A Statistical Synopsis of COVID-19 Components and Descriptive Analysis of Their Socio-Economic and Healthcare Aspects in Bangladesh Perspective

The aim of the work is to analyze the socio-economic and healthcare aspects that arise in the contemporary COVID-19 situation from Bangladesh perspective. We elaborately discuss the successive COVID-19 occurrences in Bangladesh with consequential information. The components associated with the COVID-19 commencement and treatment policy with corresponding features and their consequences are patently delineated. The effect of troublesome issues related to the treatment is detailed with supporting real-time data. We elucidate the applications of modern technologies advancement in epidemiological aspects and their existent compatibility in Bangladesh. We statistically analyze the real-time data through figurative and tabular approaches. Some relevant measures of central tendency and dispersion are utilized to explore the data structure and its observable specifications. For a clear manifestation, Z− scores of the COVID-19 components are analyzed through the Box-Whisker plot. We have discovered that the gathered data exhibit features that are unsatisfactory for the normal distribution, are highly positively skewed, and are predominated by the earliest occurrences. Infections and deaths were initially lower than the global average, but they drastically rose in the first quarter of 2021 and persisted for the remainder of the year. Substantial preventive results were produced by the region-wisetime-worthy moves. In the fourth quarter of 2021, the infections and deaths noticeably decreased, and the number of recoveries was highly significant. In the middle of 2022, a lethal rise in infections was observed in Bangladesh and that was quickly stabilized, and the pandemic ingredients were under control. According to our assessment, some concluding remarks are made at the end of this work.


Introduction
Epidemiology refers to the cogitation and exploration of the spreading and natural attributes and forecasting of the public health risk factors assessed for a demonstrated population [1]. It is essentially related to the studies of the demographic behaviors of any target community. Due to the requirement of preventive measures the contemporary public health-related issues with the emergence of the betterment of healthcare technologies, the term epidemiology is now getting signifcant attention with practical importance [2]. Epidemiology is compactly relevant to infectious diseases, such as HIV, AIDS, infuenza, tuberculosis, Ebola, Nipah, and Zika [3].
Presently, highly contagious COVID-19 is the most conspicuous epidemiological phenomenon involving mysterious mechanisms of transfusions. In early 2020, after the December 2019 escapade at the city of Wuhan in China, the World Health Organization (WHO) proclaimed potentially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the perpetrator of grievous COVID-19 [4]. Tis natural disaster rapidly expanded almost all corners of the globe, including Bangladesh.
COVID-19 has a detrimental infuence on many elements of society and is especially harmful to individuals who belong to the most vulnerable social groups. Te unimpeded natural world of nonhumans conceals humanity. According to WHO, outdoor air pollution kills 7 million people worldwide each year, and more than 80% of the civil population is exposed to polluted air. More than 4 million deaths each year are globally caused by heart illnesses, strokes, lung cancer, chronic lung diseases, and respiratory infections (https://www.who.int/health-topics/airpollution). Tose issues were afected much more during the COVID-19 pandemic. Air quality and climate play an important role in the COVID-19 situation. During the lockdown, it is noticed that most of the hospitals were in deadly condition due to the lack of a hygienic atmosphere.
SARS-CoV-2 is an RNA-based virus that is a frantically transmissible virus with volatile strains and epidemic variants over the world [5]. Consequently, some irregular and successive transmission waves occurred in recent times. Te number and pattern of infections, deaths, and recoveries due to COVID-19 are varying with diferent variants [6]. Some variants of SARS-CoV-2 are eminently lethally and have no geographical bound. Te horrifc infectious genre of COVID-19 is now declared a pandemic by the WHO [7].
Bangladesh is a developing country in South Asia that is naturally beautiful. Te economy of Bangladesh is progressing rapidly and is in the way to acquire the Sustainable Development Goals (SDGs). It is noticed that every sphere of life including women empowerment has immensely developed in the last decade. However, the outbreak of COVID-19 has afected every sector of Bangladesh intensely [8]. In Bangladesh, community transmissions started and climbed exponentially in the frst quarter of 2020.
Earlier to the COVID-19 pandemic, the economy of Bangladesh was rising swiftly and earned on average a 7% increase in annual income. But due to the impact of the pandemic, according to the Bangladesh government, the rate of increase in annual income came down to 5.2%, whereas the government expected it to be 7.5% (https://www.unido. org/media/64590).
Te pandemic COVID-19 has had a vital impact on the global economy. According to the International Monetary Fund (IMF), till now, the global economy is decreased by 4.9% due to COVID-19 which is higher than any other consequence. Te safety measures against COVID-19 signifcantly reduced the workplace and workforces that remarkably hampered worldwide trade and business. Te International Labor Organization (ILO) reports nearly 1.6 billion workers lost their livelihoods which is about 50% of the total labor. More than half of global employers in several business and economic sectors are sufering from the efect of COVID-19. Te manufacturers, retail traders, and service-providing authorities are facing terrible hardship during COVID-19. As a part of the world economy, Bangladesh's economy was also severely invaded by the crisis of COVID-19. Te readymade garments sector is drastically fallen due to inactivity from the importers. Medium and small business entrepreneurship is about to destroy and service-providing institutions sent of the majority of their workers because of no work due to the lockdown. People of lower or lower-middle income suffered the most as they had no deposits for future survival.
Almost people in every economic class are downgraded within the contemporary COVID-19 pandemic, and the chain of socio-economic command structure is about to be badly impacted. Moreover, the agricultural sector of Bangladesh is damaged due to the transportation shortage during the lockdown. Detailed information about the world-wide economic crisis and compare to the situation in Bangladesh can be found in the Booklet published by the United Nations International Children's Emergency Fund (UNICEF) (https://www.unicef.org/bangladesh/media/ 5256/fle).
Te government of Bangladesh announced the outbreak of the COVID-19 virus in March 2020. Te Institute of Epidemiology, Disease Control and Research (IEDCR), the epidemiology institute of Bangladesh reported the frst three known cases on 8 March 2020 [9]. Te virus was spreading gradually over the county from then, and the number of infected cases also increased. Te Directorate General of Health Service (DGHS) announced daily reports; due to community transmission, 48 confrmed cases and 5 deaths are found on 28 March 2020 [10].
People who had any form of respiratory distemper are the vital suferers of COVID-19. Even someone who recovered from COVID-19 infection experienced long-term lung complexity [11]. Elderly citizens and patients with chronic diseases, such as cardiovascular disorder, diabetes, and other respiratory illness, are mainly afected by COVID-19 spreading waves [12]. Te COVID-19 virus can transmit from the infected people's mouths or noses as small liquid objects through cough, sneezing, and breathing with a range from aerosols to droplets.
Medical experts are worried about not having enough test kits to identify the infected people in the country. Newspaper, print media, and social media telecasted the latest news, awareness, and symptoms of COVID-19 [13]. Te government opened isolation centers over the country. Te COVID patient stayed in those isolation centers or home quarantine. During the pandemic, people of Bangladesh faced a shortage of medical-grade oxygen and intensive care unit (ICU) [14].
Tough several vaccines are discovered and a remarkable number of people are vaccinated worldwide, due to the consecutive appearance of newer variants no absolute preventive steps are found to impede COVID-19. Some public awareness steps are taken globally to minimize the massive number of infections, such as quarantine, isolation, and lockdown [15]. Tere are many reasons behind the lack of success in COVID-19 treatment that governments of many countries initiated, namely, poor medical infrastructure, communication breaches and lack of authenticity of the gathered information, and ignorance and unwillingness to the treatment from the side of civil populations [16].
During the spreading of COVID-19, a large number of studies are ongoing worldwide. A detailed analysis of the COVID-19 situation in China is statistically portrayed in [17]. Te signifcance of several parameters of COVID-19 infection in Saudi Arabia is statistically analyzed in [18]. A regression analysis-based prediction strategy for COVID-19 infections in India is studied in [19]. Te statistical measures of the factors behind the community transmission of COVID-19 in Pakistan through real-time data are provided in [20]. A comparative analysis of COVID-19-related deaths in urban and rural arrears of the United States is discussed via statistical data illustrated in [21]. Recently, based on the comprehensive data of COVID-19 in Tailand, reconstructive transmission dynamics via stochastic modeling technique is studied in [22].
In this work, we are willing to elaborately discuss the socio-economic and healthcare scenario of COVID-19 spreading from the perspective of the people of Bangladesh, including the components of the treatment and accompanying troublesome issues that obstruct the treatment strategies. Te discussion includes the impact of the age of information and the Internet of Tings on the COVID-19 situation and their applicability in Bangladesh. Te statistical manifestation and analogous discussions with recommending opinions will be provided as well.

