Chondrosarcoma is a malignant tumor originating in cartilaginous cells. And there are only few reports of the case of chondrosarcoma in temporomandibular joint. We discuss a case of chondrosarcoma in temporomandibular joint in a 28-year-old man. Tumor was in contact with the dura, but en bloc resection was performed. After surgical resection of the tumor, face defect was reconstructed by rectus abdominis-free flap. And there is no recurrence after ten years from the resection.
Chondrosarcoma is a malignant tumor originating in cartilaginous cells and retaining this nature throughout its evolution. Next to osteogenic sarcoma, chondrosarcoma is the most common bone tumor [
It is rare in the head and neck area especially in the mandible. And there are only few cases of chondrosarcoma in temporomandibular joint. Despite the malignant tumor, chondrosarcoma cases have a long duration from onset to first visit to the hospital [
And treatment of the tumor in the temporomandibular joint is very difficult, because of involvement of facial nerve, parotid gland, and cranial base.
This report describes the details of the case with diagnosis and treatment.
A 28-year-old man noticed a swelling of the left preauricular region ten years before presenting at our hospital and simultaneously had a mouth opening limitation.
Although a mouth opening limitation was decreased gradually, he noticed a spontaneous pain of the same region one year before presenting. He visited our clinic, and the patient denied any history of general systemic diseases. The size of preauricular swelling was 40 mm in diameter, but there was no facial paralysis. The lesion was elastic, hard, and tender and was covered with normal skin. There were no abnormal findings about cervical lymph nodes (Figure
Left side preauricular swelling on presentation.
The mouth opening was 23 mm between upper and lower incisors, and there was a restriction of both lateral and anterior movements.
Panoramic X-ray showed a bone resorption from left fossa to condyle (Figure
Bone resorption from left fossa to condyle in panorama radiograph.
Computed tomography (CT) scan showed a mass arising from the temporomandibular joint and size was 40 mm in length, 50 mm in width, and 30 mm in height. Enhancement of tumor was low (Figure
(a) Low-enhanced tumor around the condyle head in contrast-enhanced CT scan; (b) infratemporal fossa erosion and middle cranial invasion of tumor in coronal view of CT scan; (c) tumor expansion close to dura in enhanced MRI.
Magnetic resonance imaging (MRI) showed that tumor was expanding close to dura (Figure
To make differential diagnosis, the biopsy was done with preauricular incision. Under the zygomatic arch, the tumor was exposed by collagen capsule incision. The tumor seemed gelatinous. In histological findings, heterogeneous sized tumor cells were embedded in chondrocyte lacuna in the mucinous or chondroid stroma. Although the mitotic figures were not seen, polymorphism of the tumor cells was significant. The diagnosis was chondrosarcoma.
The mass was wide excised and removed from the adjacent structure (temporal process of zygoma, zygomatic process of temporal bone, ramus, and parotid gland) and removed in a single block.
The base of the cranial bone had two bone defects in 5 mm size, but there was no invasion of dura, and the resection of dura was not performed.
In the resected specimen, the disk and lower synovial membrane was seen in intact, and the tumor invaded left parotid gland.
Microscopic examination showed that the tumor was composed of a diffuse proliferation of atypical chondrocytic cells in myxoid or chondroid matrix where granular calcified materials were scattered (Figure
(a) Atypical chondrocytic cells in myxoid or chondroid matrix showing scattered granular calcified materials (×40, HE staining) and (b) pleomorphism with bizarre appearance of nuclei (×400, HE staining).
For the left buccal defect, reconstruction of the left buccal area was done with abdominus cutaneous flap one year after tumor resection (Figure
(a) Frontal view of the patient after tumor resection, (b) lateral view of the patient after tumor resection, and (c) intraoperative view of reconstructive surgery.
The recurrence was not seen after ten years from the tumor resection (Figure
Frontal view of the patient one year after reconstructive surgery.
Chondrosarcoma is a malignant tumor originating in cartilaginous cells and retaining this nature throughout its evolution. Excluding the report with some missing clinical data, there are only seventeen reports of the cases of chondrosarcoma in temporomandibular joint [
About the age, the mean age of the temporomandibular joint (TMJ) chondrosarcoma is 48 years, and Murayama et al. [
And about sex distribution, although Murayama et al. [
All these characters of chondrosarcoma in temporomandibular joint are different from chondrosarcoma of head and neck area.
The most major symptom is swelling, followed by pain. Trismus was found in half of the cases. In cases presenting with a preauricular mass, intra-articular tumor can be misdiagnosed as other benign or malignant diseases, such as osteochondromatosis, osteoarthritis, rheumatoid arthritis, avascular necrosis, and condylar fractures. And chondrosarcoma is sometimes misrecognized with temporomandibular disorder. This could be one of the reasons for diagnostic delay.
