Comparison of the Knowledge and Practices in Medicine Dispensing between Retail Medicine Shops and Model Pharmacies in Dhaka Metropolis

Department of Pharmacy, East West University, Dhaka 1212, Bangladesh Palli Karma-Sahayak Foundation (PKSF), Agargaon Administrative Area, Dhaka 1212, Bangladesh Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh Pharmakon Neuroscience Research Network, Dhaka 1207, Bangladesh Department of Public Health, North South University, Bashundhara, Dhaka 1229, Bangladesh Department of Biochemistry and Molecular Biology, Trust University, Barishal, Ruiya, Nobogram Road, Barishal 8200, Bangladesh


Introduction
In Bangladesh, retail medicine shops are specifically licensed outlets in the marketplaces run by regular shopkeepers. Few pharmacists have short training (either A-, B-, or C-grade pharmacist) and from where the clients purchase medicines as and when required. Retail medicine shop or retail pharmacy practice has been characterized as an incomplete or marginal profession by sociologists, and some of its tasks are done through proper judgment and expertise, but others are merely routine and repetitive tasks [1]. To ensure and materialize an effective healthcare system, pharmacists need to be available all the time with their expert opinions on medicines and need to provide basic primary health care (PHC). Hence, deploying the need to set up model medicine shops and pharmacies is essential. Model pharmacies can be defined as developing shops to ensure safe medication dispensing and patient care [2]. As per the guideline by DGDA, model pharmacy (level I) is a level of service that will be provided by an 'A'-grade registered pharmacist (having Bachelor of Pharmacy and Master of Pharmacy Degree with a valid registration number) who will remain present on the premises 24/7 days. 'B' (having a Diploma in Pharmacy) or 'C' (having completion of certificate course and known as professional dispenser) grade pharmacist personnel may assist with dispensing under the supervision of the "A"grade pharmacist. Model medicine shops (level II) provide a level of service carried out by a person having a "C"-grade qualification at a minimum. e staff of model pharmacies must have appropriate skills, qualifications, and competencies and assume liabilities for their tasks as the pharmacist-in-charge. All "A-," "B-," and "C"-grade pharmaceutical personnel working in the model pharmacies must undergo a Pharmacy Council Bangladesh-(PCB-) approved 30-hour orientation (for "A" and "B" grade) or 80 hour dispensing training course ("C" grade) and pass the related examination. e C-grade pharmacist in the retail medicine shops, widely known as salesperson or dispenser, must have 12-week short training to avail a certificate. is certificate course is jointly conducted by the Bangladesh Chemist and Druggist Samity (BCDS) and Bangladesh Pharmaceutical Society (BPS). According to the guideline, the presence of an "A"-grade pharmacist registered by the PCB is a must to keep the business and service open [3]. All these criteria are to ensure rational use of medicines, but unfortunately, the practice is not maintained correctly as per the guideline.
In Bangladesh, unsafe use of medication, purchasing medication without a prescription or not following the prescription, random use of antibiotics, and the hazardously high proportion of antibiotic resistance are essential issues in the healthcare sector that are not appropriately focused [4][5][6][7]. DGDA, Bangladesh, as the sole regulatory body for regulating pharmaceutical industries, is yet to successfully grasping control of the predicament [8]. Emphasized these crises, e National Drug Policy, 2016, has been promulgated by the Government of Bangladesh to ensure rational and harmless use of quality drugs with good dispensing patterns and at an affordable price.
e awareness for establishing model pharmacies was generated following this policy [9,10]. A Tanzania-based "Accredited Drug Dispensing Outlet" model worked as an information source for it. Duka La Dawabaridi (DLDB), a licensed outlet for essential medicines in Tanzania, was found to possess certain limitations in their quality of treatment, scarce storage of drugs, inexpert staff, inadequate management, and enforcement after evaluation in 2001. As a solution to these problems, Management Sciences for Health, an NGO, and advisory organization of the UK, began working with the Government of Tanzania. ey ensured quality medicines and pharmaceutical services at affordable prices [11]. e history behind the establishment of model pharmacies in Bangladesh resembles that of Tanzania. is Tanzania-based Bangladesh model was established with an aim to ensure a drug-selling platform linked to primary health care and a community-level platform associated with effective public health programs. e Accredited Drug Dispensing Outlet (ADDO) model shops were supposed to make sure essential PHC services like knowing first aid for snake biting, drowning, dressing burns and wounds, temperature, blood pressure, and body weight measurement, examining urine sugar, providing DOTS services, and offering health promotion and education [12]. e World Health Organization (WHO) defines rational use of medicine as "when patients receive medications appropriate to their clinical needs, in doses that meet their requirements, for an adequate time, and at affordable prices" [13][14][15]. According to WHO, the dispensing process should have six steps that must be maintained by the pharmacies and to be ensured by the pharmacists [16]. e legal and regulatory framework for community pharmacies in the WHO European Region is to maintain strictly [17]. In several countries, the quality of drugs and inappropriate use of antibiotics is a growing concern [18]. From a public health viewpoint, this situation needs special attention because due to these malpractices mass population becomes more vulnerable to excess healthcare cost, adverse drug reaction, allergic reactions, toxic poisoning, exacerbation or prolongation of critical illness, antibiotic resistance, and most importantly, ineffective and unsafe treatment [19,20]. In Bangladesh, the physicians-to-population ratio were 1 : 3600 in 2011 [21]. is critical scarcity of registered physicians creates a communication gap between physicians and patients. erefore, it scopes for pharmacies to act as a primary intermediary to provide essential solutions to health-related problems.
Moreover, buying any medicines without prescriptions is a common and open secret practice in Bangladesh but not confessed by pharmacy owners. Due to aggressive marketing strategies of pharmaceutical companies [22], the salesperson and dispensers are falling easy prey to this insistent marketing that leads to illegal overprescribing, unnecessary and expensive drug prescribing, dispensing drugs without prescription, overusing antibiotics, and injection dispensing [23][24][25]. In developing countries like Bangladesh, people depend heavily on pharmacies due to practicality, shorter waiting time, cost reduction, availability of credit, and flexible opening hours [26,27]. Hence, this study was carried 2 Advances in Public Health out to assess the effectiveness of newly inaugurated model pharmacies over retail medicines shops in aspects of improving dispensing practices, patterns, and knowledge of both dispensers and clients.

