
7
2
6
2
6
0.39
0.34

PP14B_MOUSE
Protein phosphatase 1 regulatory subunit 14B
40
15947
4.74
2
1
2
1
2
0.33
0.29

BPNT1_MOUSE
3(2),5-Bisphosphate nucleotidase 1
39
33175
5.54
3
1
3
1
3
0.15
0.13

FAF2_MOUSE
FAS-associated factor 2
39
52438
5.35
6
1
4
1
4
0.23
0.08

TI8AB_MOUSE
Putative mitochondrial import inner membrane translocase subunit Tim8 A-B
39
11276
6.11
4
1
3
1
3
0.39
0.43

GBP2_MOUSE
Guanylate-binding protein 2
39
66697
5.56
3
1
3
1
3
0.14
0.06

ABCD3_MOUSE
ATP-binding cassette sub-family D member 3
39
75426
9.32
7
2
7
2
7
0.18
0.12

DPP9_MOUSE
Dipeptidyl peptidase 9
39
97939
6.18
3
2
2
1
2
0.05
0.04

MSMO1_MOUSE
Methylsterol monooxygenase 1
39
34750
7.29
2
1
1
1
1
0.1
0.13

TRNT1_MOUSE
CCA tRNA nucleotidyltransferase 1, mitochondrial
39
49864
8.65
3
2
2
1
2
0.07
0.09

RIPK3_MOUSE
Receptor-interacting serine/threonine-protein kinase 3
39
53289
7.22
8
3
6
3
6
0.17
0.26

ERGI1_MOUSE
Endoplasmic reticulum-Golgi intermediate compartment protein 1
39
32541
6.59
4
2
3
1
3
0.14
0.14

P2RX4_MOUSE
P2X purinoceptor 4
38
43410
8.29
2
2
1
1
1
0.07
0.1

FCGRN_MOUSE
IgG receptor FcRn large subunit p51
38
40067
5.2
2
2
2
2
2
0.1
0.23

NCF2_MOUSE
Neutrophil cytosol factor 2
38
59448
6.18
2
1
2
1
2
0.09
0.07

TOIP2_MOUSE
Torsin-1A-interacting protein 2
38
54463
4.75
2
1
2
1
2
0.12
0.08

DHB11_MOUSE
Estradiol 17-beta-dehydrogenase 11
38
32860
8.85
2
2
1
1
1
0.06
0.13

SGTA_MOUSE
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
38
34301
4.99
4
2
3
2
3
0.12
0.27

HEM2_MOUSE
Delta-aminolevulinic acid dehydratase
38
36000
6.32
1
1
1
1
1
0.06
0.12

CX7A2_MOUSE
Cytochrome c oxidase subunit 7A2, mitochondrial
38
9285
10.28
3
1
3
1
3
0.53
0.54

PSB8_MOUSE
Proteasome subunit beta type-8
38
30241
6.22
4
1
4
1
4
0.19
0.15

DECR_MOUSE
2,4-Dienoyl-CoA reductase, mitochondrial
36
36191
9.1
4
2
4
2
4
0.2
0.26

XPP1_MOUSE
Xaa-Pro aminopeptidase 1
37
69547
5.33
3
2
3
2
3
0.09
0.13

SYYC_MOUSE
Tyrosine–tRNA ligase, cytoplasmic
37
59068
6.57
6
1
6
1
6
0.16
0.07

FLOT1_MOUSE
Flotillin-1
37
47484
6.71
12
2
4
1
4
0.13
0.09

BAP31_MOUSE
B cell receptor-associated protein 31
37
27939
8.73
5
1
3
1
3
0.16
0.16

NECP2_MOUSE
Adaptin ear-binding coat-associated protein 2
37
28580
7.71
9
4
4
2
4
0.28
0.34

GINM1_MOUSE
Glycoprotein integral membrane protein 1
37
36056
5.45
1
1
1
1
1
0.05
0.12

ATG7_MOUSE
Ubiquitin-like modifier-activating enzyme ATG7
37
77470
5.97
5
1
5
1
5
0.12
0.06

MA2B2_MOUSE
Epididymis-specific alpha-mannosidase
37
115537
6.9
1
1
1
1
1
0.02
0.04

TB182_MOUSE
182 kDa tankyrase-1-binding protein
37
181714
4.8
5
1
4
1
4
0.04
0.02

PICAL_MOUSE
Phosphatidylinositol-binding clathrin assembly protein
37
71498
7.71
4
1
4
1
4
0.1
0.06

PELP1_MOUSE
Proline-, glutamic acid-, and leucine-rich protein 1
37
117995
4.31
2
1
2
1
2
0.05
0.04

ARHG7_MOUSE
Rho guanine nucleotide exchange factor 7
37
96995
6.35
5
1
3
1
3
0.09
0.04

RT11_MOUSE
28S ribosomal protein S11, mitochondrial
37
20196
10.77
2
1
2
1
2
0.18
0.23

ODP2_MOUSE
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
37
67899
8.81
7
1
5
1
5
0.13
0.06

NT5C_MOUSE
5(3)-Deoxyribonucleotidase, cytosolic type
37
23062
5.31
2
1
2
1
2
0.22
0.2

INF2_MOUSE
Inverted formin-2
37
138474
5.09
5
1
4
1
4
0.07
0.03

WIPI1_MOUSE
WD repeat domain phosphoinositide-interacting protein 1
37
48727
6.03
2
1
2
1
2
0.09
0.09

GPDM_MOUSE
Glycerol-3-phosphate dehydrogenase, mitochondrial
37
80902
6.17
7
2
5
2
5
0.11
0.11

ATP8_MOUSE
ATP synthase protein 8
36
7761
9.88
2
1
1
1
1
0.15
0.67

BST2_MOUSE
Bone marrow stromal antigen 2
36
19140
6.82
2
2
1
1
1
0.05
0.24

DERL2_MOUSE
Derlin-2
36
27621
6.73
1
1
1
1
1
0.13
0.16

IF4G2_MOUSE
Eukaryotic translation initiation factor 4 gamma 2
36
102041
6.7
6
1
6
1
6
0.1
0.04

FKBP7_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP7
36
24897
5.69
3
2
3
2
3
0.17
0.39

PLP2_MOUSE
Proteolipid protein 2
36
16597
6.69
4
3
1
1
1
0.08
0.28

RL29_MOUSE
60S ribosomal protein L29
36
17576
11.84
5
1
5
1
5
0.34
0.26

WASH1_MOUSE
WASH complex subunit 1
36
51627
5.33
2
1
2
1
2
0.12
0.08

SIAS_MOUSE
Sialic acid synthase
36
39998
6.61
6
1
5
1
5
0.23
0.11

RT28_MOUSE
28S ribosomal protein S28, mitochondrial
36
20508
9.1
1
1
1
1
1
0.13
0.22

FACE1_MOUSE
CAAX prenyl protease 1 homolog
36
54699
6.49
2
1
2
1
2
0.09
0.08

MEP50_MOUSE
Methylosome protein 50
36
36919
5.09
1
1
1
1
1
0.09
0.12

SCFD2_MOUSE
Sec1 family domain-containing protein 2; OS = Mus musculus, GN = Scfd2, PE = 1, SV = 1
36
74703
6.35
4
1
4
1
4
0.11
0.06

PTN9_MOUSE
Tyrosine-protein phosphatase nonreceptor type 9; OS = Mus musculus, GN = Ptpn9, PE = 1, SV = 2
36
67927
8.34
3
1
2
1
2
0.07
0.06

MXRA8_MOUSE
Matrix remodeling-associated protein 8; OS = Mus musculus, GN = Mxra8, PE = 1, SV = 1
36
49719
6.66
2
1
2
1
2
0.05
0.09

COASY_MOUSE
Bifunctional coenzyme A synthase; OS = Mus musculus, GN = Coasy, PE = 1, SV = 2
36
61985
6.61
4
2
3
2
3
0.13
0.14

PFD1_MOUSE
Prefoldin subunit 1; OS = Mus musculus, GN = Pfdn1, PE = 1, SV = 1
35
14246
7.93
5
2
2
1
2
0.17
0.33

COX7C_MOUSE
Cytochrome c oxidase subunit 7C, mitochondrial; OS = Mus musculus, GN = Cox7c, PE = 1, SV = 1
35
7328
11
2
1
1
1
1
0.33
0.72

ZCCHV_MOUSE
Zinc finger CCCH-type antiviral protein 1; OS = Mus musculus, GN = Zc3hav1, PE = 1, SV = 1
35
106619
8.59
4
1
4
1
4
0.11
0.04

ASC_MOUSE
Apoptosis-associated speck-like protein containing a CARD; OS = Mus musculus, GN = Pycard, PE = 1, SV = 1
35
21445
5.26
2
1
2
1
2
0.2
0.21

KCY_MOUSE
UMP-CMP kinase; OS = Mus musculus, GN = Cmpk1, PE = 1, SV = 1
35
22151
5.68
4
2
4
2
4
0.3
0.45

HINT1_MOUSE
Histidine triad nucleotide-binding protein 1; OS = Mus musculus, GN = Hint1, PE = 1, SV = 3
35
13768
6.36
6
1
1
1
1
0.11
0.35

ARSA_MOUSE
Arylsulfatase A; OS = Mus musculus, GN = Arsa, PE = 1, SV = 2
35
53714
5.5
2
1
2
1
2
0.15
0.08

MIC13_MOUSE
MICOS complex subunit MIC13; OS = Mus musculus, GN = Mic13, PE = 1, SV = 1
35
13365
8.68
2
1
2
1
2
0.27
0.36

NUCB2_MOUSE
Nucleobindin-2 OS = Mus musculus, GN = Nucb2, PE = 1, SV = 2
35
50273
5.05
8
2
6
1
6
0.2
0.09

CHMP5_MOUSE
Charged multivesicular body protein 5; OS = Mus musculus, GN = Chmp5, PE = 1, SV = 1
35
24560
4.65
5
1
2
1
2
0.2
0.18

HOME3_MOUSE
Homer protein homolog 3 OS = Mus musculus GN = Homer3 PE = 1 SV = 2
35
39670
5.33
1
1
1
1
1
0.04
0.11

NHLC3_MOUSE
NHL repeat-containing protein 3; OS = Mus musculus, GN = Nhlrc3, PE = 1, SV = 1
34
38171
5.81
1
1
1
1
1
0.03
0.11

CTBP2_MOUSE
C-terminal-binding protein 2; OS = Mus musculus, GN = Ctbp2, PE = 1, SV = 2
34
48926
6.47
1
1
1
1
1
0.07
0.09

NU160_MOUSE
Nuclear pore complex protein Nup160; OS = Mus musculus, GN = Nup160, PE = 1, SV = 2
34
158130
5.32
5
1
4
1
4
0.04
0.03

RAB34_MOUSE
Ras-related protein Rab-34; OS = Mus musculus, GN = Rab34, PE = 1, SV = 2
34
29082
8.55
6
2
4
2
4
0.22
0.33

COMD8_MOUSE
COMM domain-containing protein 8; OS = Mus musculus, GN = Commd8, PE = 1, SV = 1
34
20839
5.38
2
1
2
1
2
0.3
0.22

HECD1_MOUSE
E3 ubiquitin-protein ligase HECTD1; OS = Mus musculus, GN = Hectd1, PE = 1, SV = 2
34
289905
5.26
12
1
11
1
11
0.08
0.01

LYRIC_MOUSE
Protein LYRIC; OS = Mus musculus, GN = Mtdh, PE = 1, SV = 1
34
63808
9.34
5
3
4
3
4
0.2
0.22

S35F6_MOUSE
Solute carrier family 35 member F6; OS = Mus musculus, GN = Slc35f6, PE = 1, SV = 1
34
40952
6.65
2
1
2
1
2
0.17
0.11

SBDS_MOUSE
Ribosome maturation protein SBDS; OS = Mus musculus, GN = Sbds, PE = 1, SV = 4
34
28762
8.92
2
1
1
1
1
0.09
0.15

RHG01_MOUSE
Rho GTPase-activating protein 1; OS = Mus musculus, GN = Arhgap1, PE = 1, SV = 1
34
50379
5.97
5
3
3
3
3
0.12
0.28

FACR1_MOUSE
Fatty acyl-CoA reductase 1; OS = Mus musculus, GN = Far1, PE = 1, SV = 1
34
59397
9.26
4
1
2
1
2
0.09
0.07

MPRD_MOUSE
Cation-dependent mannose-6-phosphate receptor; OS = Mus musculus, GN = M6pr, PE = 1, SV = 1
33
31152
5.24
3
2
2
1
2
0.13
0.14

PNKP_MOUSE
Bifunctional polynucleotide phosphatase/kinase; OS = Mus musculus, GN = Pnkp, PE = 1, SV = 2
33
57188
8.03
9
1
5
1
5
0.15
0.08

DCPS_MOUSE
m7GpppX diphosphatase; OS = Mus musculus, GN = Dcps, PE = 1, SV = 1
33
38964
6.02
2
1
2
1
2
0.1
0.11

DHX29_MOUSE
ATP-dependent RNA helicase DHX29; OS = Mus musculus, GN = Dhx29, PE = 1, SV = 1
33
153879
8.13
11
2
9
1
9
0.1
0.03

CN37_MOUSE
2,3-Cyclic-nucleotide 3-phosphodiesterase; OS = Mus musculus, GN = Cnp, PE = 1, SV = 3
33
47094
9.08
1
1
1
1
1
0.07
0.09

TBCB_MOUSE
Tubulin-folding cofactor B; OS = Mus musculus, GN = Tbcb, PE = 1, SV = 2
33
27368
5.14
3
1
3
1
3
0.23
0.16

SFPQ_MOUSE
Splicing factor, proline- and glutamine-rich; OS = Mus musculus, GN = Sfpq, PE = 1, SV = 1
33
75394
9.45
3
1
2
1
2
0.07
0.06

GLYG_MOUSE
Glycogenin-1; OS = Mus musculus, GN = Gyg1, PE = 1, SV = 3
33
37378
5.06
2
1
2
1
2
0.12
0.12

TSPO_MOUSE
Translocator protein; OS = Mus musculus, GN = Tspo, PE = 1, SV = 1
33
18829
9.52
2
1
2
1
2
0.3
0.24

CND1_MOUSE
Condensin complex subunit 1; OS = Mus musculus, GN = Ncapd2, PE = 1, SV = 2
33
155567
5.98
4
1
3
1
3
0.04
0.03

JIP4_MOUSE
C-Jun-amino-terminal kinase-interacting protein 4; OS = Mus musculus, GN = Spag9, PE = 1, SV = 2
33
146129
5.05
6
1
6
1
6
0.08
0.03

NDUB9_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; OS = Mus musculus, GN = Ndufb9, PE = 1, SV = 3
33
21970
7.67
2
2
1
1
1
0.16
0.21

RBGP1_MOUSE
Rab GTPase-activating protein 1; OS = Mus musculus, GN = Rabgap1, PE = 1, SV = 1
32
120722
5.14
5
1
3
1
3
0.03
0.04

F13A_MOUSE
Coagulation factor XIII A chain; OS = Mus musculus, GN = F13a1, PE = 1, SV = 3
32
83155
5.63
4
3
2
2
2
0.06
0.11

DOCK7_MOUSE
Dedicator of cytokinesis protein 7; OS = Mus musculus, GN = Dock7, PE = 1, SV = 3
32
241286
6.25
6
1
6
1
6
0.04
0.02

IC1_MOUSE
Plasma protease C1 inhibitor; OS = Mus musculus, GN = Serping1, PE = 1, SV = 3
32
55549
5.87
2
1
2
1
2
0.13
0.08

SRP54_MOUSE
Signal recognition particle 54 kDa protein; OS = Mus musculus, GN = Srp54, PE = 1, SV = 2
32
55684
8.87
15
3
10
3
10
0.38
0.25

YIF1B_MOUSE
Protein YIF1B; OS = Mus musculus, GN = Yif1b, PE = 1, SV = 2
32
33961
9.19
5
1
2
1
2
0.14
0.13

TPC13_MOUSE
Trafficking protein particle complex subunit 13; OS = Mus musculus, GN = Trappc13, PE = 2, SV = 1
32
46446
5.33
3
1
2
1
2
0.12
0.09

MCL1_MOUSE
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; OS = Mus musculus, GN = Mcl1, PE = 1, SV = 3
32
35195
5.88
1
1
1
1
1
0.06
0.13

FPRP_MOUSE
Prostaglandin F2 receptor negative regulator; OS = Mus musculus, GN = Ptgfrn, PE = 1, SV = 2
32
98660
6.16
4
1
2
1
2
0.04
0.04

SPT5H_MOUSE
Transcription elongation factor SPT5; OS = Mus musculus, GN = Supt5h, PE = 1, SV = 1
32
120589
4.93
4
1
4
1
4
0.06
0.04

GPX8_MOUSE
Probable glutathione peroxidase 8; OS = Mus musculus, GN = Gpx8, PE = 1, SV = 1
32
24133
9.42
2
1
2
1
2
0.11
0.19

COR1C_MOUSE
Coronin-1C; OS = Mus musculus, GN = Coro1c, PE = 1, SV = 2
32
53087
6.65
6
1
4
1
4
0.18
0.08

T126A_MOUSE
Transmembrane protein 126A; OS = Mus musculus, GN = Tmem126a, PE = 1, SV = 1
32
21526
9.45
1
1
1
1
1
0.09
0.21

TBD2B_MOUSE
TBC1 domain family member 2B; OS = Mus musculus, GN = Tbc1d2b, PE = 1, SV = 2
32
109881
5.74
3
1
3
1
3
0.05
0.04

NDUA9_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; OS = Mus musculus, GN = Ndufa9, PE = 1, SV = 2
31
42498
9.75
2
1
2
1
2
0.07
0.1

GLMP_MOUSE
Glycosylated lysosomal membrane protein; OS = Mus musculus, GN = Glmp, PE = 1, SV = 1
31
43776
5.73
2
1
2
1
2
0.1
0.1

PEF1_MOUSE
Peflin; OS = Mus musculus, GN = Pef1, PE = 1, SV = 1
31
29209
5.89
3
1
2
1
2
0.15
0.15

TGM2_MOUSE
Protein-glutamine gamma-glutamyltransferase 2; OS = Mus musculus, GN = Tgm2, PE = 1, SV = 4
31
77012
4.98
3
1
3
1
3
0.05
0.06

STXB3_MOUSE
Syntaxin-binding protein 3; OS = Mus musculus, GN = Stxbp3, PE = 1, SV = 1
31
67899
8.28
1
1
1
1
1
0.03
0.06

APEH_MOUSE
Acylamino-acid-releasing enzyme; OS = Mus musculus, GN = Apeh, PE = 1, SV = 3
31
81529
5.36
5
2
5
2
5
0.14
0.11

UFSP2_MOUSE
Ufm1-specific protease 2; OS = Mus musculus, GN = Ufsp2, PE = 1, SV = 1
31
52482
6.28
1
1
1
1
1
0.05
0.08

CD166_MOUSE
CD166 antigen; OS = Mus musculus, GN = Alcam, PE = 1, SV = 3
31
65051
5.85
4
1
3
1
3
0.1
0.07

HIG1A_MOUSE
HIG1 domain family member 1A, mitochondrial; OS = Mus musculus, GN = Higd1a, PE = 1, SV = 1
31
10418
9.79
1
1
1
1
1
0.23
0.47

CYTB_MOUSE
Cystatin-B; OS = Mus musculus, GN = Cstb, PE = 1, SV = 1
31
11039
6.82
7
2
3
2
3
0.21
1.09

TIMP1_MOUSE
Metalloproteinase inhibitor 1; OS = Mus musculus, GN = Timp1, PE = 1, SV = 2
31
22613
9.14
3
1
3
1
3
0.27
0.2

SNP29_MOUSE
Synaptosomal-associated protein 29; OS = Mus musculus, GN = Snap29, PE = 1, SV = 1
31
29554
5.23
1
1
1
1
1
0.04
0.15

CDV3_MOUSE
Protein CDV3; OS = Mus musculus, GN = Cdv3, PE = 1, SV = 2
30
29711
5.84
2
1
2
1
2
0.22
0.15

FUBP1_MOUSE
Far upstream element-binding protein 1; OS = Mus musculus, GN = Fubp1, PE = 1, SV = 1
30
68497
7.74
5
1
4
1
4
0.1
0.06

FEN1_MOUSE
Flap endonuclease 1; OS = Mus musculus, GN = Fen1, PE = 1, SV = 1
30
42288
8.54
1
1
1
1
1
0.07
0.1

AAAT_MOUSE
Neutral amino acid transporter B(0); OS = Mus musculus, GN = Slc1a5, PE = 1, SV = 2
30
58445
8.14
5
1
4
1
4
0.08
0.07

EMB_MOUSE
Embigin; OS = Mus musculus, GN = Emb, PE = 1, SV = 2
30
37041
5.7
1
1
1
1
1
0.03
0.12

S2611_MOUSE
Sodium-independent sulfate anion transporter; OS = Mus musculus, GN = Slc26a11, PE = 2, SV = 2
30
64068
7.56
1
1
1
1
1
0.05
0.07

BIEA_MOUSE
Biliverdin reductase A; OS = Mus musculus, GN = Blvra, PE = 1, SV = 1
30
33504
6.53
4
1
3
1
3
0.19
0.13

TPD54_MOUSE
Tumor protein D54 OS = Mus musculus GN = Tpd52l2 PE = 1 SV = 1
30
24028
5.8
2
1
2
1
2
0.18
0.19

SHIP2_MOUSE
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; OS = Mus musculus, GN = Inppl1, PE = 1, SV = 1
30
138887
6.11
4
1
4
1
3
0.05
0.03

LTOR5_MOUSE
Ragulator complex protein LAMTOR5; OS = Mus musculus, GN = Lamtor5, PE = 1, SV = 1
30
9636
4.69
2
1
2
1
2
0.44
0.52

ZNT7_MOUSE
Zinc transporter 7; OS = Mus musculus, GN = Slc30a7, PE = 1, SV = 1
28
41763
6.33
5
2
4
2
4
0.19
0.22

COX6C_MOUSE
Cytochrome c oxidase subunit 6C; OS = Mus musculus, GN = Cox6c, PE = 1, SV = 3
30
8464
10.13
2
1
2
1
2
0.33
0.61

DRG2_MOUSE
Developmentally-regulated GTP-binding protein 2; OS = Mus musculus, GN = Drg2, PE = 1, SV = 1
29
40692
9.03
2
2
2
2
2
0.16
0.23

DYST_MOUSE
Dystonin; OS = Mus musculus, GN = Dst, PE = 1, SV = 2
29
833701
5.2
22
2
22
2
22
0.05
0.01

PSMG1_MOUSE
Proteasome assembly chaperone 1; OS = Mus musculus, GN = Psmg1, PE = 1, SV = 1
29
33083
6.05
4
2
2
2
2
0.15
0.29

FBN1_MOUSE
Fibrillin-1; OS = Mus musculus, GN = Fbn1, PE = 1, SV = 2
29
312083
4.8
27
1
24
1
24
0.19
0.01

DAG1_MOUSE
Dystroglycan; OS = Mus musculus, GN = Dag1, PE = 1, SV = 4
29
96844
8.59
4
1
3
1
3
0.04
0.04

SNX5_MOUSE
Sorting nexin-5; OS = Mus musculus, GN = Snx5, PE = 1, SV = 1
29
46768
6.19
5
1
5
1
5
0.17
0.09

TIM8B_MOUSE
Mitochondrial import inner membrane translocase subunit Tim8 B; OS = Mus musculus, GN = Timm8b, PE = 1, SV = 1
29
9281
5.02
1
1
1
1
1
0.13
0.54

PLCB3_MOUSE
1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; OS = Mus musculus, GN = Plcb3, PE = 1, SV = 2
29
139400
5.7
6
1
6
1
6
0.09
0.03

RTCB_MOUSE
tRNA-splicing ligase RtcB homolog; OS = Mus musculus, GN = Rtcb, PE = 1, SV = 1
28
55214
6.77
5
2
4
2
4
0.19
0.16

TM9S4_MOUSE
Transmembrane 9 superfamily member 4; OS = Mus musculus, GN = Tm9sf4, PE = 1, SV = 1
28
74644
6.86
1
1
1
1
1
0.03
0.06

MBOA7_MOUSE
Lysophospholipid acyltransferase 7; OS = Mus musculus, GN = Mboat7, PE = 1, SV = 1
28
53400
8.96
2
1
1
1
1
0.05
0.08

ARPC3_MOUSE
Actin-related protein 2/3 complex subunit 3; OS = Mus musculus, GN = Arpc3, PE = 1, SV = 3
28
20511
8.78
3
1
3
1
3
0.24
0.22

RL27A_MOUSE
60S ribosomal protein L27a; OS = Mus musculus, GN = Rpl27a, PE = 1, SV = 5
28
16595
11.12
11
2
4
1
4
0.29
0.28

JAK1_MOUSE
Tyrosine-protein kinase JAK1; OS = Mus musculus, GN = Jak1, PE = 1, SV = 1
28
133282
7.63
10
2
6
2
6
0.08
0.06

TBL1R_MOUSE
F-box-like/WD repeat-containing protein TBL1XR1; OS = Mus musculus, GN = Tbl1xr1, PE = 1, SV = 1
28
55626
5.33
4
1
2
1
2
0.1
0.08

PIPNA_MOUSE
Phosphatidylinositol transfer protein alpha isoform; OS = Mus musculus, GN = Pitpna, PE = 1, SV = 2
28
31873
5.97
2
1
2
1
2
0.13
0.14

GLGB_MOUSE
1,4-Alpha-glucan-branching enzyme; OS = Mus musculus, GN = Gbe1, PE = 1, SV = 1
28
80313
5.97
2
2
1
1
1
0.02
0.05

CY24B_MOUSE
Cytochrome b-245 heavy chain; OS = Mus musculus, GN = Cybb, PE = 1, SV = 1
27
65262
7.83
1
1
1
1
1
0.05
0.07

SNX7_MOUSE
Sorting nexin-7; OS = Mus musculus, GN = Snx7, PE = 1, SV = 1
27
44971
4.99
3
2
2
1
2
0.14
0.1

CSN8_MOUSE
COP9 signalosome complex subunit 8; OS = Mus musculus, GN = Cops8, PE = 1, SV = 1
27
23241
5.09
3
1
3
1
3
0.38
0.19

MTNA_MOUSE
Methylthioribose-1-phosphate isomerase; OS = Mus musculus, GN = Mri1, PE = 1, SV = 1
27
39386
5.6
3
2
3
2
3
0.25
0.23

SIR2_MOUSE
NAD-dependent protein deacetylase sirtuin-2; OS = Mus musculus, GN = Sirt2, PE = 1, SV = 2
27
43228
5.23
1
1
1
1
1
0.06
0.1

QCR7_MOUSE
Cytochrome b-c1 complex subunit 7 OS = Mus musculus, GN = Uqcrb, PE = 1, SV = 3
27
13519
9.1
2
1
2
1
2
0.21
0.35

ERBIN_MOUSE
Erbin; OS = Mus musculus, GN = Erbin, PE = 1, SV = 3
27
157150
5.46
4
1
4
1
4
0.05
0.03

TTL12_MOUSE
Tubulin–tyrosine ligase-like protein 12; OS = Mus musculus, GN = Ttll12, PE = 1, SV = 1
27
73996
5.39
3
1
2
1
2
0.07
0.06

FBLN3_MOUSE
EGF-containing fibulin-like extracellular matrix protein 1
27
54916
5.01
4
1
3
1
3
0.1
0.08

PYRD_MOUSE
Dihydroorotate dehydrogenase (quinone), mitochondrial
27
42674
9.56
1
1
1
1
1
0.06
0.1

COMD2_MOUSE
COMM domain-containing protein 2
26
22834
6.14
3
1
3
1
3
0.28
0.2

CBR1_MOUSE
Carbonyl reductase [NADPH] 1
26
30622
8.53
2
1
2
1
2
0.07
0.14

CTL1_MOUSE
Choline transporter-like protein 1
26
73018
9.04
4
1
4
1
4
0.06
0.06

CD47_MOUSE
Leukocyte surface antigen CD47
26
33076
8.93
2
1
2
1
2
0.14
0.13

DJC24_MOUSE
DnaJ homolog subfamily C member 24
26
22066
5.63
2
1
2
1
2
0.17
0.21

ACOD2_MOUSE
Acyl-CoA desaturase 2
26
40890
9.14
2
1
2
1
2
0.13
0.11

PROS_MOUSE
Vitamin K-dependent protein S
26
74886
5.61
8
1
5
1
5
0.11
0.06

TTYH2_MOUSE
Protein tweety homolog 2
26
58969
5.67
2
1
2
1
2
0.05
0.07

IF2P_MOUSE
Eukaryotic translation initiation factor 5B
26
137532
5.47
10
2
9
2
9
0.14
0.06

MCA3_MOUSE
Eukaryotic translation elongation factor 1 epsilon-1
26
19846
8.6
1
1
1
1
1
0.06
0.23

TM214_MOUSE
Transmembrane protein 214
26
76381
9.41
5
1
5
1
5
0.16
0.06

S10AA_MOUSE
Protein S100-A10
26
11179
6.27
4
1
1
1
1
0.27
0.44

ARAP1_MOUSE
Arf-GAP with Rho-GAP domain, ANK repeat and pH domain-containing protein 1
25
162174
5.81
2
1
2
1
2
0.03
0.03

LMF2_MOUSE
Lipase maturation factor 2
25
79947
9.99
1
1
1
1
1
0.02
0.05

OLR1_MOUSE
Oxidized low-density lipoprotein receptor 1
25
41617
7.55
2
1
2
1
2
0.09
0.11

UCRI_MOUSE
Cytochrome b-c1 complex subunit Rieske, mitochondrial
25
29349
8.91
2
2
1
1
1
0.09
0.15

MPPA_MOUSE
Mitochondrial-processing peptidase subunit alpha
25
58242
6.36
2
1
2
1
2
0.06
0.07

ARFG1_MOUSE
ADP-ribosylation factor GTPase-activating protein 1
25
45260
5.39
2
1
2
1
2
0.08
0.1

