BioMed Research International
Volume 2019 (2019), Article ID 3176951, 9 pages
https://doi.org/10.1155/2019/3176951

Research Article

Attitude of Jordanian Physicians toward Biochemistry and Genetics

Mahmoud A. Alfaqih,¹ Yousef S. Khader,² Nabil Bashir,¹ Zuhair Nusair,³ Quteiba Nuseir,³ and Mohamad Nusier¹

¹Department of Physiology and Biochemistry, Jordan University of Science and Technology, Irbid 22110, Jordan
²Department of Community Medicine and Public Health, Jordan University of Science and Technology, Irbid 22110, Jordan
³Irbid Military Hospital, Royal Medical Services, Irbid, Jordan

Correspondence should be addressed to Mahmoud A. Alfaqih; maalfaqih@just.edu.jo

Received 31 August 2019; Revised 8 October 2019; Accepted 18 October 2019; Published 13 November 2019

Academic Editor: Brad Upham

Copyright © 2019 Mahmoud A. Alfaqih et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Background. Several studies found that physicians develop a negative attitude toward biochemistry and genetics disciplines. Many medical schools adopt an integrated system-based curriculum supplemented with clinical correlations. Medical schools in Jordan switched to the integrated curriculum; however, studies that evaluate the attitude of physicians toward biochemistry and genetics are lacking. Objectives. This study aimed to evaluate the attitude of physicians toward biochemistry and genetics including the correlation of their curricula with clinical practice. Materials and Methods. A structured questionnaire consisting of 40 statements was distributed to a random sample of 616 physicians practicing in private and governmental hospitals in Jordan. Participants earned their MD or MBBS degree from Jordan or other countries and were interns, residents, or specialists. Results. More than half of the participants admitted that biochemistry and genetics are intellectually challenging and were among their least favourite subjects (59.1%); however, many of them were familiar with some of the contemporary advances in biochemistry and genetics and their translational potential (64.0%). Most of the participants felt that modifying the medical school curriculum by integrating biochemical and genetic concepts with clinical teaching will motivate the medical students (74%). In univariate analysis, residents showed the most positive attitudes and were the most knowledgeable about the biochemical changes associated with diseases and about the contemporary advances in biochemistry or genetics (). In multivariate analysis, physicians practicing in the private sector or those with more than five years of experience generally had a more positive attitude toward biochemistry and genetics (). Conclusion. Physicians in Jordan showed an overall positive attitude toward biochemistry and genetics. This was more evident among residents, physicians with more than five years of experience, or those practicing in the private sector.

1. Introduction

Biochemistry and genetics are an integral part of the medical school curriculum [1]. These basic medical sciences attempt to explain the activity of living systems at the molecular level including an understanding of various metabolic and signalling pathways operating within the cells during different environmental and health/disease conditions [1]. Such an understanding is essential for elucidating the underlying mechanisms of multiple disease processes. Furthermore, this knowledge could be utilized for the development of new therapeutic interventions and the discovery of novel biomarkers that aid in the early detection of diseases and/or monitoring their progression [2]. Moreover, with the introduction of next-generation sequencing and the recent advances in gene therapy, these two fields are already playing an even more important role in modern medicine [3]. Indeed, previously abstract concepts like personalized medicine and pharmacogenetics are becoming a part of routine clinical practice [4].

Unfortunately, despite the importance of having a solid foundation in biochemistry and genetics for clinical practice, multiple studies demonstrated that a significant proportion of general medical practitioners have deficiencies in their knowledge on the above disciplines [5–7]. Multiple reasons were put forward to explain this observation: (a) the tedious and unengaging instruction methodology adopted in medical schools [8], (b) the biochemistry and genetics syllabi which are saturated with factual data and abstract concepts [9], and (c) the incorrect notion held by many medical school graduates that the concepts taught in biochemistry and genetics are irrelevant to medical practice [10]. Collectively, all these lead sometimes to a negative attitude toward biochemistry and genetics disciplines among medical school graduates. Interestingly, however, it appears that the negative perception among physicians changes after obtaining their first medical degree; indeed, some studies showed that physicians gain more interest toward biochemistry and genetics after graduation [11, 12]. This is, however, accompanied by a general feeling that their knowledge base in biochemistry and genetics could have been more adequate [11]. This finding lends support to the argument that the attitude of physicians toward biochemistry and genetics could become more positive if the teaching methods of biochemistry and genetics have a better correlation with the following clinical teaching years and postgraduation practice/research [13].

