Case Reports in Surgery
Volume 2020 (2020), Article ID 7942062, 9 pages
https://doi.org/10.1155/2020/7942062

Case Report

Schwannoma of the Base of the Tongue: A Case Report of a Rare Disease and Review of Literatures

Mohd. Yusuf Haider,¹ Manjur Rahim,¹ N. M. K. Bashar,² Md. Zakir Hossain,³ and Sk Md Jaynul Islam⁴

¹Department of ENT, Colonel Malek Medical College, Manikganj, Bangladesh
²Department of ENT, 250 Bed District Hospital, Manikganj, Bangladesh
³Department of Anesthesiology, Colonel Malek Medical College, Manikganj, Bangladesh
⁴Armed Forces Institute of Pathology, Dhaka, Bangladesh

Correspondence should be addressed to Mohd. Yusuf Haider; myhaider05@gmail.com

Received 2 January 2020; Accepted 30 November 2020; Published 31 December 2020

Academic Editor: Christophoros Foroulis

Copyright © 2020 Mohd. Yusuf Haider et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Background. Schwannoma is a benign nerve sheath tumor. It was first identified by Virchow in 1908. These tumors can emerge from any nerve covered with a Schwann cell sheath, including the cranial nerves (with the exception of the optic and olfactory nerves), the spinal nerves, and the autonomous nervous system (Harada H, Omura K and Maeda A, 2001). Case Presentation. A 28-year-old male farmer presented with a swelling at the right side of the base of tongue extending into the oral tongue. It was identified incidentally by his newly married wife while he was yawning. It was asymptomatic. The patient had no difficulty in chewing, swallowing, or phonation and also no sensory or taste abnormalities. The tongue movements were normal. Conclusions. Diagnosis of schwannoma should be considered for a smooth, painless, firm swelling in the tongue. A schwannoma of the tongue may grow large enough before producing any symptom. Around 25–40% of schwannoma happen within the head and neck region, and among these, 1-12% occurs in the oral cavity, most regularly the tongue or mouth floor. Schwannoma of the tongue does not show any age or sex predisposition. It usually presents as a painless lump in the tongue, but when it grows larger than 3.0 cm, it may produce dysphagia, pain, or discomfort and change in the quality of voice. Here, we report a case of large () asymptomatic schwannoma of the tongue in a 28-year-old male patient and review the literature available during the last 61 years.

1. Introduction

Schwannoma is a benign nerve sheath tumor. It was first identified by Virchow in 1908. These tumors can emerge from any nerve covered with a Schwann cell sheath, including the cranial nerves (with the exception of the optic and olfactory nerves), the spinal nerves, and the autonomous nervous system [1]. When the nerve of origin is small, it can be difficult to demonstrate its connection with a given tumor. On the other hand, if the site of origin is a larger nerve, it is observed that the nerve fibers are splayed over the outer side of the capsule instead of being absorbed into the tumor mass [2]. About 25–45% of all schwannomas occur in the head and neck [3]. Around 1–12% of these occur intraorally [4, 5] with the tongue being the most common site [5, 6]. Although there are many case reports of tongue schwannomas in the literature, after Hatziotis et al. [6], there has been no comprehensive review of the literature. We present a case of tongue schwannoma and study the literature available from the last 61 years (1959–2019).

2. Materials and Methods

A PubMed search for the terms “tongue schwannoma,” “lingual schwannoma,” “tongue neurilemmoma,” and “lingual neurilemmoma” was conducted with the 1959–2019 date range. The search was restricted to English case reports. Unless the ventral tongue was also involved, mouth floor schwannomas were not included. All the case reports had confirmed the masses’ identity as schwannomas histologically. From the case reports for data analysis, the following elements were extracted: age, gender, location of schwannoma (anterior one-third vs. posterior two-thirds of tongue), symptoms, tumor size, and treatment modality.

3. Case Report

A 28-year-old male farmer presented with a swelling at the right side of the base of tongue extending into the oral tongue. It was identified incidentally by his newly married wife while he was yawning. It was asymptomatic. The patient had no difficulty in chewing, swallowing, or phonation and also no sensory or taste abnormalities. The tongue movements were normal.

