Article Identification of Pneumonia in Chest X-Ray Image Based on Transformer

The research of application models based on traditional convolutional neural networks has gradually entered the bottleneck period of performance improvement, and the improvement of chest X-ray image models has gradually become a difficult problem in the study. In this paper, the Swin Transformer is introduced into the application model of pneumonia recognition in chest X-ray images, and it is optimized according to the characteristics of chest X-ray images. The experimental results based on the model in this paper are compared with those of the model built with the traditional convolutional neural network as the backbone network, and the accuracy of the model is proved to be greatly improved. After the comparison experiments on two different datasets, the experimental results show that the accuracy of the model in this paper improves from 76.3% to 87.3% and from 92.8% to 97.2%, respectively. The experiments show that the accuracy of image enhancement based on the features of chest X-ray images in this model will be higher than the accuracy without image enhancement. In the experiments of this paper, the identification decision factors in the chest X-ray images were extracted by grad-cam combined with a transformer to find the corresponding approximate lesion regions.


Introduction
Pneumonia is a common and dangerous disease that is mainly caused by viruses, bacteria, or fungi. If left untreated, its mortality rate is high. According to the literature, pneumonia is one of the ten deadliest diseases in the United States and has a higher mortality rate in developing countries [1]. Chest X-ray imaging (hereafter referred to as CXR) is widely used in general routine examinations because it is not only low cost, but also its radiation is less harmful than computed tomography. Relevant papers indicate that the mean e ective radiation dose per exam of CXR is about 0.04 ± 0.19 msv, while the principle of computed tomography is that X-rays penetrate the human body for multiple times for tomography, so the mean e ective radiation dose per exam can reach 1.09 ± 1.11 msv, about 25 times that of CXR [2]. Doctors often use CXR as an important aid in diagnosing pneumonia. In today's world, arti cial intelligence is playing a huge role in the transformation of science, industry, and society, and its techniques are widely used in medical image processing. e application and improvement of arti cial intelligence in CXR to identify pneumonia can assist doctors in making the correct diagnosis, help them speed up the diagnosis, reduce the proportion of missed and misdiagnosis, and be of great importance in saving lives.
Since the explosive development of deep learning in 2012, amazing achievements have been made in the research and application of arti cial intelligence. Compared with other machine learning algorithms, deep learning algorithms can rely on their own learning methods for feature extraction. Deep learning has achieved great success in many elds such as computer vision, natural language processing, and big data analysis. In addition, it has become a mainstream approach to machine learning and has achieved record-breaking results in various competitions in arti cial intelligence. Deep learning can be traced back to AlexNet in 2012 [3]. e accuracy of this convolutional neural network algorithm, which won the championship in the famous international image classification competition ImageNet, has been improved by more than ten points compared with other algorithms in the past. It uses many methods for the first time, uses ReLu as a nonlinear activation function, uses dropout to prevent overfitting, uses data enhancement, and so on. After AlexNet, there have been many excellent convolutional neural networks. VGGNet is a convolutional neural network developed by the Visual Geometry Group of Oxford University on the basis of AlexNet [4]. e improvement of VGGNet is that it uses a smaller convolution kernel and a deeper network structure, which enhances the feature learning ability of the convolutional neural network, which also verifies the advantages of small convolution kernels and can improve network performance by deepening the network structure. In addition, VGGNet uses the multi-Scale method to train and predict, reducing the occurrence of model overfitting and improving the prediction accuracy. Inspired by the Network in Network theory, the concept of the Inception module emerged, that is, a convolutional layer contains multiple convolutional operations of different sizes. A typical convolutional neural network with Inception is GoogLeNet [5]. In addition, two auxiliary classifiers are added to the middle layer of GoogLeNet to strengthen supervision information and alleviate the problem of gradient disappearance. In simple theory, the deeper the network level, the more complex feature extraction can be carried out, so better results should be obtained. But in fact, it was found in the experiment that there was a problem of degradation after the network was deepened to a certain extent, that is, after a large increase in the network depth, the accuracy began to saturate and degrade. e main reason is that when the data are transmitted in a deep network, the gradient becomes smaller and gradually disappears, making it impossible to perform the backpropagation algorithm, so it is difficult for the network to train and find a good parameter after deepening the level to a certain extent. For this reason, He et al. proposed a residual unit with a "shortcircuit connection" structure to solve this degradation problem, instead of directly connecting each layer. ResNet is modified on the basis of VGGNet, and it uses residual units [6]. Compared with VGGNet, it adds a "short-circuit connection" mechanism between every two layers, which gives an implementation idea for building a much deeper network. In addition to the ways of deepening the network such as ResNet and widening the network such as Goo-gLeNet to improve the effect, there are also multiplexing schemes, the typical representative is DenseNet, which can achieve better results while achieving fewer parameters [7]. Other scholars have proposed EfficientNet, which is based on an artificial neural network to obtain the optimal composite coefficient of network depth, network width, and image resolution [8].
With the research and development of the convolutional neural backbone network, it has also promoted the improvement of medical image processing model capabilities. As early as 2017, Wang's team built medical image processing models based on the classic convolutional neural network AlexNet [3], VGGNet [4], GoogLeNet [5], and ResNet [6] in deep learning, and tested and compared them on the public CXR dataset named Chest X-ray. rough their research and experiments, it was proved that resnet50 has the best effect of disease identification in CXR compared with other backbone networks [9]. Yao et al. optimized the convolutional neural network DenseNet [7], and the model they proposed was tested on the Chest X-ray dataset and achieved ideal results [10]. Later, Rajpurkar and other scholars built a 121-layer network based on the convolutional neural network DenseNet and used the weighted cross entropy as the loss function to propose the chexnet model for medical image classification. e model was tested with a higher accuracy score than four human medical imaging experts correctly judged [11]. Later, many scholars further improved the models based on the convolutional neural network according to the features of CXR [12][13][14][15][16][17][18][19][20]. But accuracy of models began to encounter bottlenecks, and there are still some unsolved or imperfect problems in the current models.
In this paper, a new model scheme based on the backbone network of the new transformer and optimized according to the features of CXR will be proposed, and it can greatly improve the accuracy of identification of pneumonia in CXR. e image enhancement and parameter optimization scheme are designed based on the features of CXR, and the lesion area is found to the greatest extent from the decision factors of transform. Experiments in this paper show that under the same circumstances, the model for identification of pneumonia in CXR based on the transformer backbone network has higher accuracy than that based on the traditional convolutional neural backbone network. e image enhancement scheme for CXR in this model will play a positive role in improving the accuracy rate of the model. rough the research in this paper, the bottleneck problem of improving the accuracy of the model for identification of pneumonia in CXR based on the traditional convolutional neural network can be overcome, and better results can be achieved. To sum up, the research in this paper has its value both theoretically and practically in the identification of pneumonia and even more diseases in CXR.

