Ethnomedicinal Use, Phytochemistry, and Other Potential Application of Aquatic and Semiaquatic Medicinal Plants

Medicinal plants have been treating various ailments and diseases since ancient times. Aquatic and semiaquatic medicinal plants play an essential role in human welfare to fulfill their daily needs. They have shown biological, pharmacological, nutraceutical, and commercial applications. This review aims to collect and update all recent information on ethnomedicinal, phytochemistry, pharmacological activities, and nanoparticle synthesis and their uses in aquatic and semiaquatic medicinal plants. Original research papers, review papers, short communications, and book chapters on aquatic and semiaquatic plants have been retrieved from PubMed, Web of Science, Scopus, and Google Scholar. Keywords, ethnomedicinal studies, phytochemistry, pharmacological activities, and nanoparticle synthesis from aquatic and semiaquatic medicinal plants are used for the search. Different aquatic and semiaquatic medicinal plants belonging to the families Acanthaceae, Alismataceae, Amaranthaceae, Apiaceae, Araceae, Asteraceae, Boraginaceae, Ceratophyllaceae, Cyperaceae, Fabaceae, Hydrocharitaceae, Lythraceae, Marsileaceae, Menyanthaceae, Nelumbonaceae, Nymphaeaceae, Onagraceae, Plantaginaceae, Poaceae, Polygonaceae, Pontederiaceae, Primulaceae, Scrophulariaceae, and Zingiberaceae have been studied. They are rich in alkaloids, flavonoids, terpenoids, phenolics, saponins, tannins, dietary fiber, glycosidic derivatives, carbohydrates, and proteins. These phytochemicals have been used for their antimicrobial, antioxidant, hepatoprotective, sedative, anticonvulsant, cytotoxic, antiparasitic, and antidiabetic activities. Besides this, various parts of the plants are used as dietary supplements and green nanoparticle synthesis. These plants are also known for their commercial value and are used as an ingredient in some pharmaceutical industries.


Introduction
Natural products from medicinal plants are known for their various uses, such as treating infectious diseases, biological applications in the industry as ingredients, food additives, and green synthesis of nanomaterials [1,2]. About 500,000 plants worldwide have a promising potential for their medical activities [3][4][5][6]. Great civilizations such as Mesopotamian, Roman, Greek, Inca, Indus valley, Sindhu, Ghati, and Mohanjordo indicated that humans always preferred to live near plants, streams, lakes, and different types of water bodies to get their foods and shelters. For example, various plant species and their parts have been reported to be used as human and animal diets and sources of medicine [1,7,8]. Aquatic and semiaquatic plants are found in all ecological zones; however, most are distributed in subtropical and tropical regions. Aquatic medicinal plants can be divided into two categories based on their habitat. ey are aquatic plants and semiaquatic plants. Aquatic plants grow mainly in water bodies or floating on water bodies like algae, whereas semiaquatic plants/amphibian plants prefer to grow in submerged water bodies. Aquatic plants can be classified into two categories based on their ethnomedicinal applications and physicochemical effects. Major aquatic medicinal plants have very high medicinal and economic values and are readily available for commercial purposes for different human welfare. Minor aquatic plants are those plants that still contain therapeutic qualities against multiple diseases and disorders, but either lack availability or have little knowledge regarding their pharmacological properties. is is due to the lack of availability of these plant materials, regional applications of plants, and the economic value of plants, unnoticed or overlooked or neglected by the researchers. However, these plants are highly rich in diversified secondary metabolites due to their association with water bodies and weather conditions [9]. Medicinal plants from the wetland ecosystems have played a vital role in the development of the world since the beginning of human civilization [10]. Aquatic and semiaquatic plants have also been reported with significant prospects for commercial and environmental protection by exploring their hidden riches of medicinal properties [11]. ese plants are highly diversified in structural adaptations, distribution, and phytochemical compound syntheses, enabling them to thrive in the diet and numerous applications [12] (Table 1). Aquatic and semiaquatic medicinal plants have multifunctional bioactive compounds widely used to protect against human and livestock health disorders [41].
Aquatic and semiaquatic medicinal plants and their phytochemicals have been widely practiced as traditional medicines worldwide. For instance, 50-60% of people in India live closer to aquatic bodies and use these plants for various practices such as medicinal, ornamental, and religious offspring [10,41]. Recently, the research interest in aquatic and semiaquatic plants has grown tremendously, increasing the screening of new possible phytoconstituents and the usage of bioactive compounds in approved pharmaceutical drugs. Various literature reports also demonstrated that plants possess high nutritional values, medicinal uses, and several biological and pharmacological activities due to their production of potentially bioactive compounds [46]. Despite the wide range of published documents on aquatic and semiaquatic medicinal plants, the information is scattered and unavailable in one place. erefore, this review aims to bring all the published documents in one place in the form of a review paper.