Study Method.
is study was a facility-based (medicine shop-based) cross-sectional pilot study employing a random sampling technique for exploring and comparing existing practice, knowledge, and dispensing patterns of retail medicine shops and model pharmacies.

Study Site.
ere are around 4,447 licensed retail medicine shops and 193 model pharmacies around Dhaka district as per the most recent data of DGDA, Bangladesh [10]. From May 2018 to November 2018, data on dispensing practices and patient's knowledge regarding buying of medicine were randomly collected from the salespeople/ dispensers ("A-," "B-," and "C"-grade pharmacists/chemists/ owners/managers) and clients (patients/customers/purchasers) of 90 retail medicine shops and 90 model pharmacies within the sampling frame of the study.

Study Participants.
A random sampling technique was employed. At least one dispenser/salesperson (chemist/ owners/managers/"A-," "B-," and "C"-grade pharmacist) and one client (patient/purchaser/respondent) from each pharmacy were covered in the study. Of the population size of 90 pharmacies, 25 samples had been discarded because of a lack of full and correct information. Finally, the study was progressed corresponding to 65 samples about dispensers (chemists/owners of the retail medicine shops/managers/ "A-," "B-," and "C"-grade pharmacists).

Questionnaire Design and Data Collection.
ree methods were used to elicit pertinent data using appropriate questionnaire sets. ose are (i) for quantitative data accumulation, structured close-ended questionaries were designed, (ii) for qualitative data accumulation, semistructured open-ended questionaries was designed, (iii) Key Informant Interview (KII) and structured observation were taken as a part of the qualitative exploration for eliciting data about knowledge, perception, and practices of the clients and salesperson of both types of medicine dispensing facilities. Key informant interviews were taken with the respondents who participated in the provider interview method (PIM).

Method Implementation.
Two different methods were employed for data collection: one is a client simulation method [28] and another is the provider interview method [29].

