Efficacy of CAD/CAM Glass Fiber Posts for the Restoration of Endodontically Treated Teeth

Objective The aim of this systematic review was to provide an overview of available scientific evidence regarding the comparative efficacy of computer-aided design (CAD) and computer-aided manufacturing (CAM) glass fiber posts with prefabricated and metal cast posts for the restoration of endodontically treated teeth (ETT). Methods This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Electronic and manual searches were performed using the PubMed, SciELO, Cochrane, ScienceDirect, Web of Science, and EBSCO databases. The reference lists of the selected papers were reviewed to identify relevant papers. There were no year restrictions, and eligible studies were those in English publications and describing in vitro studies evaluating intraradicular retainers (IRs) for (i) fracture resistance, (ii) bond strength, (iii) adaptation, and (iv) cement layer thickness. Literature reviews, systematic reviews, meta-analyses, case reports, in vitro studies with <8 specimens, and noncomparative trials involving prefabricated or metal cast posts were excluded. The authors of this review independently screened the search results, extracted data, and assessed the risk of bias. Results No significant differences were found in fracture resistance between prefabricated and CAD/CAM glass fiber posts or between CAD/CAM glass fiber and metal cast posts, although the latter demonstrated higher fracture resistance than the prefabricated glass fiber posts. Restoration with a full crown was not necessary to increase the fracture resistance in the presence of the ferrule effect. CAD/CAM glass fiber and metal cast posts had higher bond strength, lower nanoleakage, and better adaptation to the root canal. Conclusions Despite the heterogeneity of methodologies and results reported, the results of these studies indicated that the CAD/CAM glass fiber and metal cast posts showed greater efficacy in terms of fracture resistance, retention, and adaptation, compared to prefabricated glass fiber posts.


Introduction
e restoration of endodontically treated teeth (ETT) represents a critical problem in restorative dentistry, in which it may be necessary to use intraradicular retainers (IRs) to successfully perform a prosthetic restoration, depending on the specific conditions of the clinical case [1]. ere are types of IRs, including fiber-reinforced composite posts, which provide rigidity and resistance to an elastic matrix. Glass fiber posts have a low elastic modulus (40 GPa) compared to other IRs, such as carbon fiber posts (75-215 GPa) and gold cast posts (85 GPa). In IRs with lower elastic moduli, the tooth, cement, and IR undergo deformation at the weakest point, the IR-luting cement-dentin interface, during occlusal function. is in turn causes loss of marginal seal, fracture of the IR or the root, and/or loss of retention [2]. In the most rigid IRs, the forces are distributed along the root, leading to fatigue failure and the possibility of a catastrophic or irrepairable fracture [2]. For this reason, it has been suggested that the materials used to restore an ETT should have physical and mechanical properties similar to those of dentin [3].
Previous studies have stated that glass fiber posts have biomechanical properties similar to those of dentin [4][5][6], with favorable elastic moduli, fracture resistance, and bond strength, depending on the reinforcement used in the system, and also present optimal esthetic advantages for prosthetic restorations [7]. However, one of the main disadvantages of glass fiber posts is the industrial prefabrication process. Due to the variety of commercial presentations, post diameters have been standardized and may not adequately fit the root canal lumen. is in turn requires further preparation of the canal for the post placement or opting to use a smaller diameter post [8]. Balkenhol et al. [9] determined that the survival rate of posts is primarily related to the adaptation of the post to the anatomy of the root canal, which is a variable of greater relevance than the luting agent itself [10].
With recent advances in technology such as computeraided design (CAD) and computer-aided manufacturing (CAM), new processes for the manufacture of dental restorations have allowed for the development of a new technique for creating IRs, by creating a digital working model, which allows the scanning, designing, and milling of IRs. Additionally, de Moraes et al. [11] established that the use of CAD/CAM technology eliminates the need to use materials susceptible to dimensional changes. A recent study suggested the use of glass fiber-reinforced polymeric (GFRP) composite blocks for CAD/CAM posts [12]; however, little evidence is available on the efficacy of these compared to conventional IRs such as prefabricated glass fiber and metal cast posts.
Given the multitude of options available, the objective of this systematic review was to provide an overview of the available scientific evidence on the efficacy of CAD/CAM glass fiber posts for the restoration of ETT compared to prefabricated and metal cast posts. In this study, "efficacy" is defined as behavior related to fracture resistance, bond strength, adaptation of the post to the root canal walls, and the thickness of cement layer.

