Salmonella infection can cause a wide range of presentations, predominantly gastrointestinal but occasionally with cardiovascular or other extraintestinal manifestations. The diagnosis of extraintestinal salmonellosis requires a high degree of clinical suspicion and should be considered in patients with deep-seated abscesses especially if they are immunocompromised. We present a case of salmonella causing gastroenteritis complicated by an intramuscular abscess of the left leg. With prompt recognition and multidisciplinary management, the patient recovered with no serious sequela.
Salmonella infection can cause a wide range of presentations especially in immunocompromised hosts. In this case, we describe a 55-year-old Chinese Singaporean man, who presented with acute onset of nonbilious and nonbloody vomiting with diarrhoea and left leg pain. He was found to have gastroenteritis caused by
A 55-year-old Chinese Singaporean man with a background of Polycythemia Rubra Vera (PRV), currently on treatment with hydroxyurea and anagrelide, diabetes mellitus, and hypertension, was admitted with a four-day history of nonbilious, nonbloody vomiting accompanied with nonbloody diarrhea. This was associated with fever and also left leg pain and swelling. He had no other infective symptoms including cough, sputum production, or dysuria.
Physical examination revealed pyrexia (temperature: 38.9 degrees Celsius), blood pressure of 140/60 mmHg, and pulse rate of 80/min. His left calf was erythematous, swollen, warm, and tender. His abdomen was soft and nontender with no bruits. No pitting oedema was present. Routine blood investigations showed normal inflammatory markers and biochemistry (Table
Initial blood test results.
Test | Results | Unit | Reference interval |
---|---|---|---|
White blood cell | 7 | ×109/L | 3.40–9.60 |
Red blood cells | 3.06 | ×1012/L | 3.70–9.60 |
Haemoglobin | 10.9 | g/dL | 10.9–15.1 |
Mean cell volume | 105.6 | fL | 80.0–95.0 |
Mean corpuscular haemoglobin | 35.6 | pg | 27.0–33.0 |
Mean corpuscular haemoglobin Concentration | 33.7 | g/dL | 32.0–36.0 |
Haematocrit | 32.3 | % | 32.7–44.4 |
Platelets | 941 | ×109/L | 132–372 |
Mean platelet volume | 11.7 | fL | 8.7–12.2 |
Red cell distribution width | 17.8 | % | 11.4–14.8 |
Sodium | 135 | mmol/L | 135–145 |
Potassium | 4.0 | mmol/L | 3.5–5.0 |
Chloride | 99 | mmol/L | 95–110 |
Carbon dioxide | 23 | mmol/L | 22–31 |
Creatinine | 113 | umol/L | 50–90 |
Urea | 7.3 | mmol/L | 2.0–6.5 |
Glucose | 8.6 | mmol/L | 4.0–7.8 |
Albumin | 38 | g/L | 38–48 |
Bilirubin, total | 2 | umol/L | 5–30 |
Bilirubin, conjugated | 1 | umol/L | 0–5 |
Aspartate aminotransferase | 40 | U/L | 10–50 |
Alanine aminotransferase | 35 | U/L | 10–70 |
Alkaline phosphatase | 99 | U/L | 40–130 |
Lactate dehydrogenase | 693 | U/L | 250–580 |
Calcium, total | 2.30 | mmol/L | 2.15–2.55 |
C-reactive protein | 125 | mg/L | 0–10 |
Blood culture | Drugs | Susceptibility | MIC |
---|---|---|---|
Blood culture grew Salmonella Group C | Ampicillin | Sensitive | ≤2 mg/L |
Ceftriaxone | Sensitive | ||
Ciprofloxacin | Resistant | 0.500 mg/L | |
Cotrimoxazole | Sensitive | 40.00 mg/L |
Stool culture | Drugs | Susceptibility | MIC |
---|---|---|---|
Stool culture grew Salmonella Group C | Ampicillin | Sensitive | ≤2 mg/L |
Ceftriaxone | Sensitive | ||
Ciprofloxacin | Resistant | 0.380 mg/L | |
Cotrimoxazole | Sensitive | ≤20 mg/L |
Stool culture | Drugs | Susceptibility | MIC |
---|---|---|---|
Stool culture grew Salmonella Group B | Ampicillin | Resistant | ≥32 mg/L |
Ceftriaxone | Resistant | >256.000 | |
Ciprofloxacin | Sensitive | 0.008 | |
Cotrimoxazole | Sensitive | ≤20 mg/L | |
Azithromycin | sensitive | 4.000 |
He was started on intravenous ceftriaxone and subcutaneous low molecular weight heparin (LWMH) for deep venous thrombosis.
