The emergence of extensively drug-resistant tuberculosis ( TB ) : TB / HIV coinfection , multidrug-resistant TB and the resulting public health threat from extensively drug-resistant TB , globally and in Canada

Globally, there are an estimated eight to nine million incident cases of tuberculosis (TB) annually. Approximately 40% are smear positive (1). Almost one-third of the world’s population (approximately two billion), who are mainly living in developing nations, are infected with TB (Mycobacterium tuberculosis infection) (1). Sub-Saharan Africa continues to report the highest burden of HIV (2-4) and accounts for approximately 70% to 90% of the estimated 40 million persons infected with HIV (2-4). This African region represents over 70% of global AIDS mortality, with females bearing a higher AIDS burden (2). Together with Southeast Asia, south Asia and the western Pacific region, it also has the highest prevalence of TB infection and active TB disease (1). Since the mid-1980s, sub-Saharan Africa has experienced an upsurge in TB. This escalation of incident disease has been attributed to HIV, given the previous years of stable TB rates within the region (1,5,6). HIV is emerging as a major impediment to TB control and is becoming a major focus of TB prevention efforts, especially for less developed nations. HIV and TB have overlapping epidemiologies. TB is the most common infection reported in persons with HIV. Coinfection with TB and HIV presents challenges beyond treating the individual infection. HIV infection with primary TB leads to more severe infection and promotes reactivation of latent TB. Active TB disease is linked to increments in HIV viral load, locally and systemically, thus, potentially facilitating AIDS sequelae and mortality (7,8). The prevalence of HIV infection in new adult cases of TB was 11%

Resistance to anti-tuberculosis (TB) drugs continues to present a major challenge to global public health.Resistance usually develops due to inadequate TB management, including improper use of medications, improper treatment regimens and failure to complete the treatment course.This may be due to an erratic supply or a lack of access to treatment, as well as to patient noncompliance.However, the emergence and transmission of drug-resistant TB, including the recently detected extensively drug resistant TB (XDR-TB), is driven, in part, by the synergistic relationship between TB and HIV (TB/HIV coinfection).There is evidence that persons infected with HIV are more likely to experience XDR-TB.XDR-TB is virtually untreatable with available TB medications.XDR-TB presents a grave global public health threat, particularly in high HIV prevalence settings.The present commentary discusses the current status of XDR-TB and draws attention to the urgency in addressing this problem, for both the global and Canadian public health networks.XDR-TB and the apparent XDR-TB and HIV association warrants further study.
in 2000 (1).Approximately 9% of adult cases were attributable to HIV infection (1,4).Of the nearly two million estimated deaths from TB in 2000, 12% were attributed to HIV and an estimated 11% of all adult AIDS deaths were caused by TB (1).Thus, TB reshapes HIV epidemiology globally because it is the major contributor to morbidity and mortality in persons infected with HIV (1,5,6,(9)(10)(11).

Multidrug-resistant TB
One consequence of the HIV and TB coepidemics is the increasing occurrence of drug-resistant TB.Resistance to TB therapies can result from improper or incomplete treatment, as well as from patient noncompliance with treatment (12,13).Drug resistance to available TB therapies makes the treatment of TB difficult and expensive; toxic drugs may be required whose effectiveness may be uncertain.Multidrug-resistant TB (MDR-TB) is defined as resistance to at least isoniazid (INH) and rifampicin ( 14); globally, it has been recognized as a threat to TB control for many years.MDR-TB emerged and became widespread, in part, because of HIV coinfection (15,16).HIV coinfection promotes MDR-TB (12,13,17,18) not only in less developed regions -MDR-TB outbreaks in the United States documented that MDR-TB is highly contagious, often nosocomially acquired within closed settings such as prisons, shelters and hospitals and, for many cases, associated with HIV infection.Such highly drug-resistant institutional-type outbreaks typically result in death unless they are quickly and correctly treated.While antiretroviral treatment for HIV has aided in decreasing mortality in TB/HIV coinfected persons, drug-resistant TB and MDR-TB strains have increased the mortality in those who are coinfected.This threatens the success of antiretroviral therapy programs for HIV infection, as well as TB control programs.