Client Simulation Method (CSM).
Two undergraduate students (both female) were recruited to act as simulated clients and were trained for 30 days, and trial data collection was conducted for another 30 days. ey pretended in such a way that they were engaged in simple talks with the clients who came to buy medicine next to her. To reduce the Hawthrone effect, rapport was built with the customer. After building rapport with that customer, they acted as disguised clients. ey bought antibiotics, sedatives, and sex-stimulating drugs without prescriptions from both the retail medicine shops and model pharmacies, and the medicines were discarded later safely. ey also observe the role of pharmacists, dispensers, managers, owners, and the pharmacy personnel are unaware and blinded to the client's research agenda. erefore, information accumulated by this method is considered precisely reflecting typical performance. is will remove any biases induced by any intervention methods. is method provides high quality of data generation by accurate observations.
In this study, the trained two simulated clients presented in the pharmacies either were asking for some prescription medicine (such as sedatives, antibiotics, cardiovascular drugs, and sex stimulants) without showing prescriptions and seeking various advice from dispensers from each pharmacy ( Table 1). For this purpose, a scenario was developed realistically as much as possible using the Bengali language. Later, the scripts were translated into English (1). e simulated clients were instructed to record the whole encounter in a standardized and pretested observation within 20 minutes from leaving the pharmacy. Two simulated clients were used to accumulate all observational data and avoid the biases which are likely to arise in the data collection process. Simulated clients were instructed to buy a small number of prescribed medicines from both retail and model pharmacies and later discarded them safely. A similar session was conducted with one customer who came to the pharmacy to buy medicine for him or his family members.

Provider Interview Method (PIM).
e provider interview method was applied to the same retail medicine shops and model pharmacies after five days. In this method, the interviewers collected data from clients (different) and dispensers (same) as researchers. ey made the participants fill out the structured and semistructured questionnaires following KII and the structured observations method. Separate questionnaires were prepared for the dispensers, and clients came to buy medicines.
2.6. Statistical Analysis. All the data had been compiled and analyzed for comparison using total numbers and percentages. GraphPad Prism (version 4.0) computer program (GraphPad Software, San Diego, CA, USA) was used for ttest assuming sampling from a Gaussian population. Twotailed p value was recommended for determining significance after the comparison of two sets of data. Results were significant when p values were less than 0.0001 (p < 0.0001).

Consent of Participants.
Oral consent was taken from all participants who participated in this study except the respondent of client simulation methods (CSM) ( Table 6). Table 1: Scenarios of medicine dispensing pattern presented by two simulated clients both in retail medicine shops and model pharmacies.

Advances in Public Health
Scenario: buying various prescription medicines without prescription by the 1st simulated client e 1st simulated client was a 21 year-old unmarried female buying medicine for his father for various complications. e medications include antibiotics, cardiovascular drugs, sex stimulants, and psychotic drugs. She speaks Bengali and follows the following scripts. (Start) I would like to buy these medicines for my father en, she presented a written paper with all medicine names in a small amount. e paper is not a prescription; the client waited for dispensers' responses and expecting answers to some questions that provide information which are shown in Tables 2-5 en, the simulated client was waiting for further response from the dispenser to collect all medicines and observed the dispensing pattern of other pharmacists selling drugs with or without prescriptions. She also asked the dispenser about dosage regimen, storage conditions, and ingestion criteria of medicines (described in Tables 2-5) Afterward, the 2nd simulated client started observing how pharmacists provide information on selling medicines to other customers who came to buy drugs (Start) Excuse me; I have come here to buy some medicine for my father; probably you too came here to buy some medication; which drug are you going to buy? After getting a response from a nearby customer, the 2nd simulation client tried to collect her desired information from customers. She also observed whether the customers were seeking a pharmacist for advice regarding health complications, and an "A"-grade pharmacist was present in the pharmacy at that time Both 1st and 2nd simulated clients asked some questions which are described separately in Tables 2-5. ose questions are preassigned

