Retracted: Clinical Analysis of Video-Assisted Thoracoscopic Surgery for Resection of Solitary Pulmonary Nodules and Influencing Factors in the Diagnosis of Benign and Malignant Nodules

[This retracts the article DOI: 10.1155/2021/1490709.].

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Introduction
Solitary pulmonary nodules (SPNs) are round or round-like lesions ≤30 mm in diameter within the lung parenchyma and are not associated with significant pulmonary atelectasis, satellite lesions, pleural effusion, or lymph node enlargement [1].*e detection rate of SPN is showing an increasing trend with the improvement of people's awareness of physical examination and the development of imaging technology.*e emergence of SPN is often a sign of lung metastasis of early lung cancer or other malignant tumors and needs to be removed in time to avoid delaying the disease.However, early diagnosis can avoid unnecessary surgery for benign SNP [2].It can be seen that early diagnosis of SPN and selection of the best treatment plan in the process of clinical practice are important ways to treat patients with lung tumors and reduce their mortality.
*e diagnosis and differentiation of isolated pulmonary nodules is difficult, and the combination of imaging and pathology, such as magnetic resonance imaging (MRI), computer tomography (CT), and X-ray, is often used in clinical practice to implement the diagnosis and

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management, but there is not a high positive detection rate [3].*e open-chest surgical exploration operation is a common and practical intraoperative diagnostic method, but this procedure can cause greater trauma to the patient's body and is prone to various postoperative complications such as lung infection.In addition, open-heart surgery usually takes a long time, which increases the risk of surgery and requires a long postoperative period of intrathoracic drainage, which has a serious impact on the patient's quality of life and is not conducive to early recovery [4,5].Videoassisted thoracoscopic surgery (VATS) surgical approach is less traumatic, with fewer postoperative complications, avoiding additional nerve and tissue damage to the patient, and better postoperative rehabilitation, and diagnosis and treatment can be performed at the same time.*e patient does not need to undergo a second operation, which reduces the burden on the patient to a greater extent and avoids repeated inspections and delays in treatment [6,7].In this study, we retrospectively analyzed 317 cases of SPN patients undergoing VATS surgical resection and pathological diagnosis of benign and malignant SPN in our hospital and explored the efficacy of VATS and related factors affecting the diagnosis of benign and malignant SPN.

General Information
. *e clinical data of 317 patients with SPN who were surgically resected by VATS and confirmed benign and malignant by pathology at our hospital from January 2017 to December 2019 were retrospectively analyzed.Among them, 176 males and 141 females were aged from 38 to 70 years, and the average age was (54.83 ± 10.29) years.*ere were 68 patients who had symptoms of cough and sputum; 89 patients had symptoms such as chest tightness, chest pain, and low-grade fever; and 164 patients had no abnormal symptoms and SPN were found through health examination.*ere were 127 cases with a history of smoking and 26 cases with a history of previous tumors, and the maximum diameter of the nodule was (22.81 ± 5.34) mm.*ere were 96 cases in the right upper lobe, 31 cases in the right middle lobe, 58 cases in the right lower lobe, 79 cases in the left upper lobe, and 53 cases in the left lower lobe according to the classification of the lesion.

Inclusion Criteria.
(i) *e maximum diameter of SPN is ≤30 mm.(ii) *e patient's clinical surgery, pathological data or imaging follow-up data are complete.(iii) *e patient has no symptoms such as pleural effusion, obstructive pneumonia, satellite lesions, or hilar mediastinal lymphadenopathy.

Surgical Methods
. *e patient's routine clinical examination data and chest CT enhanced examination data were sorted out before surgery.*e patients were placed in a 90 °lying position on the contralateral side when performing VATS.Double-lumen endotracheal intubation was performed, and the contralateral side was used for single-lung ventilation.*e surgical method of single-port VATS was as follows: A small 3 cm incision was taken at the mid-axillary line of the fifth intercostal space, and the operations such as insertion of a thoracoscope and all surgical instruments were passed through this hole.In the porous VATS, a 1.2 cm incision was taken from the mid-axillary line of the seventh intercostal space as the observation hole, and a thoracoscope was inserted.A 3-4 cm incision was made between the anterior axillary line and the mid-axillary line of the fourth intercostal space on the surgical side as the operating hole, and surgical instruments were inserted.For patients who have had a pathological diagnosis of malignant tumors before surgery, segmentectomy, lobectomy, or wedge resection was performed according to their lung function, and the corresponding regional lymph nodes were cleared.Lung wedge resection should be performed first, and a quick frozen pathological examination should be done for patients who have no pathological diagnosis before surgery.*en, choose whether to perform lobectomy and lymph node dissection according to the benign and malignant results of the lesion after the frozen pathological report during the operation.

Observation Index
. *e surgical resection of all patients and the differences in postoperative conditions such as operative time, intraoperative blood loss, chest drain retention time, postoperative hospital stay, and complication rate between patients undergoing single-port VATS and multi-port VATS were observed and recorded.Logistic regression models were used to analyze the factors associated with the diagnosis of benign and malignant SPN.

Statistical Methods.
All data were processed with SPSS 22.0 statistical software, and GraphPad Prism 8 was used to make statistical graphs.Measurement data were expressed as mean ± standard deviation (x ± s), the independent sample t-test was used for comparison between groups, count data were expressed as [n (%)], and the chi-square (χ 2 ) test was performed.A multivariate logistic regression model was used to analyze the related factors affecting the diagnosis of benign and malignant SPN.*e difference was statistically significant when P < 0.05.

