Effect of Penetration Electroacupuncture Combined with Intermediate Frequency Electrotherapy, Facial AcupointMassage, and Cervical Reduction on Facial Nerve Function and Curative Effect of Senile Refractory Facial Paralysis

Objective. ,is study aimed to explore the curative effects on senile refractory facial paralysis treated by penetration electroacupuncture combined with intermediate frequency electrotherapy, facial acupoint massage, and cervical reduction on facial nerve. Methods. 106 elderly patients with intractable facial paralysis that were retrospectively analyzed were all admitted from January 2019 to June 2020. ,e 106 patients were evenly divided into 2 groups according to the treatment method. ,e control group was treated with penetration electroacupuncture, while the observation group was treated with penetration electroacupuncture plus intermediate frequency electrotherapy+ facial acupoint massage + cervical reduction treatment. ,en, House–Brackmann (H-B) facial nerve function evaluation, RPA score, TCM syndrome score, disease remission rate, and incidence of adverse events were evaluated and compared between the two groups.Results. After 4 weeks of treatment, theH-B facial nerve function grading in the observation group was better than that in the control group (P< 0.05). And the disease remission rate after 1 week, 2 weeks, and 4 weeks of treatment was higher than that in the control group (P< 0.05). Meanwhile, the TCM syndrome score and RPA score after 2 weeks and 4 weeks of treatment were better than that in the control group (P< 0.05). Conclusion. For the elderly patients with refractory facial paralysis, the application of the combined treatment that penetration electroacupuncture +medium frequency electrotherapy+ facial acupoint massage + cervical adjustment can significantly improve the facial nerve function and reduce various diseases, and the effect of this combined treatment plan is more significant than that of penetration electroacupuncture treatment.


Introduction
Refractory facial paralysis refers to peripheral facial paralysis that has not improved for more than 2 months. e main clinical manifestations are incomplete eyelids, the angle of the mouth is tilted to one side, and there are no sequelae [1]. According to data statistics [2], 85% patients have a good prognosis after treatment, but a small number of patients are prone to hemifacial spasm, hemifacial interactions, and other sequelae due to improper treatment, delays, and physical factors. Although the disease is not life-threatening, it causes varying degrees of physical and psychological harm to patients, which will seriously affect the quality of life, social, and family to bring some of the burden. erefore, it is urgent to select an effective treatment plan for current clinical research to reduce the complications of sequelae [3,4].
In traditional Chinese medicine, refractory facial paralysis belongs to the category of "KouPi disease." It is caused by the patient's meridian being blocked and the disease invading, making the meridian qi and blood unsmooth.
ese pathological factors can cause muscle contraction dysfunction, and loss of nutrition in the facial meridians. In addition, the patients also suffer from syndrome of asthenia of qi and blood. erefore, the main principle of treatment is to help patients replenish Zheng qi and promote the circulation of qi and blood in the body [5]. Electroacupuncture can improve nerve excitability, regulate muscle tension, dredge local meridians, and promote muscle contraction and relaxation. In the clinical treatment of Chinese medicine, the unilateral treatment takes a long time, and the overall effect is not good, and therefore, the combined treatment with multimethods is recommended [6]. However, there are few clinical researches on the combination of penetration electroacupuncture + facial acupoint massage + intermediate frequency electrotherapy + cervical spine adjustment. Hence, our article investigates this combination treatment, analyzes the effects of various therapies on facial nerve function and disease remission rate, and provides ideas for comprehensive treatment of facial paralysis.