Some Significant Aquatic and Semiaquatic
Medicinal Plants

Acorus calamus (Sweet Flag).
Sweet flag is an important aquatic medicinal plant belonging to the Araceae family, as shown in Figure 1. It is distributed in marshy areas, shallow lands, and ponds of tropical and subtropical areas such as Asia, Europe, and America [47,48]. is herb has been used in the Indian Ayurvedic medical systems from earlier civilizations. Many parts of this plant, such as rhizomes, roots, and leaves, are used for their medicinal properties. Sweet flag has been used to treat skin disorders, epilepsy, asthma, diarrhea, hysteria, insanity, insomnia, melancholia, neurasthenia, heart disease, and lung cancer [10]. It contains medicinally essential alkaloids such as choline, acorin, calamine A, bitter glycosides, caramel, gum, resin, and starch tannins [47,49]. e primary chemical constituents such as β-asarone (27.4-45.5%), acorenone (20.86%), and isocalamendiol (12.75%) are reported from its leaves and rhizomes, respectively [50,51].

Ageratum conyzoides (White Weed).
is semiaquatic plant species belong to the Asteraceae family ( Figure 2), distributed in tropical and subtropical regions, including Brazil [52]. It is common in Asia, West Africa, and South America. Its leaves and shoots treat fresh cuts and injuries and are used in preparing traditional hair lotion. It also treats pneumonia, wound healing, and skin diseases. Some secondary metabolites also found in the plant are rutin, quercitrin, avicularin hyproside, and catechin [53].

Amomum aromaticum (Namra).
is aquatic medicinal plant belongs to the Zingiberaceae family ( Figure 1), distributed in Bhutan, North East India, and Nepal [57]. It is a common spice and food flavoring agent in Vietnam and other Asian countries [58]. Seeds of the plant exhibit medicinal value for controlling blood pressure. e stem of this plant is consumed in a vegetable diet in Manipur [57]. e plant contains secondary metabolites such as 1,8-cineole, β-myrcene, α-terpineol, terpinene-4-ol, α-pinene, and β-pinene [59].

Bacopa monnieri (Water Hyssop).
is aquatic plant species belong to the Plantaginaceae family and is native to India, the United States, East Asia, and Australia, as shown in Figure 1.

Centella asiatica (Indian Pennywort).
is aquatic medicinal plant belongs to the Apiaceae family ( Figure 1), found in most tropical and subtropical countries, including India, Pakistan, Sri Lanka, Madagascar, South Africa, South Pacific, and Eastern Europe [62]. Leaves, flowers, and fruits of the plant have many medicinal uses and are used to treat various skin diseases, fever, strangury, and brain health [63][64][65].
e active phytoconstituents found in this plant include triterpenes hydrocarbons [66].

Centipeda minima (Spreading Sneezeweed).
is aquatic medicinal plant belongs to the Asteraceae family ( Figure 1). It is found in wet places and the rice fields of most Asian countries [67]. e leaves and roots of the plant are used to treat various diseases. It is widely used for antibacterial, antioxidant, anti-angiogenic, and anticancer activities [68,69]. It contains secondary metabolites such as lactones, sesquiterpenes, and triterpenes [70].