In Jordan, a mandatory degree in premed school is not a prerequisite for admission. Medical students start their 6-year-long degree directly after secondary school [14, 15]. In the medical school curriculum, the core concepts of biochemistry and genetics are introduced during the first and second years as independent subjects [14, 15]. However, during the second semester of the second year and the entire third year, these subjects are taught as part of a modular system-based curriculum where each module covers only one organ system. Notably, this curriculum has only been implemented since 1999, and before that date, the biochemistry and genetics courses were solely taught as independent subjects over the course of the first three years [14, 15]. This entails that physicians currently practicing in Jordan have received their biochemistry and genetics courses using either the older traditional curriculum or the more recent modular-based syllabus. Additionally, current estimates indicate that around 20% of physicians in Jordan have received their MD or MBBS degree from foreign medical schools [16]. Given the above profile, physicians in Jordan represent a unique blend exposed to different teaching styles in basic medical sciences depending on the year, or country of their graduation with an MD or MBBS degree.

Despite the differences explained above in how Jordanian physicians received their biochemistry and genetics courses and the known dichotomy in how physicians perceive these disciplines, there are no studies that investigate the attitude of Jordanian physicians toward these fields. Given the above deficiency, this study aimed to assess the knowledge and the attitude of physicians of various professional levels and backgrounds toward the contemporary advances in biochemistry and genetics. This study also aimed to evaluate the content of the biochemistry and genetics curricula offered in Jordanian medical schools including their correlation with clinical practice.

2. Materials and Methods

2.1. Study Design

This study is cross-sectional in design. Following appropriate ethical approvals and funding from the Deanship of Research at JUST (368/2016), the Jordan Medical Association database was queried for interns (physicians enrolled in a mandatory one-year training program following their graduation) and for residents and specialists from each of the following disciplines: gynaecology, paediatrics, endocrinology, and internal medicine. Using the above database, a simple random sample of 710 physicians (interns, residents, and specialists) practicing in northern, central, and southern Jordan was identified by their ID registration numbers. From this list, 616 physicians were invited to participate in this study based on the following criteria: (a) obtaining the first medical degree (MD or MBBS) between the years of 1985 and 2016 and (b) not sitting for advanced biochemistry or genetics (molecular, biochemical, or cytogenetics) training following graduation including graduate degrees (diplomas, MSc, and PhD), board certifications, or continuing medical education (CME) courses of more than six credit hours. To complete the survey, participants were interviewed face to face by two residents from the public health residency program at King Abdullah University Hospital (KAUH), Irbid, during the period from January to July 2016. Prior to completing the survey, the purpose of the study was explained to the participants who then signed a consent form attached to the frontal page of the survey. Five hundred and fourteen physicians (response rate 83%) completed the survey. The invited physicians who did not complete the survey listed their fully occupied schedule or a general lack of interest in the topic as their main reasons. Unfortunately, most physicians who did not complete the survey were from Southern Jordan; we thus excluded this geographic location from the final analysis (Table 1).

Table 1: Sociodemographic characteristics of the participants.

Interns, N (%)
Residents, N (%)
Specialists, N (%)

Location

Northern
139 (84.2)
210 (76.6)
50 (68.5)

Central
26 (15.8)
64 (23.4)
23 (31.5)

Country of MD or MBBS

Jordan
149 (90.3)
243 (88.7)
50 (69.4)

Others
16 (9.7)
31 (11.3)
22 (30.6)

Employment sector

Private
0 (0.0)
49 (17.9)
2 (2.7)

Public
165 (100.0)
225 (82.1)
71 (97.3)

Public hospital affiliation

Royal Medical Services
48 (29.1)
62 (27.6)
58 (81.7)

Ministry of Health
117 (70.9)
163 (72.4)
13 (18.3)

Data are presented as numbers and percentages.

2.2. Study Questionnaire

A structured questionnaire was designed to include 40 statements. The questionnaire was divided into four sections. The four sections were intended to assess the physician’s attitude and viewpoints toward the following areas: (a) the integration of biochemistry and genetics concepts into clinical practice (Table 2), (b) contemporary advances in molecular medicine (Table 3), (c) the need for continuous education in biochemistry and genetics (Table 4), and (d) the current level of knowledge on biochemistry and genetics among the medical students (Table 5). Questions in each section were drafted by graduate students and were later modified by three faculty members of the Department of Physiology and Biochemistry at Jordan University of Science and Technology each in their area of expertise. The survey was reviewed and modified for clarity, content, and ethical considerations by a senior statistician. A pilot study on 82 subjects was first carried out at KAUH to test the survey methods, and to assess the clarity of the questionnaire. Based on the pilot study, the questionnaire was revised accordingly.