Methodology
Te present work can be partitioned into two basic categories. One is the descriptive analysis of the COVID-19 situation and associated socio-economic and healthcare aspects, and the rest is the statistical analysis of real-time data collected from various authentic sources.
In the beginning, the progression of COVID-19 in Bangladesh is narrated sequentially in Section 3. Te commencement of COVID-19, sequential phenomena, and information about the healthcare authorities, and the monitoring body in Bangladesh are discussed in this section. Sections 4 and 5 consist of the components of COVID-19 and the issues impeding COVID-19 treatment in Bangladesh, respectively. Te description of lockdown, quarantine, isolation, variants, and vaccinations are included in Section 4. In contrast, the reasons behind the impediment of COVID-19 treatment, such as ignorance and unwillingness of the mass people, scarcity of treatment facilities, the efect of diferent variants, economic crisis, and the impact of illiteracy are provided in Section 5. Section 6 covers the discussion on the importance of the age of information and the Internet of Tings in the safety measures for COVID-19. Te situation of those factors in Bangladesh is included in this section as well.
Section 7 contains the main task of this work. Te mechanism of collection and their statistical analysis are included in this section. Both graphical and tabular approaches are applied to manifest the real-time data of COVID-19 in Bangladesh. For an understandable analysis, measures of central tendency and dispersion are investigated along with an inquiry into Z-scores of the COVID-19-related components. Graphical and narrative analyses of every component are explored individually. Also, a detailed observation of the vaccination processes is delineated. Time, place, and the wave-based analysis of COVID-19 components are presented. Te fndings and discussion are made in Section 8.

COVID-19 Spread in Bangladesh
In this section, commencement of COVID-19 in Bangladesh, sequential phenomena, and the healthcare authorities along with the monitoring body are discussed.  In Bangladesh, the very frst confrmed case of COVID-19 was found on 3rd March 2020. On 18th March 2020, three nonresident Bangladeshi males returned from Italy and Kuwait along with a female, and the next day a family consisting three members returned from Italy once again. Tose people had the symptoms of COVID-19 and that enhanced the community transmission of the COVID-19 [23]. Te maiden death due to the outspread of COVID-19 was occurred on 21st March 2020. On 22nd March, a doctor died and many people found infected. Up to 23rd March 2020, in total, 23 healthcare workers were found to be infected; two more returnee were from India and Bahrain. Some returnee from Saudi Arabia and 4 locals were identifed with COVID-19 morbidity on 24th March 2020; another death of the female that happened was linked to the community transmission [24]. On 3rd May 2020, recovery rates were grown up and reached to 1000 according to the governing authorities. On 13th June 2020, the total number of COVID-19 cases in Bangladesh exceeded the total number of COVID-19 cases in China. Just after two days of exceeding the total number of infections, the total number of recoveries from COVID-19 in Bangladesh has overtaken the total number of recoveries in China [25]. According to the government agencies of Bangladesh, up to 15th June 2020, about 15,000 patients were recovered from COVID-19. Many of the recovered people were not even recorded in the infected list, and outside the hospitals, many people recovered from COVID-19 infection by taking traditional home-made medications.

