Ectopic pregnancy continues to be the most common cause of first trimester maternal death [
The patient is a 32-year-old G5 P1031 whose last menstrual period was approximately 2 weeks prior to presentation. She presented to the emergency room with the complaints of abdominal pain, sporadic dysuria, and difficulty passing stool. She denied vaginal bleeding, chest pain, shortness of breath, or palpitations.
The patient’s obstetric history was significant for two ectopic pregnancies. She underwent an exploratory laparotomy and a right salpingectomy for a right tubal pregnancy in Jamaica, West Indies in 2007. Subsequently, she had a laparoscopic left salpingectomy for a tubal pregnancy at our institution in 2009. The pathology report from 2009 confirmed a left tubal pregnancy.
The patient had informed the emergency staff that she could not be pregnant, as she had both tubes previously removed. Despite this, a urine pregnancy test was ordered as part of the emergency room’s routine lab work, and it was found to be positive. Her serum beta human chorionic gonadotropin (beta-hCG) level was 880 milli-international units/mL. Additional hematologic parameters were within normal limits (WBC count 8.9 hematocrit 32.7) and the comprehensive metabolic panel was unremarkable (sodium 139 potassium 3.7 bicarbonate 104 chloride 22 BUN 9 creatinine 0.93 glucose 95 mg/dL, liver function AST/ALT 16 and 15). Transvaginal sonography was performed (Figures
Sonographic images of the left adnexal region with and without color Doppler: large left adnexal mass (blue arrows), measuring approximately 6.3
The impression was a ruptured ectopic pregnancy and surgical intervention was recommended. The patient consented and laparoscopy was performed. Upon entry into the abdomen, 1000 milliliters of clotted and liquid blood was found. The stumps of both fallopian tubes were present and the right ovary was found to be unremarkable. In the region of the left adnexa, dense adhesions were found. Laparoscopic adhesiolysis revealed diffuse involvement of the large bowel with the incorporation of the left ovary into the mass. Active bleeding was noted from the exposed portion of the ovarian tissue and the decision was made to convert to laparotomy. Further dissection at laparotomy allowed full visualization of the ovary. Two 1 cm defects were identified, one of which was actively bleeding and the other spilling grossly identifiable trophoblastic material surrounding a gestational sac. This tissue was easily removed and submitted to pathology for permanent section. Bleeding points on the ovarian surface and in the area of implantation were controlled with suture ligation. The ovary was otherwise normal and was left in situ. Postoperatively, the patient recovered without any adverse events and was followed with serum beta-hCG levels which declined appropriately. Figure
Ovarian cyst with hemorrhage, decidua, and trophoblastic tissue [
We present a case of an ovarian pregnancy that occurred in a patient with a history of two previous tubal pregnancies, both of which were treated with salpingectomy. As the antecedent tubal pregnancy was diagnosed and treated at our institution, the pathology report and glass slides were available for review. This review confirmed the original diagnosis and provided a clinical and surgical correlation with the intraoperative findings of the absence of tubes and fimbriae. While the Spiegelberg criteria stipulates that the distal tube and fimbria must be identified to confirm the diagnosis of ovarian pregnancy, the surgical absence of the tube further strengthens the pathologic diagnosis of an ovarian ectopic in this case. This is especially relevant as the purpose of the criteria was to exclude ectopics originating in the tube that simply appeared to incorporate ovarian tissue. The absence of the tube rules out the possibility that the final diagnosis is an “overdiagnosis.” The remaining pathologic criteria published by Spiegelberg were satisfied.
The clinical presentation of an ovarian pregnancy is similar to other ectopic pregnancies in general. This patient presented classically. The history of the present illness and the findings on laboratory evaluation and imaging studies were typical of an ectopic pregnancy. The clinical course, including the outcome of the surgery and the postoperative recovery, was unremarkable. What makes this case unique is the history of bilateral salpingectomy.
Using PubMed, we performed a search using the following key words: “ovarian,” “pregnancy,” “recurrent,” and “ectopic” and did not find another case of an ovarian pregnancy in a patient with a history of two previous tubal pregnancies. There was a case of recurrent ectopic pregnancies in the remnant of a tube following salpingectomy [
The incidence of an ovarian ectopic pregnancy and ectopic pregnancy in general has been rising over the past 20 years. A consensus has emerged that attributes this finding to increases in the risk factors for ectopic pregnancy. These factors are climbing rates of ascending pelvic infection, the trend in delaying childbirth into the 4th and 5th decades, and greater availability and application of assisted reproductive technologies. Of note, the patient presented in this case did not have a history of pelvic inflammatory disease, was young, and did not use fertility drugs.
This is a rare case of an ovarian pregnancy in a patient with a history of two previous tubal pregnancies and two previous salpingectomies. This case underscores the importance of maintaining vigilance in the search for ectopic pregnancy in patients presenting with abdominal pain after fertility impairing surgery.
The authors declare that there is no conflict of interests regarding the publication of this paper.