And some cases had no complaint of pain like our case, and those cases had tendency to have long symptom duration.
And the average of symptom duration of TMJ group is 24 months. It was longer than 8 months in mandible tumor by Murayama et al. [
To make a correct diagnosis panorama X-ray, CT, and MRI are effective.
Panorama X-ray showed the apparent resorption of condyle head. These findings suggested the tumor in the condyle but not adequate extension area. CT scan showed the invasion of middle cranial fossa and MRI showed tumor expansion close to dura. Performing both CT scan and MRI leads to accurate diagnosis and to making adequate treatment plan.
Cranial invasion was reported by Morris et al. [
From Garzino-Demo et al.’s review [
Summary of data obtained from the TMJ chondrosarcoma cases reported in the literature and our case.
Gender | Age | Duration | Symptoms | Appearance at presentation | Treatment | Follow-up | |||||
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(years) | (months) | Swelling | Pain | Occlusion | Trismus | Other | (months) | ||||
Gingrass |
F | 46 | 12 | + | + | + | Slight TMJ space, widening, and subcortical sclerosis | S | — | ||
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Lanier et al. |
F | 48 | 24 | + | + | + | Condyle resorption | S | — | ||
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Richter et al. |
F | 75 | 10 | + | + | − | Hearing loss | TMJ space widening, erosion of glenoid fossa, and increased length of condylar neck | S | 12 | |
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Tullio and D’Errico |
F | 17 | 8 | + | − | Condyle resorption | S | — | |||
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Nortjé et al. |
M | 40 | 6 | + | + | + | TMJ space widening, condyle elongated and distorted | S | 24 | ||
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Cadenat et al. |
F | 60 | 0 | + | + | — | S | 6 | |||
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Morris et al. |
F | 29 | 24 | + | − | − | Headache | Mass from condyle to infratemporal fossa, cranial fossa eroded | S + RT | 6 | |
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Wasenko and Rosenbloom |
F | 49 | 0 | + | + | − | Hearing loss | Mass from condyle to infratemporal fossa with calcification | S | — | |
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Nitzan et al. |
F | 36 | 72 | + | + | + | TMJ space radiolucent lesion, resorption of condyle | S | 84 | ||
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Sesenna et al. |
F | 60 | 12 | + | − | + | Mass from condyle to infratemporal fossa with calcification | S | 60 | ||
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Batra et al. |
M | 65 | 18 | + | − | − | Hearing loss | Mass anterior to ear canal encasing the mandibular condyle | S | 7 | |
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Mostafapour and Futran |
F | 31 | 96 | + | − | Left pterygoid mass with involvement of TMJ | S | — | |||
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Mostafapour and Futran |
F | 52 | 18 | + | − | Mass on right TMJ, involvement of petrous temporal bone and middle fossa | S + RT | 6 | |||
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Yun et al. (2008) [ |
F | 29 | 120 | − | − | Laterodeviation | + | Mass centered on TMJ with dondylar resorption | S + RT | — | |
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Gallego et al. |
M | 54 | 3 | + | + | + | Mass from condyle to infratemporal fossa | S | 16 | ||
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Garzino-Demo et al. |
F | 65 | 3 | + | + | Mass centered on TMJ with condylar resorption and calcification | S + RT | 9 | |||
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González-Pérez et al. |
M | 57 | 12 | + | + | Open bite, cross bite | − | Erosion of condyle wihtbone destruction | S | 24 | |
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Our case (2014) | M | 28 |
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+ | − | + | Resorption of condyle and cranial fossa eroded | S | 120 |
S: surgery; RT: radiotherapy; TMJ: temporomandibular joint.
From this point, destructive potential of chondrosarcoma is almost the same, but the duration could influence the extent of bone resorption.
In terms of diagnosis, fine needle biopsy is not enough for chondrosarcoma from collected literature [
We could not conclude the reason of good prognosis of the chondrosarcoma in TMJ comparing with chondrosarcoma in other head and neck areas, but it might be related to the high rate of Grade I in TMJ chondrosarcoma.
About the treatment, all cases had surgery. As Weiss Jr. and Bennett [
Next to the successful tumor resection, esthetic appearance is very important in head and neck area. Nortjé et al. [
In our case, because of large defect of cranial base, mandible, and soft tissue, we used rectus abdominis-free flap. This flap has a low donor morbidity. This flap served good esthetic outcome in this case.
Chondrosarcoma in temporomandibular joint is very rare. Tumor was in contact with the dura, but en bloc resection was performed. Face defect was reconstructed by rectus abdominis-free flap. Open biopsy is definite to get final diagnosis. To make differential diagnosis, panorama X-ray, CT, and MRI are effective.
The authors declare that there is no conflict of interests regarding the publication of this paper.