A Decision-Making Framework Using q -Rung Orthopair Probabilistic Hesitant Fuzzy Rough Aggregation Information for the Drug Selection to Treat COVID-19

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Introduction
Wuhan, China, was faced with a dangerous challenge in December 2019, which distorted the health of humans and created global instability. e pneumonia cases were caused by a new virus known as coronavirus 2019 . COVID-19 was unknown; therefore, the government of China controlled Wuhan's traffic to prevent the spread of the infection [1]. Russia, the United States, Brazil, India, and France are the most infected countries in terms of the number of confirmed COVID-19 cases. e World Health Organization (WHO) recognized COVID-19 as a pandemic by March 2020. Several governments and organizations have been closed down and have implemented strict social distancing processes to prevent virus proliferation. According to a WHO report released on June 13, 2021, more than 176,396,104 cases of COVID- 19 have been reported around the world, resulting in more than 3,810,989 deaths, and a total of 160,398,032 people have been recovered [2]. e virus that causes COVID-19 is primarily spread via the droplets created when someone infected with COVID-19 sneezes, coughs, or exhales. Coronavirus is more harmful to those who have a low immune system, are elderly, have diabetes, or have medical problems, especially for those involving the lungs problem [3][4][5][6]. Virus propagation can be influenced by various factors, including population density, medical care facilities, climate, and others [7]. Coronaviruses are a vast family of viruses that can cause various diseases in both animals and humans. ey mainly cause respiratory tract infections in humans, varying from an ordinary cold towards more severe illness disorders such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) [8,9]. Phylogenetic and sequencing analyses have shown that COVID-19 is closely related to a collection of human and bat SARS-like coronaviruses [4,10,11]. COVID-19 is believed to have evolved from bats to a greater level of life chains [12][13][14]. e statistic is shown in Figure 1. Doctors, experts, or medical sections should implement an ideal plan, tests, or techniques for the COVID-19 treatment process to avoid further crisis expansion.
e department in the process of establishing strategy must make quick and effective decisions. While making decisions in this situation, individuals are often bound logically instead of entirely reasonable. As a result, it is essential to identify appropriate multicriteria decisionmaking (MCDM) models that recognize human activities to provide individuals with practical ways of responding to emergencies. Dealing with uncertainty and unpredictable information in realistic circumstances has always been challenging. Several tools have been developed to address the complexities and conflicts encountered in real-life activities. Zadeh [15] explored a solution to such problems by establishing the foundations of fuzzy set (FS) theory, in which each element is assigned a membership degree ranging between 0 and 1. Atanassov [16] extended the idea of FS into intuitionistic FS (IFS) by introducing nonmembership (ψ 5 (x)) to the membership (β F (x)) of the FS, with the restriction that β 5 (x) + ψ 5 (x) ≤ 1.
Yager [17] introduced the Pythagorean FS (PFS) theory, which relaxes the previously mentioned IFS condition to (β 5 (x)) 2 + (ψ 5 (x)) 2 ≤ 1. PF expressions are undoubtedly raising the interest of many researchers, especially in terms of their applications to DM. For example, Huang et al. [18] described a PF MULTIMOORA approach that utilizes a novel distance measure and a score function. ey used this approach to evaluate disk productions and energy projects. Zhang and Xu [19] established the TOPSIS approach in a Pythagorean fuzzy environment and used it to assess the efficiency of private airline services.
Hesitancy is a natural phenomenon in the universe. Identifying the better alternatives having the same characteristics in daily life is complicated. Due to the uncertainty and hesitancy of the results, professional experts are experiencing difficulty in DM. To tackle hesitancy, Torra [20] developed the concept of hesitant FS (HFS). e HFS can be used to solve a variety of DM problems. Many authors used HFS to solve issues by aggregating operators (AOPs) in group DM (for detailed information, see [21][22][23][24]). Liao and Xu [25] identified generalized forms of the HF hybrid weighted averaging (HFHWA) operator, the HF hybrid weighted geometric (HFHWG) operator, generalized form of the quasi-HFHWA operator, and the generalized form of the quasi-HFHWG. Khan et al. [26] introduced the concept of Pythagorean HFS (PyHFS). ey established an evaluation method and identified operators for data aggregation. Xu and Zhou [27] identified a novel concept of probabilistic HF sets (PHFSs). Inspired by the power of PHFSs, researchers extensively investigated the idea of multiattribute decision-making (MADM) (see [28][29][30] for detailed information). Yager [31] established a new idea called q-rung orthopair FSs (q-ROFSs), in which the number of the qth exponent of support for membership and the qth exponent of support nonmembership is restricted to one, i.e., (β 5 (x)) q + (ψ 5 (x)) q ≤ 1, and demonstrated that the q-ROFS is more general than the IFS and PFS. e q-ROFSs provide a broader range of fuzzy information and are the versatile and appropriate approach to deal with unpredictable situations. Yager and Alajlan [32] explored the fundamental properties of these q-ROFSs and discussed how they can be used in information representation. Subsequently, the authors in [33] put forward the notation of q-rung orthopair HF set (q-ROHFS) and explored the operational laws which exist for any two q-ROHFSs. Wang et al. [34] investigated the Heronian mean operators in MADM in a q-ROHFS framework. ey also proposed the Hamacher norm-based AOPs under dual hesitant q-ROFSs and discussed their usefulness in DM problems. Wang et al. [35] established the AOPs based on Muirhead mean under dual hesitant q-rung orthopair fuzzy information. Hussain and Yang [36] measured the entropy for HF information using the Hausdorff metric and the structure of HF TOPSIS. e TOPSIS is a valuable information analysis tool developed by Hwang and Yoon [37]; it is also known as the approximate ideal solution. It investigates the appropriate approach in terms of relative closeness based on their distances from the positive ideal solution (PIS) and the negative ideal solution (NIS), ensuring that the shortest distance from the PIS and the farthest distance from the NIS are satisfied.
