Prevalence and Determinants of Diarrheal Diseases among Under-Five Children in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia: A Community-Based Cross-Sectional Study

Background Diarrheal diseases are the leading cause of preventable death, especially among under-five children in developing countries, including Ethiopia. Although efforts have been made to reduce the morbidity and mortality resulting from diarrheal diseases, there is scarce information on the progress of the interventions against the burdens. Therefore, this study aimed to assess the prevalence of diarrhea and its associated factors in under-five children in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia. Methods A community-based cross-sectional study was conducted. Of 12,316 households, 620 households that had under-five children were selected by simple random sampling technique from randomly selected kebeles. Before data collection, a pretest of the structured questionnaires was done on nonselected kebeles. Binary logistic regression was used to assess the association of the diarrheal diseases with independent variables. Finally, the odds ratio along with a 95% confidence interval was used to report the significant association between the outcome variable and its associated factors. A P value of ≤0.05 was considered statistically significant Results The prevalence of diarrhea among under-five children was 149 (24%) (95% CI: 20.8, 27.3). Diarrhea was significantly associated with poor knowledge of mothers/caretakers on diarrhea prevention methods (AOR: 2.05, 95% CI (1.14, 3.69), being in the age group of 6–11(AOR = 1.546 (1.68, 3.52), and 12–23 months (AOR = 1.485 (1.84, 2.63)), families with poor wealth index (AOR: 2.41, 95% CI (1.29, 4.51)), children who were not vaccinated against measles (AOR: 4.73, 95% CI (2.43, 9.20)), unsafe child feces disposal (AOR = 3.75; 95% CI (1.91, 7.39)), inappropriate liquid waste disposal (AOR = 3.73 (1.94, 7.42)), and having two or more siblings (AOR: 3.11, 95% CI (1.81, 5.35)). Conclusion and Remarks. The prevalence of diarrhea among under-five children was high. There was a statistically significant association between diarrhea and age of the child (6–11 and 12–23), poor knowledge of mothers/caretakers on diarrhea prevention methods, families with poor wealth index, being unvaccinated against measles, improper liquid waste disposal, unsafe child feces disposal, and having at least two siblings. The findings have a significant policy inference for childhood diarrheal disease prevention programs. Therefore, educating mothers/caregivers on diarrheal disease prevention methods, child spacing, regular hand washing practice after disposing child feces, safely disposing liquid waste, and vaccinating all eligible children against measles should be a priority area of intervention for diarrheal disease prevention. Moreover, since these associated factors are preventable, the government needs to strengthen the health extension workers program implementations to reduce childhood diarrhea.


Introduction
Diarrhea is the passage of unusually loose or watery stools, at least three times in 24 hours. However, it is the consistency of stools rather than the number that is most important. Frequent passing of formed stools is not diarrhea. Babies fed only breast milk often pass loose, "pasty" stools; this is also not diarrhea [1].
ere are three main forms of acute childhood diarrhea, all of which are potentially life-threatening and require different treatment courses (acute watery diarrhea, bloody diarrhea, and persistent diarrhea) [2].
Diarrhea is more prevalent in the developing world in the large part due to the lack of safe drinking water, sanitation, and hygiene, as well as poorer overall health and nutritional status. According to the latest available figures, an estimated 2.5 billion people lack improved sanitation facilities, and nearly one billion people do not have access to safe drinking water. ese unsanitary environments allow diarrhea-causing pathogens to spread more easily [1].
Globally, there are nearly 1.7 billion cases of childhood diarrheal diseases that account for one in nine child deaths, making diarrhea the second leading cause of death in children under five years old. Even though diarrhea is both preventable and treatable, it kills 525,000 children under five years old each year, and it is a leading cause of malnutrition in children under five years old [3]. e majority (42%) of deaths due to diarrheal disease were concentrated in Sub-Saharan Africa, including Ethiopia (88 per 1000 live births), where hygiene and sanitation are poor [4]. Improved sanitation is one that hygienically separates human excreta from human contact and an improved drinking water source is one that by the nature of its construction adequately protects the source from outside contamination, in particular from fecal matter, and generally, a systematic study conducted in London school of hygiene and tropical medicine revealed that improvement in hygiene especially hand washing with soap alone showed 48% reduction in diarrhea mortality [5]. Even though 63% of the global population use toilet and other improved sanitation facilities, a significant proportion, about 2.6 billion people, lack improved sanitation and 1.1 billion people (15% of the global population) practice open defecation [6].
In Ethiopia, 3/4 of the health problems of under-five children are communicable diseases that come from the environment, especially water and sanitation. Diarrhea is the leading cause of the mortality of under-five children, causing 23% of deaths and around 44% stunting, and in Ethiopia, over 75-80% of communicable diseases are caused due to poor environmental health conditions arising from unsafe and inadequate water supply and poor hygienic and sanitation practices [2]. Nearly two-thirds of the households (65%) obtain their drinking water from improved sources according to the 2016 EDHS report, which declared visible improvement compared with the 2011 EDHS report (54%). e most common source of drinking water in a rural area is a public tab or standpipe (19%), tube well or borehole (13%), and protected spring (14%) [7].
is study considers ODF as a factor that was not considered in all reviewed literatures, except that the sustainability of the program was tested in our country and Asia [8]. Even though the sanitation coverage of the Hababo Guduru District is 76%, open defecation practice is dominant in the district according to the 2009 EC of the district report [9]. Using unsafe drinking water like unprotected springs, wells, rivers, and streams is also the most prominent problem in this area, which is one of the most important causes of diarrheal diseases. Likewise, as far as the investigator's knowledge, no study was conducted in the study area before now. As a result, this study helps to reveal and assess the prevalence and associated factors of diarrhea in underfive children with different demographic and socioeconomic, environmental, and behavioral factors.