Table 2: Attitudes and perceptions of Jordanian physicians toward the integration of biochemistry and genetics into clinical practice.

Statement
Interns (agree)
Residents (agree)
Specialists (agree)
Total
value

N
%
N
%
N
%
N
%

I employ different biochemical and genetic tests to help reach the correct diagnosis and in following up the patients
145
89.0
247
90.5
64
88.9
456
89.8
0.291

I understand how important biochemical and genetic markers are in detecting the early stages of certain diseases including cancer, hepatic and renal dysfunction, and myocardial infarction
144
87.3
250
91.2
63
86.3
457
89.3
0.287

I understand that subtle biochemical changes precede, in most cases, the physical signs of certain diseases
136
84.0
212
77.9
60
82.2
408
80.6
0.182

I constantly emphasize to my patients the importance of a healthy diet comprising balanced fractions of macro- and micronutrients (including vitamins and trace minerals)
129
79.6
235
86.1
59
80.8
423
83.4
0.011

I am knowledgeable about the biochemical changes that result from hormonal imbalance
128
78.5
231
85.2
54
74.0
413
81.7
0.045

A comprehensive treatment strategy should ideally be directed toward correcting the molecular basis of the disease, if possible, rather than the sole management of the resulting signs and symptoms
120
74.1
228
84.1
64
87.7
412
81.7
0.022

I am familiar with some of the acidosis and alkalosis disease conditions that are best understood and managed in the relevant biochemical context
111
68.1
217
79.8
53
72.6
381
75.4
0.022

I consult with a clinical biochemist on a regular basis to reach my diagnosis and to follow up the patients after they receive treatment
65
40.4
120
44.6
28
38.4
213
42.5
0.69

I regularly apply biochemically derived themes and equations in my practice including formulas applicable to drug dosing, drug clearance, therapeutic drug monitoring, and detection of disease-specific biomarkers
99
61.9
180
66.4
46
63.9
325
64.7
0.629

Many of the procedures performed in medical practice require knowledge on biochemistry and genetics including sample collection, handling of specimens, and interpretation of lab results
130
81.3
222
81.3
59
80.8
411
81.2
0.995

I can efficiently interpret biochemical and genetic lab results and relate them to the overall clinical picture of the patient
123
78.8
221
81.0
53
73.6
397
79.3
0.389

I understand that it is essential to treat patients on an individual basis taking into consideration their genetic and environmental backgrounds
131
82.4
224
83.0
59
80.8
414
82.5
0.912

Data are presented as numbers and percentages. values were calculated using the chi-square test.

Table 3: Attitudes and perceptions of Jordanian physicians toward the contemporary advances in molecular medicine.

Statement
Interns (agree)
Residents (agree)
Specialists (agree)
Total
value

N
%
N
%
N
%
N
%

I appreciate the role played by biochemists in designing targeted therapy
103
65.6
169
62.8
47
66.2
319
64.2
0.787

Genetic or biochemical changes have been linked to many of the most common disorders including neuropsychiatric, autoimmune, endocrine, cardiovascular, and chronic inflammatory disorders
122
76.7
220
81.5
62
84.9
404
80.6
0.284

Genetic polymorphisms account for the patient’s variation in susceptibility to disease development, its complications, and response to treatment
133
83.6
236
87.1
57
79.2
426
85.0
0.218

I believe that sequencing the entire human genome will affect the quality of health care worldwide
121
76.1
205
75.9
51
69.9
377
75.2
0.475

I am familiar with whole genome association studies and appreciate how these studies advanced our understanding of multifactorial diseases
83
52.2
168
62.2
37
50.7
288
57.8
0.059

I support the routine use of modern molecular techniques in primary prevention, early diagnosis, and long-term follow-up of patients including DNA sequencing and expression microarrays
103
65.2
177
65.6
44
61.1
324
64.9
0.776

I am familiar with the term “epigenetics” and I understand how molecular alterations at this level may contribute to health and disease
69
43.9
152
57.1
34
47.2
255
52.2
0.023

I support establishing a DNA sequence database as part of a national health care plan
95
59.7
201
74.4
46
64.8
342
69.0
0.005

I am aware that the sequence of the human genome was published in 2003
80
50.3
148
54.6
32
43.8
260
51.9
0.24

I believe that the concept of “personalized medicine” as a treatment strategy can be applied in the conceivable future
82
51.6
168
62.2
44
61.1
294
59.1
0.087

I believe that “pharmacogenomics” may have the potential to maximize the therapeutic gain obtained from drugs and minimize their untoward effects
111
69.8
206
76.9
56
76.7
373
74.8
0.244

Data are presented as numbers and percentages. values were calculated using the chi-square test.