Coix lacryma-jobi (Job's Tears).
is aquatic medicinal plant belongs to the Poaceae family ( Figure 1). It is distributed throughout Asian countries and is a native plant of Southeast Asia. Leaves, flowers, and fruits are used as a diet supplement to treat chicken pox, stomachache, and menstrual disorders [33]. It is also reported to possess analgesic and antispasmodic properties [72]. e plant contains triglyceride, β-sitosterol, stigmasterol, and phytyl fatty acid ester [73].

Eclipta prostrate (False Daisy).
is semiaquatic plant belongs to the family of Asteraceae ( Figure 2). It is a native plant of Asia and is also distributed in tropical, subtropical, and warm temperate regions of the world [74]. e plant is used to cure eczema, headache, jaundice, mental disorders, scorpion sting, skin diseases, snakebite, spleen enlargements, and toothache. It also showed antiulcer properties. Secondary metabolites present in this plant are triterpenoids, thiophenes, coumestans, flavonoids, and steroids [75].

Eleocharis dulcis (Water Chestnut).
is semiaquatic medicinal plant is commonly known as the Chinese water chestnut and belongs to the Cyperaceae family ( Figure 2). e plant is commonly grown as a vegetable in Japan, China, India, and other Asian countries [76]. e plant contains phytochemicals such as carbohydrates, flavonoids, proteins, and minerals [77]. e plant treats amenorrhoea, hernia, nausea, abdominal pain, cardiac risks, liver problems, constipation, pharyngitis, laryngitis, hypertension, and chronic nephritis [74,78].

Enhydra fluctuans (Water Cress).
is aquatic medicinal plant belongs to the Asteraceae family ( Figure 1). e plant grows in the marshy areas of tropical and subtropical regions of Asia and Africa [79]. is plant species prefers to grow along with ponds, waterways, ditches, and rice fields [80]. Leaves of the plant are a rich source of protein and are used to treat diseases such as nervous diseases [81], skin diseases, and smallpox [82]. e plant leaves possess antioxidant properties [83]. e plant consists of various secondary metabolites: ethyl acetate, n-butanol, baicalein-7-O-glucoside, and baicalein 7-O-diglucoside [84].

Heliotropium indicum (Indian Heliotrope).
is semiaquatic medicinal plant belongs to the Boraginaceae family ( Figure 2). e plant is known as Indian heliotrope, distributed in tropical, subtropical, and warm temperate zones [87]. Flowers, shoots, and whole plant parts exhibit medicinal properties and treat asthma, boils, bronchitis, cataract, dysentery, menstrual blood loss, redness and conjunctivitis of the eyes, antiseptic, scorpion sting, and ulcers [88].

Limnophila aromatica (Rice Paddy Herb).
is semiaquatic medicinal plant is known as the rice paddy herb and belongs to the family Plantaginaceae, as shown in Figure 2. It is widely used in Southeast Asia, including Vietnam, Malaysia, and ailand [96]. It treats various diseases such as dysentery, elephantiasis, fever, indigestion, intestinal worms, menstrual problems, and mucus removal. e plant also has antimutagenic and antitumor properties. It contains starch, dietary fiber, protein, polysaccharides, and lignin [97].

Ludwigia adscendens (Water Primrose).
is semiaquatic medicinal plant belongs to the Onagraceae family ( Figure 2). e plant species cure dysentery, skin diseases, and ulcers. e whole plant has been reported for its emetic, laxative, anthelmintic, antidysenteric, anti-inflammatory, antioxidant, and antimicrobial properties [82]. Phytochemicals such as squalene, betulonic acid, betulin, betulinic  Evidence-Based Complementary and Alternative Medicine acid, and quercetin derivatives are some constituents reported from the plant extract [98].

