Clinical Conditions of Hospitalized Older Adult Patients and Their Outcomes in a Regional Referral Hospital in Southwestern Uganda

Background Recent advances in medicine have caused positive impact on the life expectancy of most countries, resulting in increased older adult population. Aging comes with a number of health challenges. This study investigated health conditions of older adults at admission and clinical outcomes in a regional referral hospital in southwestern Uganda. Methods A retrospective study reviewed clinical data of older adult patients admitted between January 2016 and December 2017. Demographic data, cause of admission, length, and outcomes of hospitalization are described. Results Up to 813 patient files were reviewed. The patients had been hospitalized to emergency, 371 (45.6%); medical, 355 (43.7%); surgical, 84 (10.3%); psychiatry, 2 (0.3%); and obstetrics and gynecology, 1 (0.1%) wards. The majority, 427 (52.5%), of the patients were females. Cancer was the most common reason for hospitalization, 130/889 (14.6%), followed by stroke, 94/889 (10.6%); heart failure, 76/889 (8.6%); chronic obstructive pulmonary disease, 56/889 (6.3%); pneumonia, 47/889 (5.3%); and head injury, 45/889 (5.1%), whilst 560 (68.9%) of the hospitalized patients were discharged, 197 (24.2%) died, 18 (2.2%) were referred for advanced care, and 38 (4.7%) escaped from the facility. The emergency ward had the highest deaths, 101 (51.3%), then medical, 56 (28.4%), and surgical, 39 (19.8%), wards. Mortality of those who died was admitted with stroke, 30 (15.2%), cancer, 21 (10.7%), head injury, 16 (8.1%), heart failure, 14 (7.1%), sepsis, 14 (7.1%), and renal disease, 12 (6.1%). On average, patients were admitted for 5 days (IQR: 3–8). Conclusions The high proportion of mortality in this group is worrying and requires further investigations.


Background
Globally, aging populations are emerging at a rapid rate due to the general increase in life expectancy following advance in medicine and improved health systems in most countries [1]. e United Nations Definition of Older Persons includes individuals aged 60 years and more [2].
In the 2016 WHO report, the global life expectancy was estimated at 72 years: 74.2 years for females and 69.8 years for males [3]. An annual growth of 3% has been noted among the older adult population [4], and many countries are expected to witness a similar trend over the years. In line with this, the global population of older adult people in 2017 was estimated to be 962 million people and projected to reach nearly 2.1 billion by 2050 [5], and the majority of whom (two-thirds) are in developing countries.
Old age comes with a number of medical and social challenges that need appropriate and timely interventions [5] to allow active participation in societal development. Indeed, studies have shown that older adult people contribute to up to 23% of the total global burden of diseases [6]. Also, more evidence particularly from developed countries indicate that older adult people are hospitalized more frequently and for a longer period of time than any other age groups as they tend to suffer more severe forms of diseases that are difficult to diagnose and treat [7,8]. is can be highly challenging in low resource settings as it continuously impacts on their psychological, social, economic abilities and that of the health system [9].
Even in developed countries where health services are much improved, challenges among older adult people are common. In one study, it has been reported that one-third of hospitalized older adult patients face more complication by the time of discharged, including reduced functional capacity, than at admission [10]. e study further reveals that approximately 5% of these die during hospital stay and 20%-30% pass away within one year after hospital discharge. is indicates that there is a much bigger hidden problem that needs to be urgently addressed in order to meet the WHO call for the Universal Health Coverage.
Although the WHO attributes most of the health problems of the older adults to chronic diseases [11], very few studies have investigated the specific type of conditions and extent of this burden in low resource countries. To properly address these concerns, it is important to study the common conditions so as to establish specific interventions.
Uganda is already experiencing an increase in the population of older adult people as a result of improved life expectancy to 62.5 years [12]. Indeed, in the 2017 WHO report, the older adult people constituted approximately 1425000 (3.3%) of general population and this number is expected to quadruple by 2050 [5]. Despite this increasing trend, most health facilities lack dedicated services for this particular population. Indeed, there is limited evidence on health conditions of hospitalized older adult patients in Uganda.
With accurate data on the profiles of older adult patients and the common diseases that cause their hospital admissions, policies can be enacted to adequately provide necessary human and infrastructural resources required to meet health needs of this age-group as emphasized in the holistic approach of the global agenda for sustainable development [5].
is study is among the fast to highlight the health plight of hospitalized older adult patients in a rural hospital in Uganda. e study also described the outcomes and common medical conditions that resulted in mortality among these patients.

Methods
We reviewed all medical records of older adult patients admitted between January 2016 and December 2018, on medical, psychiatry, obstetrics and gynecology, surgical, and emergency wards within Mbarara Regional Referral Hospital (MRRH) in southwestern Uganda. Demographic data, proportion of older adults, health reason, duration, and outcomes of hospitalization were described from the records. is was an exploratory study, and therefore sample size was not estimated. Instead, all the records within two years were judged to give reasonable evidence. As a quality control, each file was reviewed by two study research assistants and verified by the principal investigator.
Patient records were maintained at the strictest level of confidentiality by all members of the study team. On all data collection documents, patient identifiers such as names were concealed and replaced with unique study identification numbers and these records were maintained in locked file cabinets. e study was permitted by the MRRH administration and approved by the Research Ethics Committee of the Mbarara University of Science and Technology (18/08-18) as well as the Uganda National Council for Science and Technology (HS323ES).

