Case Reports in Medicine
Volume 2018 (2018), Article ID 3258141, 5 pages
https://doi.org/10.1155/2018/3258141

Case Report

Pancreaticoduodenectomy for an Ampullary Region Carcinoma Occurred in Annular Pancreas Coexistent with Replaced Common Hepatic Artery

Ryuji Komine,¹ Atsushi Shimizu,¹ Kazuhiko Mori,¹ Keisuke Minamimura,¹ Toru Hirata,¹ Takashi Kobayashi,¹ Nobuo Toda,² and Masaya Mori³

¹Department of General and Gastrointestinal Surgery, Mitsui Memorial Hospital, 1 Kanda Izumicho, Chiyoda-Ku, Tokyo 101-8643, Japan
²Department of Gastroenterology, Mitsui Memorial Hospital, 1 Kanda Izumicho, Chiyoda-ku, Tokyo 101-8643, Japan
³Department of Pathology, Mitsui Memorial Hospital, 1 Kanda Izumicho, Chiyoda-ku, Tokyo 101-8643, Japan

Correspondence should be addressed to Ryuji Komine; dora.med.rk@gmail.com

Received 14 December 2017; Accepted 23 January 2018; Published 20 February 2018

Academic Editor: William B. Silverman

Copyright © 2018 Ryuji Komine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Introduction. Annular pancreas is a rare congenital abnormality characterized by a ring of pancreatic tissue surrounding the descending portion of the duodenum. Annular pancreas coexisting with replaced common hepatic artery which is also a rare anatomical variation has not been reported previously. Case Presentation. A 53-year-old man visited our hospital complaining of epigastric pain. Based on radiological examinations, he was diagnosed as having pancreatitis, annular pancreas, and hepatomesenteric trunk. One month later, obstructive jaundice developed. Endoscopic examination revealed ampullary region carcinoma. We performed pancreaticoduodenectomy using the “artery-first” approach. Discussion. Both annular pancreas and common hepatic artery anomaly are rare. High-quality preoperative imaging and awareness of such rare conditions are necessary for operative safety. Although the embryological relationship between these anomalies is uncertain, the present case may suggest some relevance between the two. Conclusion. The “artery-first” approach may be a useful method for pancreaticoduodenectomy in patients who have an anatomical abnormality.

1. Introduction

Annular pancreas (AP) is a rare congenital anomaly in which the second part of the duodenum is surrounded by a ring of pancreatic tissue continuous with the head of the pancreas. The prevalence of AP was reported in 3 of 20,000 autopsies and 3 of 24,519 surgical cases [1, 2]. Although pancreatitis, duodenal obstruction, and so on are known as symptoms of AP, approximately two-thirds of the patients are asymptomatic [3]. AP is also regarded as one of the risk factors of pancreatobiliary malignancy. However, replaced common hepatic artery (CHA) arising from the superior mesenteric artery (SMA) was reportedly seen in 1.13% of 19,013 cases [4]. The hepatomesenteric trunk is also rarely encountered but can be problematic in pancreaticoduodenectomy (PD). Although the relationship between these rare anomalies is uncertain, embryologically, they are both considered to occur during the same week of gestation [5]. We herein describe an extremely rare case in which these anomalies coexisted in a patient with ampullary region carcinoma treated by PD with the “artery-first” approach.

2. Case Presentation

A 53-year-old man presented with epigastric pain visited our hospital. Result of the blood analysis indicated hyperamylasemia. The abdominal computed tomography (CT) scan showed diffuse parenchymal enlargement, and he was diagnosed as having mild pancreatitis according to the modified CT severity index. The CT scan also revealed an anomaly of the CHA arising from the SMA (Figure 1(a)) and annular pancreatic duct. Magnetic resonance cholangiopancreatography (MRCP) confirmed that the annular duct formed a loop in the head of the pancreas (Figure 1(b)). There were no pancreaticobiliary maljunction. Neither the common bile duct nor the main pancreatic duct was dilated. Endoscopic ultrasonography was performed to investigate other causes, but the ampulla of Vater could not be observed due to technical difficulty.

(a)

(b)

(c)

Figure 1: Preoperative image findings. (a) Three-dimensional computed tomography scan of the abdomen reveals the replaced common hepatic artery arising from the superior mesenteric artery. (b) Magnetic resonance cholangiopancreatogram shows the annular duct, but no relevant tumor or dilation of the common bile duct and the pancreatic duct. (c) Esophagogastroduodenoscopy shows an ulcer at the ampulla of Vater, and the biopsy results of the ulcer indicate adenocarcinoma. Cannulation of the papilla region could not be performed because of direct invasion of the tumor.

