Care of Maintenance Hemodialysis Patients through Intelligent Algorithm-Based Low-Dose Digital Subtraction Angiography

Objective. -e study aimed to explore the application value of artificial intelligence (AI)-based low-dose digital subtraction angiography (DSA) in the care of maintenance hemodialysis (MHD) patients.Methods. -e characteristics of DSA imaging were analyzed, and the refinement efficiency of the AI algorithm was discussed, expected to assist clinicians in the care and treatment of patients. 100 MHD patients who were in the hospital were selected as the research subjects. -ey were randomly divided into the conventional DSA group (conventional group) and the AI algorithm-based DSA group (AI-based DSA group). -e conventional group used conventional DSA images to guide the care of HM patients, and the AI-based DSA group used the AI algorithm to optimize DSA images. Results. It was found that the AI-based DSA group was better than the conventional DSA group in terms of image sharpness and shaded areas, and the image mean square error (MSE) loss value was smaller (P< 0.05). -e patients were followed up for 3 months. In the AI-based DAS group, the blood flow of the drainage vein (DV), the blood flow of the proximal vein (PA), and the blood flow of the brachial artery (BA) were greater than those of the conventional group (P< 0.05). During the 3-month follow-up period, in the conventional group, thrombosis occurred in 4 patients, low-flow AVF occurred in 5 patients, high-flowAVF occurred in 3 patients, and heart failure occurred in 5 patients. In the AI-based DSA group, thrombosis occurred in 2 patients, low-flow AVF occurred in 2 cases, high-flow AVF occurred in 1 case, and heart failure occurred in 3 cases. -ere were no other cardiac complications in both groups. Conclusion. DSA images optimized by the AI algorithm are suitable for clinical diagnosis and have practical application value.


Introduction
Chronic kidney disease (CKD) is a global concern [1]. Statistics reveal that the incidence of CKD in China is as high as 10.8%, and CKD is often diagnosed in the late stage of kidney disease. Hemodialysis (HD) is the main treatment method for CKD patients [2]. Blood vessels are considered to be the lifeline of HD patients, and the dialysis rate of longterm dialysis patients for HD within 1 year is 60%, and the medical cost is 2 to 3 times that of the ordinary patients [3].
erefore, effective countermeasures are required to reduce unnecessary medical expenses.
Digital subtraction angiography (DSA) is a medical imaging system based on X-rays used in clinical angiography [4]. DSA is necessary for the treatment of vascular diseases. It is not only widely used in the diagnosis of general vascular diseases but also used in clinical interventional therapy [5]. DSA images have high resolution and a wide range of gray levels, which can accurately present blood vessel. With the rapid development of medical image processing technologies, the DSA equipment has also been improved. Together, there are new requirements for the diagnosis of vascular diseases. DSA has problems such as the low quality of blood vessel subtraction images and high radiation dose, and the there is a lot of noise in the final DSA image. Except for the poor compliance of the patient and high-dose radiation, there exist artifacts [6]. When X-rays pass through the body, they are absorbed by the body tissue. Nevertheless, longterm exposure to X-ray will cause irreversible damage to human cells and DNA. In severe cases, it sometimes causes leukemia or cancer. Hence, reducing the radiation amount during DSA is a hot spot [7]. DSA image optimization is similar to traditional medical image enhancement, which mainly includes image enhancement and noise removal [8]. Image enhancement can filter background information according to the logarithmic correction method of X-ray attenuation rule [9]. e frame overlapping method can reduce random noise. In order to enhance the contrast of the background and blood vessels of DSA images, adaptive histograms are used to increase the gray level of local areas [10]. In areas with small gray-scale fluctuations, the contrast is poor, while in areas with large gray-scale fluctuations, there is too much artifact information. He et al. proposed that scale morphological enhancement can maintain most of the vascular structure, but it loses some vascular details and has low anti-noise strength [11]. Although postprocessing of DSA images heightens the doctor's diagnostic efficiency, the patient still suffers from high radiation doses due to the inability to clear artifacts [12]. e noise elimination of deep convolutional neural network (CNN) is realized by the network loss function. e entire network is a process of learning noise residuals, and the output results are significantly better than traditional algorithms [13,14]. Deep learning-based image processing requires multiple output tags corresponding to the input training data. Consequently, CNN can be applied to eliminate artifacts in DSA images, so as to reduce the radiation doses. Deep learning-based feature extraction extracts DSA vascular subtraction from a single frame to eliminate the dependence on the background frame and reduce the exposure time and radiation dose [15].
In this study, the back-projection filtering algorithm was used and optimized. Image refinement based on intelligent algorithms can improve nursing efficiency and reduce radiation dose and side effects. e peak signal-to-noise ratio (PSNR) was used to detect the noise reduction efficiency and study the vascular imaging characteristics in vascular dialysis.