UBP24_MOUSE
Ubiquitin carboxyl-terminal hydrolase 24
25
293814
5.82
4
1
4
1
4
0.03
0.01

AIMP1_MOUSE
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
25
33976
8.57
3
1
2
1
2
0.15
0.13

STX17_MOUSE
Syntaxin-17
25
33201
6.28
2
1
2
1
2
0.15
0.13

TM165_MOUSE
Transmembrane protein 165
25
34768
6.97
7
1
3
1
3
0.25
0.13

ACOT2_MOUSE
Acyl-coenzyme A thioesterase 2, mitochondrial
25
49626
6.88
1
1
1
1
1
0.06
0.09

SPD2B_MOUSE
SH3 and PX domain-containing protein 2B
25
101454
8.78
3
1
3
1
3
0.07
0.04

VP13C_MOUSE
Vacuolar protein sorting-associated protein 13C
25
419824
6.37
10
1
8
1
8
0.04
0.01

LAP2B_MOUSE
Lamina-associated polypeptide 2, isoforms beta/delta/epsilon/gamma
25
50342
9.45
7
1
7
1
7
0.24
0.09

T106A_MOUSE
Transmembrane protein 106A
25
29091
7.07
5
1
2
1
2
0.16
0.15

NRP2_MOUSE
Neuropilin-2
24
104565
5.07
2
1
2
1
2
0.04
0.04

VISTA_MOUSE
V-type immunoglobulin domain-containing suppressor of T cell activation
24
33538
7.21
2
1
1
1
1
0.04
0.13

LYPA1_MOUSE
Acyl-protein thioesterase 1
24
24671
6.14
2
1
1
1
1
0.17
0.18

RIOK3_MOUSE
Serine/threonine-protein kinase RIO3
24
58667
5.47
4
1
3
1
3
0.09
0.07

RFA1_MOUSE
Replication protein A 70 kDa DNA-binding subunit
24
68994
8.13
5
1
4
1
4
0.11
0.06

SRRM1_MOUSE
Serine/arginine repetitive matrix protein 1
24
106798
11.87
8
1
6
1
6
0.12
0.04

GVIN1_MOUSE
Interferon-induced very large GTPase 1
24
280637
6.12
5
1
5
1
5
0.03
0.02

INO1_MOUSE
Inositol-3-phosphate synthase 1
24
60893
5.99
3
1
3
1
3
0.1
0.07

ADAS_MOUSE
Alkyldihydroxyacetonephosphate synthase, peroxisomal
24
71638
7.25
2
1
2
1
2
0.06
0.06

CASP3_MOUSE
Caspase-3
24
31454
6.45
3
1
3
1
3
0.18
0.14

RIDA_MOUSE
2-Iminobutanoate/2-iminopropanoate deaminase
24
14247
8.74
4
2
2
1
2
0.19
0.33

ARFG2_MOUSE
ADP-ribosylation factor GTPase-activating protein 2
24
56563
8.36
3
1
3
1
3
0.14
0.08

DHC24_MOUSE
Delta(24)-sterol reductase
24
60073
8.42
8
1
7
1
7
0.2
0.07

RT16_MOUSE
28S ribosomal protein S16, mitochondrial
24
15182
9.74
1
1
1
1
1
0.15
0.31

PTH_MOUSE
Probable peptidyl-tRNA hydrolase
24
22147
9.92
1
1
1
1
1
0.1
0.2

SWP70_MOUSE
Switch-associated protein 70
23
68953
5.78
2
1
2
1
2
0.07
0.06

VWA8_MOUSE
von Willebrand factor A domain-containing protein 8
23
213287
6.14
8
1
7
1
7
0.08
0.02

UBXN4_MOUSE
UBX domain-containing protein 4
23
56437
6.23
5
1
4
1
4
0.23
0.08

AEBP1_MOUSE
Adipocyte enhancer-binding protein 1
23
128284
5.02
6
1
5
1
5
0.09
0.03

GCR_MOUSE
Glucocorticoid receptor
23
85998
5.99
8
1
7
1
7
0.1
0.05

IAH1_MOUSE
Isoamyl acetate-hydrolyzing esterase 1 homolog
23
27956
5.34
3
1
2
1
2
0.12
0.16

VPS16_MOUSE
Vacuolar protein sorting-associated protein 16 homolog
22
94868
6.56
6
2
5
1
5
0.1
0.05

LY6C1_MOUSE
Lymphocyte antigen 6C1
22
14183
5.76
2
1
2
1
2
0.29
0.33

BCAT1_MOUSE
Branched-chain-amino-acid aminotransferase, cytosolic
22
42764
5.25
3
1
3
1
3
0.12
0.1

E2AK2_MOUSE
Interferon-induced, double-stranded RNA-activated protein kinase
22
58243
8.76
1
1
1
1
1
0.05
0.07

FLII_MOUSE
Protein flightless-1 homolog
21
144712
5.75
9
1
9
1
9
0.1
0.03

CHCH2_MOUSE
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
21
15651
9.78
2
1
2
1
2
0.24
0.3

TNPO2_MOUSE
Transportin-2
21
100391
4.85
7
1
6
1
4
0.14
0.04

UBFD1_MOUSE
Ubiquitin domain-containing protein UBFD1
21
40118
8.98
7
1
4
1
4
0.2
0.11

WWOX_MOUSE
WW domain-containing oxidoreductase
21
46483
6.54
2
1
2
1
2
0.11
0.09

DYR_MOUSE
Dihydrofolate reductase
21
21592
8.56
3
1
2
1
2
0.23
0.21

ARHG1_MOUSE
Rho guanine nucleotide exchange factor 1
21
102741
5.43
3
1
3
1
3
0.06
0.04

ATX2L_MOUSE
Ataxin-2-like protein
20
110580
8.94
2
1
2
1
2
0.05
0.04

PSD10_MOUSE
26S proteasome non-ATPase regulatory subunit 10
20
25068
5.68
1
1
1
1
1
0.06
0.18

TMF1_MOUSE
TATA element modulatory factor
20
121729
4.83
5
2
3
1
3
0.06
0.03

ANFY1_MOUSE
Rabankyrin-5
20
128571
5.58
5
2
4
1
4
0.07
0.03

MAGD1_MOUSE
Melanoma-associated antigen D1
20
85617
7.01
5
1
4
1
4
0.1
0.05

YIF1A_MOUSE
Protein YIF1A
19
32114
9.11
1
1
1
1
1
0.05
0.14

TR10B_MOUSE
Tumor necrosis factor receptor superfamily member 10B
19
42138
6.75
4
1
3
1
3
0.13
0.1

QCR8_MOUSE
Cytochrome b-c1 complex subunit 8
19
9762
10.26
1
1
1
1
1
0.28
0.51

ATP5J_MOUSE
ATP synthase-coupling factor 6, mitochondrial
18
12489
9.36
6
1
4
1
4
0.4
0.38

YAP1_MOUSE
Transcriptional coactivator YAP1
18
52351
4.96
1
1
1
1
1
0.05
0.08

PARP9_MOUSE
Poly [ADP-ribose] polymerase 9
17
96597
6.68
3
1
3
1
3
0.09
0.04

MTCH2_MOUSE
Mitochondrial carrier homolog 2
17
33477
8.59
1
1
1
1
1
0.07
0.13

NXN_MOUSE
Nucleoredoxin
17
48314
4.84
1
1
1
1
1
0.06
0.09

aProtein score is calculated from the score of the peptide attributed to the protein. bpI is (predicted) isoelectric point. cNumber of matches is spectrum number matched to protein #1. dNumber of significant matches is spectrum number that matches protein and exceeds the identification criteria. eNumber of sequences is number of peptides matched to protein #2. fNumber of significant sequences is number of peptides exceeding the identification criteria matched to proteins. gNumber of unique sequences is a unique #3 number of peptides matched to proteins. hSequence coverage is the ratio of the total number of matched peptide residues to the total length of the protein. iExponentially modified protein abundance index (http://www.matrixscience.com/help/quant_empai_help.html). #1When multiple spectra are matched to the same peptide, the way of counting into one is called "peptide number". #2When multiple spectra are matched to the same peptide, the method of counting is called "spectrum number". #3"Unique" is a peptide that is not matched to other proteins and has been assigned only to the relevant protein.

Table 2: Identification of endogenous proteins contained in mMSC-AT_P3 (cells passaged 3 times).

UniProt/Swiss-Prot ID
Description
Protein scorea
Protein mass (kDa)
pIb
Num. of matchesc
Num. of significant matchesd
Num. of sequencese
Num. of significant sequencesf
Num. of unique sequencesg
Sequence coverageh
emPAIi

MYH9_MOUSE
Myosin-9
3652
226232
5.54
238
130
81
52
74
0.52
1.93

MYH10_MOUSE
Myosin-10
793
228855
5.43
66
31
25
13
18
0.19
0.32

SERPH_MOUSE
Serpin H1
3042
46504
8.88
217
141
22
21
22
0.59
7.57

G3P_MOUSE
Glyceraldehyde-3-phosphate dehydrogenase
3019
35787
8.44
240
131
15
12
9
0.67
8.1

S10AB_MOUSE
Protein S100-A11
2948
11075
5.28
127
109
5
4
3
0.66
37.69

CLH1_MOUSE
Clathrin heavy chain 1
2893
191435
5.48
163
110
62
45
62
0.57
1.92

ACTN1_MOUSE
Alpha-actinin-1
2445
103004
5.23
136
82
42
31
27
0.65
2.98

ACTN4_MOUSE
Alpha-actinin-4
1377
104911
5.25
111
60
36
24
21
0.56
1.82

KPYM_MOUSE
Pyruvate kinase PKM
2269
57808
7.18
136
93
33
26
14
0.69
7.7

HS90A_MOUSE
Heat shock protein HSP 90-alpha
1754
84735
4.93
181
93
28
22
21
0.52
2.79

ENPL_MOUSE
Endoplasmin
1610
92418
4.74
101
64
34
24
16
0.48
2.39

TRAP1_MOUSE
Heat shock protein 75 kDa, mitochondrial
123
80159
6.25
6
6
4
4
4
0.11
0.23

ENOA_MOUSE
Alpha-enolase
2147
47111
6.37
163
78
20
14
7
0.69
4.37

FLNA_MOUSE
Filamin-A
2029
281046
5.68
241
136
64
42
61
0.43
0.93

FLNB_MOUSE
Filamin-B
1355
277651
5.46
119
68
56
40
52
0.43
0.86

FLNC_MOUSE
Filamin-C
351
290937
5.63
66
26
36
16
31
0.24
0.3

GRP75_MOUSE
Stress-70 protein, mitochondrial
961
73416
5.81
123
47
16
11
16
0.36
0.98

UBA1_MOUSE
Ubiquitin-like modifier-activating enzyme 1
1729
117734
5.43
87
64
29
22
29
0.58
1.52

TLN1_MOUSE
Talin-1
1723
269653
5.84
122
71
43
30
32
0.35
0.64

FAS_MOUSE
Fatty acid synthase
1679
272257
6.13
109
68
54
36
54
0.42
0.77

EF2_MOUSE
Elongation factor 2
1674
95253
6.41
114
76
31
25
31
0.61
2.27

VIME_MOUSE
Vimentin
1667
53655
5.06
152
77
37
26
37
0.67
8.53

ASSY_MOUSE
Argininosuccinate synthase
1574
46555
8.36
96
68
22
15
18
0.66
6.84

ANXA2_MOUSE
Annexin A2
1565
38652
7.55
126
98
14
11
14
0.54
2.27

VDAC1_MOUSE
Voltage-dependent anion-selective channel protein 1
1559
32331
8.55
161
108
13
8
13
0.65
2.18

VDAC2_MOUSE
Voltage-dependent anion-selective channel protein 2
312
31713
7.44
76
23
8
6
8
0.42
1.19

DYHC1_MOUSE
Cytoplasmic dynein 1 heavy chain 1
1401
531710
6.03
112
64
65
36
65
0.26
0.34

CH60_MOUSE
60 kDa heat shock protein, mitochondrial
1376
60917
5.91
76
42
22
18
22
0.54
2.67

PDIA1_MOUSE
Protein disulfide-isomerase
1325
57023
4.77
92
45
19
15
19
0.41
1.99

PLEC_MOUSE
Plectin
1320
533861
5.74
113
55
74
36
74
0.26
0.33

TKT_MOUSE
Transketolase
1319
67588
7.23
83
61
22
20
22
0.62
2.66

TBB6_MOUSE
Tubulin beta-6 chain
846
50058
4.8
83
31
19
13
7
0.61
2.48

ANXA5_MOUSE
Annexin A5
1219
35730
4.83
83
50
17
14
15
0.67
6.21

CATB_MOUSE
Cathepsin B
1206
37256
5.57
37
31
7
5
7
0.45
1.44

GELS_MOUSE
Gelsolin
1190
85888
5.83
68
48
19
15
13
0.56
1.29

GELS_HORSE
Gelsolin
546
80777
5.58
33
24
9
6
3
0.28
0.51

IMB1_MOUSE
Importin subunit beta-1
1155
97122
4.68
71
53
29
22
29
0.61
2.2

FPPS_MOUSE
Farnesyl pyrophosphate synthase
1095
40556
5.49
44
31
14
11
14
0.68
2.43

PSMD2_MOUSE
26S proteasome non-ATPase regulatory subunit 2
1057
100139
5.06
51
39
19
15
19
0.44
0.95

TCPA_MOUSE
T-complex protein 1 subunit alpha
1055
60411
5.82
44
31
16
11
16
0.54
1.29

ESTD_MOUSE
S-Formylglutathione hydrolase
1044
31299
6.7
53
36
15
11
15
0.79
4.6

ATPA_MOUSE
ATP synthase subunit alpha, mitochondrial
1041
59716
9.22
59
42
16
14
4
0.49
2.06

IQGA1_MOUSE
Ras GTPase-activating-like protein IQGAP1
1034
188624
6.07
67
37
35
19
35
0.36
0.56

WDR1_MOUSE
WD repeat-containing protein 1
1014
66365
6.11
64
42
19
15
19
0.65
1.57

TCPE_MOUSE
T-complex protein 1 subunit epsilon
1002
59586
5.72
51
33
15
9
15
0.55
1.16

SPB6_MOUSE
Serpin B6
988
42571
5.53
46
35
13
11
13
0.56
2.92

ACLY_MOUSE
ATP-citrate synthase
961
119651
7.13
64
44
26
20
26
0.42
1.08

LRP1_MOUSE
Prolow-density lipoprotein receptor-related protein 1
939
504411
5.14
76
46
37
25
37
0.16
0.27

CAN2_MOUSE
Calpain-2 catalytic subunit
937
79822
4.86
55
37
18
15
17
0.53
1.31

ALDOA_MOUSE
Fructose-bisphosphate aldolase A
923
39331
8.31
75
49
15
13
15
0.62
3.89

SPTB2_MOUSE
Spectrin beta chain, nonerythrocytic 1
900
274052
5.4
74
42
33
21
33
0.24
0.38

LDHA_MOUSE
L-Lactate dehydrogenase A chain
888
36475
7.62
64
43
17
12
13
0.68
3.92

LDHB_MOUSE
L-Lactate dehydrogenase B chain
144
36549
5.7
9
6
3
3
3
0.19
0.41

1433B_MOUSE
14-3-3 protein beta/alpha
483
28069
4.77
30
19
8
5
4
0.5
1.81

TCPZ_MOUSE
T-complex protein 1 subunit zeta
854
57968
6.63
51
37
13
10
13
0.41
1.05

COF1_MOUSE
Cofilin-1
795
18548
8.22
57
34
12
9
11
0.68
6.37

COF2_MOUSE
Cofilin-2
363
18698
7.66
17
10
5
5
4
0.46
2.01

SYAC_MOUSE
Alanine–tRNA ligase, cytoplasmic
785
106841
5.45
46
33
19
13
19
0.35
0.66

PLST_MOUSE
Plastin-3
784
70697
5.42
56
35
21
15
21
0.54
1.42

ANXA1_MOUSE
Annexin A1
774
38710
6.97
49
30
11
9
11
0.46
1.92

THIO_MOUSE
Thioredoxin
767
11668
4.8
33
19
7
3
7
0.78
1.85

PRDX6_MOUSE
Peroxiredoxin-6
751
24855
5.71
40
28
11
8
11
0.61
2.78

SPTN1_MOUSE
Spectrin alpha chain, nonerythrocytic 1
749
284422
5.2
77
34
42
24
42
0.27
0.42

LEG1_MOUSE
Galectin-1
735
14856
5.32
56
36
11
9
11
0.82
26.15

TCPH_MOUSE
T-complex protein 1 subunit eta
734
59614
7.95
38
26
16
12
16
0.5
1.48

HNRPF_MOUSE
Heterogeneous nuclear ribonucleoprotein F
710
45701
5.31
33
25
9
7
3
0.46
1.27

EF1G_MOUSE
Elongation factor 1-gamma
689
50029
6.31
44
28
15
13
15
0.57
1.95

PDIA3_MOUSE
Protein disulfide-isomerase A3
682
56643
5.88
64
37
23
16
14
0.54
2.5

TENA_MOUSE
Tenascin
679
231659
4.77
33
23
17
11
17
0.16
0.22

ATPB_MOUSE
ATP synthase subunit beta, mitochondrial
676
56265
5.19
69
33
23
15
7
0.74
2.27

RCN2_MOUSE
Reticulocalbin-2
663
37248
4.28
23
20
9
8
9
0.46
1.44

TCPB_MOUSE
T-complex protein 1 subunit beta
654
57441
5.97
32
19
17
12
17
0.49
1.39

LYAG_MOUSE
Lysosomal alpha-glucosidase
630
106180
5.53
45
34
16
13
16
0.34
0.81

CKAP4_MOUSE
Cytoskeleton-associated protein 4
626
63654
5.46
41
23
14
7
14
0.38
0.58

DPYL2_MOUSE
Dihydropyrimidinase-related protein 2
626
62239
5.95
47
26
24
13
21
0.63
1.39

DPYL3_MOUSE
Dihydropyrimidinase-related protein 3
602
61897
6.04
26
19
15
8
12
0.57
0.96

ESYT1_MOUSE
Extended synaptotagmin-1
621
121478
5.63
25
21
9
7
9
0.19
0.27

NEDD4_MOUSE
E3 ubiquitin-protein ligase NEDD4
611
102642
5.12
40
26
17
13
17
0.31
0.77

SYVC_MOUSE
Valine–tRNA ligase
604
140127
7.9
37
26
14
9
14
0.24
0.35

GSTO1_MOUSE
Glutathione S-transferase omega-1
600
27480
6.92
50
30
13
7
13
0.65
2.87

SEPT2_MOUSE
Septin-2
599
41499
6.1
24
19
9
8
8
0.38
1.46

6PGD_MOUSE
6-Phosphogluconate dehydrogenase, decarboxylating
599
53213
6.81
50
32
18
12
18
0.63
2

RPN1_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 1
597
68486
6.02
35
22
15
11
15
0.4
0.96

NUCL_MOUSE
Nucleolin
588
76677
4.69
37
22
15
9
15
0.27
0.63

GDIB_MOUSE
Rab GDP dissociation inhibitor beta
583
50505
5.93
40
26
13
10
11
0.45
1.48

TPM4_MOUSE
Tropomyosin alpha-4 chain
581
28450
4.65
51
29
10
9
10
0.44
3.3

PPCE_MOUSE
Prolyl endopeptidase
572
80700
5.44
30
21
12
10
12
0.29
0.68

NCPR_MOUSE
NADPH–cytochrome P450 reductase
570
76995
5.34
31
19
13
8
13
0.34
0.54

CISY_MOUSE
Citrate synthase, mitochondrial
563
51703
8.72
28
24
12
11
12
0.44
2.09

DDX3X_MOUSE
ATP-dependent RNA helicase DDX3X
555
73056
6.73
28
21
12
8
12
0.32
0.58

P5CS_MOUSE
Delta-1-pyrroline-5-carboxylate synthase
553
87212
7.18
26
18
10
5
10
0.2
0.27

MBB1A_MOUSE
Myb-binding protein 1A
547
151942
9.08
35
21
17
10
17
0.23
0.32

EF1B_MOUSE
Elongation factor 1-beta
546
24678
4.53
29
24
9
9
9
0.57
3.53

UGGG1_MOUSE
UDP-glucose:glycoprotein glucosyltransferase 1
545
176323
5.4
49
29
23
14
23
0.29
0.46

RPN2_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit 2
542
69020
5.54
27
19
12
11
12
0.37
0.94

HS105_MOUSE
Heat shock protein 105 kDa
541
96346
5.39
27
17
16
11
15
0.29
0.61

HSP74_MOUSE
Heat shock 70 kDa protein 4
440
94073
5.15
26
20
17
16
2
0.3
1.04

PROF1_MOUSE
Profilin-1
536
14948
8.46
79
30
8
7
8
0.61
19.18

GANAB_MOUSE
Neutral alpha-glucosidase AB
523
106844
5.67
49
27
20
15
20
0.46
0.8

THIC_MOUSE
Acetyl-CoA acetyltransferase, cytosolic
523
41271
7.16
30
20
8
6
8
0.5
0.83

ANXA6_MOUSE
Annexin A6
518
75837
5.34
39
20
19
10
19
0.4
0.73

P4HA1_MOUSE
Prolyl 4-hydroxylase subunit alpha-1
510
60872
5.62
32
26
13
10
13
0.44
1.13

NDKB_MOUSE
Nucleoside diphosphate kinase B
508
17352
6.97
31
19
7
4
4
0.63
2.27

KAD1_MOUSE
Adenylate kinase isoenzyme 1
499
21526
5.67
26
19
8
5
8
0.57
1.61

SAP_MOUSE
Prosaposin
497
61381
5.07
48
30
11
5
11
0.31
0.72

PGH1_MOUSE
Prostaglandin G/H synthase 1
491
68998
6.36
29
21
10
8
10
0.21
0.72

HMCS1_MOUSE
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
487
57532
5.65
31
22
15
13
15
0.49
1.76

CAP1_MOUSE
Adenylyl cyclase-associated protein 1
478
51532
7.16
39
22
11
8
11
0.36
0.91

MK01_MOUSE
Mitogen-activated protein kinase 1
474
41249
6.5
21
16
7
5
6
0.44
0.65

ARF4_MOUSE
ADP-ribosylation factor 4
470
20384
6.59
35
20
12
8
6
0.8
6.52

2AAA_MOUSE
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
470
65281
5
22
15
14
11
14
0.42
1.02

CPNS1_MOUSE
Calpain small subunit 1
469
28445
5.41
24
18
6
5
6
0.39
1.4

FSCN1_MOUSE
Fascin
463
54474
6.44
37
22
14
10
14
0.51
1.32

PDIA4_MOUSE
Protein disulfide-isomerase A4
461
71938
5.16
32
20
15
10
15
0.39
0.79

TSP1_MOUSE
Thrombospondin-1
460
129564
4.72
33
15
16
8
15
0.19
0.29

G6PI_MOUSE
Glucose-6-phosphate isomerase
459
62727
8.14
35
17
15
9
15
0.47
1.08

NP1L1_MOUSE
Nucleosome assembly protein 1-like 1
458
45317
4.36
30
19
11
9
10
0.47
1.51

ADT1_MOUSE
ADP/ATP translocase 1
413
32883
9.73
25
19
11
9
5
0.49
3.01

IPO5_MOUSE
Importin-5
449
123511
4.82
38
24
22
13
22
0.37
0.61

RINI_MOUSE
Ribonuclease inhibitor
440
49784
4.69
21
16
12
9
12
0.55
1.12

AT1A1_MOUSE
Sodium/potassium-transporting ATPase subunit alpha-1
436
112910
5.3
19
15
12
10
12
0.2
0.45

GFPT1_MOUSE
Glutamine–fructose-6-phosphate aminotransferase [isomerizing] 1
433
78489
6.39
19
14
11
7
11
0.27
0.45

PSA_MOUSE
Puromycin-sensitive aminopeptidase
432
103260
5.61
19
12
7
3
7
0.17
0.13

PDIA6_MOUSE
Protein disulfide-isomerase A6
424
48070
5
36
26
14
11
14
0.48
1.59

DEST_MOUSE
Destrin
421
18509
8.14
26
14
9
7
9
0.54
4.9

MYOF_MOUSE
Myoferlin
421
233177
5.83
29
19
19
13
19
0.15
0.31

ALDH2_MOUSE
Aldehyde dehydrogenase, mitochondrial
419
56502
7.53
28
16
10
7
10
0.4
0.8

HNRPU_MOUSE
Heterogeneous nuclear ribonucleoprotein U
417
87863
5.92
32
20
13
9
13
0.27
0.53

ANXA4_MOUSE
Annexin A4
415
35893
5.43
14
10
8
6
8
0.36
1

PDC6I_MOUSE
Programmed cell death 6-interacting protein
414
95964
6.15
25
17
14
8
14
0.28
0.48

MARCS_MOUSE
Myristoylated alanine-rich C-kinase substrate
413
29644
4.34
65
43
2
1
2
0.15
0.15

CALU_MOUSE
Calumenin
308
37041
4.49
29
16
9
8
3
0.44
1.74

VIGLN_MOUSE
Vigilin
410
141655
6.43
32
18
19
10
19
0.24
0.34

FBLN2_MOUSE
Fibulin-2
409
131746
4.58
20
15
12
9
12
0.18
0.33

OAT_MOUSE
Ornithine aminotransferase, mitochondrial
408
48324
6.19
18
12
9
6
9
0.37
0.68

TPP1_MOUSE
Tripeptidyl-peptidase 1
404
61304
6.1
9
8
2
2
2
0.1
0.15

RL9_MOUSE
60S ribosomal protein L9
398
21868
9.96
19
15
7
5
7
0.49
2.1

FLII_MOUSE
Protein flightless-1 homolog
397
144712
5.75
27
15
15
8
15
0.28
0.3

UGDH_MOUSE
UDP-glucose 6-dehydrogenase
397
54797
7.49
35
21
19
13
19
0.6
1.69

ECHA_MOUSE
Trifunctional enzyme subunit alpha, mitochondrial
396
82617
9.24
19
13
9
6
9
0.25
0.35

PUR2_MOUSE
Trifunctional purine biosynthetic protein adenosine-3
395
107436
6.25
24
14
10
5
10
0.22
0.31

PPIA_MOUSE
Peptidyl-prolyl cis-trans isomerase A
393
17960
7.74
31
21
9
8
9
0.65
8.83

6PGL_MOUSE
6-Phosphogluconolactonase
389
27237
5.55
11
8
5
4
5
0.39
0.84

CAND1_MOUSE
Cullin-associated NEDD8-dissociated protein 1
385
136245
5.52
46
27
16
10
16
0.3
0.4

GARS_MOUSE
Glycine–tRNA ligase
385
81826
6.24
29
17
15
10
15
0.42
0.67

SND1_MOUSE
Staphylococcal nuclease domain-containing protein 1
381
102025
7.08
39
20
20
13
20
0.4
0.78

ESYT2_MOUSE
Extended synaptotagmin-2
380
94081
7.63
22
14
9
6
9
0.17
0.31

IDHC_MOUSE
Isocitrate dehydrogenase [NADP] cytoplasmic
374
46644
6.73
30
16
17
9
16
0.54
1.23

COPB_MOUSE
Coatomer subunit beta
371
106998
5.69
35
19
16
12
16
0.31
0.6

CNPY2_MOUSE
Protein canopy homolog 2
371
20754
4.95
5
5
2
2
2
0.19
0.49

MYADM_MOUSE
Myeloid-associated differentiation marker
371
35261
8.69
32
7
3
2
3
0.14
0.27

SYIC_MOUSE
Isoleucine–tRNA ligase, cytoplasmic
368
144179
6.14
33
17
13
8
13
0.19
0.26

DHE3_MOUSE
Glutamate dehydrogenase 1, mitochondrial
366
61298
8.05
26
14
12
8
12
0.28
0.85

CLIC1_MOUSE
Chloride intracellular channel protein 1
363
26996
5.09
29
19
10
8
10
0.58
2.98

RCN3_MOUSE
Reticulocalbin-3
362
37978
4.74
13
7
4
3
4
0.31
0.39

FINC_MOUSE
Fibronectin
361
272368
5.39
31
15
14
8
14
0.11
0.13

ADK_MOUSE
Adenosine kinase
360
40123
5.84
18
15
7
6
5
0.4
0.86

DHB4_MOUSE
Peroxisomal multifunctional enzyme type 2
359
79432
8.76
12
8
5
2
4
0.11
0.11

CALX_MOUSE
Calnexin
357
67236
4.5
32
19
14
10
14
0.38
0.86

RLA0_MOUSE
60S acidic ribosomal protein P0
355
34195
5.91
26
19
11
7
11
0.51
1.64

PYRG2_MOUSE
CTP synthase 2
190
65473
6.05
12
7
7
3
6
0.27
0.21

CATZ_MOUSE
Cathepsin Z
353
33974
6.13
16
11
3
1
3
0.23
0.28

GNAI2_MOUSE
Guanine nucleotide-binding protein G(i) subunit alpha-2
352
40463
5.28
17
11
9
6
9
0.36
0.85

CH10_MOUSE
10 kDa heat shock protein, mitochondrial
352
10956
7.93
30
18
5
2
5
0.39
1.09

VATB2_MOUSE
V-type proton ATPase subunit B, brain isoform
350
56515
5.57
20
12
10
7
10
0.41
0.68

MDHM_MOUSE
Malate dehydrogenase, mitochondrial
346
35589
8.93
37
17
10
8
10
0.43
1.54

MYL9_MOUSE
Myosin regulatory light polypeptide 9
192
19841
4.8
15
7
7
5
4
0.62
1.82

ADHX_MOUSE
Alcohol dehydrogenase class-3
341
39522
6.97
11
9
6
5
6
0.4
0.69

APT_MOUSE
Adenine phosphoribosyltransferase
338
19712
6.31
20
10
7
5
7
0.56
1.84

IPO4_MOUSE
Importin-4
338
119198
4.92
24
17
12
8
12
0.21
0.32

AATM_MOUSE
Aspartate aminotransferase, mitochondrial
336
47381
9.13
26
14
11
6
11
0.41
0.69

SC31A_MOUSE
Protein transport protein Sec31A
334
133486
6.3
24
18
13
10
13
0.21
0.37