Methods
is systematic review was carried out according to the parameters defined by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines [13]. Based on the population of the study, intervention, comparison, and outcome, the research question was raised, as follows: How effective are CAD/CAM fiberglass posts for ETT restoration compared to prefabricated and metal cast posts? e study was recorded in the database of the International Prospective Registry of Systematic Reviews (Prospero), as number CRD42020215690.

Eligibility Criteria.
e criteria for inclusion in the present study were as follows: (1) studies regarding in vitro quantitative experiments that evaluated the biomechanical behaviors of IRs, taking into account fracture resistance, post-dentin bond strength, and adaptation of the post to the root canal walls; (2) studies that included samples of human or bovine teeth restored with IRs or those that directly evaluated the materials used in IRs; (3) studies that examined the mechanical properties of IRs through push-or pullout tests, flexural strength, and/or tensile strength; and (4) studies that microscopically evaluated the adaptation and interfacial nanoleakage of IRs. Literature review studies, systematic reviews, meta-analyses, and case reports were excluded. In vitro studies with a sample size <8 specimens were excluded, as were the trials that did not carry out comparative studies including prefabricated or metal cast posts.

Outcomes of Interest.
e outcomes of interest in this study were (1) the behavior of the IRs with regard to fracture resistance, (2) the post-cement-dentin bond strength, (3) the adaptation of the post to the root canal walls, and (4) the thickness of the cement layer, specifically comparing glass fiber posts made using a CAD/CAM technique with prefabricated posts and metal cast posts.

Data Sources and Search
Strategy. An electronic search was performed using the following databases: PubMed, SciELO, Cochrane, ScienceDirect, Web of Science, EBSCO, and Latin-American and Caribbean System on Health Science Information (LILACS). Additionally, a manual search was performed, in which the reference lists of the included articles were reviewed according to the eligibility criteria. Studies in English and Spanish were selected, there were no restrictions on the year of publication, and the most recent search was performed on February 9, 2021. Keywords and MeSH terms were used, such as "CAD/CAM," "fiber posts," "flexural strength," "fracture resistance," and "bond strength." Algorithms were used for the search strategy of this study (Table 1).

Methods of Evaluation and Synthesis of the Included Studies.
To assess whether the studies met the inclusion criteria, two authors (C. G. and M. G.) reviewed the titles and abstracts of the articles. Subsequently, based on the inclusion criteria, the abstracts were rereviewed independently by another author (P. B.) to reach a consensus. Next, full-text articles were obtained and reviewed by two authors (C. G. and M. G.), and the final decision was made in consensus with the last author (P. B.). Any disagreement was discussed between the authors (C. G., P. B., and M. G.). e reference lists of the selected articles were then reviewed to verify if there were eligible articles that had been excluded from the electronic search. Finally, full texts of the included studies were evaluated. A protocol for data extraction (PRISMA) was implemented, and the data related to the research question were extracted and recorded in duplicate, using forms designed for this purpose, taking into account (1) citation: location of the study and year of publication, (2) type of study, (3) characteristics of the samples, (4) type of interventions, (5) results obtained, (6) conclusions, and (7) source of financing and conflicts of interest. e data obtained regarding the posts were analyzed, based on the handling of the samples, for (1) fracture resistance, (2) bond strength, (3) adaptation, and (4) cement layer thickness.