Quantitative Findings.
Clients and dispensers filled up structured close-ended questionnaires in both retail medicine shops and model pharmacies that helped gather quantitative findings. is survey was focused on comparing different factors such as the demographic characteristics of the clients and the dispensers (pharmacists), prescription pattern, quality of health care provided, patient's safety, retailer's knowledge, clients' satisfaction, and dispensing practice in both retail medicine shop and model pharmacy. Table 7 revealed demographic features such as gender, age, educational and financial status, marital status of dispensers (pharmacists/ chemists, n � 65), and customers (n � 90) obtained by the provider interview method. No demographic data were collected for client simulation methods. In the retail medicine shops, 100% of retailers were male, whereas only 6% were female pharmacists in model pharmacies. To assess the educational qualification, it was observed that 49% of clients  in the model pharmacy were graduates, whereas in the retail medicine shop, the percentage is 21. Surprisingly, clients (96%) who came to the model pharmacies had almost no clear concept about the services of model pharmacy. It was observed that the highest percentage (33% and 50%, respectively) of middle-middle class customers went to both retail medicine shops and model pharmacies ( Table 7). According to these study findings (Table 2) on the report of CSM, there was no A-grade pharmacist in the retail medicine shops, except 9% B-grade and 91% C-grade pharmacists were present there. But in model pharmacies, 63% A-grade, 5% B-grade, and 32% C-grade pharmacists were present. Observation stated by PIM that 81% of dispensers in retail medicine shops were C-grade pharmacists, and in model pharmacies, 69% of pharmacists were A-grade pharmacists. Among 130 dispensers (A-, B-, and C-grade pharmacists/chemists/owners/ managers) from both retail medicine shops and model pharmacies (Table 3), 86% of dispensers of retail medicine shop and 100% dispenser (A-, B-, and C-grade pharmacist/chemist) of model pharmacy knew about the difference between OTC drug and prescription drug as per PIM, whereas in actual 54% of dispensers of retail medicine shops and 88% of model pharmacists knew about the difference according to CSM (p < 0.0001). 88% dispenser (retailer/salespeople) of retail medicine shop and 100% dispenser (A-, B-, and C-grade pharmacist/chemist) of model pharmacy reported that they informed clients about the mode of medicine administration during data collection by PIM. But the actual percentage was only 23% in retail medicine shops, and 69% in model pharmacy advised clients about the administration of medicine as observed by CSM (p < 0.0001). It was also observed that merely 21% of dispensers in retail medicine shops informed clients about side effects.
In contrast, according to the provider interview method, 88% of dispensers claimed that they told the customers about the side effects of the drug (Table 3). Surprisingly, only 12% of dispensers in retail medicine shops and 32% of dispensers in model pharmacies informed customers about the toxic effect of drugs, according to CSM. Yet, the actual percentage is much higher (74% and 94%, respectively) according to PIM. On the other hand, 11% of dispensers in model pharmacies and 37% of dispensers in retail medicine shops confessed that they sold medicines informing customers of the side effects of drugs (except OTC), according to PIM. But, astonishingly, 95% of salespersons in retail medicine shops and 77% in model pharmacies sold drugs (except OTC) without prescription (Table 3).
Customers were asked whether they had any idea about the functions of model pharmacies and retail medicine shops; According to PIM, nearly 2% of retail medicine shops and 48% of the customer of models' pharmacies claimed that they had an idea about them. According to CSM, the percentage is 3 and 10 in retail medicine shops and model pharmacies, respectively (Table 4). According to PIM, customers of retail medicine shops and model pharmacies said that 64% and 76% went to intake medicine after consultation with a doctor on average. But in CSM, the percentage was changed dramatically as only 18% of retail medicine shops and 37% of the customer of model pharmacies went to intake medicine after consultation with a doctor (p < 0.0001). According to CSM, only 49% and 57% of customers came to retail medicine shops and model pharmacies, respectively, which had good storage facilities. According to CSM, 63% of customers in retail medicine shops bought antibiotics and sedatives without prescription, and only 60% completed the entire course of antibiotics or any other prescription medicines. Still, in model pharmacies and retail medicine shops, 54% and 49% generally did these aberrant practices, respectively. According to PIM, 22% of the retail medicine shops and 28% of customers of model pharmacies know the differences between OTC and prescription medicine. An observation pointed out by CSM in both categories of pharmacy revealing that only 34% of customers knew the differences (Table 4). Table 5 was designed based on finding that 24 out of 65 dispensers in retail medicine shops traded prescription medicines without a prescription, according to PIM. In contrast, in the case of model pharmacies, only seven dispensers did the practices. On the flip side, 62 out of 65 in retail medicine shops and 50 out of 65 dispensers in model pharmacies barter previous prescription medicine without any new prescription, according to CSM. Hinge on this fact, Table 5 was formulated to determine the underlying reasons for trading previous prescription medicines without a new prescription by the dispensers/retailers/salespersons. Additionally, an attempt was made to find the factors influencing customers to go for this intake medicine and ways of intake and purchasing medication without doctor's advice. In PIM, 42% of dispenser/salesperson of the retail medicine shop and 43% of model pharmacy said that they sold drugs without a prescription to meet patients' basic needs. In CSM, 52% of dispenser/salesperson of retail medicine shops said that they sold drugs without prescription for meeting ondemand instant needs of the clients, 3% for the negligence of legislation, and 11% for financial purposes. e rest, 34% dispenser/salesperson of retail medicine shop and 100% dispenser/salesperson of model pharmacy, said they sold drugs for all the above reasons (basic need, negligence of legislation, and financial purpose) ( Table 5). e customers Table 6: Inclusion and exclusion criteria for the selection of the participants.