Data.
Inclusion criteria are as follows: (1) Patients meet the clinical diagnostic criteria for refractory facial paralysis in the "Guidelines for the Diagnosis and Treatment of Idiopathic Facial Paralysis in China" [7], with symptoms such as hemifacial spasm, drooping eyelids, and skewed corners of mouth. (2) Patients have a disease course of more than 2 months and are aged ≥60 years. (3) Patients only have one side of the face paralyzed.
Exclusion criteria are as follows: (1) Patients with serious diseases such as hematopoietic system and cardiovascular system. (2) Patients' facial nerves were damaged by intracranial tumors, brain fractures, cerebrovascular diseases, etc.
(3) Patients have a bleeding tendency or facial ulcers.
We selected 106 elderly patients with refractory facial paralysis for retrospective analysis, including 56 males and 50 females, aged 61 to 78 years, with an average age of 68.95 ± 5.32. e course of the 106 patients ranged from 3 to 14 months, with an average of 8.56 ± 3.35 months. And the weight range is 52∼75 kg, with an average o (61.48 ± 7.32 kg. e trial was conducted from January 2019 to June 2020, and the patienwerets was divided into a control group and an observation group, with 53 cases in each group. e baseline information of the two groups is balanced and comparable (P > 0.05) as shown in Table 1.
On the basis of the treatment plan of the control group, the observation group was combined with intermediate frequency electrotherapy + facial acupoint massage + cervical spine adjustment therapy. (3) Cervical spine reduction: the operator relaxes the skull base muscles, occipital muscles, and neck muscles by top-down flicking, rubbing, and finger pressure and then uses the cervical spine positioning and rotation method to recovery. e doctor stands behind the patient who sits on a chair, holds the patient's head, and puts thumbs on the occipital bone and index fingers on the mandibular plasma point. Let patient relax his head and lay it on the doctor's hands. And the operator rotates the head left and right to form a set of opposing movements. e operator holds the patient's pillow with one hand, hooks the mandible with the elbow, and presses protruding cervical spinous with the other thumb to promote the recovery of the misaligned joint. Both groups were treated for 6 consecutive days and rested for 1 day. One week is a course of treatment, and the treatment lasts for 4 weeks.

Observation Index.
(1) Facial nerve function evaluation by House-Brackmann (H-B) compared with the two groups: H-B index classification standard was according to that described by Xu [8]: Grade VI: the facial muscles are completely paralyzed, without movement. Grade V: the corners of the mouth move slightly, and the facial movements are almost imperceptible. Grade IV: the eyes that are not completely closed by force, a symmetrical face, and normal muscle tension; the corners of the mouth are still asymmetrical after correcting with maximum force. Grade III: facial symmetry with mild to moderate exercise, as well as obvious facial muscle weakness, correct the corners of the mouth with maximum strength. Grade II: the corners of the mouth are slightly asymmetrical and apply a little force. e eyes are completely closed, and muscle tone is normal. Grade I: the facial muscles move normally in each area. (2) Treatment effects evaluation of two groups by improved clinical simple scoring method (RPA points), TCM syndrome points. RPA score [9]: mainly evaluate the patient's cheeks, eyes closed, whistling, smiling, and frowning. Each item is worth 1 to 3 points, and the finally impression of quiet time adds 2 points, up to 20 points. e higher the evaluation score, the better the patient's recovery. TCM syndrome score [10]: mainly assess the patient's current flat nasolabial fold (0∼3 points), disappearance of forehead lines (0∼3 points), eyelid reduction (0∼3 points), and skewed corners of the mouth (0∼3 points). e more severe the symptoms, the higher the score. (3) Statistics of adverse events occurred during hospitalization of the two groups.

2.4.
Outcome Indicators. Disease remission rate � (N Recovery + N Significant effective + N Effective )/53 * 100%. Recovery: the patients with H-B facial nerve function I grade, whose left-and right-side muscles moved symmetrically, and facial muscle function returned to normal. Significant effect: the patients with H-B facial nerve function II grade, with the appearance of static symmetry and symptoms basically disappeared. Effective: the patients with H-B facial nerve function III level, in which most of the patients have normal, with most of the facial expression muscles recovered, and the appearances of minor contractures, synaptic movements, and facial spasms. Ineffective: the patients with H-B facial nerve function IV grade ∼ normal grade, who can only move their corner of the mouth slightly, and cannot completely close their eye fissures accompanied by facial asymmetry.