Study Design and Setting.
A community-based crosssectional study was conducted from February 15 to March 10, 2018, in Horo Guduru Wollega Zone, Oromia Region, Western Ethiopia, which is located nearly 315 km away from the capital, Addis Ababa. e zone has 12 districts, 11 rural and one urban, and the total population was estimated as 824,205 (male: 412,927 (50.1%); female: 411,278 (49.9%)), and the total numbers of households were 12715 and underfive children in the zone were 123,631.

Population and Eligibility Criteria.
All under-five children living in Horo Guduru Wollega Zone were the target population, while children living in randomly selected kebeles in the Horo Guduru Wollega Zone were the study population. Mothers/caregivers-child pairs living in Horo Guduru Wollega Zone for more than six months were eligible for the study.

Sample Size and Sampling Procedures.
e sample size was determined using EPI-INFO version 7 software programs for double population proportion formula with a 95% level of confidence, 80% power, and design effect of 1.5 and considering the number of under-five siblings [6]. en, by adding 10% of contingency for the nonresponse rate, the sample size was determined to be 624. A stratified sampling method was employed to select households that had underfive children. Out of twelve districts, three districts were selected by lottery method. By applying the proportional to size allocation method, households with under-five children were selected from each selected kebele. To select each study participant, a simple random sampling technique from the sampled kebeles was used after enumerating the households with under-five children from each of the selected kebeles based on the sample size allocated. Households with at least one under-five child were selected. From the household that has more than one under-five child, only one of the children was randomly selected (Figure 1).

Data Collection Instruments and Procedures.
e data were collected by using a structured questionnaire interview. e questionnaires were initially prepared in English and then translated into Afaan Oromoo (the local language of the study area). e data collection questionnaire was developed from the literature review. e adapted questionnaires were modified and contextualized to fit the local situation and the research objective. e data collection was conducted by eight clinical nurses and two BSC holders, which were health officers, assigned as supervisors. A two-day training was given for data collectors and supervisors on how to approach the study groups and fill the questionnaires by the principal investigator. Data collection was performed through houseto-house visits. e data collectors explained the purpose of the study and convinced the study participants to get their consent. For households with two or more children underfive years of age, the candidate child was selected by a lottery method.

Study Variables.
e diarrheal disease was an outcome variable of the study independent variables. e sociodemographic and economic variables were as follows: age and sex of the child, mother's education and occupation, and marital status of the mother. Environmental health condition variables were as follows: availability of a toilet facility, type of the toilet, main source of the drinking water, accessibility of drinking water, availability of hand washing facility, hand washing practice, latrine utilization, child's feces disposal practice, water storage practice at home, water treatment practices at home, child feeding practice, measles vaccination status and open defecation field (ODF) status, and knowledge-related variables.

Operational Definitions
Diarrhea: a child having a history of passing loose stool more than three times per day in the two weeks before the data collection period [10] was considered suffering from diarrhea.
Narrow-neck storage container: a jerrican was considered a narrow-neck water storage container, while buckets and pots were considered wide-neck water storage containers.
Knowledgeable: a child's mothers/caretakers who scored above the mean value on answering the knowledge-related questions about diarrheal disease prevention methods were assigned "knowledgeable." Poor knowledge: a child's mothers/caretakers who scored the mean and below the mean value on answering the knowledge-related questions about diarrheal disease prevention methods were assigned "poor knowledge."