Inclusion Criteria
Exclusion Criteria Adults ≥18 years of age Participants having mental disability All participants regardless of sex, socioeconomic status, and education Participants who are too sick and came to pharmacies for health care services Ethnicity Owners of pharmacies who did not have any A-/B-/C-grade pharmacist certification/ owners of pharmacies having no health care education 6 Advances in Public Health were also asked for ways of taking medicine without the doctor's suggestions. In commensurate with finding by PIM, 20% of customers bought medicine by own opinion (n � 18), 1% by previous prescription (n � 1), and 15% by the dispensers' (retailers/salespersons) suggestions in retail medicine shops (n � 13). On the other hand, 9% of customers (n � 8) in model pharmacies responded that they ingested medicine by their own opinion, 2% by previous prescription (n � 2), and 13% by dispensers' (retailers/salesperson) suggestions (n � 12). According to CSM, 2% customers of model pharmacies took medicine by their own opinion (n � 2), 21% following previous prescription (n � 19) and 40% by the dispensers' (pharmacists'/chemists) suggestion (n � 36). e customers were questioned regarding the reasons for taking the medication without a doctor's suggestion. About 7% of retail medicine shops (n � 6) and 3% of customers (n � 3) of model pharmacy acceded to it for financial reasons. Additionally, 10% of clients of retail medicine shops (n � 9) and 6% of clients of model pharmacy (n � 5) used to follow the previous prescription. But in the case of CSM, it was seen that 17% of clients of retail medicine shops (n � 15) and 22% clients of model pharmacy (n � 20) were buying it for the reason of financial burdens, and 32% clients of local medicine shop (n � 29) and 21% clients of model pharmacy (n � 19) agreed for using the previous prescription (Table 5). e qualitative findings acquired from key informant interview (KII) and structured observation are encapsulated as follows.