Table 4: Attitudes and perceptions of Jordanian physicians toward the need for continuous education in biochemistry and genetics.

Statement
Interns (agree)
Residents (agree)
Specialists (agree)
Total
value

N
%
N
%
N
%
N
%

I understand that a solid background in the principles of genetics and biochemistry is a cornerstone of modern clinical practice
111
70.7
213
79.8
48
65.8
372
75.3
0.018

Understanding metabolism is essential to comprehend the biochemical changes manifested in cancer
113
71.5
225
84.3
57
79.2
395
79.9
0.007

I am acquainted with the most recent molecular advances in my field of specialty
70
44.6
159
60.7
34
47.9
263
54.8
0.003

I believe that enrollment in continuing medical education (CME) courses in the topics of biochemistry and genetics will positively reflect on the quality of health care provided to the patients
101
63.9
214
80.5
55
75.3
370
75.2
0.001

I am familiar with the most common molecular techniques applicable to my practice
97
61.4
175
65.8
45
62.5
317
64.0
0.636

I believe that biochemistry and genetics principles added a significant value to contemporary clinical practice
107
68.2
195
73.9
55
75.3
357
72.4
0.367

I am frequently exposed to research articles that discuss the molecular basis of diseases
61
38.9
116
44.1
22
32.8
199
41.3
0.203

Upon reading research articles, I have enough background to understand the molecular tools employed by the authors to support their conclusions
75
47.5
136
50.7
30
41.7
241
48.6
0.377

Data are presented as numbers and percentages.

Table 5: Attitudes and perceptions of Jordanian physicians toward the current level of knowledge on biochemistry and genetics among medical students.

Statement
Interns (agree)
Residents (agree)
Specialists (agree)
Total
value

N
%
N
%
N
%
N
%

I believe that the current medical students are receiving more adequate training in biochemistry and genetics
62
39.2
116
43.6
36
49.3
214
43.3
0.343

I sense that there is a knowledge gap in biochemistry and genetics between previous and recent medical students
85
53.8
145
54.9
41
56.2
271
54.8
0.942

I strongly advise students to adopt a career path in biochemistry and genetics
94
59.5
188
70.9
46
65.7
328
66.9
0.054

I recommend that medical students get more in-depth training in biochemistry and genetics
99
63.1
194
73.8
48
68.6
341
70.0
0.068

The medical school curriculum currently offered in Jordanian universities is lacking in areas of biochemistry and genetics
95
60.1
174
65.4
46
63.9
315
63.6
0.549

Biochemistry and genetics were among my least favourite subjects during medical school
104
66.2
143
54.4
41
57.7
288
59.1
0.057

I believe that the main reason behind “phobia from Biochemistry” among students is that biochemistry depends heavily on abstract concepts that are intellectually challenging
97
61.8
184
69.2
57
80.3
338
68.9
0.019

The best way to motivate students to learn biochemistry is by translating biochemical concepts into relevant clinical scenarios
121
77.1
212
80.3
59
80.8
392
79.4
0.69

I support restructuring the curriculum in the Jordanian medical schools by integrating biochemistry and genetics with bedside teaching
111
71.2
189
71.6
50
68.5
350
71.0
0.874

Data are presented as numbers and percentages.

2.3. Data Collection and Analysis

The data were analysed using IBM-Statistical Package for Social Sciences (IBM-SPSS) version 22 (Armonk, NY). All variables in the study were categorical. The participants were first grouped according to their practice location (central or northern), their employment sector (private or public), or the country that awarded the MD or MBBS degree (Jordan or other countries) and were then cross-tabulated with their title (intern, resident, or specialist). The frequency of participants who answered yes or no to each question was calculated. Pearson’s chi-square test was used to test for statistically significant differences in the participants’ response according to each of the following four variables: practice location, employment sector, country of MD or MBBS, and title. To perform multivariate analysis, the response of participants to each statement was assessed using a 5-point Likert scale. An average attitude score was then calculated for each domain by calculating the mean of all responses (ranging from 1 to 5) to all the statements listed in that specific domain. A higher score indicated more positive attitude. Multivariate analysis of variables affecting the mean score of each domain was conducted using a general linear procedure (GLP). A value less than 0.05 was considered statistically significant.