Proposed Scheme
In order to better compare the difference between the model for identification of pneumonia in CXR based on transformer backbone network and the models based on traditional convolutional neural backbone network, the experiment in this paper was done on the Chest X-ray data set [9] and CXR images (pneumonia) data set [21], because a large number of scholars used these data sets when testing the models based on the traditional convolutional neural backbone network. It should be noted that the former data set comes from the National Institutes of health, and the latter data set comes from Guangzhou Women and Children's Medical Center, and these data sets are publicly available for free use in scientific research. e chest X-ray data set is a data set of more than 100000 anonymous chest X-ray images released by the National Institutes of health to the scientific community. e copyright of this data set is announced on https://www.nih.gov/ news-events/news-releases/nih-clinical-center-providesone-largest-publicly-available-chest-x-ray-datasets-scientificcommunity, " e release will allow researchers across the country and around the world to freely access the datasets and increase their ability to teach computers how to detect and diagnose disease." e number of samples in the Chest X-ray data set [9] is shown in Table 1.
In the CXR images (pneumonia) data set [21], there are 5,856 anonymous chest X-ray images from Guangzhou Women and Children's Medical Center with "license CC BY 4.0". e text of the CC BY 4.0 was retrieved from https:// creativecommons.org/licenses/by/4.0/, and for more information, view the full license text at https://creativecommons. org/licenses/by/4.0/legalcode. is data set is divided into two categories: pneumonia and normal. e number of samples in the CXR images (pneumonia) data set is shown in Table 2.
e model used in the experiment in this paper is based on the Swin Transformer backbone network [22] and optimizes the CXR accordingly. e basic steps are as follows ( Figure 1): in addition to the obvious feature of a gray-scale image, CXR generally has its own characteristics such as low brightness, poor contrast, and high noise, so the first step is to improve the brightness, contrast, and suppress noise of the image according to the features of CXR. e second step is to obtain the best parameters of the model, the images are divided into a training set and validation set, normalize the images in the training set, and after random scaling, clipping, and flipping send them to the transformer network and fully connected network for training to obtain the best parameters of this model. e purpose of normalizing images is to facilitate the speedy contingency of the network. e purpose of random scaling, clipping, and flipping is to make the model not "see" the same image twice during training, so it has better generalization ability. A transformer network is used for feature extraction and a fully connected network is used for classification. In the third step, the images in the validation set are scaled and sent to the transformer network with trained parameters for feature extraction, and then send to the fully connected network with trained parameters for classification. e fourth step is to extract the decision factor from the Transformer network. e last step is to map the decision factor to the original image to output the lesion area.
e first was to do experiments with the model in this paper on the Chest X-ray data set, and then the experimental results are compared with the experimental results of models based on AlexNet [3], GoogLeNet [4], VGGNet16 [5], and ResNet50 [6] from the Wang's team on the same data set, the experimental results of model based on DenseNet [8] from Yao and other scholars, and the experimental results of model based on DenseNet121 [8] from Rajpurkar et al. In order to verify the effectiveness of image enhancement according to the features of CXR, a comparison experiment between enhanced and nonenhanced images in the preprocessing with the model based on the Transformer backbone network was carried out, and the two experimental results were compared. As shown in Figure 2, it is a contrast map for CXR enhancement, in which the left side is before enhancement, and the right side is after enhancement.
In order to further verify the versatility of this model for the identification of pneumonia in CXR based on the transformer backbone network, a comparative experiment on the CXR Images (Pneumonia) dataset [21] was carried out and compared its result with the experimental results of other models on the same dataset.
Finally, in the experiment, the decision factors of the identification in the chest X-ray image from the Swin transformer were extracted, and with the Grad-CAM [23] they were superimposed on the original image to perform the discriminative output of the lesion area.