On examination, there was an oval swelling at the right side of base of the tongue measuring about (Figure 1). The surface was smooth, margin regular, and no discoloration or distortion of tongue epithelium. It was nontender, farm in consistency, and was not fixed with underlying or overlying structures. The remaining oral cavity examination was normal; nasopharyngolaryngoscopy revealed no abnormality in the adjacent areas. There was no cervical lymph node enlargement. Clinically, it appeared like a dermoid cyst or lipoma. MRI of the tongue manifested hyperintense well-circumscribed soft tissue mass in the right half of the base of the tongue on T1/T2-weighted image (Figure 2). It was evaluated with FNAC which revealed benign mesenchymal spindle cell neoplasm, suggestive of nerve sheath tumor with possibility of schwannoma (Figure 3). The patient underwent transoral total excision of the mass under general anesthesia with nasotracheal intubation. For the proper visualization of the base of tongue, frenulum of tongue was incised; tongue was released from floor of mouth and pulled out. An incision was given in right lateral margin over the swelling. After splitting the mucosa, mass is exposed, mobilized by blunt dissection, and excised totally (Figures 4–6). Haemostasis was ensured, and wound closed in layers. Histopathological report revealed features of schwannoma (Figure 7). For confirmation of the tissue of origin, immunocytochemistry was done and found strongly positive for S100 protein. There was no symptom or sign of recurrence in 12 months postoperative follow-up (Figure 8).

Figure 1: Large asymptomatic swelling at posterolateral aspect of right side of tongue.

Figure 2: Axial T1 and T2 and sagittal T1-weighted magnetic resonance image showing a well-defined mass centered right to the midline in the base of the tongue. The tumor has a smooth well-defined border, with no invasion.

Figure 3: FNAC: fragment-of-spindle-cells.

Figure 4: Tumor is being removed from the base of the tongue.

Figure 5: Surgical field after removal of the tumour.

Figure 6: Excised tumour from the base of the tongue.

Figure 7: Histopathological examination. The lesion is composed of spindled cells with hypercellular Antoni A areas and hypocellular Antoni B areas.

Figure 8: The patient followed up after 1 (one) year, and there was no recurrence of the disease.

4. Discussion

Though this is not clear of the etiology of the schwannoma, it is known to be derived from nerve sheath Schwann cells, which surround cranial, peripheral, and autonomic nerves [6, 7]. The head and neck are rather common location of this neoplasm. Intraoral schwannoma mainly arise from the ongue, followed by the palate, mouth floor, buccal mucosa, gingiva, lip, and vestibule [8, 9], though the tongue is most commonly involved [10]. The lesion is slow growing, and thus, its onset is usually long before presentation. Lingual schwannoma shows no age or gender predisposition [11]. Usually, it presents as a painless lump in any part of the tongue. The average size at presentation was 2.4 cm. However, when the mass exceeds 3.0 cm, dysphagia, pain (or discomfort), dysphonia, and voice changes are usually present (Table 1).

Table 1: Patients and tumor characteristics of tongue schwannomas.