3. Results

3.1. Sample Population

The response rate to the survey was 83%. Many of the interns (84.2%), residents (76.6%), and specialists (68.5%) who completed the survey were practicing in the private and public sectors in the northern part of Jordan at the time of the interview (Table 1). Furthermore, most of the interns (90.3%), residents (88.7%), and specialists (69.4%) obtained their first medical degree (MD or MBBS) from Jordan (Table 1). All the interns (100%) were practicing in hospitals affiliated with the public health sector. Moreover, majority of the residents (82.1%) and specialists (97.3%) were practicing in the public health sector as well. About three quarters of the interns (70.9%) and residents (72.4%), who were practicing in the public health sector, were working in hospitals affiliated with the Ministry of Health, while most of the specialists practicing in the public sector were working in hospitals affiliated with the Royal Medical Services (81.7%) at the time of the interview (Table 1).

In univariate analysis, only minimal variation was observed in the response of the study participants to the statements of the survey when comparisons were made according to the location of their employment (northern or central), country where they obtained their MD or MBBS degree (Jordan or others), or employment sector (private or public) (data not shown). However, more variation was observed in the responses when participants were grouped according to their professional title (intern, resident, or specialist) at the time of the interview (Tables 2–5). In this case, statistically significant differences were observed in the response of the participants to 11 different statements (Tables 2–5). We will thus initially present our findings considering differences in the response of the participants following their stratification according to their job title.

3.2. Attitude of Sampled Physicians toward the Integration of Biochemistry and Genetics Concepts into Clinical Practice

Most of the sampled participants indicated that they employ biochemical and genetic tests to reach the correct diagnosis (89.9%) and appreciate the importance of biochemical and genetic markers in detecting the early stages of the disease (89.3%) (Table 2). Moreover, four out of five participants (80.6%) believed that the physical signs of certain diseases are preceded by subtle biochemical changes and that a comprehensive treatment strategy should ideally correct the molecular basis of diseases rather than solely managing the resulting signs and symptoms (81.7%). However, despite their appreciation of the necessity of having a solid background in biochemistry and genetics for modern clinical practice (75.3%), less than half of the participants (42.5%) indicated that they consult with a clinical biochemist on a regular basis to better assist them in clinical decision-making (Table 2).

A higher percentage of residents, than interns or specialists, indicated that they were knowledgeable about the biochemical changes that result from hormonal imbalance (85.2%, ) or acidosis and alkalosis (79.8%, ) (Table 2). Residents were also more in favour of a role for proper nutrition in disease prevention than interns or specialists (86.1%, ) (Table 2).

3.3. Attitude of Sampled Physicians toward Contemporary Advances in Molecular Medicine

Most participants were familiar with the role of biochemistry or genetics in designing better targeted therapies (64.2%) and the role of genetic polymorphisms in determining disease susceptibility (85.0%) (Table 3). However, participants were less familiar with some of the breakthroughs in genetics like publishing the full sequence of the human genome (51.9%) and with concepts that recently gained more attention in the scientific community such as whole genome association studies (57.8%) and “epigenetics” (52.2%) (Table 3). Despite the positive attitude described above, there was a disparity among the participants in their support of establishing a DNA sequence database to expedite personalized medicine:74.4% of the residents supported this step, while only 64.8% of the specialists and 59.7% of the interns found this necessary (Table 3).

3.4. Attitude of Sampled Physicians toward the Need for Continuous Education in Biochemistry and Genetics

More than half of the interns (55.4%) and specialists (52.1%) admitted to not being familiar with the most recent molecular advances in their respective area of specialty/interest (Table 4). This may present a major hindrance discouraging them from reading relevant research articles where only 47.5% of the interns and 41.7% of the specialists feel that they have enough background in biochemistry and genetics to allow them to understand research articles that heavily depend on molecular-based techniques to support the findings (Table 4). However, a majority of the interns (63.9%) and specialists (75.3%) showed interest in attending CME courses, perhaps to address these and other deficiencies (Table 4). Noteworthy was the finding that the residents were significantly more familiar with the most recent molecular advances in their field (60.7%, ) and were significantly more open to enrollment in CME courses (80.5%, ) (Table 4).

3.5. Attitude of Sampled Physicians toward the Current Level of Knowledge on Biochemistry and Genetics among Medical Students

Most of the sampled participants believed that the medical school curriculum is still lacking in areas of biochemistry and genetics (63.6%) (Table 5). Moreover, more than two-thirds of the participants believed that biochemistry and genetics are intellectually challenging topics (68.9%) and were among their least favourite subjects of the medical school curriculum (59.1%) (Table 5). Given the above perception of the participants, it is not surprising that many of the participants recommended further restructuring of the curriculum to more efficiently integrate relevant clinical scenarios applicable to future bedside teaching (71.0%) (Table 5).

