Case Reports in Obstetrics and Gynecology
Volume 2017 (2017), Article ID 4970802, 11 pages
https://doi.org/10.1155/2017/4970802

Case Report

Uterine Fibroid Torsion during Pregnancy: A Case of Laparotomic Myomectomy at 18 Weeks’ Gestation with Systematic Review of the Literature

Annachiara Basso,¹ Mariana Rita Catalano,¹ Giuseppe Loverro,¹ Serena Nocera,¹ Edoardo Di Naro,¹ Matteo Loverro,¹ Mariateresa Natrella,² and Salvatore Andrea Mastrolia¹

¹Department of Obstetrics and Gynecology, Azienda Ospedaliera Universitaria Policlinico di Bari, School of Medicine, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
²School of Nursing, Azienda Ospedaliera Universitaria Policlinico di Bari, School of Medicine, Università degli Studi di Bari “Aldo Moro”, Bari, Italy

Correspondence should be addressed to Salvatore Andrea Mastrolia; mastroliasa@gmail.com

Received 15 January 2017; Revised 17 March 2017; Accepted 20 March 2017; Published 24 April 2017

Academic Editor: Maria Grazia Porpora

Copyright © 2017 Annachiara Basso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20–40% of women, whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment. Uterine myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain. There are many controversies in performing myomectomy during cesarean section because of the risk of hemorrhage. Nevertheless, the majority of indication arises before labor and delivery due to acute symptoms leading to a discussion regarding the need for intervention during pregnancy. Therefore, we present a case of successful multiple laparotomic myomectomy at 17 + 2 weeks of gestational age and a systematic review of the literature in order to clarify the approach to this pathologic condition and its effect on pregnancy outcome.

1. Introduction

Uterine myomas are the most common benign growths affecting female reproductive system, occurring in 20–40% of women [1], whereas the incidence rate in pregnancy is estimated from 0.1 to 3.9%. The lower incidence in pregnancy is due to the association with infertility and low pregnancy rates and implantation rates after in vitro fertilization treatment [2]. Uterine myomas, usually, are asymptomatic during pregnancy. However, occasionally, pedunculated fibroids torsion or other superimposed complications may cause acute abdominal pain. Urinary and gastroenteric symptoms may occur due to the rapid increase in size in reason of hyperestrogenic environment and, consequently, compression and displacement of surrounding organs. Additionally, fibroids predispose to pregnancy complications, including early miscarriage, antepartum bleeding, preterm labor, premature rupture of membranes, fetal malpresentations, labor dystocia, and postpartum hemorrhage.

Conservative management with anti-inflammatory therapy is considered a gold standard, and surgery is generally avoided during pregnancy because of the risks of hysterectomy secondary to severe hemorrhage, pregnancy injury, and pregnancy loss [3]. The main conditions that induce inevitably the surgical procedure are the torsion of pedunculated fibroids or rare cases of necrosis, resultant inflammatory peritoneal reaction, and, finally, if symptoms persist after 72 hours of pharmacological therapy [4–7]. Therefore, the diagnosis needs a particular attention for the appropriate management choice. Surgical removal fibroids in pregnancy can be performed by laparotomy or laparoscopy technique taking into account the volume and location of nodules [1, 8].

Laparoscopy can be considered in selected cases such as small, subserous, pedunculated myomas.

There are many controversies in performing myomectomy during cesarean section because of the risk of hemorrhage [3]. Nevertheless, the majority of indication arises before labor and delivery due to acute symptoms leading to a discussion regarding the need for intervention during pregnancy.

Therefore, we present a case of successful multiple laparotomic myomectomy at 17 + 2 weeks of gestational age and a systematic review of the literature in order to clarify the approach to this pathologic condition and its effect on pregnancy outcome.

2. Case Report

Uterine myomas are usually asymptomatic during pregnancy. However, pedunculated fibroids torsion may occasionally cause acute abdominal pain [1].

Most cases of laparotomic myomectomy described in literature have been performed during a cesarean section due to the risk of managing them surgically at low gestational age [2–4]. We present a case of a successful multiple laparotomic myomectomy during the second trimester of pregnancy.