Data Collection Methods and Instruments.
Data were collected through house-to-house visits using a structured questionnaire, developed from different kinds of literature. e questionnaires were initially prepared in English and then translated into Afaan Oromoo (the language of the study area). e data collection was conducted by ten clinical nurse professionals and supervised by three public health professionals.

Data Quality Control.
e principal investigator provided two days of training for the data collectors and supervisors on the objectives of the study and how to approach the study participants. A pretest was conducted on 5% of study participants living in the nonselected kebeles before the actual data collection period. e data quality was managed at every level of the data collection process. Once the collected data quality consistency and completeness are checked, data were separately entered into EpiData version 3.1 software by two data clerks.
en, data entered into EpiData software were exported to SPSS version 22 for analysis.

Data Analysis.
e outcome variable was diarrhea that was dichotomized into having diarrhea in the past two weeks before the data collection period ("Yes" vs "No"). Frequency, proportions, and measures of central tendency were calculated to describe the study subjects. e family wealth index was constructed by using the principal component analysis (PCA) method and considering locally available household assets. Family wealth was categorized into poor, medium, and rich. e multicollinearity effect was tested using the VIF for all independent variables, and no variable was found to have VIF greater than ten. Binary logistic regression was used to assess the associations between dependent and independent variables. Variables that had a P < 0.25 in the bivariable analysis were transformed to multivariable analysis. In the multivariable analysis, the adjusted odds ratio (AOR) with its 95% CI was used to determine factors significantly associated with diarrhea in underfive children. A P value less than 0.05 was considered statistically significant.
e fitness of the model was tested by Hosmer-Lemeshow.

Sociodemographic Characteristics of Study Participants.
A total of 620 households were included in the study with a 99.4% response rate. ree hundred forty-seven (56%) mothers/caretakers were in the age group of 25-34 years, and their mean age and SD was 33 ± 5.54 years. About half of the children (323 (52.1%)) were males. Two hundred seventy-seven (44.7%) children were aged 12-23 months, and their mean age and SD was 20 ± 10.6 months. e majority of mothers (576 (92.6%)) were married at the time of the study, and 212 (34.2%) were unable to read and write. e mean family size was 5.4 ± 1.6 SD. More than one-third of the participants (222 (35.8%)) come from poor families.
Concerning the mothers' knowledge on prevention methods of diarrhea in under-five children, the majority (315 (50.8%)) had poor knowledge (Table 1).

Environmental Characteristics.
e majority of the households (527 (85.0%)) had a private latrine facility, and more than one-third (348 (1%)) had pit latrines with a slab. Five hundred sixty-three (90.8%) mothers disposed the child's feces into the latrine. About 277 (44.7%) and 379 (61.1%) of the households disposed their solid and liquid wastes everywhere openly, respectively. One hundred seventy (27.1%) and 257 (41.5%) of the households used piped system and protected spring water for drinking purpose, respectively, whereas 331 (53.4%) of the households drunk water without any treatment at their home ( Table 2).

Factors Associated with Diarrhea in Under-Five Children.
Children whose mothers/caretakers had poor knowledge on diarrhea prevention methods had diarrhea two times more likely than children whose mothers had good knowledge (AOR � 2.05; 95% CI: (1.14, 3.69)). e odds of having diarrhea were 4.7 times more likely in children who were unvaccinated for measles compared with their counterparts (AOR � 4.73; 95% CI: (2.43, 9.20)). e odds of having diarrheal diseases in children whose family inappropriately disposed liquid waste were 3.73 times more likely compared with a family that practiced appropriate disposal of liquid waste (AOR � 3.73; 95% CI: 1.94, 7.42).
Children in the age group of 6-11 months and 12-23 months were 1.5 times (AOR � 1.546; 95% CI: 1.68, 3.52) and 1.4 times (AOR � 1.485; 95%CI: 1.84, 2.63) more likely to have diarrhea than children in the age group of 24 and above months. Children from a family who had two and more siblings were 3.1 times more likely to have diarrhea than children from a family who had only one sibling (AOR � 3.11; 95% CI: 1.81, 5.35). e odds of diarrheal diseases in children whose parents had poor wealth index were 2.41 times more likely compared with children from a family who had a rich wealth index (AOR � 2.41; 95%CI: 1.29, 4.51) ( Table 3).