3.6. Multivariate Analysis of Variables Affecting Attitude of Physicians toward Biochemistry and Genetics

The results of this analysis are displayed in Table 6. Herein, the participants were first stratified according to their location, country of graduation, job title, employment sector, and years of experience. An attitude score (for each domain) was then calculated based on the response of the participants to each of the statements listed under each specific domain. A GLP was then used to test if significant differences in the attitude score were observed between different stratifications of the participants for each of the domains.

Table 6: Multivariate analysis of variables associated with the attitude of physicians toward the integration of biochemistry and genetics into clinical practice, advances in molecular medicine, the need for continuous education, and medical students’ knowledge on biochemistry and genetics.

Variable
Attitude toward the integration of biochemistry and genetics concepts into clinical practice
Attitude toward contemporary advances in molecular medicine
Attitude toward the need for continuous education in biochemistry and genetics
Attitude toward medical students’ knowledge on biochemistry and genetics

Mean
SD
value
Mean
SD
value
Mean
SD
value
Mean
SD
value

Location

0.799

0.364

0.310

0.306

Central
4.03
0.42

3.80
0.56

3.64
0.57

3.67
0.52

Northern
3.96
0.49

3.79
0.60

3.87
0.61

3.76
0.52

Country of graduation

0.219

0.644

0.838

0.730

Jordan
4.00
0.44

3.81
0.58

3.70
0.59

3.70
0.53

Others
4.07
0.41

3.73
0.50

3.60
0.54

3.66
0.49

Job title

0.206

0.170

0.101

0.725

Intern
3.94
0.38

3.75
0.57

3.58
0.52

3.64
0.52

Resident
4.07
0.44

3.86
0.56

3.78
0.59

3.72
0.53

Specialist
3.97
0.51

3.69
0.60

3.58
0.63

3.69
0.51

Employment sector

0.002

0.049

0.000

0.479

Private
4.08
0.55

3.87
0.77

4.20
0.56

3.81
0.60

Royal Medical Services
3.91
0.46

3.69
0.54

3.56
0.58

3.66
0.53

Ministry of Health
4.06
0.40

3.85
0.54

3.67
0.54

3.68
0.51

Years of experience

0.007

0.107

0.082

0.296

<5
3.98
0.41

3.79
0.58

3.69
0.58

3.67
0.53

≥5
4.05
0.47

3.80
0.56

3.68
0.58

3.71
0.51

Data are presented as mean and SD. value was calculated using a general linear procedure.

In this analysis, it was observed that the employment sector and years of experience were the only two variables significantly associated with any of the attitude scores of different domains included in the study questionnaire (Table 6). Specifically, physicians in the private sector had a significantly more positive attitude toward integration of biochemistry and genetics concepts into clinical practice (), toward contemporary advances in molecular medicine (), and toward the need for continuous education in biochemistry and genetics (). On the contrary, physicians with higher years of experience (>5 years) had a significantly more positive attitude toward integration of biochemistry and genetics concepts into clinical practice ().

4. Discussion

The results of this survey depict the attitude of physicians from various educational and professional backgrounds toward the content of the biochemistry and genetics curricula and their correlation with clinical teaching and practice in Jordan. Conclusions drawn from this study are expected to better inform medical educators and health policy-makers of the deficiencies of the current teaching methods of biochemistry and genetics and to provide guidelines of the best approach to mend these deficiencies. Notable was the finding that more than half of the physicians were familiar with some of the contemporary advances in biochemistry and genetics and the impact they have on modern medicine. Indeed, physicians were familiar with concepts like personalized medicine, whole genome association studies, and pharmacogenetics. Our results also demonstrated that most physicians appreciate the role biochemistry and genetics play in modern clinical practice including disease diagnosis and targeted therapy. However, despite the overall positive attitude, physicians were still reluctant to consult a clinical biochemist to help in the diagnosis and/or in monitoring disease progression. This might be explained by (a) the small number of individuals that hold professional board certification in clinical biochemistry in Jordan and (b) the lack of national board certification programs/fellowships in clinical biochemistry. Accordingly, Jordanian physicians are not used to having clinical biochemists as members of their medical teams.

Despite the relatively high response rate of this survey (83%), most of the nonresponders were from the southern part of Jordan. The authors, therefore, opted to exclude this geographic location from the final analysis. Southern Jordan primarily depends on the public sector to provide health services, and all of the physicians initially selected to participate in the survey were affiliated with the public sector. Unfortunately, southern Jordan is an underserved area, and physicians observe a high bulk of patients on a daily basis; this might explain why most of the physicians from southern Jordan declined to complete the survey.

