ENGAGE: Guided Activity-Based Gaming in Neurorehabilitation after Stroke: A Pilot Study

Introduction. Stroke is a leading cause of disability in healthy adults. The purpose of this pilot study was to assess the feasibility and outcomes of a novel video gaming repetitive practice paradigm, (ENGAGE) enhanced neurorehabilitation: guided activity-based gaming exercise. Methods. Sixteen individuals at least three months after stroke served as participants. All participants received concurrent outpatient therapy or took part in a stroke exercise class and completed at least 500 minutes of gaming. Primary baseline and posttest outcome measures included the Wolf motor function test (WMFT) and the Fugl-Meyer assessment (FMA). ENGAGE uses a game selection algorithm providing focused, graded activity-based repetitive practice that is highly individualized and directed. The Wilcoxon signed ranks test was used to determine statistical significance. Results. There were improvements in the WMFT (P = 0.003) and the FMA (P = 0.002) that exceeded established values of minimal clinically important difference. Conclusions. ENGAGE was feasible and an effective adjunct to concurrent therapy after stroke.


Introduction
Stroke is one of the leading causes of disability in the United States with approximately 795,000 people experiencing stroke each year [1]. Many of these individuals are left with residual upper extremity deficits that limit independence with activities of daily living [2] and have been correlated with decreased self-reported quality of life [3]. Current research suggests that task-specific practice results in more functional improvement than traditional neuromuscular rehabilitation (TNR) [4][5][6]. TNR after stroke has been defined as a typical contemporary practice that includes a combination of active, impairment-based exercises, functional task practice, passive exercise, and activities to enhance sensory inputs [2,7]. However, based on an observational study by Lang and colleagues [7], only 25% of a typical 36-minute upper extremity therapy session involved functional task practice. While the number of practice repetitions required in task-specific practice is not yet fully delineated, it is thought that individuals after stroke must practice for a minimum of several thousand repetitions in order to relearn a task [5].
Several obstacles exist to obtaining adequate practice. First, there are a large number of tasks to be practiced, and while there is some transfer of learning between similar tasks, such as picking up a coffee mug and a can of soda, practicing these tasks would not necessarily be helpful for learning to write with a pencil [5]. Second, repetitive practice of a single task may be boring both to the patient and the clinician [7][8][9][10]. Third, the learner must actively engage in task practice; it is not adequate to be passively moved through the motion or activity [7,11]. Finally, to ensure optimal movement quality and therapeutic benefit during task practice, a skilled professional must often supervise [8][9][10], making it expensive to provide the necessary hours of training.
Current approaches that provide the opportunity for repetitive practice include constraint-induced therapy (CIT), 2 Stroke Research and Treatment robotics, and virtual reality (VR). In CIT, the individual is forced to practice various tasks repetitively with the hemiparetic arm for six hours a day in a structured environment and for 90% of waking hours, while the nonhemiplegic arm is constrained. Successful candidates for CIT have higher functioning hands, with some active control of wrist and finger extension [6,12]. Both the minimal movement requirement and the intensive structured therapy protocol preclude many patients after stroke from benefiting from this intervention. Robotic instrumentation actively guides movement during repetitive practice, providing partial assistance while also constraining the movement to occur in a specific "correct" movement pattern. These devices have been successfully utilized in people after stroke with both high-and low-level functioning upper extremities primarily in research environments [13,14], but have not been widely adopted in traditional clinical settings. Finally, VR environments provide a three-dimensional computer-generated immersion experience where the "player" completes the task similarly to doing so in the real world. The experience is typically engaging, realistic and has been shown to transfer to a comparable real world activity. VR has been successfully used after stroke and can provide upper extremity repetitive task practice to both lower and higher functioning upper extremities [15,16], but its scalability has been limited due to both size and expense of the equipment requirements.
Video gaming systems such as the Wii and PlayStation II with Eye Toy are commercially available, inexpensive virtual reality-type systems that have been used as an effective adjunct to TNR for individuals with stroke [8-10, 17, 18]. Gaming provides an engaging interaction which is critical in optimizing motor learning [5] and can be easily tailored to individuals with varying degrees of paresis, similarly to some robotic and VR systems, but unlike CIT interventions that are only appropriate for higher functioning arms. Three mechanisms are hypothesized to account for the effectiveness of video gaming in inducing neuroplasticity. First, gaming frequently utilizes more energy than sedentary activities [19] which is important since individuals after stroke are typically less active [20], and enhanced cardiovascular fitness has been shown to improve cortical plasticity [21,22]. Second, gaming offers significant bilateral practice opportunities, hypothesized to effectively induce reorganization in contralesional motor networks [23][24][25][26][27][28]. Finally, during play, the gamer sees an avatar concurrently performing the activity on screen providing visual biofeedback [18,29], similar to techniques using the mirror neuron network after stroke [30,31]. This network involves the activation of neurons in the parietal and premotor cortex during actual movement and when observing others moving [32].
For this study, we developed a novel method of integrating commercially available video gaming into TNR after stroke called ENGAGE, enhanced neurorehabilitation: guided activity-based gaming exercise. The aims of this study were to (1) examine the feasibility of adding ENGAGE as an adjunct to TNR in a natural clinical practice environment without additional skilled therapy personnel costs using commercially available gaming equipment; (2) examine whether practice completed through ENGAGE gaming leads to improvement in upper extremity function in individuals after stroke; (3) examine effects of covariates on the efficacy of ENGAGE gaming, including concurrent rehabilitation, quantity of gaming time, initial motor and sensory function, and chronicity after stroke; (4) examine whether study participants found gaming to be motivating as compared to home exercise program practice.