Discussion
is study uncovered the determinants of diarrhea among children under five years old in Horo Guduru Wollega Zone, Western Ethiopia, which were as follows: children aged 6-11 and 12-23 months, poor knowledge of mothers/caretakers on diarrheal disease prevention methods, children unvaccinated for measles, inappropriate liquid waste disposal 4 Canadian Journal of Infectious Diseases and Medical Microbiology system, having more than one child in the family, household with a poor wealth index, and unsanitary feces disposal. is study examined the sociodemographic and socioeconomic characteristics, feeding and healthcare characteristics, and environmental characteristics associated with diarrheal status in under-five children.
e current study showed that, in this study, the prevalence of diarrhea in underfive age children was 24% (95% CI: 20.8-27.3). e prevalence of diarrhea in under-five children in this study was comparable with a study conducted in Cameroon in Sub-Saharan Africa [10] and Eastern Ethiopia (22.5%) [11]. e prevalence of diarrhea in this study was lower compared with cross-sectional studies conducted in Niger (36.4%), North West Burundi (32.6%), and Afar Region (37.5%) [12][13][14]. However, the finding was relatively high compared with a study conducted in Ghana (13%) [15] and Southern Ethiopia (13.6%) [16]. A discrepancy could be due to the study population difference. e study showed that diarrhea was significantly associated with children in the age groups 6-11 months and 12-23 months compared with children aged more than or equal to 24 months. is finding is in agreement with other studies [11,[17][18][19]. Children in this age group may experience mouthing of visibly dirty fomites, feces, soil, and other dirty objects. erefore, the possible explanation may be due to the mouthing of contaminated objects with diarrheacausing pathogens, making this group of children at a greater risk of developing diarrheal diseases. e study revealed that the odds of having diarrhea were higher among families who had at least two siblings compared with those who had only one under-five child.
is is in agreement with a study conducted in Cameroon [10], Eastern Ethiopia [11], Uganda [20], and Northern Ethiopia [21]. is might be due to the incapability of parents to provide a balanced diet, safe and clean water,   appropriate sanitation service, and early medical care when getting sick. e study found that the odds of diarrheal diseases in children whose families had a poor wealth index were higher than children whose families were rich. is study's result was in line with a study conducted in Northeast Ethiopia [14]. Being poor may form situations that favor the spread of infectious diseases like diarrhea and limit affected peoples from gaining sufficient access to prevention and care. e possible explanation may be that rich families may have a greater opportunity to use adequate water and soap for hands washing and aqua-guard at their houses to protect against microbial contamination in water, and they may construct a toilet. In addition, the living room and kitchen floor type affects the level of pathogen load that may cause diarrheal diseases. For instance, poor families might construct the floor of the living room or kitchen from mud, which serves as a source of fecal-oral route of transmission of diarrhea causative agents, unlike cemented floors.
Children who were not vaccinated against measles had higher odds of developing diarrheal diseases than their counterparts. is finding is supported by studies conducted in low-and middle-income countries [22] and African and Asian countries [23]. Any child who is not vaccinated against measles has a high probability of developing measles infection. As a result, children may develop measles, which indirectly causes diarrhea as a complication or secondary infection to measles.
Findings on liquid waste disposal showed that children of mothers/caretakers who practiced inappropriate disposal of liquid waste had higher odds of diarrhea compared with children whose mothers/caregivers who practiced proper disposal of liquid waste. is study was consistent with a study from Senegal [24] and Somali Region [25]. is can be explained by the fact that liquid waste contains different diarrheal causing germs, which can be easily distributed by flies. Inappropriate management of the liquid waste pathogens may contaminate foods that the child eats.
Children whose families inappropriately handled feces disposal had higher odds of contracting diarrheal diseases than their counterparts. is was in line with the studies conducted in Benishangul-Gumuz Regional State [19] and Significant association � * (P < 0.05); COR: crude odds ratio; AOR: adjusted odds ratio; CI: confidence interval.
Northeast Ethiopia [26]. is can be due to transmission of diarrheal diseases from an infected host to a healthy individual through the contamination of the foods/utensils or drinking water with the infected feces. In addition, both liquid and solid wastes can be the breading sites of insects that serve as a carrier for diarrheal disease causing pathogens.

Conclusion and Remarks
is study showed the prevalence of childhood diarrhea was high (24%). Children aged 6-11 and 12-23 months, presence of two or more under-five children in the family, mothers/ caretakers' knowledge on diarrheal disease prevention methods, inappropriate liquid waste disposal, being unvaccinated against measles, unsafe dispose of feces, and coming from a family with poor wealth index were statistically associated with diarrhea. e findings have a significant policy inference for childhood diarrheal disease intervention programs. erefore, educating mothers/ caregivers on diarrheal disease prevention methods, child spacing, regular hand washing practice after disposing feces, safely disposing liquid waste, and vaccinating all eligible children against measles should be a priority area of intervention for diarrheal disease prevention. Moreover, since these associated factors are preventable, the government needs to strengthen the health extension workers program implementations.

Data Availability
e data used to support the study findings are available from the corresponding author upon request.

Conflicts of Interest
All authors declare that they have no conflicts of interest.