Preparation of α-Bromoketones Involving the Reaction of Enol Triethyl Borates with N-Bromosuccinimide

Bromination of ketones is an important reaction in synthetic organic chemistry [1] because bromoketones obtained this way are common intermediates in the synthesis of biologically active compounds. The bromination reaction constitutes the first step of introducing a heteroatom to generate stabilized carbanions [2] and support conjugation of the carbonyl group. In the classic procedures for α-bromination of ketones, hazardous molecular bromine is utilized [5–7]. Nbromosuccinimide (NBS) is a safer brominating reagent which can be used in milder reaction conditions. It has been reported that NBS brominates ketones in α position using radical initiators, such as azobisisobutyronitrile (AIBN) [8] or dibenzoyl peroxide [9]. Recently, methods of α-bromination using NBS in the presence of SiO 2 -NaHSO 4 [10], trimethylsilyl trifluoromethanesulfonate (TMS-OTf) [11], ammonium acetate [12], and solvent-free reaction conditions have been developed [13–15]. Photochemical α-bromination (λ = 200– 600 nm) has also been described [16].


Introduction
Bromination of ketones is an important reaction in synthetic organic chemistry [1] because bromoketones obtained this way are common intermediates in the synthesis of biologically active compounds.The bromination reaction constitutes the first step of introducing a heteroatom to generate stabilized carbanions [2] and support conjugation of the carbonyl group.

Results and Discussion
Here, I report a new procedure for the preparation of -bromoketones involving the reaction of enol triethyl borate with NBS (Scheme 1).The potassium enolate was prepared by treatment of the ketone with potassium hexamethyldisilazide (KHMDS).Potassium enoxytriethylborate was easily obtained by reaction of the corresponding potassium enolate with triethylborane.The generation of potassium enoxytriethylborate required a low temperature (−78 ∘ C), while the reaction of potassium enoxytriethylborate with NBS occurred at room temperature.Anhydrous reaction conditions (argon atmosphere, anhydrous solvent, and reagents) are necessary.
The -bromination method described in Scheme 1 showed high regioselectivity (Table 1).In addition, the yields of -brominated compounds were superior (87% and 90%, respectively, for 5-( 2) and 5-cholestan-3one (3)).Furthermore, the tert-butoxy protecting group tolerated the described reaction conditions.Some examples (cyclopentanone and 2-methylcyclohexanone) gave a mixture of products.A likely mechanism of compound 1 reaction is outlined in Scheme 2. A separate experiment of cholestanone (3) with KHMDS and NBS yielded a mixture of various products.
The typical experimental procedure was as follows: to KHMDS (1.1 equivalent of 0.5 M solution in toluene) under argon at room temperature a solution of ketone (1 equivalent) in dry THF was added.The reaction mixture became turbid.After 0.5 hour, the reaction mixture was cooled to −78 ∘ C,

Conclusions
In conclusion, I have developed a mild and efficient method for the -monobromination of ketones by treatment of their enol triethylborates with NBS.The simple procedure, high yields, and regioselectivity of the products are the advantages of the described method.