Research Subjects.
In this study, 100 patients with MHD in the hospital from April 2019 to April 2021 were selected as research subjects. ey were randomly divided into the conventional DSA group (conventional group) and artificial intelligence-based DSA group (AI-based DSA group). e two groups of patients exercised for 20 minutes every day on non-dialysis days. Vascular conditions were detected with Doppler ultrasound. e curative effect indexed included the blood flow of the drainage vein (DV), proximal artery (PA) blood flow, carotid artery (CA) blood flow, DV diameter, and incidence of adverse events. e patients were selected as per the following inclusion criteria: (I) over 18 years old; (II) receiving MHD treatment for 3 months; and (III) good condition on dialysis.
Exclusion criteria were as follows: (I) the vascular retention tube was not removed; (II) arterial diameter >2 cm or exposure to the risk of rupture; (III) participating in other clinical trials at the same time; and (IV) with other blood diseases.
Withdrawal criteria were as follows: (I) requiring other surgeries and (II) accompanied by other diseases.
In this study, a total of 100 MHD patients were identified. is study has been approved by the Medical Ethics Committee of the hospital, and the family members of the patients included in the study had signed an informed consent form.

Dialysis Methods.
e HD device manufactured by Belem, Germany, was used. e dialysate was bicarbonate, and a polysulfone membrane dialysis device was used. During HD, to improve the anti-coagulation effect and reduce the side effects of bleeding, low-molecular-weight serine calcium was used as the main anti-coagulant for dialysis treatment.

DSA Examination.
During DSA, epidural anesthesia was used and the patient was in the supine position. Affected by the femoral artery, the lesions on both sides or one side were examined for anterograde or retrograde using the Seldinger technique. e human catheter was placed on the patient, and 2-13 mL of contrast agent was injected through a double-barrel high-pressure cylinder at a rate of 4-7 mL per second. en, the patient was scanned from the horizontal position of the renal artery to the sole of the foot.

DSA Imaging.
e low-dose DSA algorithm can reduce the radiation dose and obtain high-quality DSA vascular subtraction images without motion artifacts. e existing research on low-dose DSA algorithm is mainly to reduce radiation dose and remove artifacts. However, there are limitations. CNN has powerful non-linear mapping ability and can automatically extract global semantic features and local edge features of images. In recent years, deep learning has developed rapidly in the field of medical image processing. Based on deep learning, this study aimed to reduce the radiation dose of DSA vascular subtraction, remove the motion artifacts, and reduce the radiation dose received by patients while providing powerful assistance to interventional diagnosis and treatment. DSA imaging involves the injection of a contrast agent into the patient's blood vessel and subtraction of two images. Essentially, DSA refers to continuous X-ray images. Due to the different attenuation of human tissue to X-rays, corresponding gray-scale information is obtained for each frame of the image. e light intensity attenuates with the density and thickness of human tissue, which conforms to the Lambert-Beer law.
where A is the absorbance; T is the transmittance, namely, the ratio of the intensity of outgoing light (I) to the intensity of incident light (I 0 ); K is the molar absorption coefficient, and it is related to the absorbing material and the wavelength λ of the incident light; c is the concentration of the lightabsorbing substance, and the unit is mol/L; and b is the thickness of the absorbing layer. e mask image taken 2 Scientific Programming before the injection of the contrast agent can be expressed as follows: where ω is the attenuation coefficient of human tissue and a is the signal amplification factor during X-ray radiation.
After the contrast agent is injected, the contrast frame (live film) is expressed as follows: where ω 1 is the attenuation coefficient of the contrast agent in the blood vessel. For X-ray images, the gray level is 4096, black is 0, and white is 4096. One image is subtracted from the other to obtain the retained blood vessel information. e whole process is expressed as follows: (4) Figure 1 shows the flowchart. e vascular subtraction after logarithmic operation is not affected by bones and soft tissue. Figure 2 shows the entire DSA imaging process.