One month later, result of the follow-up laboratory test demonstrated obstructive jaundice. The CT scan revealed a dilatation of the common bile duct. An ulcerative tumor was found around the duodenal papilla region by upper esophagogastroduodenoscopy (Figure 1(c)). Biopsy results from the ulcer indicated adenocarcinoma. Endoscopic retrograde cholangiography (ERCP) was performed to investigate the biliary or pancreatic duct, but cannulation of the ampulla of Vater could not be performed successfully due to the invasion of the tumor.

Subtotal stomach-preserving pancreaticoduodenectomy with dissection of the regional lymph nodes was performed. Laparotomy showed that the pancreatic parenchymal tissue surrounded the descending part of the duodenum. Neither liver metastasis nor peritoneal dissemination was found. The tumor was located in the head of the pancreas. The SMA was exposed first to identify the origin of the CHA (the “artery-first” approach). The CHA arouse from posteriorly to pancreatic head and traveled posteriorly to the portal vein (PV), and then it ran anteriorly to the PV after it branched off the gastroduodenal artery and anterior superior pancreaticoduodenal artery (Figure 2). The pancreas was transected at the neck directly overlying the PV-SMV-splenic vein confluence.

Figure 2: Intraoperative findings. The common hepatic artery is arising from the superior mesenteric artery and runs posterior to the pancreas.

Cholangiopancreatography of the resected specimen showed that the annular duct was connected to the major papilla (Figures 3(a) and 3(b)). The final pathology revealed poorly differentiated adenocarcinoma (Figure 4) without regional lymph node metastasis (International Union Against Cancer TNM classification, 8th edition: T3N0M0, IIA). The patient’s postoperative course was uneventful, and he was discharged 21 days postoperatively. He is doing well without any evidence of recurrence at the most recent follow-up of 6 months postoperatively.

(a)

(b)

Figure 3: Findings of the resected specimen. (a) Cholangiopancreatogram showing cannulation of the resected specimen and injection of urografin from the stump of the main pancreatic duct with the annular duct encircling the descending part of the duodenum and draining at the major papilla (←). (b) Schematic illustration of the pancreatic duct and replaced common hepatic artery, based on the ventral and dorsal pancreas.

Figure 4: Microscopic findings. Tumor-forming ulcer at the papilla region, propagating with cord-like and alveolar structures. It consisted of poorly differentiated adenocarcinoma with the formation of a partially glandular structure.

3. Discussion

Recently, with modern diagnostic imaging devices, such as CT, MRCP, or ERCP, 1 in 250 examined cases was found to have AP [6, 7]. About 700 cases of AP have been reported in the literatures [8], and a relationship with the increasing incidence of pancreatobiliary malignancy also has been described [8–11]. Among the cases reported in the English literatures, there are eight resected cases of ampullary region carcinoma associated with AP (Table 1) [11–17]. It should be important to raise the suspicion of potential malignancy when symptoms occur in adult patients who have AP and have been asymptomatic.

Table 1: Summary of reported cases of ampullary region carcinoma associated with AP.

Case
Author
Age
Sex
Symptoms
Operation
TNM classification
Size (cm)

1
Transveldt et al. [12]
80
F
Jaundice, WL
PD
ND
ND

2
Benger and Thompson [13]
66
M
Jaundice, WL
PD
T2N0M0
ND

3
Rathnaraj et al. [11]
55
M
Jaundice
PD
ND
2 × 2

4
Shan et al. [14]
40
F
Jaundice, AP
PD
ND
ND

5
Shan et al. [14]
45
M
Jaundice, AP
PPPD
ND
ND

6
Foo et al. [15]
78
F
Jaundice, AP
PD
T1N0M0
1.2 × 3.5

7
Yazawa et al. [16]
59
M
ED
PPPD
TisN0M0
2.5 × 2.0

8
Tewari et al. [17]
42
F
Jaundice, AP
PD
ND
2.0 × 2.0

9
Present case
53
M
Epigastric pain
SSPPD
T2N0M0
3.3 × 3.0

PPPD: pylorus-preserving pancreaticoduodenectomy; SSPPD: subtotal stomach-preserving pancreaticoduodenectomy; WL: weight loss; AP: abdominal pain; ED: epigastric discomfort; ND: not described.