Statistical
Methods. All data were analyzed for significance by SPSS 25.0 software, and significance was assessed by t-test and ANOVA. Data were analyzed by χ2 test in enumeration and were presented as mean-± standard deviation (SD) in the estimation equation. P value < 0.05 was statistically significant. Graghpad Prism software was used to draw the histogram.

Comparison of H-B Facial Nerve Function Evaluation in the Two Groups.
e H-B facial nerve function levels were evaluated in the two groups. As shown in Table 2, there were significant differences between the observation group before and after treatment (z score: −6.327; P < 0.001), and significant differences were also present between the control group before and after treatment (z value: −3.951; P < 0.001). After treatment, the H-B facial nerve function classification of the observation group was significantly better than that of the control group (z value: −5.88; P < 0.001), shown in Table 2.

Comparison of the Outcome Indicators between the Two
Groups.
e RPA scores and TCM syndrome scores were measured and analyzed. As a result, there were statistical differences in RPA scores and TCM syndrome scores between the two groups (P < 0.05). However, in the beginning of the treatment, the RPA and TCM scores had no significant difference, that is, the baseline condition of the two groups was balanced and comparable. After treatment, the RPA scores in both groups were higher than that of before treatment (P < 0.05), while that of the TCM syndrome score was lower (P < 0.05). Notably, the RPA scores and TCM syndromes and RPA of the observation group were better than that of the control group after 2 weeks and 4 weeks of treatment (P < 0.05), shown in Table 3.

Comparison of Adverse Events in the Two Groups.
In the observation group, one case (1.89%) experienced discomfort. In the control group, one case (1.89%) had left needles, one Case (1.89%) had ecchymosis without pain, and one Case (1.89%) had discomfort. ere was no statistical difference between the two groups of adverse events (Figure 1; χ 2 value: 1.039; P value: 0.308).

