BioMed Research International

Volume 2014 (2014), Article ID 386742, 3 pages

http://dx.doi.org/10.1155/2014/386742

Erratum

Erratum to “Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells”

Young-Man Lee,¹ Q-Schick Auh,² Deok-Won Lee,³ Jun-Yeol Kim,¹ Ha-Jin Jung,¹ Seung-Ho Lee,⁴ and Eun-Cheol Kim¹

¹Department of Maxillofacial Tissue Regeneration and Research Center for Tooth & Periodontal Regeneration, School of Dentistry, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

²Department of Oral Medicine, School of Dentistry, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

³Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

⁴College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea

Received 1 May 2014; Accepted 20 May 2014; Published 14 July 2014

Copyright © 2014 Young-Man Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

In the original paper, there were a number of errors in Figures 4 and 7. Here, we provide the right form of these figures. In Figure 4(a), p-JNK panels were the same in the HN4 and HN12 cells. In Figure 4(d), vertical, light streaks were included in the p-JNK panel of HN4 during the scanning of X-ray film. In Figure 7(c), vertical, light streaks were included in the NF-B p65 nuclear panel of HN4 during the scanning of X-ray film.

Figure 4: Effect of mollugin on phosphorylation of MAPK (a), activation of Nrf2 (b), and expression of HO-1 (c) in OSCCs. Effects of MAP kinase inhibitors on mollugin-induced activation of NF-B, Nrf2, and HO-1 (d). Cells were treated with 40 μM mollugin for indicated times (a)–(c). Cells were pretreated with the p38 inhibitor SB203580 (20 μM/L), the ERK inhibitor PD98059 (20 μM/L), or the JNK inhibitor SP600125 (20 μM/L) for 1 hour and treated with 40 μM mollugin for 30 min (MAPK, Nrf2, and NF-B) or 3 days (HO-1). The results are representative of three independent experiments.

Figure 7: Effect of Nrf2 siRNA on mollugin-induced growth inhibition (a), apoptosis (b), and apoptosis-related proteins expression (c). Cells were treated with 40 μM mollugin for indicated times (a). Cells were pretreated with Nrf2 siRNA (250 nM) for 5 h and treated for 3 days with mollugin 40 μM (a–c). Statistically significant difference as compared to control, . #Statistically significant difference as compared to mollugin, . Data are representative of 3 independent experiments.