MAOX_MOUSE
NADP-dependent malic enzyme
329
63913
7.16
35
18
13
10
13
0.47
0.92

NDKA_MOUSE
Nucleoside diphosphate kinase A
324
17197
6.84
23
16
5
2
2
0.47
1.05

TAGL2_MOUSE
Transgelin-2
323
22381
8.39
18
11
7
6
7
0.49
2.63

PPAC_MOUSE
Low molecular weight phosphotyrosine protein phosphatase
323
18180
6.3
9
7
5
3
5
0.44
0.97

P4HA2_MOUSE
Prolyl 4-hydroxylase subunit alpha-2
322
60964
5.55
26
19
9
8
9
0.27
0.73

IF4G1_MOUSE
Eukaryotic translation initiation factor 4 gamma 1
322
175967
5.3
24
16
11
9
11
0.11
0.27

MRC2_MOUSE
C-type mannose receptor 2
321
166968
5.65
32
16
17
9
17
0.21
0.29

DCTN1_MOUSE
Dynactin subunit 1
319
141588
5.66
14
10
6
3
6
0.1
0.13

DPYL1_MOUSE
Dihydropyrimidinase-related protein 1
317
62129
6.63
9
5
6
2
3
0.17
0.14

MVD1_MOUSE
Diphosphomevalonate decarboxylase
315
44044
5.89
11
8
6
5
6
0.34
0.6

PUR9_MOUSE
Bifunctional purine biosynthesis protein PURH
315
64177
6.3
19
11
11
7
8
0.31
0.58

SNX9_MOUSE
Sorting nexin-9
313
66504
5.35
16
12
8
6
8
0.26
0.46

AR6P1_MOUSE
ADP-ribosylation factor-like protein 6-interacting protein 1
312
23421
9.38
6
6
1
1
1
0.14
0.42

XPO2_MOUSE
Exportin-2
312
110384
5.52
20
10
12
6
12
0.26
0.26

ANXA3_MOUSE
Annexin A3
312
36362
5.5
17
10
6
4
6
0.34
0.58

OST48_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase 48 kDa subunit
310
48997
5.52
21
15
9
8
9
0.41
1.34

TCPD_MOUSE
T-complex protein 1 subunit delta
310
58030
8.24
15
9
9
6
9
0.29
0.54

PLOD3_MOUSE
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
309
84869
5.81
29
18
17
10
17
0.41
0.64

RL5_MOUSE
60S ribosomal protein L5
308
34379
9.78
14
8
5
4
5
0.33
0.83

CATD_MOUSE
Cathepsin D
308
44925
6.71
39
18
10
8
10
0.58
2.04

SC22B_MOUSE
Vesicle-trafficking protein SEC22b
307
24725
8.67
18
12
7
4
7
0.6
1.3

PLOD1_MOUSE
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
306
83542
6.08
17
10
10
6
10
0.24
0.42

TCTP_MOUSE
Translationally-controlled tumor protein
306
19450
4.76
28
14
6
4
6
0.48
1.89

TCPG_MOUSE
T-complex protein 1 subunit gamma
304
60591
6.28
17
12
11
8
11
0.37
0.86

SC23A_MOUSE
Protein transport protein Sec23A
303
86106
6.64
10
7
6
3
6
0.16
0.16

SAHH_MOUSE
Adenosylhomocysteinase
302
47657
6.08
28
15
11
8
11
0.42
1.01

TCPQ_MOUSE
T-complex protein 1 subunit theta
298
59518
5.44
17
8
14
6
14
0.39
0.52

PSMD1_MOUSE
26S proteasome non-ATPase regulatory subunit 1
298
105663
5.25
37
15
15
8
15
0.32
0.37

COCA1_MOUSE
Collagen alpha-1(XII) chain
296
340004
5.47
24
7
14
6
14
0.09
0.08

GCN1_MOUSE
eIF-2-alpha kinase activator GCN1
295
292834
7.14
22
7
15
4
15
0.1
0.06

USO1_MOUSE
General vesicular transport factor p115
295
106917
4.85
20
15
10
5
10
0.22
0.22

UAP1L_MOUSE
UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
295
56578
5.27
20
15
7
6
6
0.21
0.56

UAP1_MOUSE
UDP-N-acetylhexosamine pyrophosphorylase
93
58572
6.04
10
4
5
2
4
0.12
0.15

PTBP1_MOUSE
Polypyrimidine tract-binding protein 1
289
56443
8.47
19
11
9
8
9
0.39
0.81

EIF3A_MOUSE
Eukaryotic translation initiation factor 3 subunit A
288
161838
6.38
18
11
10
5
10
0.12
0.14

GSTP1_MOUSE
Glutathione S-transferase P 1
286
23594
7.68
31
12
8
5
8
0.74
2.4

SERA_MOUSE
D-3-Phosphoglycerate dehydrogenase
279
56549
6.12
15
10
9
7
9
0.32
0.8

GDIR1_MOUSE
Rho GDP-dissociation inhibitor 1
279
23393
5.12
29
18
9
6
9
0.42
1.88

VINC_MOUSE
Vinculin
278
116644
5.77
27
14
15
10
15
0.26
0.43

PNPH_MOUSE
Purine nucleoside phosphorylase
277
32256
5.78
12
8
5
4
5
0.37
0.67

PSMD7_MOUSE
26S proteasome non-ATPase regulatory subunit 7
275
36517
6.29
17
12
8
6
8
0.54
0.98

LRC59_MOUSE
Leucine-rich repeat-containing protein 59
274
34856
9.57
14
9
6
2
6
0.32
0.27

UBP14_MOUSE
Ubiquitin carboxyl-terminal hydrolase 14
273
55966
5.15
14
11
6
4
6
0.25
0.35

CNN3_MOUSE
Calponin-3
272
36406
5.46
20
12
8
6
8
0.45
1.22

SDHA_MOUSE
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
270
72539
7.06
16
11
7
4
7
0.27
0.26

VAT1_MOUSE
Synaptic vesicle membrane protein VAT-1 homolog
269
43069
5.95
29
12
10
7
10
0.38
0.97

RLA2_MOUSE
60S acidic ribosomal protein P2
267
11644
4.42
17
10
5
3
5
0.7
1.85

ARLY_MOUSE
Argininosuccinate lyase
264
51707
6.48
10
8
5
3
5
0.22
0.38

DDX1_MOUSE
ATP-dependent RNA helicase DDX1
263
82448
6.8
18
9
12
6
12
0.29
0.36

PYR1_MOUSE
CAD protein
262
243084
6
22
8
14
6
14
0.13
0.11

AATC_MOUSE
Aspartate aminotransferase, cytoplasmic
260
46219
6.68
16
7
7
4
7
0.3
0.43

STIP1_MOUSE
Stress-induced-phosphoprotein 1
259
62542
6.4
18
8
9
6
9
0.31
0.49

ZYX_MOUSE
Zyxin
257
60507
5.99
15
11
5
3
5
0.17
0.32

RL3_MOUSE
60S ribosomal protein L3
257
46081
10.22
18
10
7
5
7
0.25
0.57

CO1A1_MOUSE
Collagen alpha-1(I) chain
253
137948
5.65
19
14
9
6
8
0.12
0.24

PCOC1_MOUSE
Procollagen C-endopeptidase enhancer 1
253
50136
8.73
11
8
7
4
7
0.33
0.51

RL6_MOUSE
60S ribosomal protein L6
250
33489
10.69
13
9
8
5
8
0.25
0.86

PP1A_MOUSE
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
249
37516
5.94
19
13
8
7
4
0.38
1.17

FUMH_MOUSE
Fumarate hydratase, mitochondrial
246
54322
9.12
20
11
8
5
8
0.35
0.59

PCBP2_MOUSE
Poly(rC)-binding protein 2
154
38197
6.33
25
11
7
4
5
0.33
0.55

LKHA4_MOUSE
Leukotriene A-4 hydrolase
246
69007
5.98
15
10
9
4
9
0.22
0.27

TOM40_MOUSE
Mitochondrial import receptor subunit TOM40 homolog
244
37871
7.64
18
10
9
6
9
0.48
0.93

SH3L3_MOUSE
SH3 domain-binding glutamic acid-rich-like protein 3
243
10470
5.02
15
10
3
1
3
0.65
1.17

SYNC_MOUSE
Asparagine–tRNA ligase, cytoplasmic
242
64238
5.62
22
12
15
6
15
0.38
0.48

PUR6_MOUSE
Multifunctional protein ADE2
242
46976
6.94
23
10
10
5
10
0.44
0.7

AL7A1_MOUSE
Alpha-aminoadipic semialdehyde dehydrogenase
242
58824
7.16
13
9
6
5
6
0.27
0.43

CP51A_MOUSE
Lanosterol 14-alpha demethylase
242
56739
8.6
16
8
9
3
9
0.34
0.25

SYSC_MOUSE
Serine–tRNA ligase, cytoplasmic
241
58352
5.95
19
9
10
4
10
0.35
0.33

NDUS1_MOUSE
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
239
79726
5.51
15
10
9
4
9
0.22
0.3

EIF3H_MOUSE
Eukaryotic translation initiation factor 3 subunit H
238
39807
6.2
22
14
11
7
11
0.5
1.3

PSB6_MOUSE
Proteasome subunit beta type-6
237
25362
4.97
7
7
4
4
4
0.47
0.92

PSA6_MOUSE
Proteasome subunit alpha type-6
235
27355
6.34
9
8
3
3
3
0.29
0.58

AMPL_MOUSE
Cytosol aminopeptidase
234
56106
7.62
17
9
11
6
11
0.34
0.68

TXND5_MOUSE
Thioredoxin domain-containing protein 5
232
46386
5.51
13
7
7
4
7
0.29
0.43

TAGL_MOUSE
Transgelin
231
22561
8.85
19
13
8
6
8
0.49
2

AIMP2_MOUSE
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
229
35355
7.7
15
9
6
3
6
0.42
0.42

RET1_MOUSE
Retinol-binding protein 1
229
15836
5.1
9
6
4
3
4
0.44
1.17

IPYR_MOUSE
Inorganic pyrophosphatase
229
32646
5.37
14
7
7
3
7
0.31
0.46

GSTM2_MOUSE
Glutathione S-transferase Mu 2
228
25700
6.9
14
9
7
6
6
0.39
1.62

GSTM1_MOUSE
Glutathione S-transferase Mu 1
197
25953
7.71
14
8
5
4
4
0.33
0.89

SYRC_MOUSE
Arginine–tRNA ligase, cytoplasmic
228
75625
7.48
23
13
12
7
12
0.24
0.47

WDR61_MOUSE
WD repeat-containing protein 61
228
33752
5.1
6
4
3
2
3
0.18
0.28

IMA4_MOUSE
Importin subunit alpha-4
178
57737
4.8
10
7
6
4
4
0.32
0.34

RL7_MOUSE
60S ribosomal protein L7
227
31400
10.89
13
7
6
3
5
0.24
0.49

PSME2_MOUSE
Proteasome activator complex subunit 2
227
27040
5.54
14
7
5
4
5
0.34
0.84

SCRB2_MOUSE
Lysosome membrane protein 2
225
54009
4.99
13
8
6
4
6
0.2
0.36

AT2A2_MOUSE
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
224
114784
5.23
26
12
13
7
13
0.24
0.29

SODM_MOUSE
Superoxide dismutase [Mn], mitochondrial
222
24588
8.8
14
8
5
3
5
0.5
0.96

SYLC_MOUSE
Leucine–tRNA ligase, cytoplasmic
222
134106
6.64
22
7
13
4
13
0.19
0.13

PTGIS_MOUSE
Prostacyclin synthase
222
57011
6.26
28
17
13
9
6
0.52
0.93

PYGB_MOUSE
Glycogen phosphorylase, brain form
219
96668
6.28
16
10
9
6
9
0.16
0.3

MPCP_MOUSE
Phosphate carrier protein, mitochondrial
218
39606
9.36
15
11
8
5
8
0.32
0.88

LAMP1_MOUSE
Lysosome-associated membrane glycoprotein 1
217
43837
8.66
8
7
4
3
4
0.16
0.46

COPA_MOUSE
Coatomer subunit alpha
217
138344
7.69
23
11
16
9
16
0.23
0.31

KINH_MOUSE
Kinesin-1 heavy chain
216
109484
6.06
13
6
10
4
10
0.19
0.17

LG3BP_MOUSE
Galectin-3-binding protein
216
64450
5
12
5
8
5
8
0.29
0.38

PSB4_MOUSE
Proteasome subunit beta type-4
215
29097
5.47
5
3
3
2
3
0.23
0.33

IDI1_MOUSE
Isopentenyl-diphosphate delta-isomerase 1
215
26272
5.79
19
12
8
7
8
0.54
2.01

CNN2_MOUSE
Calponin-2
215
33134
7.53
17
9
9
4
9
0.59
1.12

NAA15_MOUSE
N-Alpha-acetyltransferase 15, NatA auxiliary subunit
212
100897
7.68
19
9
9
5
9
0.18
0.23

IF2P_MOUSE
Eukaryotic translation initiation factor 5B
212
137532
5.47
16
9
7
4
7
0.14
0.16

LGMN_MOUSE
Legumain
211
49341
5.92
10
9
3
3
3
0.17
0.4

DJC10_MOUSE
DnaJ homolog subfamily C member 10
210
90525
6.53
15
10
6
3
6
0.13
0.2

PFKAL_MOUSE
ATP-dependent 6-phosphofructokinase, liver type
210
85305
6.74
11
8
6
6
6
0.12
0.34

UGPA_MOUSE
UTP–glucose-1-phosphate uridylyltransferase
210
56944
7.18
8
6
6
5
6
0.26
0.44

RTN4_MOUSE
Reticulon-4
210
126535
4.47
11
9
6
4
6
0.12
0.14

CD34_MOUSE
Hematopoietic progenitor cell antigen CD34
208
40957
5.2
3
3
1
1
1
0.05
0.11

TPP2_MOUSE
Tripeptidyl-peptidase 2
208
139790
6.13
15
8
9
4
9
0.16
0.13

PCNA_MOUSE
Proliferating cell nuclear antigen
208
28766
4.66
15
8
8
6
8
0.63
1.37

TSPO_MOUSE
Translocator protein
205
18829
9.52
12
8
4
2
4
0.46
0.92

SNAA_MOUSE
Alpha-soluble NSF attachment protein
202
33168
5.3
13
7
7
4
7
0.43
0.65

PDXD1_MOUSE
Pyridoxal-dependent decarboxylase domain-containing protein 1
202
87281
5.31
6
4
4
3
4
0.1
0.15

PRDX1_MOUSE
Peroxiredoxin-1
202
22162
8.26
43
18
16
7
14
0.69
2.67

DHX9_MOUSE
ATP-dependent RNA helicase A
201
149381
6.39
19
12
11
6
11
0.16
0.18

MIC60_MOUSE
MICOS complex subunit Mic60
200
83848
6.18
14
8
4
3
4
0.1
0.16

AACS_MOUSE
Acetoacetyl-CoA synthetase
199
75152
6.25
24
9
11
7
11
0.36
0.56

SERC_MOUSE
Phosphoserine aminotransferase
199
40447
8.15
23
12
11
5
11
0.52
0.85

HYOU1_MOUSE
Hypoxia-upregulated protein 1
198
111112
5.12
14
7
9
4
9
0.18
0.21

INF2_MOUSE
Inverted formin-2
198
138474
5.09
18
8
10
4
10
0.14
0.13

PSMD6_MOUSE
26S proteasome non-ATPase regulatory subunit 6
197
45507
5.38
4
4
2
2
2
0.1
0.2

AL9A1_MOUSE
4-Trimethylaminobutyraldehyde dehydrogenase
196
53480
6.63
9
6
3
2
3
0.17
0.26

RN213_MOUSE
E3 ubiquitin-protein ligase RNF213
196
584411
6.35
23
8
21
7
21
0.07
0.05

CX7A2_MOUSE
Cytochrome c oxidase subunit 7A2, mitochondrial
196
9285
10.28
7
6
3
2
3
0.59
1.37

PSB5_MOUSE
Proteasome subunit beta type-5
196
28514
6.52
10
8
5
4
5
0.32
0.79

TMX3_MOUSE
Protein disulfide-isomerase TMX3
196
51815
5.02
4
4
2
2
2
0.11
0.17

DLDH_MOUSE
Dihydrolipoyl dehydrogenase, mitochondrial
195
54238
7.99
16
12
5
4
5
0.21
0.47

AEBP1_MOUSE
Adipocyte enhancer-binding protein 1
194
128284
5.02
4
3
2
1
2
0.02
0.03

MP2K1_MOUSE
Dual specificity mitogen-activated protein kinase 1
194
43446
6.24
9
5
6
2
5
0.32
0.21

MP2K2_MOUSE
Dual specificity mitogen-activated protein kinase 2
191
44374
6.58
5
5
2
2
1
0.12
0.21

STRAP_MOUSE
Serine-threonine kinase receptor-associated protein
193
38418
4.99
12
10
6
5
6
0.35
0.72

XPO1_MOUSE
Exportin-1
192
123013
5.72
18
10
12
8
12
0.2
0.31

EIF3I_MOUSE
Eukaryotic translation initiation factor 3 subunit I
191
36438
5.38
13
8
6
3
6
0.36
0.41

CPNE1_MOUSE
Copine-1
190
58849
5.4
11
7
7
4
7
0.3
0.33

EIF3K_MOUSE
Eukaryotic translation initiation factor 3 subunit K
189
25070
4.81
7
4
4
3
4
0.33
0.64

MIF_MOUSE
Macrophage migration inhibitory factor
189
12496
6.79
13
7
5
3
5
0.63
2.67

CYFP1_MOUSE
Cytoplasmic FMR1-interacting protein 1
189
145148
6.46
14
6
10
3
10
0.16
0.09

MYO1C_MOUSE
Unconventional myosin-Ic
188
121868
9.41
30
7
18
6
18
0.29
0.23

JAK1_MOUSE
Tyrosine-protein kinase JAK1
188
133282
7.63
11
5
6
1
6
0.1
0.03

ARPC2_MOUSE
Actin-related protein 2/3 complex subunit 2
188
34336
6.84
14
10
7
4
7
0.41
0.62

CSAD_MOUSE
Cysteine sulfinic acid decarboxylase
187
55109
6.17
5
3
3
1
3
0.11
0.08

PA2G4_MOUSE
Proliferation-associated protein 2G4
185
43671
6.41
4
4
3
3
3
0.15
0.33

DJB11_MOUSE
DnaJ homolog subfamily B member 11
185
40530
5.92
13
7
5
3
5
0.2
0.36

NSDHL_MOUSE
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating
184
40660
7.71
20
8
7
6
7
0.39
0.85

P3H1_MOUSE
Prolyl 3-hydroxylase 1
184
83598
5.03
21
11
7
3
7
0.2
0.16

S10AA_MOUSE
Protein S100-A10
184
11179
6.27
5
5
2
2
2
0.44
1.06

DHB12_MOUSE
Very-long-chain 3-oxoacyl-CoA reductase
182
34719
9.55
15
10
7
5
7
0.45
0.82

SPRC_MOUSE
SPARC
182
34428
4.77
11
6
5
3
5
0.25
0.44

DHB7_MOUSE
3-Keto-steroid reductase
179
37293
6.25
5
5
4
4
4
0.21
0.56

MPRD_MOUSE
Cation-dependent mannose-6-phosphate receptor
179
31152
5.24
5
4
3
2
3
0.18
0.3

FKB10_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP10
179
64656
5.38
17
7
9
4
9
0.32
0.29

FRIL1_MOUSE
Ferritin light chain 1
178
20790
5.66
13
8
4
3
4
0.43
0.81

PGP_MOUSE
Glycerol-3-phosphate phosphatase
178
34519
5.21
3
3
1
1
1
0.06
0.13

IMPA1_MOUSE
Inositol monophosphatase 1
178
30416
5.08
7
6
3
2
3
0.12
0.31

SYCC_MOUSE
Cysteine–tRNA ligase, cytoplasmic
178
94800
6.32
12
5
7
5
7
0.18
0.25

FKBP4_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP4
177
51540
5.54
9
8
3
3
3
0.12
0.27

PPIB_MOUSE
Peptidyl-prolyl cis-trans isomerase B
177
23699
9.56
10
5
6
2
6
0.33
0.42

NASP_MOUSE
Nuclear autoantigenic sperm protein
177
83903
4.35
10
10
4
4
4
0.14
0.22

MPRI_MOUSE
Cation-independent mannose-6-phosphate receptor
177
273639
5.47
14
6
12
4
12
0.1
0.06

NQO1_MOUSE
NAD(P)H dehydrogenase [quinone] 1
175
30940
8.74
19
7
5
4
5
0.49
0.71

GCSH_MOUSE
Glycine cleavage system H protein, mitochondrial
173
18625
4.78
5
5
1
1
1
0.22
0.55

ITB1_MOUSE
Integrin beta-1
173
88173
5.68
22
10
12
6
12
0.29
0.33

CO1A2_MOUSE
Collagen alpha-2(I) chain
173
129478
9.27
20
12
10
4
10
0.12
0.14

HNRPM_MOUSE
Heterogeneous nuclear ribonucleoprotein M
172
77597
8.8
18
6
11
4
11
0.24
0.24

GHITM_MOUSE
Growth hormone-inducible transmembrane protein
172
37250
9.82
5
3
2
1
2
0.09
0.25

TTL12_MOUSE
Tubulin–tyrosine ligase-like protein 12
172
73996
5.39
15
7
8
5
8
0.27
0.33

RAB1B_MOUSE
Ras-related protein Rab-1B
118
22173
5.55
14
5
7
5
2
0.53
1.53

ACO13_MOUSE
Acyl-coenzyme A thioesterase 13
171
15173
8.95
8
7
3
3
3
0.41
1.24

MMP14_MOUSE
Matrix metalloproteinase-14
171
65877
8.07
6
5
4
3
4
0.13
0.21

PSA7_MOUSE
Proteasome subunit alpha type-7
171
27838
8.59
11
8
6
4
6
0.38
0.81

LEG3_MOUSE
Galectin-3
170
27498
8.46
24
11
7
5
7
0.35
1.12

PMVK_MOUSE
Phosphomevalonate kinase
169
21902
5.7
2
2
1
1
1
0.1
0.21

TPIS_MOUSE
Triosephosphate isomerase
169
32171
5.56
17
7
8
4
8
0.39
0.67

SEPT9_MOUSE
Septin-9
168
65534
9.01
11
4
7
3
7
0.22
0.21

UBR4_MOUSE
E3 ubiquitin-protein ligase UBR4
167
571927
5.72
24
10
16
6
16
0.07
0.05

GPDM_MOUSE
Glycerol-3-phosphate dehydrogenase, mitochondrial
167
80902
6.17
27
10
16
8
16
0.35
0.51

GLCM_MOUSE
Glucosylceramidase
166
57585
7.64
28
11
9
6
9
0.39
0.66

LA_MOUSE
Lupus La protein homolog
166
47727
9.77
9
7
7
5
7
0.23
0.55

VCAM1_MOUSE
Vascular cell adhesion protein 1
166
81265
5.21
7
6
3
3
3
0.07
0.17

AP2A1_MOUSE
AP-2 complex subunit alpha-1
165
107596
6.63
18
6
10
5
7
0.19
0.21

HMOX2_MOUSE
Heme oxygenase 2
164
35716
5.61
5
2
3
1
3
0.23
0.12

ITAV_MOUSE
Integrin alpha-V
164
115287
5.41
15
9
11
7
11
0.16
0.29

ECI1_MOUSE
Enoyl-CoA delta isomerase 1, mitochondrial
163
32230
9.12
4
4
2
2
2
0.15
0.29

SYEP_MOUSE
Bifunctional glutamate/proline–tRNA ligase
162
169972
7.75
33
10
18
7
18
0.22
0.19

KAD2_MOUSE
Adenylate kinase 2, mitochondrial
162
26452
6.96
5
5
2
2
2
0.16
0.37

NOMO1_MOUSE
Nodal modulator 1
161
133336
5.75
19
9
11
4
11
0.19
0.13

C1TM_MOUSE
Monofunctional C1-tetrahydrofolate synthase, mitochondrial
161
105662
6.58
9
7
4
3
4
0.09
0.13

AKAP2_MOUSE
A-kinase anchor protein 2
160
98519
5.13
4
3
3
2
3
0.05
0.09

SFPQ_MOUSE
Splicing factor, proline- and glutamine-rich
160
75394
9.45
5
3
2
1
2
0.05
0.06

BACH_MOUSE
Cytosolic acyl coenzyme A thioester hydrolase
159
42510
8.9
15
7
9
5
9
0.37
0.63

GLRX1_MOUSE
Glutaredoxin-1
159
11863
8.67
7
6
2
1
2
0.47
0.98

DHC24_MOUSE
Delta(24)-sterol reductase
159
60073
8.42
16
8
6
4
6
0.23
0.32

NMT1_MOUSE
Glycylpeptide N-tetradecanoyltransferase 1
159
56852
8.04
6
5
3
2
3
0.15
0.25

PRDX3_MOUSE
Thioredoxin-dependent peroxide reductase, mitochondrial
158
28109
7.15
7
6
4
3
4
0.35
0.56

CAVN1_MOUSE
Caveolae-associated protein 1
157
43927
5.43
8
5
4
2
4
0.18
0.21

PALLD_MOUSE
Palladin
156
152037
5.87
11
8
7
5
7
0.1
0.15

NPC1_MOUSE
Niemann-Pick C1 protein
156
142791
5.44
4
3
2
1
2
0.04
0.03

SRPRB_MOUSE
Signal recognition particle receptor subunit beta
156
29561
9.34
4
3
3
2
3
0.16
0.32

PCYOX_MOUSE
Prenylcysteine oxidase
156
56459
6.44
10
4
7
3
7
0.27
0.34

TRBM_MOUSE
Thrombomodulin
155
61827
4.5
9
8
2
2
2
0.13
0.22

PSB2_MOUSE
Proteasome subunit beta type-2
154
22892
6.52
25
11
6
6
6
0.54
1.95

AB1IP_MOUSE
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
154
74272
5.23
13
5
5
2
5
0.14
0.12

AGM1_MOUSE
Phosphoacetylglucosamine mutase
154
59415
5.8
8
6
3
2
3
0.13
0.23

APEH_MOUSE
Acylamino-acid-releasing enzyme
153
81529
5.36
7
6
5
4
5
0.16
0.23

CATL1_MOUSE
Cathepsin L1
153
37523
6.37
12
10
6
4
6
0.44
0.56

ATOX1_MOUSE
Copper transport protein ATOX1
151
7334
6.04
8
7
2
1
2
0.53
0.72

ALD2_MOUSE
Aldose reductase-related protein 2
151
36098
5.97
11
8
7
5
7
0.36
0.78

PPIC_MOUSE
Peptidyl-prolyl cis-trans isomerase C
151
22780
6.96
7
6
4
3
4
0.46
1.07

NRDC_MOUSE
Nardilysin
150
132808
4.77
14
6
8
3
8
0.15
0.1

MD2L1_MOUSE
Mitotic spindle assembly checkpoint protein MAD2A
150
23583
5.17
6
3
2
1
2
0.17
0.19

BROX_MOUSE
BRO1 domain-containing protein BROX
149
46172
7.59
6
4
4
2
4
0.22
0.2

SYTC_MOUSE
Threonine–tRNA ligase, cytoplasmic
148
83303
7.03
21
9
13
5
13
0.25
0.29

DNJA1_MOUSE
DnaJ homolog subfamily A member 1
148
44839
6.65
14
9
6
4
6
0.31
0.59

NNRE_MOUSE
NAD(P)H-hydrate epimerase
147
30953
7.59
11
9
4
3
4
0.3
0.49

CPNE3_MOUSE
Copine-3
147
59547
5.52
6
5
3
3
3
0.1
0.23

PTGR1_MOUSE
Prostaglandin reductase 1
147
35537
8.09
9
5
4
2
4
0.26
0.42

C1QBP_MOUSE
Complement component 1 Q subcomponent-binding protein, mitochondrial
146
30994
4.82
18
8
6
5
6
0.45
0.95

ERG7_MOUSE
Lanosterol synthase
145
83088
5.96
13
5
9
3
9
0.23
0.22

PAPS1_MOUSE
Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1
144
70749
6.31
11
4
8
4
8
0.21
0.27

MTPN_MOUSE
Myotrophin
143
12853
5.27
11
7
6
3
6
0.62
1.59

VATA_MOUSE
V-type proton ATPase catalytic subunit A
143
68283
5.42
16
6
7
3
7
0.25
0.2

ATPG_MOUSE
ATP synthase subunit gamma, mitochondrial
143
32865
9.06
7
5
4
2
4
0.26
0.29

DDB1_MOUSE
DNA damage-binding protein 1
143
126772
5.14
20
10
11
5
11
0.21
0.18

RL4_MOUSE
60S ribosomal protein L4
143
47124
11.01
16
6
12
5
12
0.37
0.55

NDUB4_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
143
15072
9.89
4
4
1
1
1
0.16
0.31

CRTAP_MOUSE
Cartilage-associated protein
143
46140
5.46
12
7
5
4
5
0.2
0.43

TFR1_MOUSE
Transferrin receptor protein 1
143
85677
6.13
11
7
3
3
3
0.08
0.16

EI3JA_MOUSE
Eukaryotic translation initiation factor 3 subunit J-A
142
29326
4.69
5
3
2
2
2
0.1
0.33

ATLA3_MOUSE
Atlastin-3
142
60537
5.73
15
7
10
5
10
0.36
0.41

PUR4_MOUSE
Phosphoribosylformylglycinamidine synthase
142
144538
5.43
10
7
8
5
8
0.14
0.16

IPO9_MOUSE
Importin-9
142
115978
4.71
16
9
8
5
8
0.2
0.2

PSMD3_MOUSE
26S proteasome non-ATPase regulatory subunit 3
141
60680
8.48
10
8
6
5
6
0.14
0.41