Study Design.
The study was approved by the Institutional Review Boards for Human Subjects Research at the Cleveland Clinic and Cleveland State University, and informed consent was obtained from each participant. Each participant consented to participating in this study. This study utilized a mixed-methods design, with qualitative measures used to address aim no. 1: feasibility and aim no. 3: covariate analyses. A within-subject pretest posttest design, consistent with the principles of community based participatory research [33] was used to address aim no. 2: improvement in upper extremity function and aim no. 4: motivation. Outcomes were assessed without a control group, evaluating practice in a natural clinical practice environment. Two sites within a regional health system were utilized, representing urban and suburban clinical settings.

Participants.
Patients enrolled in outpatient physical and/or occupational therapy or those participating in a community-based stroke exercise class were eligible to participate. In this pilot study, there was no attempt to control what occurred in concurrent outpatient physical and/or occupational therapy, but activities were consistent with contemporary practice as described by Lang et al. [7] and Miller et al. [2], and included adjuncts such as functional electrical stimulation. Participants in the exercise class completed cardiovascular exercises in addition to basic group stretching and strengthening activities. Inclusion criteria included the following: (1) hemiparesis in the involved upper extremity between Brunnstrom stages 2-6; (2) ≥three months after stroke; (3) sufficient balance to sit safely in unsupported sitting while participating in video gaming; (4) adequate cognitive and communication skills to learn video game within three sessions; (5) the ability to play independently or with support staff assist after set up. Participants were excluded if they had confounding medical interventions during the course of the study, such as upper extremity botox injections. A convenience sample of the 16 participants who completed a minimum of 500 minutes of gaming was included in the outcomes analysis. For this pilot investigation, a minimum of 500 minutes of gaming time was chosen based on the expectation that 12-16 sessions of outpatient rehabilitation is typical before significant improvement occurs, and that each session typically includes a mean of 36 minutes of actual activity [7], resulting in 432-576 minutes of practice. Participant demographics are summarized in Table 1.