Qualitative Findings Based on Knowledge and Dispensing Scenario in Direct Conversation with Client and
Dispenser. All of clients and dispensers participated in semistructured open-ended questionaries, key informant interviews (KII), and structured observations, which were the methods of gathering information from both retail medicine shops and model pharmacies by PIM only.
Most clients were not aware of model pharmacy. ey did not understand functional differences between retail medicine shop and model pharmacy, and even they had no preferences to choose between them: "I did not hear the term "Model Pharmacy" before. Today I have just heard it from you. To me, all medicine shops are the same, and I buy medicine from any medicine shops nearer to my home as per convenience. I do not know which one is the model pharmacy and which one is the retail medicine shop." A few customers have a slight idea about model pharmacy, which was not for its excellent service but infrastructure. A client of model pharmacy echoed such a perception that almost reflects the same tone of others: "In my locality, this pharmacy (a model pharmacy) is quite large, has the air-conditioning facility, and I get all kinds of medicines here. at is why I very often go here. I think all "I know about model pharmacy, but the services model pharmacies are supposed to provide are absent. ey do not provide primary health care services and patients consultation services as and when dedicatedly needed".
During the qualitative study, the dispensers (A-, B-, or C-grade pharmacists/chemists/owners/managers/salespeople/retailers) mentioned many limitations causing model pharmacies not to ensure effective patient services.
Many owners of the model pharmacies pointed out the training related limitation conducted by PCB and legislation-related issues of DGDA: "We accepted the scheme of model pharmacy, renovated and enlarged facility according to the core requirements of it, but we did not get any technical or monetary incentives from the regulatory bodies or and they did not offer any dispensing training of our existing dispensing staffs." Amid 65 dispensers, 46 dispensers talked so much about the monetary benefits of model pharmacy. An owner remarked when interviewing as follows: "From the very beginning, the concept of model pharmacy should have been backed by Private-Public Partnership (PPP) business with such an arrangement in which honorarium of the "A" grade pharmacist will be provided by the govt and honorarium of other dispensing staffs is to be given by the owner. It is not possible for a model pharmacy to bear all the costs incurred, and therefore, we hardly make any profit".
Another issue raised mainly by a significant number of the owners/managers of the model pharmacy is insufficient knowledge for counseling patients and monitoring dispensing process done by the appointed "A"-grade pharmacist: "I think both DGDA and PCB authority need to train "A" grade pharmacists professionally. In my opinion, they have limitations of knowledge for patients counseling. I am emphasizing this issue and ask to review the existing Bachelor of Pharmacy syllabus for modification".
On the other hand, 51 retailers amongst 65 retail medicine shops made their own opinion close to the same tone: "I do not think those Model pharmacies are providing much better services than us. ey also dispense medicines without prescriptions as we are. You know we have several limitations, and most often, we sell medicine without prescriptions".
More than 70% appointed "A"-grade pharmacists in model pharmacies expressed their job dissatisfaction, talked on low honorarium issue, and prolonged service hours as follows: "As an "A" grade pharmacist, we do not have any specific job responsibility. e owners of the model pharmacies generally fix up our salary ranging from 10 000 BDT to 50,000 BDT (118 USD to 590 USD) based on job experiences. ey also forced a pharmacist to do his job from 9 am to 12.00 midnight within that salary range without paying for overtime. Sometimes they also compelled us to do their other works which is not related to dispensing or counseling patients".
Almost all owners or managers of model pharmacies expressed difference of opinion about the knowledge-based dispensing and patients counseling performances done by "A"-grade pharmacists: "If I tell you frankly, "A" grade pharmacists need more training on knowledge-based dispensing and patients counseling, the staff, without any degree working in my institutions for a long time, is more efficient in dispensing and patients counseling. So, in terms of making a profit and ensuring good dispensing and counseling performances, this issue is sure does matter to us before recruiting an "A" grade pharmacist".
On the other hand, 90% of "A"-grade pharmacists claimed on formulating a strict profession-based regulation by DGDA: " e DGDA and other concerned authorities should provide a strict guideline, and monitoring system about the job responsibilities and job security of the recently appointed "A" grade pharmacists, so that the owners of model pharmacies cannot be willful to terminate us from the job now and then. is is very disrespectful to us".
Many "A"-grade pharmacists mentioned the lack of moral status in the job and insufficient logistic support to render good services to the patients. An "A"-grade pharmacist remarked as follows: " e owner of the model pharmacy most often compelled us to dispense medicine only in the front counter, which is not my job responsibilities. We do not have suitable setting arrangements and logistics both for the patients and us; even we do not have any separate counseling space for keeping patients' privacy. We almost remain standing in whole working hours at the counter to sell medicine".