Sequential Phenomena.
Initially, the people of Bangladesh were unaware of the deadliness of COVID-19 and hence apathetic to the healthcare rules and emergencies announced by the government. Due to the scarcity of skilled medical workers, a signifcant number of people were uncovered from the scheduled activities performed to handle COVID-19 spreading. As the consequence, community transmission happened rapidly [26]. Over time, the healthcare authority had taken the control of the situation and community transmission came to a submissive state. As Bangladesh is a densely populated country, the laboratories were insufcient for testing huge numbers of people. At the beginning, coronavirus cases were tested using only realtime reverse transcription-polymerase chain reaction (rRT-PCR) technique and, in December 2020, the government gradually increased the healthcare service facilities with hands-on training with the help of WHO [27]. To stop the prevalence of the virus, the government announced a "lockdown" throughout the country from 23rd March to 30th May and took some necessary steps to propagate the consciousness about the virus [28]. Te country saw an elevated infection rate on 11th April 2020 which was the Journal of Environmental and Public Health 3 highest in Asia compared to March 2020. Te government confrmed that all districts are under the cases on 6th May. Te number of identifed cases passed the number of identifed cases in China, the country where the outbreak began by an unknown cause on 13th June. Moreover, Bangladesh reached the stern milestones of 160,000 cases and 2,000 deaths on 5th July. Some peaks were observed in the number of infections and deaths from July 2020 to June 2021, and then, both of them gradually came back to under hundred at the beginning of the year 2022 [29]. In contrast, the number of recoveries was trivial at the very frst stage of the spreading of COVID-19 but it progressively grew with the initiative taken by the government, and after June 2021, it attained a swift pace of increment, which provides relief from the lethal threat.

Healthcare Authorities and the Monitoring Body.
To superintend the COVID-19 situation and make crucial decisions, signifcance of the healthcare organizations and their monitoring bodies are unavoidable. Te DGHS of Bangladesh is the principal authority to observe, analyze, and make decisions on public health issues, which remained invariant in COVID-19 afairs as well. DGHS collected, stored, and published the statistical data related to COVID-19 [30]. It also circulated public instruction and recommendations for the dues of the government in this pandemic situation. In parallel to the DGHS, mass people could collect the COVID-19 related information from Corona Info, which consisted of the fgurative data representation related to COVID-19 in Bangladesh. IEDCR is an experimental research institute under government support that is functioning on infectious and epidemiological diseases in Bangladesh and their control. IEDCR worked in collaboration with DGHS to make the COVID-19 situation feasible [31]. IEDCR provided some hotline numbers, e-mail addresses, and a Facebook page for people to contact if they suspect COVID-19 infection or need more information. Te Ministry of Health of Bangladesh is the monitoring body for healthcare matters in Bangladesh, which was managed to best ft the collaborative activities of DGHS and IEDCR in the COVID-19 breakout.

Components Related to COVID-19 Treatment
Te immensely infectious COVID-19 outbreak afected all over the country's healthcare system and transmitted to mass people at an expeditious pace. COVID-19 is a new form of deadly virus SARS-CoV, which is transmissible between humans in diverse ways. In the beginning, the treatment procedure for this disease is poorly understood, and keeping social distance, wearing mask, and maintaining apt sanitation were the basic forms of treatment [32]. Ten, some form of institutional activities for controlling COVID-19 is initiated, for instance, isolation, quarantine, and lockdown. Since COVID-19 is an RNA-based virus that is able to change its strain, there were several variants found, and still, new variants are coming in sequence. So, treatment of COVID-19 infection was obtrusive [33]. Time-demanding vaccines were discovered, and vaccination campaigns were carried out throughout the country later on. Tere were some vaccines discovered, commercially produced, and supplied by some worldwide renewed medicare companies supported by WHO. Te conspicuous and prominent components related to the treatment of COVID-19 are discussed below.

Lockdown.
Social distancing was one of the eminent options to reduce the community transmission of the COVID-19 infection. As the requirement of the treatment policy of COVID-19, the government of Bangladesh declared a zone-wise lockdown in the country several times [34]. In order to handle the COVID-19 crisis, the lockdown was retained by shutting down everything but hospitals and other healthcare facilities. At airports, the authorities were watchful to detect any infection in passengers who were traveling from aboard (https:// www.theindependentbd.com/post/233343). Travelers who had 100 degree Fahrenheit body temperature were examined through thermal cameras. Ten, in Bangladesh, the frst three confrmed cases reported positive as COVID-19 patients on March 8, 2020 (https://crisis24.garda.com/alerts/2020/03/ bangladesh-frst-cases-of-COVID-19-confrmed-march-8) and immediately shifted to hospital. One of them was announced frst death from coronavirus by the healthcare ofcials on 18th March 2020 at Dhaka (https://www.reuters.com/article/healthcoronavirus-bangladesh-idUSL4N2BB384) [30]. After that, on 22nd March, the government declared the frst lockdown to reduce the spread of the COVID-19 and except emergency services all the public and private sectors were shut down (https://archive.dhakatribune.com/bangladesh/2020/03/23/govt -ofces-to-remain-closed-till-april-4). In the meantime, the hospitals were preparing for the treatment procedure and laboratory experts for testing samples of the suspected patients who have coronavirus so that they can take necessary steps for the COVID-19 positive patients [35].
But the testing rate raised from mid-March, so the Bangladesh government again announced a second lockdown as the second wave arrived with an alarming turn in the country (https://archive.dhakatribune.com/bangladesh/ 2021/04/17/experts-bangladesh-s-second-COVID-wavehas-peaked-situation-likely-to-improve-in-may).
Meanwhile, it was reported that with the prolonged lockdown, the academic activities immensely fell down and educational institutions went under severe uncertainties [36].
Bangladesh regularly rose up to new cases and the third wave with a new variant came up in a disaster situation. So, another lockdown was declared by the government, and the Bangladesh Army (BA) and Border Guard Bangladesh (BGB) deployed to stop people leaving their house without any emergency (https:// archive.dhakatribune.com/bangladesh/2021/06/25/bangladeshgoes-into-nationwide-hard-lockdown-from-june-28). But for the sake of livelihood and the mild rate of the virus spread, the lockdown period ends [37].
Minimum 32 Bangladeshi people died of COVID-19 in the frst week of July 2022. As a result, Bangladesh government declared a campaign, named "no mask, no service" in all ofcial and public locations. Tus, an implicit lockdown imposed due to this sudden raise of the death rate (https://www.aljazeera.com/news/2022/7/6/fourth-wave-do zens-die-of-covid-in-last-5-days-in-bangladesh). Detailed information about the waves is unveiled in Table 1, and lockdown of COVID-19 in Bangladesh is unveiled in Table 2. It is to be noted that no salient lockdown is imposed in the fourth wave of COVID-19 in Bangladesh.