Outcomes.
Baseline and posttesting were completed using the upper extremity portion of the Fugl-Meyer assessment and the Wolf motor function test as the primary outcome measures in this pilot investigation. Secondary clinical outcome measures included portions of the stroke impact scale and intrinsic motivation inventory. Detailed training and administration manuals were developed and used by all evaluators for the FMA and WMFT. During posttesting, evaluators were blinded to baseline results. [34]. The upper extremity motor portion of the Fugl-Meyer assessment (FMA) is a 33item test that assesses reflex integrity and active movement. The FMA is measured on an ordinal scale from 0-2 (0 = cannot perform, 1 = performs partially, 2 = performs flawlessly) with a maximum possible score of 66. A study by Lin et al. determined that the FMA has high concurrent validity with P = 0.82-0.96 [35], high interrater reliability (ICC = 0.96), and high test-retest reliability (ICC = 0.99) [36]. The minimal clinically important difference (MCID) for the upper extremity portion of the FMA is 6.6 points, or 10% of the total score of 66 [37]. An additional section of the FMA assesses upper extremity sensation, with two items for light touch and 4 items for proprioception. This section uses the same 0-2 point ordinal scale for a total of 12 points for normal sensation [34]. [38]. The timed tasks of the Wolf motor function test (WMFT) include 15 items that assess gross and fine motor tasks. Psychometric properties have been established, with an interrater reliability of r = 0.97 (P < 0.05) and an internal consistency of 92.4% [38]. Lin and colleagues have determined the MCID to be 1.5 to 2 seconds in subacute stroke [39]. [40]. The stroke impact scale version 3.0 (SIS) is a self-reported quality of life measure that includes 59 questions over eight domains (strength, hand function, activities of daily living (ADL), mobility, communication, emotion, memory and thinking, and participation). The SIS utilizes a 5-point scale where the person rates the difficulty of each item. For this pilot investigation, the ADL (no. 5) and hand function (no. 7) subsections were chosen as most reflective of change expected as a result of the intervention. Lin and colleagues established MCID levels for the ADL and hand function subscales at 5.9 and 17.8 points, respectively [41]. [42]. The interest/ enjoyment subscale of the intrinsic motivation inventory (IMI) is a self-report measure consisting of seven items. Each item is rated on a scale of 1 to 7 according to how true the statement is for the participant. The IMI was used at posttesting, to compare interest/enjoyment in gaming relative to a home exercise program. Validity has been established for this measure [42].

2.4.
Intervention. ENGAGE can be distinguished from standard video gaming in the following ways. First, it uses a game selection algorithm that provides focused, carefully graded activity-based repetitive practice of cognitive-perceptualmotor tasks. It offers highly individualized and directed exercise in the form of playing video games in order to specifically address the unique constellation of each individual's neurological impairments after stroke. Second, it uses a limited number of gaming system platforms and games. Third, it is guided by the neuromuscular rehabilitation clinician, yet carried out under the direct supervision of support personnel or, in this study, students, thereby reducing cost while maintaining the intensity and quality of practice. All clinicians who participated as coinvestigators were experienced neurorehabilitation specialists (17-32 years of experience each).

Game Selection Algorithm.
A game selection algorithm was developed and used in this pilot study. The first step involved determining the specific and unique needs of each individual after stroke. After completion of an initial examination/evaluation by the clinician, the participant and clinician developed a realistic collaborative functional goal, an important factor in obtaining an engaged commitment to practice [36,43,44]. Next, the clinician completed functional task analysis of the goal in conjunction with an assessment of current impairments of body structure/function such as limitations in strength, passive range of motion (PROM), motor control, and sensation that might limit that function/activity. Limiting motor components such as decreased antigravity shoulder flexion were prioritized, as well as critical and interacting nonmotor impairments, such as diminished ability to attend or hemineglect. Games were then selected to bridge the gap between the patient's impairments and the movement required to complete the functional goal. The algorithm allowed for preparatory work on impairments and task components before moving on to practice the actual task, but the gaming itself was always part of a meaningful activity.
In order to efficiently select the appropriate game for a given participant, games utilized in the study were analyzed using a taxonomy representing multiple continua of motor skill difficulty [45] with tables developed to identify these motor components for each game. The first set of factors relating to the environmental demands of playing the game identified whether the environment was stationary (i.e., golfing) or in motion (i.e., batting), and if successful play required force modulation and/or accuracy (i.e., archery). The second set of factors involving the body's interaction with the task demands determined which upper extremity joints needed to move in what planes of motion in relation to gravity (i.e., antigravity shoulder flexion with elbow extension during bowling), whether the task needed specific types of grasp and hand/finger manipulation (i.e., drumming versus playing the guitar), if the task itself was continuous (i.e., boxing) or discrete (i.e., golf swing), and whether it required unilateral or bimanual dexterity (i.e., tennis versus canoeing). The ability to complete bimanual task training was another important feature considered in this model, since bimanual function is variable, utilized in more than 54% of hand activities [46], and has been shown to be an efficacious rehabilitation tool [23,24,[26][27][28]. Bimanual skills were further subdivided into four categories: bimanual assisted (i.e., two-handed activity such as golfing with hemiplegic hand ace wrapped to controller); yoked (i.e., baseball batting); reciprocal (i.e., driving); differing (i.e., playing the guitar). In addition to a game's specific upper extremity motor demands, other critical nonmotor factors were considered. For example, cognitive demands were matched with the patient's ability to understand and learn the game. Associated cardiovascular demands were assessed; in general, continuous tasks (i.e., boxing) that require the player to perform a movement without rest had higher demands than games composed of discrete tasks (i.e., bowling) where there is rest between repetitions. Other nonmotor domains included sensation/perception and trunk control/balance. Changes in these nonmotor areas were not specifically monitored outside of the sensory section of the FMA.

