Case Reports in Infectious Diseases
Volume 2017 (2017), Article ID 8682354, 4 pages
https://doi.org/10.1155/2017/8682354

Case Report

Prosthetic Joint Infection due to Mycobacterium avium-intracellulare in a Patient with Rheumatoid Arthritis: A Case Report and Review of the Literature

Nicholas E. Ingraham,¹ Brenton Schneider,² and Jonathan D. Alpern³

¹Department of Internal Medicine, University of Minnesota, Minneapolis, MN, USA
²Department of Internal Medicine, Hennepin County Medical Center, Minneapolis, MN, USA
³Department of Infectious Disease, University of Minnesota, Minneapolis, MN, USA

Correspondence should be addressed to Nicholas E. Ingraham; nicholas.ingraham@gmail.com

Received 26 September 2016; Accepted 24 January 2017; Published 9 February 2017

Academic Editor: Tomoyuki Shibata

Copyright © 2017 Nicholas E. Ingraham et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Nontuberculous mycobacteria (NTM) are a rare cause of prosthetic joint infections (PJI). However, the prevalence of NTM infections may be increasing with the rise of newer immunosuppressive medications such as biologics. In this case report, we describe a rare complication of immunosuppressive therapies and highlight the complexity of diagnosing and treating PJI due to NTM. The patient is a 79-year-old Caucasian male with a history of severe destructive rheumatoid arthritis on several immunosuppressive agents and right hip osteoarthritis s/p total hip arthroplasty 15 years previously with several complex revisions, presenting with several weeks of worsening right hip and abdominal pain. A right hip CT scan revealed periprosthetic fluid collections. Aspiration of three fluid pockets was AFB smear-positive and grew Mycobacterium avium-intracellulare. The patient was deemed a poor surgical candidate. He underwent a limited I&D and several months of antimycobacterial therapy but clinically deteriorated and opted for hospice care. PJI caused by NTM are rare and difficult to treat. The increased use of biologics and prosthetic joint replacements over the past several decades may increase the risk of PJI due to NTM. A high index of suspicion for NTM in immunosuppressed patients with PJI is needed.

1. Introduction

A 79-year-old man with a history of a right total hip arthroplasty (THA) performed 15 years prior to admission was admitted with 3 weeks of right hip pain. His history was notable for severe rheumatoid arthritis (RA), Alzheimer’s dementia, coronary artery disease, and several arthroplasty revisions, which were performed 10 and 5 years prior to admission due to dislocations. His RA had been treated with prednisone 15 mg daily, leflunomide 10 mg daily, and infliximab. Six months prior to admission infliximab was replaced with abatacept 500 mg every month.

At presentation, vital signs were normal. BMI was 22.9 kg/m. He had right lower quadrant tenderness and pain with internal/external rotation of the right lower extremity. His WBC count was within normal limits. The CRP was 5.2 mg/L (normal < 3 mg/L) and ESR was 28 mm/h (normal < 15 mm/h). A CT scan of the abdomen and pelvis revealed complex fluid collections involving the right hip, buttock, and iliac fossa (see Figure 1). A joint aspirate contained 2734 cells/μL WBC with 89% neutrophils. Aspirates from his joint and fluid collections were sent for Gram stain and culture, AFB smear and culture, and fungal cultures. Blood cultures were not sent. The AFB smears from each joint and fluid collection resulted positive for acid fast bacilli. The interferon gamma release assay (Quantiferon Gold) was indeterminate. HIV was not checked. His immunosuppression was adjusted, and leflunomide and abatacept were replaced with methotrexate and hydroxychloroquine. On day 14, mycobacterial cultures speciated as Mycobacterium avium-intracellulare (MAI). Rifampin, ethambutol, and clarithromycin were started.

(a)

(b)

(c)

(d)

Figure 1: CT abdomen. (a) Coronal cross section demonstrating a right hip complex fluid collection. (b) Right posterior iliac fossa fluid collection. (c) Right anterior iliac fossa fluid collections. (d) Transverse section demonstrating right buttock fluid collection.

A staged arthroplasty revision was not considered due to his comorbidities. Instead, he underwent extensive incision and drainage (I&D) of the joint and surrounding tissues, with percutaneous drain placement into the fluid collections. On discharge, he was continued on antimycobacterials for chronic suppression. After 4 months of therapy with ethambutol, clarithromycin, and rifampin, he continued to have positive AFB smears from the surgical site and percutaneous drains. After several months of declining quality of life, he was placed on hospice and died 6 months after initial presentation.

2. Discussion

MAI (M. avium and M. intracellulare) are slow growing mycobacteria that typically cause human disease in the form of pulmonary infection among immunocompetent hosts, disseminated infection in the setting of HIV/AIDS, and cervical lymphadenitis [1]. Mycobacteria are a rare cause of prosthetic joint infection (PJI), making up 0–0.6% of cases, with the majority of these caused by M. tuberculosis [2, 3]. In one retrospective study of PJI caused by rapidly growing mycobacteria (RGM), only eight cases were identified over a 38-year time period, with the majority of cases occurring in immunocompetent hosts [4]. In contrast, PJI due to MAI occurs most often in immunocompromised hosts and is significantly rarer (see Table 1) [2, 5–10]. To the best of our knowledge, this is the 7th reported case of PJI due to MAI and the first case in which the predisposing factor was immunosuppression due to antirheumatic medications.