A 36-year-old, morbidly obese primigravida presented at our emergency room at 17 + 0 weeks of gestational age complaining of abdominal pain. At clinical examination, the uterus appeared to be of higher volume compared to the gestational age, the abdomen was painful but treatable, and the obstetrical examination was normal. The patient was then referred to US Unit of our Department for further evaluation. The sonographic assessment revealed the presence of three subserous uterine myomas located on anterior wall (maximum diameter: 13.2 cm), the right wall (maximum diameter: 12.6 cm), and the left wall (maximum diameter: 11.7 cm) of the uterus, respectively. All myomas were vacuolated inside as for suspected necrosis. The scan also showed other multiple myomas less than 3 cm in size. Vital signs were monitored (blood pressure 140/90 mmHg, maternal heart rate 124 bmp, SO2 94%, apyretic). Amniotic fluid was normal and fetal well-being was preserved. Thus, the patient was admitted to the High-Risk-Pregnancy Unit. When collecting the medical history, the first trimester ultrasound scan, performed at 11 weeks’ gestation, revealed the presence of the same lesions with a size of 10.8 cm, 10.2 cm, and 6.14 cm, respectively.

Laboratory studies demonstrated rising inflammatory markers (C-reactive protein: 354 mg/L; WBC: 16.92 × 10³ μL).

Due to the persistence of the symptoms, despite of two days of analgesic, antispastic, and antibiotic therapy, after multidisciplinary discussion, and a thorough counseling to inform the parents of the surgical and postoperative risks connected with uterine surgery during the gestation, the patient underwent surgery. Laparotomy approach by longitudinal skin incision, considering the volume and the position of the myomas, was performed under general anesthesia. Three huge bulky subserous pedunculated myomas were evidenced, the largest located at the uterine fundus, with a maximum diameter of 15 cm and a torsion of its pedicle (Figure 1). Furthermore, intra-abdominal adhesions were found within peritoneal cavity. Blunt dissection was undertaken to free the omentum and look for the appendix, which was normal. The three large myomas evidenced by ultrasound were removed and sent for pathologic examination. A pelvic drainage was left and removed 24 hours postoperatively. Pathology showed widespread phenomena of necrosis, especially in the myoma with torsion of its pedicle.

Figure 1: Myoma of the uterine fundus with evidence of torsion of its pedicle.

During the following nine days, the patient received antibiotics, low molecular heparin, and progesterone, and fetal heartbeat was checked daily. Considering the improvement in clinical condition, the patient was discharged with an indication to treatment with progesterone and low molecular heparin.

Three weeks later, at 21 weeks’ gestation, the patient was admitted again due to abdominal pain. Obstetrical evaluation revealed cervical effacement and the transvaginal ultrasound scan showed a reduction of cervical length (18 mm), funneling, and sludge. An ultrasound scan was performed showing good fetal variables. Consequently, the therapy with progesterone was increased. The patient had a positive vaginal culture for Staphylococcus haemolyticus, urine culture was negative, and C-reactive protein resulted to be positive. Therefore, antibiotic therapy with macrolides was given, according to antibiogram result. A cervical cerclage was proposed to the patient, but she refused to undergo the procedure.

Hospitalization lasted for seven days; then the woman was discharged due to an improvement of her clinical condition. The patient underwent obstetric evaluation every two weeks until she presented in labor and delivered vaginally at 38 + 1 weeks’ gestation a healthy female newborn of 2940 g, appropriate for gestational age according to national growth curves [9]. Apgar score was 9/10 at 1′ and 5′ respectively.

3. Data Source and Literature Search

To identify potentially eligible studies, we searched PubMed, Scopus, and Cochrane Library (all from inception to 16 March 2017). No language restrictions were initially applied. We used a combination of key words and text words represented by “myomectomy,” “myoma,” and “pregnancy.”

Two reviewers (Annachiara Basso and Mariana Rita Catalano) independently screened the titles and abstracts of records retrieved through database searches. Both reviewers recommended studies for the full-text review. The screen of full-text articles recommended by at least one reviewer was done independently by the same two reviewers and assessed for inclusion in the systematic review. Disagreements between reviewers were resolved by consensus. For all full-text manuscripts, reference lists were analyzed in order to find additional eligible studies.

4. Results

The electronic database search provided a total of 1855 results. After duplicate exclusion, there were 1611 citations left. Of these, 1508 were not relevant to the review based on title and abstract screening. 103 studies were considered for full-text assessment, of which 40 were excluded for the following reasons: we could not translate 31 articles, while nine papers could not be retrieved even after international librarian search.