is analysis method effectively eliminates decision information uncertainty while maintaining the validity and precision of decision-making by simply measuring the distance between PIS and NIS and ranking them accordingly. TOPSIS method is straightforward and simple to understand and analyze as compared to the ELECTRE method, VIKOR method, and other conventional methods, so it has been extensively studied and implemented by researchers.
In recent years, several authors have presented TOPSIS in various fuzzy information. For example, Boran et al. [38] used TOPSIS to identify the best supplier by using IF information. Chen and Tsao [39] suggested the TOPSIS technique based on interval-valued fuzzy information and addressed the experimental results. e authors in [40] established the extended TOPSIS method for q-ROHFSs and addressed their significance in DM. Li [41] proposed a TOPSIS-based nonlinear programming technique for MADM with interval-valued IFs in order to deal with uncertainty in real-world DM problems. e TOPSIS model for DM problems in interval-valued IF information was introduced by Park et al. [42]. e Dombi-based AOPs for PF information is formulated in [43]. Barukab et al. [44] 2 Complexity proposed the extended fuzzy TOPSIS method for spherical fuzzy information, which is based on the entropy measure. e aforesaid approach has been used by many other researchers; see [45][46][47] for more information. However, there are many research findings in applying the fuzzy TOPSIS method to solve MADM problems; the decision information used by these approaches is too old and restricted to manage increasingly challenging decision environments.
Pawlak [48] was the founder of exploring the dominating concept of rough set (RS) theory. e classical set theory which deals with inconsistent and imprecise information is extended by rough set theory. Recently, research on the rough set has progressed significantly, both in terms of theoretical implementations and theory itself. In recent decades, research has demonstrated the TOPSIS technique in a number of RS information. Su et al. [49] studied RS theory based on fuzzy TOPSIS on the serious game design assessment procedure. Khan et al. [50] implemented a rough set strategy and the TOPSIS method for selection of sites for food distribution. Lu and Zhao [51] investigated the improved TOPSIS method based on RS theory for selection of suppliers. A ♭−rough set model and its applications to DM using the TOPSIS approach have been discussed in [52]. e concept of RS has been expanded by several researchers around the world in different directions. Using the fuzzy relation rather than the crisp binary relation, Dubois and Prade [53] initiated the notion of fuzzy rough sets (FRSs). e hybrid structure of IFSs and RS, intuitionistic RS (IFR set), was introduced by Cornelis et al. [54]. Zhou and Wu [55] established a novel DM technique under the IFR environment to address their constructive and axiomatic analysis in detail by utilizing IFR approximations. Zhan et al. [56] presented the DM methodology under the IFR environment and explored their applications in real-world problems. Different extensions of the IFRS are being investigated [57,58] to tackle the uncertainty in MCGDM problems. Chinram et al. [59] established the algebraic norm-based AOPs based on the EDAS technique under IFR information and discussed their applications in MAGDM.
In some real-life circumstances, there exist numerous cases when decision makers (DMs) have their strong points of view about ranking or rating of plans, projects, or political statements of a government. For example, let the administration of a university start megaprojects of the football ground to render his accomplishment and performance. e members of the university administration may rate their project highly by assigning positive mem-bership� 0.9, whereas the others may rate the same project as a wastage of money and try to defame it by providing strongly opposite points of view. So, they assign negative membership� 0.7. In this situation, their sum 0.9 + 0.7 > 1 and (0.9) 2 + (0.7) 2 > 1 but (0.9) q + (0.7) q < 1 for q > 3 so that it is neither IFN nor PFN but it is q-ROFN.
us, Yager's q-ROFNs are efficient to deal with vagueness in the data. q-rung orthopair probabilistic hesitant fuzzy rough set (q-ROHFRS), a hybrid intelligent structure of rough sets and q-ROPHFS, is an advanced classification strategy that has attracted researchers to address ambiguous and incomplete data. From the analysis, it is concluded that, in decision-making, AOP plays a significant role in aggregating the collective data from different sources to a single value. In accordance with the best available knowledge to date, the development of the AOP with the hybridization of the q-ROPHFS with a rough set is not observed in the q-ROF setting. As a result, the current q-ROPHF rough structure is inspired, and we define a list of Einstein aggregation operators depending on rough data, such as qrung orthopair probabilistic hesitant fuzzy Einstein weighted averaging, Einstein ordered weighted averaging, Einstein hybrid weighted averaging, Einstein weighted geometric, Einstein ordered weighted geometric, and Einstein hybrid weighted geometric aggregation operators, under the Einstein t-norm and s-norm.
e description of the main objectives of the present work is as follows: (1) To introduce a novel idea of q-rung orthopair probabilistic hesitant fuzzy rough sets (q-ROPHFRSs) and investigate their basic operational laws. (2) Establish a list of AOPs based on Einstein t-norm and t-conorm and comprehensively explore the relevant properties.
(3) To develop a DM strategy for aggregating unpredictability in real-world DM problems employing suggested aggregation operators. (4) In addition, a case study of drug selection for mild COVID-19 symptoms is described to demonstrate the applicability and utility of the established operators. (5) Finally, a comparison with the q-ROPHFR-TOPSIS method is made to interpret the outcomes. e ranking of the obtained results is presented graphically.
Definition 1. (see [15]). For a universal set Ω, an FS Q is presented as for each x ∈ F, and the function β Q (x) belongs to [0, 1] that represent the degree of membership.
Definition 3. (see [60]). For a universal set Ω, an HFS A in Ω is represented mathematically as where β h A (x) is a set of some values in [0, 1] representing the degree of membership for the element x ∈ Ω of the set A.
Definition 4. For a universal set Ω, a probabilistic HF set (PHFS) P in Ω is described mathematically as where β h P (x) is a subset of [0, 1] and β h P (x)/ð x shows a membership grade of the element x ∈ Ω to the set P. And ð x shows the possibilities with the property that ⊕ s t�1 ð h t � 1.