Yogi et al. classified the annular pancreas as six variants of the ductal anatomy. In accordance with this classification, type 2, in which the duct of Wirsung encircles the duodenum but drains at the major papilla, corresponds with our case [18]. ERCP is usually useful to diagnose pancreatic duct; however, in our case, the transpapillary approach or cannulation to the pancreatic duct could not be performed because of direct invasion of the carcinoma. MRCP may be another diagnostic option for AP, but it cannot always identify the minor papilla or thin Santorini duct. A contrast study of the resected specimen was the most informative. In our case, AP did not become a technical problem during the operation because the pancreas was transected at the distal side of the AP. It is also important to clearly identify the dilated main pancreas pancreatic duct to understand the path of the annular duct before the operation for safe resection.

Michels described the hepatic arterial anatomy and variations of 200 cadaveric dissections and identified 10 types of hepatic arterial anatomy [19]. Our case was classified as type IX. Accidental ligation of the hepatic arteries can lead to hepatic dysfunction, ischemia of bilioenteric anastomosis, and may result in a fatal leak. From a technical perspective, the “artery-first” approach was also useful in the case of anomaly. Sanjay et al. described types and advantages of six “artery-first” approaches [20]. We used the posterior approach; that is, we exposed and taped the root of the SMA initially in front of the left renal vein after kocherization. This enabled total control of the arterial anomaly before identification and ligation, which contributed to safe resection and secure lymph node dissection even in an extremely rare condition.

Our case may suggest some embryological relevancies between AP and hepatic arterial anomalies. The developmental mechanism of AP has not been determined, but Lecco’s theory, in which the adherence of the ventral bud to the duodenal wall prior to rotation is regarded as the causes, seems to be more accepted than other theories [21]. The hepatomesenteric trunk is considered to build due to degeneration and adhesion of ventral splanchnic arteries [22]. Both anatomical anomalies are formed during the same fifth to seventh week of gestation. Fukai et al. reported that all of the pancreatic tissue of the AP may be derived from the ventral anlage, and presented a hypothesis about Yogi’s type 2 AP based on Lecco’s theory. According to the theory, incomplete rotation, overgrowth of the tip of the ventral anlage, and adhesion to the dorsal anlage could make the annular duct fused with the main duct of the dorsal anlage instead of crossing over the lower bile duct [23]. In addition, the CHA anomaly was reported to sometimes pass through the pancreatic head and running in front of the main pancreatic duct in those cases [19, 24, 25]. In our case, the CHA passed behind the head of the pancreas, on the left side of the annular duct. It may be rational to consider that the rotation and adhesion of the pancreatic bud occur somewhat later than the formation of the vascular structure, and the vasculature is one of the regulators that determine the position of the fusion of the main pancreatic duct and annular duct.

Abbreviations

AP: | Annular pancreas
CHA: | Common hepatic artery
SMA: | Superior mesenteric artery
PD: | Pancreaticoduodenectomy
CT: | Computed tomography
MRCP: | Magnetic resonance cholangiopancreatography
EGD: | Esophagogastroduodenoscopy
ERCP: | Endoscopic retrograde cholangiography.

Consent

Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Authors’ Contributions

Ryuji Komine and Atsushi Shimizu performed the operation, conceived and designed the study, and drafted the manuscript. Keisuke Minamimura, Kazuhiko Mori, Toru Hirata, and Takashi Kobayashi had taken charge of management of the patients. Nobuo Toda Masaya Mori had contributed significantly to the assessments and supervised other authors. All authors read and approved the final manuscript.

References

M. M. Ravitch and A. C. Woods Jr., “Annular pancreas,” Annals of Surgery, vol. 132, no. 6, pp. 1116–1127, 1950.

T. Theodorides, “Annular pancreas,” Journal of Chiropractic Education, vol. 87, pp. 445–462, 1964.

J. E. Cunha, M. S de Lima, J. Jukemura et al., “Unusual clinical presentation of annular pancreas in the adult,” Pancreatology, vol. 5, no. 1, pp. 81–85, 2005.

E. Panagouli, D. Venieratos, E. Lolis, and P. Skandalakis, “Variations in the anatomy of the celiac trunk: a systematic review and clinical implications,” Annals of Anatomy-Anatomischer Anzeiger, vol. 195, no. 6, pp. 501–511, 2013.

T. W. Sadler, Medical Embryology, Lippincott Williams & Wilkins, Philadelphia, PA, USA, 12th edition, 2012.

B. B. Baggott and W. B. Long, “Annular pancreas as a cause of extrahepatic biliary obstruction,” American Journal of Gastroenterology, vol. 86, no. 2, pp. 224–226, 1991.

G. M. Glazer and A. R. Margulis, “Annular pancreas: etiology and diagnosis using endoscopic retrograde cholangiopancreatography,” Radiology, vol. 133, no. 2, pp. 303–306, 1979.