Assessment of Risk of Bias and Quality of Included Studies.
e methodological quality of the included studies was evaluated as previously described by Sarkis-Onofre et al. [14] and according to the Checklist for Reporting In vitro Studies (CRIS Guidelines) [15]. To assess the quality and risk of bias of the included studies, the following were taken into account: whether or not the allocation of teeth was randomized, whether or not the teeth used were free of caries or restorations, the use of the materials based on the manufacturer's instructions, whether or not the procedures were performed by the same operator, if there was a description of the calculation of the sample size, and the blinding of the test machine operator. e risk of bias for each study was determined by totaling the number of parameters reported, rated as either yes (Y) or no (N). Studies that reported 1-2 parameters were classified as having a high risk of bias, 3-4 as having a medium risk, and 5-6 as having a low risk.
2.6. Data Analysis. Data extracted from the included fulltext articles were recorded in an evidence table. Variables common to the different articles were identified to facilitate the consolidation of the data from the collection, specimen, sample storage, handling, and processing of the samples, as well as the evaluation techniques and values obtained. ese included fracture resistance measured in Newtons (N), bond strength in megapascals (MPa), adaptation of the post to the root canal walls according to the presence of nanoleakage, and the thickness of the cement layer in micrometers (μm), found in the different test groups.

Search Results.
Initially, 53 studies were identified from the different databases, 27 of which were selected after eliminating duplicate reports. Of the 27 studies, 19 were excluded based on title and abstract; therefore, 8 studies were selected for full-text reading, 1 of which was excluded based on the eligibility criteria. e article by Ruschel et al. [16] was excluded because their study included <8 specimens (Figure 1). In total, 7 articles were included in this systematic review ( Table 2).

Risk of Bias and Quality Assessment.
e risk of bias of the seven included studies was analyzed, and none of which presented a low risk, while five [17,19,[21][22][23] presented a moderate risk (71.4%), and two (18,20) were classified as high risk (28.5%). e bias evaluation was performed according to the parameters listed in Table 3.

Data Analysis and Treatment Effects.
e results of the included studies are listed in Table 4 and the comparative efficacy according to the properties studied is analyzed in Table 5. e differences in the methodologies, as shown in Table 2, with respect to the type of tooth, the storage of the samples, the cuts for the laboratory tests, the simulation of the periodontal ligament, the presence or absence of a crown as a final restoration, the instrumentation technique for the filling of the canals, the cementing agent used for the cementation of the IRs, and variations in the characteristics of the laboratory tests evaluated (treatment of the samples, direction of load, surface area of load, crosshead speed, and aging of the samples) showed heterogeneous results, for which only one individual analysis of each in vitro study was performed.

Study Location.
e characteristics of the included studies are summarized in Table 2. Of the included studies, one was carried out in China [17], three were carried out in  Records not retrieved (n = 0) Reason 1 (n = 1) sample less than 8 specimens: Ruschel et al. [16] Identification of studies via databases and registers Identification Screening Included Records screened (n = 27) Reports sought for retrieval (n = 0) Reports assessed for eligibility (n = 8) Studies included in review (n = 7) Reports of included studies (n = 7) Reports excluded:       e one-piece post and core can be successfully milled from FRR blocks and high-density polymer material discs using CAD/CAM technology. High-density polymer CAD/CAM GFP * showed a better performance than prefabricated fiber posts. 6 International Journal of Biomaterials Lebanon [19,22,23], two in Brazil [20,21], and one was carried out in Italy [18]. Six were conducted in universities [18][19][20][21][22][23] and one was conducted in a hospital [17]. Only one study was funded by a foundation [20], and two studies reported no funding [19,22]. Two studies received materials for the execution of the research through dental companies [20,21], and all studies were published as full text.