Definition 5.
(see [31]). For a universal set Ω, a q-ROFS 5 over Ω is defined as for each x ∈ 5; the functions β 5 : Ω ⟶ 0, 1] and ψ 5 : Ω ⟶ 0, 1] denote the membership and nonmembership, respectively, which must satisfy (ψ 5 (x)) q + (β 5 (x)) q ≤ 1, (q > 2 ∈ Z) ( Figure 2). Definition 6. (see [33]). For a universal set Ω, the mathematical representation of q-ROHFS ℶ is as follows: where β h ℶ (x) and ψ h ℶ (x) are sets of some values in [0, 1]. It is required to satisfy the following properties: ∀x ∈ Ω, Definition 7. (see [33]). Let en, the basic set theoretic operations are as follows: be two q-ROHFNs where q > 2 and c > 0 are any real number. en, the operational laws based on Einstein t-norm and tconorm can be defined as 4 Complexity Definition 9. For a universal set Ω, a q-ROPHFS I is defined as where β h I (x)/ð x and ψ h I (x)/z x are sets of some values in [0, 1] which denote the membership and nonmembership, respectively. ð x and z x represent the possibilities of membership and nonmembership with the following property: 0 ≤ ð h t and z h t ≤ 1 with ⊕ p i�1 ð h t ≤ 1 and ⊕ p i�1 z h t ≤ 1 (p represents that the total elements exist in the q-ROPHFS). It is required to satisfy the following properties: ∀x ∈ Ω, ∀ϖ I (x) ∈ β h I (x), and ∀] I (x) ∈ ψ h I (x) with (max(β h I (x))) q + (min(ψ h I (x))) q ≤ 1 and (min(β h I (x))) q + (max(ψ h I (x))) q ≤ 1. For simplicity, we will use a pair I � (β h I /ð x , ψ h I /z x ) to mean a q-ROPHF number (q-ROPHFN).