Marsilea minuta (Water Clover).
is aquatic medicinal plant belongs to the Marsileaceae family ( Figure 1). It is popularly known as water clover and is distributed worldwide [99,100]. Leaves of the plant are used to treat headaches, migraine, respiratory diseases, hypertension, muscle tension, and sleeping disorders [101][102][103]. ey also treat chronic cancer and cardiovascular diseases [104]. e leaves and roots of this plant have medicinal values to treat indigestion, kidney infection, nose bleeding, diarrhoeal, cough, hepatitis, headache, hypertension, insomnia, sleeping disorder, and skin diseases [105]. e plant species is also known for its potent antioxidant and antibacterial activity [106]. It consists of many secondary metabolites such as carotenoids, flavonoids, cinnamic acids, benzoic acids, folic acids, ascorbic acids, tocopherols, and tocotrienols [107,108].

Nymphaea nouchali (Blue Water-Lily).
is aquatic medicinal plant belongs to the Nymphaeaceae family, as shown in Figure 1. Plant parts such as leaves, roots, rhizomes, fruits, flowers, and tubers treat liver, kidney, and heart diseases. It is also known for antimicrobial, antidiabetic, and Evidence-Based Complementary and Alternative Medicine antioxidant activities [113,114]. It is widely distributed in South Asian countries, Australia, and Africa [115]. Plant extracts are reported to contain rutin, catechin, myricetin, ellagic acid, gallic acid, vanillic acid, rosmarinic acid, p-coumaric acid, quercetin, and ascorbic acid [116,117].

Pistia stratiotes (Water Lettuce).
is aquatic medicinal plant belongs to the Araceae family ( Figure 1). e plant species are commonly found in stagnant water (lakes and rivers) throughout Asia and subtropical Asia, Africa, and America [124]. e leaves and roots of the plant have very high medicinal values and are used for curing many diseases such as kidney disorders, leprosy, dysentery, eczema, and ulcers. Its extracts contain secondary metabolites such as phenolics and tannins [125].

Rotula aquatic (Aquatic Rotala).
is aquatic medicinal plant belongs to the Boraginaceae family (Figure 1). e plant species is native to India, China, and Malaysia and is also found in Africa and South America [126]. e plant species is a remedy for blood disorders, coughs, dysuria, fever, and heart diseases. e plant's leaves and flowers can be used to treat diabetes, bladder and kidney stones, piles, and venereal diseases. [41]. e plant extracts contain secondary metabolites such as allantoin, baurenol, and kaempferol [126].

Rumex maritimus (Torong-Khongchak).
is aquatic medicinal plant belongs to the Polygonaceae family (Figure 1). It is widely distributed throughout Bangladesh, India, North Africa, and America [128]. e leaves, roots, and stems of the plant have medicinal values. Leaves paste of the plant is applied to cure leucoderma, burns, and injuries [15], and the roots are used to treat diarrhea [128]. 2-Methoxystypandrone is the commonly reported secondary metabolite present in the plant [129].

Sagittaria sagittifolia (Koukha).
is aquatic medicinal plant belongs to the Alismataceae family ( Figure 1). It is the only native species of the genus Sagittaria in Czechoslovakia.
e remaining species of this genus occur mainly in tropical and subtropical regions. It predominates in North America, Europe, and Asia [130]. It is mainly found in Asian countries, including China, Bangladesh, Indonesia, Malaysia, Nepal, Sri Lanka, Philippines, ailand, Vietnam, Cambodia, and India. Root past showed medicinal uses to treat cough and fever. e plant species contain polysaccharides as the main phytochemical components [131].

Sphaeranthus indicus (East Indian Globe
istle). is aquatic medicinal plant belongs to the Asteraceae family ( Figure 1). e plant is widely distributed in India, Sri Lanka, and other continents like Australia and Africa [132]. It prefers to grow in dry or wet places. Various parts of this plant, including seeds, leaves, flowers, and roots, have many medicinal properties widely used to treat disorders like asthma, chest pains, chronic skin diseases, cough, and mental disorders [41]. Triterpenoids, resin, saponins, tannins, and steroids are the primary reported secondary metabolites present in the plant species [133].