Quarantine.
Te term quarantine refers to keeping people away from the social interaction. During the pandemic like COVID-19, due to the chain of lockdown, there was no choice for the people and they had to quarantine themselves. When COVID-19 started in Bangladesh, due to fnancial and social phenomena, people had to work together and many of them were silent carriers of COVID-19. As a result, many of the workers and labors had to go under quarantine [38]. Many healthy people were fnding it diffcult to survive in such a condition, and everyone had to observe quarantine for few days. After completing the quarantine period, some of the suspected incoherent people quarantined themselves for at least two weeks apart from others as they found mild symptoms of COVID-19. In contrast, others went back to the society due to no further symptoms of COVID-19.
Tere are some protocols imposed by the government during the quarantine for controlling COVID-19 in Bangladesh. Measures are taken to increase social distancing among the people to limit or stop the transmission of the virus. Tis includes avoiding large gatherings, limiting the number of visitors to your home, working from home, maintaining safe distances from others, contacting friends and family online rather than in person, and if necessary, wearing personal protective equipment (PPE) [39]. As a result, the spread of the virus has slowed down reducing the maximum number of patients, thereby easing the strain on hospital infrastructure and needs. Because of quarantine, the maximum number of cases caused by the virus eases the pressure on resources and hospital demand is reduced by slowing the spread of the virus.
Physical activity decreased, lack of social interaction, and staying home is a boredom; these caused problems among people. Restriction of social interaction and not going out made things way beyond complicated at a stage of pandemic. Te fear and anxiety level increased within the people, and working from home was not easy for all. In Bangladesh, the study of psychological behavior within quarantine is mainly afliated with stress and loneliness symptoms [40].
A study on the quarantine in Bangladesh perspective portrayed that the efects of the home quarantine is profoundly connected to the psychological aspects and had noteworthy impact on psychological matters throughout COVID-19 pandemic. Lack of healthcare awareness, medical opportunities, and monetary assurance were the most noticeable impediments of the quarantine process in Bangladesh [41].

Isolation.
Te word "isolation" originates from the fact that the incidence of COVID-19 is increasing and people are not being given any place in the hospital. In such a situation, doctors advised that it would be wise not to come to the hospital unless the condition is very critical now. Before going into isolation, they were divided into two categories and the two types of people were kept in isolation: those who have been tested for COVID-19 and those who have not. Some of the isolated people had lack of oxygen saturation and were treated as infected and were needed to take medicare. Later, some people recovered and some of them died [42]. It was found that the number of recovered patients was increasing day by day and reduced the rate of afected patients after the isolation.
Some people took isolation in a negative way. During the sickness due to the COVID-19 infection, in the isolation period surviving alone seemed to be very tough and it greatly afected the people psychologically. Anxiety and fear of death came across their minds in that dangerous time of COVID-19. Some diseases stayed forever with them after sufering from COVID-19. So, this is a concerning topic to discuss otherwise they cannot fght with the virus [43]. Our body reacts how we want it to react, so if anxiety and depression grab you, then it would be very difcult to turn back. Isolation is marked as one of the prominent catalysts of mental instability during COVID-19.
In Bangladesh, some people researched it, and according to their analysis, it is observed that more than 50% isolated people sufered from anxiety and depression; to be exact, they are 52.7% and 52.2%, respectively. Out of them, a signifcant number of isolated people had acute manifestation of anxiety and depression, which is defnitely a fatal extent [44]. Dealing with the pandemic situation was not easy for everyone to handle alone. Every family does not have separate rooms for all the members; during that time, if one member is COVID-19 positive, it is very difcult to manage and keep everyone safe. Also, those who were isolated cannot be taken care of by others. Some cases with suicidal attempt were also noticed throughout the pandemic period [45]. A meta-analysis exhibited that pervasiveness of anxiety and depression among the isolated people with COVID-19 is remarkable and statistically their rates are 47% and 45%, respectively [46].   [47]. Te entire genetic structure of the coronavirus is contained in RNA (ribonucleic acid). Tough not identical, RNA and DNA have some similarities. When a virus infects a person, it binds to human cells, enters them, and makes copies of its RNA to help spreading. RNA is varied if a replication error occurs. Usually, viruses change their genetic structure and gain the transmission potential as they circulate among people over time [48].
We talk about "variants" when these modifcations are entirely divergent from their original form. Scientists analyze the virus's genetic makeup to fnd variations and then check for diferences to see if there are any changes. Variants of the SARS-CoV-2 virus, which produce COVID-19, have emerged and been detected in several countries worldwide following the global spread of the virus [49].
Another example is delta variant. WHO classifed the delta version as a variant of concern on May 11, 2021, and it is currently the most widely circulated variant worldwide [50]. Compared to previous virus strains, the delta variant spreads faster and is responsible for more number of cases and deaths worldwide. Te delta variant is protected against all licensed COVID-19 vaccines currently in use, and all of them are safe and efective [51].
It is perceived that in the third wave, when the delta variant was spreading, new cases rate rose up to 13,817 just before the lambda variant came up. Also, the highest number of deaths of 264 was found at that time.
Diferent variants came up with diferent symptoms which efected the treatment category for dealing with concerning cases. Tis became a directing factor in the treatment facility as well as in the general people for maintaining more safety. During lockdown, in diferent waves variety of variants took place in our country from the origins of the variants [52]. Te variants of COVID-19 have diversifed attributes. Some are highly infectious, some are very deadly, and some of them are ancestors of further healthcare complexities, especially, heart, kidney, and lung infections. So, the continuous arrivals of the variants of COVID-19 made the impediments of exact treatment approach, which enhanced the scarcity of the control of COVID-19 situation in Bangladesh [53]. In Table 3, the variants of COVID-19 detected in Bangladesh are delineated along with their origins and dates of detection.