10.
Let be two q-ROPHFNs. en, the basic set theoretic operations are as follows: Complexity be two q-ROPHFNs and q > 2∈∈Z + and c > 0 be any real number. en, the operational laws based on Einstein t-norm and tconorm can be defined as Definition 12. Let Ω be the universal set and ℵ⊆Ω × Ω be a (crisp) relation. en, , a) ∈ Ω, and (a, b) ∈ ℵ implies (g ∧ . , b) ∈ ℵ Definition 13. (see [48]). Let Ω be a universal set and ℵ be any relation on Ω. Define a set-valued mapping ) is called a successor neighborhood of the element g ∧ .
with respect to relation ℵ. e pair (Ω, ℵ) is called the (crisp) approximation space. Now, for any set ♭⊆Ω, the lower and upper approximation of ♭ with respect to the approximation space (Ω, ℵ) is defined as 6 Complexity ⊆♭ , (see [59]). Let Ω be the universal set and ℵ ∈ (Ω × Ω) be an intuitionistic fuzzy relation. en, Definition 15. Let Ω be the universal set. en, any ℵ ∈ q − RFS(Ω × Ω) is called a q-rung relation. e pair (Ω, ℵ) is said to be q-rung approximation space. Now, for any ♭⊆q − RFS(Ω), the upper and lower approximations of ♭ with respect to the q-RF approximation space (Ω, ℵ) are two q-RFSs, which are denoted by ℵ(♭) and ℵ(♭) and are defined as where , (15) such that As are upper and lower approximation operators. e pair is known as the q-rung rough set. For simplicity, is represented as ℵ(♭) � ((ϖ, ]), (ϖ, ])) and is known as q-RFRV.

Construction of q-Rung Orthopair Hesitant Fuzzy Rough Sets
In this section, we propose the notion of q-ROHFRS which is the hybrid structure of the rough set and q-ROFS. We also introduce the new accuracy and score functions to rank the q-ROHFRS and also put forward its basic operational laws.
For comparing/ranking two or more q-ROHFRVs, the score function will be utilized, whereas the accuracy function will be used when the score values are equal. e accuracy function will be used when the score values are equal.

Construction of q-Rung Orthopair Probabilistic Hesitant Fuzzy Rough Sets
is section deals with the notion of q-ROPHFRS which is the hybrid structure of the rough set and q-ROPHFS. We also establish the new score and accuracy functions to rank the q-ROPHFRS and also discuss the operational laws.
e score function for q-ROPHFRV is given as where M I and N I represent the number of elements in β h g and ψ h g , respectively.

q-Rung Orthopair Probabilistic Hesitant Fuzzy Rough Aggregation Operators
In this section, we propose a new idea of q-ROPHF rough AOPs by embedding the notions of the RS and q-ROPHF AOPs to get aggregation concepts of q-ROPHFREWA and q-ROPHFREWGA. Furthermore, some fundamental properties of the notion are discussed.

q-Rung Orthopair Probabilistic Hesitant Fuzzy Rough Einstein Weighted Averaging Operator
. . . , n) be the collection of q-ROPHFRVs. en, the q-ROPHFREWA operator is determined by where c � (c 1 , c 2 , . . . , c n ) T are the weight vector such that ⊕ n t�1 c t � 1 and 0 ≤ c t ≤ 1 and ð h t and z h t are probabilistic terms such that ⊕ n t�1 ð h t � 1 and ⊕ n t�1 z h t � 1.
. . . , n) be the collection of q-ROPHFRVs. en, the q-ROPHFREWA operator is defined by 10 Complexity Proof. We will prove the aforesaid theorem by utilizing mathematical induction. Suppose n � 2. en, and the result is true for n � 2. Now, suppose the result is true for n � k.
Next, we shall show that the result is true for n � k + 1.