Gaming System Platforms and Games.
Therapists' knowledge of the different game options was essential for appropriate game selection. While an adequate number of games was necessary to meet the varied needs of the different individuals post stroke, this was balanced by the need to know the various game features and requirements. Therefore, games were chosen from six different discs using one of two gaming system platforms, the Sony PlayStation II with EyeToy (games: Play 1, Play 2, and Rock Band) or the Nintendo Wii (games: Wii Sports, Wii Resort, and Wii Play), providing a wide array of options with varying degrees/types of difficulty. The Wii controller contains accelerometers that are actuated by multiplanar tilting, rotation, and acceleration movements, as well as through various control buttons. The EyeToy is a motion-sensitive USB camera that utilizes visual biofeedback by projecting a real time image of the player onto the TV screen. Players see themselves moving within a virtual environment that is superimposed on an image of the actual background [9]. The EyeToy provides more options for individuals with lower functioning arms and/or more cognitive deficits because it is not necessary to activate the accelerometer-based hand controller or manage button controls. Numerous modifications and props were developed to make games more task specific, graded for difficulty, and individualized for the heterogeneous population (i.e., enlarging the wheel during driving, covering unused buttons on the Wii controller). Figure 1 shows an individual playing the game Bubblepop on the PlayStation II with EyeToy, utilizing a precision pinch grasp while holding a pen to pop the bubbles on the screen.

Delegation to Support Personnel.
After completing the above analysis, the treating clinician used a goal recording form as a communication tool for the students completing the intervention with all participants. This form listed the collaborative goal, precautions, the primary motor and secondary nonmotor goals, and a list of possible games addressing these goals along with any required modifications. The assisting students were health sciences undergraduate, graduate, and doctor of physical therapy students. The students were required to know how to use each gaming system and play all the games. Training manuals were developed for this purpose and to serve as a quick reference for trouble shooting during gaming sessions. The supervising clinician was always present during gaming, but was treating other patients. Standardized intervention recording logs were used to track what games were played, how much time was spent playing each game, and modifications to the game.

Analysis
The Wilcoxon signed ranks test was used to calculate differences in the Fugl-Meyer assessment, Wolf motor function test, stroke impact scale, and intrinsic motivation inventory. Data were analyzed using SPSS Version 18 statistical software package. MCIDs were compared to group means for the FMA, WMFT, and SIS (MCID not available for IMI). In addition, for this pilot study, the following covariates were examined: (1) initial level of arm/hand function, as measured by the initial FMA score, (2) time after stroke (subacute versus chronic), (3) concurrent TNR, (4) the amount of gaming time, and (5) sensation. Section 2 was feasible. In a given gaming session run by undergraduate and graduate students, the clinician spent an average of 10 minutes giving instructions and assisting with game selection and modification. Overall, the commercially available game options met the needs of a wide range of deficits after stroke and were highly modifiable. However, it was important that the supervising clinician as well as the students was knowledgeable about the different gaming options. About 50% of the participants needed some hands on assistance from the students during the gaming sessions. Table 2 summarizes the means and standard deviations of the outcome measures. The average score on the FMA increased by 8 points (P = 0.002), which is greater than the 6.6-point MCID [37]. The mean improvement of 11 seconds on the WMFT (P = 0.003) was greater than the 1.5-to 2-second MCID in subacute stroke [39]. There was no statistically significant difference in the two subscales of interest in the SIS : ADL (P = 0.551) and hand function (P = 0.599).