Vaccinations.
Vaccination is a primordial and prominent apparatus for preventing the infectious disease like COVID-19. To combat against COVID-19, vaccination is a safe zone for people because vaccine builds natural immunity to a disease in our body before we get sick or infected with some virus. On June 21, 2020, Bangladesh got the rights to proceed from China to vaccinate general people to fght with the lethal virus COVID-19 (https://archive.dhakatribune.com/health/coronavirus/2020/06/ 21/COVID-19-bangladesh-to-get-priority-if-china-develops-vac cine). It started from January 27, 2021, and Bangladesh government decided to start mass vaccination from February 07, 2021 with the Oxford-AstraZeneca vaccine (https://www. aljazeera.com/news/2021/1/28/bangladesh-starts-COVIDvaccination-drive) and targeted to reach 6 million doses in the frst month and 5 more million within the next month (https://www.thedailystar.net/frontpage/news/historic-day-2035021). Te COVID-19 vaccines which have been approved for use by WHO and assumed to be applied in Bangladesh are addressed below with a brief idea for each of them.     Journal of Environmental and Public Health 7 American company Pfzer incorporated to BioN-Tech for the clinical trials, logistics support, and production of Pfzer-BioNTech vaccine in the process of development. Pfzer-BioNTech is 93.7% and 88.0% efective against alpha and delta variants, respectively [57]. Another version of Pfzer vaccine is called Pfzer-PF, which is initially introduced as an oral/nasal dose of vaccine efective for individuals of 12 years age and older [58]. Moderna is found to be efective for the delta variant [62]. Moderna is eligible for the treatment of pregnant women as well [63].
A viral vector vaccine produced through the genetic material coding for a target antigen within the recipient's host cells. An inactivated vaccine contains some virus, bacteria, or other cultivated pathogens and killed them for destroying the infectious viruses. An mRNA vaccine includes the messenger RNA (mRNA) to generate the internal immunity.

Troublesome Issues Accompanying to COVID-19 Treatment in Bangladesh
In this section, we will narrate some incommodious issues that engendered obstruction of COVID-19 treatment in Bangladesh. Some of them originated from the side of mass people due to illiteracy and passiveness, and the rest of them sprouted from the defciency of systematic healthcare infrastructure and economic expediency.

Ignorance and Unwillingness to the Treatment. Most
Bangladeshi people are not acquainted with the signs and impacts of pandemics. Tey were confused with the symptoms of COVID-19 and the other fu-related fevers.
Tey had no idea about the aftershock of the waves of COVID-19 variants and were not aware of the lethality of this infectious disease. Due to the ignorance of the spreading of COVID-19 and unwillingness to the healthcare strategies, the community transmissions were elevated signifcantly [64]. Some of the people were naturally resistant to the infection owing to the presence of desired antibodies; this fact highly encouraged the uneducated and troublesome to be reluctant to the steps taken by the government to minimize the rate of COVID-19 infections. Some people were unnecessarily overconfdent about their health issues and thought they will not be afected by the COVID-19 infections, which was another cause of unwillingness [65]. A few cases of ignorance were caused due to the defcit of trust in the COVID-19 protective measures. Overall paucity of proper healthcare education and insufcient knowledge about the pandemics are the fundamental source of ignorance and it made the Bangladeshi people unwillingness to the COVID-19 treatment, and hence, the rate of infection climbed conspicuously [66].

Lack of Treatment Opportunities.
As a third-world country, Bangladeshi people face a lack of treatment opportunities due to insufcient infrastructure and scarcity of skilled healthcare personnel. During the COVID-19 period, the hospital conditions started worsening. It goes the same for those who admitted and those who could not get a single place in the hospital. Even some doctors did not attend the hospitals regularly at that time. Family members had to go through a tough time managing everything. Although the quality of medical equipment and standard training process are improving over time but they are yet to be plentiful for the extant demand [67]. Te defciency of the proper ventilation system and exiguous medication made the contemporary pandemic scenario awful. Te people of Bangladesh are not habitual to infectious diseases like COVID-19; that is why the preparation to deal with COVID-19 was incommensurate [68]. Although much medical equipment was managed in the peak of the infection, the apathy of some of the healthcare authorities is another cause for the increment in the number of COVID-19 patients present in Bangladesh [69].

Lower Economical Structures.
Bangladesh is a developing country, and people who are under privilege do not maintain a healthy lifestyle. Poverty is the problem here; they cannot aford the cleaning products to maintain the COVID-19 precaution situation. Some of their lowerincome occupations or lower economical ability do not support extra expenses [73]. People who drive rickshaws, laborers, and local shopkeepers cannot survive with the high precautionary system of COVID-19 [74]. Usually, they do   Tird dose  Total  AstraZeneca 20743272  19254707  11949390 51947369  Pfzer  22306024  20710925  25690994 68707943  Sinopharm  56364937  53985721  217  110350875  Moderna  3778926  3547557  8481643  15808126  Sinovac  27156813  24583986  3371201  55112000  Janssen  0  456284  1053  457337  Pfzer-PF  1250662  0  0  1250662  Total  131600634 122539180  not maintain a proper hygiene environment. For that, the awareness of hygiene is not proper enough for covering this situation. Te frst condition of COVID-19 is to maintain hygiene properly. But they do not have proper guidelines and a lack of awareness causes more sufering.

