Bortezomib Use for a Critically Ill Patient with Angioimmunoblastic T-Cell Lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) accounts for 18.5% of all peripheral T-cell lymphomas. There is still no gold standard chemotherapy for treating newly diagnosed AITL. This case describes the use of bortezomib in newly diagnosed AITL. A 53-year-old man with no previous illness presented with erythema and swelling in the left neck. A diagnosis of AITL was made based on the results of lymph node biopsies. AITL progression led the patient to a severely deteriorated general condition. Bortezomib was thus administered, which resulted in a reduction in lymphadenopathies, the disappearance of tumor fever, and a decrease in serum lactate dehydrogenase levels. Subsequently, the patient's general condition gradually improved. Despite the patient's poor condition, bortezomib was well tolerated. After bortezomib administration, the patient did not require chemotherapy for approximately 10 months. The present case indicates that bortezomib is a possible treatment option for patients with AITL.

To date, there is no gold standard chemotherapy for treating newly diagnosed AITL. AITL is usually treated with the CHOP regimen, which includes cyclophosphamide, doxorubicin, vincristine, and prednisone; CHOEP, which includes etoposide in addition to CHOP; and ACVBP, which includes doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone. [3].
Bortezomib is an anticancer drug that inhibits the proteasome, inducing the accumulation of unfolded and misfolded proteins, which in turn leads to apoptosis and cell death. In addition, bortezomib inhibits the production of cytokines such as IL-6, insulin-like growth factor-1, and VEGF in bone marrow stromal cells. [7] Bortezomib is also an effective agent for the treatment of B-cell neoplasms, such as multiple myeloma, mantle cell lymphoma, and lymphoplasmacytic lymphoma. [7,8] Moreover, several previous studies have reported the efficacy of bortezomib for the treatment of T-cell neoplasms. [9][10][11].
is case report describes the successful use of bortezomib in a critically ill patient with AITL.

Case Presentation
A 53-year-old man with no previous illness presented with erythema throughout the body 4 weeks before and with swelling in the left neck 6 weeks before admission to our hospital. e patient was admitted to another hospital 18 days before admission to our hospital. A whole-body computed tomography (CT) revealed lymphadenopathies and a ground-glass appearance in the lung. His soluble IL-2 receptor level was 5,445 U/mL. Prednisolone (PSL) administration was started at a dose of 30 mg daily. A left axilla lymph node biopsy was performed on the fourth day after another hospital admission. en, the patient was transferred to our hospital. e clinical course after admission to our hospital is summarized in Figure 1. On the first hospital day, his consciousness was clear. His vital signs were as follows: body temperature, 38.3°C; blood pressure, 162/ 97 mmHg; pulse rate, 122 beats/min; and oxygen saturation, 91% in ambient air. Moreover, his Eastern Cooperative Oncology Group (ECOG) performance status was 1, and his Karnofsky scale score [12] was 80 points. Erythema in the face, arms, and trunk and palpable lymphadenopathies in the bilateral cervical and left axilla areas were noted. Regarding B symptoms, the patient had a fever of >38°C but no drenching night sweats or unintentional weight loss. Laboratory tests on admission revealed leukocytosis (white blood cell count, 28,800/µL) with an increase in the level of eosinophils (17.0%) and plasma cells (11.0%); anemia (hemoglobin level, 10.0 g/dL); decreased percentage of reticulocytes (2.0%); elevated serum levels of lactate dehydrogenase (LDH) (991 IU/L), creatinine (1.56 mg/dL), and C-reactive protein (4.75 mg/dL); and polyclonal gammaglobulinemia (immunoglobulin (Ig) G, IgA, and IgM levels were 5,366 mg/dL, 378 mg/dL, and, 660 mg/dL, respectively). Serum and urinary protein electrophoresis did not reveal a localized band. A clonally rearranged Ig heavy chain JH gene was not detected. Whole-body CT showed lymphadenopathies in the bilateral cervical, subclavian, axillary, mediastinal, para-abdominal aortic, and bilateral inguinal regions; splenomegaly; and a ground-glass pattern in both lungs. A bone marrow examination was performed and it revealed no evidence of malignant cell invasion. However, flow cytometry analysis revealed an increase in the level of plasma cells (accounting for 25.8% of all nucleated cells) with no restriction of light chains. e dosage of PSL was up to 80 mg on the first hospital day, but the treatment was switched to dexamethasone at a dose of 40 mg daily for 3 days on the second hospital day because PSL failed to improve the lymphadenopathies. Biopsy of the left axillary lymph nodes was performed again on the fourth hospital day. A diagnosis of AITL accompanied by reactive plasmacytosis was made based on the results of the two lymph node biopsies and other aforementioned tests.
e Ann Arbor stage was IIIB. e international prognostic index was  Case Reports in Hematology high-intermediate risk. Treatment with subcutaneous administration of bortezomib at a dose of 1.3 mg/m 2 was started on the fourth hospital day, but the patient experienced chest discomfort on the fifth hospital day. Electrocardiography showed an elevated ST segment elevation in aVf and V2-V4. e patient's serum creatine phosphokinase-MB level was increased to 115 IU/L. ese findings led to a diagnosis of acute myocardial infarction (AMI). e patient was admitted to the intensive care unit. Percutaneous coronary angioplasty was performed, and antiplatelet therapy with aspirin at a dose of 200 mg and prasugrel at a dose of 20 mg daily and anticoagulant therapy with intravenous administration of heparin were started. An intraaortic balloon pump was introduced. Chemotherapy with bortezomib was temporarily discontinued. Chest radiography showed shadows in both lungs, which were extended on the seventh hospital day. On the 11th hospital day, the patient experienced respiratory failure, resulting in the need for artificial respiration followed by prone positioning. Bronchoscopy was performed, which revealed that there were no mucosal abnormalities, lesions, or obstructions in the airways. Serial bronchoalveolar lavage was performed with the sequential administration of normal saline. e return was erythematous effluent. Based on the bronchoscopy and chest radiography findings, a diagnosis of respiratory failure due to alveolar hemorrhage was made. Subsequently, antiplatelet therapy was discontinued, but heparin administration was continued because the coronary artery thrombus remained. An artificial cardiac pacemaker was inserted because of the onset of atrioventricular block. On the 14th hospital day, the patient's consciousness level dropped to Glasgow coma scale E 4 M 4 M 5 . A fever of 39.2°C developed and his ECOG performance status increased to 4. His Karnofsky scale score decreased to 10 points. e patient required noradrenaline administration for hypotension and hemodialysis for acute renal failure secondary to hypotension. e patient received steroid pulse therapy with methylprednisolone at a dose of 1,000 mg for 3 days for alveolar hemorrhage, followed by PSL administration. However, the patient's general condition severely deteriorated, and he required chemotherapy because the developing fever was considered tumor fever secondary to AITL recurrence.
erefore, five doses of bortezomib were administered, following which the tumor fever disappeared and his serum LDH level decreased. On the 20th hospital day, the patient no longer required artificial respiration only hemodialysis. Compared with the CT scans of the 13th hospital day, those of the 30th hospital day showed a reduction in lymphadenopathies (<50% reduction), and the size of the splenomegaly remained the same. e patient's general condition gradually improved. On the 135th hospital day, the patient was discharged and followed up as an outpatient thereafter. After discharge from the hospital, approximately 1 month later, positron-emission tomography revealed 18 F-fluorodeoxyglucose uptake in the lymph nodes as follows: bilateral cervical region (maximum standardized uptake value [SUV max], 7.5), around the stomach on the lesser curvature side (SUV max, 6.02), and paraabdominal aortic region (SUV max, 8.76). us, there were lymphadenopathies with 18 F-fluorodeoxyglucose uptake as revealed via positron-emission tomography, but they had not progressed. erefore, the patient did not require chemotherapy for approximately 10 months. However, lymphadenopathies progressed thereafter. e patient had received cytotoxic chemotherapy and died of AITL progression approximately 10 months after starting cytotoxic chemotherapy.