Extensively drug-resistant TB
A more recent and alarming global public health threat has emerged with the identification of extensively drug-resistant tuberculosis (XDR-TB) -a highly pathogenic strain of TB developing from MDR-TB (17)(18)(19)(20)(21)(22)(23).The present laboratory case definition of XDR-TB (approved by the World Health Organization [WHO] Global Task Force on XDR-TB in 2006) is given as TB resistant to at least rifampicin and INH (consistent with the case definition for MDR-TB) (14,19), in addition to any fluoroquinolone and at least one of three injectable medications (capreomycin, kanamycin and amikacin) used in TB treatment.Furthermore, the WHO defines XDR-TB as MDR-TB that is resistant to three or more of the six classes of second-line drugs (19,20).HIV infection appears to be the impetus for the emergence of this highly virulent strain.
The epidemiological characterization of XDR-TB's distribution remains limited due to the relatively recent recognition of the problem.Nations presently impacted by XDR-TB include Peru, the Philippines, South Africa, Swaziland, Lesotho, Estonia, Latvia, United States, South Korea and Iran (17,19,21).However, the WHO and the Centers for Disease Control and Prevention suggest that the virtually untreatable XDR-TB may exist in all nations (20).Of 17,690 global TB isolates identified between 2000 and 2004, 20% were MDR-TB and 2% were XDR-TB.Fifteen per cent of MDR-TB strains in South Korea were identified as XDR-TB in 2004, and 19% in Latvia between 2000 and 2004 (20,21).This review also reported that for the study period, 4% of MDR-TB cases in the United States were classified as XDR-TB (20,21).An Iranian study (17) reported that 8.8% of 1284 isolates were MDR-TB and, of those, 12 isolates (10.6%) in a single-family closecontact cluster showed resistance to all eight second-line medications, and were thus classified as XDR-TB.In a South African study (18), 14.4% of 1539 isolates were MDR-TB and 53 were XDR-TB.In that study, all XDR-TB patients tested were HIV positive, 85% of XDR-TB strains were similar and 98.1% of XDR-TB patients died, even with access to antiretroviral medications (18,20).The median survival period from XDR-TB diagnosis was only 16 days.
These initial reports confirm XDR-TB's contagiousness, ease of spreading among populations coinfected with HIV and rapid mortality, if left untreated.The presence of XDR-TB in populations with HIV is particularly concerning.While the current knowledge is sufficient to identify the issue as one of significant global public health concern, still XDR-TB is an emerging phenomenon.
Is XDR-TB a public health concern for Canada?XDR-TB must be regarded as a health concern here in Canada.Even if one infectious patient with XDR-TB was identified in Canada, the high lethality, lack of treatment options and transmissibility would constitute a public health emergency.Epidemiological data suggest that most resistant strains of TB detected in Canada originate from foreign-born patients (14).This knowledge, together with the unique concerns of TB/HIV coinfection as a promoter of XDR-TB, needs to be considered in developing strategies to address this problem in Canada.

FUTURE CONSIDERATIONS
The immediate public health significance of XDR-TB must be recognized, and programs should be developed to address the challenge, both globally and within Canada.There is an urgent need to characterize the extent and geographical distribution of XDR-TB.Sex-stratified data are essential, as well as characterization of differences in clinical features, if any, among men and women.Characterization of the extent of both MDR-TB and XDR-TB among children is needed, as well as among vulnerable and marginalized high-risk subpopulations, such as the Native population within Canada.Studies characterizing the genetics, biochemistry and molecular characteristics of XDR-TB infection in persons both with and without HIV infection are also essential.
Increased TB and HIV program collaboration should be considered.In light of the severity of XDR-TB based on emerging evidence, existing TB control programs should be realigned toward strategies that enhance TB and HIV prevention, detection and control, nationally and globally.TB control programs should incorporate HIV testing and counselling services if they are not already doing this.Increased testing and treatment for TB in HIV testing centres and infected patients should also be promoted.Intensified efforts for active TB case findings, particularly in HIV-infected persons, should be pursued.The detection and control of HIV-linked TB, especially in regions of elevated HIV prevalence, are paramount.Urgent intervention must be accompanied by testing for XDR-TB, especially in developing nations with elevated TB, HIV and TB/HIV coinfection rates.Screening and testing with treatment for sexually transmitted diseases among TB patients may also mitigate the risk for HIV, with the potential for reducing The emergence of MDR-TB and XDR-TB highlights the need for cheaper, safer and more effective anti-TB second-line treatments.Intensified and expanded directly observed therapy short-course TB treatment programs, especially in high HIVprevalent populations, may limit the spread of XDR-TB.Increased TB case findings and detection, as well as testing of HIV-positive persons for TB infection and subsequent INH preventive therapy to prevent disease sequelae are also necessary.Challenges in the concurrent treatment of TB and HIV include drug toxicity.There is also a need for quality-assured laboratory testing, including rapid diagnostic testing, to minimize the transmission of drug-resistant TB.Laboratory surveillance for MDR-TB must include XDR-TB.
Canadian prevention and control programs can address the emerging XDR-TB threat by refining existing TB control programs to include XDR-TB (eg, in patient management).This can include second-line drug susceptibility testing, adoption of the WHO's case definition, availability of rapid diagnostic testing and training for diagnosticians to recognize cases, enhanced infection control strategies, enhanced acute surveillance to monitor XDR-TB, and increased collaborations and communications on XDR-TB within public health systems.
Mandatory reporting of XDR-TB cases to local, provincial or federal health ministries, and increased funding for antimicrobial (anti-TB) drug research in Canada, must also be addressed.

CONCLUSION
XDR-TB is a global public health threat because it is virtually untreatable.It is currently more prevalent than global, regional, national or local public health systems have recognized, and there is no room for complacency.Urgent action is needed to prevent XDR-TB from further dissemination.Global public health is now confronting a form of TB that responds poorly to available treatments and prevention efforts.The emergence of XDR-TB has the potential to reverse the gains made by TB and HIV control programs, with major implications for developing nations that have high rates of both TB and HIV infection (18).It may also be relevant to at-risk persons living in congregated settings, institutions or rural communities where prevention and treatment services may be limited.Left unchecked, global HIV and TB epidemiology will be reshaped by MDR-TB and XDR-TB, and by their intersection with the continuing HIV epidemic.Fortunately, HIV infection is preventable, and drug-susceptible TB is curable.We need to rapidly and fully implement strategies to address this new challenge.
Emergence of extensively drug-resistant TB Alexander and Dethe sexually transmitted disease, HIV, active TB disease, MDR-TB and XDR-TB sequelae.