Superstitions and Rumors.
Some people in society think that this whole pandemic situation and COVID-19 cannot do any harm to them. Tese superstitious things mislead some people from the real situation of COVID-19. So-called religious matters are sensitive cases but some people use them inappropriately and outspread wrong information. Tey think the almighty will save them without any medication; this pandemic is given for some reasons. Tis kind of illiteracy is leading people from ignoring the COVID-19 situation [75].
Tere was a rumor propagated that COVID-19 is an infectious disease in wintry countries and will not spread to warm countries like Bangladesh. As a consequence, people were leading their regular life without preventive measures which caused a higher rate of infection of COVID-19.

Impact of Age of Information and Internet of Things in COVID-19 Situation
In this section, we will discuss the importance and aptness of age of information and Internet of Tings and their infuence in epidemiological circumstances. Also, the present scenario of age of information and Internet of Tings are highlighted according to Bangladesh.

Age of Information.
Te modernization of information is a burning issue in the present era of information technology because of its practical functionality [76]. A naturalistic data update process is signifcantly demanding, which consists of the composition of network-based data monitoring, tactical connections, multiconnecting modules, internet-based data station, human-computer interfaces, and physical security systems [77]. Due to lack of efectiveness and data modernity, classical communication devices are being replaced with updated and optimized data analysis tools [78]. AoI is an auspicious and potential assessment of data expediency that clarifes the adaptability and sustainability of the latest installed devices. For controlling the collaborative information updates with adequate credibility, the worth of AoI is unavoidable.
In the emergence of open-source feasibility and computer-aided data analysis, AoI has a crucial role. AoI is indispensable for the trustworthiness of collected data and their further accomplishment [79]. Statistical measures of the collected data must be highly contingent on their practical eligibility and aspects of biophysics, which are the preeminent features of AoI [80]. Assumption of the future circumstances according to the contemporary ambiance is obligatory, which can be empirically ascertained through the AoI [81]. In epidemiological situations, healthcare techniques can be contemplated according to the structure of the collected data, their accuracy, change of atmosphere over time, and the infrastructural ability of the healthcare authority [82,83]. In those attributes, regularity and positiveness of the collected data are the most important aspects, which can be justifed through AoI [84]. AoI is tightly connected with the methodological updates and enhancement of their systematic utilization for statistical analysis of epidemiological factors [85]. In the existent COVID-19 pandemic, optimal accuracy of the collected data is inescapable due to the safety measures and decision-making for treatment strategies, which is linked to AoI rigorously [86].

Internet of Tings.
In the present day, the Internet of Tings (IoT) is playing a key role in the advanced technologies of the data collection process and their statistical analysis [87]. Assignation of IoT is exigent for the convenience of storing allotment in computing devices, efcient data dissemination, and rapid access to remote data servers [88]. Recently, Artifcial Intelligence (AI) has been commonly incorporated with IoT, which can efciently accumulate and categorize real-world data through remote sensors and their computational applications without the physical presence or human-based schemes [89,90]. Te term machine learning (ML) is deeply compacted to IoT for the purpose of statistical experiments, including similarity analysis, data forecasting, and pattern recognition of real-time data with the optimal time and cost [91,92]. In the current epidemiological calamity, the requirement of IoT is unavoidable due to the expeditious remote access to treatment-related information, distant workload distributions, and methodical updates from the decision-making healthcare ofcials [93].
ML processes for statistical modeling are becoming more standard in the literature of epidemiological studies. Tese techniques have the potential to vastly expand our understanding of health and the available interventions, far exceeding our existing capabilities [94]. To improve treatment outcomes, hospitals and research facilities will utilize AI to train machines to handle data rapidly and efectively. Te functions that programs may carry out include treating strokes, identifying heart problems, and improving diagnostic radiology skills [95]. Being updated about the pertinent situation is essential for setting up the preventive measures against the community transmission and related components of COVID-19, which is the prime concern of IoT [96].
COVID-19 has caused immense sufering, loss of life, and death. Te ease with which this form of coronavirus can spread highlights the faws in many healthcare systems around the world. Many governments, scientifc, commercial, and other institutions and interest groups around the world have fought the disease in various ways since its outbreak. Science and technology have helped several countries mitigate the efects of the pandemic and implement programs aimed at identifying and treating diseases. Modern technological methods, especially AI tools, are also being researched to track coronavirus transmission, identify those at a high risk of dying, and diagnose patients with the condition [97]. Detection and diagnosis of COVID-19 are essential to campaigns against the virus. Current noninvasive diagnostic analytical techniques include breast CT and chest X-ray imaging, bimolecular, serological, and viral throat swab tests [98]. Rapid and early diagnosis and  surveillance of infected individuals are critical to contain epidemics and isolating viruses, and there is a desire for innovation in this area [99].

Scenario in Bangladesh.
In Bangladesh, because of the factors mentioned in the previous section, preserving the fundamental features of AoI was immensely challenging and inconceivable for some afairs. Consequently, policymakers were in a dilemma at the initial stage of the COVID-19 situation. Gradually, the environment went under control at the beginning of 2021, and healthcare activities are feasible.
From Bangladesh's perspective, due to technological defciency and insufciency of skilled computer-based medical analysts, IoT is still not in the fully efcacious stage. But the situation compelled the advancement of IoT in Bangladesh during the existent epidemiological catastrophe. After the initial wave of COVID-19, the Bangladesh government took necessary steps to ensure the unbounded fow of information. Ministry of Health directly monitored the COVID-19 phenomena and maintained a public database, both on the website and regular announcements through various sources of social and printed media. Data analysts and medical professionals worked together for a smooth information fow under the guidance of governmentafliated healthcare institutions, namely, IEDCR and DGHS of Bangladesh.