Specimens.
Human teeth were used in all studies [17][18][19][20][21][22][23], five of which used premolars [18-20, 22, 23], one used incisors [17], and one used canine teeth [21]. e sample size was established according to the number of teeth per group of each material to be evaluated. For the studies that evaluated the bond strength (push-out test) [18,22,23] and nanoleakage [18], micro samples of 1 mm thick sections  CAD/CAM GFP * do not affect the fracture resistance of widened root canals or cause catastrophic root failure when the tooth is rehabilitated with zirconia crowns. [21] Fracture resistance/ fracture testing Failure mode/optical microscope N No statistically significant difference was found in fracture resistance under oblique loading in the case of hybrid CAD/CAM blocks and fiber posts were used, in both the ferrule and no-ferrule groups. e failure mode distribution of the group without ferrule effect did not present unfavorable failures, while the failures in the ferrule groups were distributed between the favorable and unfavorable groups.
Hybrid CAD/CAM blocks can be considered as an alternative restoration system for post and core restorations. More clinical and laboratory research needs to be done to support the improvement of this system. [22] Bond strength/pushout test Failure mode/stereo microscope

MPa
Bond strength was significantly lower in Group 3 (RXP) (8.54 ± 3.35 MPa) compared to Group 1 (CP) (12.10 ± 1.38 MPa), while no significant differences were found between the other groups. e failure was mainly adhesive for Groups 2 and 3 and adhesive and mixed for Group 1. e use of CAD/CAM custom FRRP * has a positive effect on bond strength to root canal walls compared to prefabricated GFP * . Self-adhesive resin cements to radicular dentin did not significantly improve the bond strength of prefabricated posts, where friction appears to play a predominant role in post retention. International Journal of Biomaterials were used, and one study used 0.01 mm thick sections to measure the thickness of the cement layer [20].

Storage Protocols.
e postextraction teeth used in the tests were stored in different substances. Four studies used 0.5% chloramine T [19,20,22,23], one used water [18], and two did not report the substance used [17,21]. e storage time of the teeth from extraction to testing ranged from one week to six months. ree studies stored teeth at a temperature of 37°C [18,20,21], while the other four studies did not report the storage temperature [17,19,22,23].

Sample Characteristics and Root Canal Preparation
Protocols. e samples used in the seven studies reported a root length of 12-15 mm. Any crowns were removed using a rotary cutting instrument with refrigeration, with the amelocemental junction as a reference. One study used a ferrule effect with a 2 mm cut over the amelocemental junction [21]; one study performed this cut at 1 mm [17], and another at 1.5 mm [19]. One study divided the samples into groups with and without a ferrule effect [21], and two studies did not report having performed a coronal cut [22,23]. Only two studies performed a simulation of the periodontal ligament to assess fracture resistance [17,21], and five studies did not report such simulations [18-20, 22, 23].

Adaptation Techniques of Intraradicular Posts.
Pang et al. [17] tested the adaptation of prefabricated glass fiber posts with an indicator to eliminate the blocking points and subsequently performed a sandblasting treatment with alumina. Otherwise, for the metal cast posts, in the work of Tsintsadze et al. [18], the pattern was made with a self-curing acrylic pattern resin (GC, Tokyo, Japan), which was carefully observed by the operator to identify imperfections or bubbles in the material in order to guarantee the adaptation after the casting process. Tsintsadze et al. [18] and Passos et al. [21] evaluated the fit of CAD/CAM glass fiber posts by using polyvinyl siloxane outside the posts. Additionally, Passos et al. [21] polished the surface of the post with finishing and polishing discs (Sof-Lex, 3M ESPE, St. Paul, MN, USA). is technique was repeated until adequate positioning was achieved. Eid et al. [22,23] reported that CAD/CAM glass fiber posts were adapted in the root canals without the need for adjustments. Likewise, da Costa et al. [20] adjusted the posts for seating with an abrasive bur (Exa-Cerapol, Edenta AG, Heidelberg, Switzerland), while Eid et al. [19] did not report the process for adapting the post to the root canal.