Complexity
Hence, the result is true for n � k + 1.
(1) Idempotency: as for all t, (2) Boundedness: 14 Complexity and and let c � (c 1 , c 2 , . . . , c n ) T be the weight vector such that c t ∈ 0, 1] and ⊕ n t�1 c t � 1 and ð h t be the probabilistic term such that ⊕ n t�1 ð h t � 1; we have In a similar way, we can show that and let c � (c 1 , c 2 , . . . , c n ) T be the weight vector such that c t ∈ 0, 1] and ⊕ n t�1 c t � 1 and z h t be the probabilistic term such that ⊕ n t�1 z h t � 1; we have

q-Rung Orthopair Probabilistic Hesitant Fuzzy Rough Einstein Weighted Geometric Aggregation Operator
In this section, the q-ROPHFREWG aggregation operator is introduced, and the key characteristics of the proposed operators are demonstrated. 1, 2, 3, 4, . . . , n) be the collection of q-ROPHFRVs. en, q-ROPH-FREWGA operator is determined as where c � (c 1 , c 2 , . . . , c n ) T is the weight vector such that ⊕ n t�1 c t � 1 and 0 ≤ c t ≤ 1 and ð h t and z h t are probabilistic terms such that ⊕ n t�1 ð h t � 1 and ⊕ n t�1 z h t � 1.
be the collection of q-ROPHFRVs with the weight vector c � (c 1 , c 2 , . . . , c n ) T such that ⊕ n t�1 c t � 1 and 0 ≤ c t ≤ 1. en, the q-ROPHFREWG operator is described as Complexity where c � (c 1 , c 2 , . . . , c n ) T is the weight vector such that ⊕ n t�1 c t � 1 and 0 ≤ c t ≤ 1 and ð h t and z h t are probabilistic terms such that ⊕ n t�1 ð h t � 1 and ⊕ n t�1 z h t � 1.
Proof. We will prove the aforesaid theorem by utilizing mathematical induction. Suppose n � 2; then, and the result is true for n � 2. Now, suppose the result is true for n � k.
18 Complexity Furthermore, we are going to show that the result holds for n � k + 1.
Construct the experts' evaluation matrices as where J ∧ shows the number of experts.

Complexity 23
Evaluate the normalized experts' matrices if for the cost type.
e weight information of the attributes is determined by using the Shannon entropy measure in the following way. e entropy measure corresponding to each attribute is us, weights of attributes are found as Compute the q-ROPHFRVs for each considered alternative with respect to the given list of criteria/attributes by utilizing the proposed aggregation information.
Find the ranking of alternatives based on the score function as Rank all the alternative scores in the descending order.
e alternative having a larger value will be superior/best. e algorithm steps/flowchart of the decision-making technique are shown in Figure 3.

Numerical Example
To strengthen our developed operators, we consider a numerical MCGDM example of drug selection for the treatment of COVID-19. . Nowadays, an overwhelming majority of the world is fighting against an epidemic called coronavirus. Coronavirus is a new virus that has recently been identified in humans and is officially named COVID-19. Corona corresponds to the virus's external surface, which has crownlike spikes [61]. Common symptoms of infection are fever, cough, fatigue, shortness of breath, and breathing difficulties [12,[62][63][64][65]. Regularly washing hands and covering the nose and mouth while coughing or sneezing are standard suggestions for preventing infection spread.