Accumulation of Statistical Data of COVID-19 Components and Their Interpretative Analysis
In this section, statistical analysis of some COVID-19 occurrences in Bangladesh is portrayed through fgurative and expository approaches. Prior to doing the statistical analysis the scheme of data collection referencing the appropriate sources and time period is stated elaborately. Measures of central tendency and dispersion are depicted for the real data and a more refned view is presented through Z− scores (standardized value) of COVID-19 components. We are aiming to discuss the number of tests, infections, deaths, recoveries, quarantines, isolation, and a detailed review of vaccinations.
Here, we aimed to analyze the data up to 30th September 2022. For the number of tests, infections, deaths, and recoveries from 8th March 2020, whereas for number of quarantines and isolations the data are admissible from 20th December 2020. Te data for vaccinations are available from 27th January 2021 for the frst dose, 8th April 2021 for the second dose, and 21st December 2021 for the third dose. Te maximums of the COVID-19 components are far ahead of their average values. In comparison to the average values, the mean deviation and standard deviation are found very high. For almost every component, the mean deviation is about 100% of the average, whereas it is about 150% for the Standard deviation. Tose measures of dispersion are close to 60% only for the number of tests. Te measures of the quartiles display the nonequidistant positioning that indicates a nonuniform distribution of the target data. So, from the graphical testimony, it can be claimed that the COVID-19related data are moderately scattered and have noticeable irregularity.
Since the magnitudes of the data of COVID-19 components are unequal, a collective comparison is not possible in their current values. As the remedy of this problem, the Z− scores of the desired components are estimated and exhibited them through a Box-Whisker plot as shown in Figure 2.  all of the components were very high initially and gradually diminished over time with some inconsistency.

Number of Tests.
We are willing to investigate the daily number of tests (suspected cases) and the division-wise total number of tests in Bangladesh. Figure 3 displays the daily number of tests from 8th March 2020 to 30th September 2022. Tere are some peaks indicating the extensive number of tests were done. Te test includes polymerase chain reaction test (PCRT) and rapid antigen test (RAT). Tree massive peaks are found on 12th April 2021, 3rd August 2021, and 25th January 2022 for number of tests 34,968, 55,284, and 49,492, respectively. Figure 4 reveals the division-wise total number of tests in Bangladesh. From Figure 4, it is evident that highest number of tests occurred in the Dhaka division with 5,951,657 cases followed by the Chittagong division with 3,044,602 cases, whereas lowest number of tests occurred in the Barisal division with 311,092 cases.

Number of Infections.
We investigated the daily number of infections (confrmed cases) and the division-wise total number of infections in Bangladesh. Figure 5 displays the daily number of infections from 8th March 2020 to 30th September 2022. Some peaks are found indicating that a large number of infections happened. Te noticeable peaks were on 7th April 2021, 28th July 2021, and 25th January 2022 for number of infections 7626, 16,230, and 16,033, respectively. Figure 6 reveals the division-wise total number of infections in Bangladesh. From Figure 6, it is apparent that the highest number of infections occurred in the Dhaka division with 950,132 cases followed by the Chittagong division with 308,537 cases, whereas the lowest number of infections occurred in the Mymensingh division with 40,690 cases. Figures 7 and 8 exhibit the countrywide daily number of deaths and recoveries in Bangladesh from 8th March 2020 to 30th September 2022. Figure 7 depicts that the maximum number of deaths was observed on 5th and 10th August of 2021 with 264 deaths. Also, 112 deaths were occurred on 19th April 2021. Figure 8 expounded that the topmost number of recoveries was attained on 8th August 2021 with 16,627 recoveries followed by 13,853 recoveries on 13th February 2022. Also, 7266 recoveries were viewed on 28th April 2021. A strange incident was observed on 15th June 2020 that number of recoveries abruptly lifted to 15,297, which is an irregular phenomenon. It might have happened due to some late entry of recoveries at a time.

Number of Quarantines and Isolations.
Te daily number of quarantines and isolations from 20th December 2020 to 30th September 2022 are exposed in Figures 9 and 10, respectively.
From Figure 9, it is obvious that the greatest number of quarantines were 10,333 on 30th July 2021. Another two discernible peaks are found for 3413 and 6037 quarantine cases on 22nd April 2021 and 26th January 2022, respectively.
From Figure 10, it is decisive that the largest number of isolations is 5138 on 27th July 2021 followed by 5022 isolations on 2nd August 2021. One more peak for isolations was found on 28th January 2022 with 2626 isolation cases.  Table 4. Figure 11 displays the number of daily vaccinations from 21th January 2021 to 30th September 2022, whereas Figure 12 shows the daily vaccinations for particular doses in the same time schedule. Figure 11 represents that highest number of vaccinations were occurred on 26th February 2022 with 11 Figure 13 illustrate the synopsis of the type-wise vaccinations with appropriate dates in Bangladesh for the frst, second, and third doses, respectively, within the target time period. From Figures 13(a)-13(c), it is palpable that Sinopharm vaccine was the most widely distributed vaccine for the frst and second doses, whereas Pfzer vaccine was major in the third dose of vaccination. On the basis of daily vaccinations, Sinovac, Sinopharm, and Pfzer vaccines were leading in the frst, second, and third doses of the vaccinations, respectively. A comprehensive outline of typewise maximum vaccinations including the dates is demonstrated in Table 5.
Note that, the vaccine Pfzer-PF was involved in the frst dose of the vaccinations, whereas no Janssen vaccine was included in that dose. Figure 14 portraits the division-wise vaccinations status in Bangladesh, whereas Table 6 conveys the summary of the division-wise vaccinations information. Figure 15 discloses the district-wise vaccinations status in Bangladesh, whereas Table 7 apprises the summary of the district-wise vaccinations information. Te vaccination coverage more than 100% indicates the number of vaccination exceeds the number of residences due to entry of people from other districts.

Wave-Wise Distribution of COVID-19 Components.
Here, the wave-wise summary of the occurrences of the COVID-19-related components in Bangladesh is provided in tabular form. Table 8 exemplifes the wave-wise distributions of the COVID-19 pandemic-related components at a glance.