AK1A1_MOUSE
Alcohol dehydrogenase [NADP(+)]
141
36564
6.9
5
3
4
2
4
0.27
0.26

DCTN3_MOUSE
Dynactin subunit 3
140
20965
5.84
4
3
3
2
3
0.31
0.8

SWP70_MOUSE
Switch-associated protein 70
138
68953
5.78
13
7
6
5
6
0.17
0.35

ATPO_MOUSE
ATP synthase subunit O, mitochondrial
137
23349
10
7
4
2
2
2
0.17
0.43

UN45A_MOUSE
Protein unc-45 homolog A
137
103382
6.01
9
3
7
2
7
0.13
0.08

SCOT1_MOUSE
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
137
55953
8.73
20
9
10
7
10
0.36
0.68

BCAT1_MOUSE
Branched-chain-amino-acid aminotransferase, cytosolic
137
42764
5.25
8
7
3
3
3
0.21
0.48

ASNS_MOUSE
Asparagine synthetase [glutamine-hydrolyzing]
137
64241
6.12
16
8
7
4
7
0.19
0.3

PPGB_MOUSE
Lysosomal protective protein
136
53809
5.56
7
4
3
2
3
0.1
0.17

PGBM_MOUSE
Basement membrane-specific heparan sulfate proteoglycan core protein
136
398039
5.88
25
6
13
2
13
0.07
0.02

CSN7A_MOUSE
COP9 signalosome complex subunit 7a
136
30206
7.68
14
7
6
3
6
0.51
0.51

HCD2_MOUSE
3-Hydroxyacyl-CoA dehydrogenase type-2
136
27402
8.53
6
3
4
2
4
0.2
0.35

BZW2_MOUSE
Basic leucine zipper and W2 domain-containing protein 2
135
48033
6.26
6
4
3
1
3
0.22
0.19

TOM70_MOUSE
Mitochondrial import receptor subunit TOM70
135
67547
7.46
10
7
6
4
4
0.24
0.28

XPP1_MOUSE
Xaa-Pro aminopeptidase 1
135
69547
5.33
14
7
7
4
4
0.18
0.27

NXP20_MOUSE
Protein Noxp20
135
60975
4.49
6
6
1
1
1
0.07
0.15

PAI1_MOUSE
Plasminogen activator inhibitor 1
134
45141
6.17
9
3
7
2
7
0.32
0.2

ROA0_MOUSE
Heterogeneous nuclear ribonucleoprotein A0
134
30512
9.35
9
3
4
2
4
0.24
0.31

GORS2_MOUSE
Golgi reassembly-stacking protein 2
134
47009
4.68
4
3
3
2
3
0.14
0.19

SMC2_MOUSE
Structural maintenance of chromosomes protein 2
131
134156
8.54
8
5
5
2
5
0.06
0.06

RAB21_MOUSE
Ras-related protein Rab-21
132
24091
8.11
7
5
5
4
5
0.21
0.99

SAC1_MOUSE
Phosphatidylinositide phosphatase SAC1
132
66901
6.85
8
3
5
3
5
0.16
0.21

HSPB1_MOUSE
Heat shock protein beta-1
131
23000
6.12
14
9
7
4
7
0.66
1.05

GLU2B_MOUSE
Glucosidase 2 subunit beta
131
58756
4.41
9
6
3
2
3
0.12
0.24

IMA1_MOUSE
Importin subunit alpha-1
130
57892
5.49
10
5
6
4
6
0.27
0.33

SEC13_MOUSE
Protein SEC13 homolog
130
35543
5.15
19
5
4
3
4
0.19
0.42

4F2_MOUSE
4F2 cell-surface antigen heavy chain
130
58300
5.62
5
5
2
2
2
0.1
0.15

CSN4_MOUSE
COP9 signalosome complex subunit 4
130
46256
5.57
9
4
6
2
6
0.25
0.2

ROAA_MOUSE
Heterogeneous nuclear ribonucleoprotein A/B
129
30812
7.68
11
9
6
6
6
0.2
1.24

ERF3A_MOUSE
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
129
68582
5.12
19
10
9
6
9
0.18
0.44

CUL4A_MOUSE
Cullin-4A
128
87697
8.53
4
2
3
2
1
0.07
0.1

CUL4B_MOUSE
Cullin-4B
102
110630
8.56
7
3
6
3
4
0.12
0.12

AHSA1_MOUSE
Activator of 90 kDa heat shock protein ATPase homolog 1
128
38093
5.41
6
3
4
2
4
0.23
0.24

PDLI1_MOUSE
PDZ and LIM domain protein 1
127
35752
6.38
9
5
5
4
5
0.25
0.59

ECHM_MOUSE
Enoyl-CoA hydratase, mitochondrial
127
31454
8.76
8
5
5
3
5
0.33
0.49

ITA5_MOUSE
Integrin alpha-5
126
114971
5.65
13
6
6
2
6
0.09
0.08

NDUBA_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
126
21010
8.19
6
4
4
3
4
0.31
0.8

RENBP_MOUSE
N-Acylglucosamine 2-epimerase
126
49739
5.69
8
5
5
3
5
0.21
0.29

NU155_MOUSE
Nuclear pore complex protein Nup155
125
155019
5.77
9
6
5
3
5
0.06
0.08

DDAH1_MOUSE
N(G),N(G)-Dimethylarginine dimethylaminohydrolase 1
125
31361
5.64
6
4
5
3
5
0.4
0.49

G6PE_MOUSE
GDH/6PGL endoplasmic bifunctional protein
124
88872
6.44
16
3
9
3
9
0.21
0.15

CO5A1_MOUSE
Collagen alpha-1(V) chain
124
183564
4.86
7
3
6
2
6
0.09
0.05

PLAP_MOUSE
Phospholipase A-2-activating protein
124
87166
5.77
6
2
5
1
5
0.15
0.05

PDLI5_MOUSE
PDZ and LIM domain protein 5
123
63259
8.61
15
6
7
3
7
0.21
0.22

NAGAB_MOUSE
Alpha-N-acetylgalactosaminidase
122
47204
6.02
7
5
6
4
6
0.23
0.42

PDIA5_MOUSE
Protein disulfide-isomerase A5
121
59229
7.25
5
5
4
4
4
0.19
0.33

PSMD5_MOUSE
26S proteasome non-ATPase regulatory subunit 5
121
55937
5.13
12
6
7
4
7
0.26
0.35

FRIH_MOUSE
Ferritin heavy chain
120
21053
5.53
9
6
5
3
5
0.48
0.8

OSTF1_MOUSE
Osteoclast-stimulating factor 1
119
23768
5.46
6
2
4
1
4
0.19
0.19

PFD5_MOUSE
Prefoldin subunit 5
119
17345
5.93
7
4
4
3
4
0.47
1.04

PCKGM_MOUSE
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
119
70482
6.92
16
7
10
7
10
0.26
0.51

SAE2_MOUSE
SUMO-activating enzyme subunit 2
119
70525
5.09
8
6
5
4
5
0.21
0.27

NSF_MOUSE
Vesicle-fusing ATPase
119
82561
6.52
7
3
7
3
7
0.17
0.16

THY1_MOUSE
Thy-1 membrane glycoprotein
118
18069
9.16
9
2
3
1
3
0.25
0.26

RRBP1_MOUSE
Ribosome-binding protein 1
117
172776
9.35
12
3
9
3
9
0.1
0.08

CYB5_MOUSE
Cytochrome b5
117
15232
4.96
9
4
3
1
3
0.43
1.94

ECI2_MOUSE
Enoyl-CoA delta isomerase 2, mitochondrial
117
43240
9.08
4
3
3
2
3
0.13
0.21

TCAF2_MOUSE
TRPM8 channel-associated factor 2
117
101532
6.07
5
5
3
3
3
0.06
0.13

RCN1_MOUSE
Reticulocalbin-1
117
38090
4.7
9
6
5
3
5
0.27
0.39

ELP1_MOUSE
Elongator complex protein 1
117
149489
5.67
9
2
6
1
6
0.09
0.03

NHLC2_MOUSE
NHL repeat-containing protein 2
117
78381
5.33
10
6
3
2
3
0.12
0.17

NQO2_MOUSE
Ribosyldihydronicotinamide dehydrogenase [quinone]
117
26231
6.54
6
4
4
3
4
0.32
0.61

C1TC_MOUSE
C-1-tetrahydrofolate synthase, cytoplasmic
116
101136
6.7
12
7
6
4
6
0.16
0.18

TWF1_MOUSE
Twinfilin-1
115
40054
6.21
7
3
7
3
6
0.36
0.37

HPCL1_MOUSE
Hippocalcin-like protein 1
115
22324
5.32
5
2
5
2
5
0.43
0.45

PEBP1_MOUSE
Phosphatidylethanolamine-binding protein 1
114
20817
5.19
16
6
5
3
5
0.57
0.81

FSTL1_MOUSE
Follistatin-related protein 1
114
34532
5.58
1
1
1
1
1
0.06
0.13

TIGAR_MOUSE
Fructose-2,6-bisphosphatase TIGAR
114
29172
8.45
3
2
2
1
2
0.16
0.15

HMOX1_MOUSE
Heme oxygenase 1
113
32908
6.08
14
6
4
3
4
0.3
0.46

FKB1A_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP1A
112
11915
7.88
10
5
4
3
4
0.66
1.79

GT251_MOUSE
Procollagen galactosyltransferase 1
112
71015
6.83
10
5
8
4
8
0.18
0.27

CD81_MOUSE
CD81 antigen
111
25797
5.54
5
4
2
2
2
0.18
0.38

IDH3A_MOUSE
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
111
39613
6.27
4
3
3
2
3
0.16
0.23

VMA5A_MOUSE
von Willebrand factor A domain-containing protein 5A
111
87087
6.15
6
5
4
3
4
0.09
0.15

LONM_MOUSE
Lon protease homolog, mitochondrial
111
105776
6.15
9
4
6
2
6
0.16
0.08

ECHB_MOUSE
Trifunctional enzyme subunit beta, mitochondrial
111
51353
9.43
10
2
6
2
6
0.23
0.18

SRPRA_MOUSE
Signal recognition particle receptor subunit alpha
110
69579
9.07
6
3
5
2
5
0.12
0.13

EIF3D_MOUSE
Eukaryotic translation initiation factor 3 subunit D
109
63948
5.79
8
4
5
2
5
0.2
0.14

CX6A1_MOUSE
Cytochrome c oxidase subunit 6A1, mitochondrial
109
12344
9.97
5
4
2
1
2
0.45
0.39

RISC_MOUSE
Retinoid-inducible serine carboxypeptidase
108
50932
5.48
16
8
10
6
10
0.3
0.77

PRDX2_MOUSE
Peroxiredoxin-2
108
21765
5.2
12
6
6
4
6
0.46
1.13

RL18_MOUSE
60S ribosomal protein L18
108
21631
11.79
2
2
2
2
2
0.14
0.46

PTGR3_MOUSE
Prostaglandin reductase-3
108
40503
7.01
6
5
3
3
3
0.23
0.51

PPID_MOUSE
Peptidyl-prolyl cis-trans isomerase D
108
40717
7.08
4
2
3
1
3
0.15
0.11

SGTA_MOUSE
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
106
34301
4.99
7
6
2
2
2
0.05
0.27

HYEP_MOUSE
Epoxide hydrolase 1
106
52543
8.43
28
6
15
3
15
0.43
0.37

RAGP1_MOUSE
Ran GTPase-activating protein 1
105
63491
4.59
10
5
8
5
8
0.21
0.39

NCBP1_MOUSE
Nuclear cap-binding protein subunit 1
105
91868
6.17
9
3
8
2
8
0.15
0.1

FKBP9_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP9
104
62956
5.03
10
5
6
4
6
0.17
0.3

NB5R3_MOUSE
NADH-cytochrome b5 reductase 3
104
34106
8.55
13
5
7
5
7
0.55
0.84

CX6B1_MOUSE
Cytochrome c oxidase subunit 6B1
104
10065
8.96
4
3
2
2
2
0.29
1.23

COMT_MOUSE
Catechol O-methyltransferase
104
29467
5.52
10
7
4
3
4
0.24
0.53

BIN1_MOUSE
Myc box-dependent-interacting protein 1
103
64430
4.95
10
3
7
2
7
0.22
0.14

AN32B_MOUSE
Acidic leucine-rich nuclear phosphoprotein 32 family member B
102
31060
3.89
6
3
3
2
3
0.16
0.31

TIF1B_MOUSE
Transcription intermediary factor 1-beta
101
88791
5.52
6
4
3
3
3
0.06
0.15

SH3L2_MOUSE
SH3 domain-binding glutamic acid-rich-like protein 2
101
12247
5.48
3
3
2
2
2
0.26
0.95

ERO1A_MOUSE
ERO1-like protein alpha
101
54050
6.12
8
5
5
4
5
0.15
0.36

LMNA_MOUSE
Prelamin-A/C
101
74193
6.54
16
4
11
3
11
0.26
0.18

ODPB_MOUSE
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
101
38912
6.41
6
4
5
4
5
0.29
0.53

MPPA_MOUSE
Mitochondrial-processing peptidase subunit alpha
100
58242
6.36
2
1
1
1
1
0.03
0.07

EIF2A_MOUSE
Eukaryotic translation initiation factor 2A
100
64363
9.04
8
4
6
3
6
0.2
0.21

GSHR_MOUSE
Glutathione reductase, mitochondrial
100
53629
8.19
5
3
3
1
3
0.15
0.08

ADPRH_MOUSE
[Protein ADP-ribosylarginine] hydrolase
99
40042
5.46
8
5
3
3
3
0.22
0.37

DDX58_MOUSE
Probable ATP-dependent RNA helicase DDX58
99
105908
6.23
9
4
4
2
4
0.09
0.08

AP1M1_MOUSE
AP-1 complex subunit mu-1
99
48512
6.82
4
3
2
2
2
0.09
0.19

MVP_MOUSE
Major vault protein
98
95865
5.43
11
4
7
3
7
0.18
0.14

COPE_MOUSE
Coatomer subunit epsilon
98
34545
4.94
24
6
6
2
6
0.4
0.27

DPP2_MOUSE
Dipeptidyl peptidase 2
98
56218
5.17
3
2
2
1
2
0.07
0.08

PURA2_MOUSE
Adenylosuccinate synthetase isozyme 2
98
49990
5.98
12
3
7
3
7
0.25
0.28

PGS2_MOUSE
Decorin
98
39784
8.87
5
2
3
1
3
0.15
0.11

COPB2_MOUSE
Coatomer subunit beta
98
102384
5.17
19
8
12
6
12
0.27
0.28

HCDH_MOUSE
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
97
34442
8.76
5
3
4
2
4
0.23
0.27

CTBP1_MOUSE
C-terminal-binding protein 1
97
47715
6.28
6
3
3
1
3
0.12
0.09

BAG6_MOUSE
Large proline-rich protein BAG6
97
120962
5.46
6
2
4
2
4
0.08
0.07

MAP1B_MOUSE
Microtubule-associated protein 1B
97
270089
4.76
16
5
13
3
13
0.11
0.05

ATX10_MOUSE
Ataxin-10
97
53673
5.12
11
5
5
3
5
0.19
0.26

PRRC1_MOUSE
Protein PRRC1
97
46268
5.62
9
4
6
3
6
0.28
0.31

RRAS_MOUSE
Ras-related protein R-Ras
97
23749
6.32
4
3
3
2
3
0.22
0.42

CPT1A_MOUSE
Carnitine O-palmitoyltransferase 1, liver isoform
97
88195
8.83
4
2
2
2
2
0.09
0.1

SPRE_MOUSE
Sepiapterin reductase
97
27865
5.58
3
3
2
2
2
0.22
0.35

NEK7_MOUSE
Serine/threonine-protein kinase Nek7
96
34514
8.49
3
2
2
1
2
0.16
0.13

FACE1_MOUSE
CAAX prenyl protease 1 homolog
95
54699
6.49
6
2
4
1
4
0.17
0.08

STAM2_MOUSE
Signal transducing adapter molecule 2
95
57419
4.94
7
6
3
2
3
0.15
0.24

TMED5_MOUSE
Transmembrane emp24 domain-containing protein 5
94
26155
4.81
3
3
1
1
1
0.12
0.17

SYDC_MOUSE
Aspartate–tRNA ligase, cytoplasmic
94
57111
6.07
13
3
9
3
9
0.28
0.24

ACADM_MOUSE
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
94
46452
8.6
3
3
2
2
2
0.11
0.2

PDCL3_MOUSE
Phosducin-like protein 3
94
27564
4.66
7
5
4
3
4
0.36
0.57

SYWC_MOUSE
Tryptophan–tRNA ligase, cytoplasmic
94
54323
6.44
10
4
5
1
5
0.2
0.08

NIBL1_MOUSE
Niban-like protein 1
94
84765
5.65
14
8
7
5
7
0.15
0.34

CYB5B_MOUSE
Cytochrome b5 type B
94
16308
4.79
3
2
1
1
1
0.23
0.29

TNPO1_MOUSE
Transportin-1
93
102291
4.84
17
9
12
6
9
0.28
0.28

SCFD1_MOUSE
Sec1 family domain-containing protein 1
93
72277
5.98
8
3
5
3
5
0.19
0.19

PRDX5_MOUSE
Peroxiredoxin-5, mitochondrial
93
21884
9.1
13
3
7
3
7
0.48
0.76

PUR8_MOUSE
Adenylosuccinate lyase
92
54831
6.9
7
5
6
4
6
0.23
0.36

IAH1_MOUSE
Isoamyl acetate-hydrolyzing esterase 1 homolog
92
27956
5.34
3
2
1
1
1
0.07
0.16

VA0D1_MOUSE
V-type proton ATPase subunit d 1
91
40275
4.89
5
3
5
3
5
0.33
0.36

CMTD1_MOUSE
Catechol O-methyltransferase domain-containing protein 1
91
28943
8.61
2
2
1
1
1
0.1
0.15

AIFM1_MOUSE
Apoptosis-inducing factor 1, mitochondrial
90
66724
9.23
4
2
3
2
3
0.1
0.13

MSMO1_MOUSE
Methylsterol monooxygenase 1
90
34750
7.29
8
3
5
2
5
0.31
0.43

PON2_MOUSE
Serum paraoxonase/arylesterase 2
90
39592
5.49
2
1
2
1
2
0.1
0.11

LTOR3_MOUSE
Ragulator complex protein LAMTOR3
90
13544
6.73
4
3
3
2
3
0.4
0.83

ACACA_MOUSE
Acetyl-CoA carboxylase 1
90
265088
5.97
12
4
10
3
10
0.09
0.07

PGPI_MOUSE
Pyroglutamyl-peptidase 1
90
22919
5.21
4
4
2
2
2
0.21
0.43

CTND1_MOUSE
Catenin delta-1
89
104860
6.41
9
6
5
2
5
0.12
0.08

NDUA9_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
89
42498
9.75
6
4
4
2
4
0.16
0.22

PMM2_MOUSE
Phosphomannomutase 2
89
27639
6.01
2
2
1
1
1
0.11
0.16

FAAA_MOUSE
Fumarylacetoacetase
89
46146
6.7
4
4
3
3
3
0.16
0.31

TCP4_MOUSE
Activated RNA polymerase II transcriptional coactivator p15
89
14418
9.6
2
2
1
1
1
0.19
0.33

IDHP_MOUSE
Isocitrate dehydrogenase [NADP], mitochondrial
89
50874
8.88
12
4
7
3
6
0.27
0.39

DUS3_MOUSE
Dual specificity protein phosphatase 3
89
20459
6.07
2
1
2
1
2
0.19
0.22

LIMA1_MOUSE
LIM domain and actin-binding protein 1
88
84008
6.18
6
2
4
1
4
0.09
0.05

MESD_MOUSE
LRP chaperone MESD
88
25191
6.06
4
3
3
2
3
0.23
0.39

CYGB_MOUSE
Cytoglobin
88
21452
6.32
2
2
1
1
1
0.13
0.21

MA2A1_MOUSE
Alpha-mannosidase 2
88
131548
8.17
9
4
8
4
8
0.14
0.14

DPP3_MOUSE
Dipeptidyl peptidase 3
88
82846
5.26
11
8
7
5
7
0.22
0.29

NDUC2_MOUSE
NADH dehydrogenase [ubiquinone] 1 subunit C2
87
14154
9.24
2
2
1
1
1
0.16
0.33

CNPY4_MOUSE
Protein canopy homolog 4
86
28076
4.72
5
3
3
2
3
0.22
0.34

CATH_MOUSE
Pro-cathepsin H
86
37146
8.68
3
2
2
1
2
0.14
0.12

PSMD8_MOUSE
26S proteasome non-ATPase regulatory subunit 8
86
39905
9.61
9
3
6
2
6
0.4
0.23

RCC1_MOUSE
Regulator of chromosome condensation
86
44903
8.34
5
3
4
2
4
0.19
0.2

ORN_MOUSE
Oligoribonuclease, mitochondrial
86
26722
6.67
2
1
2
1
2
0.18
0.17

G6PC3_MOUSE
Glucose-6-phosphatase 3
86
38756
8.42
2
2
2
2
2
0.1
0.24

IMA5_MOUSE
Importin subunit alpha-5
86
60144
4.93
5
4
2
2
2
0.11
0.15

PSMD4_MOUSE
26S proteasome non-ATPase regulatory subunit 4
86
40678
4.67
7
4
4
2
4
0.17
0.23

GSTT3_MOUSE
Glutathione S-transferase theta-3
85
27385
7.63
3
3
1
1
1
0.14
0.16

PSA1_MOUSE
Proteasome subunit alpha type-1
85
29528
6
9
6
6
3
6
0.41
0.75

GPNMB_MOUSE
Transmembrane glycoprotein NMB
85
63635
7.55
6
4
3
3
3
0.06
0.22

FUBP2_MOUSE
Far upstream element-binding protein 2
84
76728
6.9
9
3
6
2
6
0.12
0.12

RS21_MOUSE
40S ribosomal protein S21
84
9136
8.71
6
3
1
1
1
0.17
0.56

ABRAL_MOUSE
Costars family protein ABRACL
84
9025
5.52
5
1
2
1
2
0.46
0.56

UMPS_MOUSE
Uridine 5-monophosphate synthase
84
52259
6.17
7
3
3
2
3
0.15
0.17

PSA3_MOUSE
Proteasome subunit alpha type-3
84
28387
5.29
3
2
2
1
2
0.11
0.16

HGS_MOUSE
Hepatocyte growth factor-regulated tyrosine kinase substrate
83
85961
5.84
10
2
7
2
7
0.17
0.1

RIR1_MOUSE
Ribonucleoside-diphosphate reductase large subunit
83
90153
6.27
8
2
6
2
6
0.16
0.1

PGH2_MOUSE
Prostaglandin G/H synthase 2
83
68969
7
9
3
6
2
6
0.21
0.13

CSDE1_MOUSE
Cold shock domain-containing protein E1
83
88735
5.97
5
1
5
1
5
0.12
0.05

SAE1_MOUSE
SUMO-activating enzyme subunit 1
82
38596
5.24
9
6
3
3
3
0.17
0.38

NPS3B_MOUSE
Protein NipSnap homolog 3B
82
28290
9.51
3
3
1
1
1
0.11
0.16

TBCD_MOUSE
Tubulin-specific chaperone D
82
133236
6.08
5
4
4
3
4
0.08
0.1

COR1C_MOUSE
Coronin-1C
82
53087
6.65
7
3
5
3
5
0.17
0.27

SCMC1_MOUSE
Calcium-binding mitochondrial carrier protein SCaMC-1
82
52868
7.02
9
4
4
1
4
0.15
0.08

ECM29_MOUSE
Proteasome-associated protein ECM29 homolog
82
203573
6.68
21
7
16
6
16
0.18
0.13

LICH_MOUSE
Lysosomal acid lipase/cholesteryl ester hydrolase
81
45296
8.16
4
3
3
2
3
0.15
0.2

IMA7_MOUSE
Importin subunit alpha-7
81
59926
4.86
9
4
6
4
6
0.29
0.32

CLPT1_MOUSE
Cleft lip and palate transmembrane protein 1 homolog
81
75243
5.88
4
1
3
1
3
0.11
0.06

RWDD1_MOUSE
RWD domain-containing protein 1
81
27768
4.18
6
4
3
2
3
0.3
0.35

DDX21_MOUSE
Nucleolar RNA helicase 2
80
93493
9.19
7
5
3
2
3
0.08
0.09

XPO5_MOUSE
Exportin-5
80
136883
5.57
16
8
7
3
7
0.11
0.13

SDCB1_MOUSE
Syntenin-1
80
32359
6.66
9
5
4
2
4
0.25
0.29

GLOD4_MOUSE
Glyoxalase domain-containing protein 4
80
33296
5.28
8
5
3
2
3
0.19
0.28

PLD3_MOUSE
Phospholipase D3
80
54354
6.07
10
4
7
3
7
0.34
0.36

LARP1_MOUSE
La-related protein 1
80
121050
8.87
6
3
4
1
4
0.05
0.04

NDUAA_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
80
40578
7.63
2
2
2
2
2
0.09
0.23

EIF3C_MOUSE
Eukaryotic translation initiation factor 3 subunit C
80
105465
5.55
14
4
10
3
10
0.18
0.13

GNPI1_MOUSE
Glucosamine-6-phosphate isomerase 1
79
32528
6.13
5
3
3
3
3
0.21
0.47

ADDA_MOUSE
Alpha-adducin
79
80596
5.62
6
2
4
1
4
0.12
0.05

SEPT5_MOUSE
Septin-5
79
42721
6.21
16
5
9
4
9
0.42
0.63

TADBP_MOUSE
TAR DNA-binding protein 43
79
44519
6.26
3
3
1
1
1
0.07
0.1

MAP4_MOUSE
Microtubule-associated protein 4
79
117357
4.9
7
2
5
1
5
0.09
0.04

RAB9A_MOUSE
Ras-related protein Rab-9A
79
22895
5.43
4
4
2
2
2
0.19
0.43

AGAL_MOUSE
Alpha-galactosidase A
79
47611
5.44
6
4
5
3
5
0.21
0.3

ULA1_MOUSE
NEDD8-activating enzyme E1 regulatory subunit
78
60236
5.34
4
3
3
2
3
0.15
0.15

EI2BA_MOUSE
Translation initiation factor eIF-2B subunit alpha
78
33795
8.48
4
2
3
2
3
0.17
0.28

LPPRC_MOUSE
Leucine-rich PPR motif-containing protein, mitochondrial
78
156516
6.42
10
6
7
4
7
0.12
0.11

SYK_MOUSE
Lysine–tRNA ligase
78
67796
5.65
10
5
6
4
6
0.17
0.28

SWI5_MOUSE
DNA repair protein SWI5 homolog
78
10254
4.67
1
1
1
1
1
0.19
0.49

FAM3C_MOUSE
Protein FAM3C
77
24737
8.52
5
2
2
1
2
0.13
0.18

BLMH_MOUSE
Bleomycin hydrolase
77
52477
6.04
8
3
6
2
6
0.26
0.17

TOIP1_MOUSE
Torsin-1A-interacting protein 1
77
66740
6.58
2
2
2
2
2
0.04
0.13

NUDC_MOUSE
Nuclear migration protein nudC
77
38334
5.17
2
1
2
1
2
0.06
0.11

GSHB_MOUSE
Glutathione synthetase
77
52214
5.56
4
3
3
2
3
0.14
0.17

SPTC2_MOUSE
Serine palmitoyltransferase 2
77
62941
8.43
8
4
4
1
4
0.14
0.07

CP20A_MOUSE
Cytochrome P450 20A1
77
52116
6.48
4
2
3
1
3
0.13
0.08

USP9X_MOUSE
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
76
290526
5.57
19
6
10
3
10
0.08
0.04

ASPH_MOUSE
Aspartyl/asparaginyl beta-hydroxylase
75
82991
4.97
9
4
8
4
8
0.17
0.22

ALDR_MOUSE
Aldose reductase
76
35709
6.71
4
2
3
1
3
0.19
0.12

MGAT1_MOUSE
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
76
51658
9.02
6
5
2
2
2
0.12
0.18

ATP5H_MOUSE
ATP synthase subunit d, mitochondrial
76
18738
5.52
5
3
4
3
4
0.42
0.93

AT5F1_MOUSE
ATP synthase F(0) complex subunit B1, mitochondrial
76
28930
9.11
5
1
5
1
5
0.34
0.15

IF2B_MOUSE
Eukaryotic translation initiation factor 2 subunit 2
76
38068
5.61
6
3
4
2
4
0.19
0.24

HEAT3_MOUSE
HEAT repeat-containing protein 3
75
74258
4.91
5
3
3
2
3
0.08
0.12

LCLT1_MOUSE
Lysocardiolipin acyltransferase 1
75
44371
8.77
2
2
2
2
2
0.14
0.21

MCM6_MOUSE
DNA replication licensing factor MCM6
75
92809
5.32
4
3
4
3
4
0.09
0.14

NDUA8_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
75
19979
8.76
3
2
2
1
2
0.23
0.23

POSTN_MOUSE
Periostin
75
93085
7.27
11
4
6
2
6
0.18
0.09

ACDSB_MOUSE
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
74
47843
8
4
1
3
1
3
0.13
0.09

EIF1_MOUSE
Eukaryotic translation initiation factor 1
74
12739
6.89
2
1
2
1
2
0.33
0.38

IF1A_MOUSE
Eukaryotic translation initiation factor 1A
73
16492
5.07
4
1
4
1
1
0.26
0.28

CHMP5_MOUSE
Charged multivesicular body protein 5
73
24560
4.65
2
2
1
1
1
0.12
0.18

S10A4_MOUSE
Protein S100-A4
73
11714
5.23
6
5
3
3
3
0.25
1.82

ITM2C_MOUSE
Integral membrane protein 2C
73
30463
8.83
2
2
1
1
1
0.08
0.15

MEP50_MOUSE
Methylosome protein 50
73
36919
5.09
2
2
1
1
1
0.09
0.12

NDUS8_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
73
24023
5.89
3
3
2
2
2
0.09
0.41

ZFPL1_MOUSE
Zinc finger protein-like 1
73
34133
8.57
7
2
3
2
3
0.2
0.27

USMG5_MOUSE
Upregulated during skeletal muscle growth protein 5
72
6377
9.84
2
2
1
1
1
0.26
0.87