Medical Image Denoising.
e DSA images have many disadvantages. Especially in X-ray photography, information collection, transmission components, and information output are affected by different magnitudes of quantum noise. Artificial intelligence-based DSA imaging requires vascular subtraction labels with almost no noise and artifacts [16]. Reducing the influence of distance information on edge information can save high-frequency edge information. e blood vessel subtraction image including noise information is denoted as f � f, and the coordinates of any point P are (x, y). K is the neighborhood range of the bilateral filter width, expressed as follows: e pixel point after bilateral filtering operation is is the weight function of bilateral filtering, defined as follows.
where E(x, y) and E s (x, y) are the spatial proximity factor and the brightness similarity factor, respectively, and σ 2 1 and σ 2 K represent the Gaussian kernel variance that controls the similarity factor. Histogram equalization maps the gray level of pixels, stretches the gray value of the entire image range to an average shadow, and improves the contrast and saturation of the image. e gray level transformation function T(r) ensures that the order of the pixel gray levels remains unchanged after the transformation and maintains the consistency of the gray dynamic range before and after the transformation. r is the normalized gray level, and n is the total number of pixels. e histogram equalization function of the image is as follows: where k is the gray level of the image. e gray level transformation function T maps the r-level gray pixels in the image to H-level gray pixels. e voxels of angiographic bone are divided into 3 categories: blood vessels, bones, and soft tissue. e clinical data are divided by artificial thresholds, and small areas of shadows are considered residual artifacts. e blood vessel label is obtained by filtering motion artifacts and background noise. Numerical segmentation and connectivity analysis are performed in the background frame. Soft tissue labeling is performed by angiographic segmentation.

Artificial Intelligence-Based
e CNN-based angiography can effectively solve the artifacts without relying on the background frame. It eliminates the necessity of background frame collection and reduces the radiation dose. e process of obtaining classification labels is shown in Figure 3.

DSA Image Quality
Evaluation. Image quality evaluation (IQE) was used to scientifically evaluate the quality of DSA images. Image quality evaluation methods include subjective evaluation and objective evaluation. e subjective evaluation requires multiple experiments, and the imaging effects are determined based on the subjective factors of experts. Objective evaluation quantifies the quality of vascular subtraction based on mathematical models and scientifically determines the quality of overall and partial medical images. For example, mean square error (MSE) is used to measure the difference between estimators. e objective evaluation method is based on the absolute error between pixels. Due to the specificity of DSA images, blood vessels should be clearly displayed. MSE is expressed as follows: PSNR � 10 log 10 where M × N represents the size of CT and u and f are the original image and the noise-removed image, respectively. A higher PSNR value indicates a smaller MAE and better image noise reduction effects. Structural similarity difference (SSIM) is expressed as follows: where u and f represent the original image and the noiseremoved image, X and Y represent the original image and the noise, N represents the average value of the gray value of the pixel, that is, the dispersion of the gray value of the pixel of the image, and C1 and C2, which are the covariances of Scientific Programming image blocks x and y, are small constants to guarantee that the denominator is not zero. A larger SSIM value indicates that the noise-removed image and the original image are more similar.

Network Training and
Testing. e DSA artifact removal network has an end-to-end structure, and the parameters of the training process are set as follows. e learning rate is 0.0001, the amount of input data is 8, and the number of network iterations is 100. e complexity of the online extended dataset and the network model determines the training time of the model, which is about 12 hours.

Statistics.
e data were processed by SPSS21.0. e result of DSA was the gold standard, that is, the data were consistent with the normal distribution, so the mean-± standard deviation (x(− ) ± s) was used. P < 0.05 was the threshold for significance.

Experiment Results of Network Model.
Evaluation of the image processed by the AI algorithm included objective quantitative evaluation and subjective qualitative analysis. e DSA image with artifacts was used as the network input data. An objective quality evaluation was carried out on the non-artifact test set. e subjective evaluation compared the images optimized by the conventional method and AI algorithm (Figures 4-6). e subjective evaluation results showed that the motion artifacts were eliminated, and the image had high contrast, with blood vessel details well preserved. AI algorithm can remove artifacts and save blood vessel images. e AI algorithm based on deep learning was efficient and reduced the radiation dose.
In order to objectively evaluate the results of different network models, DSA image datasets of the brain and feet were tested. Figure 7 shows the average PSNR and SSIM of the lower limbs and cerebral vessels according to different methods. e results showed that DSA images optimized by the AI algorithm achieved good results in terms of PSNR and SSIM.