Findings and Discussion
Statistical analysis of the data gathered from COVID-19 components conveys their nonuniform shape and irregular arrangement. Te target data failed to acquire the pattern of Normal distribution with conspicuous positive skewness. For Bangladesh, the dominance of the causation of the components is observed at the beginning of COVID-19.
From the fgurative comparisons of number of tests, infections, deaths, and recoveries, it is obvious that from the beginning to the third quarter of 2021 the COVID-19 situation in Bangladesh was very similar for all of the mentioned components. Tey had some noticeable cusps on July 2020, April 2021, August 2021, and January 2022, while the third one was the topmost. After January 2022, all of the mentioned components were gone down except some slight scatterings in July 2022. Te number of tests, deaths, and recoveries are precisely followed the trend of the number of infections. Te number of deaths was contemptible in comparison to the number of infections and clearly outplayed by the number of recoveries. In division-wise investigation, it was found that for both number of tests and infections, Dhaka division was at the pinnacle chased by the Chittagong division. But Barisal and Maymensingh divisions were at the undermost in the number of tests and infections, respectively. Te number of quarantines and isolations defned the identical trend of the abovementioned components but data were mission before December 2020. Tey had unerringly the same aptitude of the number of infections in the timeline of their data availability. Te number of quarantines was triumphed over the number of isolations, which is the indicator of the insufciency of institutional amenities.
From the compendium of the type-wise vaccinations in Bangladesh for the doses, it is apparent that for the frst and second doses Sinopharm vaccine was the dominant one, but Sinovac and Sinopharm vaccines were provided as daily maximum vaccinations in the frst dose and second doses, respectively. Pfzer was the leading vaccine type in the third dose of vaccination and maximum daily vaccinations were recorded for the Pfzer vaccine as well. From the given diagram of division-wise vaccinations, it is distinctive that the Dhaka division was under the maximum coverage and the Barisal division was under the minimum coverage for both the frst and second doses, while in the third dose of vaccinations the Khulna division advanced to the frst position and the Mymensingh division went to the bottom with the coverage. From the District-wise vaccination coverage, it is identifable that for the frst and second doses of vaccination the Gazipur positioned maximum, whereas Chuadangla reached to the top for the third dose. Te Jhalokati, Shariatpur, and Gaibandha settled to the bottom of the vaccination coverage for the successive doses.
From the wave-based distribution of the COVID-19 related components, it is intelligible that the third wave of the COVID-19 propagation was the most momentous for all of the components.
During the COVID-19 pandemic, every family in Bangladesh had a tough time managing their livelihoods and medical necessities. However, with the advancement of medical science, scientists discovered some efective vaccines that resulted comprehensively and helped the people to get back to our habitual life. In this case, if people were aware about some precautions from the beginning, they might be able to minimize the deadly losses. For example, they were alert enough in immigration so that without the afrmation no one was allowed to enter from foreign countries. By closing down transportation through the border, we could stop those COVID-19-infected peoples who entered. Also, following the lockdown strictly and correctly from the very beginning community transmission could be diminished. If we could maintain these steps, it might lessen the loss during the COVID-19 period.  Tested  296168  640345  1705258  305632  Infected  44573  117250  493294  36466  Death  607  2039  8989  164  Recovery  9368  119837  430659  41858  Quarantined  Not found  52489  293042  19229  Isolated Not found 15252 158908 5173

Conclusion
In this work, we have discussed the COVID-19 spreading in Bangladesh including the initial situation with the sequential phenomena and authorities concerning the healthcare administration during the pandemic. Te basic components related to the COVID-19 treatment and corresponding obligations are pointed out regarding circumstances in Bangladesh. We investigated the troublesome issues that impede the COVID-19 methodical treatment opportunities in Bangladesh. Te socioeconomic and healthcare issues are assimilated in this work for their intrinsic correlation to public health afairs. A consolidated discussion comprised the importance of the age of information and the Internet of Tings with their existent status in Bangladesh. We have analyzed the component related to COVID-19 in Bangladesh perspective in both fgurative and tabular methods. We have statistically analyzed the collected data related to the COVID-19 occurrences in Bangladesh in fgurative and expository forms. We analyzed the measures of central tendency and dispersion for the real-time data of COVID-19 components. A more comprehensible analysis of the structure of data of the desired components is exhibited through the Box-Whisker plot with a detailed explanation. Te components are the number of tests, infections, deaths, recoveries, quarantines, and isolations. An elaborate discussion on the vaccinations is provided with countywide delineation. Also, a wave-based distribution of the components associated with COVID-19 is displayed. Moreover, some of our fndings and suggestions are provided at the end. It is apparent from the statistical analysis that the COVID-19 component data do not obey the characteristics of a normal distribution and have moderate scatterings. Te data's quartiles are not evenly distributed, and their positive skewness has a long right tail that is an indication of initial dominance of the COVID-19 components and the gradual decrease with some irregularities. We have observed that initially, the numbers of infections and deaths were inferior in comparison to the global situation but these increased alarmingly in the frst quarter of 2021 and continued for the next half of the year. It happened due to the lack of healthcare sustainability, infrm socio-economic conditions, defciency of technological advancement, and some troublesome issues caused by illiteracy. Te scarcity of basic knowledge about epidemiological diseases and their remedy was another origin of public sluggishness against the combat with COVID-19. Later on, time-worthy moves were taken, and region-wise lockdown and vaccination campaigns triggered substantial preventive outcomes. Also, compatible tactics for quarantines and isolations were pursued and applied throughout the country. Te ambience started to change in the fourth quarter of 2021, the number of infections and deaths remarkably declined, whereas the number of recoveries was highly signifcant which was moderate before. Tough in the middle of 2022 another raise of lethal infections were experienced in Bangladesh, it was released quickly, and nowadays, the pandemic ingredients are under control.

Data Availability
Te data used in this work can be found at the following link: https://github.com/mu2mahmud/Statistical-data-for-Covid -19-in-Bangladesh.

Consent
Informed consent was obtained from all individuals included in this study.