Statistical Analysis
A case report form comprising of patient demographic data and clinical conditions was double entered into EpiData and analyzed using STATA version 13 (Texas, USA). Descriptive statistics were expressed as proportions in form of tables and graphs.

Discussion
is study investigated the health conditions that caused older adult people to be admitted at a regional hospital in a semiurban community of southwestern Uganda. e study highlights critical issues and eventual outcomes. According to our knowledge, this is the first study to bring attention to the heath plight of this particular population.
First, we have shown that close to 1000 older adult people were hospitalized in this regional hospital within two years. e male to female ratio was also close to 1, which is similar to what we observed in our previous tuberculosis study among adults aged 18 and above, in the same setting [13].
Secondly, our study has shown that cancer, stroke, heart failure, chronic obstructive disease, pneumonia, and head injury dominated as most common conditions causing hospitalization. e raise in the number of cancer cases in the country has been previously described in the general population [14]. e rates reported in this study are in tandem with national figures [12]. Other countries have reported a different disease spectrum in a similar population. In one of the few African studies, hypertension, heart failure, ischemic heart disease, and anemia were reported as the most predominant causes of hospitalization [15]. Besides diabetes, the main cause for hospitalization in Europe, the other main conditions include cardiovascular diseases and pulmonary diseases, which are similar to what we observed in this study [16]. Indeed, by grouping the health conditions observed, cardiovascular diseases such as stroke, heart failure, and hypertension together contributed up to 29.2% of disease burden. Another study reported these cardiovascular diseases (30.3%) as the leading contributors to disease burden in older adult people followed by cancer (15.1%) and chronic respiratory diseases (9·5%) [6]. Although different context, the proportions are much similar, indicating that addressing these health challenges could greatly minimize overall risks of hospitalization in many settings.
In the outcome analysis, this study observed an inhospital mortality rate of 24.2% while 68.9% were discharged. Our findings on mortality is much higher than 8.5%, 12%, 16.4%, and 14.9% previously reported in Turkey,   Portugal, Brazil, and Italy [16][17][18][19] in a similar population but close to what was observed in Nigeria (18.7%) within a related teaching hospital [20]. Again, our findings are the first to show such a high mortality in this population and require deeper investigations in future studies. We further investigated the most common health conditions that were observed among the patients that died during hospitalization. Stroke (15.2%), cancer (10.7%), head injury (8.1%), heart failure (7.1%), sepsis (7.1%), and renal disease (6.1%) accounted for the highest incidences. Indeed, the WHO predicts that by 2020, noncommunicable diseases such as heart disease, cancer, and diabetes will be among the main causes of mortality in the African region [21]. Already high incidences of cerebrovascular accident (25.1%) have been reported predominantly besides malignancies (15.2%), diabetes mellitus (8%), and congestive cardiac failure (6.2%) [20]. Others include septicemia (5.2%), trauma (4.6%), renal failure and chronic obstructive pulmonary disease (3.9%).
Currently, a joint extract from the WHO, World Bank, and UNESCO, reports HIV/AIDS (13.3%), pneumonia (11%), diarrheal diseases (6.4%), malaria (4.8%), and stroke (4.7%) among the most common causes of death in the general population in Uganda [12]. is is much different from what we observe in this study indicating that the two populations are completely unique. In addition, this adds more evidence to support the need for more attention in this age group.
According to the WHO, cancer is responsible for 365,000 deaths annually [22]. Because of that, the study tried to   investigate the types of cancer. We observed that oesophageal cancer, lung cancer, and prostate cancer accounted for the highest proportion. In the general public, the general national cancer mortality demographic data show that among males, prostate cancer (25.1%) is the most common cause of mortality followed by oesophagus cancer (16.0%) and liver cancer at 8.2%, while in females, it is cervical cancer (24.2%), breast cancer (12.5%), oesophageal cancer (7.7%), and liver cancer (5.8%) [22]. Our findings differ slightly from the national figure with oesophageal cancer being the most common cause of mortality. One of the limitations for this study is that some records did not provide sufficient demographic data. In addition, the antecedent causes of death were not confirmed due to paucity of postmortem reports. Finally, other outcomes that could impact the health systems such as hospital costs and readmission rate could not be explored.

Conclusion
Our study has highlighted the major health challenges that cause older adults to be hospitalized in a regional referral hospital population. In addition, the study has shown that there is poor prognosis in this age group and requires further comprehensive investigations.

Abbreviations
MRRH: Mbarara Regional Referral Hospital WHO: World Health Organization UNESCO: United Nations Educational, Scientific, and Cultural Organization.

Data Availability
e data used to support the findings of this study are available from the corresponding author upon request. Disclosure e content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.