VATL_MOUSE
V-type proton ATPase 16 kDa proteolipid subunit
72
15798
9.1
1
1
1
1
1
0.2
0.3

SFRP1_MOUSE
Secreted frizzled-related protein 1
72
35389
9.17
3
2
2
1
2
0.12
0.12

AAAS_MOUSE
Aladin
72
59393
6.39
3
3
1
1
1
0.03
0.07

ABD12_MOUSE
Monoacylglycerol lipase ABHD12
72
45241
8.9
3
1
2
1
2
0.07
0.1

SYIM_MOUSE
Isoleucine–tRNA ligase, mitochondrial
72
112732
6.37
7
5
5
3
5
0.11
0.12

MAPK2_MOUSE
MAP kinase-activated protein kinase 2
71
44022
8.77
7
2
5
2
5
0.19
0.21

BIEA_MOUSE
Biliverdin reductase A
71
33504
6.53
6
5
4
4
4
0.25
0.64

AP3D1_MOUSE
AP-3 complex subunit delta-1
71
134996
7.04
4
3
3
2
3
0.04
0.06

ALG5_MOUSE
Dolichyl-phosphate beta-glucosyltransferase
71
36767
8.83
4
2
2
2
2
0.12
0.25

CD99_MOUSE
CD99 antigen
71
16772
5.14
2
2
1
1
1
0.27
0.28

SYQ_MOUSE
Glutamine–tRNA ligase
70
87621
6.93
8
2
5
2
5
0.12
0.1

TCEA1_MOUSE
Transcription elongation factor A protein 1
70
33859
8.64
5
5
1
1
1
0.09
0.13

XDH_MOUSE
Xanthine dehydrogenase/oxidase
70
146468
7.62
14
6
6
3
6
0.1
0.12

ANXA7_MOUSE
Annexin A7
70
49893
5.91
5
2
5
2
5
0.16
0.18

IPYR2_MOUSE
Inorganic pyrophosphatase 2, mitochondrial
70
38090
6.51
8
3
5
2
5
0.16
0.24

CY1_MOUSE
Cytochrome c1, heme protein, mitochondrial
70
35305
9.24
2
1
2
1
2
0.12
0.12

NP1L4_MOUSE
Nucleosome assembly protein 1-like 4
70
42653
4.56
6
3
5
3
4
0.24
0.34

NU133_MOUSE
Nuclear pore complex protein Nup133
70
128539
5.06
5
2
5
2
5
0.09
0.07

SIAS_MOUSE
Sialic acid synthase
70
39998
6.61
2
1
1
1
1
0.1
0.11

ETFA_MOUSE
Electron transfer flavoprotein subunit alpha, mitochondrial
69
34988
8.62
10
5
5
3
5
0.33
0.43

GALM_MOUSE
Aldose 1-epimerase
69
37775
6.26
3
1
2
1
2
0.12
0.12

ABCF1_MOUSE
ATP-binding cassette sub-family F member 1
69
94887
6.15
3
2
2
1
2
0.06
0.05

T176B_MOUSE
Transmembrane protein 176B
68
28349
8.03
2
1
2
1
2
0.22
0.16

ICAL_MOUSE
Calpastatin
68
84871
5.37
6
3
4
2
4
0.1
0.1

THIM_MOUSE
3-Ketoacyl-CoA thiolase, mitochondrial
68
41803
8.33
3
1
3
1
3
0.13
0.1

CAPR1_MOUSE
Caprin-1
67
78121
5.14
7
2
5
2
5
0.11
0.11

PTPA_MOUSE
Serine/threonine-protein phosphatase 2A activator
67
36687
5.95
2
2
2
2
2
0.11
0.25

ATP5L_MOUSE
ATP synthase subunit g, mitochondrial
67
11417
9.74
3
2
2
1
2
0.32
0.43

UBA6_MOUSE
Ubiquitin-like modifier-activating enzyme 6
67
117891
5.75
7
1
6
1
6
0.11
0.04

VASP_MOUSE
Vasodilator-stimulated phosphoprotein
67
39642
8.69
5
2
3
2
3
0.08
0.23

E41L2_MOUSE
Band 4.1-like protein 2
67
109873
5.31
8
4
5
3
5
0.07
0.12

GLRX3_MOUSE
Glutaredoxin-3
67
37754
5.42
16
7
8
6
8
0.46
0.94

TRXR1_MOUSE
Thioredoxin reductase 1, cytoplasmic
66
67042
7.42
12
4
6
2
6
0.19
0.13

IASPP_MOUSE
RelA-associated inhibitor
66
88921
6.39
3
1
3
1
3
0.1
0.05

NUP85_MOUSE
Nuclear pore complex protein Nup85
66
74728
5.37
6
3
4
1
4
0.09
0.06

DDX18_MOUSE
ATP-dependent RNA helicase DDX18
66
74134
9.54
6
4
3
2
3
0.07
0.12

NEUL_MOUSE
Neurolysin, mitochondrial
66
80378
6.01
10
4
7
2
7
0.18
0.11

MLEC_MOUSE
Malectin
66
32322
5.73
8
3
6
2
6
0.37
0.47

GPC4_MOUSE
Glypican-4
65
62546
5.96
3
1
3
1
3
0.13
0.07

KIME_MOUSE
Mevalonate kinase
65
41851
6.22
4
3
2
1
2
0.14
0.1

EIF3L_MOUSE
Eukaryotic translation initiation factor 3 subunit L
65
66570
6.01
5
3
4
2
4
0.13
0.13

G3BP1_MOUSE
Ras GTPase-activating protein-binding protein 1
65
51797
5.41
10
3
9
3
9
0.31
0.27

CTNB1_MOUSE
Catenin beta-1
64
85416
5.53
10
3
5
2
5
0.13
0.1

ACADL_MOUSE
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
64
47877
8.53
10
3
5
3
3
0.17
0.3

HXK1_MOUSE
Hexokinase-1
64
108234
6.37
7
3
6
3
6
0.09
0.12

TF_MOUSE
Tissue factor
64
32914
9.4
2
2
1
1
1
0.09
0.13

MYEF2_MOUSE
Myelin expression factor 2
64
63254
8.96
3
1
3
1
3
0.05
0.07

ANM5_MOUSE
Protein arginine N-methyltransferase 5
64
72634
5.99
16
3
7
1
7
0.25
0.12

MED11_MOUSE
Mediator of RNA polymerase II transcription subunit 11
63
13123
5.71
3
3
1
1
1
0.21
0.86

HEAT6_MOUSE
HEAT repeat-containing protein 6
63
128840
6.88
5
3
3
1
3
0.06
0.03

NAMPT_MOUSE
Nicotinamide phosphoribosyltransferase
63
55413
6.69
3
2
2
2
2
0.09
0.16

MYO9B_MOUSE
Unconventional myosin-Ixb
63
238685
8.82
3
1
3
1
3
0.03
0.02

AL1L2_MOUSE
Mitochondrial 10-formyltetrahydrofolate dehydrogenase
63
101526
5.93
5
1
4
1
4
0.08
0.04

HSBP1_MOUSE
Heat shock factor-binding protein 1
63
8605
4.11
2
1
1
1
1
0.25
0.59

MYG1_MOUSE
UPF0160 protein MYG1, mitochondrial
63
42696
6.54
1
1
1
1
1
0.04
0.1

RBM3_MOUSE
RNA-binding protein 3
62
16595
6.84
11
4
4
2
4
0.46
0.64

SLIT3_MOUSE
Slit homolog 3 protein
62
167617
7.95
13
2
7
2
7
0.11
0.05

PPM1B_MOUSE
Protein phosphatase 1B
62
42768
5.04
3
1
2
1
2
0.11
0.1

DPEP1_MOUSE
Dipeptidase 1
62
45693
5.9
4
1
3
1
3
0.23
0.1

F10A1_MOUSE
Hsc70-interacting protein
62
41630
5.19
6
3
3
2
3
0.12
0.22

MCFD2_MOUSE
Multiple coagulation factor deficiency protein 2 homolog
62
16158
4.55
1
1
1
1
1
0.17
0.29

RM12_MOUSE
39S ribosomal protein L12, mitochondrial
62
21695
9.34
8
2
3
1
3
0.2
0.46

FDFT_MOUSE
Squalene synthase
61
48123
5.91
5
2
2
2
2
0.06
0.19

LGUL_MOUSE
Lactoylglutathione lyase
61
20796
5.24
8
3
4
1
4
0.33
0.22

CDK4_MOUSE
Cyclin-dependent kinase 4
54
33729
6.16
6
2
5
2
5
0.31
0.28

CDC37_MOUSE
Hsp90 co-chaperone Cdc37
61
44565
5.24
4
2
3
2
2
0.13
0.21

CDK1_MOUSE
Cyclin-dependent kinase 1
61
34085
8.39
10
6
5
3
5
0.27
0.44

LETM1_MOUSE
Mitochondrial proton/calcium exchanger protein
61
82937
6.16
7
1
6
1
6
0.15
0.05

PGM1_MOUSE
Phosphoglucomutase-1
60
61380
6.14
6
3
6
3
6
0.29
0.23

LAMP2_MOUSE
Lysosome-associated membrane glycoprotein 2
60
45652
7.05
12
4
8
3
8
0.25
0.31

PKD2_MOUSE
Polycystin-2
60
108914
5.47
4
1
4
1
4
0.08
0.04

UCHL1_MOUSE
Ubiquitin carboxyl-terminal hydrolase isozyme L1
60
24822
5.14
7
4
5
3
5
0.38
0.65

COPD_MOUSE
Coatomer subunit delta
60
57193
5.89
18
4
12
3
12
0.34
0.24

IRGM1_MOUSE
Immunity-related GTPase family M protein 1
60
46522
8.56
4
3
2
1
2
0.13
0.09

AKA12_MOUSE
A-kinase anchor protein 12
60
180586
4.39
11
2
5
2
5
0.05
0.05

MP2K4_MOUSE
Dual specificity mitogen-activated protein kinase 4
60
44085
8.28
5
2
5
2
5
0.27
0.21

NCLN_MOUSE
Nicalin
59
62868
6.03
3
2
2
2
2
0.06
0.14

LMF2_MOUSE
Lipase maturation factor 2
58
79947
9.99
4
3
2
2
2
0.06
0.11

FHL1_MOUSE
Four and a half LIM domains protein 1
59
31867
8.76
6
3
3
2
3
0.17
0.3

ARHG7_MOUSE
Rho guanine nucleotide exchange factor 7
59
96995
6.35
2
1
2
1
2
0.04
0.04

PP14B_MOUSE
Protein phosphatase 1 regulatory subunit 14B
59
15947
4.74
10
6
2
2
2
0.29
0.67

MANF_MOUSE
Mesencephalic astrocyte-derived neurotrophic factor
59
20361
8.34
12
4
3
3
3
0.21
0.84

ACOT2_MOUSE
Acyl-coenzyme A thioesterase 2, mitochondrial
59
49626
6.88
4
3
2
2
2
0.08
0.18

S23IP_MOUSE
SEC23-interacting protein
59
110711
5.63
11
6
6
3
6
0.14
0.12

ERP29_MOUSE
Endoplasmic reticulum resident protein 29
58
28805
5.9
7
3
2
2
2
0.14
0.33

CO6A1_MOUSE
Collagen alpha-1(VI) chain
58
108422
5.2
5
2
4
1
4
0.1
0.04

DBNL_MOUSE
Drebrin-like protein
58
48670
4.9
4
2
2
1
2
0.1
0.09

SCPDL_MOUSE
Saccharopine dehydrogenase-like oxidoreductase
58
47099
8.86
6
3
3
1
3
0.2
0.09

PP1R7_MOUSE
Protein phosphatase 1 regulatory subunit 7
58
41266
4.85
5
3
2
1
2
0.14
0.22

MGST1_MOUSE
Microsomal glutathione S-transferase 1
58
17540
9.67
2
1
1
1
1
0.21
0.26

MON2_MOUSE
Protein MON2 homolog
58
188958
5.77
6
2
5
2
5
0.08
0.05

PARK7_MOUSE
Protein/nucleic acid deglycase DJ-1
57
20008
6.32
3
2
3
2
3
0.27
0.51

WASC4_MOUSE
WASH complex subunit 4
57
136283
6.99
5
2
5
2
5
0.09
0.06

AKAP1_MOUSE
A-kinase anchor protein 1, mitochondrial
57
92137
4.91
2
1
2
1
2
0.03
0.05

MALD1_MOUSE
MARVEL domain-containing protein 1
57
19074
9.77
5
3
2
1
2
0.21
0.24

SPEE_MOUSE
Spermidine synthase
57
33973
5.31
7
3
5
3
5
0.3
0.44

RFIP5_MOUSE
Rab11 family-interacting protein 5
57
69510
9.17
5
3
2
1
2
0.04
0.06

EXOC1_MOUSE
Exocyst complex component 1
57
101825
6.09
6
3
5
2
5
0.13
0.09

DOCK7_MOUSE
Dedicator of cytokinesis protein 7
56
241286
6.25
15
2
8
2
8
0.08
0.04

NDUA4_MOUSE
Cytochrome c oxidase subunit NDUFA4
56
9321
9.52
4
2
2
1
2
0.46
0.54

TGFI1_MOUSE
Transforming growth factor beta-1-induced transcript 1 protein
56
50068
6.28
8
4
3
2
3
0.18
0.18

HUWE1_MOUSE
E3 ubiquitin-protein ligase HUWE1
56
482332
5.1
10
2
9
1
9
0.04
0.01

LBR_MOUSE
Lamin-B receptor
56
71395
9.43
4
1
4
1
4
0.09
0.06

MARC2_MOUSE
Mitochondrial amidoxime reducing component 2
56
38170
8.95
4
2
3
2
3
0.18
0.24

CMC1_MOUSE
Calcium-binding mitochondrial carrier protein Aralar1
56
74523
8.43
4
3
2
2
2
0.05
0.12

BAX_MOUSE
Apoptosis regulator BAX
56
21381
4.86
1
1
1
1
1
0.07
0.21

BASP1_MOUSE
Brain acid soluble protein 1
56
22074
4.5
14
2
1
1
1
0.14
0.21

HINT1_MOUSE
Histidine triad nucleotide-binding protein 1
56
13768
6.36
4
1
4
1
4
0.6
0.35

SCYL1_MOUSE
N-terminal kinase-like protein
56
89104
6.03
2
1
2
1
2
0.06
0.05

QCR2_MOUSE
Cytochrome b-c1 complex subunit 2, mitochondrial
55
48205
9.26
2
1
2
1
2
0.08
0.09

TMF1_MOUSE
TATA element modulatory factor
55
121729
4.83
4
1
4
1
4
0.07
0.03

RENT1_MOUSE
Regulator of nonsense transcripts 1
55
123889
6.18
7
2
6
2
6
0.13
0.07

IKIP_MOUSE
Inhibitor of nuclear factor kappa-B kinase-interacting protein
55
42505
5.03
6
4
4
3
4
0.19
0.34

HPRT_MOUSE
Hypoxanthine-guanine phosphoribosyltransferase
53
24555
6.21
6
4
3
3
2
0.32
0.66

ISC2A_MOUSE
Isochorismatase domain-containing protein 2A
55
22403
8.25
1
1
1
1
1
0.13
0.2

NU4M_MOUSE
NADH-ubiquinone oxidoreductase chain 4
55
51847
9.42
3
1
2
1
2
0.04
0.08

CTL2_MOUSE
Choline transporter-like protein 2
55
80057
9.06
5
4
1
1
1
0.02
0.05

JIP4_MOUSE
C-Jun-amino-terminal kinase-interacting protein 4
54
146129
5.05
8
2
6
2
6
0.09
0.06

5NT3B_MOUSE
7-Methylguanosine phosphate-specific 5-nucleotidase
54
34403
5.82
1
1
1
1
1
0.07
0.13

LAP2A_MOUSE
Lamina-associated polypeptide 2, isoforms alpha/zeta
54
75122
8.29
4
1
2
1
2
0.05
0.06

EM55_MOUSE
55 kDa erythrocyte membrane protein
54
52194
6.72
6
3
4
3
4
0.16
0.27

KAP0_MOUSE
cAMP-dependent protein kinase type I-alpha regulatory subunit
54
43158
5.27
5
2
3
1
3
0.15
0.1

GDIR2_MOUSE
Rho GDP-dissociation inhibitor 2
54
22836
4.97
7
4
4
3
4
0.26
0.72

NDUS2_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
54
52592
6.52
4
1
3
1
3
0.14
0.08

SYHC_MOUSE
Histidine–tRNA ligase, cytoplasmic
53
57396
5.79
4
3
4
3
4
0.17
0.24

IVD_MOUSE
Isovaleryl-CoA dehydrogenase, mitochondrial
54
46296
8.53
10
2
4
2
4
0.26
0.2

DHRS1_MOUSE
Dehydrogenase/reductase SDR family member 1
54
33983
8.66
1
1
1
1
1
0.06
0.13

SRP68_MOUSE
Signal recognition particle subunit SRP68
53
70530
8.77
5
1
5
1
5
0.13
0.06

PREP_MOUSE
Presequence protease, mitochondrial
53
117297
6.76
6
4
6
4
6
0.13
0.15

GUAA_MOUSE
GMP synthase [glutamine-hydrolyzing]
53
76675
6.29
3
2
2
1
2
0.09
0.06

NT5C_MOUSE
5(3)-Deoxyribonucleotidase, cytosolic type
53
23062
5.31
2
1
2
1
2
0.2
0.2

DNMT1_MOUSE
DNA (cytosine-5)-methyltransferase 1
53
183074
7.92
6
1
6
1
6
0.08
0.02

GALK1_MOUSE
Galactokinase
53
42268
5.17
2
1
2
1
2
0.07
0.1

PSD12_MOUSE
26S proteasome non-ATPase regulatory subunit 12
53
52861
6.66
11
3
8
3
8
0.25
0.27

GLMP_MOUSE
Glycosylated lysosomal membrane protein
52
43776
5.73
4
1
3
1
3
0.18
0.1

UD17C_MOUSE
UDP-glucuronosyltransferase 1-7C
52
59719
8.64
6
3
5
3
5
0.18
0.23

DHPR_MOUSE
Dihydropteridine reductase
52
25554
7.67
3
1
2
1
2
0.19
0.18

NAA25_MOUSE
N-Alpha-acetyltransferase 25, NatB auxiliary subunit
52
111637
6.1
2
1
2
1
2
0.04
0.04

LDAH_MOUSE
Lipid droplet-associated hydrolase
52
37349
8.5
4
2
3
1
3
0.22
0.12

TR10B_MOUSE
Tumor necrosis factor receptor superfamily member 10B
52
42138
6.75
1
1
1
1
1
0.06
0.1

BAG2_MOUSE
BAG family molecular chaperone regulator 2
52
23459
6.01
7
1
5
1
5
0.38
0.19

DNPEP_MOUSE
Aspartyl aminopeptidase
52
52174
6.82
10
4
3
1
3
0.19
0.17

ODO2_MOUSE
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
52
48963
9.11
4
2
2
1
2
0.07
0.09

TBCB_MOUSE
Tubulin-folding cofactor B
52
27368
5.14
2
2
1
1
1
0.08
0.16

PNKP_MOUSE
Bifunctional polynucleotide phosphatase/kinase
51
57188
8.03
1
1
1
1
1
0.04
0.08

ASAH1_MOUSE
Acid ceramidase
51
44641
8.68
10
4
6
3
6
0.24
0.32

VATE1_MOUSE
V-type proton ATPase subunit E 1
51
26141
8.44
4
2
3
1
3
0.3
0.17

ITPA_MOUSE
Inosine triphosphate pyrophosphatase
51
21883
5.6
4
1
2
1
2
0.15
0.21

MCM2_MOUSE
DNA replication licensing factor MCM2
51
102013
5.49
6
2
4
1
4
0.09
0.04

B2MG_MOUSE
Beta-2-microglobulin
50
13770
8.55
2
1
2
1
2
0.31
0.35

MRCKB_MOUSE
Serine/threonine-protein kinase MRCK beta
50
194630
6.05
8
5
5
2
5
0.06
0.04

TCOF_MOUSE
Treacle protein
50
134921
9.35
3
2
2
1
2
0.04
0.03

ACOT9_MOUSE
Acyl-coenzyme A thioesterase 9, mitochondrial
50
50528
8.74
8
3
5
2
5
0.23
0.18

RRP1_MOUSE
Ribosomal RNA processing protein 1 homolog A
50
54743
5.04
1
1
1
1
1
0.05
0.08

CHRD1_MOUSE
Cysteine and histidine-rich domain-containing protein 1
50
37327
8.13
4
1
3
1
3
0.18
0.12

HMGCL_MOUSE
Hydroxymethylglutaryl-CoA lyase, mitochondrial
50
34217
8.7
5
2
4
2
4
0.18
0.27

ANFY1_MOUSE
Rabankyrin-5
49
128571
5.58
6
3
6
3
6
0.11
0.1

MOGS_MOUSE
Mannosyl-oligosaccharide glucosidase
49
91774
9.06
7
4
4
3
4
0.1
0.15

SAMH1_MOUSE
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
49
72604
8.17
7
3
6
3
6
0.18
0.19

MPRIP_MOUSE
Myosin phosphatase Rho-interacting protein
49
116337
5.9
6
1
4
1
4
0.07
0.04

G6PD1_MOUSE
Glucose-6-phosphate 1-dehydrogenase X
49
59225
6.06
17
4
9
2
9
0.32
0.15

ATP5I_MOUSE
ATP synthase subunit e, mitochondrial
49
8230
9.34
2
1
1
1
1
0.18
0.63

RL14_MOUSE
60S ribosomal protein L14
49
23549
11.03
4
1
4
1
4
0.23
0.19

FABP4_MOUSE
Fatty acid-binding protein, adipocyte
49
14641
8.53
2
1
2
1
2
0.27
0.32

MCM7_MOUSE
DNA replication licensing factor MCM7
49
81160
5.98
6
2
6
2
6
0.16
0.11

S2611_MOUSE
Sodium-independent sulfate anion transporter
49
64068
7.56
4
3
2
1
2
0.08
0.07

UBQL1_MOUSE
Ubiquilin-1
49
61937
4.86
10
4
4
2
4
0.13
0.14

GSH0_MOUSE
Glutamate–cysteine ligase regulatory subunit
49
30516
5.35
2
1
2
1
2
0.17
0.15

PDK3_MOUSE
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
49
47893
8.89
1
1
1
1
1
0.04
0.09

P3H3_MOUSE
Prolyl 3-hydroxylase 3
48
81650
6.21
7
2
5
1
5
0.14
0.05

ARP10_MOUSE
Actin-related protein 10
48
46178
7.54
4
2
4
2
4
0.2
0.2

ARL2_MOUSE
ADP-ribosylation factor-like protein 2
48
20851
5.67
4
2
1
1
1
0.14
0.22

LAMA5_MOUSE
Laminin subunit alpha-5
48
403792
6.28
6
1
3
1
3
0.02
0.01

IFI5B_MOUSE
Interferon-activable protein 205-B
48
46948
8.2
11
2
8
2
8
0.27
0.19

NXN_MOUSE
Nucleoredoxin
48
48314
4.84
2
1
2
1
2
0.12
0.09

TTC27_MOUSE
Tetratricopeptide repeat protein 27
47
96369
5.56
9
3
4
2
4
0.11
0.09

GPAA1_MOUSE
Glycosylphosphatidylinositol anchor attachment 1 protein
47
67905
8.61
2
1
2
1
2
0.08
0.06

CP062_MOUSE
UPF0505 protein C16orf62 homolog
47
109007
6.97
7
1
5
1
5
0.08
0.04

CNOT1_MOUSE
CCR4-NOT transcription complex subunit 1
47
266637
6.65
8
2
8
2
8
0.07
0.03

NDUS3_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
47
30131
6.67
4
1
3
1
3
0.18
0.15

CGNL1_MOUSE
Cingulin-like protein 1
47
148140
5.6
5
1
5
1
5
0.06
0.03

MCES_MOUSE
mRNA cap guanine-N7 methyltransferase
47
53258
6.12
4
2
3
1
3
0.09
0.08

EXOC7_MOUSE
Exocyst complex component 7
47
79910
6.51
6
2
4
1
4
0.14
0.05

GOGA3_MOUSE
Golgin subfamily A member 3
47
167118
5.29
7
1
7
1
7
0.1
0.03

IR3IP_MOUSE
Immediate early response 3-interacting protein 1
47
9011
7.96
2
1
2
1
2
0.32
0.56

CIP4_MOUSE
Cdc42-interacting protein 4
47
68447
5.66
1
1
1
1
1
0.02
0.06

GALT2_MOUSE
Polypeptide N-acetylgalactosaminyltransferase 2
46
64473
8.8
9
1
6
1
6
0.17
0.07

CD9_MOUSE
CD9 antigen
46
25241
6.88
5
4
2
1
2
0.26
0.18

NOP58_MOUSE
Nucleolar protein 58
46
60305
8.53
4
1
3
1
3
0.11
0.07

NIPS2_MOUSE
Protein NipSnap homolog 2
46
32912
9.31
4
2
2
2
2
0.15
0.29

AMPB_MOUSE
Aminopeptidase B
45
72370
5.22
7
3
6
3
6
0.22
0.19

NB5R1_MOUSE
NADH-cytochrome b5 reductase 1
45
34113
8.97
4
1
3
1
3
0.15
0.13

VPP2_MOUSE
V-type proton ATPase 116 kDa subunit a isoform 2
45
98081
6.2
3
1
2
1
2
0.05
0.04

IMPCT_MOUSE
Protein IMPACT
45
36253
4.97
9
2
4
2
4
0.24
0.26

MARE3_MOUSE
Microtubule-associated protein RP/EB family member 3
45
31946
5.33
2
1
2
1
2
0.17
0.14

TMM43_MOUSE
Transmembrane protein 43
45
44755
6.85
3
2
3
2
3
0.14
0.2

FA98B_MOUSE
Protein FAM98B
45
45321
8.77
4
1
3
1
3
0.19
0.1

ERP44_MOUSE
Endoplasmic reticulum resident protein 44
44
46823
5.09
2
1
2
1
2
0.1
0.09

TSP2_MOUSE
Thrombospondin-2
44
129798
4.61
9
2
6
2
5
0.1
0.07

HEM2_MOUSE
Delta-aminolevulinic acid dehydratase
44
36000
6.32
11
7
3
1
3
0.2
0.12

UROK_MOUSE
Urokinase-type plasminogen activator
44
48236
8.53
5
1
3
1
3
0.17
0.09

IF4G2_MOUSE
Eukaryotic translation initiation factor 4 gamma 2
44
102041
6.7
10
5
7
3
7
0.14
0.13

RSU1_MOUSE
Ras suppressor protein 1
44
31531
8.86
10
2
5
1
5
0.39
0.14

ITB5_MOUSE
Integrin beta-5
44
87851
5.81
8
3
8
3
8
0.22
0.15

SEP10_MOUSE
Septin-10
44
52388
6.17
8
2
5
1
5
0.15
0.08

EMC1_MOUSE
ER membrane protein complex subunit 1
44
111535
7
11
3
7
3
7
0.15
0.12

A16L1_MOUSE
Autophagy-related protein 16-1
43
68130
5.96
6
1
2
1
2
0.06
0.06

MINP1_MOUSE
Multiple inositol polyphosphate phosphatase 1
43
54503
7.21
3
2
2
1
2
0.09
0.08

MTAP_MOUSE
S-Methyl-5-thioadenosine phosphorylase
43
31042
6.71
6
3
3
2
3
0.22
0.31

EMAL2_MOUSE
Echinoderm microtubule-associated protein-like 2
43
70689
5.83
5
2
2
1
2
0.07
0.06

ACADV_MOUSE
Very-long-chain-specific acyl-CoA dehydrogenase, mitochondrial
43
70831
8.91
9
1
6
1
6
0.19
0.06

AOFB_MOUSE
Amine oxidase [flavin-containing] B
43
58520
8.52
7
2
5
2
5
0.16
0.15

NRADD_MOUSE
Death domain-containing membrane protein NRADD
43
24711
4.89
3
3
1
1
1
0.14
0.4

DHSD_MOUSE
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
43
17003
9.3
1
1
1
1
1
0.16
0.27

CSN9_MOUSE
COP9 signalosome complex subunit 9
43
6193
3.6
1
1
1
1
1
0.35
0.89

VP13C_MOUSE
Vacuolar protein sorting-associated protein 13C
43
419824
6.37
8
1
8
1
8
0.05
0.01

EMAL1_MOUSE
Echinoderm microtubule-associated protein-like 1
43
89624
6.56
10
2
8
2
8
0.21
0.1

TIP_MOUSE
T cell immunomodulatory protein
42
67422
5.4
6
1
2
1
2
0.09
0.06

CLU_MOUSE
Clustered mitochondria protein homolog
42
147975
5.69
2
2
2
2
2
0.03
0.06

PSME1_MOUSE
Proteasome activator complex subunit 1
40
28655
5.73
5
3
4
3
4
0.26
0.54

MFGM_MOUSE
Lactadherin
42
51208
6.1
8
3
6
3
6
0.19
0.28

E41L3_MOUSE
Band 4.1-like protein 3
42
103274
5.2
1
1
1
1
1
0.01
0.04

LMAN2_MOUSE
Vesicular integral-membrane protein VIP36
42
40404
6.46
6
2
5
2
5
0.23
0.23

PPM1F_MOUSE
Protein phosphatase 1F
42
49580
5.16
6
3
5
3
5
0.28
0.29

SERC3_MOUSE
Serine incorporator 3
42
52588
6.95
1
1
1
1
1
0.06
0.08

ARHG1_MOUSE
Rho guanine nucleotide exchange factor 1
42
102741
5.43
6
2
6
2
6
0.11
0.08

RS27A_MOUSE
Ubiquitin-40S ribosomal protein S27a
34
17939
9.68
7
2
2
2
2
0.22
0.58

MANEA_MOUSE
Glycoprotein endo-alpha-1,2-mannosidase
42
53149
8.66
1
1
1
1
1
0.03
0.08

MYO1B_MOUSE
Unconventional myosin-Ib
41
128483
9.32
3
1
2
1
2
0.04
0.03

PTCD3_MOUSE
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
41
77747
5.61
4
2
3
1
3
0.08
0.06