Table 1: Prosthetic joint infections caused by Mycobacteriumavium species.

Citation
Age/gender
Pathogen
Site
Reason for arthroplasty
Predisposing factors
Time to symptom onset
Surgical treatment
Medical treatment
Outcome

[5]
67/F
MAC
Hip
DJD
Renal transplant on cyclosporine, prednisone
15 yrs after arthroplasty
 13 yrs after transplant
I&D, removal of prosthesis, spacer placement
 Repeat I&D and spacer removal for sterile wound drainage 4 months post-op
Azithromycin, ethambutol, rifabutin
Planned reimplantation at 6 months and antimycobacterial coverage for total of 18 months

[6]
41/M
MAI (disseminated)
Knee
Salmonella septic arthritis
Suspected underlying immunodeficiency syndrome
 Polymyositis on prednisolone
15 mo after TKR (MRSA isolated after TKR)
Repeat debridements
Multiple antibiotic regimens
Died due to sepsis with MRSA, E.coli, K.pneumoniae, MAI, Candida 7 months after initial MAI culture

[7]
NR
M. avium
Hip
Osteonecrosis
Heart transplant on cyclosporine, prednisone
NR
None
Ethambutol, rifampin, isoniazid
Doing well at time of follow-up (time NR)

[8]
20/M
MAC (disseminated)
Bilateral hips
Perthes disease
AIDS
20 yrs after arthroplasty
4 yrs after HIV diagnosis
Right hip resection arthroplasty
Ciprofloxacin, clarithromycin, rifampicin, clofazimine
Died 5 months post-op

[9]
73/M
MAI (disseminated)
Knee
DJD
Multiple myeloma on lenalidomide, dexamethasone
 RA on methotrexate
 Previous pulmonary and olecranon MAC infections
3 yr after chemotherapy,
 1 yr after arthroplasty
Resection arthroplasty (reimplantation 7 mo post-op)
Clarithromycin, ethambutol
Doing well at 7 years of follow up

[10]
39/M
MAI (disseminated)
Hip
Osteonecrosis
Renal transplant
NR
Resection arthroplasty
Azithromycin, ethambutol > 12 mo; did not tolerate rifabutin
No recurrence on ethambutol, clarithromycin; reimplantation of prosthesis not performed

DJD, degenerative joint disease; I&D, incision and drainage; MAC, Mycobacteriumavium complex; MAI, Mycobacteriumavium-intracellulare; mo, months; MRSA, methicillin-resistant S. aureus; NR, not reported; PCP, Pneumocystis carinii pneumonia; TKR, total knee replacement; yrs, years.

In this patient, mycobacteria were likely introduced during a THA revision and persisted for years prior to disease onset in the setting of exogenous immunosuppression [11]. TNF-alpha antagonists, particularly infliximab, predispose patients to mycobacterial infections by blocking macrophage activation and intracellular killing [12]. The patient had risk factors both for PJI in general (RA, exogenous immunosuppressive medications) and for mycobacterial infection specifically, due to the use of multiple disease-modifying antirheumatic drugs (DMARDs). The use of oral corticosteroids and certain DMARDs such as TNF-alpha inhibitors and leflunomide increases the risk of both tuberculous and nontuberculous mycobacterial infections among patients with RA [13]. Abatacept has been associated with tuberculosis; however whether or not the drug is a risk factor for mycobacterial infection is unclear [14].

Making the diagnosis of NTM PJI requires obtaining mycobacterial cultures from clinical specimens in immunosuppressed patients at risk for NTM. Optimal management relies on experience from pulmonary MAI and PJI due RGM. A prolonged course of three drugs (macrolide, ethambutol, and rifampin) is recommended, in addition to surgical debridement or surgical excision [15]. Susceptibilities should be obtained to guide therapy. A case series of patients with PJI due to RGM suggested that resection arthroplasty with appropriate antimycobacterial drugs resulted in the best chance for cure. If debridement with prosthesis retention is performed, prolonged and indefinite antimycobacterial drugs are likely needed to prevent relapse [2, 4, 16]. Similar to PJI caused by rapid-growing NTM species, the prognosis for slow growing NTM PJI is variable (see Table 1).

In conclusion, MAI is a rare cause of PJI, occurring almost exclusively in immunocompromised patients. Among patients with PJI taking DMARDs or other immunosuppressive biologic medications, a high index of suspicion is needed for opportunistic infections such as MAI. Ensuring multiple intraoperative specimens is sent for AFB smear/culture is imperative for diagnosis.

Competing Interests

The authors declare that there is no conflict of interests regarding the publication of this paper.

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