Experimental Result
e accuracy of the experiment results with the model in this paper on the Chest X-ray data set reached 87.3%. From the comparison in Table 3, it can be seen that the model based on the Swin Transformer backbone network and optimized for CXR is obviously better than other models based on traditional convolutional neural network.
In the experiment to verify the effectiveness of preprocessing of image enhancement according to the features of CXR, this paper collects the accuracy data of the model based on the Swin Transformer backbone network during the training process. As shown in Figure 3, in order to show the details more clearly, the figure draws a line graph of the accuracy from batches 32 to 128 on the first epoch without image enhancement and with image enhancement, in which the blue dotted line is no enhancement, and the orange  International Journal of Antennas and Propagation dashed line is enhancement. As can be seen from Figure 3, the accuracy of image enhancement according to the features of CXR will be higher than that without image enhancement under the same circumstances.
In the comparative experiment on the CXR Images (Pneumonia) data set, the model based on the Swin Transformer backbone network and optimized for CXR in this paper achieved the best accuracy of 97.2% after only five epochs of training, which is much higher than the accuracy rate of 92.8% from the model based on the convolutional neural network proposed by Kermany's team [13]. It is also higher than the competition results in the Kaggle on the CXR Images (Pneumonia) data set (https://www.kaggle. com/datasets/paultimothymooney/chest-xray-pneumonia/ discussion/). e comparison data of accuracy from different models are shown in Table 4.
In Figures 4 and 5, the cross-entropy loss and accuracy during the training process using the model in this paper are shown. e top figure shows the change of the cross-entropy loss on epochs (the blue dotted line is from the data of the training set, and the orange dashed line is from the data of the validation set), and the bottom figure shows the change of the accuracy on epochs (the blue dotted line is from data of the training set, and the orange dashed line is from the data of the validation set).
What is the reason for the higher accuracy on the validation set than on the corresponding training set ( Figure 5)? Because in order to enhance the generalization ability of the model, the data of the training set are randomly scaled, cropped, and flipped before entering the transformer network to extract features, while the data of the validation set has not undergone this transformation.
Before the transformation of the Softmax function and entering the fully connected classification network, the decision factors of the identification in chest X-ray image from the transformer are extracted. In our experiments, the decision factors are from the norm layer following the transformer backbone network, which can be obtained by back-propagating the result value of the latter classification network. e reverse derivation according to the Grad-CAM  Backbone network Validate-accuracy (%) Wang, et al. [9] AlexNet 54.9 Wang et al. [9] GoogLeNet 59.9 Wang et al. [9] VGGNet-16 51.0 Wang et al. [9] ResNet-50 63.3 Yao et al. [10] DenseNet 71.3 Rajpurkar et al. [11] DenseNet-121 76.3 is paper SwinTransformer 87.3

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algorithm is superimposed with the original image to form a heat map as shown in Figure 6. e area with high color temperature is the area that plays an important role in the formation of network discrimination, so the corresponding lesion area can be obtained.