However, he had persistent fever and became hypotensive on the 10th hospital day. Repeat blood cultures grew Group C
Magnetic Resonance Imaging (MRI) of the left lower limb was performed. It showed a multiloculated collection with enhancing rim and septa centered within the tibialis posterior muscle, measuring approximately 13.9 × 4.4 × 4 cm with adjacent myositis and fasciitis (Figures
Axial, T2 weighted, fat saturated, STIR MR image showing loculated fluid signal within the tibialis posterior muscle (thick white arrows), suggestive of a collection. Also noted are diffuse T2 hyperintense signal changes in the surrounding musculature (thin white arrows), compatible with myositis.
Coronal, T2 weighted, fat saturated, STIR MR image showing loculated fluid signal within the tibialis posterior muscle (thick white arrows), suggestive of a collection. Also noted are diffuse T2 hyperintense signal changes in the surrounding musculature (thin white arrows), compatible with myositis.
T2 weighted, fat saturated, postcontrast, axial MR image of left calf showing a multiloculated fluid collection with associated enhancing rim and septations (white arrows) within the tibialis posterior muscle, compatible with an intramuscular abscess.
T2 weighted, fat saturated, postcontrast, axial MR image of left calf at another location, again showing a multiloculated fluid collection with associated enhancing rim and septations (white arrows) within the tibialis posterior muscle, compatible with an intramuscular abscess.
T2 weighted, fat saturated, postcontrast, coronal MR image of left calf showing a multiloculated fluid collection with associated enhancing rim and septations (white arrows) within the tibialis posterior muscle, compatible with an intramuscular abscess.
He was referred to orthopaedics for incision and drainage. Intraoperatively, a multiloculated intramuscular abscess in posterior tibialis muscle was observed; 15 mls of frank pus was drained. Two drains were inserted, with the inferior drain at the residual space of the posterior tibialis muscle and superior drain into the space between the posterior tibialis and soleus. Intraoperative pus culture grew Group B
His condition improved dramatically following the drainage with resolution of pyrexia and hypotension. IV ceftriaxone was continued for a total duration of six weeks with oral metronidazole. LWMH was administered for six weeks as well. He remained well six months after discharge.
Typhoid fever, caused by
Enteric fever is caused by
Transmission usually occurs by the oral-faecal route [
In microbiology laboratories, salmonellae are now rapidly identified using automated systems [
Salmonella infection of the thigh has previously been reported but in association with a pseudoaneurysm of the femoral artery [
Current literature regarding epidemiology of extraintestinal salmonellosis in immunocompromised patients remains scarce. A Malaysian study on NTS bacteraemia found that 55 out of 56000 blood cultures collected over four years grew NTS. An extraintestinal focus was found in 30% of cases, most commonly the lung and soft tissues (7.3% each). The study also described higher mortality in immunocompromised patients (30.6% versus 5.3% in immunocompetent patients) [
Atherosclerosis and HIV infections are the most common predisposing factors for systemic salmonella infections [
Warning signs of extraintestinal infection would include localized tenderness in the musculoskeletal system, pleuritic pain suggesting a pleural pathology, chest pain, or embolic phenomena suggesting a mycotic aneurysm.
In our patient, despite adequate treatment of his salmonella bloodstream infection and his deep vein thrombosis with ceftriaxone and LWMH, he became hypotensive and it was only with drainage of his intramuscular abscess that his condition began to improve.
It is important that physicians be alert for timely diagnosis of extraintestinal salmonella infections, especially in immunocompromised patients with the risk of complications which may be potentially fatal [
The diagnosis of extraintestinal salmonellosis necessitates a high degree of clinical suspicion. The majority of individuals with immunocompromised immune systems present with extraintestinal infections. A multidisciplinary approach is needed to treat immunocompromised patients with extraintestinal salmonella infections and abscesses.
Dr. Veeraraghavan Meyyur Aravamudan, Dr. Phang Kee Fong, Dr. Jong Sze Chin, Dr. Yang Shiyao Sam, Dr. Pavel Singh, and Dr. P. A. Tambyah have no disclosures to make directly related to the study and no conflicts of interest and no funding was received for the preparation of this manuscript. Dr. Tambyah has received research support from GSK, Sanofi-Pasteur, and Janssen in the last six months.
Veeraraghavan Meyyur Aravamudan, Phang Kee Fong, Jong Sze chin, and Yang Shiyao Sam helped in the compilation of the text and literature search. Pavel Singh helped in radiological images and literature search. P. A. Tambyah helped in the compilation of the text, literature search, and editing the manuscript.