Synthesis and Studies of Potential Antifungal and Antibacterial Agents New Aryl Thiazolyl Mercury ( II ) Derivatives Compounds

Combination of mercaptothiazoles and mercury phenyl chloride synthesized some new compounds of thiazoles. Firstly some mercaptothiazoles with different sorts have been synthesized, and then synthesized compounds were reacted with different mercury phenyl chloride structures. At last, each of these synthesized compounds was puri�ed. Conse�uently, these structures were recrystallized using oil ether. Forming product through chromatogram (TLC) and combination of Rff with other compound’s Rff of were identi�ed, and their purity percent was recognized.e H-NMR and other methods like FT-IR and mass spectroscopy have determined all of compounds.Obtained results of synthesized compounds showed that reactionswere carried outwith suitable speed and high yield.


Introduction
Having had various biological and pharmaceutical activities, chemistry of heterocyclic compounds such as thiazoles has been speci�cally noted and spread widely.ese compounds have shown different pharmaceutical and also antibacterial and antiviral activities; therefore they are of great remedial importance [1][2][3][4][5][6][7][8][9][10][11][12].In November 18th, 1887, molecular structure of thiazole was found and con�rmed by Hantzschet al.; they proved carbon existing between sulfur and nitrogen to be of high activity.e property led them to suggest pre�x �meso� for this situation.In 1889, the �rst thiazole derivative was obtained by Popp et al. ey provided 2amino thiazole structure by diazotation.ey are present in vitamin B1 [13] too.iazoles are such compounds applicable as antihyperglycemic [5].is property has caused these compounds to have abundant use in medicine and pharmaceutical industries as being used in antituberculosis medicine for instance [7].ey are also in insecticides and antivermin compounds related to agriculture.Due to having two different nitrogenous and sulfurous groups, the compounds tend to attend such different chemical reactions as alkylation, oxidation, and cycloaddition [8][9][10][11][12][13][14][15].High reactivity of the compounds has caused in many derivatives from them, which there are atoms of nitrogen, sulfur, and carbon being between them [16].As a ligand in complexometric reaction is another use they have [17].New compounds synthesis by some derivatives of phenacyl bromide, mercaptothiazole, and mercury (II) chloride is what being tried to be studied in present research.Of course it should be pointed out that these compound , s applicable and pharmaceutical properties can be studied in detail in future.FT-IR by a Perkin Elmer spectrum of 1420 spectrometer in the frequency range of 4000-400 cm −1 using KBr discs are was reported on 1 scale.e IR spectra were recorded at room temperature with the spectral resolution of 1 cm −1 .Used glossy instruments are as follows: roundbottom emery-top �asks with one or two ports species.Simple, bubble, and spiral radiator, Erlenmeyer �ask, beakers, three and two ports, links, addition funnel, Buchner funnel, capillary tube, and so forth.

Synthesis
Methods.iazoles and mercury phenyl chloride family separately were synthesized, and, consequently, many new kinds of aryl mercury (II) thiazolyl were obtained from these compounds.

2.2.1.
Preparation of Ammonium Dithiocarbamate.100.0 mL of ethanol 95% was poured in 250.0 mL of Erlenmeyer.It was kept in the ice bath, and then it was exposed to ammonia gas until weight increasing approximately 39.0 g was obtained.60.0 mL (1.0 mol) of carbon disul�de and 200.0 mL of diethyl ether were added to the solution, and it was kept for 2-3 hours in the ice container and then for 1 day in the refrigerator.Aer this time, yellow crystals of ammonium dithiocarbamate were formed.en content of container was strained and washed by ether (50.0 mL).80.0 g ammonium dithiocarbamate was produced.