Author
Year
Gender
Age
Size (cm)
Site
Presentation
Surgical approach

Mercantini and Mopper [13]
1959
M
22
1
Anterior
Intermittent pain
Transoral

Cameron [14]
1959
M
25
1.5
Anterior
Lump
Transoral

Chadwick [15]
1964
F
20
2.2
Posterior
Lump
Transoral

Craig [16]
1964
F
8
3
Posterior
Lump
Transoral

Pantazopoulos [17]
1965
F
45
4.5
Posterior
Dysphasia/change in voice
Transoral

Chamber [18]
1965
M
29
5
Posterior
Throat discomfort
Transoral

Fifer et al. [19]
1966
F
28
3
Anterior
Lump
Transoral

Hatziotis and Aspride [20]
1967
M
25
Hazelnut
Posterior
Lump
Transoral

Oles and Werthemier [21]
1967
M
52
1
Anterior
Lump
Transoral

Paliwal et al. [22]
1967
M
32
2.5
Anterior
Lump
Transoral

Crawford et al. [23]
1968
M
23
0.5
Anterior
Lump
Transoral

1968
M
24
1
Anterior
Lump
Transoral

Das Gupta et al. [24]
1969
F
21
5
Posterior
Pain
Transoral

Bitici [25]
1969
M
40
2.5
Anterior
Slight discomfort
Transoral

Sinha and Samuel [26]
1971
M
23
1.5
Posterior
Dysphagia
Transoral

Mosadomi [27]
1975
M
19
3
Anterior
Painful mass
Transoral

Swangsilpa et al. [28]
1976
M
26
3
Anterior
Lump
Transoral

Sharan and Akhtar [29]
1978
F
30
1.5
Anterior
Change in voice
Transoral

Akimoto et al. [30]
1987
M
15
1
Anterior
Lump
Transoral

Sira et al. [31]
1988
F
18
3
Posterior
Lump
Transoral

Flickinger et al. [32]
1989
F
28
3
Anterior
Lump
Transoral

Talmi et al. [33]
1991
F
75
1
Posterior
Lump
Transoral

Gallesio and Berrone [34]
1992
F
21
1.9
Anterior/base
Dysphonia/paresthesia/chewing difficulty
Transoral

Lopez and Ballistin [10]
1993
M
24
0.6
Anterior
Lump
Transoral

Haring [35]
1994
F
49
2
Anterior
Lump
Transoral

Nakayama et al. [36]
1996
F
40
5.5
Anterior
Lump
Transoral

Dreher et al. [37]
1997
F
31
3
Base
Dysphagia
Transoral

Spandow et al. [38]
1999
M
37
7.9
Posterior
Throat discomfort
Transoral

de Bree et al. [2]
2000
F
24
5
Posterolateral/base
Lump
Submandibular

Pfeifle et al. [39]
2001
F
30
0.3
Anterior
Lump
Transoral

Cinar et al. [40]
2004
M
7
1
Anterior
Lump
Transoral

Bassichis and McMlay [41]
2004
M
9
2.3
Posterior/base
Snoring
Transoral

Nakasato et al. [42]
2005
F
9
2
Posterolateral/base
Bleeding/ulceration
Transoral

Hwang et al. [43]
2005
M
23
2.8
Anterior
Lump
Transoral

Lopez-Jornet and Bermejo-Fenoll [44]
2005
M
39
0.8
Posterolateral/base
Lump
Transoral

Vafiadis et al. [45]
2005
M
18
3.1
Anterior
Lump
Transoral

Bansal et al. [46]
2005
M
26
4
Posterolateral/ventral
Paresthesia/dysphonia
Transoral

Hsu et al. [7]
2006
M
20
5
Posterior/base
Bleeding
Transoral

Ying et al. [47]
2006
F
26
4
Posterior/base
Dysphagia/otalgia
Transoral

Enoz et al. [48]
2006
M
7
2.5
Anterior/base
Dysphagia/pain
Transoral

Mehrzad et al. [49]
2006
M
49
2.2
Posterior/ventral
Pain
CO2-transoral

Batra et al. [50]
2007
M
30
3
Posterolateral/base
Dysphagia, dyspnea, abscess
Transoral

Ballesteros et al. [51]
2007
F
31
2
Base
Pain
CO₂-transoral

Sawhney et al. [52]
2008
F
37
4.6
Posterolateral/base
Dysphagia/snoring
Submandibular

Sethi et al. [53]
2008
F
28
1
Anterolateral/ventral
Lump
Transoral

Pereira et al. [54]
2008
M
12
1.5
Posterolateral/ventral
Lump

Cohen and Wang [55]
2009
M
77
0.7
Posterolateral/ventral
Lump
Transoral

Gupta et al. [56]
2009
F
18
1
Anterior/ventral
Lump
Transoral

Mardanpour and Rahbar [57]
2009
M
18
2
Posterior
Dysphagia/change of voice
Transoral