Spilanthes calva (Toothache Plant).
is semiaquatic plant species belong to the Asteraceae family ( Figure 2). e plant species are distributed in some parts of India [134]. Flower head, roots, and whole plant part have medicinal values that cure dysentery, psoriasis, purgative, rheumatism, scabies, stammering in children, tongue paralysis, and toothache. e plant extracts have antioxidant and cytotoxic properties [135]. Saturated and unsaturated alkyl ketones, alkamides, hydrocarbons, acetylenes, lactones, alkaloids, terpenoids, flavonoids, and coumarins are the main phytochemicals present in the extract of the plant species [136].   Evidence-Based Complementary and Alternative Medicine 9

Phytochemistry of Aquatic and Semiaquatic Plants.
Aquatic and semiaquatic plants contain many phytochemical compounds responsible for their multifunctional properties [139]. Due to their wide-spectrum chemical properties, these plants possess potential medicinal, biological, pharmacological, and other applications [16,140]. Phytochemical studies on some aquatic and semiaquatic plants revealed various organic compounds with various chemical structures and functional groups. Some phytochemical compounds reported from the extracts of aquatic and semiaquatic plants are given in Figure 3.

Uses of Aquatic and Semiaquatic Medicinal Plants
Natural products produced by aquatic and semiaquatic medicinal plants are known for their potential biological applications and diet supplements. Aquatic and semiaquatic plants are often used as medicines for many health disorders and diet supplements due to their nutritional values and medicinal uses, and in pharmaceutical industries for producing herbal-based cosmetic products [  diversified chemical and biological properties make them medicinally valuable and increase their demand globally. Some previous studies regarding the importance of aquatic and semiaquatic medicinal plants for biological, industrial, and other applications are discussed and presented in Figure 4.

Antioxidant Activity.
Aquatic and semiaquatic medicinal plants are known for their potential antioxidant properties. Earlier reports showed that the reducing power of essential oil of Hedychium coronarium might be strongly correlated with their antioxidative activities [85]. Some literature reported that the phytoconstituents of Bacopa monnieri showed good antioxidant properties [147]. Epifano and his coworkers (2015) reported that the Nymphaea nouchali is a rich source of antioxidants. Potential antioxidant compounds are identified from the extracts of Centella asiatica, Ipomea aquatic, Nelumbo nucifera, Nasturtium officinale, and Ludwigia adscendens. Phytochemical compounds with antioxidant properties were found in aquatic and semiaquatic plant species such as Persicaria hydropiper, Rotula aquatic, Sphaeranthus indicus, Polygonum glabrum, Ammannia baccifera, Ipomea aquatic, Nymphaea nouchali, Acorus calamus, Hedychium coronarium, Heliotropium indicum, Marsilea minuta, and Vetiveria zizanioides [107,[148][149][150][151].  Evidence-Based Complementary and Alternative Medicine hepatoprotective activity than control groups [152]. e ethyl acetate extract of Enhydra fluctuations was found to have more potent hepatoprotective effects due to its potential flavonoid compounds. Phytoconstituents from Marsilea minuta plant species displayed significant hepatoprotective effects [108]. e protective effect of a methanolic extract of S. indicus against CCl 4 -induced hepatotoxicity was reported [153]. e ethanolic extract of Nymphoides hydrophylla was checked against CCl 4 -induced liver injury in albino rats and demonstrated impressive hepatoprotective activity [154]. Hepatoprotective studies of extracts of Hygrophila auriculata checked against HepG2 cells and paracetamol-induced hepatotoxicity and found that it improved hepatoprotective effects. [94]. e ethanolic extract of Ipomoea aquatic has been reported to effectively prevent thioacetamide-induced hepatic damage in animal models [155].