COG2_MOUSE
Conserved oligomeric Golgi complex subunit 2
41
81988
5.84
2
1
2
1
2
0.09
0.05

KTN1_MOUSE
Kinectin
41
152498
5.67
7
2
7
2
7
0.1
0.06

ARXS1_MOUSE
Adipocyte-related X-chromosome expressed sequence 1
41
20134
9.6
2
1
2
1
2
0.14
0.23

RAB23_MOUSE
Ras-related protein Rab-23
41
26662
6.36
4
1
4
1
4
0.41
0.17

SMRC1_MOUSE
SWI/SNF complex subunit SMARCC1
41
122813
5.5
5
1
5
1
4
0.08
0.03

HGNAT_MOUSE
Heparan-alpha-glucosaminide N-acetyltransferase
41
72458
8.58
2
2
1
1
1
0.05
0.06

GGCT_MOUSE
Gamma-glutamylcyclotransferase
41
21152
5.52
3
1
3
1
3
0.31
0.21

PLPP1_MOUSE
Phospholipid phosphatase 1
41
31871
6.54
6
3
3
2
3
0.16
0.3

RFOX2_MOUSE
RNA binding protein fox-1 homolog 2
40
47301
6.1
3
1
3
1
3
0.1
0.09

DPP9_MOUSE
Dipeptidyl peptidase 9
40
97939
6.18
3
1
3
1
3
0.03
0.04

CD63_MOUSE
CD63 antigen
40
25749
6.69
3
2
1
1
1
0.05
0.17

ARFG1_MOUSE
ADP-ribosylation factor GTPase-activating protein 1
40
45260
5.39
2
1
2
1
2
0.11
0.1

NOP16_MOUSE
Nucleolar protein 16
40
21126
9.91
1
1
1
1
1
0.1
0.22

SNRPA_MOUSE
U1 small nuclear ribonucleoprotein A
40
31814
9.81
3
1
3
1
3
0.18
0.14

KIF1C_MOUSE
Kinesin-like protein KIF1C
40
122358
6.62
6
1
5
1
5
0.1
0.03

LRC40_MOUSE
Leucine-rich repeat-containing protein 40
40
68033
6.43
3
1
3
1
3
0.1
0.06

MAOM_MOUSE
NAD-dependent malic enzyme, mitochondrial
40
65757
7.53
2
2
2
2
2
0.08
0.14

LAMB1_MOUSE
Laminin subunit beta-1
40
196961
4.82
13
2
6
1
6
0.08
0.02

GTR1_MOUSE
Solute carrier family 2, facilitated glucose transporter member 1
40
53949
9.05
5
3
4
2
4
0.13
0.17

CKAP5_MOUSE
Cytoskeleton-associated protein 5
40
225492
8.17
11
2
9
2
9
0.08
0.04

LYAR_MOUSE
Cell growth-regulating nucleolar protein
40
43708
9.52
4
1
3
1
3
0.1
0.1

SAAL1_MOUSE
Protein SAAL1
40
52735
4.4
4
1
4
1
4
0.2
0.08

WDR12_MOUSE
Ribosome biogenesis protein WDR12
40
47317
5.36
2
1
1
1
1
0.08
0.09

TBC15_MOUSE
TBC1 domain family member 15
39
76478
5.15
2
2
1
1
1
0.04
0.06

PGLT1_MOUSE
Protein O-glucosyltransferase 1
39
46350
9.04
2
2
2
2
2
0.11
0.2

ACOD2_MOUSE
Acyl-CoA desaturase 2
39
40890
9.14
2
1
2
1
2
0.12
0.11

ARHG2_MOUSE
Rho guanine nucleotide exchange factor 2
39
111905
6.89
3
2
2
1
2
0.06
0.04

NFKB2_MOUSE
Nuclear factor NF-kappa-B p100 subunit
39
96772
5.93
4
3
2
2
2
0.06
0.09

NU188_MOUSE
Nucleoporin NUP188 homolog
39
196570
6.56
5
1
4
1
4
0.05
0.02

MCA3_MOUSE
Eukaryotic translation elongation factor 1 epsilon-1
39
19846
8.6
4
2
3
1
3
0.33
0.23

STING_MOUSE
Stimulator of interferon genes protein
39
42802
7.12
6
3
4
2
4
0.23
0.21

5NT3A_MOUSE
Cytosolic 5-nucleotidase 3A
39
37228
6.21
2
1
2
1
2
0.15
0.12

NDUV3_MOUSE
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
39
11806
9.34
3
2
2
1
2
0.32
0.41

MTX1_MOUSE
Metaxin-1
39
35601
5.82
2
2
1
1
1
0.04
0.12

EMC3_MOUSE
ER membrane protein complex subunit 3
39
29960
6.33
4
3
2
1
2
0.16
0.15

TULP3_MOUSE
Tubby-related protein 3
38
51199
5.88
3
1
2
1
2
0.12
0.08

SEC63_MOUSE
Translocation protein SEC63 homolog
38
87815
5.28
8
3
5
3
5
0.09
0.15

TFAM_MOUSE
Transcription factor A, mitochondrial
38
27970
9.71
1
1
1
1
1
0.06
0.16

TMX4_MOUSE
Thioredoxin-related transmembrane protein 4
38
37108
4.3
2
1
1
1
1
0.05
0.12

SP16H_MOUSE
FACT complex subunit SPT16
38
119749
5.5
7
3
4
2
4
0.08
0.07

ACADS_MOUSE
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
38
44861
8.68
2
2
1
1
1
0.08
0.1

HEXB_MOUSE
Beta-hexosaminidase subunit beta
38
61077
8.29
4
2
2
1
2
0.11
0.07

GBP2_MOUSE
Guanylate-binding protein 2
38
66697
5.56
2
2
1
1
1
0.04
0.06

SK2L2_MOUSE
Superkiller viralicidic activity 2-like 2
37
117561
6.01
10
2
8
1
8
0.16
0.04

PFKAP_MOUSE
ATP-dependent 6-phosphofructokinase, platelet type
37
85400
6.73
9
1
8
1
8
0.18
0.05

T2FB_MOUSE
General transcription factor IIF subunit 2
37
28364
9.23
3
1
2
1
2
0.11
0.16

SAM50_MOUSE
Sorting and assembly machinery component 50 homolog
37
51831
6.34
3
1
3
1
3
0.12
0.08

XRCC6_MOUSE
X-ray repair cross-complementing protein 6
37
69441
6.35
1
1
1
1
1
0.03
0.06

KBL_MOUSE
2-Amino-3-ketobutyrate coenzyme A ligase, mitochondrial
37
44902
6.92
1
1
1
1
1
0.06
0.1

PRI2_MOUSE
DNA primase large subunit
37
58372
8.47
3
1
3
1
3
0.13
0.07

TGM2_MOUSE
Protein-glutamine gamma-glutamyltransferase 2
37
77012
4.98
2
2
2
2
2
0.07
0.11

SPART_MOUSE
Spartin
37
72610
5.64
4
1
3
1
3
0.12
0.06

SRRM1_MOUSE
Serine/arginine repetitive matrix protein 1
37
106798
11.87
4
1
2
1
2
0.04
0.04

CSPG4_MOUSE
Chondroitin sulfate proteoglycan 4
37
252153
5.23
8
2
7
2
7
0.07
0.03

DHX29_MOUSE
ATP-dependent RNA helicase DHX29
36
153879
8.13
3
1
3
1
3
0.03
0.03

DECR_MOUSE
2,4-Dienoyl-CoA reductase, mitochondrial
36
36191
9.1
6
2
5
1
5
0.22
0.12

CHKB_MOUSE
Choline/ethanolamine kinase
36
45097
5.3
3
1
2
1
2
0.12
0.1

RLA1_MOUSE
60S acidic ribosomal protein P1
36
11468
4.28
2
2
1
1
1
0.14
0.43

MBD3_MOUSE
Methyl-CpG-binding domain protein 3
36
32148
5.64
3
1
2
1
2
0.11
0.14

IF6_MOUSE
Eukaryotic translation initiation factor 6
36
26494
4.63
2
1
2
1
2
0.26
0.17

NISCH_MOUSE
Nischarin
36
174903
5.05
3
2
3
2
3
0.04
0.05

CD44_MOUSE
CD44 antigen
36
85565
4.82
4
3
2
2
2
0.05
0.1

NPM3_MOUSE
Nucleoplasmin-3
36
19011
4.71
1
1
1
1
1
0.19
0.24

SNX2_MOUSE
Sorting nexin-2
35
58435
5.04
2
1
2
1
2
0.1
0.07

MRP1_MOUSE
Multidrug resistance-associated protein 1
35
171075
7.03
5
1
5
1
5
0.07
0.02

SERB_MOUSE
Phosphoserine phosphatase
35
25080
5.81
4
2
3
2
3
0.24
0.39

SMYD5_MOUSE
SET and MYND domain-containing protein 5
35
47065
5.09
2
1
1
1
1
0.06
0.09

PGFRB_MOUSE
Platelet-derived growth factor receptor beta
35
122728
4.99
8
2
6
2
6
0.09
0.07

APAF_MOUSE
Apoptotic protease-activating factor 1
35
140913
5.98
6
1
3
1
3
0.04
0.03

PLS3_MOUSE
Phospholipid scramblase 3
35
31782
5.97
6
2
3
2
3
0.11
0.3

NMRL1_MOUSE
NmrA-like family domain-containing protein 1
35
34355
6.37
3
1
2
1
2
0.15
0.13

EHD2_MOUSE
EH domain-containing protein 2
35
61136
6.08
10
3
6
3
6
0.21
0.23

CRKL_MOUSE
Crk-like protein
34
33809
6.26
9
2
4
1
4
0.23
0.13

EI2BB_MOUSE
Translation initiation factor eIF-2B subunit beta
34
38873
5.82
4
2
3
1
3
0.22
0.11

BLVRB_MOUSE
Flavin reductase (NADPH)
34
22183
6.49
7
1
4
1
4
0.38
0.2

SRSF6_MOUSE
Serine/arginine-rich splicing factor 6
34
39002
11.46
2
1
1
1
1
0.07
0.11

TRI47_MOUSE
Tripartite motif-containing protein 47
34
69868
6
2
2
1
1
1
0.05
0.06

ICLN_MOUSE
Methylosome subunit pICln
34
26005
3.98
2
1
2
1
2
0.15
0.17

GNS_MOUSE
N-Acetylglucosamine-6-sulfatase
34
61136
8.52
16
2
9
2
9
0.35
0.15

PLBL2_MOUSE
Putative phospholipase B-like 2
34
66247
5.77
5
1
4
1
4
0.12
0.07

TBCA_MOUSE
Tubulin-specific chaperone A
34
12750
5.24
3
1
2
1
2
0.37
0.38

SGPL1_MOUSE
Sphingosine-1-phosphate lyase 1
34
63636
9.2
6
1
5
1
5
0.11
0.07

T126A_MOUSE
Transmembrane protein 126A
34
21526
9.45
2
1
2
1
2
0.17
0.21

DHR11_MOUSE
Dehydrogenase/reductase SDR family member 11
34
28256
5.91
3
2
2
1
2
0.17
0.16

KTAP2_MOUSE
Keratinocyte-associated protein 2
34
14665
9.67
3
1
1
1
1
0.2
0.32

LAMC1_MOUSE
Laminin subunit gamma-1
33
177185
5.08
3
1
3
1
3
0.04
0.02

3HIDH_MOUSE
3-Hydroxyisobutyrate dehydrogenase, mitochondrial
33
35417
8.37
3
1
2
1
2
0.19
0.12

BGAL_MOUSE
Beta-galactosidase
33
73074
7.15
2
1
2
1
2
0.06
0.06

FKBP8_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP8
33
43501
5.08
2
1
2
1
2
0.11
0.1

CASP3_MOUSE
Caspase-3
33
31454
6.45
4
1
3
1
3
0.24
0.14

RT33_MOUSE
28S ribosomal protein S33, mitochondrial
33
12452
10.25
1
1
1
1
1
0.2
0.39

ATX2L_MOUSE
Ataxin-2-like protein
33
110580
8.94
3
1
3
1
3
0.07
0.04

SELB_MOUSE
Selenocysteine-specific elongation factor
33
63498
8.58
2
1
2
1
2
0.09
0.07

TRI16_MOUSE
Tripartite motif-containing protein 16
33
62903
5.57
2
1
2
1
2
0.06
0.07

ARSA_MOUSE
Arylsulfatase A
33
53714
5.5
3
1
2
1
2
0.1
0.08

BL1S6_MOUSE
Biogenesis of lysosome-related organelles complex 1 subunit 6
33
19670
5.91
2
1
1
1
1
0.11
0.23

ECH1_MOUSE
Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial
33
36095
7.6
4
1
4
1
4
0.31
0.12

DIAP3_MOUSE
Protein diaphanous homolog 3
32
133601
7.53
3
1
3
1
3
0.05
0.03

ERG1_MOUSE
Squalene monooxygenase
32
63730
8.67
5
1
2
1
2
0.1
0.07

DDX46_MOUSE
Probable ATP-dependent RNA helicase DDX46
32
117376
9.3
4
1
3
1
3
0.05
0.04

M4K4_MOUSE
Mitogen-activated protein kinase 4
32
140515
7.1
7
1
7
1
7
0.1
0.03

ABCD3_MOUSE
ATP-binding cassette sub-family D member 3
32
75426
9.32
9
1
7
1
7
0.13
0.06

PSMG1_MOUSE
Proteasome assembly chaperone 1
32
33083
6.05
4
2
2
1
2
0.12
0.29

FRDA_MOUSE
Frataxin, mitochondrial
32
22910
7.81
1
1
1
1
1
0.08
0.2

THOP1_MOUSE
Thimet oligopeptidase
32
77976
5.72
3
2
2
1
2
0.06
0.06

CREL2_MOUSE
Cysteine-rich with EGF-like domain protein 2
32
38194
4.49
3
1
2
1
2
0.05
0.11

SSRD_MOUSE
Translocon-associated protein subunit delta
32
18924
5.5
4
1
4
1
4
0.31
0.24

I2BP2_MOUSE
Interferon regulatory factor 2-binding protein 2
32
59255
9
6
1
5
1
5
0.18
0.07

RL29_MOUSE
60S ribosomal protein L29
31
17576
11.84
2
1
2
1
2
0.17
0.26

B4GT1_MOUSE
Beta-1,4-galactosyltransferase 1
31
44383
9.45
3
1
2
1
2
0.07
0.1

HTR5A_MOUSE
HEAT repeat-containing protein 5A
31
219754
6.31
6
1
5
1
5
0.06
0.02

SYFB_MOUSE
Phenylalanine–tRNA ligase beta subunit
31
65655
6.69
4
2
3
1
3
0.09
0.07

BAG5_MOUSE
BAG family molecular chaperone regulator 5
31
50911
5.75
3
1
3
1
3
0.14
0.09

HSPB8_MOUSE
Heat shock protein beta-8
31
21520
4.92
1
1
1
1
1
0.13
0.21

SNX7_MOUSE
Sorting nexin-7
31
44971
4.99
4
2
2
2
2
0.12
0.2

TMTC3_MOUSE
Transmembrane and TPR repeat-containing protein 3
31
104131
8.75
5
2
4
1
4
0.06
0.04

NNMT_MOUSE
Nicotinamide N-methyltransferase
31
29579
5.3
4
3
2
2
2
0.16
0.32

WIPI1_MOUSE
WD repeat domain phosphoinositide-interacting protein 1
30
48727
6.03
3
2
2
1
2
0.13
0.09

K1468_MOUSE
LisH domain and HEAT repeat-containing protein KIAA1468
30
134502
5.2
7
1
5
1
5
0.09
0.03

FKBP3_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP3
30
25132
9.29
6
2
6
2
6
0.42
0.39

FHL2_MOUSE
Four and a half LIM domains protein 2
30
32051
7.31
2
1
2
1
2
0.15
0.14

ARI4B_MOUSE
AT-rich interactive domain-containing protein 4B
30
147553
4.98
4
1
3
1
3
0.03
0.03

ANX11_MOUSE
Annexin A11
29
54045
7.53
2
1
1
1
1
0.05
0.08

RM48_MOUSE
39S ribosomal protein L48, mitochondrial
29
23938
9.45
3
1
1
1
1
0.13
0.19

SEN34_MOUSE
tRNA-splicing endonuclease subunit Sen34
29
34176
6.56
2
1
2
1
2
0.13
0.13

HP1B3_MOUSE
Heterochromatin protein 1-binding protein 3
29
60829
9.71
5
2
4
2
4
0.16
0.15

COX8A_MOUSE
Cytochrome c oxidase subunit 8A, mitochondrial
29
7643
9.74
3
1
1
1
1
0.49
0.69

LSM7_MOUSE
U6 snRNA-associated Sm-like protein LSm7
29
11629
5.1
4
2
1
1
1
0.24
0.42

CND1_MOUSE
Condensin complex subunit 1
29
155567
5.98
2
1
2
1
2
0.03
0.03

ARSB_MOUSE
Arylsulfatase B
29
59609
6.78
2
1
1
1
1
0.05
0.07

RBP2_MOUSE
E3 SUMO-protein ligase RanBP2
29
340907
5.82
7
1
7
1
7
0.04
0.01

SRPK1_MOUSE
SRSF protein kinase 1
29
73043
5.82
2
1
1
1
1
0.02
0.06

VAC14_MOUSE
Protein VAC14 homolog
29
87992
5.75
3
2
2
1
2
0.05
0.05

UBR2_MOUSE
E3 ubiquitin-protein ligase UBR2
29
199026
5.9
8
1
5
1
5
0.06
0.02

NCEH1_MOUSE
Neutral cholesterol ester hydrolase 1
29
45711
6.56
3
1
1
1
1
0.07
0.1

LMAN1_MOUSE
Protein ERGIC-53
29
57753
5.92
7
2
5
2
5
0.21
0.16

DREB_MOUSE
Drebrin
29
77239
4.45
2
1
2
1
2
0.06
0.06

AURKB_MOUSE
Aurora kinase B
29
39360
9.47
1
1
1
1
1
0.05
0.11

STOM_MOUSE
Erythrocyte band 7 integral membrane protein
29
31355
6.45
2
1
2
1
2
0.17
0.14

SETD3_MOUSE
Histone-lysine N-methyltransferase setd3
29
67134
5.47
4
2
2
2
2
0.08
0.13

DAAM1_MOUSE
Disheveled-associated activator of morphogenesis 1
29
123293
7.12
6
1
5
1
5
0.08
0.03

IF2B2_MOUSE
Insulin-like growth factor 2 mRNA-binding protein 2
28
65543
7.81
5
1
4
1
4
0.1
0.07

GSDMD_MOUSE
Gasdermin-D
28
53204
5.03
4
2
3
2
3
0.17
0.17

ACON_MOUSE
Aconitate hydratase, mitochondrial
28
85410
8.08
8
2
5
2
5
0.12
0.1

IF4B_MOUSE
Eukaryotic translation initiation factor 4B
28
68799
5.47
3
1
2
1
2
0.09
0.06

XRCC5_MOUSE
X-ray repair cross-complementing protein 5
28
83004
5.04
5
1
5
1
5
0.16
0.05

GALE_MOUSE
UDP-glucose 4-epimerase
28
38200
6.27
5
2
2
1
2
0.14
0.11

SYMPK_MOUSE
Symplekin
28
142194
5.76
11
1
6
1
6
0.07
0.03

NAA10_MOUSE
N-Alpha-acetyltransferase 10
28
26503
5.41
8
3
3
1
3
0.28
0.37

GALD1_MOUSE
Glutamine amidotransferase-like class 1 domain-containing protein 1
28
23263
6.58
1
1
1
1
1
0.09
0.19

ZO1_MOUSE
Tight junction protein ZO-1
28
194622
6.17
6
1
6
1
6
0.07
0.02

PIGS_MOUSE
GPI transamidase component PIG-S
27
61671
6.45
5
2
3
1
3
0.13
0.07

NRP1_MOUSE
Neuropilin-1
27
102935
5.6
3
1
3
1
3
0.07
0.04

LEMD2_MOUSE
LEM domain-containing protein 2
27
57471
9.18
1
1
1
1
1
0.05
0.08

RTCA_MOUSE
RNA 3-terminal phosphate cyclase
27
39229
8.06
4
1
2
1
2
0.13
0.11

SULF1_MOUSE
Extracellular sulfatase Sulf-1
27
100858
9.17
4
1
3
1
3
0.04
0.04

UFC1_MOUSE
Ubiquitin-fold modifier-conjugating enzyme 1
27
19469
6.9
5
1
3
1
3
0.28
0.24

IMPA3_MOUSE
Inositol monophosphatase 3
27
38592
6.03
2
1
2
1
2
0.14
0.11

RINT1_MOUSE
RAD50-interacting protein 1
27
90036
5.02
5
1
4
1
4
0.06
0.05

KCY_MOUSE
UMP-CMP kinase
26
22151
5.68
4
1
4
1
4
0.28
0.2

TRIP6_MOUSE
Thyroid receptor-interacting protein 6
26
50901
7.03
4
1
2
1
2
0.09
0.09

PLXB2_MOUSE
Plexin-B2
26
206099
5.58
7
1
6
1
6
0.07
0.02

UFL1_MOUSE
E3 UFM1-protein ligase 1
26
89464
6.24
4
1
3
1
3
0.1
0.05

SMRC2_MOUSE
SWI/SNF complex subunit SMARCC2
26
132522
5.41
4
1
4
1
3
0.07
0.03

PPOX_MOUSE
Protoporphyrinogen oxidase
26
50839
9.07
1
1
1
1
1
0.06
0.09

PDLI7_MOUSE
PDZ and LIM domain protein 7
26
50087
8.82
1
1
1
1
1
0.07
0.09

CLN3_MOUSE
Battenin
26
47627
5.25
1
1
1
1
1
0.05
0.09

TRM61_MOUSE
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
26
31619
6.3
1
1
1
1
1
0.07
0.14

TBRG4_MOUSE
Protein TBRG4
26
71468
8.55
2
1
2
1
2
0.04
0.06

AN13A_MOUSE
Ankyrin repeat domain-containing protein 13A
26
67136
4.99
1
1
1
1
1
0.03
0.06

TMED3_MOUSE
Transmembrane emp24 domain-containing protein 3
26
25449
5.62
2
1
2
1
2
0.16
0.18

NPL4_MOUSE
Nuclear protein localization protein 4 homolog
26
67974
6.01
4
1
4
1
4
0.13
0.06

SAP18_MOUSE
Histone deacetylase complex subunit SAP18
26
17584
9.38
2
1
2
1
2
0.24
0.26

SUMF2_MOUSE
Sulfatase-modifying factor 2
26
34715
6.61
1
1
1
1
1
0.06
0.13

SYMC_MOUSE
Methionine–tRNA ligase, cytoplasmic
25
101366
6.78
10
1
8
1
8
0.15
0.04

NOL6_MOUSE
Nucleolar protein 6
25
129146
6.33
3
1
3
1
3
0.07
0.03

CRIP2_MOUSE
Cysteine-rich protein 2
25
22712
8.94
4
1
4
1
4
0.39
0.2

GSKIP_MOUSE
GSK3B-interacting protein
25
15632
4.3
3
1
1
1
1
0.17
0.3

STAR5_MOUSE
StAR-related lipid transfer protein 5
25
23907
5.97
3
1
3
1
3
0.18
0.19

LARP4_MOUSE
La-related protein 4
25
79713
6.02
2
1
2
1
2
0.06
0.05

OFUT1_MOUSE
GDP-fucose protein O-fucosyltransferase 1
25
44660
8.67
1
1
1
1
1
0.05
0.1

RHG10_MOUSE
Rho GTPase-activating protein 10
25
89309
6.75
6
1
4
1
4
0.1
0.05

SRA1_MOUSE
Steroid receptor RNA activator 1
25
25541
6.01
2
1
2
1
2
0.17
0.18

COR1B_MOUSE
Coronin-1B
25
53878
5.54
9
1
6
1
6
0.18
0.08

NIF3L_MOUSE
NIF3-like protein 1
25
41719
6.28
4
2
1
1
1
0.05
0.1

LYOX_MOUSE
Protein-lysine 6-oxidase
25
46671
8.73
3
1
1
1
1
0.08
0.09

GSH1_MOUSE
Glutamate–cysteine ligase catalytic subunit
25
72525
5.59
8
2
3
1
3
0.09
0.06

GIT2_MOUSE
ARF GTPase-activating protein GIT2
25
78717
7.64
5
1
5
1
5
0.12
0.05

BL1S2_MOUSE
Biogenesis of lysosome-related organelles complex 1 subunit 2
24
16289
4.82
3
2
1
1
1
0.19
0.29

IBP7_MOUSE
Insulin-like growth factor-binding protein 7
24
28951
8.71
1
1
1
1
1
0.07
0.15

PLIN3_MOUSE
Perilipin-3
24
47233
5.45
8
2
4
2
4
0.24
0.19

TM9S2_MOUSE
Transmembrane 9 superfamily member 2
24
75280
7.21
5
2
2
1
2
0.09
0.06

CAP2_MOUSE
Adenylyl cyclase-associated protein 2
24
52829
6
3
1
2
1
2
0.06
0.08

LPP_MOUSE
Lipoma-preferred partner homolog
24
65848
7.19
7
1
5
1
5
0.17
0.07

STXB3_MOUSE
Syntaxin-binding protein 3
24
67899
8.28
5
1
3
1
3
0.12
0.06

EDC4_MOUSE
Enhancer of mRNA-decapping protein 4
23
152389
5.51
5
1
4
1
4
0.06
0.03

CO6A2_MOUSE
Collagen alpha-2(VI) chain
23
110266
6.01
2
1
2
1
2
0.04
0.04

ATG4B_MOUSE
Cysteine protease ATG4B
23
44347
4.93
1
1
1
1
1
0.04
0.1

GGPPS_MOUSE
Geranylgeranyl pyrophosphate synthase
23
34685
6.03
2
1
1
1
1
0.09
0.13

TT39B_MOUSE
Tetratricopeptide repeat protein 39B
23
70248
6.22
3
1
2
1
2
0.06
0.06

VPS11_MOUSE
Vacuolar protein sorting-associated protein 11 homolog
22
107650
6.54
3
1
2
1
2
0.05
0.04

KANK2_MOUSE
KN motif and ankyrin repeat domain-containing protein 2
22
90190
5.38
2
1
2
1
2
0.06
0.05

ANO6_MOUSE
Anoctamin-6
22
106186
6.34
2
1
1
1
1
0.01
0.04

ACAD8_MOUSE
Isobutyryl-CoA dehydrogenase, mitochondrial
22
44990
8.46
1
1
1
1
1
0.06
0.1

BASI_MOUSE
Basigin
22
42418
5.56
3
1
1
1
1
0.04
0.1

RO60_MOUSE
60 kDa SS-A/Ro ribonucleoprotein
22
60085
8.11
4
1
3
1
3
0.09
0.07

AHSA2_MOUSE
Activator of 90 kDa heat shock protein ATPase homolog 2
22
37624
6.1
2
1
2
1
2
0.11
0.12

CND2_MOUSE
Condensin complex subunit 2
21
82251
4.81
2
1
2
1
2
0.05
0.05

TM214_MOUSE
Transmembrane protein 214
21
76381
9.41
3
1
2
1
2
0.06
0.06

MPC1_MOUSE
Mitochondrial pyruvate carrier 1
21
12446
9.67
3
1
1
1
1
0.19
0.39

PIGT_MOUSE
GPI transamidase component PIG-T
21
65663
8.68
1
1
1
1
1
0.03
0.07

UBP4_MOUSE
Ubiquitin carboxyl-terminal hydrolase 4
21
108274
5.42
6
2
3
1
3
0.09
0.04

DNLI1_MOUSE
DNA ligase 1
21
102226
6.43
1
1
1
1
1
0.02
0.04

FUCO_MOUSE
Tissue alpha-L-fucosidase
20
52247
6.47
1
1
1
1
1
0.04
0.08

CEBPZ_MOUSE
CCAAT/enhancer-binding protein zeta
20
120187
5.53
5
1
3
1
3
0.08
0.04

E2AK2_MOUSE
Interferon-induced, double-stranded RNA-activated protein kinase
20
58243
8.76
4
1
3
1
3
0.12
0.07

AFG31_MOUSE
AFG3-like protein 1
20
86992
9
1
1
1
1
1
0.02
0.05

RICTR_MOUSE
Rapamycin-insensitive companion of mTOR
20
191449
6.8
9
1
5
1
5
0.05
0.02

NOC4L_MOUSE
Nucleolar complex protein 4 homolog
19
58638
6.29
3
1
1
1
1
0.04
0.07

SOAT1_MOUSE
Sterol O-acyltransferase 1
19
63757
9.15
6
1
4
1
4
0.15
0.07

SH3G1_MOUSE
Endophilin-A2
19
41492
5.53
2
1
1
1
1
0.04
0.11

ILVBL_MOUSE
Acetolactate synthase-like protein
19
68113
8.96
2
1
2
1
2
0.09
0.06

LASP1_MOUSE
LIM and SH3 domain protein 1
19
29975
6.61
6
1
5
1
5
0.19
0.15

NUMA1_MOUSE
Nuclear mitotic apparatus protein 1
18
235487
5.68
10
1
10
1
10
0.08
0.02

DPP8_MOUSE
Dipeptidyl peptidase 8
18
102121
5.51
3
1
2
1
2
0.04
0.04

MTX2_MOUSE
Metaxin-2
18
29739
5.44
1
1
1
1
1
0.11
0.15

RM15_MOUSE
39S ribosomal protein L15, mitochondrial
18
33521
10.08
2
1
2
1
2
0.1
0.13

PM34_MOUSE
Peroxisomal membrane protein PMP34
17
34391
10.11
1
1
1
1
1
0.07
0.13

PPP5_MOUSE
Serine/threonine-protein phosphatase 5
17
56840
5.83
4
1
4
1
4
0.17
0.08

DOK1_MOUSE
Docking protein 1
16
52419
6.16
4
1
3
1
3
0.14
0.08

LEG9_MOUSE
Galectin-9
16
40010
9.41
3
1
1
1
1
0.06
0.11

PGM2_MOUSE
Phosphoglucomutase-2
16
68704
5.78
2
1
2
1
2
0.08
0.06

HSP7E_MOUSE
Heat shock 70 kDa protein 14
16
54616
5.63
4
1
4
1
4
0.17
0.08

PUM2_MOUSE
Pumilio homolog 2
15
114243
6.61
3
1
3
1
3
0.08
0.04

aProtein score is calculated from the score of the peptide attributed to the protein. bpI is (predicted) isoelectric point. cNumber of matches is spectrum number matched to protein#1. dNumber of significant matches is spectrum number that matches protein and exceeds the identification criteria. eNumber of sequences is number of peptides matched to protein#2. fNumber of significant sequences is number of peptides exceeding the identification criteria matched to proteins. gNumber of unique sequences is a unique#3 number of peptides matched to proteins. hSequence coverage is the ratio of the total number of matched peptide residues to the total length of the protein. iExponentially modified protein abundance index (http://www.matrixscience.com/help/quant_empai_help.html). #1When multiple spectra are matched to the same peptide, the way of counting into one is called "peptide number". #2When multiple spectra are matched to the same peptide, the method of counting is called "spectrum number". #3"Unique" is a peptide that is not matched to other proteins and has been assigned only to the relevant protein.