Cementation of Intraradicular Retainers.
For the cementation of the IRs, universal self-adhesive cement was used in five studies [17,19,[21][22][23], while in one study dual curing cement was used [18], and one study did not report the cementing agent used [20].    [17] and Passos et al. [21], used a 45°loading direction. da Costa et al. [20] performed a cyclical load to generate fatigue (parallel to the longitudinal axis of the tooth) before the oblique compression test (load direction at 30°until failure). According to the crosshead speed, three studies used a speed of 1 mm/min to apply the load [17,19,20], and only one study [21] used a speed of 0.5 mm/min until failure. e reported cycles of the fatigue tests were 300,000 cycles [17] and 1,000,000 cycles [20].
(2) Bond Strength. ree studies evaluated the bond strength through push-out tests, measured in megapascals (MPa) [18,22,23]. ese studies applied the tensile load in the apicocoronal direction in each cut made (1 mm thick sections from the cervical, middle, and apical thirds), placing cylindrical emboli in the center of the posts of each section until failure occurred (extrusion of the section post segment). Two studies [22,23] performed aging samples employing thermocycling, from 5,000 to 6,000 cycles.
(3) Interfacial Nanoleakage. Tsintsadze et al. [18] evaluated the presence of nanoleakages using silver nitrate as a tracer. For the treatment of the samples, the samples were covered with nail varnish, except for the post-dentin-cement interface. ey were then observed under a light microscope at 40X magnification for tracer filtration along with the interface (scored from 0 to 4).
(4) Cement Layer ickness. Tsintsadze et al. [18] analyzed six sections (1 mm thick) from each root using a digital microscope to determine the thickness (in μm) of the cement surrounding the posts. da Costa et al. [20] used micro-CT in two specimens from each group (CAD/CAM glass fiber posts and prefabricated glass fiber posts without crowns) using 0.01 mm thick cross sections of the root.

Evaluation of the Efficacy
Of the included studies, four evaluated the fracture resistance of the IRs [17,[19][20][21]. e most relevant results did not show significant differences in the performance of prefabricated glass fiber and CAD/CAM glass fiber posts [19][20][21]. No statistically significant differences were found in the fracture resistance of CAD/CAM glass fiber posts and gold cast posts (p > 0.05). However, higher fracture resistance values were observed for both materials compared to prefabricated glass fiber posts (p < 0.05) [17]. Additionally, the presence of a crown was a determining factor for the fracture resistance of prefabricated glass fiber and CAD/CAM glass fiber posts [20]. Passos et al. [21] did not report any statistically significant differences in the fracture resistance between CAD/CAM glass fiber and prefabricated glass fiber posts, both with and without ferrule (p > 0.05). Nevertheless, statistically significant differences were found between samples composed of the same material (CAD/CAM glass fiber post with and without ferrule and prefabricated glass fiber posts with and without ferrule), with increased fracture resistance observed in the samples with ferrule (p < 0.05).

Post-Cement-Dentin Bond Strength.
Of the studies included, three evaluated the bond strength of IRs [18,22,23]. e studies by Eid et al. [22,23] showed a higher bond strength with CAD/CAM glass fiber posts compared to that obtained with prefabricated glass fiber posts (p < 0.001). Similar results were reported by Tsintsadze et al. [18], who found that the group of CAD/CAM glass fiber posts and metal cast posts (base metal alloy Keramit NP, Nobil Metal, Asti, Italy) showed similar bond strength values, which were higher than the bond strength values of the group of prefabricated glass fiber posts. ey reported that the post material influenced the bond strength (p < 0.05). Eid et al. [22] used petroleum jelly as a lubricant on CAD/CAM glass fiber posts before cementation, which did not affect the bond strength of the metal cast posts.
Tsintsadze et al. [18] reported no differences in the values of bond strength in each root third. In contrast, Eid et al. [23] established that there was a statistically significant difference between the different parts of the root in the CAD/CAM glass (p � 0.026), CAD/CAM high-density polymer (p � 0.002), and fiber-reinforced composite (FRC) prefabricated posts (p � 0.023), since the CAD/CAM glass fiber showed a higher bond strength in the coronal third compared to the middle third (p � 0.024); meanwhile, with the prefabricated FRC posts, lower values were observed in the coronal third than in the apical third (p � 0.023). Eid et al. [23] found no influence of thermal aging of the samples on the bond strength values in any of the groups (p � 0.536).