MSE Loss Values.
is section compared the scatter points of the MSE loss value of the conventional method and the AI algorithm. e red dots represented the conventional method, and the black dots represented the AI algorithm. It was noted from Figure 8 that in the initial stage of AI training, it converged steadily and quickly, and the training loss value decreased and converged equally. is suggested that AI algorithm enabled a larger receptive field, and the dilated convolution also prevented information loss caused by increased pooling.

DV Blood Flow.
e changes of DV blood flow within 3 months of follow-up were recorded, as shown in Figure 9. e interaction effect of DV blood flow was statistically different (P < 0.001), indicating that two DSA image processing methods had different effects on DV blood flow.

PA Blood Flow between the Two Groups.
It was found that the difference between different time points was statistically significant (P < 0.001), indicating that the patient's PA blood flow changed with time. e PA blood flow at 1, 2, and Step 1 Step 2 Step 3  3 months of follow-up was statistically different from that before the intervention (P < 0.05), as shown in Figure 10.

BA Blood Flow between the Two Groups.
It was found that the time had no statistically significant effect on BA blood flow (P � 0.176), indicating that there was no interaction between time and grouping; BA blood flow at 3 months after the intervention was statistically different from that at 2 months after the intervention (P � 0.013), as shown in Figure 11.
3.6. DV Diameters. It was found that the DV diameter at 2 months after the intervention was statistically different from that before the intervention (P < 0.05), and DV diameter at 3 months after the intervention was statistically different from that at 1 month after the intervention (P < 0.001); the difference was 0.45, as shown in Figure 12.    Scientific Programming occurred in 2 cases, high-flow AVF occurred in 1 case, and heart failure occurred in 3 cases, as shown in Figure 13. ere were no other cardiac complications in both groups.

Discussion
With the aging of the population, the incidence of CKD has shown a rapid increase [17]. End-stage kidney disease requires kidney replacement therapy, mainly HD, peritoneal dialysis, and kidney transplantation. HD is an effective kidney replacement therapy. It executes the renal excretion function to eliminate blood metabolic wastes and electrolyte barriers. To maintain acid-base balance, different patients need distinct treatment plans. DSA can well observe the physiological conditions of the patient's blood vessels [18]. ere was no statistically significant difference between the two groups at the beginning, while in January, DV blood flow was 971 mL/min in the conventional group and 1079 mL/min in the AI-based DSA group; in February, the DV blood flow in the conventional group was 977 mL/min, and that of AI-based DSA group was 1196 mL/min; in March, DV blood flow was 1001 mL/min in the conventional group and 1592 mL/min in the AI-based DSA group. ere was significant difference between the two groups. ere was no statistically significant difference between the two groups at the beginning, while in January, the PA blood flow was 713 mL/min in the conventional group and 781 mL/min in the AI-based DSA group; in February, PA blood flow was 689 mL/min in the conventional group and 792 mL/min in the AI-based DSA group; in March, PA blood flow was 684 mL/min in the conventional group and 799 mL/min in the AI-based DSA group, with statistical difference between the two groups (P < 0.05). During the 3-month follow-up period, in the conventional group, thrombosis occurred in 4 patients, low-flow AVF occurred in 5 patients, high-flow AVF occurred in 3 patients, and heart failure occurred in 5 patients. In the AI-based DSA group, thrombosis occurred in 2 patients, low-flow AVF occurred in 2 cases, high-flow AVF occurred in 1 case, and heart failure occurred in 3 cases.
ere were no other cardiac complications in both groups. However, DSA requires high-dose X-ray radiation, which threatens the health of patients. DSA essentially refers to multiple frames of X-ray images, and DSA images contain many artifacts that affect doctors' diagnosis. erefore, DSA must be performed again, which increases the radiation dose and reduces the doctor's diagnostic efficiency. How to obtain high-quality vascular images and reduce the radiation dose has become a hot spot [19,20]. e traditional method to remove DSA artifacts reduces vascular contrast. As a result, partial blood vessels are unclear. Artificial intelligence has found broad applications in the field of medical image processing and has a strong automatic learning function. In this study, in order to reduce the radiation doses during DSA and remove artifacts, the DSA images were optimized by an AI algorithm.

Conclusion
In this study, an AI algorithm was used to optimize DSA images, and its optimization effects were compared with the conventional method. It was found that the AI algorithm demonstrated better capabilities in removing the image artifacts, with low distortion rate and high resolution. e   blood vessels were clearly displayed; in a word, it has guiding significance for the diagnosis and treatment of diseases.

Data Availability
e data used to support the findings of this study are available from the corresponding author upon request.

Conflicts of Interest
e author declares that there are no conflicts of interest.