Figure 2: Venn diagram of proteins detected on LC-MS/MS. There were 1785 types of proteins identified from the mouse primary cultured cell (P0) sample and 1825 types of proteins identified from samples of cells passaged 3 times (P3). Among the 1785 types of proteins in mouse P0 cells, there were 336 types of proteins unique to the primary cultured cells (group P0). A total of 1449 types of proteins in mouse P0 cells were also identified in mouse P3 cells (group P0&P3). Among the 1825 types of proteins in mouse P3 cells, there were 376 types of proteins unique to the cells passaged 3 times (group P3).

The amount of protein quantified in this paper is a theoretical value estimated based on the emPAI function of the Scaffold software program. The ratio of the number of measured peptides to the number of theoretical peptides is linearly related to the logarithm of the protein concentration, and the number obtained by subtracting 1 from the index of the peptide number ratio was defined as the emPAI. The larger the emPAI value, the greater the amount of protein. We recently published a paper on the correlation between different emPAI values (>0, >1, >2, >3, >5, and >10) and the results of protein expression analyses. The results showed that, for an emPAI value > 10, the presence of protein can be detected with a high probability, even if the number of samples is [25]. Proteins quantified using emPAI were listed from the top in the tables showing the GO analysis results (Tables 1 and 2) in descending order of concentration. Since the data of this study were derived from a single protein expression analysis obtained from mMSC-ATs of three mice, the data reliability must be carefully considered.

3.4. The Biological Processes, Cellular Components, and Molecular Function of Proteins Identified from mMSC-ATs (P0)

The biological processes of proteins were analyzed using the Mascot software program with the SwissProt 2017 database.

3.4.1. Biological Processes

Antiviral protein was detected as a protein component of mMSC-ATs (P0) (rich in components of SVF). Isg15, Npc2, Ripk3, Fmr1, Dag1, Vps16, Gas6, Stmn1, Vapb, Tri25, Eea1, Asc, Ifm2, Bst2, Apoe, Ltor5, Oas1a, and Nect2 were detected as factors related to the viral process (Figure 3).

Figure 3: The biological processes, cellular components, and molecular function of the mouse primary cultured cell (P0) proteins (as determined by GO). The PCA of proteome dynamics based on the protein information generated by high-resolution mass spectrometry. The ordinate indicates the biological function, cellular component, and molecular function of the protein. The abscissa indicates the number of identified proteins. The names of the proteins classified in Table 3 are listed by their detailed molecular functions.

Stml2 (CD4-positive, alpha-beta T cell activation), CD36, CD180 (B cell proliferation), CD47 (opsonization), and CD166 (adaptive immune response) were detected as factors related to the CD cell surface markers related to the immune system. Cats, Ha1b, Erap1, Mdr1a, Psb8, and Ha11 were detected as factors related to the MHC class antigen and thereby related to the immune system. Csf1 (osteoclast differentiation), CD109 (osteoclast fusion), and Rab35 (antigen processing and presentation) were detected as factors related to the bone immune system. Isg15, Tri25, Ifm2, Bst2, Oas1a, and Asc were detected as factors related to the antiviral immune system. Tgbr3, Plek (hematopoietic progenitor cell differentiation), Ripk3 (T cell differentiation in thymus), Gas6 (macrophage cytokine production), Sfxn1 (erythrocyte differentiation), Ada (T cell activation, B cell differentiation), Itam (activated T cell proliferation), Pfd1 (B cell activation), Sbds (leukocyte chemotaxis), Aimp1 (leukocyte migration), Armc6 (hematopoietic progenitor cell differentiation), Glrx5 (hemopoiesis), Hdac7 (B cell activation, B cell differentiation), Psn1 (T cell activation), Ada10 (monocyte activation), and Tpd52 (B cell differentiation) were detected as factors related to hematopoiesis. A4, Ada15, Ptms (immune system process), Fcgrn (antigen processing and presentation), Il4ra, Ilf2, Ic1 (complement activation), Olr1, and Snp23 (histamine secretion by mast cell) were detected as factors related to the immune response. Stat1 was detected as an interferon-related immune response factor. Those proteins were detected as factors related to the immune system process (Figure 3).

Csf1 (mammary duct terminal end bud growth), Tgbr3 (cardiac muscle cell proliferation), A4 (synaptic growth at neuromuscular junction), Ada15 (tissue regeneration), CD166 (axon extension involved in axon guidance, neuron projection extension), Tbl1r (multicellular organism growth), Ninj1 (tissue regeneration), and Sbds (inner cell mass cell proliferation) were detected as factors related to growth in biological processes (Figure 3).

3.4.2. Cellular Components

Stml2 (T cell receptor complex), Stx7 (immunological synapse), Ha1b (MHC class I protein complex), Ha11 (MHC class I protein complex), CD166 (T cell receptor complex), At2b1 (apical plasma membrane), Gna11 (heterotrimeric G-protein complex), Home3 (postsynaptic membrane), Ampn, Rdh11, Nsf1c, Bag3, Csf1, Vatc1, Necp2, CD109, CD36, Ece1, Tgbr3, A4, Ripk3, Gdn, Erln2, Aaat, Suca, Snp23, Prio, Ly6a, Plp2, Plek, Tpbg, Fmr1, Plin4, Ldlr, Pdc10, Dag1, Rap2a, Vatg1, Pp2ba, Rab35, Il1ap, Eea1, Fcgrn, Ada, Cdv3, Erap1, Ifm2, Bst2, CD180, Il4ra, Itam, Osmr, P2rx4, Serc1, Tradd, CD97, Rab4b, Rab8a, Sucb2, Apoe, Bap31, Cdipt, Cn37, Crk, Dnjb4, Ggt5, Mdr1a, Piez1, Praf1, Psn1, S39ae, Stx2, Tnr12, Vmp1, Fen1, CD47, Olr1, Pygl, Wwox, Ctl1, Ly6c1, Nect2, and Ttyh2 (plasma membrane) were detected as factors related to growth in the plasma membrane of the cellular component (Figure 3).

3.4.3. Molecular Functions

SRXN1 (antioxidant activity), TXD17 (peroxidase activity), PGFS (thioredoxin peroxidase activity), and APOE (antioxidant activity) are proteins that are expressed on the plasma membrane. These proteins have been reported to be factors related to both growth and the antioxidant activity according to a classification of the molecular functions (Figure 3). The proteins of mMSC-ATs (P0) are listed in Table 3 with their molecular functions described in detail.

Table 3: Identification of endogenous proteins contained in mMSC-AT_P0 only, not in mMSC-AT_P3.

Exclusive P0 group

UniProt/Swiss-Prot ID
Description
Molecular function

FABP5_MOUSE
Fatty acid-binding protein, epidermal
Fatty acid binding, transporter activity

AMPN_MOUSE
Aminopeptidase N
Metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptide binding, zinc ion binding

AOFA_MOUSE
Amine oxidase [flavin-containing] A
Oxidoreductase activity, primary amine oxidase activity, protein binding

HXK3_MOUSE
Hexokinase-3
ATP binding, fructokinase activity, glucokinase activity, glucose binding, kinase activity, mannokinase activity, nucleotide binding

CTGF_MOUSE
Connective tissue growth factor
Fibronectin binding, growth factor activity, heparin binding, insulin-like growth factor binding, integrin binding, protein C-terminus binding

THIL_MOUSE
Acetyl-CoA acetyltransferase, mitochondrial
Acetyl-CoA C-acetyltransferase activity, carbon-carbon lyase activity, coenzyme binding, enzyme binding, ligase activity, forming carbon-carbon bonds, metal ion binding, protein homodimerization activity, transferase activity, transferring acyl groups

ATPD_MOUSE
ATP synthase subunit delta, mitochondrial
ATPase activity, hydrogen ion transmembrane transporter activity, proton-transporting ATP synthase activity, rotational mechanism

CATS_MOUSE
Cathepsin S
Collagen binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, fibronectin binding, hydrolase activity, laminin binding, proteoglycan binding

CYR61_MOUSE
Protein CYR61
Extracellular matrix binding, growth factor binding, heparin binding, insulin-like growth factor binding, integrin binding

ETFB_MOUSE
Electron transfer flavoprotein subunit beta
Electron carrier activity

SFXN3_MOUSE
Sideroflexin-3
Ion transmembrane transporter activity, molecular function

STML2_MOUSE
Stomatin-like protein 2, mitochondrial
GTPase binding, cardiolipin binding, lipid binding

RDH11_MOUSE
Retinol dehydrogenase 11
NADP-retinol dehydrogenase activity, retinol dehydrogenase activity

NSF1C_MOUSE
NSFL1 cofactor p47
ATPase binding, lipid binding, phospholipid binding, ubiquitin binding

BAG3_MOUSE
BAG family molecular chaperone regulator 3
Adenyl-nucleotide exchange factor activity, cadherin binding involved in cell-cell adhesion, chaperone binding, protein complex binding

CSF1_MOUSE
Macrophage colony-stimulating factor 1
Cytokine activity, growth factor activity, macrophage colony-stimulating factor receptor binding, protein homodimerization activity

LYZ2_MOUSE
Lysozyme C-2
Hydrolase activity, identical protein binding, lysozyme activity

VATC1_MOUSE
V-type proton ATPase subunit C 1
Hydrogen-exporting ATPase activity, phosphorylative mechanism

UBP2L_MOUSE
Ubiquitin-associated protein 2-like
RNA binding

RL28_MOUSE
60S ribosomal protein L28
RNA binding, structural constituent of ribosome

ACSL4_MOUSE
Long-chain-fatty-acid–CoA ligase 4
ATP binding, arachidonate-CoA ligase activity, decanoate–CoA ligase activity, ligase activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very-long-chain fatty acid-CoA ligase activity

THIKA_MOUSE
3-Ketoacyl-CoA thiolase A, peroxisomal
Acetate CoA-transferase activity, acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, palmitoyl-CoA oxidase activity

FA49B_MOUSE
Protein FAM49B
Protein binding

CO5A2_MOUSE
Collagen alpha-2(V) chain
SMAD binding, extracellular matrix structural constituent, metal ion binding

DCTN2_MOUSE
Dynactin subunit 2
Motor activity, spectrin binding

SUCB1_MOUSE
Succinate–CoA ligase [ADP-forming] subunit beta, mitochondrial
ATP binding, ligase activity, metal ion binding, nucleotide binding, succinate-CoA ligase (ADP-forming) activity

SYUG_MOUSE
Gamma-synuclein
Protein binding

GUAD_MOUSE
Guanine deaminase
Guanine deaminase activity, hydrolase activity, metal ion binding, zinc ion binding

ISG15_MOUSE
Ubiquitin-like protein ISG15
Protein binding, protein tag

STK24_MOUSE
Serine/threonine-protein kinase 24
ATP binding, cadherin binding involved in cell-cell adhesion, metal ion binding, nucleotide binding, signal transducer, downstream of receptor, with serine/threonine kinase activity, transferase activity

STX7_MOUSE
Syntaxin-7
SNAP receptor activity, chloride channel inhibitor activity, syntaxin binding

EFHD2_MOUSE
EF-hand domain-containing protein D2
Cadherin binding involved in cell-cell adhesion, calcium ion binding, metal ion binding

NECP2_MOUSE
Adaptin ear-binding coat-associated protein 2
Molecular function

ATP5J_MOUSE
ATP synthase-coupling factor 6, mitochondrial
ATPase activity, hydrogen ion transmembrane transporter activity

ERH_MOUSE
Enhancer of rudimentary homolog
RNA binding, methyl-CpG binding

HAP28_MOUSE
28 kDa heat- and acid-stable phosphoprotein
RNA binding, platelet-derived growth factor binding

TOM20_MOUSE
Mitochondrial import receptor subunit TOM20 homolog
P-P-bond-hydrolysis-driven protein transmembrane transporter activity, mitochondrion targeting sequence binding, protein channel activity, unfolded protein binding

CD109_MOUSE
CD109 antigen
Serine-type endopeptidase inhibitor activity, transforming growth factor beta binding

CD36_MOUSE
Platelet glycoprotein 4
High-density lipoprotein particle binding, lipid binding, lipoteichoic acid receptor activity, low-density lipoprotein particle binding, low-density lipoprotein receptor activity, protein binding

ECE1_MOUSE
Endothelin-converting enzyme 1
Metal ion binding, metalloendopeptidase activity, metallopeptidase activity, protein homodimerization activity

STX12_MOUSE
Syntaxin-12
SNAP receptor activity, SNARE binding, protein binding

TOM1_MOUSE
Target of Myb protein 1
Clathrin binding

CO3A1_MOUSE
Collagen alpha-1(III) chain
SMAD binding, extracellular matrix structural constituent, integrin binding, metal ion binding, platelet-derived growth factor binding

NPC2_MOUSE
Epididymal secretory protein E1
Cholesterol binding, enzyme binding

HA1B_MOUSE
H-2 class I histocompatibility antigen, K-B alpha chain
RNA binding, beta-2-microglobulin binding, peptide antigen binding, receptor binding

VKOR1_MOUSE
Vitamin K epoxide reductase complex subunit 1
Oxidoreductase activity, quinone binding, vitamin-K-epoxide reductase (warfarin-sensitive) activity

CUL3_MOUSE
Cullin-3
POZ domain binding, cyclin binding, protein binding, protein heterodimerization activity, protein homodimerization activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding

HA11_MOUSE
H-2 class I histocompatibility antigen, D-B alpha chain
RNA binding, beta-2-microglobulin binding, peptide antigen binding, protein binding

ACAD9_MOUSE
Acyl-CoA dehydrogenase family member 9, mitochondrial
Acyl-CoA dehydrogenase activity, electron carrier activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

TGBR3_MOUSE
Transforming growth factor beta receptor type 3
PDZ domain binding, SMAD binding, coreceptor activity, glycosaminoglycan binding, protein binding, transforming growth factor beta binding, transforming growth factor beta receptor activity, type III, transforming growth factor beta-activated receptor activity, type II transforming growth factor beta receptor binding

A4_MOUSE
Amyloid-beta A4 protein
DNA binding, PTB domain binding, enzyme binding, growth factor receptor binding, heparin binding, identical protein binding, peptidase activator activity, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity, transition metal ion binding

RBMS2_MOUSE
RNA-binding motif, single-stranded-interacting protein 2
RNA binding, nucleotide binding

PAPS2_MOUSE
Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2
ATP binding, adenylylsulfate kinase activity, catalytic activity, nucleotide binding, nucleotidyltransferase activity, sulfate adenylyltransferase (ATP) activity

SPA3N_MOUSE
Serine protease inhibitor A3N
Peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

DDX17_MOUSE
Probable ATP-dependent RNA helicase DDX17
ATP binding, ATP-dependent RNA helicase activity, RNA binding, estrogen receptor binding, nucleotide binding, transcription coactivator activity

RIPK3_MOUSE
Receptor-interacting serine/threonine-protein kinase 3
ATP binding, NF-kappaB-inducing kinase activity, identical protein binding, nucleotide binding, protein complex binding

MCAT_MOUSE
Mitochondrial carnitine/acylcarnitine carrier protein
Acyl carnitine transmembrane transporter activity

GDN_MOUSE
Glia-derived nexin
Glycosaminoglycan binding, heparin binding, receptor binding, serine-type endopeptidase inhibitor activity

ERLN2_MOUSE
Erlin-2
Cholesterol binding, protein binding, ubiquitin protein ligase binding

ARPC5_MOUSE
Actin-related protein 2/3 complex subunit 5
Actin filament binding, structural constituent of cytoskeleton

AAAT_MOUSE
Neutral amino acid transporter B(0)
Neutral amino acid transmembrane transporter activity, symporter activity

NAGK_MOUSE
N-Acetyl-D-glucosamine kinase
ATP binding, N-acetylglucosamine kinase activity, N-acylmannosamine kinase activity, kinase activity, nucleotide binding

STAT1_MOUSE
Signal transducer and activator of transcription 1
DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, cadherin binding involved in cell-cell adhesion, double-stranded DNA binding, enzyme binding, nuclear hormone receptor binding, protein homodimerization activity, signal transducer activity, transcription factor activity, RNA polymerase II core promoter sequence-specific, transcription factor activity, sequence-specific DNA binding, tumor necrosis factor receptor binding

CCD47_MOUSE
Coiled-coil domain-containing protein 47
RNA binding, calcium ion binding

NDUB7_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
NADH dehydrogenase (ubiquinone) activity

F13A_MOUSE
Coagulation factor XIII A chain
Metal ion binding, protein-glutamine gamma-glutamyltransferase activity

SUCA_MOUSE
Succinate–CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
GTP binding, RNA binding, cofactor binding, ligase activity, nucleotide binding, succinate-CoA ligase (ADP-forming) activity, succinate-CoA ligase (GDP-forming) activity

FACR1_MOUSE
Fatty acyl-CoA reductase 1
Fatty-acyl-CoA reductase (alcohol-forming) activity, long-chain-fatty-acyl-CoA reductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

EFTS_MOUSE
Elongation factor Ts, mitochondrial
RNA binding, translation elongation factor activity

TM165_MOUSE
Transmembrane protein 165
Molecular function

ADA15_MOUSE
Disintegrin and metalloproteinase domain-containing protein 15
SH3 domain binding, integrin binding, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding

SNP23_MOUSE
Synaptosomal-associated protein 23
SNAP receptor activity, syntaxin binding

PRIO_MOUSE
Major prion protein
ATP-dependent protein binding, chaperone binding, copper ion binding, identical protein binding, ion channel binding, lamin binding, microtubule binding

LY6A_MOUSE
Lymphocyte antigen 6A-2/6E-1

PLP2_MOUSE
Proteolipid protein 2
Chemokine binding

TSNAX_MOUSE
Translin-associated protein X
A2A adenosine receptor binding, RNA binding, metal ion binding, protein complex binding, sequence-specific DNA binding, single-stranded DNA binding

T106A_MOUSE
Transmembrane protein 106A
Molecular function

UBFD1_MOUSE
Ubiquitin domain-containing protein UBFD1
RNA binding, cadherin binding involved in cell-cell adhesion

PLEK_MOUSE
Pleckstrin
Phosphatidylinositol-3,4-bisphosphate binding, protein homodimerization activity, protein kinase C binding

TPBG_MOUSE
Trophoblast glycoprotein

ILEUA_MOUSE
Leukocyte elastase inhibitor A
Serine-type endopeptidase inhibitor activity

TIMP2_MOUSE
Metalloproteinase inhibitor 2
Enzyme activator activity, integrin binding, metal ion binding, metalloendopeptidase inhibitor activity, peptidase inhibitor activity, protease binding

FMR1_MOUSE
Synaptic functional regulator FMR1
G-quadruplex RNA binding, RNA stem-loop binding, RNA strand annealing activity, chromatin binding, dynein complex binding, ion channel binding, mRNA 3-UTR binding, mRNA 5-UTR binding, methylated histone binding, miRNA binding, microtubule binding, poly(G) binding, poly(U) RNA binding, protein heterodimerization activity, protein homodimerization activity, ribosome binding, sequence-specific mRNA binding, siRNA binding, translation initiation factor binding, translation repressor activity

DCUP_MOUSE
Uroporphyrinogen decarboxylase
Carboxy-lyase activity, uroporphyrinogen decarboxylase activity

PLIN4_MOUSE
Perilipin-4

RHEB_MOUSE
GTP-binding protein Rheb
GTP binding, metal ion binding, nucleotide binding, protein kinase binding

TPD52_MOUSE
Tumor protein D52
Calcium ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity

LDLR_MOUSE
Low-density lipoprotein receptor
Calcium ion binding, glycoprotein binding, identical protein binding, low-density lipoprotein particle binding, low-density lipoprotein receptor activity, protease binding, very-low-density lipoprotein particle receptor activity

PDC10_MOUSE
Programmed cell death protein 10
Protein N-terminus binding, protein homodimerization activity, protein kinase binding

UFM1_MOUSE
Ubiquitin-fold modifier 1
Molecular function

SRXN1_MOUSE
Sulfiredoxin-1
ATP binding, antioxidant activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, sulfiredoxin activity

GAPR1_MOUSE
Golgi-associated plant pathogenesis-related protein 1
Protein homodimerization activity

CSN5_MOUSE
COP9 signalosome complex subunit 5
Hydrolase activity, metal ion binding, metallopeptidase activity, protein binding, thiol-dependent ubiquitin-specific protease activity, transcription coactivator activity

OCAD1_MOUSE
OCIA domain-containing protein 1
Molecular function

DCAKD_MOUSE
Dephospho-CoA kinase domain-containing protein
ATP binding, dephospho-CoA kinase activity, nucleotide binding

CD166_MOUSE
CD166 antigen
Protein binding

ATG3_MOUSE
Ubiquitin-like-conjugating enzyme ATG3
Atg12 transferase activity, Atg8 ligase activity, enzyme binding, ligase activity, ubiquitin-like protein transferase activity

DAG1_MOUSE
Dystroglycan
SH2 domain binding, actin binding, alpha-actinin binding, calcium ion binding, dystroglycan binding, protein binding, protein complex binding, structural constituent of muscle, tubulin binding, vinculin binding

RAP2A_MOUSE
Ras-related protein Rap-2a
GTP binding, GTPase activity, nucleotide binding, protein binding

MPEG1_MOUSE
Macrophage-expressed gene 1 protein

RBX1_MOUSE
E3 ubiquitin-protein ligase RBX1
NEDD8 transferase activity, cullin family protein binding, eukaryotic initiation factor 4E binding, ligase activity, protein complex binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-ubiquitin ligase activity, zinc ion binding

VPS16_MOUSE
Vacuolar protein sorting-associated protein 16 homolog
Actin binding

PKHO2_MOUSE
Pleckstrin homology domain-containing family O member 2
Molecular function

GAS6_MOUSE
Growth arrest-specific protein 6
Binding, bridging, calcium ion binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, phosphatidylserine binding, protein tyrosine kinase activator activity, receptor agonist activity, receptor binding, receptor tyrosine kinase binding, voltage-gated calcium channel activity

GMPPA_MOUSE
Mannose-1-phosphate guanyltransferase alpha
Nucleotidyltransferase activity, transferase activity

COMD4_MOUSE
COMM domain-containing protein 4
Molecular function

MECR_MOUSE
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Ligand-dependent nuclear receptor binding, oxidoreductase activity, trans-2-enoyl-CoA reductase (NADPH) activity, zinc ion binding

PTMS_MOUSE
Parathymosin
Zinc ion binding

RMD3_MOUSE
Regulator of microtubule dynamics protein 3
Molecular function

SRSF1_MOUSE
Serine/arginine-rich splicing factor 1
RNA binding, RS domain binding, mRNA binding, nucleotide binding, protein kinase B binding

TMCO1_MOUSE
Calcium load-activated calcium channel
Calcium channel activity

TMX1_MOUSE
Thioredoxin-related transmembrane protein 1
Disulfide oxidoreductase activity, protein disulfide isomerase activity

VATG1_MOUSE
V-type proton ATPase subunit G 1
ATPase activity, ATPase binding, hydrogen-exporting ATPase activity, phosphorylative mechanism, hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

STMN1_MOUSE
Stathmin
Protein binding, tubulin binding

H14_MOUSE
Histone H1.4
DNA binding, RNA binding, chromatin DNA binding, protein binding

PROS_MOUSE
Vitamin K-dependent protein S
Calcium ion binding

PP2BA_MOUSE
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding, calmodulin-dependent protein phosphatase activity, drug binding, enzyme binding, hydrolase activity, metal ion binding, protein dimerization activity, protein heterodimerization activity

VAPB_MOUSE
Vesicle-associated membrane protein-associated protein B
FFAT motif binding, beta-tubulin binding, cadherin binding involved in cell-cell adhesion, enzyme binding, microtubule binding, protein heterodimerization activity, protein homodimerization activity

TBL1R_MOUSE
F-box-like/WD repeat-containing protein TBL1XR1
DNA binding, beta-catenin binding, histone binding, protein N-terminus binding, protein binding, transcription corepressor activity, transcription regulatory region DNA binding

RAB35_MOUSE
Ras-related protein Rab-35
GDP binding, GTP binding, GTPase activity, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding

BID_MOUSE
BH3-interacting domain death agonist
Protein heterodimerization activity, ubiquitin protein ligase binding

GLTP_MOUSE
Glycolipid transfer protein
Glycolipid binding, glycolipid transporter activity

IL1RA_MOUSE
Interleukin-1 receptor antagonist protein
Cytokine activity, interleukin-1 Type I receptor antagonist activity, interleukin-1 Type II receptor antagonist activity, interleukin-1, Type I receptor binding, interleukin-1, Type II receptor binding

PDXK_MOUSE
Pyridoxal kinase
ATP binding, kinase activity, lithium ion binding, magnesium ion binding, nucleotide binding, potassium ion binding, protein homodimerization activity, pyridoxal kinase activity, pyridoxal phosphate binding, sodium ion binding, zinc ion binding

TRI25_MOUSE
E3 ubiquitin/ISG15 ligase TRIM25
RNA binding, acid-amino acid ligase activity, cadherin binding involved in cell-cell adhesion, ligase activity, metal ion binding, ubiquitin protein ligase activity involved in ERAD pathway, ubiquitin-protein transferase activity, zinc ion binding

VATD_MOUSE
V-type proton ATPase subunit D
ATPase activity, coupled to transmembrane movement of substances

IL1AP_MOUSE
Interleukin-1 receptor accessory protein
Interleukin-1 receptor activity, interleukin-33 receptor activity, protein tyrosine kinase binding, signal transducer activity

SFXN1_MOUSE
Sideroflexin-1
Ion transmembrane transporter activity

EEA1_MOUSE
Early endosome antigen 1
1-Phosphatidylinositol binding, GTP-dependent protein binding, metal ion binding, protein homodimerization activity

CBR2_MOUSE
Carbonyl reductase [NADPH] 2
Carbonyl reductase (NADPH) activity, oxidoreductase activity, protein binding, protein self-association

FKB14_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP14
FK506 binding, calcium ion binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity

DEGS1_MOUSE
Sphingolipid delta(4)-desaturase DES1
Sphingolipid delta-4 desaturase activity

FCGRN_MOUSE
IgG receptor FcRn large subunit p51
IgG binding, IgG receptor activity, antigen binding, beta-2-microglobulin binding, peptide antigen binding

ACSF2_MOUSE
Acyl-CoA synthetase family member 2, mitochondrial
ATP binding, ligase activity, molecular function, nucleotide binding

ADA_MOUSE
Adenosine deaminase
Adenosine deaminase activity, deaminase activity, hydrolase activity, purine nucleoside binding, zinc ion binding

ASC_MOUSE
Apoptosis-associated speck-like protein containing a CARD
BMP receptor binding, Pyrin domain binding, cysteine-type endopeptidase activity involved in apoptotic process, enzyme binding, interleukin-6 receptor binding, ion channel binding, myosin I binding, peptidase activator activity involved in apoptotic process, protease binding, protein dimerization activity, protein homodimerization activity, tropomyosin binding

TXD17_MOUSE
Thioredoxin domain-containing protein 17
Peroxidase activity, protein-disulfide reductase activity

MXRA8_MOUSE
Matrix remodeling-associated protein 8
Molecular function

COX6C_MOUSE
Cytochrome c oxidase subunit 6C
Cytochrome c oxidase activity, molecular function

COASY_MOUSE
Bifunctional coenzyme A synthase
ATP binding, dephospho-CoA kinase activity, nucleotide binding, pantetheine-phosphate adenylyltransferase activity, transferase activity

CHCH2_MOUSE
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2
Sequence-specific DNA binding, transcription factor binding

SHOC2_MOUSE
Leucine-rich repeat protein SHOC-2
Protein phosphatase 1 binding, protein phosphatase binding

CDV3_MOUSE
Protein CDV3
Molecular function

ERAP1_MOUSE
Endoplasmic reticulum aminopeptidase 1
Endopeptidase activity, interleukin-6 receptor binding, metalloaminopeptidase activity, metalloexopeptidase activity, peptide binding, zinc ion binding

AL3A2_MOUSE
Fatty aldehyde dehydrogenase
3-Chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, aldehyde dehydrogenase [NAD(P)+] activity, long-chain-alcohol oxidase activity

ABHEB_MOUSE
Protein ABHD14B
Hydrolase activity

GLYG_MOUSE
Glycogenin-1
Glycogenin glucosyltransferase activity, metal ion binding, transferase activity, transferase activity, transferring glycosyl groups

BPNT1_MOUSE
3(2),5-Bisphosphate nucleotidase 1
3(2),5-Bisphosphate nucleotidase activity, hydrolase activity, magnesium ion binding, metal ion binding

IFM2_MOUSE
Interferon-induced transmembrane protein 2
Molecular function

PFD6_MOUSE
Prefoldin subunit 6
Chaperone binding, unfolded protein binding

COMD8_MOUSE
COMM domain-containing protein 8
Molecular function

S10AD_MOUSE
Protein S100-A13
RAGE receptor binding, calcium ion binding, copper ion binding, fibroblast growth factor binding, lipid binding, metal ion binding, protein homodimerization activity, zinc ion binding