Discussion
*e pathogenesis of SPN is complex, but its occurrence often suggests the presence of early lung cancer and other diseases [8].It is difficult to determine the benign and malignant SPN due to the large difference in clinical symptoms and imaging findings of SPN patients, and we can observe that some SPN imaging examinations show malignant signs, but the pathological diagnosis after surgery shows benign lesions [9].*erefore, it is of great significance to improve the diagnosis efficiency of SPN benign and malignant and adopt corresponding effective treatment methods to improve the efficacy and long-term survival rate of patients [10].
VATS is a mature minimally invasive surgical technique.A number of studies [11,12] showed that VATS is easier to be accepted by physicians and patients in the process of clinical application because it has both small wounds, light postoperative pain, and complications.*e advantages are fewer symptoms and faster recovery after surgery.In this study, we retrospectively analyzed the clinical data of 317 SPN patients who underwent VATS resection and found that 124 patients (39.12%) underwent single-hole VATS and 193 patients (60.88%) underwent multi-hole VATS.Singleport operation is a further development of classic VATS under the concept of minimally invasive and rapid recovery, which has the advantages such as minimizing the incision, optimizing the field of view, and reducing chest wall and intercostal nerve injuries compared with multi-port VATS.However, single-port VATS requires more skill and

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experience from the surgeon [13].Lobectomy was performed in 195 cases (61.51%), anatomical segmental lung resection in 16 cases (5.05%), and pulmonary wedge resection in 106 cases (33.44%) in this study.We performed wedge resection for benign SPN and lobectomy or segmental lung resection and lymph node dissection for malignant SPN, except for three patients who were converted to open surgery intraoperatively due to pleural atresia.*is shows that both benign and malignant SPN can be diagnosed and effectively treated with VATS [14].
No serious adverse outcome events such as death occurred in any patients during the perioperative period.*e three patients who underwent open-chest surgery had a mean operative time of 68.00 minutes, intraoperative blood loss of 123.33 ml, drainage tube retention time of 6.33 days, and postoperative hospital stay of 12.25 days, compared with the two groups of patients who underwent single-port VATS and multi-port VATS, all of which were at similar and lower levels.VATS treatment for benign and malignant SPN is less invasive and has fewer complications, which is conducive to  Evidence-Based Complementary and Alternative Medicine

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the recovery of the patient's body function after surgery, and can complete the diagnosis and treatment at once, avoiding secondary surgery and long-term follow-up repeated examinations [15].After the operation, our physicians discussed and studied many times and summarized the intraoperative experience and precautions that the choice of single-hole or multi-hole VATS should be made according to the individualized situation of the patient and the experience and level of the surgical operator.In cases where patients present with severe thoracic adhesions and difficult exposure, blind adherence to single-port VATS will not only make the procedure more difficult but also lead to prolonged anesthesia and operative time and increased postoperative complications.
All 317 patients in this study were pathologically diagnosed, of which 98 cases (30.91%) were benign nodules, including hamartoma, inflammatory pseudotumor, and tuberculoma most of which were inflammatory pseudotumor and tuberculoma.219 cases (69.09%) were malignant nodules, including squamous cell carcinoma, adenocarcinoma, carcinoid, small cell carcinoma, large cell carcinoma, and adenosquamous carcinoma of which adenocarcinoma and squamous cell carcinoma were the main ones, accounting for 44.75% and 48.86% of malignant SPN, respectively, and TNM staging is mostly stage I. *e above fully confirms that early effective treatments for SPN can achieve better treatment results while confirming the diagnosis, avoiding repeated inspections and treatment delays [16,17].
*e clinical symptoms and imaging features of benign and malignant SPN partially overlap, which brings great difficulties to clinicians in the diagnosis and treatment, and there is uncertainty.However, CT imaging features are still an important basis for diagnosis of benign and malignant nodules [18].*e results of this study show that benign and malignant nodules are significantly different in terms of patient age, nodule diameter, calcification, lobular sign, burr sign, vascular cluster sign, and pleural depression sign.And further analysis showed that age, nodule diameter, lobular sign, burr sign, vascular cluster sign, and pleural depression sign are independent factors affecting the diagnosis of benign and malignant SPN, which suggests that older patients with SPN should be more cautious to the development of early lung cancer and be promptly treated with effective surgical management or closely followed up [19].*e study by Chen et al. [20] showed that the probability of SPN being diagnosed as malignant is significantly increased when its diameter exceeds 10 mm, which suggests that the benign and malignant SPN are significantly related to the diameter of the nodule.Malignant SPN imaging usually shows a gravelly or diffuse distribution with a small extent, while benign SPN imaging shows smooth, intact margins with clear contours [21,22].Studies [23] have pointed out that the signs of malignant lesions in pulmonary nodules include pleural traction, burr sign, lobular sign, tumor vascular sign, bronchus truncation sign, etc., and the results of this study are generally consistent with them.
In summary, VATS is a minimally invasive procedure with few complications and is of great clinical value in the diagnosis and treatment of benign and malignant SPN.Age, nodal diameter, lobar sign, burr sign, vascular collection sign, and pleural depression sign are independent factors affecting the diagnosis of benign and malignant SPN; therefore, patients who are older and have risk factors on

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imaging should be given high priority and managed early and aggressively or followed up closely.

Figure 2 :
Figure 2: Comparison of the postoperative situation of patients undergoing single-port VATS operation and multi-port VATS operation.(a) Comparison of mean operative time.(b) Comparison of mean intraoperative bleeding.(c) Comparison of the mean drainage tube retention time.(d) Comparison of the mean hospital stay.(e) Comparison of postoperative complications.

Table 2 :
Univariate analysis of diagnosis of benign and malignant nodules (n, %).

Table 3 :
Assigned values for multivariate analysis factors.

Table 4 :
Multivariate analysis of diagnosis of benign and malignant nodules.