N. J. Zyromski, J. A. Sandoval, H. A. Pitt et al., “Annular pancreas: dramatic differences between children and adults,” Journal of the American College of Surgeons, vol. 206, no. 5, pp. 1019–1025, 2008.

Y. Yogi, S. Kosai, S. Higashi, T. Iwamura, and T. Setoguchi, “Annular pancreas associated with pancreatolithiasis: a case report,” Hepatogastroenterology, vol. 46, no. 25, pp. 527–531, 1999.

K. Sandrasegaran, A. Patel, E. L. Fogel, N. J. Zyromski, and H. A. Pitt, “Annular pancreas in adults,” American Journal of Roentgenology, vol. 193, no. 2, pp. 455–60, 2009.

S. Rathnaraj, S. K. Singh, and M. Varghese, “Annular pancreas associated with carcinoma of papilla,” Indian Journal of Gastroenterology, vol. 17, p. 110, 1998.

E. Transveldt, R. G. Keith, J. Fonger, and M. M. Fischer, “Annular pancreas associated with coexistent ampullary carcinoma in an elderly woman,” Canadian Journal of Surgery, vol. 25, no. 6, pp. 687-688, 1982.

J. R. Benger and M. H. Thompson, “Annular pancreas and obstructive jaundice,” American Journal of Gastroenterology, vol. 92, no. 4, pp. 713-714, 1997.

Y. S. Shan, E. D. Sy, and P. W. Lin, “Annular pancreas with obstructive jaundice: beware of underlying neoplasm,” Pancreas, vol. 25, no. 3, pp. 314–316, 2002.

F. J. Foo, U. Gill, C. S. Verbeke, J. A. Guthrie, and K. V. Menon, “Ampullary carcinoma associated with an annular pancreas,” Journal of the Pancreas, vol. 8, no. 1, pp. 50–54, 2007.

N. Yazawa, T. Imaizumi, D. Furukawa et al., “An annular pancreas associated with carcinoma of the papilla of Vater: report of a case,” Surgery Today, vol. 42, no. 5, pp. 497–501, 2012.

M. Tewari, A. Verma, and H. Shukla, “Carcinoma of the ampulla of Vater associated with annular pancreas,” Indian Journal of Surgery, vol. 78, no. 5, pp. 409-410, 2016.

Y. Yogi, T. Shibue, and S. Hashimoto, “Annular pancreas detected in adults, diagnosed by endoscopic retrograde cholangiopancreatography: report of four cases,” Gastroenterologia Japonica, vol. 22, no. 1, pp. 92–99, 1987.

N. A. Michels, “Newer anatomy of the liver and its variant blood supply and collateral circulation,” American Journal of Surgery, vol. 112, no. 3, pp. 337–347, 1966.

P. Sanjay, K. Takaori, S. Govil, S. V. Shrikhande, and J. A. Windsor, “‘Artery-first’ approaches to pancreatoduodenectomy,” British Journal of Surgery, vol. 99, no. 8, pp. 1027–1035, 2012.

T. M. Lecco, “Zur morphologic des pankreas annulare,” Sitzungsb Akad Wissensch, vol. 4, pp. 299–304, 1910.

Y. Wang, C. Cheng, L. Wang, R. Li, J. H. Chen, and S. G. Gong, “Anatomical variations in the origins of the celiac axis and the superior mesenteric artery: MDCT angiographic findings and their probable embryological mechanisms,” European Radiology, vol. 24, no. 8, pp. 1777–1784, 2014.

M. Fukai, T. Kamisawa, S. I. Horiguchi et al., “A case of annular pancreas with Wirsung’s duct encircling the duodenum: embryological hypothesis based on cholangiopancreatographic and immunohistochemical findings,” Clinical Journal of Gastroenterology, vol. 10, no. 3, pp. 283–288, 2017.

S. Yamamoto, K. Kubota, K. Rokkaku, T. Nemoto, and A. Sakuma, “Disposal of replaced common hepatic artery coursing within the pancreas during pancreatoduodenectomy: report of a case,” Surgery Today, vol. 35, no. 11, pp. 984–987, 2005.

M. Mizumoto, S. Nishimura, G. Honjo, and S. Matsusue, “Pancreaticoduodenectomy for carcinoma of the ampulla of Vater with common hepatic artery originated from hepatomesenteric trunk, passing through the pancreatic head: report of a case (in Japanese),” Japanese Journal of Gastroenterological Surgery, vol. 42, no. 11, pp. 1670–1675, 2009.