Sedative Activity.
e natural products from Marsilea minuta [108], rhizome extract of Acorus calamus [149], and petroleum-ether extract of root parts of Hygrophila schulli [95] showed promising sedative activity. Bacopa monnieri and Enhydra fluctuans plant species have potential sedative actions [156,157]. e alcoholic extract of Sphaeranthus indicus has been reported with significant sedative activity compared to standard sedative pentobarbitone and diazepam in the Swiss albino rat model [142,153]. In the Ayurvedic system, the Acorus calamus plant is known as a magic root due to its sedative effect [158]. Various literature findings displayed that Cyperus tegetum has been used by tribal people for the treatment of mental disorders such as epilepsy [159,160]. Sharma and coworkers (2020) displayed that extracts and compounds from the Acorus calamus demonstrated anticonvulsant activity with significant signaling pathways. For instance, methanolic and acetone extracts of Acorus calamus leaves have shown promising anticonvulsant activity [161]. e roots and rhizomes of the Acorus calamus also possess significant anticonvulsant activity [158]. Several pieces of the literature indicated that Cyperus tegetum plant has anticonvulsant activity [159,160]. e aqueous and alcoholic extracts of roots and rhizomes of Nymphoide indica exhibited effective anticonvulsant activity [154]. Hydroalcoholic extract of Sphaeranthus indicus plant species showed anticonvulsant effects in the earlier studies [142].

Anticonvulsant Activity.
3.6. Cytotoxic Activity. Samanta and coworkers (2020) reported that extract from the aerial part of Ipomea aquatic showed a cytoprotective role in the liver and other organs [162]. Methanolic and aqueous extracts of the Acorus calamus have been known for their cytotoxicity effects [158,163]. e methanol extract of Mollugo cerviana, Trichosanthes cucumerina, and Vetiveria zizanioides plants have been reported for their cytotoxicity against cancer cells such as HeLa and MCF-7 cell lines [151]. Alcoholic extracts of Enhydra fluctuations, Andrographis peniculata, and Clerodendrum viscosum exhibited potent cytotoxicity against brine shrimp compared to ampicillin trihydrate as a positive control [164,165]. e ethanolic extract of Centella asiatica exhibited weak cytotoxicity effects compared to the standard drugs [64].

Antiparasitic
Activity. Several studies on aquatic and semiaquatic medicinal plants show their antiparasitic properties. Nymphoides plant species possess antiprotozoal, antimalarial, and anthelmintic properties [154]. Organic solvent extracts of various parts of the genus Spilanthes, such as dichloromethane extract of flowers, methanol extract of flowers, and cold dichloromethane extract of plant stems, have been shown to have significant activity against malaria and sleeping sickness diseases [136].

Antidiabetic
Activity. Different plant extracts treat diabetes mellitus [166][167][168]. Centella asiatica, Hedychium coronarium, Ipomea aquatic, Pistia stratiotes, Spergularia marina, and Nymphaea nouchali have been reported as medicinal plants with effective antidiabetic properties due to their potency in the wide range of bioactive compounds [41,169]. Ethyl acetate extracts and pure compounds obtained from Acorus calamus plant species have been reported for their strong antidiabetic effects [170]. e shoots and roots of Ipomea aquatic are also used to treat diabetes [171].

As a Dietary Supplement.
Several aquatic and semiaquatic plant species are available as food using their various parts, such as stems, leaves, roots, rhizomes, flowers, flower heads, and fruits. For example, the edible part of Oryza sativa (rice) is its grain. In contrast, the leaves of Nasturtium officinale (Watercress), Neptunia oleracea (Water mimosa), and Oenanthe javanica (Japanese parsley) are used as human food [117]. Some previous studies revealed that Enhydra fluctuation, an edible semiaquatic herbaceous vegetable, is a rich source of phytochemicals such as β-carotene and ascorbic acid, which are required in diet supplements [172]. Ipomea aquatic is commonly used as a leafy vegetable or salad, which contains medicinally important flavonoids, alkaloids, and carotenes [10]. e leaves, roots, fruits, flowers, rhizomes, and tubers of Nymphaea nouchali plant species have been eaten in times of food scarcity [10,41]. Ludwigia adscendens plant has been known to be consumed in the vegetable diet in China [173]. Leaves and tender shoots of the underutilized Alternanthera sessilis plant species are used in the vegetable diet for their potential nutritional and medicinal values [174]. Chia and coworkers (2015) reported that the leaves of the Alternanthera sessilis plant had been consumed raw or cooked as a food supplement [173]. Seaweeds are used for making a variety of foods. For instance, major aquatic and semiaquatic plant species that have been reported as human food includes Acorus calamus, Aeschynomene aspera, Alternanthera philoxeroides, Centella asiatica, Colocasia esculent, Cyperus rotundus, Eleocharis dulcis, Hydrolea zeylanica, Hygroryza aristata, Nymphoides hydrophylla, Oryza sativa, Pistia stratiotes, Polygonum plebeium, Trapa natans, Vallisneria spiralis, and Spilanthes calva [41].