Karaca et al. [58]
2010
F
13
2
Posterolateral/ventral
Dysphagia
Transoral

Cigdem et al. [59]
2010
M
13
2
Anterior/ventral
Lump
Transoral

Jeffcoat et al. [60]
2010
M
68
1.5
Lateral
Lump
Transoral

Naidu and Sinha [61]
2010
M
12
2
Anterolateral/base
Paresthesia/bleeding/ulceration
Transoral

Lukšić et al. [62]
2011
M
10
1.5
Posterolateral/ventral
Lump
Transoral

Batra et al. [63]
2011
F
38
4.2
Posterior/ventral
Dysphagia/change of voice
Transoral

Nisa et al. [64]
2011
F
38
8.5
Posterolateral/ventral
Dysphagia/dysphonia/dyspnea
Transoral

Monga et al. [65]
2013
M
20
2
Posterolateral/base
Lump
Transoral

Lira et al. [5]
2013
F
26
2.5
Posterior/ventral
Cervical pain
Transoral

Erkul et al. [66]
2013
M
21
3
Posterolateral/ventral
Chewing difficulty
Transoral

Jayaraman et al. [67]
2013
F
25
3
Anterolate
Lump
Transoral

George et al. [4]
2014
M
26
4
Posterolateral/base
Dysphagia/dysphonia
Transoral

Bhola et al. [11]
2014
F
14
1.5
Anterolateral/ventral
Lump
Transoral

Moreno-Garcíaet al. [68]
2014
F
13
2
Anterior/ventral
Lump
Lipsplit/mandibulotomy

Nibhoria et al. [69]
2015
F
18
1.5
Posterolateral/ventral
Lump
Transoral

Gopalakrishnanetal. [70]
2016
M
32
3
Posterolateral/ventral
Dysphagia
Transoral

Sharma and Rai [71]
2016
F
20
4
Posterolateral/ventral
Dysphagia/dysphonia
Transoral

Kavčič and Božič [72]
2016
F
20
1.3
Anterolateral/ventral/tip
Lump
Transoral

Lee et al. [73]
2016
M
28
4
Posterior/ventral
Lump
Transoral

Zain et al. [12]
2016
F
24
Not clear
Posterior
Lump
Transoral

Steffi Sharmaetal.
2018
F
20
4
Posterior
Lump
Transoral

Current
2019
M
28
4
Posterior
Lump
Transoral

In the literature review of 61-year period (from 1959 to 2019), 68 cases schwannoma of the tongue were found, and 54% of them are male, and the rest of them are female. More than half of the cases were posterior tongue schwannomas (56%). According to this review, the patients had feeling of lump cases, respectively.

The mean age at diagnosis was nearly 25 years. Transoral excision was performed in 96% cases. However, for two cases, carbon dioxide laser was used for the tongue-base schwannoma, and in three cases, submandibular approach was used. There was no report of recurrence.

Clinically, the schwannomas may be indistinguishable from other encapsulated benign tumors, because biopsy and histological examination are essential to formulate a correct diagnosis. An excisional biopsy was performed to formulate a correct diagnosis and finally find out that the case was uncomplicated. Imaging has become an integral part of evaluation for tongue base lesions, and thus, a systematic imaging approach should be considered. As demonstrated in Fig. 9, lesions of the tongue can be divided into infectious, neoplastic, and congenital categories. An infectious process, such as an abscess, appears hyperintense on T2WI with a thick rimenhancing margin [12]. The present case was totally asymptomatic before surgery, and there was no major complication of surgery. The option of complete resection was chosen on the basis of the size of the lesion and the age of the patient.

Figure 9: Base of the tongue lesions can be subcategorized as above.

5. Conclusions

Diagnosis of schwannoma should be considered for a smooth, painless, firm swelling in the tongue. A schwannoma of the tongue may grow large enough before producing any symptom. Total excision is the treatment of choice particularly in a young patient as it continues to grow. Most of the cases can be completely excised transorally. Total surgical excision of the lesion does not result in any recurrence.

Conflicts of Interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

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