Adapting the Post to the Root Canal Walls.
Tsintsadze et al. [18] evaluated the internal adaptation of IRs by employing an interfacial nanoleakage test. Statistical analysis showed that the lowest score was observed in the base metal alloy cast posts, compared to CAD/CAM glass fiber and prefabricated glass fiber posts. However, the latter two groups showed similar values.

ickness of Cement Layer.
e studies by Tsintsadze et al. [18] and da Costa et al. [20] showed a statistically significant difference in cement thickness based on the type of post and the root thirds evaluated. Tsintsadze et al. [18] reported that the lowest cement thickness was found in the metal cast posts, followed by CAD/CAM posts, and finally by prefabricated glass fiber posts. Similar results were reported by da Costa et al. [20], who found a greater luting agent thickness in prefabricated glass fiber posts compared to CAD/CAM glass fiber posts. According to the category of voids present in the cement film, CAD/CAM glass fiber posts had a higher percentage (80%) of cases in which voids were absent in all root thirds.

Discussion
is systematic review aimed to compile and analyze the available scientific evidence regarding the efficacy of glass fiber posts made using CAD/CAM techniques compared to prefabricated posts and metal cast posts.

Summary of Main Results.
No statistically significant differences were observed in IR fracture resistance between prefabricated glass fiber and CAD/CAM glass fiber posts [19][20][21]. Similarly, there was no evidence of a difference between the fracture resistances of the CAD/CAM glass fiber and the metal cast posts; however, the latter demonstrated a better fracture resistance than prefabricated glass fiber posts [17]. e presence of a crown was not a determining factor for fracture resistance [20], but the presence of a ferrule increased fracture resistance [21]. With respect to the postcement-dentin bond strength, the IR material was found to influence bonding values [18]. Prefabricated glass fiber posts have lower bond strength than CAD/CAM glass fiber posts [18,22,23] and metal cast posts [18]. Additionally, CAD/ CAM glass fiber posts showed greater bond strength in the coronal than in the middle third, while the prefabricated FRC posts showed a lower bond strength in the coronal than in the apical third. e influence of thermal aging on bond strength values was not observed [23]. e metal cast posts demonstrated better internal adaptation than CAD/CAM glass fiber and prefabricated glass fiber posts, which demonstrated a more significant mismatch to the root canal walls [18].

Quality of the Evidence, Limitations, and Possible Biases in the Review.
e results of the studies included in the present review correspond to in vitro studies, which must be interpreted with caution, since they cannot wholly reflect all circumstances of a clinical situation. Additionally, the differences in the type of tooth, storage of the samples, instrumentation techniques for the sealing and desobturation of root canals, cement agent, shape of the root cuts for the laboratory tests, and variations of the characteristics of the laboratory tests (treatment of samples, type of load applied, cross-sectional area, crosshead speed, and aging samples) led to heterogeneous results, whereby only an individual analysis of the studies was conducted. According to the bias evaluation, none of the studies showed a low risk of bias (Table 3), which corresponds to a 100% risk of medium and high bias (Table 3).