All of the medical schools in Jordan currently teach biochemistry and genetics core concepts initially as independent subjects and then as part of an integrated and multidisciplinary syllabus [14, 15]. Before the year 1999, biochemistry and genetics were solely taught as independent subjects [14, 15]. Nonetheless, most of the survey participants believed that biochemistry and genetics are still inadequately covered by the current medical school curriculum. Indeed, despite the switch to the modular-based syllabus described above, most of the participants felt that the current curriculum would still benefit from further integration of clinical-based scenarios. This result is in agreement with several previous studies in other countries [5, 17–20] and could be explained by the fact that, in many of the Jordanian medical schools, the change in the content of the syllabus was not accompanied by a concurrent change in the instruction style of the basic medical science courses. Indeed, the teaching style of these courses still relies heavily on didactic sessions and lacks active student engagement.

In univariate analysis and upon the stratification of study participants according to their job title, residents showed the most positive attitudes relative to interns and specialists and were generally more knowledgeable about the biochemical aspects of multiple pathophysiological processes such as acid-base homeostasis and hormonal imbalance. Residents were also more open to sitting for CME courses. The overall more positive attitude of residents toward biochemistry and genetics could be explained by the fact that residents are more settled and oriented in their respective career paths compared to interns [21]. Additionally, in view of the competitive nature of their position, residents are required to regularly follow recent updates in their field of interest/future specialty [22].

In multivariate analysis, it was observed that physicians practicing in the private sector generally have a more positive attitude toward biochemistry and genetics than physicians practicing in the public sector. This was most evident in the attitude of physicians toward their need for continuous education in biochemistry and genetics. The reason behind this difference in attitude is not clear but could be related to a heavier workload on physicians in the public sector and a general lack of incentive for a continued education in biochemistry and genetics. Regardless, if this finding is confirmed in larger studies, it would provide health policy-makers with a clear incentive to target physicians in the public sector with educational programs to change their attitude toward biochemistry and genetics especially that rapid advancement in biochemistry and genetics is transforming medical practice and research.

This study has several limitations: Although the overall response rate of the survey was considerably in the higher range (83%) of comparable surveys, most of the nonresponders were physicians practicing in hospitals located in southern Jordan (data not shown). The responses of the above physicians were excluded from the final analysis. Accordingly, the study does not represent the viewpoints of all physicians practicing in Jordan. A more comprehensive national-scale study is required to overcome this limitation. Moreover, the questionnaire provided a subjective view of how physicians rate themselves and did not objectively test how much knowledge they possess on genetics and biochemistry. For example, the wording of some of the statements listed in Table 2 favours an affirmative answer from the responders. Despite these limitations, this survey is the first of its kind in Jordan and should be informative to medical educators in view of its structure and sample size.

5. Conclusions

In conclusion, physicians in Jordan, especially the residents, showed an overall positive attitude toward biochemistry and genetics. However, they felt that further restructuring of the medical school curriculum is warranted to better engage the students in learning biochemistry and genetics. This process should involve adopting a more interactive approach that requires student engagement in problem-solving, and the early introduction of clinical-based scenarios before bedside teaching at the hospital. Moreover, a better appreciation of the role of clinical biochemists in clinical decision-making could be achieved through the development of national programs that offer board certification in biochemistry and genetics. In multivariate analysis, this study showed that physicians practicing in the private sector or those who have more than five years of experience have a more positive attitude toward biochemistry and genetics. Accordingly, physicians practicing in the public sector or those at the beginning of their career could be a good target of CME courses in biochemistry and genetics than other groups of physicians.

Data Availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Conflicts of Interest

The authors declare that there are no conflicts of interest regarding the publication of this paper.

Acknowledgments

This work was supported by the Deanship of Research at JUST (368/2016) awarded to MN. The authors would like to thank Dr. Raed Said for his critical review of the manuscript.

References

C. M. Metallo and M. G. Vander Heiden, “Understanding metabolic regulation and its influence on cell physiology,” Molecular Cell, vol. 49, no. 3, pp. 388–398, 2013.

C. O. Madu and Y. Lu, “Novel diagnostic biomarkers for prostate cancer,” Journal of Cancer, vol. 1, pp. 150–177, 2010.

L. M. Hernandez and D. G. Blazer, Genes, Behavior, and the Social Environment: Moving beyond the Nature/Nurture Debate, The National Academies Press, Washington, DC, USA, 2006.

