Diabetic Striatopathy: Case Report and Possible New Actors

Diabetic striatopathy is a very rare neurological complication of diabetes. We report the case of an 86-year-old woman with poorly controlled type 2 diabetes admitted to the internal medicine ward for sudden onset of altered sensorium and severe bilateral choreiform and ballistic movements. The precise pathophysiology of this condition is not well understood. Our communication aims to remind clinicians to consider the possibility of diabetic striatopathy when poor-controlled diabetic patients have sudden-onset choreiform and ballistic movements. Moreover, this case suggests the possibility that oxidative and endoplasmic reticulum stress may be involved in this process.


Introduction
Diabetic striatopathy (DS) is a very rare neurological complication of diabetes. Te classic clinical manifestation of DS includes the triad of acute or subacute hemichoreahemiballismus, hyperglycemic state, and unique reversible abnormalities limited to the striatum on neuroimaging [1]. It was frst described in 1960 by Bedwell [2].
Tis case report aims to remind clinicians to consider DS when poor-controlled diabetic patients have sudden-onset choreiform and ballistic movements. Moreover, authors suggest the possibility that oxidative and endoplasmic reticulum stress may be involved in the pathogenesis of DS.

Clinical Presentation.
We report the case of an 86year-old woman with poorly controlled type 2 diabetes admitted to the internal medicine ward for the sudden onset of altered sensorium and severe bilateral choreiform and ballistic movements. She had previously been admitted to the emergency department.
Te patient had a history of hypertension, chronic coronary artery disease, and chronic atrial fbrillation. Te diabetes was home-treated with repaglinide.

Laboratory Results.
Laboratory results showed leukocytosis elevated C-reactive protein, hyperglycemia, and a positive urine test for infection. No faecal occult bloods was not detected nor were there any visible gastroenterological losses but iron, folic acid, and B12 vitamin defciencies were detected (the main laboratory tests at admission and at discharge are depicted in Table 1). Ferritin values were in the normal range, likely due to the current infection.

Imaging and Instrumental Examinations.
A noncontrast brain computed tomography revealed hyperdensity of the right basal nuclei, as depicted in Figure 1.
Afterwards, the patient underwent magnetic resonance that revealed hyperintensity on T1 in both the basal ganglia associated with areas of decreased signal intensity on T2 with pigments deposition (see Figure 2).
An electroencephalogram was also performed: it demonstrated nonspecifc slow waves without spikes.

Terapeutic Approach.
Te patient received fuids, insulin, and symptomatic treatment to control choreiform and ballistic movements (clonazepam). Staphylococcus aureus was detected in the urine. Piperacillin-tazobactam therapy was administered.
Supplements with iron, folic acid, and B12 vitamins were administered due to defciencies.
After two weeks, symptoms improved as well as the glucose control, and then she was discharged.
Oral antidiabetic dosage was improved, without insulin therapy because of sufcient insulin reserves. A close diabetes follow-up was organised. Nevertheless, the patients did not come to the following appointments.

Discussion
Tis case report of diabetic striatopathy (DS) is similar to others described [1,3]. Now the challenge is the understanding of the pathogenic mechanisms of this condition.
Chorea is a hyperkinetic dyskinesia characterized as being involuntary, irregular, unpredictable, and small-amplitude. Ballismus is featured as being large-amplitude, arrhythmic, and more proximal. Chorea-ballismus can appear in the large majority of patients with DS [1].

Case Reports in Neurological Medicine
HIV encephalitis, and prion diseases), and drugs (neuroleptics, lithium, antiepileptic drugs, oral contraceptives, estrogen replacement therapy, steroids, methotrexate, cyclosporine and fuoroquinolones) [1,2]. For our patient, the interaction of multiple mechanisms might explain the case: a hyperglycemic state due to an incipient infection together with vascular insufciency in a poor-controlled diabetic patient.
Te precise pathophysiology of DS is not well understood. Biopsy studies suggest that the lesion is a vasculopathy with gliosis restricted to the striatum. Postmortem fndings have been somewhat inconsistent but include reactive astrocytosis, patchy ischemic necrosis, petechial hemorrhage, vascular proliferation, and arteriolar changes similar to the diabetic proliferative retinopathy.
Our communication aims to remind clinicians to consider the possibility of diabetic striatopathy when poorcontrolled diabetic patients have sudden-onset choreiform and ballistic movements. Moreover, this case suggests the possibility that oxidative and endoplasmic reticulum (ER) stress may be involved in this process. Tis is only speculative because we have not examined the molecules involved in these pathways and no in vitro-tests have been performed.
However, this is the very frst time that these mechanisms have been mentioned as possible mediators in DS.
In fact, these actors (oxidative and ER stress) are very prominent in neurological disorders, in both ischemic and hemorrhagic stroke, and in diabetes itself. Chronic hyperglycemia-associated oxidative stress and low-grade infammation are considered to play critical roles in the progression of diabetic complications [4,5].
After intracerebral hemorrage, both oxidative and ER stress levels are upregulated and alleviating either ER or oxidative stress limits secondary neuronal damage. Using nicotinamide adenine dinucleotide phosphate oxidase inhibitors and nonspecifc reactive oxygen species scavengers, oxidative stress is reduced, cerebral vascular function improves, and cerebral amyloid angiopathy-related microhemorrhages are reduced. Reactive astrogliosis and apoptosis have been shown to be reduced using antioxidant compounds [6].
DS is a very uncommon disease, but its knowledge should be mandatory for physicians, and its mechanisms have to be better investigated. Tis case report adds same knowledge about this rare condition together with previous works [1,3].
To conclude, in the future, the detection of circulating markers of oxidative and ER stress should be given serious consideration in patients with DS, in order to eventually propose antioxidant therapy and compounds ameliorating the ER stress, as is in the case of diabetes [7].
Postmortem studies in the brain tissues of DS patients should be focused on the detection of oxidative and ER stress markers. Te results will strengthen or discard our hypothesis.

Data Availability
Te data used to support the fndings of this study are included within the article.

Conflicts of Interest
Te authors declare that they have no conficts of interest.