Agreements and Disagreements with Other Studies or
Reviews.
e results of the studies included in the present review showed that the biomechanical behaviors of the different types of IRs are controversial, since some authors [19][20][21] found no significant differences in fracture resistance between the two types of posts and metal cast posts [19][20][21]. However, in contrast to these results, Pang et al. [17] reported that the CAD/CAM glass fiber posts and metal cast posts showed higher fracture resistance when compared to prefabricated glass fiber posts [17]. In contrast, Torres et al. [24] established that glass fiber posts increased ETT fracture resistance compared to gold cast posts, suggesting that multiple additional factors influence the biomechanical behaviors of the restored ETT with IRs.
An essential factor for the success of the restoration of the ETT is the material from which the IR is composed. Authors such as Falcão et al. [25] evaluated different materials for creating CAD/CAM IRs, such as nanoceramic resin composite post, Lava Ultimate (3M ESPE, St. Paul, MN, USA), and posts of hybrid ceramic, Vita Enamic (Vita, Bad Säckingen, Germany), which demonstrated good performance in terms of fracture resistance as a viable alternative to restore on oval-shaped roots and with esthetic commitment. According to Belli et al. [3], the elastic modulus of the material used for IRs influences the fracture resistance because a post and core with a high elastic modulus generate a greater concentration of stresses on the root dentin, resulting in an increased risk of fracture of the IR-tooth system. erefore, the preceding study suggested that a post and core system using a material with an elastic modulus similar to that of dentin should be implemented to ensure adequate stress dissipation and thus avoid areas of concentrated stress in the walls of the root that can generate failures at the post-cement-dentin interface or radicular fractures [3,26]. From this perspective, glass fiber systems have shown excellent biomechanical behavior compared to other materials [27]. e fibers have high tensile strength [28] and provide rigidity and resistance to a matrix that in turn is elastic; meanwhile, the metal cast post, being more rigid, transmits the stress directly to the remaining dental structure, leading to fatigue failures [2]. e above description becomes evident when analyzing the type of failure. Prefabricated glass fiber and gold cast posts were found to have catastrophic fractures in all cases, while CAD/CAM glass fiber posts presented repairable fractures in six cases and irrepairable fractures in four cases [17]. ese results agree with those reported by Figueiredo et al. [29], who found catastrophic failures in ETT restored with metal cast and glass fiber posts, with similar failure characteristics in both groups [29]. Additionally, Torres et al. [24] identified that the most frequent fracture site with gold cast posts was in the middle third (47.7%), which corresponds to a type of irrepairable failure, while the most frequent site with glass fiber posts was the cervical third (42.9%), which was thought to be a repairable fracture [24]. In contrast, Eid et al. [19] reported no catastrophic failures using prefabricated glass fiber, CAD/CAM glass fiber, or hybrid ceramic CAD/CAM posts [19]. e analysis of the differential behavior of the failure of the different IR systems is based on the biomechanical behavior of the structures that make up the system and the interfaces formed within. Regarding the failure analysis, Marchionatti et al. [30] concluded that failures of fiber posts were due to the loss of retention, while the metal cast posts showed fractures of the root or the post, as well as post decementation [30]. e above shows the number of possible types of failure in metal cast posts, rigid systems that generate a flexural deformation of the root under occlusal stresses, which do not produce a synchronous deformation of the metal cast post with the root tissue, thus creating concentrated stress zones that exceed the maximum stress values up to the point of ultimate strength where the fracture occurs [31]. e opposite is true of CAD/CAM glass fiber posts, which have an elastic modulus similar to dentin, meaning they adapt well to the root canal and optimize the resistance of the post and core system, suggesting that a CAD/CAM glass fiber post reduces the cement thickness at the bond interface and provides a better distribution of stress. erefore, both the bond strength and fracture resistance of the CAD/CAM glass fiber posts were higher than those of the other types of IRs [32].
Regarding the influence on the fracture resistance and the amount of coronal tissue remaining to generate a ferrule effect in ETT, Passos et al. [21] established that the presence of a ferrule increased the fracture resistance values in restorations made up of the same type of material [21]. is is in agreeance with the study by Marchionatti et al. [30], who concluded that the presence of dental remnants and the ferrule increased ETT survival [30] due to an increase in fracture resistance [33]. Additionally, it has been described that the ferrule effect allows a better distribution of stress towards the dental root [34].
Another crucial factor to consider is the change in the behavior of the fracture resistance of ETT when they are restored with a full crown. Catastrophic fractures were found in teeth restored with CAD/CAM glass fiber posts without a prosthetic crown [20], which may reinforce the restoration system by dissipating oblique stresses [35]. However, the results of da Costa et al. [20] showed that the presence or absence of a prosthetic crown does not influence fracture resistance [20], which highlights the importance of the conformation of the root portion more so than the coronal one in this type of restoration.
Regarding the post-cement-dentin bond strength, the adaptation of the IR to the canal anatomy influenced the bond strength values [18]. Studies have reported greater bond strength with CAD/CAM glass fiber posts than with prefabricated glass fiber posts, with which the thickness of the cement layer is increased [20,22] and adaptation to the root canal walls is decreased [18,22,23]. Additionally, the relationship of an adequate adaptation of the IR with lower nanoleakage [20] and an excellent stabilization of the bonding interface is evident. is interface can be affected by other factors such as moisture, the highly organic nature of the root dentin rich in dentinal tubules, the sensitivity of the bonding technique used, the type of cementing agent, the degree of conversion obtained [36], and polymerization shrinkage of resin cement [37]. Skupien et al. [38] reported that certain types of cementing agents, such as self-adhesive resin cement, are more sensitive to the technique used to perform cementation than conventional resin cement [38]. Advantages such as the presence of a thinner layer of cementing agent [39] which decreases the percentage of polymerization shrinkage [40] and the possibility of bubble and void formation can be definitive to increase the postcement-dentin bond strength [41]. e adaptation of CAD/ CAM fiber and cast posts plays a predominant role in the success of ETT.
Regarding the passive settlement of IRs into the root canal, Eid et al. [22] reported that CAD/CAM glass fiber posts have the advantage of seating without the need for adjustments. It is possible that establishing a detailed copy in the design software of the space required for the luting cement confers a precise adaptation of the posts to the canal [22,23]. Fransson et al. [42] considered an adaptation discrepancy of up to 150 μm acceptable [42,43]. Additionally, the standard of the International Organization for Standardization (ISO) 4049 of the year 2019 established an ideal cement layer thickness of 10-50 μm [44]. However, the studies included in the present review implemented an 80 μm cement thickness in the design software [22,23], based on the accepted discrepancy values in the literature.

