GCT is a rare neoplasm and usually shows the benign character. GCT can occur in any body site and may be multifocal. The most common involved site is tongue which accounts for nearly 30% of all cases but skin and subcutaneous tissue are also affected frequently. Breast is an unusually involved site and accounts for 6% of all GCTs. The histiogenesis of GCT is still controversial but further investigations and immunohistochemical examinations were exposed to neural origin and the tumor is thought to be derived from Schwann cells of peripheral nerves. Generally used technique to diagnose GCT is the positivity of S-100 immunohistochemical staining. Despite its benign nature, GCT may mimic breast carsinoma clinically and radiologically and easily be misdiagnosed for breast cancer. We herein report a case of granular cell tumor that arose in a 56 year-old female patient who previously had been treated from an invasive ductal carcinoma in contralateral breast.
Granular cell tumor (GCT) was first described by Abrikossoff in 1926 [
We herein report a case of granular cell tumor that arose in a patient who previously had been treated from an invasive ductal carcinoma in contralateral breast.
A 56-year-old female presented with a mass in her left breast that detected on a routine mammogram. She had been invasive ductal carsinoma in her right breast 3 years ago and modified radical mastectomy has been performed subsequently. In a routine follow-up mammography breast ultrasound imaging showed a mass in the upper outer quadrant and near to axillary tail of her left breast which measured
A mammography image with
An MRI image demonstrates an axillary reticular mass lesion with T1A hypointense signal intensity changes.
Pathological microscopic examination demonstrates the infiltration of cells with eosinophilic granular cytoplasm (a); (hematoxylin eosin,
When Abrikossoff initially described granular cell tumor, it was decelerated that the tumor had myogenic origin and name of granular cell myoblastoma due to their cytological similarities to myogenic cells [
GCT can occur in any body site and may be multifocal. The most common involved site is tongue which accounts for nearly 30% of all cases but skin and subcutaneous tissue are also affected frequently. Breast is an unusuall involved site and accounts for 6% of all GCTs [
Breast carcinomas are frequently localized in the upper outer quadrant. In contrast, GCTs of breast commonly occur in the upper inner quadrant of the breast and that appears to parallel the distribution area of the supraclavicular nerve [
Clinical presentations of breast GCT are 70% of cases detected by palpation, 26% through screening, and 4% during followup after breast malignancy. The mass features are various and described as firm and painless or as elastic consistency with breast pain. Generally the masses are mobile but may be fixed to the pectoralis muscle [
Colocalization and coexistence with IDC has been reported in previous publishings [