Discussion and Analysis
After several years of research, the research of the application models based on the traditional convolutional neural backbone networks such as AlexNet, VGGNet, GoogLeNet, ResNet, DenseNet, and E cientNet has gradually entered the bottleneck period of network performance improvement, and the improvement e ect in the application models research of CXR also gradually becomes less obvious. At this time, a new backbone network is urgently needed to solve this problem. Vaswani et al. from the Google team proposed the transformer backbone network in 2017 [24]. Compared with the traditional Recurrent Neural Network [25], Transformer has many advantages such as in nite memory length in theory and parallel operation. e theory of the selfattention algorithm is the basis of the transformer (1).
In transformer multihead, self-attention extended from the self-attention algorithm is used, and it is split by linear mapping according to the number of headers and is usually divided equally (2).
e transformer was originally used for natural language processing. At the 2020 International Conference on Computer Vision and Pattern Recognition (CVPR), the

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Google team proposed a scheme to apply transformers to the eld of computer vision and achieved good results [26]. e core of the transformer comes from the self-attention algorithm, and the self-attention algorithm and the convolution algorithm are very closely related, and the latter can be considered as a subset of the former [27]. As the scale of the data set increases, the performance of the transformer backbone network will exceed the traditional convolutional neural backbone networks, and large-scale training data can encourage the transformer to learn the more translation equivariance and locality than possessed by the convolutional neural networks. In 2021, the Swin Transformer proposed by Microsoft Research Asia has become a bright spot. It overcomes the bottleneck of the traditional convolutional neural backbone network to a certain extent and further improves the accuracy [22]. e experimental comparison results [22] of its e ect on the ImageNet-1K data set are as follows shown in Table 5. e di erence from convolutional neural networks such as ResNet is that the Swin Transformer no longer uses traditional convolution kernels in feature extraction, and the core at each level is window multihead self-attention and shifted window multihead self-attention. Window multihead self-attention is the multihead self-attention matrix operation performed inside the window. e advantage is to reduce the amount of computation, but the disadvantage is that information interaction between windows is not possible. e shifted window multihead self-attention is designed to overcome this shortcoming, and it can realize the information interaction between di erent windows by shifting the window position.
Since the Swin transformer backbone network has not been proposed for a long time, its application in various elds has not been su ciently studied, and few studies have been conducted to optimize the model for the application of CXR images. Regarding the application model in the CXR eld, the model proposed in this paper is no longer based on the traditional convolutional neural backbone network, but the Swin transformer backbone network is introduced to build the model. e experimental results on the two CXR data sets prove that the accuracy of the model based on the transformer backbone network is higher than that of the model based on the traditional convolutional neural backbone network model on the same data set, and the e ect is improved obviously, which can overcome the existing bottleneck of improving the accuracy of model based on the convolutional neural backbone network.
It is necessary to highlight image details and suppress noise because CXR is usually characterized by low brightness, low contrast, and large noise. In the histogram of CXR, the area with the highest pixel distribution is usually the background, which is a nonconcern area, so this part can be peaked. If the values in the histogram are evenly distributed, it means that the distribution on each gray level is balanced, and the contrast is the best at this time, that is, the image is generally clear. erefore, a certain degree of equalization processing on each gray level in the histogram of CXR is helpful to the subsequent processing. It can be seen from the data chart of the experimental results ( Figure 3) that this processing method is e ective for the model based on the transformer backbone network. e concept of class activation mapping (CAM) originated from the interpretability research of deep neural networks [28] and was later introduced into application research by some scholars. On this basis, Selvaraju et al. proposed gradient weighted activation mapping (Grad-CAM) [29].
In the experiment of CXR in this paper, gradient weighted activation mapping is combined into the transformer, so that by extracting the decision factors of the identi cation in CXR from the transformer, the heat map through reverse derivation is superimposed on the original    [30]. In similar cases, it is estimated that the model with the Transformer backbone network will be better.

Conclusion
Pneumonia is a disease with a high mortality rate. Chest X-ray imaging is widely used in the routine examination of pneumonia. CXR as an important adjunct to the diagnosis of pneumonia can diagnose pneumonia quickly and accurately. Machine learning methods based on deep learning have been effective in chest X-ray imaging. In this paper, the Swin Transformer is applied to the application model of CXR image recognition and analysis, and the model is optimized accordingly according to the characteristics of CXR. e experimental results show that the model outperforms the model based on the traditional convolutional neural backbone network.

Data Availability
e data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest
e authors declare that there are no conflicts of interest regarding the publication of this paper.