Overall, 63 [3–6, 10–67] articles were incorporated for further assessment. The study selection process is shown in Figure 2. The main characteristics of the selected studies are included in Table 1.

Table 1: Characteristics of the relevant studies.

Reference
Number of patients
Gestational age at diagnosis 
(weeks)
Gestational age at myomectomy (weeks)
Type of surgery
Fibroid maximum volume (cm)
Mode of delivery
Gestational age at delivery
Neonatal outcome
(Apgar, birthweight, pH)

De Carolis et al., 2001
18
nd
13
LPT
8
CS
39
8/8, 3150 g

nd
23
LPT
40
CS
38
8/8, 2670 g

nd
19
LPT
14
VD
36
8/9, 3080 g

nd
17
LPT
21
CS
38
8/9, 3060 g

nd
19
LPT
15
Fetal demise at 19 weeks

nd
20
LPT
6
VD
41
9/9, 2970 g

nd
19
LPT
12
CS
39
7/9, 3180 g

nd
8
LPT
9
CS
40
9/9, 3300 g

nd
12
LPT
8
CS
38
9/10, 2780 g

nd
17
LPT
24
CS
38
9/9, 3900 g

nd
15
LPT
10
CS
40
8/10, 3170 g

nd
17
LPT
13
CS
39
9/10, 3100 g

nd
6
LPT
15
nd
nd
nd

nd
20
LPT
8
CS
39
9/10, 2860 g

nd
10
LPT
16
CS
40
9/10, 3500 g

nd
16
LPT
10
CS
39
9/10, 3930 g

nd
13
LPT
14
CS
39
9/9, 3180 g

nd
7
LPT
15
CS
38
9/10 - 2550 g

Domenici et al., 2014
1
16
16
LPT
20
CS
38
8/9 - 3250 g

Michalas et al., 1995
1
14
15
LPT
20
CS
39
2800 g

Danzer et al., 2001
1
12
12
LPT
10
CS
37
9/10, 3235 g;