T176A_MOUSE
Transmembrane protein 176A
Protein binding

SPD2B_MOUSE
SH3 and PX domain-containing protein 2B
SH2 domain binding, phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, superoxide-generating NADPH oxidase activator activity

RM46_MOUSE
39S ribosomal protein L46, mitochondrial
Hydrolase activity, structural constituent of ribosome

ADAS_MOUSE
Alkyldihydroxyacetonephosphate synthase, peroxisomal
FAD binding, alkylglycerone-phosphate synthase activity, flavin adenine dinucleotide binding, oxidoreductase activity, acting on CH-OH group of donors

APMAP_MOUSE
Adipocyte plasma membrane-associated protein
Arylesterase activity, hydrolase activity, acting on ester bonds, strictosidine synthase activity

ARK72_MOUSE
Aflatoxin B1 aldehyde reductase member 2
Oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, phenanthrene-9,10-epoxide hydrolase activity

BST2_MOUSE
Bone marrow stromal antigen 2
RNA binding, metalloendopeptidase inhibitor activity, protein homodimerization activity, signal transducer activity

CASP1_MOUSE
Caspase-1
Cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type peptidase activity, protein binding

CD180_MOUSE
CD180 antigen
Receptor activity

CK054_MOUSE
Ester hydrolase C11orf54 homolog
Hydrolase activity, acting on ester bonds, metal ion binding, zinc ion binding

COX7C_MOUSE
Cytochrome c oxidase subunit 7C, mitochondrial
Cytochrome c oxidase activity

CPSF7_MOUSE
Cleavage and polyadenylation specificity factor subunit 7
RNA binding, nucleotide binding

DCAF8_MOUSE
DDB1- and CUL4-associated factor 8
Molecular function

DHB11_MOUSE
Estradiol 17-beta-dehydrogenase 11
Estradiol 17-beta-dehydrogenase activity, steroid dehydrogenase activity

ERGI1_MOUSE
Endoplasmic reticulum-Golgi intermediate compartment protein 1
Molecular function

ERGI3_MOUSE
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Molecular function

FKB15_MOUSE
FK506-binding protein 15
Actin binding, peptidyl-prolyl cis-trans isomerase activity

GSTA1_MOUSE
Glutathione S-transferase A1
Glutathione transferase activity, transferase activity

IL4RA_MOUSE
Interleukin-4 receptor subunit alpha
Cytokine receptor activity, protein binding

ILF2_MOUSE
Interleukin enhancer-binding factor 2
ATP binding, DNA binding, RNA binding, double-stranded RNA binding, transferase activity

ITAM_MOUSE
Integrin alpha-M
Glycoprotein binding, heparan sulfate proteoglycan binding, heparin binding, metal ion binding, opsonin binding

LSG1_MOUSE
Large subunit GTPase 1 homolog
GTP binding, GTPase activity, nucleotide binding

NDUA2_MOUSE
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
NADH dehydrogenase (ubiquinone) activity

NINJ1_MOUSE
Ninjurin-1

OSMR_MOUSE
Oncostatin-M-specific receptor subunit beta
Cytokine binding, cytokine receptor activity, growth factor binding, oncostatin-M receptor activity

P2RX4_MOUSE
P2X purinoceptor 4
ATP binding, cadherin binding, extracellular ATP-gated cation channel activity, ion channel activity, purinergic nucleotide receptor activity

PFD1_MOUSE
Prefoldin subunit 1
Protein binding involved in protein folding, unfolded protein binding

PGFS_MOUSE
Prostamide/prostaglandin F synthase
Prostaglandin-F synthase activity, thioredoxin peroxidase activity

PR2C2_MOUSE
Prolactin-2C2
Growth factor activity, hormone activity

PRRX1_MOUSE
Paired mesoderm homeobox protein 1
DNA binding, HMG box domain binding, RNA polymerase II transcription coactivator activity, sequence-specific DNA binding

RL35_MOUSE
60S ribosomal protein L35
RNA binding, mRNA binding, structural constituent of ribosome

S10A1_MOUSE
Protein S100-A1
ATPase binding, S100 protein binding, calcium ion binding, protein homodimerization activity

SBDS_MOUSE
Ribosome maturation protein SBDS
Microtubule binding, rRNA binding, ribosome binding

SDF2_MOUSE
Stromal cell-derived factor 2
Dolichyl-phosphate-mannose-protein mannosyltransferase activity

SERC1_MOUSE
Serine incorporator 1
L-Serine transmembrane transporter activity

TIAR_MOUSE
Nucleolysin TIAR
AU-rich element binding, RNA binding, nucleotide binding

TRADD_MOUSE
Tumor necrosis factor receptor type 1-associated DEATH domain protein
Binding, bridging, death domain binding, identical protein binding, kinase binding, protein complex binding, signal transducer activity, tumor necrosis factor receptor binding

TRNT1_MOUSE
CCA tRNA nucleotidyltransferase 1, mitochondrial
ATP binding, ATP:3-cytidine-cytidine-tRNA adenylyltransferase activity, CTP:3-cytidine-tRNA cytidylyltransferase activity, CTP:tRNA cytidylyltransferase activity, nucleotide binding, tRNA binding, tRNA nucleotidyltransferase activity

VPS52_MOUSE
Vacuolar protein sorting-associated protein 52 homolog
Syntaxin binding

ZFYV1_MOUSE
Zinc finger FYVE domain-containing protein 1
1-Phosphatidylinositol binding, metal ion binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding

ZWINT_MOUSE
ZW10 interactor
Protein N-terminus binding, protein binding

FBLN3_MOUSE
EGF-containing fibulin-like extracellular matrix protein 1
Calcium ion binding, epidermal growth factor receptor binding, epidermal growth factor-activated receptor activity, growth factor activity

NDUB9_MOUSE
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
NADH dehydrogenase (ubiquinone) activity

MIC10_MOUSE
MICOS complex subunit Mic10
Molecular function

NPL_MOUSE
N-Acetylneuraminate lyase
N-Acetylneuraminate lyase activity, lyase activity

UCRI_MOUSE
Cytochrome b-c1 complex subunit Rieske, mitochondrial
2 iron, 2 sulfur cluster binding, metal ion binding, oxidoreductase activity, acting on diphenols and related substances as donors, protein complex binding, ubiquinol-cytochrome c reductase activity

CD97_MOUSE
CD97 antigen
G-protein coupled receptor activity, calcium ion binding, signal transducer activity

WDR26_MOUSE
WD repeat-containing protein 26
Molecular function

XIRP2_MOUSE
Xin actin-binding repeat-containing protein 2
Actin binding, alpha-actinin binding, protein binding, zinc ion binding

DYR_MOUSE
Dihydrofolate reductase
NADP binding, NADPH binding, dihydrofolate reductase activity, dihydrofolic acid binding, folic acid binding, mRNA binding, methotrexate binding, oxidoreductase activity

AIMP1_MOUSE
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
GTPase binding, cytokine activity, protein homodimerization activity, tRNA binding

SYTC2_MOUSE
Probable threonine–tRNA ligase 2, cytoplasmic
ATP binding, RNA binding, nucleotide binding, threonine-tRNA ligase activity

RAB4B_MOUSE
Ras-related protein Rab-4B
GTP binding, nucleotide binding

RAB8A_MOUSE
Ras-related protein Rab-8A
GDP binding, GTP binding, GTPase activity, Rab GTPase binding, myosin V binding, nucleotide binding, protein binding, protein kinase binding

AT2B1_MOUSE
Plasma membrane calcium-transporting ATPase 1
ATP binding, PDZ domain binding, calcium-transporting ATPase activity, calmodulin binding, hydrolase activity, metal ion binding, nucleotide binding

GNA11_MOUSE
Guanine nucleotide-binding protein subunit alpha-11
G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, alkylglycerophosphoethanolamine phosphodiesterase activity, guanyl nucleotide binding, metal ion binding, signal transducer activity, type 2A serotonin receptor binding

SUCB2_MOUSE
Succinate–CoA ligase [GDP-forming] subunit beta, mitochondrial
ATP binding, GDP binding, GTP binding, ligase activity, metal ion binding, nucleotide binding, protein heterodimerization activity, succinate-CoA ligase (GDP-forming) activity, succinate-semialdehyde dehydrogenase (NAD+) activity

GIPC1_MOUSE
PDZ domain-containing protein GIPC1
GTPase activator activity, PDZ domain binding, actin binding, cadherin binding involved in cell-cell adhesion, myosin binding, protein homodimerization activity, receptor binding

ACPM_MOUSE
Acyl carrier protein, mitochondrial
Molecular function

ALG11_MOUSE
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity, transferase activity, transferase activity, transferring glycosyl groups

AN32E_MOUSE
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Histone binding, phosphatase inhibitor activity

APOE_MOUSE
Apolipoprotein E
Antioxidant activity, beta-amyloid binding, cholesterol binding, cholesterol transporter activity, heparin binding, lipid transporter activity, lipoprotein particle binding, low-density lipoprotein particle receptor binding, metal chelating activity, phosphatidylcholine-sterol O-acyltransferase activator activity, phospholipid binding, protein binding, protein homodimerization activity, tau protein binding, very-low-density lipoprotein particle receptor binding

ARMC6_MOUSE
Armadillo repeat-containing protein 6
Molecular function

BAP31_MOUSE
B cell receptor-associated protein 31
MHC class I protein binding, protein complex binding

CC90B_MOUSE
Coiled-coil domain-containing protein 90B, mitochondrial
Molecular function

CCD22_MOUSE
Coiled-coil domain-containing protein 22
Cullin family protein binding, protein binding

CDIPT_MOUSE
CDP-diacylglycerol–inositol 3-phosphatidyltransferase
CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity, alcohol binding, carbohydrate binding, diacylglycerol binding, manganese ion binding

CGAT1_MOUSE
Chondroitin sulfate N-acetylgalactosaminyltransferase 1
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glucuronosyltransferase activity, glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, metal ion binding, peptidoglycan glycosyltransferase activity

CN37_MOUSE
2,3-Cyclic-nucleotide 3-phosphodiesterase
2,3-Cyclic-nucleotide 3-phosphodiesterase activity, RNA binding, cyclic nucleotide binding, hydrolase activity

CO4A2_MOUSE
Collagen alpha-2(IV) chain
Extracellular matrix structural constituent

CPSF6_MOUSE
Cleavage and polyadenylation specificity factor subunit 6
RNA binding, mRNA binding, nucleotide binding

CRK_MOUSE
Adapter molecule crk
SH2 domain binding, SH3/SH2 adaptor activity, enzyme binding, ephrin receptor binding, protein binding, bridging, protein phosphorylated amino acid binding

CTBP2_MOUSE
C-terminal-binding protein 2
NAD binding, chromatin binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein homodimerization activity, retinoic acid receptor binding, transcription coactivator activity, transcription corepressor activity

DAD1_MOUSE
Dolichyl-diphosphooligosaccharide–protein glycosyltransferase subunit DAD1
Dolichyl-diphosphooligosaccharide-protein glycotransferase activity, transferase activity, transferring glycosyl groups

DERL2_MOUSE
Derlin-2
Molecular function

DHSO_MOUSE
Sorbitol dehydrogenase
D-Xylulose reductase activity, L-iditol 2-dehydrogenase activity, NAD binding, identical protein binding, zinc ion binding

DNJB4_MOUSE
DnaJ homolog subfamily B member 4
Chaperone binding, unfolded protein binding

DYLT1_MOUSE
Dynein light chain Tctex-type 1
G-protein beta-subunit binding, GTP-dependent protein binding, identical protein binding, motor activity

DYLT3_MOUSE
Dynein light chain Tctex-type 3
Identical protein binding, motor activity

EFL1_MOUSE
Elongation factor-like GTPase 1
GTP binding, GTPase activity, nucleotide binding, ribosome binding

EH1L1_MOUSE
EH domain-binding protein 1-like protein 1
Molecular function

EMC8_MOUSE
ER membrane protein complex subunit 8
Molecular function

ETHE1_MOUSE
Persulfide dioxygenase ETHE1, mitochondrial
Dioxygenase activity, iron ion binding, metal ion binding, sulfur dioxygenase activity

FKB11_MOUSE
Peptidyl-prolyl cis-trans isomerase FKBP11
FK506 binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity

FNTB_MOUSE
Protein farnesyltransferase subunit beta
Drug binding, farnesyltranstransferase activity, isoprenoid binding, peptide binding, protein farnesyltransferase activity, zinc ion binding

FUND2_MOUSE
FUN14 domain-containing protein 2
Molecular function

GGA1_MOUSE
ADP-ribosylation factor-binding protein GGA1

GGT5_MOUSE
Glutathione hydrolase 5 proenzyme
Gamma-glutamyltransferase activity, glutathione hydrolase activity

GINM1_MOUSE
Glycoprotein integral membrane protein 1
Molecular function

GLRX5_MOUSE
Glutaredoxin-related protein 5, mitochondrial
2 iron, 2 sulfur cluster binding, electron carrier activity, metal ion binding, protein disulfide oxidoreductase activity

HDAC7_MOUSE
Histone deacetylase 7
14-3-3 protein binding, NAD-dependent histone deacetylase activity (H3-K14 specific), activating transcription factor binding, chromatin binding, metal ion binding, protein kinase C binding, protein kinase binding, repressing transcription factor binding, transcription corepressor activity

HEBP1_MOUSE
Heme-binding protein 1
Heme binding

HIG1A_MOUSE
HIG1 domain family member 1A, mitochondrial
Molecular function

HOME3_MOUSE
Homer protein homolog 3
G-protein coupled glutamate receptor binding, protein C-terminus binding, protein domain specific binding

HRG1_MOUSE
Heme transporter HRG1
Heme transporter activity, molecular function

HS2ST_MOUSE
Heparan sulfate 2-O-sulfotransferase 1
Heparan sulfate 2-O-sulfotransferase activity, transferase activity

IC1_MOUSE
Plasma protease C1 inhibitor
Peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

IDHG1_MOUSE
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
ATP binding, NAD binding, isocitrate dehydrogenase (NAD+) activity, magnesium ion binding, oxidoreductase activity

LRN4L_MOUSE
LRRN4 C-terminal-like protein
Molecular function

LTOR5_MOUSE
Ragulator complex protein LAMTOR5
Guanyl-nucleotide exchange factor activity, protein complex scaffold

LXN_MOUSE
Latexin
Enzyme inhibitor activity, heparin binding, metalloendopeptidase inhibitor activity

MA2B2_MOUSE
Epididymis-specific alpha-mannosidase
Alpha-mannosidase activity, carbohydrate binding, hydrolase activity, mannosidase activity, zinc ion binding

MDR1A_MOUSE
Multidrug resistance protein 1A
ATP binding, ATPase activity, coupled, ATPase activity, coupled to transmembrane movement of substances, ceramide-translocating ATPase activity, nucleotide binding, phosphatidylcholine-translocating ATPase activity, phosphatidylethanolamine-translocating ATPase activity, xenobiotic-transporting ATPase activity

MIC13_MOUSE
MICOS complex subunit MIC13
Molecular function

MMAB_MOUSE
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial
ATP binding, cob(I)yrinic acid a,c-diamide adenosyltransferase activity, nucleotide binding, transferase activity

MMSA_MOUSE
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
RNA binding, aldehyde dehydrogenase (NAD) activity, malonate-semialdehyde dehydrogenase (acetylating) activity, methylmalonate-semialdehyde dehydrogenase (acylating) activity, oxidoreductase activity

MPI_MOUSE
Mannose-6-phosphate isomerase
Isomerase activity, mannose-6-phosphate isomerase activity, zinc ion binding

NAGA_MOUSE
N-Acetylglucosamine-6-phosphate deacetylase
N-Acetylglucosamine-6-phosphate deacetylase activity, hydrolase activity, metal ion binding

NDUS4_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
NADH dehydrogenase (ubiquinone) activity

NDUS5_MOUSE
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Molecular function

NHLC3_MOUSE
NHL repeat-containing protein 3
Molecular function

NU160_MOUSE
Nuclear pore complex protein Nup160
Nucleocytoplasmic transporter activity

NUP50_MOUSE
Nuclear pore complex protein Nup50
Ran GTPase binding

OAS1A_MOUSE
2-5-Oligoadenylate synthase 1A
2-5-Oligoadenylate synthetase activity, ATP binding, double-stranded RNA binding, metal ion binding, nucleotide binding, protein binding, transferase activity

PEDF_MOUSE
Pigment epithelium-derived factor
Serine-type endopeptidase inhibitor activity

PEX14_MOUSE
Peroxisomal membrane protein PEX14
Beta-tubulin binding, microtubule binding, protein N-terminus binding, receptor binding, transcription corepressor activity

PEX19_MOUSE
Peroxisomal biogenesis factor 19
ATPase binding, peroxisome membrane class-1 targeting sequence binding, protein N-terminus binding, protein binding

PIEZ1_MOUSE
Piezo-type mechanosensitive ion channel component 1
Cation channel activity, mechanically-gated ion channel activity

PRAF1_MOUSE
Prenylated Rab acceptor protein 1
Identical protein binding, proline-rich region binding, protein C-terminus binding

PRAF2_MOUSE
PRA1 family protein 2
Molecular function

PREB_MOUSE
Prolactin regulatory element-binding protein
ARF guanyl-nucleotide exchange factor activity, DNA binding, GTPase binding, Rab guanyl-nucleotide exchange factor activity, Sar guanyl-nucleotide exchange factor activity, transcription factor activity, sequence-specific DNA binding

PSN1_MOUSE
Presenilin-1
PDZ domain binding, aspartic-type endopeptidase activity, beta-catenin binding, cadherin binding, calcium channel activity, endopeptidase activity

RAB31_MOUSE
Ras-related protein Rab-31
GDP binding, GTP binding, nucleotide binding

RDH13_MOUSE
Retinol dehydrogenase 13
Oxidoreductase activity

RT11_MOUSE
28S ribosomal protein S11, mitochondrial
mRNA 5-UTR binding, small ribosomal subunit rRNA binding, structural constituent of ribosome

S2546_MOUSE
Solute carrier family 25 member 46
Molecular function

S35F6_MOUSE
Solute carrier family 35 member F6
Molecular function

S39AE_MOUSE
Zinc transporter ZIP14
Ferrous iron transmembrane transporter activity, metal ion transmembrane transporter activity, zinc ion transmembrane transporter activity

SCFD2_MOUSE
Sec1 family domain-containing protein 2
Molecular function

SSRP1_MOUSE
FACT complex subunit SSRP1
DNA binding, RNA binding, chromatin binding

STX2_MOUSE
Syntaxin-2
SNAP receptor activity, SNARE binding, calcium-dependent protein binding, protein dimerization activity

SYVN1_MOUSE
E3 ubiquitin-protein ligase synoviolin
ATPase binding, chaperone binding, ligase activity, ubiquitin protein ligase activity, ubiquitin protein ligase activity involved in ERAD pathway, ubiquitin-specific protease binding, unfolded protein binding, zinc ion binding

TENS3_MOUSE
Tensin-3
Molecular function

TI8AB_MOUSE
Putative mitochondrial import inner membrane translocase subunit Tim8 A-B
Metal ion binding

TMX2_MOUSE
Thioredoxin-related transmembrane protein 2
Molecular function

TNR12_MOUSE
Tumor necrosis factor receptor superfamily member 12A
Protein binding

TOIP2_MOUSE
Torsin-1A-interacting protein 2
ATPase activator activity, ATPase binding

TOM5_MOUSE
Mitochondrial import receptor subunit TOM5 homolog
Protein transporter activity

TPC13_MOUSE
Trafficking protein particle complex subunit 13
Molecular function

UBP19_MOUSE
Ubiquitin carboxyl-terminal hydrolase 19
Hsp90 protein binding, Lys48-specific deubiquitinase activity, metal ion binding, thiol-dependent ubiquitin-specific protease activity, ubiquitin protein ligase binding

UFSP2_MOUSE
Ufm1-specific protease 2
UFM1 hydrolase activity, cysteine-type peptidase activity, thiolester hydrolase activity

VMP1_MOUSE
Vacuole membrane protein 1
Molecular function

TIMP1_MOUSE
Metalloproteinase inhibitor 1
Cytokine activity, growth factor activity, metal ion binding, metalloendopeptidase inhibitor activity, protease binding

TM9S4_MOUSE
Transmembrane 9 superfamily member 4
Molecular function

PSB8_MOUSE
Proteasome subunit beta type-8
Endopeptidase activity, peptidase activity, threonine-type endopeptidase activity

QCR7_MOUSE
Cytochrome b-c1 complex subunit 7
Ubiquinol-cytochrome c reductase activity

ADA10_MOUSE
Disintegrin and metalloproteinase domain-containing protein 10
SH2 domain binding, SH3 domain binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, protein binding, protein homodimerization activity, protein kinase binding

KCT2_MOUSE
Keratinocyte-associated transmembrane protein 2
Molecular function

NDRG2_MOUSE
Protein NDRG2

YIF1B_MOUSE
Protein YIF1B
Molecular function

TIM8B_MOUSE
Mitochondrial import inner membrane translocase subunit Tim8 B
Metal ion binding

DJC24_MOUSE
DnaJ homolog subfamily C member 24
ATPase activator activity, ferrous iron binding, zinc ion binding

VWA8_MOUSE
von Willebrand factor A domain-containing protein 8
ATP binding, ATPase activity, nucleotide binding

FEN1_MOUSE
Flap endonuclease 1
5-3 exonuclease activity, 5-flap endonuclease activity, DNA binding, RNA-DNA hybrid ribonuclease activity, catalytic activity, exonuclease activity, flap endonuclease activity, magnesium ion binding, manganese ion binding

TPD54_MOUSE
Tumor protein D54
RNA binding

MCL1_MOUSE
Induced myeloid leukemia cell differentiation protein Mcl-1 homolog
BH3 domain binding, protein heterodimerization activity, protein homodimerization activity

PCBP4_MOUSE
Poly(rC)-binding protein 4
DNA binding, RNA binding, mRNA 3 -UTR binding

GCR_MOUSE
Glucocorticoid receptor
RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity, lipid binding, metal ion binding, protein complex binding, protein dimerization activity, sequence-specific DNA binding, steroid hormone binding, transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding, zinc ion binding

RT16_MOUSE
28S ribosomal protein S16, mitochondrial
Structural constituent of ribosome

CD47_MOUSE
Leukocyte surface antigen CD47
Protein binding, thrombospondin receptor activity

UBP24_MOUSE
Ubiquitin carboxyl-terminal hydrolase 24
Peptidase activity, thiol-dependent ubiquitinyl hydrolase activity

ROMO1_MOUSE
Reactive oxygen species modulator 1
Molecular function

GOT1B_MOUSE
Vesicle transport protein GOT1B
Signal transducer activity

OLR1_MOUSE
Oxidized low-density lipoprotein receptor 1
Carbohydrate binding, low-density lipoprotein receptor activity

SRSF2_MOUSE
Serine/arginine-rich splicing factor 2
RNA binding, nucleotide binding, pre-mRNA binding, protein kinase C binding

COMD2_MOUSE
COMM domain-containing protein 2
Molecular function

PYGL_MOUSE
Glycogen phosphorylase, liver form
AMP binding, ATP binding, bile acid binding, carbohydrate binding, catalytic activity, drug binding, glycogen phosphorylase activity, nucleotide binding, protein homodimerization activity, purine nucleobase binding, pyridoxal phosphate binding, vitamin binding

NCF2_MOUSE
Neutrophil cytosol factor 2
Rac GTPase binding, protein C-terminus binding, superoxide-generating NADPH oxidase activity

YIF1A_MOUSE
Protein YIF1A
Molecular function

PEPL1_MOUSE
Probable aminopeptidase NPEPL1
Aminopeptidase activity, manganese ion binding, metalloexopeptidase activity

WWOX_MOUSE
WW domain-containing oxidoreductase
RNA polymerase II transcription coactivator activity, enzyme binding, oxidoreductase activity

PTH_MOUSE
Probable peptidyl-tRNA hydrolase
RNA binding, aminoacyl-tRNA hydrolase activity

PYRD_MOUSE
Dihydroorotate dehydrogenase (quinone), mitochondrial
FMN binding, dihydroorotate dehydrogenase activity, drug binding, ubiquinone binding

CTL1_MOUSE
Choline transporter-like protein 1
Choline transmembrane transporter activity

LY6C1_MOUSE
Lymphocyte antigen 6C1

OTU6B_MOUSE
OTU domain-containing protein 6B
Thiol-dependent ubiquitinyl hydrolase activity

NECT2_MOUSE
Nectin-2
Cell adhesion molecule binding, identical protein binding, protein heterodimerization activity, protein homodimerization activity, receptor activity, receptor binding

TTYH2_MOUSE
Protein tweety homolog 2
Chloride channel activity, molecular function

LMOD1_MOUSE
Leiomodin-1
Actin binding, tropomyosin binding

UD16_MOUSE
UDP-glucuronosyltransferase 1-6
Glucuronosyltransferase activity, protein heterodimerization activity, protein homodimerization activity, transferase activity, transferring hexosyl groups

MYL6B_MOUSE
Myosin light chain 6B
Calcium ion binding, motor activity, structural constituent of muscle

3.5. Relationship of the Quantitative Value (Normalized emPAI) per Housekeeping Gene of mMSC-ATs (P0 and P3)

The quantitative values of the proteins expressed in both mMSC-ATs (P0) and mMSC-ATs (P3) were represented with a scatter plot (-axis = P3, -axis = P0). The average quantitative value of P3-expressed proteins decreased to 69.4% compared to P0-expressed proteins (Atp5f1, B2m, Hprt1, Rplp1, Ppia, Rps18, Pgk1, Tfrc, Ywhaz, and Gapdh; Supplementary Figure 1). The quantitative values of Tubb5, Flnb, Tln1, Col1a1, Iqgap1, Hspa5, Flnc, Thbs1, Fn1, Prdx1, Rnh1, Col1a2, Vcl, Lcp1, and Fabp5 were higher at P0 than at P3. The quantitative value of Act2, Serponh1, Hsp90ab1, Hsp90aa1, Actbl2, Vdac1, S100a11, Anxa2, S100a6, Pgam1, argininosuccinate synthase (Ass1, which is regulated by hypoxia-inducible factor 1α (Hif1α)), Plec, Kpnb1, Gsn, Marcks, Eif5a, and Tpm4 was higher at P3 than at P0 (Figure 4).

Figure 4: A scatter plot of the quantitative value (normalized emPAI) per housekeeping gene. A scatter plot showing correlation (; gray band indicates “”) between the quantitative value of the mouse primary cultured cells (P0) and cells passaged 3 times (P3) (). The dotted line is the regression line. The two lines indicate the 95% confidence interval. Each dot shows the abbreviated name of the protein.

We previously examined the protein components expressed by human MSC-ATs (hMSC-ATs) cultured in the clinical medium not containing FBS and hMSC-ATs cultured in DMEM containing FBS [25]. Based on the results of the protein expression analysis, the expression of TLN1, FLNC, and ASS1 was higher in hMSC-ATs cultured in DMEM containing FBS than in those cultured in the clinical culture medium. Therefore, the increased expression of Tln1, Flnc, and Ass1 protein at P3 compared with P0 is not caused by FBS. Regarding the change in the expression of Ass1, the activation level of Hif1α was considered to be higher at P0 than at P3, because the oxygen concentration is lower in vivo than in vitro [29, 30]. Therefore, the results of this study reflect not only the effect of cell division frequency but also the influence of oxygen concentration. When cultured cells are planted in a living body in a low-oxygen environment, the hypoxic response may be activated. Therefore, in order to interpret the results of this study more accurately, we must obtain data on the protein expression of MSCs cultured under hypoxic and high-oxygen conditions.

4. Conclusions

The functions of proteins classified by the GO analysis were quantified using the LC-MS/MS measurement system for the amount of proteins and components contained in primary cultured cells of mMSC-ATs and cells passaged three times. The ability of mMSC-ATs to differentiate into expression markers of cells, fat, and osteoblasts did not change, even after three passages. However, the protein expression decreased to 69.4%. The proteins whose expression levels decreased after three passages included Ass1 among the Hif-related proteins. Furthermore, it was revealed that 336 kinds of proteins are specifically expressed in primary cultured MSC-ATs. In conclusion, MSC-ATs used as therapeutic cells retained their cell properties after three passages but showed a decreased protein expression on LC-MS/MS.

Data Availability

The data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest

The authors declare no conflicts of interest in association with the present study.

Authors’ Contributions

YN, SN, CS, and HN were assigned for the study design and study conducts. YN, SN, CS, TK, and HN were assigned for data collection, data analysis, and data interpretation. TK, NK, IS, MW, and JF were assigned for the provision of materials. YN, SN, and HN drafted the manuscript. YN, SN, and HN revised the content of the manuscript. All authors approved the final version of the manuscript. YN takes responsibility for the integrity of all of the data analyses.

Acknowledgments

We thank Naomi Kakazu (University of the Ryukyus) for clerical assistance and Saki Uema, Yuka Onishi, Maki Higa, Yuki Kawahira, and Saori Adaniya (University of the Ryukyus) for providing technical support. This work was supported by the Research Laboratory Center, Faculty of Medicine, and the Institute for Animal Experiments, Faculty of Medicine, University of the Ryukyus. This work was supported in part by the Japan Society for the Promotion of Science (JSPS; KAKENHI Grant numbers JP16H05404, JP16K10435, and JP18K08545), Japan Agency for Medical Research and Development, the Naito Foundation, and Okinawa Science and Technology Promotion Center (OSTC).

Supplementary Materials

Supplementary Figure 1: a scatter plot of the housekeeping genes’ quantitative values. A scatter plot showing the correlation () between the quantitative value of the mouse primary cultured cells (P0) and cells passaged 3 times (P3): Atp5f1, B2m, Hprt1, Rplp1, Ppia, Rps18, Pgk1, Tfrc, Ywhaz, and Gapdh (). The dotted line is the regression line. Each dot shows the abbreviated name of the protein. (Supplementary Materials)

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