Case Study (Drug Selection for the Treatment of
e COVID-19 virus is spread mostly by mouth droplets or nasal discharge when the infected individual coughs or sneezes. Avoid close contact with anyone who is coughing or sneezing and has respiratory symptoms. e moderate symptoms of COVID-19 infections are likely to be prevented by several known antiviral medications [66]. In the case of antiviral medications, up to now, there are no specific medicines developed for the disease. However, different medicines are used for experimental purposes to benefit COVID-19 patients, and laboratory testing indicates that any combination of drugs 24 Complexity could be effective against COVID-19. e combination of lopinavir/ritonavir and interferon-beta (LPV/RTV-IFNb) reduced viral masses slightly without impacting other clinical factors. Remdesivir (GS-5734), a nucleotide analog prodrug, was earlier tested for SARS, MERS, and Ebola [67]. Remdesivir has been demonstrated to be safe and beneficial for patients with mild COVID-19 symptoms, according to an experimental investigation [68]. Hydroxychloroquine (HCQ) and chloroquine (CQ) are widely used antimalarial drugs that stimulate immunomodulatory responses and also used to avoid autoimmune disorders. Wang et al. [69] testified that HCQ was found to be more stimulating than CQ in vitro. e potential effectiveness of these drugs in regulating cytokine discharge syndrome in patients has been investigated from the global pandemic of COVID-19. Even though there is no effective treatment for COVID-19, all antiviral medicines should be investigated further in clinical testing. According to a WHO report released on June 13, 2021, more than 176,396,104 cases of COVID-19 have been reported worldwide, resulting in more than 3,810,989 deaths. A total of 160,398,032 people have been recovered [2]. e most common symptoms and signs reported by COVID-19 patients are fever (83%-99%), shortness of breath (31%-40%), fatigue (44%-70%), anorexia (40%-84%), cough (59%-82%), sputum production (28%-33%), and myalgia (11%-35%) [70][71][72][73][74].
Here, we proposed four medicines as alternatives for the treatment of COVID-19 patients, namely, LPV/RTV-IFNb (A 1 ), remdesivir (A 2 ), LPV/RTV (A 3 ), and favipiravir (A 4 ). Antiviral medications should be selected not only for their effect on symptoms but also for their effectiveness and possible side effects. erefore, we take four parameters, cough (χ 1 ), fatigue (χ 2 ), fever (χ 3 ), and shortness of breath (χ 4 ). For selection of optimal medicine, information is presented as q-ROPHFR information. e corresponding weight vector for criteria is c � (0.13, 0.27, 0.29, 0.31) T . e following computations are performed to address the MCDM problem using the established methodology for evaluating alternatives. e information of the professional expert is given in Tables 1 and 2 in the form of q-ROPHFRS. e expert information is of the benefit type. So, in this case, we do not need to normalize the q-ROPHFRVs.
In this problem, only one expert is considered for collection of uncertain information. So, we do not need to find the collected information.
Aggregation information of the alternative under the given list of attributes is evaluated using proposed aggregation operators which are as follows.
Case 1. Aggregation information using the EWA operator is shown in Table 3.
Case 2. Aggregation information using the q-ROHFREWG operator is presented in Table 4.

Complexity
Score values of all alternatives under developed AOPs are presented in Table 5.
From the above computations, we concluded that alternative A 2 is the finest alternative among others, and therefore, it is highly recommended (Figure 4).

Reliability and Validity Test
In practice, selecting the perfect option from the group's decision matrices is a challenging task. e approach for analyzing the reliability and validity of DM systems was developed by Wang and Garg [75]. e testing procedure is as follows: Test step 1: if we substitute the normalized element for the worse element of the alternative by presenting the appropriate alternative with no modification and also with no altering the comparable position of each decision criterion, the appropriate and effective MAGDM technique is to do so. Test step 2: the transitive property must be satisfied using an efficient and appropriate MAGDM approach. Test step 3: when a MAGDM problem is reduced to a minor one, a combined alternative rating should be similar to the original rating of the undecomposed problem. To rank the alternative, we utilize the same methods adopted in the MAGDM problem on minor issues. e MAGDM problem was reduced to a smaller one in order to achieve the best result, and the same suggested DM technique has been used. e appropriate and effective MAGDM technique is that if we apply the same procedure to a small problem, the result would be the same as the MAGDM problem.

