Outcomes of Patients Who Have Do Not Resuscitate Status prior to Being Admitted to an Intensive Care Unit

Admission of patients who have do not resuscitate (DNR) status to an intensive care unit (ICU) is potentially a misallocation of limited resources to patients who may neither need nor want intensive care. Yet, patients who have DNR status are often admitted to the ICU. This is a retrospective review of patients who had a valid DNR status at the time that they were admitted to an ICU in a single hospital over an eighteen-month period. Thirty-five patients met the criteria for inclusion in the study. The primary reasons for admission to the ICU were respiratory distress (54.2%) and sepsis (45.7%). Sixteen (45.7%) of the patients died, compared to a 5.4% mortality rate for all patients admitted to our ICU during this period (p < 0.001). APACHE II score was a significant predictor of mortality (18.5 ± 1.3 alive and 23.4 ± 1.4 dead; p = 0.038). Of the 19 patients discharged alive, 9 were discharged home, 5 to hospice, and 4 to a post-acute care facility. Conclusions. Patients who have DNR status and are admitted to the ICU have a higher mortality than other ICU patients. Those who survive have a high likelihood of being discharged to hospice or a post-acute care facility. The value of intensive intervention for these patients is not supported by these results. Only a minority of patients were seen by palliative care and chaplain teams, services which the literature supports as valuable for DNR patients. Our study supports the need for less expensive and less intensive but more appropriate resources for patients and families who have chosen DNR status.


Introduction
As the population ages and medical technology enables physicians to prolong the lives of patients with terminal diagnoses, DNR orders appear more frequently in patients' medical records. It is universally accepted for patients with DNR orders to not want intervention when signs of life cease, but there is considerable ambiguity about the level of treatment that is indicated for or desired by these patients when they present to the Emergency Department or to a physician's office with a treatable condition. When this condition is potentially life threatening and might better be treated with intensive intervention, these patients are often admitted to an ICU. The impact of caring for DNR patients in the ICU has not been fully evaluated [1]. Current literature addresses only 28-day mortality for patients admitted to ICU with DNR status (OR 3.64; CI 3.14-4.21, < 0.001) [2]. Increasing our understanding of the impact of ICU care for DNR patients may result in increased patient and family satisfaction and physician and staff satisfaction and improved ICU utilization. There is a need for increased data on evidence based end of life care [3].

Methods
This is a retrospective chart analysis reviewed and approved by the Mount Sinai Medical Center (MSMC) Institutional Review Board. The MSMC electronic health record (EHR)

Results
During  Of the 15 patients intubated, 8 (53%) did not survive to discharge. Seven of the 8 who did not survive to discharge had acute respiratory distress; one was postoperative. Among the 19 who received pressor therapy, 13 died (68%). Among the 4 (11%) who underwent hemodialysis while in the ICU, only one survived to discharge. Ten received both pressor therapy and endotracheal intubation. The mortality in this subgroup of patients was 70% (Table 2). Mean ICU length of stay for patients who survived to discharge was 4.2 days (CI = 2.7-5.7) and for patients who died in hospital was 3 days (CI = 1.5-4.5). Eleven patients (31%, 95% CI: 24-28%) had palliative care consults and 5 (14%; 95% CI: 8.2-19.8%) saw a chaplain. Of the patients who survived, 9 were discharged to their home, 5 were discharged to hospice, and 4 were discharged to a postacute care facility. In total, 25 of the 35 (71%; 95% CI: 63.3-78.7%) DNR patients who were admitted to the ICU died or could not care for themselves in the home environment.

Limitations
This is a retrospective chart review study. We were dependent on nursing and physician documentation in the EHR, which may not have been complete or comprehensive. The study was performed at a single medical center. Patient, family, physician, and nursing culture may play a significant role in clinical decision making. In our cohort, we do not present data on comorbidity other than the APACHE II score, which is likely an important determinant of median to long-term survival of patients with critical illness with and without DNR status [4]. As all patients had DNR status prior to admission to an ICU, our reported cohort does not include patients admitted to an ICU after major elective or nonemergency surgery, and hence our results are not applicable to patients with DNR status who require ICU admission after such events.

Conclusions/Discussion
With the aging of the population and the increased availability of life prolonging medical technology, end of life care has become an important aspect of all medial practice [5]. Regulatory agencies encourage or mandate that providers ask patients to affirm their wishes concerning their end of life care [6]. There is insufficient data about the factors that impact DNR and end of life decision making.
Health care spending and more efficient use of resources are also becoming an increasingly prominent part of medical practice, and there is insufficient evidence to guide the use of intensive interventions as treatments for patients who choose to limit life sustaining technologies [1,5]. This study reports the outcomes of DNR patients who were admitted to an intensive care unit in a single medical center during an 18month period. These patients represent a small percentage (0.48%) of the total patients admitted during the study period. They had a high mortality. Sixteen (45.7%) did not survive to hospital discharge, and those who were discharged had a high likelihood of being transferred to a hospice or post-acute care facility. These results suggest the importance of regular and repeated discussions with patients and families about their wishes regarding end of life care when diagnosis is a terminal or critical illness. Our patients were infrequently consulted to palliative care and chaplain assistance, despite the fact that these interventions have been determined to have significant value to patients and their families at end of life [7,8]. This single site, retrospective study highlights the need for further investigation into the efficacy of ICU admission for DNR patients as well as the need for advancing the evidence based practice of end of life care.