Discussion
In Bangladesh, the model pharmacy was first launched in 2016 based on the ADDO model shop of Tanzania. e aim 8 Advances in Public Health of establishing a model pharmacy was to ensure safe and proper dispensing of medicine, stop the divergent practices of dispensing prescription medicine, and ensure knowledge for both clients and dispensers associated with systemic use of medication and related risk of nonproper use of medicine. After two years of the inauguration of model pharmacy, this study was designed to analyze and compare the effectiveness of drug dispensing patterns, practices, and knowledge of both clients and dispensers of model pharmacies over traditional retail medicine shops. According to this fact-finding study, the presence of an "A"-grade pharmacist was below 70%, which was supposed to be 100%. Moreover, knowledge and practice-based counseling of the clients by dispensers of model pharmacies (A-, B-, or C-grade pharmacists/chemists/salespeople) were not found satisfactory and substandard practices were reported. Only a few clients have a rudimentary idea about model pharmacies. e clients also had substandard medicine buying, administration, and storage practices in model pharmacies and retail medicine shops. e pharmaceutical market in Bangladesh is expanding [30], and self-medication has become a rising problem. e retailers/salesperson (who could be an A-, B-, or C-grade pharmacists/chemist/owner of the shops/manager of the shop) are playing a crucial role in fostering self-medication. e problem is also in the hike as self-medication reduces the cost of physician's consultancy and diagnostic tests [31,32]. e rapid and continuous access to mobile phones and Internet also contributes to this practice [30]. It has also been noticed that the retailers, pharmacists, and their assistants are also not following the guidelines of model pharmacy [33], which affects extensively the irrational dispensing of medicines [30]. In this study, a holistic approach has been taken to check for the quality of drugdispensing practices in both types of pharmacies. Ethical drug dispensing is an integral part of rational therapy of drugs [8,9,[33][34][35][36][37].
is study revealed that female participation both in retail medicine shop and model pharmacy as a pharmacist is rare. But as a customer, no significant differences in buying medicine were noticed.
In both categories of pharmacies, this was spotted that people aged 30 to 49 bought the highest percentage of medicine. It was also revealed that customers/patients having secondary education and graduation degrees bought more medication. Marital status did not relate to any contributory findings. Financial condition showed middle-middle class people tend to collect the lofty number of drugs ( Table 7). As mentioned in this study (Table 2), it manifested that retail medicine shops run by only "C"-grade pharmacists (81%), and model pharmacies have the dominant presence of A-grade pharmacists (69%), according to PIM. Still, the actual scenario is disappointing as per CSM, 91% of pharmacists are working as "C" grade in local pharmacies with no (0%) "A" grade, and only 63% was "A"-grade pharmacist in model pharmacies, and 32% was "C" grade. ese findings revealed model pharmacies are not following appropriate guidelines set by DGDA, and indeed, that is an indication of poor practices of medicine dispensing. According to Table 3, observation relating to the role of pharmacists and chemists in both model and local pharmacies exhibited ignorance in serving patients. Only 69% of pharmacists of model pharmacies informed customers about medicine administration procedures, 32% informed about toxicity, and 77% sold medicines (except OTC) without prescription in conformity to CSM. ese provide evidence of poor implementation of proper dispensing practices of model pharmacies.
is also violates the aim and necessity of establishing model pharmacies to ensure good medicine dispensing practices among customers.
According to the doctor's advice, in conformity to CSM, regarding output from the customers from both model pharmacies and retail medicine shops, merely 37% of model pharmacies delivered intake medicine. Surprisingly, 63% of buyers could buy medicine from the model pharmacy without any direction from a doctor, 57% of customers were merely informed about storage conditions, and 54% of customers could buy antibiotics and sedatives without prescription in model pharmacies (Table 4). ese depict inadequate monitoring and insufficient practices regarding proper medicine dispensing practices of model pharmacies. Moreover, only 49% of customers confessed that they completed the entire course of antibiotics, which in turn indicated 51% of buyers did not fill up the whole course of antibiotics. ese crucial findings depicted an inferior pictorial view of model pharmacies on the aspects of patient awareness and counseling. Table 5 represents underlying reasons for selling and buying medicines without a prescription. Almost all pharmacists of model pharmacies (50 out of 65), according to CSM, sell medicine without prescription for the reason of meeting the basic need of customers, negligence of legislation, and for financial purpose. But according to PIM, only 7 out of 65 pharmacies revealed the truth that they sell medicine for the abovementioned reasons. In addition, according to CSM, in model pharmacies, 57 customers out of 90 bought medicine according to their own opinion, previous prescription, and pharmacist's suggestions.
All these findings revealed a minimal substandard medicine dispensing pattern of model pharmacies. is study found partial validation that model pharmacies follow the standards set by DGDA in comparison with the retail medicine shops. No significant differences were found/noticed both in model pharmacies regarding proper medicine dispensing and patients counseling. Similar studies were conducted in Japan, Ethiopia, India, Zimbabwe, Sudan, Tanzania, Pakistan, Laos, ailand, and Vietnam [31,[38][39][40][41][42][43][44][45]. Noteworthy differences were found regarding dispensers' knowledge of drugs' side effects, informing patients about the side effects, selling drugs (except OTC) without prescription, etc., among the model pharmacies and retail medicine retail according to CSM. All these are very important for proper drug dispensing [35]. Often customers' constant pressure does not let the pharmacists talk to them about drug administration, side effects, etc., at the peak hours [46]. Patients' ignorance about their therapies also contributes to irrational drug use, especially when they are poorly educated and try to reduce treatment-related expenditure by not paying a visit to the doctor and taking self-medications. Patients often cannot remember the names and doses of medicine, use leftover, date-expired drugs, and go severe during chronic Advances in Public Health diseases such as asthma, cardiac disease, rheumatoid arthritis, and osteoarthritis [47][48][49][50][51][52].
On the other hand, qualitative findings obtained from the PIM method revealed several barriers to ensure effective client/patient counseling and knowledge of good dispensing practices. Engaging KII, semistructured questionnaires, structured observation methods as qualitative data collection tools disclosed about lack of dispensing and patients' counseling knowledge of "A" grade pharmacists, their prolonged office hour, job insecurity, substandard job environment, lack of dispensing training, and marginal salary range. Oppositely, the owners or managers of model pharmacies are disaffected by lack of dispensing training, shortfall of professional experiences of "A"-grade pharmacists, and nonadherent attitude of DGDA to monitor and regulate legislation properly for ensuring good dispensing knowledge, pattern, and practices of model pharmacies of retail medicine shops.
It can be deduced from the observation that purchasers are not aware of model pharmacies established in and around Dhaka city.
is observation also reflected that DGDA, the regulatory body of Bangladesh, could not take any intervention-based measurement yet to pull proper attention of patients/purchasers or mass population regarding medicine purchase and to face difficulties to ensure healthcare services for patients or customers. For these reasons, as a pilot project, the model pharmacy was launched. According to good dispensing practices, the model pharmacy needs to follow the standards for creating and delivering good health care services. Otherwise, this pilot project may not be appreciated in the long run. e authority should take more initiatives regarding patient care services, healthcare services, and advertising to benefit model pharmacy to the masses.