Synthesis of Mercaptothiazole Derivatives Structure.
For synthesis of 4-(4 ′ -bromophenyl)-2-mercaptothiazole (3) in a 500 mL �ask 5.1 g of 4-bromophenacyl bromide was solved in ethanol.en 36.9 g ammonium dithiocarbamate was added and re�uxed for 3 hours.Distiller is used for reaction in constant pressure and control of free gases.Existing solvent by Rotary led to produced yellowish solid being re�uxed by 125.0 mL of benzenes for 15 minutes.en it was cooled for producing crystalline sediments; then it was rinsed and dried, the outcome of reaction was 18 g product with melting point of (218 ∘ C). e residue was puri�ed by thin-layer chromatography on silica gel (

Result and Discussion
For 6 new kinds of synthetic compounds of aryl thiazolyl mercury (II) �rstly, some compounds of Mercaptothiazoles were separately synthesized.Aer comparing   with other   , other compound identi�ed and using 1 H-NMR spectrometer, IR spectrometer and �nally mass spectrometer completed analyzing.For 6 synthetic compounds of thiazolyl mercury (II), the produce is shown in Figure 1.iazoles family had shown that substitution of hydrogen atom by methyl group was caused to the decrease of yield and sigma electron density in carbon atom of the cycle.But there is small increasing in electron density when hydrogen atom is substituted by sulfur atom.But quality of substitution mechanisms is different in thiazoles group.For example, substitution of methyl group in thiazoles structure is done by heteroatomic and hyperconjugation models.It is done by changing of pay electron.
Finally, aer analyzing the process and identifying considered compounds, 13 new compounds were recognized in which 6 of them were of thiazolyl mercury (II).Total process and obtained results are shown in Table 1 and Figures 2, 3,  and 4.
e reaction of 4-methoxy-phenyl mercury (II) chloride with 2-mercaptothiazoles leads to formation of 2-(4 ′′methoxy-phenyl mercury-thio-thiazoles). p-Anisidine is used as an initiator, then 4-methoxy-phenyl mercury (II) chloride is prepared with news Meyanov , s method.is was due to Diazo compound of p-anisidine and then reaction with HgCl and then reaction with copper powder; for the �rst reaction of 2-mercapto-4-(4′-methyl-phenyl) thiazole with 4-methoxy-phenyl mercury (II) chloride (with molar ratio of 1 : 1) in tetrahydrofuran (THF), then yellow wish crystal compound.In the NMR proton spectrum, have recognized the existence of all of signals of thiazoles part with substituent phenyl ring signals in the forth position.All of mentioned synthesis have followed from this method.We can explain this reaction in this way: because mercury is a so acid thus can conjugate easily with donor atoms in polarizable so bases.Mercury ion has great tendency for bounding with sulfur and the ligands containing sulfur atom.For above reasons, because of tendency bounding between mercury and sulfur in this research, we can bound two compounds of 4-(4 ′bromophenyl)-2-mercaptothiazole with p-methoxy mercury chloride molecular and p-bromomercury chloride.en consequently with exiting HCl we can obtain this bounding.For proving this theory such methods like TLC, 1 H-NMR, GC MASS, and IR are used in which all of them have recognized above claims.In this research, abundant usages of mercury in the dentistry and pharmacy and as a premier material of amalgam in dentistry that has repair usages.SCN bounds have biological and treatment properties, we have tried to investigate new ways and methods for synthesizing different thiazole derivatives.In this research, the physiological role of thiazolyl compounds has been examined and we have tried to synthesize some of its derivatives.e mechanism preparation 4-(4/-bromo-phenyl)-2-mercapto-thiazole with using p-bromoacetophenone and ammonium compounds and combination of ammonium dithiocarbamate in re�uxed with ethanol and then benzene, 4-(4 ′ -bromophenyl-2mercaptothiazole) was obtained.For making aromatic mercerized compound aromatic aniline (type I) was used.

Conclusions
Methods of aromatic system were used to increase speed of mechanism of separating and purifying of products does not need complex process.Production of these structures of thiazolyl mercury (II) through mention mechanism and producing HCl.Practically, these compounds have higher functions than the same synthetic compounds.