9/10, 2810 g

Lozza et al., 2011
1
12
16
LPT
18
CS
36
9/9, 2280 g

Joó et al., 2001
1
8
25
LPT
12
CS
40
3600 g

Çelik et al., 2002
5
nd
22
LPT
13
CS
38.6 +/− 1.1
10, 3200 g

nd
18
LPT
10
CS
38.6 +/− 1.1
9, 3400 g

nd
20
LPT
12
CS
38.6 +/− 1.1
10, 3600 g

nd
16
LPT
15
CS
38.6 +/− 1.1
8, 3100 g

nd
13
LPT
20
CS
38.6 +/− 1.1
9, 2800 g

Hasbargen et al., 2002
1
18
18
LPT
15
CS
36
8/9, 2495 g

Umezurike and Feyi-Waboso, 2005
1
19
19
LPT
32
VD
38
8/10, 3500 g

Usifo et al., 2007
1
13
13
LPT
17
CS
38
3990 g

Suwandinata et al., 2009
1
nd
18
LPT
nd
CS
37
8/9, 2950 g

Bhatla et al., 2009
1
8
19
LPT
28
VD
38
2740 g

Leite et al., 2009
1
1st trimester
17
LPT
10
CS
39
9/10, 3315 g

Isabu et al., 2010
1
14
14
LPT
nd
CS
37
2700 g

Leach et al., 2011
1
11
11
LPT
14
CS
40
9/9, 4356 g

Doerga-Bachasingh et al., 2012
1
9
10
LPT
15
CS
37
nd

Jhalta et al., 2016
1
13
13
LPT
16
VD
39
8/10, 3000 g

Kosmidis et al., 2015
1
10
10
LPS
8
nd
nd
nd

Saccardi et al., 2015
1
9
15
LPS
24
CS
41
4460 g, 7.2

Obara et al., 2014
1
6
13
VAG
6
VD
40
2775 g

Currie et al., 2013
1
11
11
LPS
8
nd
nd
nd

Kobayashi et al., 2013
1
21
21
LPT
8
CS
37
2730 g

MacCiò et al., 2012
3
8
19
LPS
11
CS
39
3150 g

20
20
LPS
10
VD
40
3310 g

20
20
LPS
nd
CS
39
3050 g

Shafiee et al., 2012
1
15
21
LPS
15
CS
38
nd

Ardovino et al., 2011
1
14
14
LPS
6
VD
40
3216 g

Müller Vranjes et al.
1
14
18
LPT
35
CS
33
10/10, 1750 g, 7.28

Son et al., 2011
1
18
18
LPS
9
VD
39
3740 g

Kasum 2010
1
15
15
LPT
9
VD
38
nd

Fanfani et al., 2010
1
25
25
LPS
9
VD
40
2950 g

Adeyemi et al., 2007
1
19
19
LPT
30
VD
39
7/10, 3500 g

Okonkwo and Udigwe, 2007
1
19
24
LPT
nd
CS
nd
nd

Dracea and Codreanu, 2006
1
12
13
LPT
24
VD
nd
nd

Melgrati et al., 2005
1
24
24
LPS
7
VD
39
9/9

Sentilhes et al., 2003
1
17
17
LPS
5
CS
37
3530 g

Lolis et al., 2003
13
nd
16
LPT
nd
CS
37
3340 g

nd
15
LPT
nd
CS
39
3600 g

nd
19
LPT
nd
CS
37
2970 g

nd
16
LPT
nd
CS
36
3000 g

nd
15
LPT
nd
Fetal demise at 15 weeks

nd
15
LPT
nd
CS
37
2740 g

nd
16
LPT
nd
CS
38
3180 g

nd
16
LPT
nd
CS
39
3515 g

nd
16
LPT
nd
CS
39
3190 g

nd
19
LPT
nd
CS
38
2920 g

nd
17
LPT
nd
CS
38
3520 g

nd
16
LPT
nd
CS
38
3000 g

nd
15
LPT
nd
CS
29
1606 g

Donnez et al., 2002
1
Before pregnancy
25
LPT
22
CS
35
2280 g

Williamson, 1908
1
22
22
LPT
32
VD
23
Neonatal death

Stewart, 1906
1
20
20
LPT
24
VD
40
nd

Wittich et al., 2000
1
12
15
LPT
20
CS
37
9/9, 3275 g

Majid et al., 1997
1
17
18
LPT
24
Fetal demise 19 weeks

Algara et al., 2015
1
18
18
LPS
7
VD
24
nd

Lockyer, 1914
1
21
21
LPT
nd
VD
40
2300 g

von Hoffmann, 1911
3
16
16
LPT
nd
VD
40
3630 g

22
25
LPT
nd
Fetal demise at 25 weeks

14
15
LPT
nd
VD
40
nd

Andrews, 1910
1
Before pregnancy
9
LPT
nd
VD
40
nd

Swayne, 1908
2
20
20
LPT
nd
nd
nd
nd

16
16
LPT
nd
VD
24
nd

Doran, 1906
1
20
21
LPT
10
VD
40
nd

Evans, 1899
1
20
20
LPT
7
nd
nd
nd

Exacoustòs and Rosati, 1993
13
nd
<26
nd
nd
N.G
40 (8), preterm > 32 (5)
nd

Burton et al., 1989
8
nd
13
LPT
18
VD
40
nd

nd
15
LPT
14
Fetal demise 15 weeks

nd
nd
LPT
5
VD
40
nd

nd
nd
LPT
5
VD
40
nd

nd
nd
LPT
5
VD
40
nd

nd
nd
LPT
5
VD
40
nd

nd
nd
LPT
5
VD
40
nd

nd
nd
LPT
5
nd
nd
nd

Rella et al., 1980
1
10
12
LPT
nd
VD
27
Neonatal death

Pelosi et al., 1995
1
13
15
LPS
6
CS
39
nd

Pelissier-Komorek et al., 2012
1
10
13
LPT
22
VD
35
2280 g

Mollica et al., 1996
18
8–17
10–19
LPT
>10
CS (17), VD (1)
nd
>7 (18), >2500 g (17), <2500 g (1)

Febo et al., 1997
3
nd
12–19
LPT
N.G.
CS (2), abortion (1)
37-38
nd

Bonito et al., 2007
5
nd
9–15
LPT
3.5–14.5
CS (2), VD (3)
38.2
9 +/− 0.83, 3200–4072 g