Statement of Limitation
(1) e study has been done only within Dhaka Metropolis rather than country wide. (2) Regardless of their socioeconomic conditions, education, and age, the participants have little idea about model pharmacy and the services it provides. So, few data had been discarded due to vague understandability. (3) Owners of some of both model pharmacies and local pharmacies were reluctant to provide pieces of information.

Conclusion
Standard dispensing practices of medicines and proper counseling of customers to ensure good health care practices done by existing model pharmacies are not found in this study. Better monitoring by the regulatory authorities, public awareness campaigns, implementing behavior change communication (BCC), dispersing information education and communication (IEC) materials, a higher degree of professionalism of pharmacists, technical training of dispensers, and close surveillance by the DGDA are necessarily needed to improve the services of model pharmacies. All these combined efforts will ensure the necessity, existence, continuation, and expansion of model pharmacies in the health care system in Bangladesh.

Abbreviations
CSM: Client simulated method PIM: Provider interview method OTC: Over-the-counter DGDA: Directorate general of drug administration PHC: Primary health care PCB: Pharmacy council of Bangladesh BCDS: Bangladesh chemist and druggists samity BPS: Bangladesh pharmaceutical society DLDB: Duka la dawabaridi ADDO: Accredited drug dispensing outlet WHO: World Health Organization BCC: Behavior change communication IEC: Information education and communication.

Data Availability
All data are within the manuscript; a set of questionnaires is available upon request.

Consent
is study is noninvasive, respondent consent was taken, and personal and data confidentiality was maintained throughout the study protocol.

Conflicts of Interest
e authors declare no conflicts of interest.

Authors' Contributions
is work was carried out in collaboration with all authors. All the authors read and approved the final manuscript. Ms. Marium Begum, Sanzana Fareen Rivu, and Md. Ziauddin Iqbal contributed equally to this work. Mst Marium Begum and Md. Sohanur Rahman contributed equally and shared the correspondence.