Covariate Analysis.
Several analyses were completed with the primary outcome measures, the FMA and WMFT, to help delineate inclusion criteria for the planned randomized clinical trial (RCT). First, FMA and WMFT results were examined in relation to initial arm function as measured by the FMA scores ( Figure 2). As a result of this analysis and in conjunction with research on return of arm function after stroke [47,48], participants were grouped into four groups. Participants who had initial scores of 10 and lower (no. 1 and 2) did not benefit from the intervention, while most individuals in the other three groups (11-35; 36-55; 56-66) did improve. In order to determine whether time after stroke affected outcomes, participants were grouped into either subacute (3-9 mo post) or chronic (>9 mo post) categories [3] based on when they began the gaming study. Figure 3 shows that while the subacute group made larger gains, the chronic group also improved.
The effect of concurrent upper extremity traditional neuromuscular rehabilitation was examined. All participants were either receiving concurrent occupational therapy (OT) consisting of traditional upper extremity neuromuscular rehabilitation, outpatient physical therapy which focused primarily on the lower extremity neurorehabilitation, balance, and/or aerobic training, or were participating in an exercise class. As seen in Figure 4, while both groups improved, those individuals receiving concurrent upper extremity traditional neuromuscular rehabilitation had greater improvements.
Since the amount of gaming time was self-selected in this pilot project, its affect on the outcomes was examined. Participants were grouped according to minutes of gaming time as follows: 500-999 minutes (56% of participants), 1000-1499 minutes (25% of participants), and 1500 minutes or more (19% of participants). As can be seen in Figure 5, the group who completed the greatest amount of gaming showed the greatest improvement. No significant difference was found between the low and middle gaming time groups.
Finally, Figure 6 illustrates the changes seen in participants presenting with initial sensory dysfunction on the FMA. All but one of the 11 participants showed improvements in sensation at the time of postintervention testing.

Motivation.
Motivation to practice was assessed using the IMI. This was statistically significant (P = 0.001 using the Wilcoxon signed-ranks test) with the mean increasing from 5.3/7 (sd = 1.0) for the home exercise program to 6.4/7 (sd = 0.7) for gaming.