S. A. Scott, “Personalizing medicine with clinical pharmacogenetics,” Genetics in Medicine, vol. 13, no. 12, pp. 987–995, 2011.

M. J. H. Baars, L. Henneman, and L. P. Ten Kate, “Deficiency of knowledge of genetics and genetic tests among general practitioners, gynecologists, and pediatricians: a global problem,” Genetics in Medicine, vol. 7, no. 9, pp. 605–610, 2005.

M. A. Hamza, A. E. T. Idris, A. Almohanna et al., “Recall knowledge of biochemistry for interns after graduation from medical schools,” International Journal of Bioscience, Biochemistry and Bioinformatics, vol. 3, pp. 16–19, 2013.

J. Loertscher, D. Green, J. E. Lewis, S. Lin, and V. Minderhout, “Identification of threshold concepts for biochemistry,” CBE—Life Sciences Education, vol. 13, no. 3, pp. 516–528, 2014.

D. M. Irby and L. Wilkerson, “Educational innovations in academic medicine and environmental trends,” Journal of General Internal Medicine, vol. 18, no. 5, pp. 370–376, 2003.

H. B. White, M. A. Benore, T. F. Sumter, B. D. Caldwell, and E. Bell, “What skills should students of undergraduate biochemistry and molecular biology programs have upon graduation?” Biochemistry and Molecular Biology Education, vol. 41, no. 5, pp. 297–301, 2013.

P. W. Montague, ““How much biochemistry should a good doctor know?” Experiences from two new medical schools,” Biochemical Society Transactions, vol. 23, no. 3, p. 484s, 1995.

O. A. Owolabi, K. M. Anig, and N. M. Shuaibu, “Medical students’ and general practitioners’ perception of biochemistry in relation to medicine,” Biochemical Education, vol. 26, no. 1, pp. 18-19, 1998.

S. Gupta, A. Gupta, M. Verma, H. Kaur, A. Kaur, and K. Singh, “The attitudes and perceptions of medical students towards basic science subjects during their clinical years: a cross-sectional survey,” International Journal of Applied and Basic Medical Research, vol. 4, no. 1, pp. 16–19, 2014.

M. Panteghini, “The future of laboratory medicine: understanding the new pressures,” The Clinical Biochemist Reviews, vol. 25, no. 4, pp. 207–215, 2004.

S. Dabbo, “Medicine in Jordan: a cross-cultural elective experience,” University of Toronto Medical Journal, vol. 87, no. 1, pp. 18–20, 2009.

I. B. Hani, K. Al Saudi, and A. Alkafajei, “Innovative learning approaches in an established medical school: the experience at JUST in Jordan,” Eastern Mediterranean Health Journal, vol. 9, no. 5-6, p. 1085, 2003.

A. Tekian and J. Boulet, “A longitudinal study of the characteristics and performances of medical students and graduates from the Arab countries,” BMC Medical Education, vol. 15, no. 1, p. 200, 2015.

A. Wonkam, A. K. Njamnshi, and F. F. Angwafo, “Knowledge and attitudes concerning medical genetics amongst physicians and medical students in Cameroon (sub-Saharan Africa),” Genetics in Medicine, vol. 8, no. 6, pp. 331–338, 2006.

L. L. Marshall, D. L. Nykamp, and K. M. Momary, “Impact of abbreviated lecture with interactive mini-cases vs traditional lecture on student performance in the large classroom,” American Journal of Pharmaceutical Education, vol. 78, no. 10, p. 189, 2014.

S. Kumar, L. Jena, and J. Vagha, “Need assessment of enhancing the weightage of applied biochemistry in the undergraduate curriculum at MGIMS, sevagram,” Biochemistry and Molecular Biology Education, vol. 44, no. 3, pp. 230–240, 2016.

M. Sentí, R. Miralles, J. Bigorra et al., “A collaborative project to bridging the gap between basic and clinical teachers: the opinion of medical students,” Journal of Biomedical Education, vol. 2015, Article ID 620348, 9 pages, 2015.

J. R. Kogan, J. A. Shea, E. O’Grady, L. M. Bellini, and F. Ciminiello, “The impact of the internal medicine sub-internship on medical student career choice,” Journal of General Internal Medicine, vol. 25, no. 5, pp. 403–407, 2010.

C. P. West, T. D. Shanafelt, and J. C. Kolars, “Quality of life, burnout, educational debt, and medical knowledge among internal medicine residents,” JAMA, vol. 306, no. 9, pp. 952–960, 2011.