Vázquez Camacho et al., 2009
1
7
16
LPT
6.2
VD
40
9/9

Makar et al., 1989
1
12
17
LPT
13,500 g
CS
38
9/9, 3950 g

Horno Liria, 1962
1
16
16
LPT
nd
VD
40
3600 g

Alanis et al., 2008
1
7
12
LPT
30
VD
38
2330 g

Ardizzone, 1955
27
8
8
LPT
nd
nd
nd
nd

8
8
LPT
nd
nd
nd
nd

8
8
LPT
nd
Miscarriage at 9 weeks

24
24
LPT
nd
Fetal demise at 25 weeks

8
8
LPT
nd
Miscarriage at 8 weeks

16
16
LPT
nd
nd
nd
nd

8
8
LPT
nd
nd
nd
nd

8
8
LPT
nd
nd
nd
nd

12
12
LPT
nd
Fetal demise at 14 weeks

20
20
LPT
nd
nd
nd
nd

16
16
LPT
nd
nd
nd
nd

20
20
LPT
nd
nd
nd
nd

20
20
LPT
nd
nd
nd
nd

12
12
LPT
nd
nd
nd
nd

12
12
LPT
nd
Fetal demise at 13 weeks

8
8
LPT
nd
nd
nd
nd

8
8
LPT
nd
nd
nd
nd

12
12
LPT
nd
Fetal demise at 13 weeks

12
12
LPT
nd
nd
nd
nd

16
16
LPT
nd
Fetal demise at 17 weeks

8
8
LPT
nd
nd
nd
nd

12
12
LPT
nd
nd
nd
nd

12
12
LPT
nd
nd
nd
nd

12
12
LPT
nd
nd
nd
nd

8
8
LPT
nd
nd
nd
nd

12
12
LPT
nd
Fetal demise at 12 weeks

12
12
LPT
nd
nd
nd
nd

Cozzi, 1967
16
nd
12
LPT
nd
VD
40
nd

nd
12
LPT
nd
VD
40
nd

nd
8
LPT
nd
VD
40
nd

nd
8
LPT
nd
VD
40
nd

nd
16
LPT
nd
VD
38
nd

nd
8
LPT
nd
VD
40
nd

nd
12
LPT
nd
VD
38
nd

nd
8
LPT
nd
VD
40
nd

nd
16
LPT
nd
VD
40
nd

nd
20
LPT
nd
VD
36
nd

nd
8
LPT
nd
VD
40
nd

nd
12
LPT
nd
VD
40
nd

nd
12
LPT
nd
VD
40
nd

nd
12
LPT
nd
VD
40
nd

nd
16
LPT
nd
VD
40
nd

nd
8
LPT
nd
VD
40
nd

Rochet et al., 1964
14
nd
nd
LPT
10
nd
nd
nd

Sciannameo et al., 1996
1
20
20
LPT
4
nd
nd
nd

nd, not determined; CS, cesarean section; VD, vaginal delivery; LPT, laparotomy; LPS, laparoscopy; VAG, vaginal surgery.

Figure 2: Study selection process.

5. Discussion

Our review included 197 women undergoing myomectomy during pregnancy. The procedure was successful in 184 women, while in the remaining 13 cases a miscarriage or fetal demise happened after the myomectomy.

In 14 cases, a laparoscopic approach was chosen; in one case there was a vaginal surgery, while all the other cases for which the surgical information was available underwent laparotomy. These data confirm that the most used surgical intervention for myomas during pregnancy is the laparotomy route.

Maternal outcomes were favorable after myomectomy, with only two episodes of hemoperitoneum [33, 67], one uterine abscess [39], and only one woman requiring perioperative blood transfusion [61].

Moreover, the analysis of all reports was limited by two factors: (1) the heterogeneity of diagnostic information as well as descriptive data connected to operation and pathology examination which did not allow clear categorization of the pathology preoperatively and postoperatively and (2) the large amount of missing or unreported data.

6. Conclusion

Myomectomy is a feasible procedure if performed during pregnancy. Candidates need to be chosen carefully among those with symptomatic myomas, since abdominal surgery during pregnancy can be associated with an increased risk for the development of the great obstetrical syndromes, especially preterm labor and delivery.

Disclosure

This paper has been presented in part at the 19th National Congress of the Italian Society of Perinatal Medicine (Società Italiana di Medicina Perinatale, SIMP), Naples (Italy), 19–21 January 2017.

Conflicts of Interest

The authors declare that there are no conflicts of interest.

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