Discussion
At present, the etiology and pathogenesis of refractory facial paralysis are still unclear with pharmacological therapy. Many scholars confirmed that facial paralysis related to optic nerve virus infection and the abnormal increase of IgG in the immune response is an important factor leading to facial paralysis [11]. e guidelines for the treatment of peripheral facial paralysis mainly include drugs, such as, glucocorticoids, antiviral therapy, neurotrophic and agents, surgical decompression, and neurorehabilitation [12]. However, refractory facial paralysis refers to symptoms such as drooping eyelids and crooked mouth angles after treatment. e guidelines have not yet clearly defined a unified standardized treatment plan. erefore, in clinical experience, Chinese medicine physiotherapies are often used to alleviate the symptoms [13]. According to the traditional Chinese medicine theory, refractory facial paralysis belongs to the categories of "skewed mouth and eyes" and "unusual mouth." According to historical books and records, the  Note: * P < 0.05, as compared to those before treatment; # P < 0.05 as compared to after 2 weeks of treatment.  disease is mostly caused by wind cold invading the meridians and empty meridians, causing loss of nourishment in the meridians, intrusion of the meridians, and obstruction of qi and blood [14]. "Lingshu·Jingjin" [15] records "Yangming is the lower eyelid, and the sun is the upper eyelid . . . e route of the meridians is from the supraclavicular fossa to the cheek. Heat will cause the muscles relax and the eyes cannot be opened. While, cold will cause the eyes to be unable to close." erefore, Chinese medicine believes that the location of facial paralysis lies in the meridians. Facial paralysis is caused by empty meridians, lack of righteousness, overwork, and wind-cold invasion of facial meridians. ese will cause facial meridian dysfunction, poor circulation of qi and blood, and muscle contraction disorders. Refractory facial paralysis is caused by the presence of evil facial qi, impaired righteousness and immunity, and insufficient muscle nutrition [16]. Penetrating electroacupuncture has the therapeutic effects of reconciling qi, blood, yin, and yang, strengthening the body and eliminating pathogens, invigorating the spleen and stomach, and regulating the supervisory channels. In this study, we selected Shenting, Dazhui, and Baihui to adjust the whole body's yang, then picked Zhongwan, Zusanli, and Sanyin to adjust the body's yin and balance the yin and yang, and finally choose Yifeng and Tianshu to invigorate qi and blood and to invigorate the spleen and stomach. Electroacupuncture at the above acupoints can promote the circulation of qi and blood, enhance the nutrition of qi and blood to the muscles, stimulate the facial nerve distribution area outside, promote the excitability of nerve cells, and improve the metabolism of nerve tissue [17,18]. Our treatment results showed that there are significant differences in comprehensive evaluation of the control group before and after treatment. It demonstrated that the penetrating electroacupuncture can dredge the facial meridians, reconcile qi and blood, cultivate vitality, and promote the improvement of disease symptoms [19]. e comparison of curative effect between the two groups found that the overall H-B facial nerve function in the observation group was better than that of the control group after 4 weeks of treatment, and the disease remission rate in each time period was higher than that of the control group. It is proved that on the basis of the penetration electroacupuncture, the combination treatment plan with intermediate frequency electrotherapy + facial acupoint massage + cervical cone adjustment can better restore nerve function and improve various symptoms. e possible reasons are as follows: (1) Facial acupoint massage can invigorate blood, dredge the meridians, and soothe the nerves. is helps us to increase muscle strength, prevent facial muscle atrophy, and stimulate motor nerves and muscle contraction, thereby, promoting the recovery of nerve function. Besides, massage is more comfortable than electric acupuncture, which could avoid facial nerve damage, and is more conducive to promoting facial nerve function [20]. (2) Cervical spine reduction can promote the normal physiological structure of the cervical spine and fundamentally relieve and eliminate the compression of spondyloarthritis on nerves and surrounding blood vessels. In addition, further maintaining the stability of the vertebral body with professional techniques can relieve muscle tension and spasm, promote the resolution of facial nerve inflammatory edema, ensure the blood supply of the facial nerve intracranial section, and restore the facial nerve function [21,22]. (3) Intermediate frequency electrotherapy can reduce inflammation, accelerate the absorption of edema, promote lymphatic reflux, and improve blood circulation. It strengthens the facial muscles, contracts the neurofacial muscles, and improves the nutritional status of the tissues [23,24]. e results showed that after treatment, the scores of TCM syndromes and RPA of the two groups of patients were improved compared with those before treatment. It indicated that penetration electroacupuncture can extently enhance the body's disease resistance, promote nearby lymphatic circulation, and restore muscle contractility. However, the recovery effect in a short time is not good. By contrary, the scores of TCM syndromes and RPA of the observation group were lower than those of the control group in each time period after treatment. It shows that penetration electroacupuncture combined with diversified traditional Chinese medicine treatments has Journal of Healthcare Engineering enhanced the therapeutic effect, such as stimulating the qi and blood, accelerating the repair of damaged nerves, increasing metabolism, promoting the transmission of nerve impulses, and restoring the nerve function. At present, although there is a large number of studies on refractory facial paralysis, there are few studies on refractory facial paralysis in the elderly. is is because the elderly have their own group characteristics, such as low immunity and slow recovery. erefore, our research on refractory facial paralysis of the elderly is very necessary. In addition, this study used more than three treatment methods to intervention for the first time and found that the combined treatment has better clinical efficacy. is combined intervention meets the clinical needs and is more beneficial to the hospitals.
is study provides new ideas for the clinical treatment of refractory t facial paralysis to the elderly and also provides objective basis for the theoretical study of the disease.
In summary, penetration electroacupuncture combined with intermediate frequency electrotherapy + facial acupoint massage + cervical spine adjustment plays a more comprehensive role in meridian differentiation, syndrome differentiation, and disease differentiation. is united treatment plan has the effects on increasing muscle strength, improving the local microenvironment of facial nerve. e treatment plan for patients with refractory facial paralysis is remarkable, and it is worthy of clinical promotion.

Data Availability
e labeled dataset used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest
e authors declare that there are no conflicts of interest.