Discussion
In this pilot study, we found that participants were highly engaged in the gaming activities, resulting in improved participation in this voluntary adjunctive intervention. This, in turn, led to the completion of significant quantities of repetitive goal-directed practice at levels rarely obtained in traditional outpatient upper extremity neurorehabilitation [7]. The virtual reality literature discusses the concept of "presence" as a form of positive, active engagement that occurs during the VR experience [49]. Our observations are consistent with work by Rand and colleagues [9] who noted a high sense of presence during gaming for their participants.
It was feasible to use the ENGAGE protocol to provide large quantities of meaningful and engaging practice in a realistic clinical environment. While not formally measured throughout the study, actual practice repetitions varied from only a few per minute for games like golf and bowling to over 50 repetitions per minute in games such as boxing and drumming. The game selection algorithm allowed for preparatory work on impairments and task components as part of a meaningful activity before progressing to practicing the actual task. This may clarify the recent discussion about the effectiveness of upper extremity task practice [50][51][52][53], since we hypothesize that an underappreciated critical component is meaningful and engaged practice rather than  just task specificity. Of additional importance in this small pilot sample is the fact that this intervention resulted in significant changes in motor function for individuals with lower functioning upper extremities (initial FMA upper extremity scores between  in addition to those with higher function, including some hand and wrist movement. These lower functioning individuals would not be candidates for CIT [6]. At present, the primary evidence-based approaches for these individuals are robotics and virtual reality interventions which are typically expensive and not universally available to the clinical community [14,15,54]. The ENGAGE protocol, however, uses inexpensive, commercially available video gaming equipment in a clinically feasible protocol. In our upcoming randomized clinical trial, we plan to include individuals with upper extremity FMA scores of >10 at three months or more after stroke since those with lower motor function did not appear to benefit from the protocol. It is probable that some baseline level of motor function is necessary to actively participate in the gaming intervention. In addition, the single very high functioning individual (initial FMA score of 64/66) did not improve on our motor outcome measures. Therefore, we plan to exclude individuals with FMA scores >63 because few of the games require high levels of dexterity practice to sufficiently challenge such an individual.
Coordinating gaming with simultaneous upper extremity neuromuscular rehabilitation improved outcomes in this pilot study. Thus, our upcoming trial using the ENGAGE Stroke Research and Treatment protocol will include two intervention arms, each with a different percentage of concurrent upper extremity rehabilitation, to better quantify the dosage of skilled versus adjunctive therapy necessary to result in clinically significant changes in motor function. It offers a novel way to use gaming to substantially increase repetitive practice opportunities at a reduced cost compared to conventional practice [7], while remaining highly individualized and targeted.
The ENGAGE protocol was found to be a cost-effective intervention, due in large part to the ability to utilize students and support staff. In addition to the time required to train clinicians and staff, expense of equipment must be considered. We were able to use only two different gaming system platforms, the Wii and PlayStation II, along with six different game discs on the two systems. This provided a wide selection of gaming options, allowing us to meet the needs of individuals at various levels of arm function, to provide variability of practice opportunities, and to prevent the boredom that often occurs when completing one task repetitively. While it was critical for treating clinicians to be familiar with all game options, limiting game selections meant that busy clinicians could learn the different game alternatives in a reasonable amount of time.
Our data analysis revealed several unexpected results. First, we measured upper extremity sensation using the FMA as a potential covariate. We found that 11 out of the 12 participants with sensory loss improved on this section of the FMA postgaming. While we know that sensory function is a critical component in motor learning [55], there is little consensus in our research literature about interventions to improve sensation after stroke [56]. These preliminary results warrant more systematic evaluation of sensory function in our upcoming trial. Second, we hypothesized that the subacute group would improve significantly more than the chronic group. Although this pattern did emerge, the difference was small, supporting the theory that many individuals after stroke with upper extremity dysfunction learn not to use the hemiplegic arm and hand [57] and that at present, we do not provide adequate interventions in this area [7]. Based on these pilot results, we will continue to enroll individuals with both subacute and chronic stroke since both groups demonstrated clinically significant levels of change. In this convenience sample representative of the outpatient population of the two participating facilities, half of the outpatient participants were at least six months after stroke. Finally, the one area where participants did not change was the SIS, which is a reflection of the participant's perception of their function, rather than an actual measure of function [40]. Examining the results of only the subacute group, we measured changes beyond the MCID of 5.9 in the ADL subsection (increased from 58.5 to 71), but not beyond the MCID of 17.8 for the hand subsection (increased from 42 to 44) [41]. This can be explained by the fact that several of these individuals did not regain functional use of the hemiplegic hand. Also, it is hypothesized that individuals in the subacute group may have become more aware of the degree of deficit over time after discharge home. The lack of change in the chronic group is potentially a reflection of a more stable perception in their function during the longer time since the stroke event. This study has a number of limitations. As a pilot clinical outcomes study, there was no control group and no control for concurrent therapy. Additionally, the amount of gaming time was self-selected by each individual participant. These factors will be controlled in our upcoming trial. Dosage questions are unanswered by this study, especially since the 500-999-minute and 1000-1499-minute practice groups made similar gains. The use of gaming time rather than actual practice repetitions may account for this finding, since there is a large variation in repetitions between slowpaced games such as golf and bowling and fast-paced games such as boxing and sword fighting. An accelerometer-based system has been designed as part of this pilot study and will be used in our upcoming trial to quantify the amount of practice required for clinically relevant and functional change [58]. Based on these preliminary data, the protocol for our upcoming trial has been designed to include two intervention arms examining a dosage of one additional hour of gaming for each of twelve weeks, as compared to an hour of TNR. This will provide a total of 720 additional minutes of gaming time or TNR in conjunction with two weekly sessions of TNR. A power analysis has been completed on these preliminary data for this noninferiority hypothesis. A followup testing session one month after completion of the gaming intervention will also be included.
Second, although all raters were trained and used the detailed administration manual developed for the FMA and WMFT, there were multiple evaluators during this study, and interrater reliability was not specifically assessed. The protocol for our upcoming trial includes a blinded evaluator who has been standardized in the administration of the outcome measures to complete all baseline and postintervention testing.
Third, postural stability was not formally assessed in this investigation although improvements were observed that were potentially aided by the gaming intervention. These observations warrant a more systematic evaluation of postural stability in the planned subsequent RCT.
Finally, more objective measures of engagement are needed, as a ceiling effect might have occurred with the IMI. Anecdotally, we, as a group of experienced clinicians, rarely observed a level of engagement in traditional neurologic rehabilitation as witnessed during gaming. We feel the IMI results may have been confounded by the socialization that occurred during gaming but not during home exercise.

Conclusion
In this pilot investigation, we found that the use of ENGAGE protocol was feasible in a clinical environment. There was a statistically significant improvement in upper extremity function as measured by the upper extremity portion of the FMA and by the WMFT, and participants were motivated to use this gaming protocol. Dosage of gaming time remains unclear, but individuals who completed at least 500 minutes of the intervention demonstrated improvements in function. In future work, the ENGAGE protocol will be used as an adjunct to concurrent upper extremity rehabilitation.