Discussion
Bortezomib is known to be effective for the treatment of B-cell neoplasms. [7,8] Moreover, several clinical and in vitro studies have demonstrated the efficacy of bortezomib in the treatment of T-cell neoplasms, as described below.
Regarding the safety of using bortezomib for AITL treatment, a previous phase 2 study reported the outcomes of CHOP therapy plus bortezomib use for the treatment of peripheral T-cell lymphoma. [13] e study was conducted in 46 previously untreated patients with peripheral T-cell lymphomas, including 8 patients with AITL. Twenty-nine patients completed the planned treatment schedule (median number of cycles: 6), and the response was assessed in 44 patients because 2 patients dropped out early as they developed grade 4 hepatic dysfunction and pneumonia. Grade 3-4 leucopenia (common terminology criteria for adverse events (CTCAE) ver 3.0) was the most frequent adverse event, whereas neurotoxicity was tolerable (grade 1-2 peripheral neuropathy). e findings pertaining to the present case suggest the safety of using bortezomib for the treatment of T-cell lymphomas, where the only adverse effect was leukopenia grade 1 (CTCAE ver 5.0). e patient developed AMI the day after bortezomib administration, but it is speculated that AMI was caused by hypercoagulation associated with the administration of a high dose of dexamethasone. Furthermore, the most noteworthy aspect was that chemotherapy with bortezomib was well tolerated despite the patient's severely deteriorated condition.
ere are two case reports of bortezomib use in patients with AITL (Table 1). [14,15] In Case 1, similar to that in our case, bortezomib was used in combination with steroids, which resulted in a reduction in lymphadenopathies. e clinical effectiveness of bortezomib was indicated. In Case 2, because bortezomib was used in combination with other anticancer drugs, it is not clear whether bortezomib was effective for AITL. In our case, the patient did not require chemotherapy for 10 months. is clinical course indicates that bortezomib is a possible treatment option for patients with AITL.

Conclusion
e present case indicates that bortezomib is a possible treatment option for patients with AITL. Furthermore, it may be well tolerated, even if the patient's general condition deteriorates.

Conflicts of Interest
e authors declare that there are no conflicts of interest.