As Industrial/Commercial Products.
e use of macroalgae in pharmaceutical industries showed their importance for humans as they were applied as antibiotic, antifouling, antiviral, anti-inflammatory, cytotoxic, and antimitotic agents. e flour of fruits of Trapa bispinosa is reported to have important commercial uses in the milk industry and as a filler in the pharmaceutical industry [169]. Similarly, the rhizome extract and essential oils of the Acorus calamus are widely used in the flavoring industry and for commercial purposes [149,175].

In the Green Synthesis of Metallic Nanoparticles.
Nanoparticles have more advanced properties than bulk materials due to their superior behavior with defined shape and size [176]. e increased surface-to-volume ratio and quantum size effect properties of metal/metal oxide nanoparticles are the main reason for their chemical activity, strength, and other novel characteristics [177]. e synthesis of green metal/metal oxide nanoparticles is less likely to produce environmentally hazardous byproducts.
is is primarily due to the plant-derived mediated reducing, capping, and stabilizing agents. [178]. Currently, many researchers have inclined their interests toward the secondary metabolites from various parts of plants as a route of synthesis of metal/metal oxide nanoparticles [179]. Green metal/metal oxide nanoparticles are highly used in various applications such as antibacterial, antioxidant, anti-inflammatory, catalytic, and cytotoxic activities [180]. Even though few studies have been carried out on the green synthesis using aquatic and semiaquatic plant extracts, some earlier studies revealed that these plants are rich sources of stronger bioreductants for synthesizing metallic nanoparticles. Aquatic and semiaquatic plants mediated green synthesis of metallic nanoparticles showed a faster reaction process than other plants [181]. Mathur et al. described the synthesis of silver nanoparticles (AgNPs) using extracts of Alternanthera sessilis and Withania somnifera for their applications in the assays of cytotoxicity effects and antibacterial activities with promising results [182]. e phytochemicals from the stem, fruit, seeds, leaves, and flowers of Alternanthera sessilis have been used for the biosynthesis of gold nanoparticles (AuNPs) and AgNPs. ese synthesized nanoparticles have antibacterial, antifungicidal, antiplasmodial, anti-inflammatory, anticancer, antidiabetic, antiviral, and antioxidant activities [183]. Other studies also displayed that AgNPs synthesized from extracts of Alternanthera sessilis demonstrated significant cytotoxicity effects on the breast cancer cells [184].

Conclusions and Future Prospectives
Aquatic and semiaquatic medicinal plant products have remarkable biological, pharmacological, agricultural, green materials synthesis, and industrial applications. ey are also used as nutraceuticals, food, and medicine. ese plants contain diverse natural compounds with numerous biological and chemical properties. Crude extracts or pure compounds from various parts of aquatic and semiaquatic plants possess potential nutritional and medicinal values. Phytochemicals are widely used to treat various infectious and noninfectious health ailments. Further, several aquatic and semiaquatic plants are used for the green synthesis of metal and metal oxide nanomaterials, which have shown many potential applications. Moreover, they are also helpful for various commercial product preparations. Even though these plant species have a wide range of phytochemicals with potential bioactive properties, enough research work is missing. us, this review article was designed. However, in the future, more extensive and specific research is required to investigate the natural phytochemicals from these aquatic and semiaquatic medicinal plants for various commercial uses.

Data Availability
No data were used to support this study.

Conflicts of Interest
e authors declare that there are no conflicts of interest regarding the publication of this review article.

Authors' Contributions
AKA, MD, D, KKJ, and AB originated the idea, drafted, and wrote the review. YHG prepared different figures and tables and revised the manuscript. RKB and AH guided the development of the idea and revised the manuscript. All the authors read and approved the final manuscript.