Validity Test for the Proposed DM Methodology.
Utilizing the competency of the aforementioned test, we check the appropriation and validation of our established approach (Tables 7 and 8). e q-ROPHFR information is enclosed in Tables 9 and 10 as follows: Test step 1: we substitute the worse element of the alternative by presenting the appropriate alternative with no modification and also with no altering the comparable position of each decision criterion, in this step. Table 11 encloses the updated decision matrix. Now, we calculate the combined values of each alternative under criteria weight (0.13, 0.27, 0.29, 0.31) T using the proposed list of q-rung orthopair probabilistic hesitant fuzzy rough aggregation operators as follows: Case I: aggregated information using q-ROPHFRWA operators is enclosed in Table 12. Case II: aggregated information using q-ROPHFRWG operators is enclosed in Table 13.
Score values of all alternatives under developed aggregation operators are presented in Table 13.
We get again the same alternative A 2 by using test step 1, which is also obtained by applying our proposed method.
We are now testing the validity test steps 2 and 3 to demonstrate that the proposed approach is reliable and relevant. To this end, we first transformed the MAGDM problem into three smaller subproblems such as A 2 , A 1 , A 4 , A 1 , A 4 , A 3 , and A 2 , A 4 , A 3 . We now implement our suggested decision-making approach to the smaller problems that have been transformed and give us the ranking of alternatives as 3 is the same as the standard decision-making approach results when assigning detailed ranking ( Figure 5).

TOPSIS Methodology Based on q-Rung Orthopair
Probabilistic Hesitant Fuzzy Rough Information. Hwang and Yoon proposed the TOPSIS technique for the ideal solution, which allows policymakers to compare the PIS and NIS. TOPSIS is based on the assumption that the best alternative would be the closest to the ideal and the furthest away from the perfect negative solution [76,77]. e main parts of the method are as follows.
Let ♭ � A 1 , A 2 , A 3 , . . . , A n be the set of alternatives and C � χ 1 , χ 2 , χ 3 , . . . , χ n be a set of criteria. e decision matrix of the expert is presented as Complexity     Table 5: Score values.

Complexity
where t � 1, 2, 3, . . . , n and j � 1, 2, 3, . . . , m. e relative closeness indices for all DMs of the alternatives are calculated as follows: e ranking orders of alternatives can be determined, and the most desirable alternative having minimum distance is chosen.

Implementation of the Methodology
A numerical example relevant to "drug selection for the treatment of COVID-19 disease" is given below to validate the usefulness of our approach. e DM information in the form of q-ROPHFRNs is given in Tables 1 and 2. PIS and NIS are computed in Table 13.
Compute the distance measure of the PIS and NIS. From ranking of the alternative, it could be seen that A 2 has the minimum distance ( Figure 6). Hence, A 2 is the best alternative (Tables 15-17).

Conclusion
e main objective of this research is to present a unique and new approach for evaluating the medicine selection problem for COVID-19 infection utilizing the novel concepts of q-ROPHFRS under the q-ROFS, HFS, and RS environment. In comparison to conventional fuzzy models, a q-ROPHFR model effectively describes real-world problems with ambiguity, vagueness, and incompleteness. Furthermore, we introduced the concept of q-ROPHFREWA and q-ROPHFREWG aggregation operators that are effective and flexible to MCGDM problems with uncertainty. Furthermore, the efficiency and applicability of the described notion have been presented by evaluating medications for the patients infected by the COVID-19 virus. In the final ranking and optimal decision-making of treatments for patients of COVID-19 virus, the proposed techniques are compared with the q-ROHFR-TOPSIS method, and the superiority of the acquired results is validated. e ranking of the alternatives is depicted graphically. According to the final ranking of the established methodology, remdesivir is the most effective medicine for treating patients infected with COVID-19.
It is observed that some essential topics remain in terms of potential future works that are good enough to justify. In the future, this work will be extended to the (1) q-ROPHFRE ordered weighted averaging operator (WAO); (2) q-ROPHFRE hybrid AOPs; (3) q-ROPHFRE ordered weighted geometric operator (WGO); and (4) q-ROPHFRE hybrid WGO.

Limitation.
A number of included studies were limited in terms of data availability and methodological quality.
erefore, the reported findings should be interpreted cautiously within that context. Furthermore, our study was limited to the articles published in English. Considering the epicenter of COVID-19, Chinese literature should be included in future systematic reviews. We will continue to monitor the literature, and this method will be updated when new evidence emerges.
Data Availability e data used in the manuscript are hypothetical and can be used by anyone by just citing this article.

Conflicts of Interest
e authors declare no conflicts of interest about the publication of the research article.