Implications for Practice.
With the possible limitations of the present systematic review, taking into account the heterogeneity of methodologies and reported results, the analyses indicated that the CAD/CAM glass fiber posts had greater efficacy in terms of bond strength and post adaptation compared to prefabricated glass fiber posts and results similar to those of metal cast posts. However, it was evident that the biomechanical behaviors of the different types of IRs are still controversial because, for fracture resistance, in some studies, no significant differences were observed between the two types of posts and the metal cast post. However, other authors reported that CAD/CAM glass fiber and metal cast posts showed higher fracture resistance values when compared to prefabricated glass fiber posts. erefore, a comprehensive analysis of the multiple factors that can influence the biomechanical behaviors of IR-restored ETT is recommended.

Implications for Future Research.
Further investigations, such as in vivo studies, are needed to determine the efficacy of CAD/CAM glass fiber posts, since the currently available literature evaluated the biomechanical behaviors in in vitro studies, which, due to their experimental nature, do not allow an adequate correlation of the performance of the posts under clinical circumstances.

Conclusions
CAD/CAM posts demonstrated positive behaviors in terms of retention, fracture resistance, bond strength, and adaptation compared to the other types of IRs. Although longterm clinical trials are needed to corroborate the usefulness of this alternative, CAD/CAM glass fiber posts may be considered an effective alternative for ETT restoration.

Ethical Approval
is project was approved by the Ethics Committee of Facultad de Odontología, Universidad Nacional de Colombia (B.CIEFO-185-2020). is article does not contain any studies with human participants or animals performed by any of the authors.

Consent
For this type of study, formal consent is not required.

Conflicts of Interest
e authors do not have any financial interest in the companies whose materials are included in this article.